Dr Robert Chapman

Dr Robert Chapman

Lecturer

School of Environmental and Life Sciences

Career Summary

Biography

I am a lecturer in chemistry in the School of Environmental and Life Sciences, and hold a joint appointment as an adjunct lecturer at the School of Chemistry at UNSW. I work on the use of high throughput polymerisation techniques to design polymer therapeutics, to control the folding of polymers into protein-like mimics, and to design polymers that will bind to proteins, enzymes and antibodies. I have expertise in a broad range of polymer chemistry, peptide driven self assembly, drug delivery, tissue engineering and in nanoparticle based biosensing.

Prior to joining the University of Newcastle, I completed a BEng in Industrial Chemistry (2002-07) at UNSW. After a year working in management consulting for the Boston Consulting Group, I moved to the University of Sydney for his PhD in Chemistry (2009-12) under Profs. Sebatien Perrier and Katrina Jolliffe, where I studied the synthesis and self assembly of cyclic peptide - polymer conjugates. I subsequently worked as a postdoctoral research associate in the lab of Prof. Molly Stevens at Imperial College London (2013-15) on the development of nanomaterial based biosensors and scaffolds for tissue engineering, before returning to the School of Chemistry at UNSW as a Vice-Chancellors Research Fellow (2016) and then Lecturer and DECRA fellow (2017-20). In 2020 I moved to the University of Newcastle as a lecturer in chemistry.

For further information see the group website here: www.chapmangroup.org


Qualifications

  • Doctor of Philosophy, University of Sydney
  • Bachelor of Engineering (Honours), University of New South Wales

Keywords

  • Biomaterials
  • Nanomedicine
  • Polymer chemistry

Fields of Research

Code Description Percentage
340308 Supramolecular chemistry 100

Professional Experience

UON Appointment

Title Organisation / Department
Lecturer University of Newcastle
School of Environmental and Life Sciences
Australia

Academic appointment

Dates Title Organisation / Department
1/1/2017 - 31/12/2020 Lecturer and DECRA fellow UNSW
School of Chemistry
Australia
1/1/2016 - 31/12/2016 Vice Chancellors Research Fellow UNSW
School of Chemistry
Australia
5/10/2012 - 31/12/2015 Postdoctoral Research Fellow Imperial College London
Department of Materials
United Kingdom

Teaching

Code Course Role Duration
CHEM2021 Organic chemistry
UNSW
Lecturer 1/1/2017 - 31/1/2020
CHEM2201 Analytical and Medicinal Chemistry
Discipline of Chemistry, University of Newcastle
Lecturer 1/7/2020 - 31/12/2020
CHEM2921 Food Chemistry
UNSW
Lecturer 1/1/2019 - 31/12/2020
CHEM3061 Chemistry of Materials
UNSW
Lecturer 1/1/2019 - 31/12/2020
CHEM3550 Medicinal and Biological Chemistry
Discipline of Chemistry, University of Newcastle
Lecturer 1/7/2020 - 31/12/2020
NANO1001 Introduction to Nanomaterials
UNSW
Lecturer 1/1/2017 - 31/12/2018
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (45 outputs)

Year Citation Altmetrics Link
2021 Wang Y, Milewska M, Foster H, Chapman R, Stenzel MH, 'The Core-Shell Structure, Not Sugar, Drives the Thermal Stabilization of Single-Enzyme Nanoparticles.', Biomacromolecules, (2021)
DOI 10.1021/acs.biomac.1c00871
2020 Massi L, Najer A, Chapman R, Spicer CD, Nele V, Che J, et al., 'Tuneable peptide cross-linked nanogels for enzyme-triggered protein delivery', Journal of Materials Chemistry B, 8 8894-8907 (2020)

Many diseases are associated with the dysregulated activity of enzymes, such as matrix metalloproteinases (MMPs). This dysregulation can be leveraged in drug delivery to achieve d... [more]

