Dr Tessa Lord
ARC DECRA
Office PVC - Engineering, Science and Environment
- Email:tessa.lord@newcastle.edu.au
- Phone:(02) 40553026
Career Summary
Biography
I am a Senior Lecturer in Biological Sciences and ARC DECRA Fellow in the Priority Research Centre for Reproductive Science. My research is primarily focused on understanding how the stem cells in the testis function to drive sperm production, and on harnessing this knowledge to support stem cell maintenance in an in vitro environment. The ability to maintain spermatogonial stem cells in in vitro holds potential benefits for both medical research and wildlife conservation. In humans, such techniques may allow stem cells from the testis to be used as a therapeutic tool to treat infertility caused by chemotherapy and radiotherapy treatments, particularly in pre-pubertal boys who currently have no other options to safeguard their fertility. In vulnerable and endangered wildlife species, biobanking of spermatogonial stem cells may provide a pathway to maintain genetically diverse and thus, more robust, populations.
I completed my PhD under the supervision of L. Prof. John Aitken and Prof. Brett Nixon at the University of Newcastle in October 2015. My doctoral studies were focused on understanding the molecular processes that drive the rapid demise of the oocyte (egg) in the culture dish, prior to its utilization for IVF. In working with members of the PRC in Reproductive Science, we identified that oxidative stress as a key factor instigating oocyte degeneration, and demonstrated that supplementation of oocyte culture media with the antioxidant melatonin could prolong the window for fertilization and improve the quality the embryos produced.
Following my PhD, I moved to Washington State University, USA, where I worked as a Postdoctoral fellow for 3 years under the supervision of Prof. Jon Oatley. As a member of the Centre for Reproductive Biology at WSU, I conducted research on spermatogonial stem cells, with a particular focus on identifying transcription factors that regulate stem cell maintenance and self-renewal, and on developing novel high-throughput methodologies that can be used to study the stem cell pool.
My current research areas of interest include:
1. Understanding the microenvironment within which stem cells reside in the testis, with a particular interest in oxygen tension
2. Identifying/characterising molecular networks that regulate self-renewal of spermatogonial stem cells, including oxygen-responsive transcription factors and factors involved in metabolic regulation
3. Adapting culture conditions to facilitate robust maintenance and proliferation of spermatogonial stem cells in vitro, allowing for transplantation that could potentially restore sperm production in an infertile testis
4. Understanding the biology of spermatogonial stem cells from the testes of Australian native wildlife species, such as the Koala and Echidna
Qualifications
- Doctor of Philosophy, University of Newcastle
- Bachelor of Biotechnology, University of Newcastle
- Bachelor of Biotechnology (Honours), University of Newcastle
Keywords
- Fertility
- Reproduction
- Reproductive biology
- Stem cells
- Wildlife conservation
Languages
- English (Mother)
Fields of Research
Code | Description | Percentage |
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321503 | Reproduction | 80 |
310102 | Cell development, proliferation and death | 20 |
Professional Experience
UON Appointment
Title | Organisation / Department |
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Senior Lecturer | University of Newcastle School of Environmental and Life Sciences Australia |
Academic appointment
Dates | Title | Organisation / Department |
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21/1/2019 - 31/12/2022 | Lecturer in Biological Sciences | College of Engineering, Science and Environment, University of Newcastle Australia |
30/10/2015 - 30/12/2018 | Postdoctoral researcher | Washington State University Centre for Reproductive Biology, School of Molecular Biosciences United States |
Awards
Award
Year | Award |
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2022 |
Finalist - Society for Reproductive Biology (SRB) Newcastle Reproduction Emerging Research Leader Award Society for Reproductive Biology |
2022 |
Society for Reproductive Biology (SRB) Male Contraceptive Initiative abstract award Society for Reproductive Biology |
2020 |
2020 PVC Conference Assistance Funding University of Newcastle |
2020 |
Women in STEMM ECR PhD scholarship University of Newcastle |
2019 |
2019 PVC Conference Assistance Funding Faculty of Science | University of Newcastle |
2017 |
Winner of ‘Best Presentation by a Postdoc’ travel award, WSU SMB retreat Washington State University |
2015 |
Selected for ‘Frontiers in Stem Cells in Cancer’ advanced training course Frontiers in Stem Cells in Cancer |
2014 |
Faculty of Science and I.T. Conference Scholarship Faculty of Science and Information Technology, University of Newcastle |
2014 |
‘Best Presentation by a PhD Student’ prize - ASMR satellite meeting Australian Society for Medical Research (ASMR) |
