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Laureate Professor Paul Foster

Laureate Professor

School of Biomedical Sciences and Pharmacy (Immunology and Microbiology)

Respiratory respite

Acutely aware of the burden presented by progressive and disabling chronic airway conditions, Laureate Professor Paul Foster is working to cement a universal, scientific understanding of breathing's pathological spinoff – breathlessness.

Paul Foster

Laureate Professor Paul Foster is a leader and a visionary keen on making life easier for patients suffering from respiratory disorders. As Director, he coordinates investigative efforts for a variety of prominent, preclinical research groups in the Hunter, seeking to solidify links between disease state, infections, inflammation and immune responses.

"Our focus is on identifying the molecular and cellular pathways that cause these conditions," he explains.

"It's a really fundamental approach – we're looking at the hows and whys at a cellular level."

"For example, we've established several transgenic mouse models to gain insights into new approaches to diagnosis and treatment."

Paul is the Director of the University of Newcastle's Priority Research Centre for Asthma and Respiratory Diseases, the Director of VIVA (Vaccines, Immunology, Viruses and Asthma) at the Hunter Medical Research Institute, and the University's Chair in Immunology. He also teaches into the second and third-year immunology programs in the School of Biomedical Sciences and Pharmacy.

"I'm not physically involved in experimentation anymore," he concedes.

"I hold group meetings to help analyse the data that comes in on specific projects."

"It's nice to be able to contribute to the generation of knowledge that underpins really important work."

"Our aim is to unravel the complexities of the pathophysiology of various chronic airway diseases."

Further afield, Paul has contributed significantly to the global advancement of respiratory medicine, bringing together clinical, applied, epidemiological and basic science research to examine problems associated with asthma, emphysema and respiratory infections. His Centres' discoveries, made by senior scientists, postdoctoral fellows, PhD candidates and eager undergraduates, have similarly informed the development of new therapeutic strategies and the translation of basic work to clinical outcomes.

All muscle

Paul began his research career with a first class Honours Degree in pharmacology and biochemistry from the University of Western Australia. Looking at smooth muscle functioning in asthma, he sought to understand the role of this cell in asthma.

"Smooth muscle lines the walls of blood vessels and our airways, and controls the diameter of these structures," Paul states.

"In asthma airway, smooth muscle constricts and narrows the breathing tube, leading to limitation in airflow."

"We showed that steroids increase the effectiveness of smooth muscle relaxation."

Awarded a Commonwealth Scholarship after receiving his Honours Degree in 1983, he moved across the country to undertake a PhD at the Australian National University's John Curtin School of Medical Research. Exploring the biochemical basis of the skeletal muscle disorder known as malignant hyperpyrexia during the four-years of investigation, Paul described a number of molecular defects that predispose to this often-fatal illness, which is triggered by general anaesthesia.

"Calcium regulation is abnormal within the muscle cells and this mechanism is very sensitive to general anaesthetics," he clarifies.

"When an anaesthetic hits the muscle, it causes a release of lots of calcium and a series of uncontrollable rigor contractions, which make the body very hot."

"Malignant hyperpyrexia is a skeletal muscle abnormality which when triggered, leads to loss of core metabolic control and cardiac arrest."

Paul continued to study the development of this disease post-PhD, staying on at the prestigious medical school to accept several postdoctoral fellowships. Related to a burgeoning interest in calcium movement within airway cells and muscle cells, the extension widened the research scope of a once "very specific and narrow" muscle biochemistry field.

"John Curtin also offered me a professorial position," he discloses.

"The place produced two Nobel Prize winners and was research intensive, so it was exciting to be there."

Life and breath

Paul found a new avenue of investigation once the molecular defects in malignant hyperpyrexia were found and "fully characterised," opting to return to his primary interest in asthma in the late 1990s.

"We started to examine inflammation, which is the abnormal accumulation of white blood cells in the lung that drives asthmatic responses and other lung conditions," he states.

"I was still very interested in that area of research."

Paul then moved to the University of Newcastle in 2002, establishing the Priority Research Centre for Asthma and Respiratory Diseases. Internationally recognised for its talented clinician scientists and doctors, as well as an extensive publication catalogue, the Centre is a national training hub for respiratory medicine and immunology.

"We work on understanding how chronic airway conditions progress," he declares.

"We also look closely at the role of infection in driving pathogenesis."

Fundamental and experimental

Current research in Paul's laboratory is aimed at defining the cellular and molecular processes that underlie the development of allergic disease and viral-induced pulmonary inflammation. Another major objective is to gather a concrete understanding of the role of non-coding RNA in the regulation of blood cell development.

"Messenger RNAs produce proteins," he discloses.

"Non-coding RNAs, however, don't code for proteins, and their function is just beginning to be understood."

"We know they can regulate transcriptional networks within cells and therefore profoundly affect the functioning of organs."

"We're trying to figure out why microRNA and non-coding RNA are important in asthma as this will hopefully allow us to identify and create new therapeutic targets."

Paul and his team are simultaneously exploring the role of T-lymphocytes in the onset and progression of several lung disorders.

"These are small cells that can be activated in a very specific manner by specific antigens," he reveals.

"When they are activated appropriately, their job is to kill infectious agents."

"When they are actively inappropriately, they damage tissue and this over time leads to chronic disease."

Pointing to the latter as an all-too-common occurrence in the cells of patients with asthma and emphysema, Paul is seeking to make sense of a complicated disease process. He's breaking T-lymphocytes down into subsets for further study, hoping to harness knowledge about their individual roles in allergic responses and inflammatory conditions of the lung.

"We're really interested in the T-helper 2 subset," Paul shares.

"We also recently described the role of generation of a new T-helper 22 subset."

"We now know how to generate that cell that will allow its characterisation."

At the same time, the respiratory researcher is supervising PhD students working on models of severe asthma.

"This particular condition is very difficult to treat," he acknowledges.

"You get given steroids and bronchodilators but often in these patients they're not very effective – and no one knows why."

"Infection also plays a critical role triggering acute exacerbations of asthma."

Paul's team is developing a number of experimental mouse models to investigate, and manipulate, the hallmark features of asthma and other respiratory diseases, and they are looking to classify its key pathogenic events and explore the role of associated infections in disease processes.

From the bench to the bedside

Paul is a fan of collaborative thinking both in and out of the laboratory. He is also a firm believer in the power of translational research.

"What all of us want to see is a better outcome for patients," the research leader says.

"New treatment options would be great and that is our goal."

More about Paul's Career

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Paul Foster

Respiratory respite

Acutely aware of the burden presented by progressive and disabling chronic airway conditions, Laureate Professor Paul Foster is working to cement a universal, s

Read more

Joining forces to ease the wheeze

Australia's two million sufferers of airway disease can breathe easier thanks to the work of the University's groundbreaking respiratory researchers.

Laureate Professor Paul FosterFrom the bench to the bedside, the University of Newcastle's Priority Research Centre for Asthma and Respiratory Diseases is leading the way in the understanding, management and treatment of chronic airway conditions.

Centre co-directors Laureate Professor Paul Foster and Professor Peter Gibson lead highly talented teams of scientists and doctors who integrate the latest advances in laboratory technology and methodology with innovative, patient-focused research.

The work of the Centre is internationally recognised, having contributed significantly to advancing both medical practice and policy through its discoveries.

Its studies are regularly published in the most prestigious journals and it is a major training hub for respiratory medicine and immunology, attracting gifted PhD students and postdoctoral researchers from around the world to work and study in Newcastle.

Foster and Gibson's teams work under the umbrella of the Hunter Medical Research Institute (HMRI), a partnership between the University of Newcastle and Hunter New England Health. They also collaborate with research groups in Sydney, Newcastle, Melbourne and Perth as part of the Cooperative Research Centre for Asthma and Airways, a $55 million government-backed program.

Gibson is working at the clinical interface, using his role as a respiratory physician at the John Hunter Hospital in Newcastle to inform his research into treatments and management strategies for asthma and airway disease.

Foster, the University's Chair in Immunology, investigates the molecular and cellular mechanisms of disease in the laboratory. Both have a keen interest in unravelling the critical role of inflammation in asthma and other respiratory conditions.

"We are constantly on the lookout for better treatments but with a disease like asthma, management is also important," Gibson says.

"For some people, just understanding what is happening to them is enough to make a big difference to their condition and quality of life."

Gibson's clinically based team is involved in research projects with significant implications for future treatment and management of airway disease (see below).

Novel discoveries have also been made by the centre's laboratory-based researchers.  These discoveries have enhanced the understanding of processes associated with the development and progression of respiratory diseases.

Centre scientists study the cellular and molecular functions of the diseases on animal models then collaborate with the clinical researchers to validate their findings using human tissue.

Foster says the centre is at the forefront of interpreting how inflammation, which underpins airway disease, occurs and of developing new anti-inflammatory treatments.

A major breakthrough was their research into how microRNA molecules, which regulate protein production in human cells, can cause inflammation in the body that can manifest as asthma. Working out how to control that inflammatory response has provided scientists with a therapeutic target, which could lead to new treatments.

"Steroids are the conventional treatment, but they can have side effects and while they dampen response, they do not cure the disease," Foster explains.

"Also, not everyone is responsive to steroids and within that non-responsive group there is a lot of morbidity."

Foster says his team has made a significant contribution to the understanding of the mechanisms of steroid-resistant inflammatory pathways that may be relevant to asthma, bringing them closer to the goal of developing alternative treatments. Other critical areas of laboratory research focus on allergies, viruses and infection as triggers for asthma.

While the two arms of research within the centre are undertaken by different teams, Foster says it is the critical mass that contributes to its overall success.

"What we have is diversity and common interest," he says. "There are similar centres of excellence around the world but they primarily do either clinical-based research or basic immunology. The way the two are integrated here is what makes us unique and underpins our success."

"People are willing to collaborate," Gibson agrees, "and it is only by linking patient-focused research with laboratory discoveries and evidence-based medicine that we are able to get these broad insights into disease."

Leading the wayProfessor Paul Foster and Professor Peter Gibson talking

Professor Peter Gibson's clinical research team is leading three groundbreaking projects that could revolutionise the treatment of asthma.

These specific projects involve better management of asthma in pregnancy, the development of a blood test to diagnose the disease and the treatment of non-eosinophilic asthma with macrolide antibiotics.

The team's study into asthma in pregnancy was prompted by the reluctance of women to use treatments during gestation, even though severe asthmatic episodes can be harmful to both mother and child.

As part of this project, researchers measured nitric oxide, which is produced by inflamed airways, in the pregnant patient's exhaled breath. They were then able to adjust the amount of medication according to the severity of the inflammation.