Many diseases are associated with the dysregulated activity of enzymes, such as matrix metalloproteinases (MMPs). This dysregulation can be leveraged in drug delivery to achieve disease- or site-specific cargo release. Self-assembled polymeric nanoparticles are versatile drug carrier materials due to the accessible diversity of polymer chemistry. However, efficient loading of sensitive cargo, such as proteins, and introducing functional enzyme-responsive behaviour remain challenging. Herein, peptide-crosslinked, temperature-sensitive nanogels for protein delivery were designed to respond to MMP-7, which is overexpressed in many pathologies including cancer and inflammatory diseases. The incorporation ofN-cyclopropylacrylamide (NCPAM) intoN-isopropylacrylamide (NIPAM)-based copolymers enabled us to tune the polymer lower critical solution temperature from 33 to 44 °C, allowing the encapsulation of protein cargo and nanogel-crosslinking at slightly elevated temperatures. This approach resulted in nanogels that were held together by MMP-sensitive peptides for enzyme-specific protein delivery. We employed a combination of cryogenic transmission electron microscopy (cryo-TEM), dynamic light scattering (DLS), small angle neutron scattering (SANS), and fluorescence correlation spectroscopy (FCS) to precisely decipher the morphology, self-assembly mechanism, enzyme-responsiveness, and model protein loading/release properties of our nanogel platform. Simple variation of the peptide linker sequence and combining multiple different crosslinkers will enable us to adjust our platform to target specific diseases in the future.

DOI 10.1039/d0tb01546f
Citations Scopus - 4
2020 Wang Y, Cheng YT, Cao C, Oliver JD, Stenzel MH, Chapman R, 'Polyion Complex-Templated Synthesis of Cross-Linked Single-Enzyme Nanoparticles', MACROMOLECULES, 53 5487-5496 (2020)
DOI 10.1021/acs.macromol.0c00528
Citations Scopus - 3Web of Science - 3
2020 Li Z, Ganda S, Melodia D, Boyer C, Chapman R, 'Well-Defined Polymers for Nonchemistry Laboratories using Oxygen Tolerant Controlled Radical Polymerization', JOURNAL OF CHEMICAL EDUCATION, 97 549-556 (2020)
DOI 10.1021/acs.jchemed.9b00922
Citations Scopus - 5Web of Science - 5
2020 Farazi S, Chen F, Foster H, Boquiren R, McAlpine SR, Chapman R, 'Real time monitoring of peptide delivery in vitro using high payload pH responsive nanogels', POLYMER CHEMISTRY, 11 425-432 (2020)
DOI 10.1039/c9py01120j
Citations Scopus - 7Web of Science - 6
2020 Li K, Chen F, Wang Y, Stenzel MH, Chapman R, 'Polyion Complex Micelles for Protein Delivery Benefit from Flexible Hydrophobic Spacers in the Binding Group', Macromolecular Rapid Communications, 41 (2020)

Although a range of polymer¿protein polyion complex (PIC) micelle systems have been developed in the literature, relatively little attention has been paid to the influence of poly... [more]

Although a range of polymer¿protein polyion complex (PIC) micelle systems have been developed in the literature, relatively little attention has been paid to the influence of polymer structure on the assembly, or to the mechanism of disassembly. In this work, Förster resonance energy transfer is used in combination with light sheet fluorescence microscopy and isothermal calorimetry to monitor the formation and stability of PIC micelles with various carboxylic-acid-based binding blocks in MCF-7 cancer spheroid models. All micelles are stable in the presence of free protein, but are unstable in solutions with an ionic strength >200 mm and prone to disassembly at reduced pH. Introducing carbon spacers between the backbone and the binding carboxylic acid results in improved PIC micelle stability at physiological pH, but also increases the pKa of the binding moiety, resulting in improved protein release upon cell uptake. These results give important insights into how to tune PIC micelle stability for controlled protein release in biological environments.

