Dr Dean Sculley
School of Biomedical Sciences and Pharmacy (Human Physiology)
- Phone:(02) 4349 4596
Dr Dean Sculley graduated from the University of Northampton in 1998 with an honours degree in Human Biology. He received his MSc in Exercise Physiology from Manchester Metropolitan University in 2000 and a PhD from the University of Leicester in 2004, under the supervision of Professor Simon Langley-Evans. This was followed by a British Heart Foundation-funded Post-Doctoral Research Fellowship at the University of Nottingham, investigating the effects of maternal nutritional modulation and its effects on Foetal and Developmental Programming in offspring. He held a lectureship at the University of Northampton until 2007, and has held a lectureship in Human Physiology at the University of Newcastle since 2008.
Research expertise is centred around Oxidative Stress and Inflammation in relation to disease. His PhD research investigated the effects of salivary antioxidant capacity and its effect on Periodontal Disease status. During this research, he was the first to measure oxidative stress in saliva using Protein Carbonyls as a biomarker and quantifying salivary antioxidants by flow rate rather than static measurement. Key findings also include salivary antioxidant capacity and profile being independent to dietary intake and plasma profile, and disease severity being inversely related to salivary antioxidant capacity. During his Fellowship, Dr Sculley investigated the effects of maternal undernutrition on the antioxidant capacity in offspring. More specifically, activity of Superoxide Dismutase, Catalase and Glutathione were studied in relation to oxidative stress in tissues such as brain, heart, lung, kidney, liver and eye. Major effects found include significant programming effects on liver and kidney tissues, leading to a reduction in antioxidant capacity and an increase in free radical-mediated tissue damage. Effects were especially apparent in kidney tissue, with significant premature loss of nephrons and accelerated kidney dysfunction.
Recent research includes the effects of Omega-3 fatty acids and the inflammatory cascade in Periodontal Disease and Systemic Hypoxia, the inflammatory response and muscle function. Current research focuses on Juvenile Idiopathic Arthritis and Diabetes and involves the use of smart devices and wireless technology in the promotion, adherence and monitoring of physical exertion in the management of disease. In addition, current research is also determining the effect of maternal nutrition and lifestyle factors affecting foetal growth and development in utero and the implications these have on disease in the offspring, specifically Type 2 Diabetes.
Dr Dean Sculley has been teaching all aspects of Human Physiology to undergraduates since 2006. He is Course Co-ordinator for HUBS1401 and HUBS1417 and teaches HUBS1406 and Immunity,Microbiology and Genetics modules in HUBS1416. In addition, he also delivers lectures and lab sessions for HUBS2207 Human Metabolism and Nutritional Biochemistry and writes and delivers the Human Biology preparatory course – PREP096 – to new students prior to Semester 1. He is consistently rated amongst the highest performers in both course design and teaching throughout the University.
Research collaborations include:
The investigation of Periodontal Disease during the fitment of orthodontic devices with Associate Professor Jane Taylor, School of Health Sciences, Faculty of Health and Medicine.
The effects of sex hormones in physical performance in female athletes with Dr Xanna Janse De Jonge, School of Environmental and Life Sciences, Faculty of Science.
The use of smart technology in the management and treatment of Juvenile Idiopathic Arthritis and Diabetes with Dr Andrea Coda, School of Health Sciences, Faculty of Health and Medicine.
- Doctor of Philosophy, University of Leicester - UK
- Bachelor of Science, The University of Northampton - UK
- Master of Science, Manchester Metropolitan University - UK
- Human Physiology
- Oxidative Stress
- Periodontal Disease
- Developmental Programming
- Interuterine Growth Restriction
- English (Fluent)
Fields of Research
|060699||Physiology not elsewhere classified||40|
|111199||Nutrition and Dietetics not elsewhere classified||40|
|111499||Paediatrics and Reproductive Medicine not elsewhere classified||20|
|Title||Organisation / Department|
|Casual Lecturer||University of Newcastle
Centre for English Language and Foundation Studies
|Senior Lecturer||University of Newcastle
School of Biomedical Sciences and Pharmacy
|Dates||Title||Organisation / Department|
|1/01/2008 -||Lecturer||University of Newcastle
Faculty of Health and Medicine
For publications that are currently unpublished or in-press, details are shown in italics.