In many cases this reduced the amount of steroid that needed to be administered, which made women more likely to take their medication as they were less apprehensive about the treatment and its effects on their unborn child.

Another benefit was that the frequency of asthma exacerbations, or episodes, decreased because the condition was being better managed.

In another study, published this year in the American Journal of Respiratory and Critical Care Medicine, the team used the emerging scientific field of proteomics (the study of proteins) to identify four blood-based biomarkers that when analysed together can distinguish between asthma and chronic obstructive pulmonary disease.

The two diseases share common symptoms, so are difficult to distinguish, but require different therapeutic approaches.

This finding could lead to the development of the first blood test for asthma, which would be a major diagnostic breakthrough.

The third project is the AMAZES study (Asthma and Macrolides: Azithromycin Efficacy and Safety). It will trial an alternative treatment, known as a macrolide antibiotic, for asthma that is not responsive to conventional steroid medication.

Steroids treat a particular cell, called an eosinophil, which is thought to provoke inflammation when present in increased levels. But research has established that up to half of adults with asthma symptoms have normal levels of eosinophils and respond poorly to conventional treatment.

The five-year, $2.9 million study is trialling the antibiotic on approximately 400 asthmatics in four cities and is the biggest study into non-eosinophilic asthma in the world.  It is funded by the National Health and Medical Research Council.

Visit the Priority Research Centre for Asthma and Respiratory Diseases website

Visit the Hunter Medical Research Institute (HMRI) website

Joining forces to ease the wheeze

Joining forces to ease the wheeze

Australia's two million sufferers of airway disease can breathe easier thanks to the work of the University's groundbreaking respiratory researchers Professors Paul Foster and Peter Gibson.

Read more

Career Summary

Biography

Professor Paul Foster is the Director of the Priority Research Centre for Healthy Lungs; the Virus, Infection/Immunity, Vaccines and Asthma Program, Hunter Medical Research Institute and the Cooperative Research Centre (CRC) for Asthma and Airways (Newcastle node). He also currently holds the Chair of Immunology, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle. He is also a visiting Professor at Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

He serves as an Associate Editor of the American Journal of Respiratory Cell and Molecular Biology and the Journal of Pharmacology and Therapeutics, and is on the Editorial Boards of a number of leading international immunology/allergy journals. Professor Foster's research focuses on understanding the molecular and cellular basis of asthma, allergy, respiratory disorders, and chronic inflammation.

His research program focuses on translational approaches directed towards the development of novel anti-inflammatory therapies. Professor Foster's research findings are published in the most highly ranked medical and biomedical science journals (e.g. Nature Immunology and Journal of Experimental Medicine). Essential Science Indicators metrics places his team on the forefront of his field internationally. Professor Foster receives numerous and ongoing invitations to speak and chair sessions and leading international conferences in immunology and respiratory medicine (e.g. American Academy of Asthma, Allergy and Immunology, Keystone, Cold Spring Harbor, International Congress on Immunology and International Eosinophil meeting).

The importance of his team's work has been recognised through award of over $10.5 million in direct funding (since 2003) through Australian national competitive grants. Since 1995 Professor Foster's laboratory has focused on the biology of T cells and granulocytes, and on signaling by cytokines and chemokines pertinent to regulating allergic inflammatory responses, in particular asthma.

In the last 5 years we have extended our focus to understanding the relationship between inflammation induced by infection (viruses, bacteria and microbial products), at various times through life, on the subsequent development of the T cell repertoire and on chronic inflammation in the lung. A focus on the role of microRNAs in the regulation of inflammation is also a main focus. Professor Foster's activities have been supported through grants from the NHMRC (program and project grants), Australian Research Council (Discovery and LIEF grants), Human Frontiers Science Foundation, and through the CRC for Asthma and Airways. Professor Foster actively contributes to peer review at a national and international level (e.g. NHMRC; fellowship, program and project reviews/grant panel; Wellcome Trust; and leading international journals (e.g. J. of Clin. Invest., J. of Exp. Med., and Nature).

Professor Foster is also on the Editorial Board of:
• American Journal of Respiratory Cell & Molecular Biology • Pharmacology & Therapeutics (Associate Editor)
• Current Molecular Medicine
• Journal Inflammation and Allergy
• Clinical and Experimental Allergy

Research Expertise

Current research in my laboratory primarily aims at defining the key cellular and molecular processes that underlie the development of allergic disease (lung, skin and gastrointestinal tract) and of viral (RSV and influenza) induced pulmonary inflammation. We are particularly interested in the molecular events that predispose to remodeling of the airways in chronic disease and the subsequent impact on lung function. In particular, projects are focusing on the biology of CD4+ Th2 cells, CD8+ T cells and eosinophils, and in signaling arrangements between cytokine and chemokine systems that pertain to allergic disease, viral induced pathogenesis and viral induced exacerbation of asthma.

Our aim is to develop integrative concepts on molecular mechanisms of pathogenesis by employing an approach that is multifactorial ranging from transgenic systems to the identification of novel gene products. The laboratory has established in vivo models of asthma (acute and chronic), allergic cutaneous disease and of eosinophil and lymphocyte homing to sites of allergen or viral provocation.

Models of RSV infection in the presence and absence of allergic inflammation are also established. These models, in conjunction with mice that are factor deficient or transgenic (constitutive and inducible systems that are airway specific, and T cell transgenic systems), are currently being employed to define the individual role of inflammatory cells and cytokines/chemokines in the pathophysiology of allergic and viral disorders and viral induced exacerbation of allergic inflammation. Collectively, this approach is providing a fundamental platform for the identification of key targets for potential therapeutic intervention in these diseased states and models for the development of novel anti-inflammatory approaches. Models of leukocyte trafficking and pathogenesis are combined with experimental programs at a cellular level to enhance the understanding of the molecular basis of disease. Novel mechanisms to attenuate allergic and viral induced disease are also being explored. We have also established models of chronic obstructive pulmonary disease (COPD).

Current PhD and Honours projects within my team aim to gather an understanding in:
• the role of miRNA in asthma and infection
• the role of viruses in inducing asthma and COPD
• miRNA regulation of leukocyte differentiation
• the innate immune system in severe asthma

Teaching Expertise
• Immunology
• Research Commercialisation

Administrative Expertise
• Hunter Medical Research Institute Building Committee
• Research Committee - Member
• Academic Senate - Member
• Animal Services Research Facility, Advisory Committee, Sub-committee - Member
• Analytical and Biomolecular Research Facility Advisory
• Strategic Research Advisory Panel HMRI - Member
• Research Committee, School of Biomedical Sciences and Pharmacy, University of Newcastle - Member
• Steering Committee, Vaccines, Infection, Virus and Asthma Group, HMRI - Member

Collaborations
I have extensive national and international collaborations and associations with leading investigators and biotechnology and pharmaceutical companies. For example:
• Professor Andrew Mackenzie, Laboratory of Molecular Biology, Cambridge University, UK.
• Professor K Takeda and S Akira, Osaka University, Osaka Japan.
• Professor Marc Rothenberg, Children’s Hospital Medical Centre, Cincinnati, OH.
• Professor Helene Rosenberg, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA.
• Professor Richard Stevens, Harvard Medical School, Boston MA.
• Professor Sebastian Johnston, Imperial College, London UK.
• Professor Pardric Fallon, Trinity College, Dublin, Ireland.
• GSK.
• MedImmune Inc, Washington DC, USA.
• Commonwealth Serum Laboratories, Parkville, Melbourne, Australia.


Qualifications

  • PhD, Australian National University
  • Bachelor of Science (Honours), University of Western Australia

Keywords

  • Allergy
  • Asthma
  • Biomedical Sciences
  • Chronic Inflammation
  • Immunology
  • Leukocyte Biology
  • Medicine
  • Pharmacy

Fields of Research

Code Description Percentage
110799 Immunology not elsewhere classified 75
110299 Cardiorespiratory Medicine and Haematology not elsewhere classified 25

Professional Experience

UON Appointment

Title Organisation / Department
Professor University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

Dates Title Organisation / Department
Associate Editor - Pharmacology & Therapeutics Pharmacology & Therapeutics
Australia
1/01/2010 -  Visiting Professorship Harvard University
United States
1/01/2008 -  Editor - Clinical and Experimental Allergy Clinical and Experimental Allergy
Australia
1/01/2008 -  Editor - Journal Inflammation and Allergy Journal Inflammation and Allergy
Australia
1/01/2003 -  Professor University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/2003 -  Professor Australian National University
Allergy & Inflammation Research Group
Australia
1/01/2002 -  Editor - American Journal of Respiratory Cell and Molecular Biology American Journal of Respiratory Cell and Molecular Biology
United States
1/01/1999 - 1/12/2002 Senior Fellow Australian National University
Allergy & Inflammation Research Group
Australia
1/01/1996 - 1/12/1998 Fellow Australian National University
Leucocyte Signalling & Regulation Laboratory
Australia

Membership

Dates Title Organisation / Department
Member - International Eosinophil Society International Eosinophil Society
Australia
Member - International Mucosal Immunology Society International Mucosal Immunology Society
Australia
Member - American Society for Immunology American Society for Immunology
United States
Member - The Australian Lung foundation The Australian Lung foundation
Australia
Member - The Thoracic Society of Australia and New Zealand The Thoracic Society of Australia and New Zealand
Australia
Member - The Australian Society for Immunolgy The Australian Society for Immunolgy
Australia
1/01/2003 -  Membership - CRC for Asthma and Airwaysa CRC for Asthma and Airways
Australia
1/01/2003 - 31/12/2003 ARC Committee member ARC
Australia

Awards

Recipient

Year Award
2005 CRC for Asthma and Airways
University of Newcastle
2003 NHMRC Programme Grant 2003-2007
Australian National University

Research Award

Year Award
2010 Research Excellence
Hunter Medical Research Institute (HMRI)
1999 Australian Academy of Science and The Royal Society Travelling Fellowship
The Australian Academy of Science
1997 Human Frontiers Science Programme International Collaborative Grant
Human Frontier Science Program
1996 The Asthma Foundation of NSW, The Jean Jeavons grant for Asthma Research
Asthma Foundation of New South Wales
1996 The British council Collaborative Research Award
British Council
1996 The John curtin School of Medical Research, Howard Florey Young Investigators Award
Australian National University
1994 Australian Academy of Science and The Royal Society Travelling Fellowship
The Australian Academy of Science
1983 Commonwealth Postgraduate Research Scholarship
Commonwealth