2013 |
SRB ‘Oozoa award’ for best student presentation Australian Society for Reproductive Biology |
2012 |
Australian Postgraduate Award PhD Scholarship Faculty of Science and Information Technology, University of Newcastle |
2011 |
Don Angus Memorial Prize for Molecular Biology Faculty of Science and Information Technology, University of Newcastle |
2011 |
School of Environmental and Life Sciences ‘Summer Research Scholarship’ Faculty of Science and Information Technology, University of Newcastle |
2011 |
Faculty of Science and I.T. Honours Scholarship Faculty of Science and Information Technology, University of Newcastle |
2011 |
Deputy Vice-Chancellor Research and Innovation (Honours) Scholarship Faculty of Science and Information Technology, University of Newcastle |
Distinction
Year | Award |
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2011 |
University medal for exceptional academic merit Faculty of Science and Information Technology, The University of Newcastle |
2011 |
Faculty Medal for exceptional academic merit Faculty of Science and Information Technology, University of Newcastle |
Prize
Year | Award |
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2021 |
Hudson Institute of Medical Research award for best MCR poster Australian Society for Reproductive Biology |
Recognition
Year | Award |
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2019 |
Finalist (top 20 shortlisted candidate) – Australian Women’s Weekly STEMSTART grant Australian Women's Weekly |
Invitations
Keynote Speaker
Year | Title / Rationale |
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2024 | Fertility 2024 |
2023 | Germinal Stem Cell Biology Gordon Research Seminar (GRS) |
Speaker
Year | Title / Rationale |
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2023 | 1st Spermatogenesis conference |
2023 | Germinal Stem Cell Biology Gordon Research Conference (GRC) |
2022 | University of Sydney Ecology Evolution Conservation (EEC) seminar series |
2022 | American Society for Andrology (ASA) |
2021 | Flinders University Health and Medical Research Institute Seminar Series |
2018 | Gordon Research Conference on Mammalian Reproduction |
Teaching
Code | Course | Role | Duration |
---|---|---|---|
BIOL2050 |
Molecular Genetics Faculty of Science | University of Newcastle |
Lecturer | 21/1/2019 - 31/12/2021 |
BIOL2002 |
Laboratory Skills in Biological Systems Faculty of Science | University of Newcastle |
Lecturer | 21/1/2019 - 31/12/2020 |
BIOL2010 |
Biochemistry Faculty of Science | University of Newcastle |
Lecturer | 21/1/2019 - 31/12/2021 |
BIOL2001 |
Molecular Laboratory Skills for the Biological Sciences Faculty of Science | University of Newcastle |
Lecturer | 21/1/2021 - 31/12/2023 |
BIOL3020 |
Reproductive Physiology and Development Faculty of Science | University of Newcastle |
Lecturer | 21/1/2019 - 31/12/2021 |
Publications
For publications that are currently unpublished or in-press, details are shown in italics.
Chapter (3 outputs)
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2018 |
Lord T, Oatley JM, 'Spermatogonial response to somatic cell interactions', Encyclopedia of Reproduction 53-58 (2018) The spermatogonial population must maintain a balance between self-renewal and differentiation for continuity of the spermatogenic lineage and therefore fertility. Extrinsic signa... [more] The spermatogonial population must maintain a balance between self-renewal and differentiation for continuity of the spermatogenic lineage and therefore fertility. Extrinsic signals emanating from the somatic cell populations in the testes are intricately involved in regulating fate decisions in the undifferentiated and differentiating spermatogonial pools. Importantly, these signals not only originate from Sertoli cells that are considered to be a part of the SSC niche, but also from somatic cells on the surface of the seminiferous tubule and those residing in the interstitium. This review provides an overview of known interactions between spermatogonia and a number of somatic cell type in the testis; including the Sertoli, Leydig, peritubular myoid, macrophage and vascular cells. In particular, we focus on the production of growth factors by these somatic cells that have the capacity to stimulate maintenance of the undifferentiated spermatogonial population as well as self-renewal of spermatogonial stem cells (SSCs). Further, we review the capacity for somatic cell signals to regulate the differentiating transition in the spermatogonial pool via tight control over the synthesis and degradation of the differentiating signal; retinoic acid (RA). This review highlights the intricate and dichotomous role of somatic cells in regulating activities of the spermatogonial population; describing how, depending on the stage of the epithelial cycle, the same somatic cells that support maintenance of the undifferentiated population can instigate entry of these spermatogonia into the differentiating pathway that will culminate in the production of mature male gametes.