Chapter (1 outputs)
Dascombe BJ, Elsworthy N, Scott B, Sculley DV, Reaburn PRJ, 'Physiological changes affecting performance of masters athletes', Nutrition and performance in masters athletes, CRC PRess, Boca Raton, FL 17-45 (2015) [B1]
Journal article (27 outputs)
Coda A, Sculley D, Santos D, Girones X, Acharya S, 'Exploring the Effectiveness of Smart Technologies in the Management of Type 2 Diabetes Mellitus', Journal of Diabetes Science and Technology, 1 (2018) [C1]
Stevens CJ, Kittel A, Sculley DV, Callister R, Taylor L, Dascombe BJ, 'Running performance in the heat is improved by similar magnitude with pre-exercise cold-water immersion and mid-exercise facial water spray', JOURNAL OF SPORTS SCIENCES, 35 798-805 (2017) [C1]
Scott BR, Slattery KM, Sculley DV, Lockhart C, Dascombe BJ, 'ACUTE PHYSIOLOGICAL RESPONSES TO MODERATE-LOAD RESISTANCE EXERCISE IN HYPOXIA', JOURNAL OF STRENGTH AND CONDITIONING RESEARCH, 31 1973-1981 (2017) [C1]
Scott BR, Slattery KM, Sculley DV, Smith SM, Peiffer JJ, Dascombe BJ, 'Acute physiological and perceptual responses to high-load resistance exercise in hypoxia', Clinical Physiology and Functional Imaging, (2017)
© Scandinavian Society of Clinical Physiology and Nuclear Medicine. This study assessed whether hypoxia during high-load resistance exercise could enhance the acute physiological ... [more]
© Scandinavian Society of Clinical Physiology and Nuclear Medicine. This study assessed whether hypoxia during high-load resistance exercise could enhance the acute physiological responses related to muscular development. Twelve trained men performed exercise in three conditions: normoxia (fraction of inspired oxygen [F I O 2 ] = 21%), moderate-level hypoxia (F I O 2 = 16%) and high-level hypoxia (F I O 2 = 13%). Exercise comprised high-load squats and deadlifts (5 × 5 using 80% of 1-repetition maximum with 180-s rest). Muscle oxygenation and activation were monitored during exercise. Metabolic stress was estimated via capillary blood sampling. Perceived fatigue and soreness were also quantified following exercise. While the hypoxic conditions appeared to affect muscle oxygenation, significant differences between conditions were only noted for maximal deoxyhaemoglobin in the deadlift (P = 0·009). Blood lactate concentration increased from 1·1 to 1·2 mmol l -1 at baseline to 9·5-9·8 mmol l -1 after squats and 10·4-10·5 mmol l -1 after deadlifts (P=0·001), although there were no between-condition differences. Perceived fatigue and muscle soreness were significantly elevated immediately and at 24 h following exercise, respectively, by similar magnitudes in all conditions (P=0·001). Muscle activation did not differ between conditions. While metabolic stress is thought to moderate muscle activation and subsequent muscular development during hypoxic resistance training, it is not augmented during traditional high-load exercise. This may be explained by the low number of repetitions performed and the long interset rest periods employed during this training. These findings suggest that high-load resistance training might not benefit from additional hypoxia as has been shown for low- and moderate-load training.
Stevens CJ, Bennett KJM, Sculley DV, Callister R, Taylor L, Dascombe BJ, 'A Comparison of Mixed-Method Cooling Interventions on Preloaded Running Performance in the Heat', Journal of Strength and Conditioning Research, 31 620-629 (2017) [C1]
© 2016 National Strength and Conditioning Association. Stevens, CJ, Bennett, KJM, Sculley, DV, Callister, R, Taylor, L, and Dascombe, BJ. A comparison of mixed-method cooling inte... [more]
© 2016 National Strength and Conditioning Association. Stevens, CJ, Bennett, KJM, Sculley, DV, Callister, R, Taylor, L, and Dascombe, BJ. A comparison of mixed-method cooling interventions on preloaded running performance in the heat. J Strength Cond Res 31(3): 620-629, 2017 - The purpose of this investigation was to assess the effect of combining practical methods to cool the body on endurance running performance and physiology in the heat. Eleven trained male runners completed 4 randomized, preloaded running time trials (20 minutes at 70% Vo 2 max and a 3 km time trial) on a nonmotorized treadmill in the heat (33° C). Trials consisted of precooling by combined cold-water immersion and ice slurry ingestion (PRE), midcooling by combined facial water spray and menthol mouth rinse (MID), a combination of all methods (ALL), and control (CON). Performance time was significantly faster in MID (13.7 ± 1.2 minutes; p < 0.01) and ALL (13.7 ± 1.4 minutes; p = 0.04) but not PRE (13.9 ± 1.4 minutes; p = 0.24) when compared with CON (14.2 ± 1.2 minutes). Precooling significantly reduced rectal temperature (initially by 0.5 ± 0.2° C), mean skin temperature, heart rate and sweat rate, and increased iEMG activity, whereas midcooling significantly increased expired air volume and respiratory exchange ratio compared with control. Significant decreases in forehead temperature, thermal sensation, and postexercise blood prolactin concentration were observe d in all conditions compared with control. Performance was improved with midcooling, whereas precooling had little or no influence. Midcooling may have improved performance through an attenuated inhibitory psychophysiological and endocrine response to the heat.