Invitations

Participant

Year Title / Rationale
2010 Congress of the European Academy of Allergy and Clinical Immunology
Organisation: 29th Conference Description:
2010 The American Academy of Asthma, Allergy and Immunology (AAAAI)
Organisation: 65th Annual Meeting - Mini-symposium (educational section) Description:
2009 Biennial Symposium International Eosinophil Society
Organisation: 6th Conference Description:
2009 The American Academy of Asthma, Allergy and Immunology (AAAAI)
Organisation: 64th Annual Meeting - Mini-symposium (educational section) Description:
2008 The American Academy of Asthma, Allergy and Immunology (AAAAI)
Organisation: 63nd Annual Meeting - Mini-symposium (educational section). Description:
2007 Molecular Therapeutics of Cancer
Organisation: Gordon Conference Description:
2007 Biennial Symposium International Eosinophil Society
Organisation: 5th Conference Description:
2007 International Congress of Immunology
Organisation: 14th Conference Description:
2006 The American Academy of Asthma, Allergy and Immunology (AAAAI)
Organisation: 61st Annual Meeting - Mini-symposium (educational section) Description:
2005 The American Academy of Asthma, Allergy and Immunology (AAAAI)
Organisation: 60th Annual Meeting - Symposium Chemokines and Receptors Description:
2004 12th International Congress on Immunology
Organisation: 4th Annual Conerence of FOCIS Description:
2004 25th International Symposium
Organisation: Collegium Internationalale Allergologicum Description:
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (7 outputs)

Year Citation Altmetrics Link
2015 Maltby S, Plank M, Ptaschinski C, Mattes J, Foster PS, 'MicroRNA function in mast cell biology: Protocols to characterize and modulate MicroRNA expression', Mast Cells: Methods and Protocols, Springer, New York 287-304 (2015) [B1]
DOI 10.1007/978-1-4939-1568-2_18
Citations Scopus - 3
Co-authors Joerg Mattes, Steven Maltby
2013 Lee JJ, Ptaschinski C, Plank M, Mattes J, Foster PS, Balla KM, et al., 'Emerging Concepts', Eosinophils in Health and Disease, Academic Press, London 607-641 (2013) [B1]
DOI 10.1016/B978-0-12-394385-9.00016-X
Co-authors Joerg Mattes
2008 Hogan SP, Rosenberg HF, Moqbel R, Phipps S, Foster PS, Lacy P, et al., 'Eosinophils: Biological properties and role in health and allergic diseases', Allergy and Allergic Diseases, Wiley-Blackwell, Hoboken 258-294 (2008) [B1]
Citations Web of Science - 332
2004 Kumar RL, Foster PS, 'Lessons from a model of chronic asthma', Focus on Asthma, Nova Science Publishers, New York, United States 165-183 (2004) [B1]
2000 Simson L, Foster PS, 'Chemokine and Cytokine Cooperativity', Chemokines in Allergic Disease, Marcel Dekker, New York, USA 289-309 (2000) [B1]
1999 Ramsay A, Hogan S, Foster PS, Xiong Y, 'Gene therapy of allergic airways inflammation', Progress in Inflammation Research: Gene Therapy of Inflammatory Diseases, Birkhauser Publishing, Basel, Switzerland 65-72 (1999) [B1]
1999 Foster PS, Hogan S, Matthaei K, Young I, 'The role of interleukin-5 in allergic airways disease.', Interleukin-5, Marcel Dekker, New York, USA 127-135 (1999) [B1]
Show 4 more chapters

Journal article (227 outputs)

Year Citation Altmetrics Link
2016 Munitz A, Karo-Atar D, Foster PS, 'Asthma diagnosis: MicroRNAs to the rescue', Journal of Allergy and Clinical Immunology, 137 1447-1448 (2016)
DOI 10.1016/j.jaci.2016.02.013
2016 Haw TJ, Starkey MR, Nair PM, Pavlidis S, Liu G, Nguyen DH, et al., 'A pathogenic role for tumor necrosis factor-related apoptosis-inducing ligand in chronic obstructive pulmonary disease', Mucosal Immunology, 9 859-872 (2016) [C1]

Chronic obstructive pulmonary disease (COPD) is a life-Threatening inflammatory respiratory disorder, often induced by cigarette smoke (CS) exposure. The development of effective ... [more]

Chronic obstructive pulmonary disease (COPD) is a life-Threatening inflammatory respiratory disorder, often induced by cigarette smoke (CS) exposure. The development of effective therapies is impaired by a lack of understanding of the underlining mechanisms. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine with inflammatory and apoptotic properties. We interrogated a mouse model of CS-induced experimental COPD and human tissues to identify a novel role for TRAIL in COPD pathogenesis. CS exposure of wild-Type mice increased TRAIL and its receptor messenger RNA (mRNA) expression and protein levels, as well as the number of TRAIL + CD11b + monocytes in the lung. TRAIL and its receptor mRNA were also increased in human COPD. CS-exposed TRAIL-deficient mice had decreased pulmonary inflammation, pro-inflammatory mediators, emphysema-like alveolar enlargement, and improved lung function. TRAIL-deficient mice also developed spontaneous small airway changes with increased epithelial cell thickness and collagen deposition, independent of CS exposure. Importantly, therapeutic neutralization of TRAIL, after the establishment of early-stage experimental COPD, reduced pulmonary inflammation, emphysema-like alveolar enlargement, and small airway changes. These data provide further evidence for TRAIL being a pivotal inflammatory factor in respiratory diseases, and the first preclinical evidence to suggest that therapeutic agents that target TRAIL may be effective in COPD therapy.

DOI 10.1038/mi.2015.111
Co-authors Jay Horvat, Darryl Knight, Joerg Mattes, Malcolm Starkey, Peter Wark, Alan Hsu, Philip Hansbro
2016 Nguyen TH, Maltby S, Simpson JL, Eyers F, Baines KJ, Gibson PG, et al., 'TNF-a and macrophages are critical for respiratory syncytial virus-induced exacerbations in a mouse model of allergic airways disease', Journal of Immunology, 196 3547-3558 (2016) [C1]

Viral respiratory infections trigger severe exacerbations of asthma, worsen disease symptoms, and impair lung function. To investigate the mechanisms underlying viral exacerbation... [more]

Viral respiratory infections trigger severe exacerbations of asthma, worsen disease symptoms, and impair lung function. To investigate the mechanisms underlying viral exacerbation, we established a mouse model of respiratory syncytial virus (RSV)-induced exacerbation after allergen sensitization and challenge. RSV infection of OVA-sensitized/challenged BALB/c mice resulted in significantly increased airway hyperresponsiveness (AHR) and macrophage and neutrophil lung infiltration. Exacerbation was accompanied by increased levels of inflammatory cytokines (including TNF-a, MCP-1, and keratinocyte-derived protein chemokine [KC]) compared with uninfected OVA-treated mice or OVA-treated mice exposed to UV-inactivated RSV. Dexamethasone treatment completely inhibited all features of allergic disease, including AHR and eosinophil infiltration, in uninfected OVAsensitized/challenged mice. Conversely, dexamethasone treatment following RSV-induced exacerbation only partially suppressed AHR and failed to dampen macrophage and neutrophil infiltration or inflammatory cytokine production (TNF-a, MCP-1, and KC). This mimics clinical observations in patients with exacerbations, which is associated with increased neutrophils and often poorly responds to corticosteroid therapy. Interestingly, we also observed increased TNF-a levels in sputum samples from patients with neutrophilic asthma. Although RSV-induced exacerbation was resistant to steroid treatment, inhibition of TNF-a and MCP-1 function or depletion of macrophages suppressed features of disease, including AHR and macrophage and neutrophil infiltration. Our findings highlight critical roles for macrophages and inflammatory cytokines (including TNF-a and MCP-1) in viral-induced exacerbation of asthma and suggest examination of these pathways as novel therapeutic approaches for disease management.

DOI 10.4049/jimmunol.1502339
Co-authors Peter Gibson, Katherine Baines, Jodie Simpson, Steven Maltby, Ming Yang
2016 Thorburn AN, Tseng HY, Donovan C, Hansbro NG, Jarnicki AG, Foster PS, et al., 'TLR2, TLR4 AND MyD88 Mediate Allergic Airway Disease (AAD) and Streptococcus pneumoniae-Induced Suppression of AAD.', PLoS One, 11 e0156402 (2016)
DOI 10.1371/journal.pone.0156402
Co-authors Philip Hansbro, Peter Gibson
2016 Kumar RK, Herbert C, Foster PS, 'Mouse models of acute exacerbations of allergic asthma', Respirology, (2016) [C1]

© 2016 Asian Pacific Society of Respirology.Most of the healthcare costs associated with asthma relate to emergency department visits and hospitalizations because of acute exacer... [more]

© 2016 Asian Pacific Society of Respirology.Most of the healthcare costs associated with asthma relate to emergency department visits and hospitalizations because of acute exacerbations of underlying chronic disease. Development of appropriate animal models of acute exacerbations of asthma is a necessary prerequisite for understanding pathophysiological mechanisms and assessing potential novel therapeutic approaches. Most such models have been developed using mice. Relatively few mouse models attempt to simulate the acute-on-chronic disease that characterizes human asthma exacerbations. Instead, many reported models involve relatively short-term challenge with an antigen to which animals are sensitized, followed closely by an unrelated triggering agent, so are better described as models of potentiation of acute allergic inflammation. Triggers for experimental models of asthma exacerbations include (i) challenge with high levels of the sensitizing allergen (ii) infection by viruses or fungi, or challenge with components of these microorganisms (iii) exposure to environmental pollutants. In this review, we examine the strengths and weaknesses of published mouse models, their application for investigation of novel treatments and potential future developments.