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2018 | Lord T, Oatley JM, 'Spermatogonial Response to Somatic Cell Interactions. Volume 3: Gametogenesis, Fertilization and Early Development - Spermatogenesis', Encyclopedia of Reproduction Second Edition, Academic Press, Cambridge, USA 53-53 (2018) | |||||||
2017 |
Lord T, Oatley JM, 'Regulation of spermatogonial stem cell maintenance and self-Renewal', The Biology of Mammalian Spermatogonia 91-129 (2017) Spermatogonial stem cells (SSCs) reside within the stem cell niche along the basement membrane of the seminiferous tubules in the testis, and their actions provide the basis for c... [more] Spermatogonial stem cells (SSCs) reside within the stem cell niche along the basement membrane of the seminiferous tubules in the testis, and their actions provide the basis for continuity and regeneration of the spermatogenic lineage. SSCs must balance self-renewal with the production of progenitor spermatogonia in order to sustain optimal sperm production while preventing exhaustion of the stem cell reservoir. Regulation of SSC fate decision is in part influenced by signaling from growth factors, such as Gdnf and Fgf2, which are synthesized by somatic niche support cells. Such growth factors have been shown to directly influence expression of transcription factors such as Id4, Etv5, and Bcl6b within SSCs to stimulate self-renewal. Additionally, the undifferentiated state of both SSCs and progenitors is maintained by virtue of intracellular regulation at transcriptional, translational, and posttranslational levels; both independently and dependently of characterized growth factors released from the niche. This intrinsic regulation not only acts to enrich the expression of genes important for maintaining the undifferentiated state, but also supresses expression of differentiation-driving factors. Although progress in SSC research has previously been dampened by a lack of SSC-specific markers that can be used to isolate pure populations for analysis, recent advances have seen the development of mouse lines in which the SSC population alone is marked by expression of a fluorescent reporter transgene; for example the Id4-eGfp mouse line. Consequently, in-depth analysis of the SSC population in comparison to undifferentiated progenitors and differentiating spermatogonia is now possible. Further progress in characterizing factors involved in SSC maintenance and self-renewal is important for understanding potential underlying causes of idiopathic infertility, and further, is the basis for developing therapeutic strategies aimed at reinstating fertility in patients who have been rendered infertile as a consequence of chemotherapeutic treatments in pre-pubertal life.
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Journal article (33 outputs)
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2024 |
Mulhall JE, Trigg NA, Bernstein IR, Anderson AL, Murray HC, Sipilä P, et al., 'Immortalized mouse caput epididymal epithelial (mECap18) cell line recapitulates the in-vivo environment.', Proteomics, 24 e2300253 (2024) [C1]
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2024 |
Skerrett-Byrne DA, Stanger SJ, Trigg NA, Anderson AL, Sipila P, Bernstein IR, et al., 'Phosphoproteomic analysis of the adaption of epididymal epithelial cells to corticosterone challenge', ANDROLOGY, [C1]
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2023 |
Nixon B, Schjenken JE, Burke ND, Skerrett-Byrne DA, Hart HM, De Iuliis GN, et al., 'New horizons in human sperm selection for assisted reproduction', Frontiers in Endocrinology, 14 (2023) [C1] Male infertility is a commonly encountered pathology that is estimated to be a contributory factor in approximately 50% of couples seeking recourse to assisted reproductive techno... [more] Male infertility is a commonly encountered pathology that is estimated to be a contributory factor in approximately 50% of couples seeking recourse to assisted reproductive technologies. Upon clinical presentation, such males are commonly subjected to conventional diagnostic andrological practices that rely on descriptive criteria to define their fertility based on the number of morphologically normal, motile spermatozoa encountered within their ejaculate. Despite the virtual ubiquitous adoption of such diagnostic practices, they are not without their limitations and accordingly, there is now increasing awareness of the importance of assessing sperm quality in order to more accurately predict a male¿s fertility status. This realization raises the important question of which characteristics signify a high-quality, fertilization competent sperm cell. In this review, we reflect on recent advances in our mechanistic understanding of sperm biology and function, which are contributing to a growing armory of innovative approaches to diagnose and treat male infertility. In particular we review progress toward the implementation of precision medicine; the robust clinical adoption of which in the setting of fertility, currently lags well behind that of other fields of medicine. Despite this, research shows that the application of advanced technology platforms such as whole exome sequencing and proteomic analyses hold considerable promise in optimizing outcomes for the management of male infertility by uncovering and expanding our inventory of candidate infertility biomarkers, as well as those associated with recurrent pregnancy loss. Similarly, the development of advanced imaging technologies in tandem with machine learning artificial intelligence are poised to disrupt the fertility care paradigm by advancing our understanding of the molecular and biological causes of infertility to provide novel avenues for future diagnostics and treatments.