Coda A, Sculley D, Santos D, Girones X, Brosseau L, Smith DR, et al., 'Harnessing interactive technologies to improve health outcomes in juvenile idiopathic arthritis', Pediatric Rheumatology, 15 40-45 (2017) [C1]
Scott BR, Slattery KM, Sculley DV, Dascombe BJ, 'Hypoxia during resistance exercise does not affect physical performance, perceptual responses, or neuromuscular recovery.', Journal of strength and conditioning research, (2017)
Stevens CJ, Thoseby B, Sculley DV, Callister R, Taylor L, Dascombe BJ, 'Running performance and thermal sensation in the heat are improved with menthol mouth rinse but not ice slurry ingestion', Scandinavian Journal of Medicine and Science in Sports, 26 1209-1216 (2016) [C1]
ï¿½ 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd The purpose of this study was to compare the effects of a cooling strategy designed to predominately... [more]
ï¿½ 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd The purpose of this study was to compare the effects of a cooling strategy designed to predominately lower thermal state with a strategy designed to lower thermal sensation on endurance running performance and physiology in the heat. Eleven moderately trained male runners completed familiarization and three randomized, crossover 5-km running time trials on a non-motorized treadmill in hot conditions (33 ï¿½C). The trials included ice slurry ingestion before exercise (ICE), menthol mouth rinse during exercise (MEN), and no intervention (CON). Running performance was significantly improved with MEN (25.3 ï¿½ 3.5 min; P = 0.01), but not ICE (26.3 ï¿½ 3.2 min; P = 0.45) when compared with CON (26.0 ï¿½ 3.4 min). Rectal temperature was significantly decreased with ICE (by 0.3 ï¿½ 0.2 ï¿½C; P < 0.01), which persisted for 2 km of the run and MEN significantly decreased perceived thermal sensation (between 4 and 5 km) and ventilation (between 1 and 2 km) during the time trial. End-exercise blood prolactin concentration was elevated with MEN compared with CON (by 25.1 ï¿½ 24.4 ng/mL; P = 0.02). The data demonstrate that a change in the perception of thermal sensation during exercise from menthol mouth rinse was associated with improved endurance running performance in the heat. Ice slurry ingestion reduced core temperature but did not decrease thermal sensation during exercise or improve running performance.
Stevens CJ, Hacene J, Wellham B, Sculley DV, Callister R, Taylor L, Dascombe BJ, 'The validity of endurance running performance on the Curve 3<sup>TM</sup> non-motorised treadmill', Journal of Sports Sciences, 33 1141-1148 (2015) [C1]
© 2014, © 2014 Taylor & Francis. Abstract: This study aimed to test the validity of a non-motorised treadmill (NMT) for the measurement of self-paced overground endurance ru... [more]
© 2014, © 2014 Taylor & Francis. Abstract: This study aimed to test the validity of a non-motorised treadmill (NMT) for the measurement of self-paced overground endurance running performance. Ten male runners performed randomised 5-km running time trials on a NMT and an outdoor athletics track. A range of physiological and perceptual responses was measured, and foot strike was classified subjectively. Performance time was strongly correlated (r¿=¿0.82, ICC¿=¿0.86) between running modes, despite running time being significantly longer on the NMT (1264¿±¿124¿s vs. 1536¿±¿130¿s for overground and NMT, respectively; P¿ < ¿0.001). End blood lactate concentration and rating of perceived exertion were significantly higher on the NMT compared to overground. Integrated electromyography was significantly lower on the NMT for three muscles (P¿ < ¿0.05), and mean stride rate was also significantly lower on the NMT (P¿=¿0.04). Cardiorespiratory responses of heart rate, oxygen uptake and expired air volume demonstrated strong correlations (r¿=¿0.68¿0.96, ICC¿=¿0.75¿0.97) and no statistical differences (P¿ > ¿0.05). Runners were consistently slower on the NMT, and as such it should not be used to measure performance over a specific distance. However, the strong correlations suggest that superior overground performance was reflected in relative terms on the NMT, and therefore, it is a valid tool for the assessment of endurance running performance in the laboratory.