DOI 10.1002/marc.202000208
Citations Scopus - 6
2020 Zheng P, Zhang X, Duan Y, Yan M, Chapman R, Jiang Y, Li H, 'Oxidation of graphene with variable defects: alternately symmetrical escape and self-restructuring of carbon rings', Nanoscale, 12 10140-10148 (2020)

Variable defects such as vacancies and grain boundaries are unavoidable in the synthesis of graphene, but play a central role in the activation of oxidation. Here, we apply reacti... [more]

Variable defects such as vacancies and grain boundaries are unavoidable in the synthesis of graphene, but play a central role in the activation of oxidation. Here, we apply reactive molecular dynamics simulations to reveal the underpinning mechanisms of oxidation in graphene with or without defects at the atomic scale. There exist four oxidation modes generating CO2 or CO in different stages, beginning from a single-atom vacancy, and proceeding until the ordered structure broken down into carbon oxide chains. The oxidation process of the graphene sheets experiences four typical stages, in which alternately symmetrical escape phenomenon is observed. Importantly, disordered rings can self-restructure during the oxidation of grain boundaries. Of all defects, the oxidation of vacancy has the lowest energy barrier and is therefore the easiest point of nucleation. This study demonstrates the crucial role of defects in determining the oxidation kinetics, and provides theoretical guidance for the oxidation prevention of graphene and the production of functionalized graphene.