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2023 |
Cason C, Lord T, 'RNA Interference as a Method of Gene Knockdown in Cultured Spermatogonia.', Methods Mol Biol, 2656 161-177 (2023) [C1]
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2023 |
Bernstein IR, Nixon B, Lyons JM, Damyanova KB, De Oliveira CS, Mabotuwana NS, et al., 'The hypoxia-inducible factor EPAS1 is required for spermatogonial stem cell function in regenerative conditions', iScience, 26 108424-108424 (2023) [C1]
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2022 |
Lord T, Law NC, Oatley MJ, Miao D, Du G, Oatley JM, 'A novel high throughput screen to identify candidate molecular networks that regulate spermatogenic stem cell functions
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2022 |
De Oliveira CS, Nixon B, Lord T, 'A scRNA-seq Approach to Identifying Changes in Spermatogonial Stem Cell Gene Expression Following in vitro Culture', FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 10 (2022) [C1]
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2022 |
Martin JH, Nixon B, Cafe SL, Aitken RJ, Bromfield EG, Lord T, 'OXIDATIVE STRESS AND REPRODUCTIVE FUNCTION: Oxidative stress and in vitro ageing of the post-ovulatory oocyte: an update on recent advances in the field', REPRODUCTION, 164 F109-F124 (2022) [C1]
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2021 |
Cafe SL, Skerrett-Byrne DA, De Oliveira CS, Nixon B, Oatley MJ, Oatley JM, Lord T, 'A regulatory role for CHD4 in maintenance of the spermatogonial stem cell pool', STEM CELL REPORTS, 16 1555-1567 (2021) [C1]
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2021 |
Skerrett-Byrne DA, Trigg NA, Bromfield EG, Dun MD, Bernstein IR, Anderson AL, et al., 'Proteomic dissection of the impact of environmental exposures on mouse seminal vesicle function', Molecular and Cellular Proteomics, 20 (2021) [C1] Seminal vesicles are an integral part of the male reproductive accessory gland system. They produce a complex array of secretions containing bioactive constituents that support ga... [more] Seminal vesicles are an integral part of the male reproductive accessory gland system. They produce a complex array of secretions containing bioactive constituents that support gamete function and promote reproductive success, with emerging evidence suggesting these secretions are influenced by our environment. Despite their significance, the biology of seminal vesicles remains poorly defined. Here, we complete the first proteomic assessment of mouse seminal vesicles and assess the impact of the reproductive toxicant acrylamide. Mice were administered acrylamide (25 mg/kg bw/day) or control daily for five consecutive days prior to collecting seminal vesicle tissue. A total of 5013 proteins were identified in the seminal vesicle proteome with bioinformatic analyses identifying cell proliferation, protein synthesis, cellular death, and survival pathways as prominent biological processes. Secreted proteins were among the most abundant, and several proteins are linked with seminal vesicle phenotypes. Analysis of the effect of acrylamide on the seminal vesicle proteome revealed 311 differentially regulated (FC ± 1.5, p = 0.05, 205 up-regulated, 106 downregulated) proteins, orthogonally validated via immunoblotting and immunohistochemistry. Pathways that initiate protein synthesis to promote cellular survival were prominent among the dysregulated pathways, and rapamycin-insensitive companion of mTOR (RICTOR, p = 6.69E-07) was a top-ranked upstream driver. Oxidative stress was implicated as contributing to protein changes, with acrylamide causing an increase in 8-OHdG in seminal vesicle epithelial cells (fivefold increase, p = 0.016) and the surrounding smooth muscle layer (twofold increase, p = 0.043). Additionally, acrylamide treatment caused a reduction in seminal vesicle secretion weight (36% reduction, p = 0.009) and total protein content (25% reduction, p = 0.017). Together these findings support the interpretation that toxicant exposure influences male accessory gland physiology and highlights the need to consider the response of all male reproductive tract tissues when interpreting the impact of environmental stressors on male reproductive function.
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2021 |
Skerrett-Byrne DA, Nixon B, Bromfield EG, Breen J, Trigg NA, Stanger SJ, et al., 'Transcriptomic analysis of the seminal vesicle response to the reproductive toxicant acrylamide', BMC Genomics, 22 (2021) [C1] Background: The seminal vesicles synthesise bioactive factors that support gamete function, modulate the female reproductive tract to promote implantation, and influence developme... [more] Background: The seminal vesicles synthesise bioactive factors that support gamete function, modulate the female reproductive tract to promote implantation, and influence developmental programming of offspring phenotype. Despite the significance of the seminal vesicles in reproduction, their biology remains poorly defined. Here, to advance understanding of seminal vesicle biology, we analyse the mouse seminal vesicle transcriptome under normal physiological conditions and in response to acute exposure to the reproductive toxicant acrylamide. Mice were administered acrylamide (25 mg/kg bw/day) or vehicle control daily for five consecutive days prior to collecting seminal vesicle tissue 72 h following the final injection. Results: A total of 15,304 genes were identified in the seminal vesicles with those encoding secreted proteins amongst the most abundant. In addition to reproductive hormone pathways, functional annotation of the seminal vesicle transcriptome identified cell proliferation, protein synthesis, and cellular death and survival pathways as prominent biological processes. Administration of acrylamide elicited 70 differentially regulated (fold-change =1.5 or = 0.67) genes, several of which were orthogonally validated using quantitative PCR. Pathways that initiate gene and protein synthesis to promote cellular survival were prominent amongst the dysregulated pathways. Inflammation was also a key transcriptomic response to acrylamide, with the cytokine, Colony stimulating factor 2 (Csf2) identified as a top-ranked upstream driver and inflammatory mediator associated with recovery of homeostasis. Early growth response (Egr1), C-C motif chemokine ligand 8 (Ccl8), and Collagen, type V, alpha 1 (Col5a1) were also identified amongst the dysregulated genes. Additionally, acrylamide treatment led to subtle changes in the expression of genes that encode proteins secreted by the seminal vesicle, including the complement regulator, Complement factor b (Cfb). Conclusions: These data add to emerging evidence demonstrating that the seminal vesicles, like other male reproductive tract tissues, are sensitive to environmental insults, and respond in a manner with potential to exert impact on fetal development and later offspring health.