Scott BR, Slattery KM, Sculley DV, Hodson JA, Dascombe BJ, 'Physical performance during high-intensity resistance exercise in normoxic and hypoxic conditions', Journal of Strength and Conditioning Research, 29 807-815 (2015) [C1]
© 2015 National Strength and Conditioning Association. This study aimed to determine whether different levels of hypoxia affect physical performance during high-intensity resistan... [more]
© 2015 National Strength and Conditioning Association. This study aimed to determine whether different levels of hypoxia affect physical performance during high-intensity resistance exercise or subsequent cardiovascular and perceptual responses. Twelve resistance-trained young men (age, 25.3 ± 4.3 years; height, 179.0 ± 4.5 cm; body mass, 83.4 ± 9.1 kg) were tested for 1 repetition maximum (1RM) in the back squat and deadlift. Following this, participants completed 3 separate randomized trials of 5 × 5 repetitions at 80% 1RM, with 3 minutes rest between sets, in normoxia (NORM; fraction of inspired oxygen [F I O 2 ] 0.21), moderate-level hypoxia (F I O 2 0.16), or high-level hypoxia (F I O 2 0.13) by a portable hypoxic unit. Peak and mean force and power variables were monitored during exercise. Arterial oxygen saturation (SpO 2), heart rate (HR), and rating of perceived exertion (RPE) were assessed immediately following each set. No differences in force or power variables were evident between conditions. Similar trends were evident in these variables across each set and across the exercise session in each condition. SpO 2 was lower in hypoxic conditions than in NORM, whereas HR was higher following sets performed in hypoxia. There were no differences between conditions in RPE. These results indicate that a hypoxic stimulus during high-intensity resistance exercise does not alter physical performance during repetitions and sets or affect how strenuous exercise is perceived to be. This novel training strategy can be used without adversely affecting the physical training dose experienced and may provide benefits over the equivalent training in NORM.
Stevens CJ, Hacene J, Sculley DV, Taylor L, Callister R, Dascombe B, 'The Reliability of Running Performance in a 5 km Time Trial on a Non-motorized Treadmill', International Journal of Sports Medicine, 36 705-709 (2015) [C1]
The purpose of the study was to establish the reliability of performance and physiological responses during a self-paced 5 km running time trial on a non-motorized treadmill. 17 m... [more]
The purpose of the study was to establish the reliability of performance and physiological responses during a self-paced 5 km running time trial on a non-motorized treadmill. 17 male runners (age: 32±13 years, height: 177±7 cm, body mass: 71±9 kg, sum of 7 skinfolds: 55±21 mm) performed familiarization then 2 separate maximal 5 km running time trials on a non-motorized treadmill. Physiological responses measured included heart rate, oxygen uptake, expired air volume, blood lactate concentration, tissue saturation index and integrated electromyography. Running time (1 522±163 s vs. 1 519±162 s for trials 1 and 2, respectively) demonstrated a low CV of 1.2% and high ICC of 0.99. All physiological variables had CVs of less than 4% and ICCs of > 0.92, with the exception of blood lactate concentration (7.0±2 mmol·L -1 vs. 6.5±1.5 mmol·L -1 for trials 1 and 2, respectively; CV: 12%, ICC: 0.83) and the electromyography measures (CV: 8-27%, ICC: 0.71-0.91). The data demonstrate that performance time in a 5 km running time trial on a non-motorized treadmill is a highly reliable test. Most physiological responses measured across the 5 km run also demonstrated good reliability.