DOI 10.1039/c9nr10613h
Citations Scopus - 4
2019 Chapman R, Stenzel MH, 'All Wrapped up: Stabilization of Enzymes within Single Enzyme Nanoparticles', JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 141 2754-2769 (2019)
DOI 10.1021/jacs.8b10338
Citations Scopus - 58Web of Science - 58
2019 Li Z, Kosuri S, Foster H, Cohen J, Jumeaux C, Stevens MM, et al., 'A Dual Wavelength Polymerization and Bioconjugation Strategy for High Throughput Synthesis of Multivalent Ligands', JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 141 19823-19830 (2019)
DOI 10.1021/jacs.9b09899
Citations Scopus - 6Web of Science - 8
2019 Oliver S, Zhao L, Gormley AJ, Chapman R, Boyer C, 'Living in the Fast Lane High Throughput Controlled/Living Radical Polymerization', MACROMOLECULES, 52 3-23 (2019)
DOI 10.1021/acs.macromol.8b01864
Citations Scopus - 39Web of Science - 37
2019 Rahimi MN, Foster HG, Farazi SN, Chapman R, McAlpine SR, 'Polymer mediated transport of the Hsp90 inhibitor LB76, a polar cyclic peptide, produces an Hsp90 cellular phenotype', CHEMICAL COMMUNICATIONS, 55 4515-4518 (2019)
DOI 10.1039/c9cc00890j
Citations Scopus - 4Web of Science - 3
2019 Chen F, Raveendran R, Cao C, Chapman R, Stenzel MH, 'Correlation between polymer architecture and polyion complex micelle stability with proteins in spheroid cancer models as seen by light- sheet microscopy', POLYMER CHEMISTRY, 10 1221-1230 (2019)
DOI 10.1039/c8py01565a
Citations Scopus - 6Web of Science - 6
2018 Gormley AJ, Yeow J, Ng G, Conway Ó, Boyer C, Chapman R, 'An Oxygen-Tolerant PET-RAFT Polymerization for Screening Structure Activity Relationships', Angewandte Chemie, 130 1573-1578 (2018)
DOI 10.1002/ange.201711044
2018 Yeow J, Joshi S, Chapman R, Boyer C, 'A Self-Reporting Photocatalyst for Online Fluorescence Monitoring of High Throughput RAFT Polymerization', Angewandte Chemie, 130 10259-10263 (2018)
DOI 10.1002/ange.201802992
2018 Ishizuka F, Chapman R, Kuche RP, Coureault M, Zetterlund PB, Stenzel MH, 'Polymeric Nanocapsules for Enzyme Stabilization in Organic Solvents', MACROMOLECULES, 51 438-446 (2018)
DOI 10.1021/acs.macromol.7b02377
Citations Scopus - 22Web of Science - 18
2018 Ng G, Yeow J, Chapman R, Isahak N, Wolyetang E, Cooper-White JJ, Boyer C, 'Pushing the Limits of High Throughput PET-RAFT Polymerization', MACROMOLECULES, 51 7600-7607 (2018)
DOI 10.1021/acs.macromol.8b01600
Citations Scopus - 45Web of Science - 42
2018 Yeow J, Chapman R, Gormley AJ, Boyer C, 'Up in the air: oxygen tolerance in controlled/living radical polymerisation', CHEMICAL SOCIETY REVIEWS, 47 4357-4387 (2018)
DOI 10.1039/c7cs00587c
Citations Scopus - 173Web of Science - 166
2018 Gormley AJ, Yeow J, Ng G, Conway O, Boyer C, Chapman R, 'An Oxygen-Tolerant PET-RAFT Polymerization for Screening Structure-Activity Relationships', ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 57 1557-1562 (2018)
DOI 10.1002/anie.201711044
Citations Scopus - 100Web of Science - 97
2018 Yeow J, Joshi S, Chapman R, Boyer C, 'A Self-Reporting Photocatalyst for Online Fluorescence Monitoring of High Throughput RAFT Polymerization', ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 57 10102-10106 (2018)
DOI 10.1002/anie.201802992
Citations Scopus - 34Web of Science - 29
2018 Milner PE, Parkes M, Puetzer JL, Chapman R, Stevens MM, Cann P, Jeffers JRT, 'A low friction, biphasic and boundary lubricating hydrogel for cartilage replacement', ACTA BIOMATERIALIA, 65 102-111 (2018)
DOI 10.1016/j.actbio.2017.11.002
Citations Scopus - 40Web of Science - 38
2017 Yeow J, Chapman R, Xu J, Boyer C, 'Oxygen tolerant photopolymerization for ultralow volumes', POLYMER CHEMISTRY, 8 5012-5022 (2017)
DOI 10.1039/c7py00007c
Citations Scopus - 133Web of Science - 128
2017 Chapman R, Melodia D, Qu J-B, Stenzel MH, 'Controlled poly(olefin)s via decarboxylation of poly(acrylic acid)', POLYMER CHEMISTRY, 8 6636-6643 (2017)
DOI 10.1039/c7py01466j
Citations Scopus - 4Web of Science - 4
2017 Qu J-B, Chapman R, Chen F, Lu H, Stenzel MH, 'Swollen Micelles for the Preparation of Gated, Squeezable, pH Responsive Drug Carriers', ACS APPLIED MATERIALS & INTERFACES, 9 13865-13874 (2017)
DOI 10.1021/acsami.7b01120
Citations Scopus - 21Web of Science - 21
2016 Chapman R, Gormley AJ, Stenzel MH, Stevens MM, 'Combinatorial Low-Volume Synthesis of Well-Defined Polymers by Enzyme Degassing', ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 55 4500-4503 (2016)
DOI 10.1002/anie.201600112
Citations Scopus - 81Web of Science - 73
2016 Liu NJ, Chapman R, Lin Y, Mmesi J, Bentham A, Tyreman M, et al., 'Point of care testing of phospholipase A2 group IIA for serological diagnosis of rheumatoid arthritis', NANOSCALE, 8 4482-4485 (2016)
DOI 10.1039/c5nr08423g
Citations Scopus - 15Web of Science - 13
2016 Liu NJ, Chapman R, Lin Y, Bentham A, Tyreman M, Philips N, et al., 'Phospholipase A2 as a point of care alternative to serum amylase and pancreatic lipase', NANOSCALE, 8 11834-11839 (2016)
DOI 10.1039/c6nr03376h
Citations Scopus - 4Web of Science - 4