DOI 10.1111/resp.12760
2016 Xiang Y, Eyers F, Herbert C, Tay HL, Foster PS, Yang M, 'MicroRNA-487b Is a Negative Regulator of Macrophage Activation by Targeting IL-33 Production.', J Immunol, 196 3421-3428 (2016)
DOI 10.4049/jimmunol.1502081
Citations Scopus - 1Web of Science - 1
Co-authors Ming Yang
2016 Zhou H, Zhang J, Eyers F, Xiang Y, Herbert C, Tay HL, et al., 'Identification of the microRNA networks contributing to macrophage differentiation and function.', Oncotarget, (2016)
DOI 10.18632/oncotarget.8933
Co-authors Ming Yang
2015 Herbert C, Sebesfi M, Zeng QX, Oliver BG, Foster PS, Kumar RK, 'Using multiple online databases to help identify microRNAs regulating the airway epithelial cell response to a virus-like stimulus', Respirology, 20 1206-1212 (2015) [C1]

© 2015 Asian Pacific Society of Respirology.Background and objective Exacerbations of allergic asthma are often triggered by respiratory viral infections. We have previously show... [more]

© 2015 Asian Pacific Society of Respirology.Background and objective Exacerbations of allergic asthma are often triggered by respiratory viral infections. We have previously shown that in a T-helper type 2 (Th2)-biased cytokine environment, mouse and human airway epithelial cells (AEC) exhibit increased expression of pro-inflammatory and anti-viral genes in response to synthetic double-stranded ribonucleic acid (dsRNA), a virus-like stimulus. This implies coordinated regulation of gene expression, suggesting possible involvement of microRNA. To investigate this, we developed a novel approach to identifying candidate microRNA using online databases, then confirmed their expression by quantitative real-time polymerase chain reaction (qRT-PCR). Methods Using a list of genes of interest, defined on the basis of the previous study as being up-regulated in a Th2 environment, we searched mouse and human microRNA databases for possible regulatory microRNA, and selected 10 candidates that were conserved across species or predicted by more than one human database. Expression of these microRNA was tested by qRT-PCR, in primary human AEC pre-treated with Th2 cytokines and exposed to dsRNA. Results Expression of hsa-miR-139-5p, miR-423-5p and miR-542-3p was significantly decreased in Th2 pre-treated AEC, and miR-135a-5p exhibited a trend towards decreased expression. Further database searches confirmed that these microRNA regulated additional pro-inflammatory and anti-viral response genes for which expression had previously been shown to be up-regulated, confirming the validity of this approach. Conclusions Our study demonstrates the value of using multiple online databases to identify candidate regulatory microRNA and provides the first evidence that in an allergic environment, microRNA may be important in altering the pro-inflammatory and anti-viral responses of human AEC during exacerbations of asthma. The potential role of microRNA in regulating the pro-inflammatory and anti-viral responses of airway epithelial cells in asthma was investigated. We devised a novel approach for identification of candidate microRNA using online databases and showed that in vitro, several of these microRNA were significantly down-regulated in a Th2 cytokine environment. See Editorial, page 1149

DOI 10.1111/resp.12606
Citations Scopus - 2Web of Science - 2
2015 Siggs OM, Miosge LA, Daley SR, Asquith K, Foster PS, Liston A, Goodnow CC, 'Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation', Journal of Immunology, 194 2587-2595 (2015) [C1]

Copyright © 2015 by The American Association of Immunologists, Inc.Gene variants that disrupt TCR signaling can cause severe immune deficiency, yet less disruptive variants are s... [more]

Copyright © 2015 by The American Association of Immunologists, Inc.Gene variants that disrupt TCR signaling can cause severe immune deficiency, yet less disruptive variants are sometimes associated with immune pathology. Null mutations of the gene encoding the scaffold protein Src homology 2 domain-containing leukocyte protein of 76 kDa (SLP-76), for example, cause an arrest of T cell positive selection, whereas a synthetic membrane-targeted allele allows limited positive selection but is associated with proinflammatory cytokine production and autoantibodies. Whether these and other enigmatic outcomes are due to a biochemical uncoupling of tolerogenic signaling, or simply a quantitative reduction of protein activity, remains to be determined. In this study we describe a splice variant of Lcp2 that reduced the amount of wild-type SLP-76 protein by ~90%, disrupting immunogenic and tolerogenic pathways to different degrees. Mutant mice produced excessive amounts of proinflammatory cytokines, autoantibodies, and IgE, revealing that simple quantitative reductions of SLP-76 were sufficient to trigger immune dysregulation. This allele reveals a dose-sensitive threshold for SLP-76 in the balance of immunity and immune dysregulation, a common disturbance of atypical clinical immune deficiencies.

DOI 10.4049/jimmunol.1400326
Citations Scopus - 1Web of Science - 1
2015 Essilfie A, Horvat JC, Kim RY, Mayall JR, Pinkerton JW, Beckett EL, et al., 'Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma', Thorax Journal, 70 458-467 (2015) [C1]
DOI 10.1136/thoraxjnl-2014-206067
Citations Scopus - 12Web of Science - 12
Co-authors Peter Gibson, Philip Hansbro, Jay Horvat, Malcolm Starkey, Jodie Simpson
2015 Foo SY, Zhang V, Lalwani A, Lynch JP, Zhuang A, Lam CE, et al., 'Regulatory T Cells Prevent Inducible BALT Formation by Dampening Neutrophilic Inflammation', JOURNAL OF IMMUNOLOGY, 194 4567-4576 (2015) [C1]
DOI 10.4049/jimmunol.1400909
Citations Scopus - 2Web of Science - 2
2015 Mateer SW, Maltby S, Marks E, Foster PS, Horvat JC, Hansbro PM, Keely S, 'Potential mechanisms regulating pulmonary pathology in inflammatory bowel disease.', J Leukoc Biol, 98 727-737 (2015) [C1]
DOI 10.1189/jlb.3RU1114-563R
Co-authors Simon Keely, Philip Hansbro, Jay Horvat, Steven Maltby
2015 Su Y-C, Townsend D, Herrero LJ, Zaid A, Rolph MS, Gahan ME, et al., 'Dual Proinflammatory and Antiviral Properties of Pulmonary Eosinophils in Respiratory Syncytial Virus Vaccine-Enhanced Disease', JOURNAL OF VIROLOGY, 89 1564-1578 (2015) [C1]
DOI 10.1128/JVI.01536-14
Citations Scopus - 2Web of Science - 2
2015 Tay HL, Kaiko GE, Plank M, Li J, Maltby S, Essilfie AT, et al., 'Correction: Antagonism of miR-328 Increases the Antimicrobial Function of Macrophages and Neutrophils and Rapid Clearance of Non-typeable Haemophilus Influenzae (NTHi) from Infected Lung.', PLoS pathogens, 11 e1004956 (2015) [O1]
Citations Scopus - 2
Co-authors Steven Maltby, Ming Yang, Philip Hansbro, Joerg Mattes
2015 Li JJ, Tay HL, Maltby S, Xiang Y, Eyers F, Hatchwell L, et al., 'MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity', Journal of Allergy and Clinical Immunology, 136 462-473 (2015) [C1]

© 2015 American Academy of Allergy, Asthma & Immunology.Background Steroid-resistant asthma is a major clinical problem that is linked to activation of innate immune cells. Level... [more]

© 2015 American Academy of Allergy, Asthma & Immunology.Background Steroid-resistant asthma is a major clinical problem that is linked to activation of innate immune cells. Levels of IFN-¿ and LPS are often increased in these patients. Cooperative signaling between IFN-¿/LPS induces macrophage-dependent steroid-resistant airway hyperresponsiveness (AHR) in mouse models. MicroRNAs (miRs) are small noncoding RNAs that regulate the function of innate immune cells by controlling mRNA stability and translation. Their role in regulating glucocorticoid responsiveness and AHR remains unexplored. Objective IFN-¿ and LPS synergistically increase the expression of miR-9 in macrophages and lung tissue, suggesting a role in the mechanisms of steroid resistance. Here we demonstrate the role of miR-9 in IFN-¿/LPS-induced inhibition of dexamethasone (DEX) signaling in macrophages and in induction of steroid-resistant AHR. Methods MiRNA-9 expression was assessed by means of quantitative RT-PCR. Putative miR-9 targets were determined in silico and confirmed in luciferase reporter assays. miR-9 function was inhibited with sequence-specific antagomirs. The efficacy of DEX was assessed by quantifying glucocorticoid receptor (GR) cellular localization, protein phosphatase 2A (PP2A) activity, and AHR. Results Exposure of pulmonary macrophages to IFN-¿/LPS synergistically induced miR-9 expression; reduced levels of its target transcript, protein phosphatase 2 regulatory subunit B (B56) d isoform; attenuated PP2A activity; and inhibited DEX-induced GR nuclear translocation. Inhibition of miR-9 increased both PP2A activity and GR nuclear translocation in macrophages and restored steroid sensitivity in multiple models of steroid-resistant AHR. Pharmacologic activation of PP2A restored DEX efficacy and inhibited AHR. MiR-9 expression was increased in sputum of patients with neutrophilic but not those with eosinophilic asthma. Conclusion MiR-9 regulates GR signaling and steroid-resistant AHR. Targeting miR-9 function might be a novel approach for the treatment of steroid-resistant asthma.

DOI 10.1016/j.jaci.2014.11.044
Citations Scopus - 13Web of Science - 12
Co-authors Joerg Mattes, Steven Maltby, Ming Yang
2015 Kim RY, Horvat JC, Pinkerton JW, Starkey MR, Essilfie AT, Mayall JR, et al., 'MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2', Journal of Allergy and Clinical Immunology, (2015)

© 2016 American Academy of Allergy, Asthma & Immunology.Background: Severe steroid-insensitive asthma is a substantial clinical problem. Effective treatments are urgently require... [more]

© 2016 American Academy of Allergy, Asthma & Immunology.Background: Severe steroid-insensitive asthma is a substantial clinical problem. Effective treatments are urgently required, however, their development is hampered by a lack of understanding of the mechanisms of disease pathogenesis. Steroid-insensitive asthma is associated with respiratory tract infections and noneosinophilic endotypes, including neutrophilic forms of disease. However, steroid-insensitive patients with eosinophil-enriched inflammation have also been described. The mechanisms that underpin infection-induced, severe steroid-insensitive asthma can be elucidated by using mouse models of disease. Objective: We sought to develop representative mouse models of severe, steroid-insensitive asthma and to use them to identify pathogenic mechanisms and investigate new treatment approaches. Methods: Novel mouse models of . Chlamydia, . Haemophilus influenzae, influenza, and respiratory syncytial virus respiratory tract infections and ovalbumin-induced, severe, steroid-insensitive allergic airway disease (SSIAAD) in BALB/c mice were developed and interrogated. Results: Infection induced increases in the levels of microRNA (miRNA)-21 (miR-21) expression in the lung during SSIAAD, whereas expression of the miR-21 target phosphatase and tensin homolog was reduced. This was associated with an increase in levels of phosphorylated Akt, an indicator of phosphoinositide 3-kinase (PI3K) activity, and decreased nuclear histone deacetylase (HDAC)2 levels. Treatment with an miR-21-specific antagomir (Ant-21) increased phosphatase and tensin homolog levels. Treatment with Ant-21, or the pan-PI3K inhibitor LY294002, reduced PI3K activity and restored HDAC2 levels. This led to suppression of airway hyperresponsiveness and restored steroid sensitivity to allergic airway disease. These observations were replicated with SSIAAD associated with 4 different pathogens. Conclusion: We identify a previously unrecognized role for an miR-21/PI3K/HDAC2 axis in SSIAAD. Our data highlight miR-21 as a novel therapeutic target for the treatment of this form of asthma.