Sculley DV, 'Periodontal disease: Modulation of the inflammatory cascade by dietary n-3 polyunsaturated fatty acids', Journal of Periodontal Research, 49 277-281 (2014) [C1]
Periodontal disease, including gingivitis and periodontitis, is caused by the interaction between pathogenic bacteria and the host immune system. The ensuing oxidative stress and ... [more]
Periodontal disease, including gingivitis and periodontitis, is caused by the interaction between pathogenic bacteria and the host immune system. The ensuing oxidative stress and inflammatory cascade result in the destruction of gingival tissue, alveolar bone and periodontal ligament. This article reviews the underlying mechanisms and host-bacteria interactions responsible for periodontal disease and evidence that nutritional supplementation with fish oil may provide a protective effect. Historical investigations of diet and disease have highlighted an inverse relationship between ingestion of fish oil, which is high in n-3 polyunsaturated fatty acids, and the incidence of typical inflammatory diseases such as arthritis and coronary heart disease. Ingestion of n-3 polyunsaturated fatty acids, such as docosahexaenoic acid and eicosapentaenoic acid, results in their incorporation into membrane phospholipids, which can alter eicosanoid production after stimulation during the immune response. These eicosanoids promote a reduction in chronic inflammation, which has led to the proposal that fish oil is a possible modulator of inflammation and may reduce the severity of periodontal diseases. Tentative animal and human studies have provided an indication of this effect. Further human investigation is needed to establish the protective effects of fish oil in relation to periodontal disease. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Scott BR, Slattery KM, Dascombe BJ, Sculley DV, 'Hypoxia and Resistance Exercise: A Comparison of Localized and Systemic Methods', Sports Medicine, (2014) [C1]
It is generally believed that optimal hypertrophic and strength gains are induced through moderate- or high-intensity resistance training, equivalent to at least 60 % of an indivi... [more]
It is generally believed that optimal hypertrophic and strength gains are induced through moderate- or high-intensity resistance training, equivalent to at least 60 % of an individual's 1-repetition maximum (1RM). However, recent evidence suggests that similar adaptations are facilitated when low-intensity resistance exercise (~20-50 % 1RM) is combined with blood flow restriction (BFR) to the working muscles. Although the mechanisms underpinning these responses are not yet firmly established, it appears that localized hypoxia created by BFR may provide an anabolic stimulus by enhancing the metabolic and endocrine response, and increase cellular swelling and signalling function following resistance exercise. Moreover, BFR has also been demonstrated to increase type II muscle fibre recruitment during exercise. However, inappropriate implementation of BFR can result in detrimental effects, including petechial haemorrhage and dizziness. Furthermore, as BFR is limited to the limbs, the muscles of the trunk are unable to be trained under localized hypoxia. More recently, the use of systemic hypoxia via hypoxic chambers and devices has been investigated as a novel way to stimulate similar physiological responses to resistance training as BFR techniques. While little evidence is available, reports indicate that beneficial adaptations, similar to those induced by BFR, are possible using these methods. The use of systemic hypoxia allows large groups to train concurrently within a hypoxic chamber using multi-joint exercises. However, further scientific research is required to fully understand the mechanisms that cause augmented muscular changes during resistance exercise with a localized or systemic hypoxic stimulus. © 2014 Springer International Publishing Switzerland.
Scott BR, Dascombe BJ, Delaney JA, Elsworthy N, Lockie RG, Sculley DV, Slattery KM, 'The Validity and Reliability of a Customized Rigid Supportive Harness During Smith Machine Back Squat Exercise', JOURNAL OF STRENGTH AND CONDITIONING RESEARCH, 28 636-642 (2014) [C1]
Scott BR, Slattery KM, Sculley DV, Lockie RG, Dascombe BJ, 'Reliability of telemetric electromyography and near-infrared spectroscopy during high-intensity resistance exercise', Journal of Electromyography and Kinesiology, 24 722-730 (2014) [C1]
This study quantified the inter- and intra-test reliability of telemetric surface electromyography (EMG) and near infrared spectroscopy (NIRS) during resistance exercise. Twelve w... [more]
This study quantified the inter- and intra-test reliability of telemetric surface electromyography (EMG) and near infrared spectroscopy (NIRS) during resistance exercise. Twelve well-trained young men performed high-intensity back squat exercise (12 sets at 70-90% 1-repetition maximum) on two occasions, during which EMG and NIRS continuously monitored muscle activation and oxygenation of the thigh muscles. Intra-test reliability for EMG and NIRS variables was generally higher than inter-test reliability. EMG median frequency variables were generally more reliable than amplitude-based variables. The reliability of EMG measures was not related to the intensity or number of repetitions performed during the set. No notable differences were evident in the reliability of EMG between different agonist muscles. NIRS-derived measures of oxyhaemoglobin, deoxyhaemoglobin and tissue saturation index were generally more reliable during single-repetition sets than multiple-repetition sets at the same intensity. Tissue saturation index was the most reliable NIRS variable. Although the reliability of the EMG and NIRS measures varied across the exercise protocol, the precise causes of this variability are not yet understood. However, it is likely that biological variation during multi-joint isotonic resistance exercise may account for some of the variation in the observed results. © 2014 Elsevier Ltd.