2015 Lin Y, Chapman R, Stevens MM, 'Integrative Self-Assembly of Graphene Quantum Dots and Biopolymers into a Versatile Biosensing Toolkit', ADVANCED FUNCTIONAL MATERIALS, 25 3183-3192 (2015)
DOI 10.1002/adfm.201500624
Citations Scopus - 46Web of Science - 42
2015 Harrison RH, Steele JAM, Chapman R, Gormley AJ, Chow LW, Mahat MM, et al., 'Modular and Versatile Spatial Functionalization of Tissue Engineering Scaffolds through Fiber-Initiated Controlled Radical Polymerization', ADVANCED FUNCTIONAL MATERIALS, 25 5748-5757 (2015)
DOI 10.1002/adfm.201501277
Citations Scopus - 30Web of Science - 30
2015 Jumeaux C, Chapman R, Chandrawati R, Stevens MM, 'Synthesis and self-assembly of temperature-responsive copolymers based on N-vinylpyrrolidone and triethylene glycol methacrylate', POLYMER CHEMISTRY, 6 4116-4122 (2015)
DOI 10.1039/c5py00483g
Citations Scopus - 9Web of Science - 9
2015 Chapman R, Lin Y, Burnapp M, Bentham A, Hillier D, Zabron A, et al., 'Multivalent Nanoparticle Networks Enable Point-of-Care Detection of Human Phospholipase-A2 in Serum', ACS NANO, 9 2565-2573 (2015)
DOI 10.1021/nn5057595
Citations Scopus - 77Web of Science - 76
2014 Lin Y, Chapman R, Stevens MM, 'Label-Free Multimodal Protease Detection Based on Protein/Perylene Dye Coassembly and Enzyme-Triggered Disassembly', ANALYTICAL CHEMISTRY, 86 6410-6417 (2014)
DOI 10.1021/ac500777r
Citations Scopus - 29Web of Science - 28
2014 Chapman R, Gormley AJ, Herpoldt K-L, Stevens MM, 'Highly Controlled Open Vessel RAFT Polymerizations by Enzyme Degassing', MACROMOLECULES, 47 8541-8547 (2014)
DOI 10.1021/ma5021209
Citations Scopus - 119Web of Science - 117
2014 Blunden BM, Chapman R, Danial M, Lu H, Jolliffe KA, Perrier S, Stenzel MH, 'Drug Conjugation to Cyclic Peptide-Polymer Self-Assembling Nanotubes', CHEMISTRY-A EUROPEAN JOURNAL, 20 12745-12749 (2014)
DOI 10.1002/chem.201403130
Citations Scopus - 32Web of Science - 32
2014 Gormley AJ, Chapman R, Stevens MM, 'Polymerization Amplified Detection for Nanoparticle-Based Biosensing', NANO LETTERS, 14 6368-6373 (2014)
DOI 10.1021/nl502840h
Citations Scopus - 42Web of Science - 43
2013 Chapman R, Jolliffe KA, Perrier S, 'Multi-shell Soft Nanotubes from Cyclic Peptide Templates', ADVANCED MATERIALS, 25 1170-1172 (2013)
DOI 10.1002/adma.201204094
Citations Scopus - 34Web of Science - 35
2013 Chapman R, Warr GG, Perrier S, Jolliffe KA, 'Water-Soluble and pH-Responsive Polymeric Nanotubes from Cyclic Peptide Templates', CHEMISTRY-A EUROPEAN JOURNAL, 19 1955-1961 (2013)
DOI 10.1002/chem.201203602
Citations Scopus - 33Web of Science - 32
2013 Chapman R, Bouten PJM, Hoogenboom R, Jolliffe KA, Perrier S, 'Thermoresponsive cyclic peptide - poly(2-ethyl-2-oxazoline) conjugate nanotubes', CHEMICAL COMMUNICATIONS, 49 6522-6524 (2013)
DOI 10.1039/c3cc42327a
Citations Scopus - 32Web of Science - 31
2013 Chapman R, Koh ML, Warr GG, Jolliffe KA, Perrier S, 'Structure elucidation and control of cyclic peptide-derived nanotube assemblies in solution', CHEMICAL SCIENCE, 4 2581-2589 (2013)
DOI 10.1039/c3sc00064h
Citations Scopus - 41Web of Science - 40
2012 Chapman R, Danial M, Koh ML, Jolliffe KA, Perrier S, 'Design and properties of functional nanotubes from the self-assembly of cyclic peptide templates', CHEMICAL SOCIETY REVIEWS, 41 6023-6041 (2012)
DOI 10.1039/c2cs35172b
Citations Scopus - 206Web of Science - 202
2012 Wilkinson BL, Day S, Chapman R, Perrier S, Apostolopoulos V, Payne RJ, 'Synthesis and Immunological Evaluation of Self-Assembling and Self-Adjuvanting Tricomponent Glycopeptide Cancer-Vaccine Candidates', CHEMISTRY-A EUROPEAN JOURNAL, 18 16540-16548 (2012)
DOI 10.1002/chem.201202629
Citations Scopus - 44Web of Science - 44
2012 Junkers T, Delaittre G, Chapman R, Guenzler F, Chernikova E, Barner-Kowollik C, 'Thioketone-Mediated Polymerization with Dithiobenzoates: Proof for the Existence of Stable Radical Intermediates in RAFT Polymerization', MACROMOLECULAR RAPID COMMUNICATIONS, 33 984-990 (2012)
DOI 10.1002/marc.201200128
Citations Scopus - 18Web of Science - 18
2012 Poon CK, Chapman R, Jolliffe KA, Perrier S, 'Pushing the limits of copper mediated azide-alkyne cycloaddition (CuAAC) to conjugate polymeric chains to cyclic peptides', POLYMER CHEMISTRY, 3 1820-1826 (2012)
DOI 10.1039/c2py00510g
Citations Scopus - 30Web of Science - 29
2011 Dehn S, Chapman R, Jolliffe KA, Perrier S, 'Synthetic Strategies for the Design of Peptide/Polymer Conjugates', POLYMER REVIEWS, 51 214-234 (2011)
DOI 10.1080/15583724.2011.566404
Citations Scopus - 69Web of Science - 70
2011 Chapman R, Jolliffe KA, Perrier S, 'Modular design for the controlled production of polymeric nanotubes from polymer/peptide conjugates', POLYMER CHEMISTRY, 2 1956-1963 (2011)
DOI 10.1039/c1py00202c
Citations Scopus - 65Web of Science - 67
2010 Chapman R, Jolliffe KA, Perrier S, 'Synthesis of Self-assembling Cyclic Peptide-polymer Conjugates using Click Chemistry', AUSTRALIAN JOURNAL OF CHEMISTRY, 63 1169-1172 (2010)
DOI 10.1071/CH10128
Citations Scopus - 45Web of Science - 46
Show 42 more journal articles