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2021 |
Nixon B, Anderson AL, Bromfield EG, Martin JH, Lord T, Cafe SL, et al., 'Gross and microanatomy of the male reproductive duct system of the saltwater crocodile Crocodylus porosus', REPRODUCTION FERTILITY AND DEVELOPMENT, 33 540-554 (2021) [C1]
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2020 |
Winship A, Donoghue J, Houston BJ, Martin JH, Lord T, Adwal A, et al., 'Reproductive health research in Australia and New Zealand: Highlights from the Annual Meeting of the Society for Reproductive Biology, 2019', Reproduction, Fertility and Development, 32 637-647 (2020) [C1]
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2020 |
Lee AK, Klein J, Tacer KF, Lord T, Oatley MJ, Oatley JM, et al., 'Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance', MOLECULAR CELL, 79 645-+ (2020) [C1]
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2020 |
Lord T, Nixon B, 'Metabolic Changes Accompanying Spermatogonial Stem Cell Differentiation', Developmental Cell, 52 399-411 (2020) [C1]
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2019 |
Martin JH, Aitken RJ, Bromfield E, Cafe SL, Sutherland JM, Frost ER, et al., 'Investigation into the presence and functional significance of proinsulin C-peptide in the female germline', Biology of Reproduction, 100 1275-1289 (2019) [C1]
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2019 |
Tacer KF, Montoya MC, Oatley MJ, Lord T, Oatley JM, Klein J, et al., 'MAGE cancer-testis antigens protect the mammalian germline under environmental stress', SCIENCE ADVANCES, 5 (2019) [C1]
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2019 |
Nixon B, Bernstein IR, Cafe SL, Delehedde M, Sergeant N, Anderson AL, et al., 'A Kinase Anchor Protein 4 is vulnerable to oxidative adduction in male germ cells', Frontiers in Cell and Developmental Biology, 7 (2019) [C1]
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2018 |
Martin J, Bromfield EG, Aitken RJ, Lord T, Nixon B, 'Double Strand Break DNA Repair occurs via Non-Homologous End-Joining in Mouse MII Oocytes', Scientific Reports, 8 1-15 (2018) [C1]
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2018 |
Lord T, Oatley JM, 'Functional assessment of spermatogonial stem cell purity in experimental cell populations', STEM CELL RESEARCH, 29 129-133 (2018) [C1]
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2018 |
Lord T, Oatley MJ, Oatley JM, 'Testicular Architecture Is Critical for Mediation of Retinoic Acid Responsiveness by Undifferentiated Spermatogonial Subtypes in the Mouse', STEM CELL REPORTS, 10 538-552 (2018) [C1]
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2017 |
Helsel AR, Yang Q-E, Oatley MJ, Lord T, Sablitzky F, Oatley JM, 'ID4 levels dictate the stem cell state in mouse spermatogonia', DEVELOPMENT, 144 624-634 (2017) [C1]
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2017 |
Lord T, Oatley JM, 'A revised A(single) model to explain stem cell dynamics in the mouse male germline', REPRODUCTION, 154 R55-R64 (2017) [C1]
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2016 |
Martin JH, Nixon B, Lord T, Bromfield EG, Aitken RJ, 'Identification of a key role for permeability glycoprotein in enhancing the cellular defense mechanisms of fertilized oocytes', DEVELOPMENTAL BIOLOGY, 417 63-76 (2016) [C1]
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2015 |
Lord T, Martin JH, Aitken RJ, 'Accumulation of Electrophilic Aldehydes During Postovulatory Aging of Mouse Oocytes Causes Reduced Fertility, Oxidative Stress, and Apoptosis', BIOLOGY OF REPRODUCTION, 92 (2015) [C1]
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2015 |
Lord T, Aitken RJ, 'Fertilization stimulates 8-hydroxy-2'-deoxyguanosine repair and antioxidant activity to prevent mutagenesis in the embryo', Developmental Biology, 406 1-13 (2015) [C1] Oxidative DNA damage harbored by both spermatozoa and oocytes at the time of fertilization must be repaired prior to S-phase of the first mitotic division to reduce the risk of tr... [more] Oxidative DNA damage harbored by both spermatozoa and oocytes at the time of fertilization must be repaired prior to S-phase of the first mitotic division to reduce the risk of transversion mutations occurring in the zygote and subverting the normal patterns of cell differentiation and development. Of the characterised oxidative DNA lesions, 8-hydroxy-2'-deoxyguanosine (8OHdG) is particularly mutagenic. The current study reveals for the first time a marked acceleration of 8OHdG repair in the mouse oocyte/zygote by the base excision repair (BER) pathway following fertilization. Specifically, fertilization initiates post-translational modification to BER enzymes such as OGG1 and XRCC1, causing nuclear localisation and accelerated 8OHdG excision. Additionally, both the nuclear and mitochondrial genomes appear to benefit from increased protection against further 8OHdG formation by a fertilization-associated increase in glutathione peroxidase activity. The major limitation of the characterised 8OHdG repair system is the relatively low level of OGG1 expression in the oocyte, in contrast to the male germ line where it is the only constituent of the BER pathway. The male and female germ lines therefore collaborate in the repair of oxidative DNA damage, and oocytes are vulnerable to high levels of 8OHdG being carried into the zygote by the fertilizing spermatozoon.