Stevens CJ, Dascombe B, Boyko A, Sculley D, Callister R, 'Ice slurry ingestion during cycling improves Olympic distance triathlon performance in the heat', Journal of Sports Sciences, 31 1271-1279 (2013) [C1]
This study investigated the effect of ice slurry ingestion during a triathlon on intragastric temperature and 10 km running performance in the heat. Nine well-trained male triathl... [more]
This study investigated the effect of ice slurry ingestion during a triathlon on intragastric temperature and 10 km running performance in the heat. Nine well-trained male triathletes performed two randomised trials of a simulated Olympic distance triathlon in hot conditions (32-34°C). Exercise intensity during the swim (1500 m) and cycle (1 hr) legs was standardised, and the 10 km run leg was a self-paced time trial. During the cycle leg, either 10 g · kgBM -1 of ice slurry ( < 1°C) or room temperature fluid (32-34°C) was ingested. In the run leg of the ice slurry trial, performance time (43.4 ± 3.7 vs. 44.6 ± 4.0 min; P = 0.03), intragastric temperature (at 1.5 km; 35.5 ± 1.2 vs. 37.5 ± 0.4°C; P = 0.002) and perceived thermal stress (at 5 km; 73 ± 9 vs. 80 ± 7 mm; P = 0.04) were significantly lower. Oxygen consumption was significantly higher in the ice trial between 9.5-10 km (52.4 ± 3.4 vs. 47.8 ± 5.4 mL · kg -1 · min -1 ; P = 0.04). The results suggest ice slurry ingestion was an effective ergogenic aid for triathlon running performance in the heat. The attenuation of intragastric temperature and perceived thermal stress were likely contributors to the self-selection of a higher running intensity and improved performance time. © 2013 Taylor & Francis.
Mallinson JE, Sculley DV, Craigon J, Plant R, Langley-Evans SC, Brameld JM, 'Fetal exposure to a maternal low-protein diet during mid-gestation results in muscle-specific effects on fibre type composition in young rats', BRITISH JOURNAL OF NUTRITION, 98 292-299 (2007) [C1]
Erhuma A, Salter AM, Sculley DV, Langley-Evans SC, Bennett AJ, 'Prenatal exposure to a low-protein diet programs disordered regulation of lipid metabolism in the aging rat', AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 292 E1702-E1714 (2007) [C1]
Langley-Evans SC, Bellinger L, Sculley D, Langley-Evans A, McMullen S, 'Manipulation of the maternal diet in rat pregnancy. Different approaches to the demonstration of the programming principle', EARLY LIFE ORIGINS OF HEALTH AND DISEASE, 573 87-102 (2006)
Bellinger L, Sculley DV, Langley-Evans SC, 'Exposure to undernutrition in fetal life determines fat distribution, locomotor activity and food intake in ageing rats', INTERNATIONAL JOURNAL OF OBESITY, 30 729-738 (2006) [C1]
Langley-Evans SC, Sculley DV, 'The association between birthweight and longevity in the rat is complex and modulated by maternal protein intake during fetal life', FEBS LETTERS, 580 4150-4153 (2006) [C1]
Erhuma AM, Sculley D, Plant R, Salter AM, Langley-Evans SC, Bennett AJ, 'Exposure to a maternal low-protein diet in pregnancy programmes altered expression of sterol regulatory element-binding protein-1c and carbohydrate responsive element-binding protein in the offspring', PROCEEDINGS OF THE NUTRITION SOCIETY, 64 81A-81A (2005)
|2005||Sculley DV, Langley-Evans SC, 'Age-related loss of renal function is driven by programmed oxidative processes in the rat', PROCEEDINGS OF THE NUTRITION SOCIETY, 64 83A-83A (2005)|
Langley-Evans SC, Sculley DV, 'Programming of hepatic antioxidant capacity and oxidative injury in the ageing rat', MECHANISMS OF AGEING AND DEVELOPMENT, 126 804-812 (2005) [C1]
Sculley DV, Langley-Evans SC, 'Periodontal disease is associated with lower antioxidant capacity in whole saliva and evidence of increased protein oxidation', CLINICAL SCIENCE, 105 167-172 (2003) [C1]