Conference (3 outputs)

Year Citation Altmetrics Link
2015 Harrison RH, Chapman R, Gormley AJ, Chow LW, Steele JA, Mahat M, et al., 'Free Radical Polymerization for the Controlled and Facile Production of a Cell Repellent and Antifouling Surface in 2-and 3D Systems', TISSUE ENGINEERING PART A, Boston, MA (2015)
2011 Chapman R, Poon CK, Jolliffe KA, Perrier S, 'Polymeric nanotubes using a convergent approach with RAFT polymerisation', ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Denver, CO (2011)
2011 Chapman R, Jolliffe KA, Perrier S, 'Peptide directed self assembly of polymeric nanotubes', ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Denver, CO (2011)
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Grants and Funding

Summary

Number of grants 7
Total funding $1,264,500

Click on a grant title below to expand the full details for that specific grant.


20211 grants / $30,000

Novel polymers for NOM removal and waste water treatment$30,000

Funding body: Sydney Water Corporation

Funding body Sydney Water Corporation
Project Team Doctor Robert Chapman, Dr Heriberto Bustamante
Scheme Research Project
Role Lead
Funding Start 2021
Funding Finish 2021
GNo G2100430
Type Of Funding C3100 – Aust For Profit
Category 3100
UON Y

20201 grants / $7,000

Synthetic protein mimics to control cell behaviour through receptor clustering$7,000

Funding body: Faculty of Science | University of Newcastle

Funding body Faculty of Science | University of Newcastle
Project Team

Robert Chapman

Scheme Fellowship Accelerator
Role Lead
Funding Start 2020
Funding Finish 2020
GNo
Type Of Funding Internal
Category INTE
UON N