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2013 |
Lord T, Nixon B, Jones KT, Aitken RJ, 'Melatonin Prevents Postovulatory Oocyte Aging in the Mouse and Extends the Window for Optimal Fertilization In Vitro', Biology of Reproduction, 88 1-9 (2013) [C1]
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2013 |
Smith TB, De Iuliis GN, Lord T, Aitken RJ, 'The senescence-accelerated mouse prone 8 as a model for oxidative stress and impaired DNA repair in the male germ line', Reproduction, 146 253-262 (2013) [C1]
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2013 |
Lord T, Aitken RJ, 'Oxidative stress and ageing of the post-ovulatory oocyte', Reproduction, 146 217-227 (2013) [C1]
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2013 |
Aitken RJ, Smith TB, Lord T, Kuczera L, Koppers AJ, Naumovski N, et al., 'On methods for the detection of reactive oxygen species generation by human spermatozoa: analysis of the cellular responses to catechol oestrogen, lipid aldehyde, menadione and arachidonic acid', Andrology, 1 192-205 (2013) [C1]
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2012 |
Reid AT, Lord T, Stanger SJ, Roman SD, McCluskey A, Robinson PJ, et al., 'Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa', Journal of Biological Chemistry, 287 37659-37672 (2012) [C1]
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Show 30 more journal articles |
Conference (1 outputs)
Year | Citation | Altmetrics | Link | |||||
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2014 |
Lord T, Martin JH, Aitken RJ, 'ACCUMULATION OF 4-HYDROXYNONENAL DURING POST-OVULATORY AGEING OF MOUSE OOCYTES CAUSES REDUCED FERTILITY, OXIDATIVE STRESS AND APOPTOSIS.', FERTILITY AND STERILITY, Honolulu, HI (2014) [E3]
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Preprint (1 outputs)
Year | Citation | Altmetrics | Link | ||
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2020 |
Lee AK, Klein J, Tacer KF, Lord T, Oatley MJ, Oatley JM, et al., 'Enhanced stress tolerance through reduction of G3BP and suppression of stress granules (2020)
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Thesis / Dissertation (1 outputs)
Year | Citation | Altmetrics | Link |
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2015 | Lord T, The role of reactive oxygen species and oxidative stress in post-ovulatory ageing and apoptosis of the mammalian oocyte, University of Newcastle (2015) |
Grants and Funding
Summary
Number of grants | 25 |
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Total funding | $2,284,300 |
Click on a grant title below to expand the full details for that specific grant.
20241 grants / $983,388
Targeting the epididymis to protect the integrity of the sperm epigenome$983,388
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
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Project Team | CIA Brett Nixon |
Scheme | Ideas Grants |
Role | Investigator |
Funding Start | 2024 |
Funding Finish | 2027 |
GNo | |
Type Of Funding | C1100 - Aust Competitive - NHMRC |
Category | 1100 |
UON | N |
20231 grants / $24,648
NHMRC Equipment Grant$24,648
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Dr John Schjenken, Prof Brett Nixon, Dr Jacinta Martin |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2023 |
Funding Finish | 2023 |
GNo | |
Type Of Funding | C1100 - Aust Competitive - NHMRC |
Category | 1100 |
UON | N |
20221 grants / $408,802
Banking on spermatogonial stem cells to safeguard Australian native fauna$408,802
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Doctor Tessa Lord |
Scheme | Discovery Early Career Researcher Award (DECRA) |
Role | Lead |
Funding Start | 2022 |
Funding Finish | 2024 |
GNo | G2001134 |
Type Of Funding | C1200 - Aust Competitive - ARC |
Category | 1200 |
UON | Y |
20212 grants / $24,953
CESE EQUIPMENT AND INFRASTRUCTURE INVESTMENT SCHEME (2021)$21,953
Funding body: College of Engineering, Science and Environment, UON
Funding body | College of Engineering, Science and Environment, UON |
---|---|
Scheme | CESE EQUIPMENT AND INFRASTRUCTURE INVESTMENT SCHEME (2021) |
Role | Investigator |
Funding Start | 2021 |
Funding Finish | 2021 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
2021 College Lockdown support scheme for Academic Staff$3,000
Funding body: College of Engineering, Science and Environment, University of Newcastle
Funding body | College of Engineering, Science and Environment, University of Newcastle |
---|---|
Scheme | Lockdown support scheme |
Role | Lead |
Funding Start | 2021 |
Funding Finish | 2021 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
20203 grants / $630,634
Investigating the role of hypoxic niche microenvironments and hypoxia-induced transcription factors in regulating spermatogonial stem cell function$574,979