DOI 10.1016/j.jaci.2016.04.038
Co-authors Malcolm Starkey, Philip Hansbro, Simon Keely, Jay Horvat, Joerg Mattes
2015 Hatchwell L, Collison A, Girkin J, Parsons K, Li J, Zhang J, et al., 'Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia', Thorax, (2015) [C1]

© 2015 BMJ Publishing Group Ltd & British Thoracic Society.Background Asthma exacerbations represent a significant disease burden and are commonly caused by rhinovirus (RV), whic... [more]

© 2015 BMJ Publishing Group Ltd & British Thoracic Society.Background Asthma exacerbations represent a significant disease burden and are commonly caused by rhinovirus (RV), which is sensed by Toll-like receptors (TLR) such as TLR7. Some asthmatics have impaired interferon (IFN) responses to RV, but the underlying mechanisms of this clinically relevant observation are poorly understood. Objectives To investigate the importance of intact TLR7 signalling in vivo during RV exacerbation using mouse models of house dust mite (HDM)-induced allergic airways disease exacerbated by a superimposed RV infection. Methods Wild-type and TLR7-deficient (Tlr7-/-) BALB/c mice were intranasally sensitised and challenged with HDM prior to infection with RV1B. In some experiments, mice were administered recombinant IFN or adoptively transferred with plasmacytoid dendritic cells (pDC). Results Allergic Tlr7-/- mice displayed impaired IFN release upon RV1B infection, increased virus replication and exaggerated eosinophilic inflammation and airways hyper reactivity. Treatment with exogenous IFN or adoptive transfer of TLR7-competent pDCs blocked these exaggerated inflammatory responses and boosted IFN? release in the absence of host TLR7 signalling. TLR7 expression in the lungs was suppressed by allergic inflammation and by interleukin (IL)-5-induced eosinophilia in the absence of allergy. Subjects with moderate-to-severe asthma and eosinophilic but not neutrophilic airways inflammation, despite inhaled steroids, showed reduced TLR7 and IFN?2/3 expression in endobronchial biopsies. Furthermore, TLR7 expression inversely correlated with percentage of sputum eosinophils. Conclusions This implicates IL-5-induced airways eosinophilia as a negative regulator of TLR7 expression and antiviral responses, which provides a molecular mechanism underpinning the effect of eosinophil-targeting treatments for the prevention of asthma exacerbations.

DOI 10.1136/thoraxjnl-2014-205465
Citations Scopus - 10Web of Science - 10
Co-authors Peter Wark, Joerg Mattes, Nathan Bartlett, Darryl Knight
2015 Hsu ACY, Starkey MR, Hanish I, Parsons K, Haw TJ, Howland LJ, et al., 'Targeting PI3K-p110a suppresses influenza virus infection in chronic obstructive pulmonary disease', American Journal of Respiratory and Critical Care Medicine, 191 1012-1023 (2015) [C1]

Copyright © 2015 by the American Thoracic Society.Rationale: Chronic obstructive pulmonary disease (COPD) and influenza virus infections are major global health issues. Patients ... [more]

Copyright © 2015 by the American Thoracic Society.Rationale: Chronic obstructive pulmonary disease (COPD) and influenza virus infections are major global health issues. Patients with COPD are more susceptible to infection, which exacerbates their condition and increases morbidity and mortality. The mechanisms of increased susceptibility remain poorly understood, and current preventions and treatments have substantial limitations. Objectives: To characterize the mechanisms of increased susceptibility to influenza virus infection in COPD and the potential for therapeutic targeting. Methods: We used a combination of primary bronchial epithelial cells (pBECs) from COPD and healthy control subjects, a mouse model of cigarette smoke-induced experimental COPD, and influenza infection. The role of the phosphoinositide-3-kinase (PI3K) pathway was characterized using molecular methods, and its potential for targeting assessed using inhibitors. Measurements and Main Results: COPDpBECs were susceptible to increased viral entry and replication. Infected mice with experimental COPD also had more severe infection (increased viral titer and pulmonary inflammation, and compromised lung function). These processes were associated with impaired antiviral immunity, reduced retinoic acid-inducible gene-I, and IFN/cytokine and chemokine responses. Increased PI3K-p110a levels and activity inCOPDpBECs and/or mice were responsible for increased infection and reduced antiviral responses. Global PI3K, specific therapeutic p110a inhibitors, or exogenous IFN-b restored protective antiviral responses, suppressed infection, and improved lung function. Conclusions: The increased susceptibility of individuals with COPD to influenza likely results from impaired antiviral responses, which are mediated by increased PI3K-p110a activity. This pathway may be targeted therapeutically in COPD, or in healthy individuals, during seasonal or pandemic outbreaks to prevent and/or treat influenza.

DOI 10.1164/rccm.201501-0188OC
Citations Scopus - 12Web of Science - 10
Co-authors Alan Hsu, Malcolm Starkey, Darryl Knight, Philip Hansbro, Peter Wark
2015 Plank MW, Maltby S, Tay HL, Stewart J, Eyers F, Hansbro PM, Foster PS, 'MicroRNA Expression Is Altered in an Ovalbumin-Induced Asthma Model and Targeting miR-155 with Antagomirs Reveals Cellular Specificity.', PloS one, 10 1-25 (2015) [C1]
DOI 10.1371/journal.pone.0144810
Citations Scopus - 1Web of Science - 1
Co-authors Philip Hansbro, Steven Maltby
2015 Girkin J, Hatchwell L, Foster P, Johnston SL, Bartlett N, Collison A, Mattes J, 'CCL7 and IRF-7 mediate hallmark inflammatory and IFN responses following rhinovirus 1B infection', Journal of Immunology, 194 4924-4930 (2015) [C1]

Copyright © 2015 by The American Association of Immunologists, Inc.Rhinovirus (RV) infections are common and have the potential to exacerbate asthma. We have determined the lung ... [more]

Copyright © 2015 by The American Association of Immunologists, Inc.Rhinovirus (RV) infections are common and have the potential to exacerbate asthma. We have determined the lung transcriptome in RV strain 1B-infected naive BALB/c mice (nonallergic) and identified CCL7 and IFN regulatory factor (IRF)-7 among the most upregulated mRNA transcripts in the lung. To investigate their roles we employed anti-CCL7 Abs and an IRF-7-targeting small interfering RNA in vivo. Neutralizing CCL7 or inhibiting IRF-7 limited neutrophil and macrophage influx and IFN responses in nonallergic mice. Neutralizing CCL7 also reduced activation of NF-¿B p65 and p50 subunits, as well as airway hyperreactivity (AHR) in nonallergic mice. However, neither NF-¿B subunit activation nor AHR was abolished with infection of allergic mice after neutralizing CCL7, despite a reduction in the number of neutrophils, macrophages, and eosinophils. IRF-7 small interfering RNA primarily suppressed IFN-a and IFN-b levels during infection of allergic mice. Our data highlight a pivotal role of CCL7 and IRF-7 in RV-induced inflammation and IFN responses and link NF-¿B signaling to the development of AHR.

DOI 10.4049/jimmunol.1401362
Citations Scopus - 7Web of Science - 7
Co-authors Joerg Mattes, Nathan Bartlett
2015 Tay HL, Kaiko GE, Plank M, Li JJ, Maltby S, Essilfie AT, et al., 'Antagonism of miR-328 Increases the Antimicrobial Function of Macrophages and Neutrophils and Rapid Clearance of Non-typeable Haemophilus Influenzae (NTHi) from Infected Lung', PLoS Pathogens, 11 (2015) [C1]

© 2015 Tay et al.Pathogenic bacterial infections of the lung are life threatening and underpin chronic lung diseases. Current treatments are often ineffective potentially due to ... [more]

© 2015 Tay et al.Pathogenic bacterial infections of the lung are life threatening and underpin chronic lung diseases. Current treatments are often ineffective potentially due to increasing antibiotic resistance and impairment of innate immunity by disease processes and steroid therapy. Manipulation miRNA directly regulating anti-microbial machinery of the innate immune system may boost host defence responses. Here we demonstrate that miR-328 is a key element of the host response to pulmonary infection with non-typeable haemophilus influenzae and pharmacological inhibition in mouse and human macrophages augments phagocytosis, the production of reactive oxygen species, and microbicidal activity. Moreover, inhibition of miR-328 in respiratory models of infection, steroid-induced immunosuppression, and smoke-induced emphysema enhances bacterial clearance. Thus, miRNA pathways can be targeted in the lung to enhance host defence against a clinically relevant microbial infection and offer a potential new anti-microbial approach for the treatment of respiratory diseases.

DOI 10.1371/journal.ppat.1004549
Citations Scopus - 4Web of Science - 5
Co-authors Steven Maltby, Ming Yang, Philip Hansbro, Joerg Mattes
2015 Keely S, Foster PS, 'Stop Press: Eosinophils Drafted to Join the Th17 Team', IMMUNITY, 43 7-9 (2015) [C3]
DOI 10.1016/j.immuni.2015.07.010
Citations Scopus - 1
Co-authors Simon Keely
2014 Maltby S, Hansbro NG, Tay HL, Stewart J, Plank M, Donges B, et al., 'Production and differentiation of myeloid cells driven by proinflammatory cytokines in response to acute pneumovirus infection in mice.', J Immunol, 193 4072-4082 (2014) [C1]
DOI 10.4049/jimmunol.1400669
Citations Scopus - 3Web of Science - 2
Co-authors Nicole Hansbro, Steven Maltby
2014 Gibson PG, Foster PS, 'Asthma 2014: from monoclonals to the microbiome.', Lancet Respir Med, 2 956-958 (2014) [C3]
DOI 10.1016/S2213-2600(14)70275-9
Co-authors Peter Gibson
2014 Starkey MR, Nguyen DH, Essilfie AT, Kim RY, Hatchwell LM, Collison AM, et al., 'Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease.', Mucosal Immunol, 7 478-488 (2014) [C1]
DOI 10.1038/mi.2013.65
Citations Scopus - 4Web of Science - 2
Co-authors Malcolm Starkey, Philip Hansbro, Jay Horvat, Joerg Mattes
2014 Yang M, Eyers F, Xiang Y, Guo M, Young IG, Rosenberg HF, Foster PS, 'Expression profiling of differentiating eosinophils in bone marrow cultures predicts functional links between microRNAs and their target mRNAs', PLoS ONE, 9 (2014) [C1]

Background: MicroRNAs (miRNAs) are small non-coding RNAs that regulate complex transcriptional networks underpin immune responses. However, little is known about the specific miRN... [more]