Sculley DV, Langley-Evans SC, 'Salivary antioxidants and periodontal disease status', PROCEEDINGS OF THE NUTRITION SOCIETY, 61 137-143 (2002)
|Show 24 more journal articles|
Conference (6 outputs)
Coda A, Fellas A, Sculley D, Santos D, Girones X, Brosseau L, et al., 'Smart Technologies To Improve Health Outcomes In Juvenile Idiopathic Arthritis', Athens, Greece (2017)
|2005||Langley-Evans SC, Sculley DV, 'Survival of male rats is unaltered by exposure to a maternal low protein diet during specific periods of intrauterine development', PEDIATRIC RESEARCH, Toronto, CANADA (2005)|
Sculley DV, Langley-Evans SC, 'Programmed deterioration of renal function is exacerbated by a disruption in the glutathione redox system', PEDIATRIC RESEARCH, Toronto, CANADA (2005)
|2003||Langley-Evans S, Sculley D, McMullen S, 'Increased oxidative injury in the liver of newborn rats exposed to intrauterine undernutrition is associated with reduced activity of superoxide dismutase.', PEDIATRIC RESEARCH, BRIGHTON, ENGLAND (2003)|
|2003||Sculley DV, Langley-Evans SC, 'Salivary antioxidant status is independent of dietary intake.', FREE RADICAL RESEARCH, LOANNINA, GREECE (2003)|
|2003||Sculley DV, Langley-Evans SC, 'Periodontal disease is associated with lower antioxidant capacity in whole saliva and evidence of increased protein oxidation.', FREE RADICAL RESEARCH, LOANNINA, GREECE (2003)|
|Show 3 more conferences|
Grants and Funding
|Number of grants||2|
Click on a grant title below to expand the full details for that specific grant.
20172 grants / $15,000
Randomised control trial of smart-watch technology for improving pain, quality of life, drug-therapy & physical-activity adherence in children with Juvenile Arthritis (Invited Woodend application)$11,000
Funding body: Perpetual Limited
|Funding body||Perpetual Limited|
|Project Team||Doctor Andrea Coda, Doctor Dean Sculley, Doctor Gabor Major, Dr Xavier Girones, Dr Derek Santos, Dr Jeffrey Chaitow, Professor Lucie Brosseau, Professor Derek Smith, Professor Keith Rome, Professor Joshua Burns, Associate Professor Davinder Singh-Grewal|
|Scheme||Impact Philanthropy Program|
|Type Of Funding||C3111 - Aust For profit|
Funding body: Auckland University of Technology
|Funding body||Auckland University of Technology|
|Project Team||Doctor Andrea Coda, Doctor Dean Sculley, Dr Xavier Girones, Dr Derek Santos, Dr Jeffrey Chaitow, Professor Derek Smith, Professor Keith Rome, Professor Joshua Burns, Associate Professor Davinder Singh-Grewal|
|Type Of Funding||C3212 - International Not for profit|
Number of supervisions
Total current UON EFTSL
|Commenced||Level of Study||Research Title||Program||Supervisor Type|
|2018||PhD||The Interactions Between Taste Receptors, the Oral Microbiome, Diet and Risk for Obesity and Markers of Metabolic Diseases||PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle||Co-Supervisor|
|2014||PhD||Training responses in females||PhD (Exercise & Sport Science), Faculty of Science, The University of Newcastle||Co-Supervisor|
|Year||Level of Study||Research Title||Program||Supervisor Type|
|2016||PhD||Performance, Physiological and Perceptual Effects of Cooling Endurance Athletes in the Heat||PhD (Exercise & Sport Science), Faculty of Science, The University of Newcastle||Co-Supervisor|
|2016||PhD||The Acute Physiological Physical and Perceptual Responses to Intermittent Hypoxic Resistance Training||PhD (Exercise & Sport Science), Faculty of Science, The University of Newcastle||Co-Supervisor|
Dr Dean Sculley
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
Centre for English Language and Foundation Studies
|Phone||(02) 4349 4596|
|Fax||(02) 4349 4538|
10 Chittaway Road
Ourimbah, NSW 2258