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Doctor Tessa Lord, Professor Brett Nixon |
Scheme | Ideas Grants |
Role | Lead |
Funding Start | 2020 |
Funding Finish | 2022 |
GNo | G1900404 |
Type Of Funding | C1100 - Aust Competitive - NHMRC |
Category | 1100 |
UON | Y |
ChemiDoc Imaging System$53,721
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Doctor Tessa Lord, Doctor Jessie Sutherland, Doctor Elizabeth Bromfield, Laureate Professor John Aitken, Doctor Geoffry De Iuliis, Professor Brett Nixon |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2020 |
Funding Finish | 2020 |
GNo | |
Type Of Funding | Scheme excluded from IGS |
Category | EXCL |
UON | N |
Faculty Output Accelerator Initiative$1,934
Funding body: Faculty of Science | University of Newcastle
Funding body | Faculty of Science | University of Newcastle |
---|---|
Scheme | Faculty Output Accelerator Initiative |
Role | Lead |
Funding Start | 2020 |
Funding Finish | 2020 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
20195 grants / $44,938
Novel strategies to reverse chemotherapy-induced infertility in male childhood cancer survivors$28,500
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Doctor Tessa Lord |
Scheme | Research Grant |
Role | Lead |
Funding Start | 2019 |
Funding Finish | 2020 |
GNo | G1901485 |
Type Of Funding | C3300 – Aust Philanthropy |
Category | 3300 |
UON | Y |
Faculty of Science Strategic Investment Funding$8,000
Funding body: Faculty of Science and IT, University of Newcastle
Funding body | Faculty of Science and IT, University of Newcastle |
---|---|
Scheme | Faculty of Science Strategic Investment Grant |
Role | Lead |
Funding Start | 2019 |
Funding Finish | 2019 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
PRC for Reproductive Science Pilot Project Funding$5,000
Funding body: PRC for Reproductive Science, University of Newcastle
Funding body | PRC for Reproductive Science, University of Newcastle |
---|---|
Scheme | Pilot project funding |
Role | Lead |
Funding Start | 2019 |
Funding Finish | 2019 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
2019 PVC Conference Assistance Funding$2,000
Funding body: Faculty of Science | University of Newcastle | Australia
Funding body | Faculty of Science | University of Newcastle | Australia |
---|---|
Scheme | PVC Conference Assistance Funding |
Role | Lead |
Funding Start | 2019 |
Funding Finish | 2019 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
GRC for Germinal Stem Cell Biology travel grant$1,438
Funding body: Gordon Research Conferences
Funding body | Gordon Research Conferences |
---|---|
Scheme | GRC for Germinal Stem Cell Biology travel grant |
Role | Lead |
Funding Start | 2019 |
Funding Finish | 2019 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
20181 grants / $420
WSU Centre for Reproductive Biology travel award$420
Funding body: Centre for Reproductive Biology, WSU
Funding body | Centre for Reproductive Biology, WSU |
---|---|
Scheme | WSU Centre for Reproductive Biology travel award |
Role | Lead |
Funding Start | 2018 |
Funding Finish | 2019 |
GNo | |
Type Of Funding | C3211 - International For profit |
Category | 3211 |
UON | N |
20174 grants / $71,470
Lalor Foundation Postdoctoral Fellowship$70,000
Funding body: Lalor Foundation
Funding body | Lalor Foundation |
---|---|
Project Team | Tessa Lord, Jon Oatley |
Scheme | Lalor Foundation Postdoctoral Fellowship |
Role | Lead |
Funding Start | 2017 |
Funding Finish | 2018 |
GNo | |
Type Of Funding | C3212 - International Not for profit |
Category | 3212 |
UON | N |
North American Testis Workshop speaker selection/travel award$700
Funding body: American Society of Andrology
Funding body | American Society of Andrology |
---|---|
Scheme | North American Testis Workshop speaker selection/travel award |
Role | Lead |
Funding Start | 2017 |
Funding Finish | 2018 |
GNo | |
Type Of Funding | C3211 - International For profit |
Category | 3211 |
UON | N |
WSU Centre for Reproductive Biology travel award$420
Funding body: Centre for Reproductive Biology, WSU
Funding body | Centre for Reproductive Biology, WSU |
---|---|
Scheme | WSU Centre for Reproductive Biology travel award |
Role | Lead |
Funding Start | 2017 |
Funding Finish | 2018 |
GNo | |
Type Of Funding | C3211 - International For profit |
Category | 3211 |
UON | N |
WSU School of Molecular Biosciences travel award$350
Funding body: School of Molecular Biosciences, WSU
Funding body | School of Molecular Biosciences, WSU |
---|---|
Scheme | WSU School of Molecular Biosciences travel award |
Role | Lead |
Funding Start | 2017 |
Funding Finish | 2018 |
GNo | |
Type Of Funding | C3211 - International For profit |
Category | 3211 |
UON | N |
20161 grants / $700
Northwest Reproductive Sciences symposium travel award$700