Background: MicroRNAs (miRNAs) are small non-coding RNAs that regulate complex transcriptional networks underpin immune responses. However, little is known about the specific miRNA networks that control differentiation of specific leukocyte subsets. In this study, we profiled miRNA expression during differentiation of eosinophils from bone marrow (BM) progenitors (bmEos), and correlated expression with potential mRNA targets involved in crucial regulatory functions. Profiling was performed on whole BM cultures to document the dynamic changes in miRNA expression in the BM microenvironment over the differentiation period. miRNA for network analysis were identified in BM cultures enriched in differentiating eosinophils, and chosen for their potential ability to target mRNA of factors that are known to play critical roles in eosinophil differentiation pathways or cell identify. Methodology/Principal Findings: We identified 68 miRNAs with expression patterns that were up- or down- regulated 5-fold or more during bmEos differentiation. By employing TargetScan and MeSH databases, we identified 348 transcripts involved in 30 canonical pathways as potentially regulated by these miRNAs. Furthermore, by applying miRanda and Ingenuity Pathways Analysis (IPA), we identified 13 specific miRNAs that are temporally associated with the expression of IL-5Ra and CCR3 and 14 miRNAs associated with the transcription factors GATA-1/2, PU.1 and C/EBPe. We have also identified 17 miRNAs that may regulate the expression of TLRs 4 and 13 during eosinophil differentiation, although we could identify no miRNAs targeting the prominent secretory effector, eosinophil major basic protein. Conclusions/Significance: This is the first study to map changes in miRNA expression in whole BM cultures during the differentiation of eosinophils, and to predict functional links between miRNAs and their target mRNAs for the regulation of eosinophilopoiesis. Our findings provide an important resource that will promote the platform for further understanding of the role of these non-coding RNAs in the regulation of eosinophil differentiation and function. © 2014 Yang et al.

DOI 10.1371/journal.pone.0097537
Citations Scopus - 5Web of Science - 2
Co-authors Ming Yang
2014 Xiang Y, Eyers F, Young IG, Rosenberg HF, Foster PS, Yang M, 'Identification of MicroRNAs regulating the developmental pathways of bone marrow derived mast cells', PLoS ONE, 9 (2014) [C1]

Background: MicroRNAs (miRNAs) play important roles in leukocyte differentiation, although those utilised for specific programs and key functions remain incompletely characterised... [more]

Background: MicroRNAs (miRNAs) play important roles in leukocyte differentiation, although those utilised for specific programs and key functions remain incompletely characterised. As a global approach to gain insights into the potential regulatory role of miRNA in mast cell differentiation we characterised expression in BM cultures from the initiation of differentiation. In cultures enriched in differentiating mast cells we characterised miRNA expression and identified miRNA targeting the mRNA of putative factors involved in differentiation pathways and cellular identity. Detailed pathway analysis identified a unique miRNA network that is intimately linked to the mast cell differentiation program. Methodology/Principal Findings: We identified 86 unique miRNAs with expression patterns that were up- or down-regulated at 5-fold or more during bone marrow derived mast cells (BMMC) development. By employing TargetScan and MeSH databases, we identified 524 transcripts involved in 30 canonical pathways as potentially regulated by these specific 86 miRNAs. Furthermore, by applying miRanda and IPA analyses, we predict that 7 specific miRNAs of this group are directly associated with the expression of c-Kit and FceRIa and likewise, that 18 miRNAs promote expression of Mitf, GATA1 and c/EBPa three core transcription factors that direct mast cell differentiation. Furthermore, we have identified 11 miRNAs that may regulate the expression of STATs-3, -5a/b, GATA2 and GATA3 during differentiation, along with 13 miRNAs that target transcripts encoding Ndst2, mMCP4 and mMCP6 and thus may regulate biosynthesis of mast cell secretory mediators. Conclusions/ Significance: This investigation characterises changes in miRNA expression in whole BM cultures during the differentiation of mast cells and predicts functional links between miRNAs and their target mRNAs for the regulation of development. This information provides an important resource for further investigations of the contributions of miRNAs to mast cell differentiation and function. © 2014 Xiang et al.

DOI 10.1371/journal.pone.0098139
Citations Scopus - 8Web of Science - 8
Co-authors Ming Yang
2014 Hansbro PM, Hamilton MJ, Fricker M, Gellatly SL, Jarnicki AG, Zheng D, et al., 'Importance of mast cell Prss31/transmembrane tryptase/tryptase-¿ in lung function and experimental chronic obstructive pulmonary disease and colitis', Journal of Biological Chemistry, 289 18214-18227 (2014) [C1]

Protease serine member S31 (Prss31)/transmembrane tryptase/tryptase-¿ is a mast cell (MC)-restricted protease of unknown function that is retained on the outer leaflet of the pla... [more]

Protease serine member S31 (Prss31)/transmembrane tryptase/tryptase-¿ is a mast cell (MC)-restricted protease of unknown function that is retained on the outer leaflet of the plasma membrane when MCs are activated. We determined the nucleotide sequences of the Prss31 gene in different mouse strains and then used a Cre/loxP homologous recombination approach to create a novel Prss31 -/- C57BL/6 mouse line. The resulting animals exhibited no obvious developmental abnormality, contained normal numbers of granulated MCs in their tissues, and did not compensate for their loss of the membrane tryptase by increasing their expression of other granule proteases. When Prss31-null MCs were activated with a calcium ionophore or by their high affinity IgE receptors, they degranulated in a pattern similar to that of WT MCs. Prss31-null mice had increased baseline airway reactivity to methacholine but markedly reduced experimental chronic obstructive pulmonary disease and colitis, thereby indicating both beneficial and adverse functional roles for the tryptase. In a cigarette smokeinduced model of chronic obstructive pulmonary disease, WT mice had more pulmonary macrophages, higher histopathology scores, and more fibrosis in their small airways than similarly treated Prss31-null mice. In a dextran sodium sulfate-induced acute colitis model, WT mice lost more weight, had higher histopathology scores, and contained more Cxcl-2 and IL-6 mRNA in their colons than similarly treated Prss31-null mice. The accumulated data raise the possibility that inhibitors of this membrane tryptase may provide additional therapeutic benefit in the treatment of humans with these MC-dependent inflammatory diseases. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

DOI 10.1074/jbc.M114.548594
Citations Scopus - 15Web of Science - 13
Co-authors Philip Hansbro, Michael Fricker
2014 Hatchwell L, Girkin J, Morten M, Collison A, Mattes J, Foster PS, et al., 'Salmeterol attenuates chemotactic responses in rhinovirus-induced exacerbation of allergic airways disease¿by modulating protein phosphatase 2A', Journal of Allergy and Clinical Immunology, (2014) [C1]

Background: ß-Agonists are used for relief and control of asthma symptoms by reversing bronchoconstriction. They might also have anti-inflammatory properties, but the underpinnin... [more]

Background: ß-Agonists are used for relief and control of asthma symptoms by reversing bronchoconstriction. They might also have anti-inflammatory properties, but the underpinning mechanisms remain poorly understood. Recently, a direct interaction between formoterol and protein phosphatase 2A (PP2A) has been described in¿vitro. Objective: We sought to elucidate the molecular mechanisms by which ß-agonists exert anti-inflammatory effects in allergen-driven and rhinovirus 1B-exacerbated allergic airways disease (AAD). Methods: Mice were sensitized and then challenged with house dust mite to induce AAD while receiving treatment with salmeterol, formoterol, or salbutamol. Mice were also infected with rhinovirus 1B to exacerbate lung inflammation and therapeutically administered salmeterol, dexamethasone, or the PP2A-activating drug (S)-2-amino-4-(4-[heptyloxy]phenyl)-2-methylbutan-1-ol (AAL[S]). Results: Systemic or intranasal administration of salmeterol protected against the development of allergen- and rhinovirus-induced airway hyperreactivity and decreased eosinophil recruitment to the lungs as effectively as dexamethasone. Formoterol and salbutamol also showed anti-inflammatory properties. Salmeterol, but not dexamethasone, increased PP2A activity, which reduced CCL11, CCL20, and CXCL2 expression and reduced levels of phosphorylated extracellular signal-regulated kinase 1 and active nuclear factor ¿B subunits in the lungs. The anti-inflammatory effect of salmeterol was blocked by targeting the catalytic subunit of PP2A with small RNA interference. Conversely, increasing PP2A activity with AAL(S) abolished rhinovirus-induced airway hyperreactivity, eosinophil influx, and CCL11, CCL20, and CXCL2 expression. Salmeterol also directly activated immunoprecipitated PP2A in¿vitro isolated from human airway epithelial cells. Conclusions: Salmeterol exerts anti-inflammatory effects by increasing PP2A activity in AAD and rhinovirus-induced lung inflammation, which might potentially account for some of its clinical benefits. © 2013 American Academy of Allergy, Asthma & Immunology.

DOI 10.1016/j.jaci.2013.11.014
Citations Scopus - 13Web of Science - 11
Co-authors Matt Dun, Nikki Verrills, Joerg Mattes
2014 Tay HL, Plank M, Collison A, Mattes J, Kumar RK, Foster PS, 'MicroRNA: Potential biomarkers and therapeutic targets for allergic asthma?', Annals of Medicine, 46 633-639 (2014) [C1]

© 2014 Informa UK, Ltd.MicroRNAs are small non-coding RNAs that bind to multiple target mRNAs to control gene expression post-transcriptionally by inhibiting translation. In mamm... [more]

© 2014 Informa UK, Ltd.MicroRNAs are small non-coding RNAs that bind to multiple target mRNAs to control gene expression post-transcriptionally by inhibiting translation. In mammalian cells, microRNAs play important roles in a diverse array of cellular processes (e.g. cell proliferation and differentiation). However, alterations in their levels may compromise cellular function, predisposing to disease. In this review, we discuss microRNAs that have been linked with pathogenesis of asthma and propose functional roles in the regulation of disease. MicroRNAs have the potential to be biomarkers for asthma and provide the platform for the development of new classes of therapeutic compounds.

