The University of Newcastle, Australia
Available in 2020

Course handbook

Description

This course is subdivided into 3 chemistry areas: analytical, medicinal and organic, focusing on their relevance to pharmaceutical science. Students are provided an introduction to the fundamental instrumental methods of chemical analysis commonly used in pharmaceutical laboratories (e.g. UV-Vis spectrophotometry, atomic absorption spectroscopy) and basic separation and purification techniques including chromatography and electrophoresis.

This course also deals with functional group chemistry and their roles in drugs. Students are also introduced to medicinal chemistry, which is designed to examine chemistry at the interface between the chemical and biological sciences. The basic principles of synthetic and structural chemistry are applied to examination of the synthesis of biologically active molecules and drugs, and the structure, activity and interaction of biomolecules, including metalloproteins and natural products.

The main spectroscopic techniques - infrared, nuclear magnetic resonance, and mass spectrometry, for the characterisation of functional groups and pharmaceutical compounds, are taught in the form of workshops.

The laboratory introduces the students to practical skills on the synthesis, separation, purification and quantitation of pharmaceutical and other relevant compounds.


Availability2020 Course Timetables

Callaghan

  • Semester 2 - 2020

Learning outcomes

On successful completion of the course students will be able to:

1. Describe and compare analytical methods for the separation and identification of pharmaceutical and other biologically active compounds;

2. Identify and differentiate between organic compound functional groups used in drug design and development;

3. Apply spectroscopic techniques in the identification of functional groups and elucidation of the structure of pharmaceutical compounds;

4. Explain approaches used to develop new drugs either from natural sources or by rational drug design;

5. Independently integrate key concepts in organic, medicinal and organic chemistry as applied to pharmaceutical science;

6. Work safely and competently in a chemical laboratory;

7. Contribute to team and group work for scientific investigation and reporting.


Content

1. Molecular Spectrophotometry

2. Atomic Spectroscopy: Atomic absorption & Flame emission spectroscopy                             

3. Chromatography: Principles, Gas & Liquid chromatography

4. Electrophoresis

5. Structure determination & characterisation of organic compounds: infrared & nuclear magnetic resonance spectroscopy, mass spectrometry

6. Molecular Structure: Stereochemistry

7. The Role of Functional Groups in Drugs                                

8. Natural Compounds: Isolation & applications

9. Medicinal Compounds:The range & role of synthetic molecules in medicine, approaches to the rational design & development of new drugs.


Requisite

Pre-requisite - successful completion of CHEM1010 and CHEM1020


Assessment items

Formal Examination: Written Exam *

Tutorial / Laboratory Exercises: Laboratory attendance/Laboratory reports *

Tutorial / Laboratory Exercises: Spectroscopy Assessment *

* This assessment has a compulsory requirement.


Compulsory Requirements

In order to pass this course, each student must complete ALL of the following compulsory requirements:

General Course Requirements:

  • Laboratory: There is a compulsory attendance requirement in this course. - Students may only miss 1 laboratory session.
  • Laboratory: Induction Requirement - Students must attend and pass the induction requirements before attending these sessions.

Course Assessment Requirements:

  • Tutorial / Laboratory Exercises: Pass Requirement - Students must pass this assessment item to pass the course. - Students must obtain a minimum passing grade of 50%.
  • Tutorial / Laboratory Exercises: Pass Requirement - Students must pass this assessment item to pass the course. - Students must obtain a passing grade of at least 50%.
  • Formal Examination: Minimum Grade / Mark Requirement - Students must obtain a specified minimum grade / mark in this assessment item to pass the course. - Students must obtain a minimum passing grade of 40%.

Contact hours

Callaghan

Laboratory

Face to Face On Campus 3 hour(s) per Week for 8 Weeks

Lectorial

Face to Face On Campus 3 day(s) per Week for 12 Weeks

Workshop

Face to Face On Campus 3 hour(s) per Week for 4 Weeks