Funding body: Northwest Reproductive Sciences Symposium and Centre for Reproductive Biology, WSU
Funding body | Northwest Reproductive Sciences Symposium and Centre for Reproductive Biology, WSU |
---|---|
Scheme | NWRSS/CRB travel award |
Role | Lead |
Funding Start | 2016 |
Funding Finish | 2017 |
GNo | |
Type Of Funding | C3211 - International For profit |
Category | 3211 |
UON | N |
20152 grants / $3,650
Frontiers in Stem Cells in Cancer travel award$2,650
Funding body: Frontiers in Stem Cells in Cancer
Funding body | Frontiers in Stem Cells in Cancer |
---|---|
Scheme | Frontiers in Stem Cells in Cancer travel award |
Role | Lead |
Funding Start | 2015 |
Funding Finish | 2015 |
GNo | |
Type Of Funding | International - Competitive |
Category | 3IFA |
UON | N |
Faculty of Science and IT thesis submission scholarship$1,000
Funding body: Faculty of Science and Information Technology The University of Newcastle
Funding body | Faculty of Science and Information Technology The University of Newcastle |
---|---|
Scheme | FSCIT thesis submission scholarship |
Role | Lead |
Funding Start | 2015 |
Funding Finish | 2015 |
GNo | |
Type Of Funding | Not Known |
Category | UNKN |
UON | N |
20141 grants / $2,000
Faculty of Science and IT conference scholarship$2,000
Funding body: Faculty of Science and Information Technology The University of Newcastle
Funding body | Faculty of Science and Information Technology The University of Newcastle |
---|---|
Scheme | Faculty of Science and IT conference scholarship |
Role | Lead |
Funding Start | 2014 |
Funding Finish | 2014 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
20121 grants / $86,697
Australian Postgraduate Award$86,697
Funding body: Australian Commonwealth Government
Funding body | Australian Commonwealth Government |
---|---|
Scheme | Australian Postgraduate Award scholarship |
Role | Lead |
Funding Start | 2012 |
Funding Finish | 2015 |
GNo | |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | N |
20112 grants / $2,000
DVCR Honours Scholarship$1,000
Funding body: The University of Newcastle
Funding body | The University of Newcastle |
---|---|
Scheme | DVCR honours scholarship |
Role | Lead |
Funding Start | 2011 |
Funding Finish | 2012 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
Faculty of Science and IT Honours Scholarship$1,000
Funding body: Faculty of Science and Information Technology, University of Newcastle
Funding body | Faculty of Science and Information Technology, University of Newcastle |
---|---|
Scheme | FSCIT honours scholarship |
Role | Lead |
Funding Start | 2011 |
Funding Finish | 2011 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
Research Supervision
Number of supervisions
Current Supervision
Commenced | Level of Study | Research Title | Program | Supervisor Type |
---|---|---|---|---|
2024 | PhD | Investigating The Role of SIRT1 in Spermatogonial Stem Cell Function During Developmental and Regenerative Conditions | PhD (Biological Sciences), College of Engineering, Science and Environment, The University of Newcastle | Principal Supervisor |
2022 | PhD | Banking on Spermatogonial Stem Cells to Safeguard the Future of Australia’s Native Fauna | PhD (Biological Sciences), College of Engineering, Science and Environment, The University of Newcastle | Principal Supervisor |
2019 | PhD | Exploring Protein Aggregation in the Male Germ Line in Response to Oxidative Stress | PhD (Biological Sciences), College of Engineering, Science and Environment, The University of Newcastle | Co-Supervisor |
News
News • 17 Aug 2021
Funding success supports early career research translate to real-world
Five outstanding early career researchers have been successful in securing more than $2 million in the Australian Research Council’s Discovery Early Career Researcher Award (DECRA) scheme.
News • 19 May 2020
Unique Women in STEMM scholarship program supports Early Career Researchers
In a first for an Australian university to help redress some of the systemic biases female academics face, the University of Newcastle has awarded fully-funded PhD candidate scholarships to six Women in STEMM Early Career Researchers.
News • 18 Dec 2019
NHMRC awards $9.3 million to 13 University of Newcastle projects
The University of Newcastle has received more than $9.3 million in funding to support projects aiming to solve some of the world’s most critical health problems and improve the lives of millions of Australians.
Dr Tessa Lord
Position
ARC DECRA
PRC for Reproductive Sciences
Office PVC - Engineering, Science and Environment
College of Engineering, Science and Environment
Contact Details
tessa.lord@newcastle.edu.au | |
Phone | (02) 40553026 |
Links |
Twitter Research Networks |
Office
Room | LS4.38 |
---|---|
Building | Life Sciences Building |
Location | Callaghan University Drive Callaghan, NSW 2308 Australia |