DOI 10.3109/07853890.2014.958196
Citations Scopus - 6Web of Science - 6
Co-authors Joerg Mattes
2014 Kumar RK, Foster PS, Rosenberg HF, 'Respiratory viral infection, epithelial cytokines, and innate lymphoid cells in asthma exacerbations', Journal of Leukocyte Biology, 96 391-396 (2014) [C1]

Exacerbations of asthma are most commonly triggered by viral infections, which amplify allergic inflammation. Cytokines released by virus-infected AECs may be important in driving... [more]

Exacerbations of asthma are most commonly triggered by viral infections, which amplify allergic inflammation. Cytokines released by virus-infected AECs may be important in driving this response. This review focuses on accumulating evidence in support of a role for epithelial cy-tokines, including IL-33, IL-25, and TSLP, as well as their targets, type 2 innate lymphoid cells (ILC2s), in the patho-genesis of virus-induced asthma exacerbations. Production and release of these cytokines lead to recruitment and activation of ILC2s, which secrete mediators, including IL-5 and IL-13, which augment allergic inflammation. However, little information is currently available about the induction of these responses by the respiratory viruses that are strongly associated with exacerbations of asthma, such as rhinoviruses. Further human studies, as well as improved animal experimental models, are needed to investigate appropriately the pathogenetic mechanisms in virus-induced exacerbations of asthma, including the role of ILCs. © Society for Leukocyte Biology.

DOI 10.1189/jlb.3RI0314-129R
Citations Scopus - 10Web of Science - 8
2014 Collison A, Li J, Pereira De Siqueira A, Zhang J, Toop HD, Morris JC, et al., 'Tumor necrosis factor-related apoptosis-inducing ligand regulates hallmark features of airways remodeling in allergic airways disease', American Journal of Respiratory Cell and Molecular Biology, 51 86-93 (2014) [C1]

Allergic asthma is a complex disease characterized by acute inflammation of the airways that over time leads to the development of significant structural changes termed remodeling... [more]

Allergic asthma is a complex disease characterized by acute inflammation of the airways that over time leads to the development of significant structural changes termed remodeling. TNF-related apoptosis-inducing ligand (TRAIL) has an important regulatory role in acute allergic airways inflammation through up-regulation of the E3 ubiquitin ligase Midline-1 (MID-1), which limits protein phosphatase 2A (PP2A) activity and downstream dephosphorylation of proinflammatory signaling molecules. The relevance of TRAIL in the development of airways remodeling has yet to be determined. In this study, the lungs of wild-type (WT) BALB/c and Tnfsf10 knockout (TRAIL-/-) mice were chronically exposed to ovalbumin (OVA) for 12 weeks to induce hallmark features of chronic allergic airways disease, including airways hyperreactivity (AHR), subepithelial collagen deposition, goblet cell hyperplasia, and smooth muscle hypertrophy. TRAIL-/- mice were largely protected from the development of AHR and peribronchial eosinophilia and had reduced levels of mast cells in the airways. This correlated with lower levels of cytokines, including IL-4, -5, -10, and -13, and with lower levels of proinflammatory chemokines from cultured cells isolated from the draining lymph nodes. TRAIL-/- mice were also protected from the characteristic features of airways remodeling, including peribronchial fibrosis, smooth muscle hypertrophy, and mucus hypersecretion, which correlated with reduced TGF-ß1 levels in the lungs. MID-1 expression was reduced in TRAIL-/- mice and up-regulated in allergic WT mice. Raising PP2A activity using 2-amino-4-(4-heptyloyphenol)-2-methylbutan-1-ol in allergic WT mice reduced eosinophilia, TGF-ß1, and peribronchial fibrosis. This study shows that TRAIL promotes airways remodeling in an OVA-induced model of chronic allergic airways disease. Targeting TRAIL and its downstream proin flammatory signaling pathway involving PP2A may be of therapeutic bene fit in reducing the hallmark features of airways remodeling observed in chronic allergic airways inflammation. Copyright © 2014 by the American Thoracic Society.

DOI 10.1165/rcmb.2013-0490OC
Citations Scopus - 9Web of Science - 9
Co-authors Joerg Mattes
2013 Eftekhari P, Hajizadeh S, Reza Raoufy M, Reza Masjedi M, Yang M, Hansbro N, et al., 'Preventive effect of N-acetylcysteine in a mouse model of steroid resistant acute exacerbation of asthma', EXCLI Journal, 12 184-192 (2013) [C1]

Oxidative stress appears to have an important role in glucocorticoid insensitivity, as a crucial problem in asthma therapy. We studied the preventive effect of antioxidant N-acety... [more]

Oxidative stress appears to have an important role in glucocorticoid insensitivity, as a crucial problem in asthma therapy. We studied the preventive effect of antioxidant N-acetylcysteine (NAC) on the airway hyper-responsiveness (AHR) and the accumulation of inflammatory cells in the airways in an animal model of steroid resistant acute exacerbation of asthma. Systemically sensitized Balb/C mice were exposed to Ovalbumin aerosol on days 13, 14, 15 and 16, followed by intratracheal lipopolysaccharide (LPS) to induce acute exacerbation. NAC (intraperitoneal, 320 mg/kg 30 min before and 12 hours after each challenge) reduced hyperresponsiveness with/out dexamethasone. LPS application caused neutrophilia in bronchoalveolar lavage fluid (BALF) and eosinophil count was higher than respective control in BALF as well as neutrophils after dexamethasone treatment. NAC significantly decreased neutrophil and eosinophil count in BALF as well as inflammatory cytokines (IL-13 and IL-5).We concluded that addition of NAC to asthma therapy has beneficial preventive effects in an animal model of steroid resistant acute exacerbation of asthma.