20191 grants / $25,000

Creating a molecular switch that controls cell stress via heat shock protein 27 (Hsp27)$25,000

Funding body: UNSW

Funding body UNSW
Project Team

Shelli McAlpine, Robert Chapman

Scheme Faculty Research Grant
Role Investigator
Funding Start 2019
Funding Finish 2019
GNo
Type Of Funding Internal
Category INTE
UON N

20172 grants / $693,500

Combinatorial design of multivalent polymers for cell receptor clustering$360,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team

Robert Chapman

Scheme ARC DECRA
Role Lead
Funding Start 2017
Funding Finish 2019
GNo
Type Of Funding C1200 - Aust Competitive - ARC
Category 1200
UON N

Polymeric nanoparticles for enzyme stabilisation$333,500


Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team

Martina Stenzel, Robert Chapman

Scheme ARC Discovery
Role Investigator
Funding Start 2017
Funding Finish 2019
GNo
Type Of Funding C1200 - Aust Competitive - ARC
Category 1200
UON N

20161 grants / $403,000

Macromolecular therapeutics by combinatorial polymer design$403,000

Funding body: UNSW

Funding body UNSW
Project Team

Robert Chapman

Scheme Vice-Chancellors Postdoctoral Fellowships
Role Lead
Funding Start 2016
Funding Finish 2018
GNo
Type Of Funding External
Category EXTE
UON N

20151 grants / $106,000

Rapid diagnosis of sepsis at point of care using liposomes to amplify PLA2G2A activity in a lateral flow device$106,000

Funding body: MRC Medical Research Council UK

Funding body MRC Medical Research Council UK
Project Team

Molly Stevens, Anthony Gordon, Robert Chapman

Scheme Confidence in concept
Role Investigator
Funding Start 2015
Funding Finish 2016
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N
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Research Supervision

Number of supervisions

Completed5
Current8

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2022 PhD Polymer-Peptide Conjugates for Controlling Cell Rate through Receptor Clustering PhD (Chemistry), College of Engineering, Science and Environment, The University of Newcastle Principal Supervisor
2020 PhD High throughput synthesis of single chain polymer nanoparticles Chemical Sciences, UNSW Co-Supervisor
2020 PhD Peptide driven folding of single chain polymer nanoparticles Chemical Sciences, UNSW Co-Supervisor
2019 PhD Drug delivery of Hsp70 regulators using polymeric nanogels Chemical Sciences, UNSW Co-Supervisor
2018 PhD Multivalent peptide-polymer therapeutics by combinatorial design Organic Chemistry, UNSW Principal Supervisor
2018 PhD Delivery of antibodies across the blood brain barrier for the treatment of Alzheimer's disease Chemical Sciences, UNSW Co-Supervisor
2017 PhD Single enzyme nanogels for enhanced biocatalyst activity and stability Chemical Sciences, UNSW Co-Supervisor
2017 PhD Design of polymers for protein binding using high throughput techniques Chemical Sciences, UNSW Co-Supervisor

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2020 Honours Nucleobase polymers for the preparation of complex nanostructures Chemical Sciences, UNSW Sole Supervisor
2020 Honours The combinatorial synthesis of multivalent peptide-polymer conjugates for extracellular death-receptor clustering Chemical Sciences, UNSW Principal Supervisor
2019 Honours Real time monitoring of peptide delivery in vitro using high payload pH responsive nanogels Chemical Sciences, UNSW Principal Supervisor
2019 Honours Peptides as guiding motifs for the directed folding of single chain nanoparticles Chemical Sciences, UNSW Principal Supervisor
2017 Honours Enzyme stabilisation by encapsulation within glycopolymer nanoparticles Chemical Sciences, UNSW Principal Supervisor
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Dr Robert Chapman

Position

Lecturer
School of Environmental and Life Sciences
College of Engineering, Science and Environment

Contact Details

Email robert.chapman@newcastle.edu.au
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