Citations Scopus - 1Web of Science - 1
Co-authors Ming Yang, Nicole Hansbro
2013 de Souza Alves CC, Collison A, Hatchwell L, Plank M, Morten M, Foster PS, et al., 'Inhibiting AKT phosphorylation employing non-cytotoxic anthraquinones ameliorates TH2 mediated allergic airways disease and rhinovirus exacerbation.', PLoS One, 8 e79565 (2013) [C1]
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Co-authors Joerg Mattes
2013 Kaiko G, Loh Z, Spann K, Lynch J, Lalwani A, Davidson S, et al., 'TLR7 gene deficiency and early-life pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice', EUROPEAN RESPIRATORY JOURNAL, 42 (2013)
2013 Hansbro P, Beckett E, Stevens R, Jarnicki A, Wark P, Foster P, 'A short-term model of COPD identifies a role for mast cell tryptase', EUROPEAN RESPIRATORY JOURNAL, 42 (2013)
Co-authors Simon Keely, Peter Wark, Jay Horvat, Philip Hansbro
2013 Thorburn AN, Brown AC, Nair PM, Chevalier N, Foster PS, Gibson PG, Hansbro PM, 'Pneumococcal Components Induce Regulatory T Cells That Attenuate the Development of Allergic Airways Disease by Deviating and Suppressing the Immune Response to Allergen', JOURNAL OF IMMUNOLOGY, 191 4112-4120 (2013) [C1]
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Citations Scopus - 6Web of Science - 5
Co-authors Peter Gibson, Philip Hansbro
2013 Kaiko GE, Loh Z, Spann K, Lynch JP, Lalwani A, Zheng Z, et al., 'Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131 1331-U132 (2013) [C1]
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Citations Scopus - 22Web of Science - 21
Co-authors Jodie Simpson, Katherine Baines
2013 Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, et al., 'A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis', The Journal of Allergy and Clinical Immunology, 131 752-762 (2013) [C1]
Citations Scopus - 50Web of Science - 50
Co-authors Philip Hansbro, Nicole Hansbro, Simon Keely, Jay Horvat, Peter Wark, Ming Yang
2013 Foster PS, Plank MW, Collison AM, Tay HL, Kaiko GE, Li J, et al., 'The emerging role of microRNAs in regulating immune and inflammatory responses in the lung', Immunological Reviews, 253 198-215 (2013) [C1]
Citations Scopus - 21Web of Science - 22
Co-authors Joerg Mattes, Ming Yang, Philip Hansbro
2013 Barry J, Loh Z, Collison A, Mazzone S, Lalwani A, Zhang V, et al., 'Absence of Toll-IL-1 Receptor 8/Single Immunoglobulin IL-1 Receptor-Related Molecule Reduces House Dust Mite-Induced Allergic Airway Inflammation in Mice', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 49 481-490 (2013) [C1]
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Citations Scopus - 7Web of Science - 6
Co-authors Joerg Mattes
2013 Collison AM, Hatchwell LM, Verrills NM, Wark PA, Pereira De Siqueira AL, Tooze MK, et al., 'The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity', Nature Medicine, 19 232-237 (2013) [C1]
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Co-authors Joerg Mattes, Nathan Bartlett, Peter Wark, Nikki Verrills
2013 Hansbro PM, Scott GV, Essilfie A-T, Kim RY, Starkey MR, Nguyen D, et al., 'Th2 cytokine antagonists: Potential treatments for severe asthma', Expert Opinion on Investigational Drugs, 22 49-69 (2013) [C1]
Citations Scopus - 22Web of Science - 16
Co-authors Malcolm Starkey, Ming Yang, Philip Hansbro, Jay Horvat
2013 Starkey MR, Jarnicki AG, Essilfie A-T, Gellatly SL, Kim RY, Brown AC, et al., 'Murine models of infectious exacerbations of airway inflammation', CURRENT OPINION IN PHARMACOLOGY, 13 337-344 (2013) [C1]
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Citations Scopus - 15Web of Science - 13
Co-authors Philip Hansbro, Jay Horvat, Malcolm Starkey
2013 Rosenberg HF, Dyer KD, Foster PS, 'Eosinophils: changing perspectives in health and disease', NATURE REVIEWS IMMUNOLOGY, 13 9-22 (2013) [C1]
DOI 10.1038/nri3341
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2013 Rosenberg HF, Foster PS, 'Eosinophil cytolysis and release of cell-free granules', NATURE REVIEWS IMMUNOLOGY, 13 (2013) [C3]
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Citations Scopus - 1
2013 Collison A, Siegle JS, Hansbro NG, Kwok C-T, Herbert C, Mattes J, et al., 'Epigenetic changes associated with disease progression in a mouse model of childhood allergic asthma', DISEASE MODELS & MECHANISMS, 6 993-1000 (2013) [C1]
DOI 10.1242/dmm.011247
Citations Scopus - 5Web of Science - 4
Co-authors Joerg Mattes, Nicole Hansbro
2013 Herbert C, Siegle JS, Shadie AM, Nikolaysen S, Garthwaite L, Hansbro NG, et al., 'Development of asthmatic inflammation in mice following early-life exposure to ambient environmental particulates and chronic allergen challenge', DMM Disease Models and Mechanisms, 6 479-488 (2013) [C1]
Citations Scopus - 10Web of Science - 10
Co-authors Nicole Hansbro
2013 Li JJ, Tay HL, Plank M, Essilfie A-T, Hansbro PM, Foster PS, Yang M, 'Activation of Olfactory Receptors on Mouse Pulmonary Macrophages Promotes Monocyte Chemotactic Protein-1 Production', PLOS ONE, 8 (2013) [C1]
DOI 10.1371/journal.pone.0080148
Citations Scopus - 2Web of Science - 2
Co-authors Philip Hansbro, Ming Yang
2013 Starkey MR, Essilfie A-T, Horvat JC, Kim RY, Nguyen DH, Beagley KW, et al., 'Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease', Mucosal Immunology, 6 569-579 (2013) [C1]
Citations Scopus - 12Web of Science - 8
Co-authors Malcolm Starkey, Joerg Mattes, Jay Horvat, Philip Hansbro
2012 Thorburn AN, Foster PS, Gibson PG, Hansbro PM, 'Components of streptococcus pneumoniae suppress allergic airways disease and NKT cells by inducing regulatory T cells', The Journal of Immunology, 188 4611-4620 (2012) [C1]
Citations Scopus - 29Web of Science - 26
Co-authors Peter Gibson, Philip Hansbro
2012 Essilfie A-T, Simpson JL, Dunkley ML, Morgan LC, Oliver BG, Gibson PG, et al., 'Combined haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma', Thorax, 67 588-599 (2012) [C1]
Citations Scopus - 44Web of Science - 38
Co-authors Peter Gibson, Margaret Dunkley, Philip Hansbro, Jodie Simpson
2012 Munitz A, Foster PS, 'T(H)9 cells: In front and beyond T(H)2', Journal of Allergy and Clinical Immunology, 129 1011-1013 (2012) [C3]
Citations Scopus - 2Web of Science - 2
2012 Yang M, Kumar RK, Hansbro PM, Foster PS, 'Emerging roles of pulmonary macrophages in driving the development of severe asthma', Journal of Leukocyte Biology, 91 557-569 (2012) [C1]
Citations Scopus - 36Web of Science - 35
Co-authors Ming Yang, Philip Hansbro
2012 Kumar RK, Foster PS, 'Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?', Frontiers in Physiology, 3 1-7 (2012) [C1]
DOI 10.3389/fphys.2012.00312
Citations Scopus - 16Web of Science - 10
2012 Kumar RK, Yang M, Herbert C, Foster PS, 'Interferon-¿, pulmonary macrophages and airway responsiveness in asthma', Inflammation and Allergy - Drug Targets, 11 292-297 (2012) [C1]
Citations Scopus - 10
Co-authors Ming Yang
2012 Beckett EL, Phipps S, Starkey MR, Horvat JC, Beagley KW, Foster PS, Hansbro PM, 'TLR2, but not TLR4, is required for effective host defence against chlamydia respiratory tract infection in early life', PLOS One, 7 e39460 (2012) [C1]
Citations Scopus - 25Web of Science - 20
Co-authors Malcolm Starkey, Philip Hansbro, Jay Horvat
2012 Hansbro PM, Starkey MR, Kim RY, Stevens RL, Foster PS, Horvat JC, 'Programming of the lung by early-life infection', Journal of Developmental Origins of Health and Disease, 3 153-158 (2012) [C1]
Citations Scopus - 7Web of Science - 5
Co-authors Jay Horvat, Philip Hansbro, Malcolm Starkey
2011 Collison AM, Herbert C, Siegle JS, Mattes J, Foster PS, Kumar RK, 'Altered expression of microRNA in the airway wall in chronic asthma: miR-126 as a potential therapeutic target', BMC Pulmonary Medicine, 11 29 (2011) [C1]
Citations Scopus - 55Web of Science - 51
Co-authors Joerg Mattes
2011 Kaiko GE, Foster PS, 'New insights into the generation of Th2 immunity and potential therapeutic targets for the treatment of asthma', Current Opinion in Allergy and Clinical Immunology, 11 39-45 (2011) [C1]
DOI 10.1097/aci.0b013e328342322f
Citations Scopus - 29Web of Science - 28
2011 Essilfie A-T, Simpson JL, Horvat JC, Preston JA, Dunkley ML, Foster PS, et al., 'Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease', PLoS Pathogens, 7 e1002244 (2011) [C1]
Co-authors Peter Gibson, Jay Horvat, Jodie Simpson, Philip Hansbro, Margaret Dunkley
2011 Asquith KL, Horvat JC, Kaiko GE, Carey AJ, Beagley KW, Hansbro PM, Foster PS, 'Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts', PLoS Pathogens, 7 e1001339 (2011) [C1]
Citations Scopus - 30Web of Science - 26
Co-authors Jay Horvat, Philip Hansbro
2011 Wang W, Hansbro PM, Foster PS, Yang M, 'An alternate STAT6-independent pathway promotes eosinophil influx into blood during allergic airway inflammation', PLoS ONE, 6 e17766 (2011) [C1]
DOI 10.1371/journal.pone.0017766
Citations Scopus - 7Web of Science - 6
Co-authors Philip Hansbro, Ming Yang
2011 Hansbro PM, Kaiko GE, Foster PS, 'Cytokine/anti-cytokine therapy - Novel treatments for asthma?', British Journal of Pharmacology, 163 81-95 (2011) [C2]
DOI 10.1111/j.1476-5381.2011.01219.x
Citations Scopus - 64Web of Science - 54
Co-authors Philip Hansbro
2011 Siegle JS, Hansbro NG, Dong C, Angkasekwinai P, Foster PS, Kumar RK, 'Blocking induction of T helper type 2 responses prevents development of disease in a model of childhood asthma', Clinical and Experimental Immunology, 165 19-28 (2011) [C1]
DOI 10.1111/j.1365-2249.2011.04392.x
Citations Scopus - 20Web of Science - 20
Co-authors Nicole Hansbro
2011 Wu D, Ahrens R, Osterfeld H, Noah TK, Groschwitz K, Foster PS, et al., 'Interleukin-13 (IL-13)/IL-13 receptor1 (IL-13R1) signaling regulates intestinal epithelial cystic fibrosis transmembrane conductance regulator channel-dependent Cl- secretion', Journal of Biological Chemistry, 286 13357-13369 (2011) [C1]
Citations Scopus - 22Web of Science - 18
2011 Davidson SK, Kaiko GE, Loh Z, Lalwani A, Zhang V, Spann K, et al., 'Plasmacytoid Dendritic Cells promote host defense against Acute Pneumovirus infection via the TLR7-MyD88-Dependent signaling pathway', Journal of Immunology, 186 5938-5948 (2011) [C1]
DOI 10.4049/jimmunol.1002635
Citations Scopus - 39Web of Science - 38
Co-authors Nicole Hansbro
2011 Lousberg EL, Diener KR, Fraser CK, Phipps S, Foster PS, Chen W, et al., 'Antigen-specific T-Cell responses to a recombinant fowlpox virus are dependent on MyD88 and Interleukin-18 and Independent of Toll-Like Receptor 7 (TLR7)- and TLR9-Mediated innate immune recognition', Journal of Virology, 85 3385-3396 (2011) [C1]
DOI 10.1128/jvi.02000-10
Citations Scopus - 6Web of Science - 6
2011 Collison AM, Mattes J, Plank MW, Foster PS, 'Inhibition of house dust mite-induced allergic airways disease by antagonism of microRNA-145 is comparable to glucocorticoid treatment', Journal of Allergy and Clinical Immunology, 128 160-U251 (2011) [C1]
Citations Scopus - 95Web of Science - 79
Co-authors Joerg Mattes
2011 Preston JA, Thorburn AN, Starkey MR, Beckett EL, Horvat JC, Wade MA, et al., 'Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells', European Respiratory Journal, 37 53-64 (2011) [C1]
DOI 10.1183/09031936.00049510
Citations Scopus - 37Web of Science - 33
Co-authors Philip Hansbro, Peter Gibson, Jay Horvat, Malcolm Starkey
2011 Hazlewood LC, Wood LG, Hansbro PM, Foster PS, 'Dietary lycopene supplementation suppresses Th2 responses and lung eosinophilia in a mouse model of allergic asthma', Journal of Nutritional Biochemistry, 22 95-100 (2011) [C1]
DOI 10.1016/j.jnutbio.2009.12.003
Citations Scopus - 20Web of Science - 15
Co-authors Philip Hansbro, Lisa Wood
2010 Lau JY, Oliver BG, Baraket M, Beckett EL, Hansbro NG, Moir LM, et al., 'Fibulin-1 Is increased in asthma - A novel mediator of airway remodeling?', Plos One, 5 1-13 (2010) [C1]
DOI 10.1371/journal.pone.0013360
Citations Scopus - 19Web of Science - 16
Co-authors Philip Hansbro, Nicole Hansbro
2010 Herbert C, Scott MM, Scruton KH, Keogh RP, Yuan KC, Hsu K, et al., 'Alveolar macrophages stimulate enhanced cytokine production by pulmonary CD4+ T-lymphocytes in an exacerbation of murine chronic asthma', American Journal of Pathology, 177 1657-1664 (2010) [C1]
DOI 10.2353/ajpath.2010.100019
Citations Scopus - 23Web of Science - 20
2010 Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, et al., 'Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease', Journal of Immunology, 184 4159-4169 (2010) [C1]
DOI 10.4049/jimmunol.0902287
Citations Scopus - 45Web of Science - 41
Co-authors Jay Horvat, Peter Gibson, Philip Hansbro, Malcolm Starkey
2010 Kaiko GE, Phipps S, Angkasekwinai P, Dong C, Foster PS, 'NK cell deficiency predisposes to viral-induced Th2-type allergic inflammation via epithelial-derived IL-25', Journal of Immunology, 185 4681-4690 (2010) [C1]
DOI 10.4049/jimmunol.1001758
Citations Scopus - 57Web of Science - 50
2010 Li J, Wang W, Baines KJ, Bowden NA, Hansbro PM, Gibson PG, et al., 'IL-27/IFN-y induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages', Journal of Immunology, 185 4401-4409 (2010) [C1]
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Citations Scopus - 47Web of Science - 42
Co-authors Katherine Baines, Nikola Bowden, Ming Yang, Philip Hansbro, Peter Gibson
2010 Thorburn AN, O'Sullivan BJ, Thomas R, Kumar RK, Foster PS, Gibson PG, Hansbro PM, 'Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease', Thorax, 65 1053-1060 (2010) [C1]
DOI 10.1136/thx.2009.131508
Citations Scopus - 32Web of Science - 31
Co-authors Philip Hansbro, Peter Gibson
2010 Horvat JC, Starkey MR, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Journal of Allergy and Clinical Immunology, 125 617-625 (2010) [C1]
DOI 10.1016/j.jaci.2009.10.018
Co-authors Malcolm Starkey, Jay Horvat, Peter Gibson, Philip Hansbro
2010 Hutchinson MR, Loram LC, Zhang Y, Shridhar M, Rezvani N, Berkelhammer D, et al., 'Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity', Neuroscience, 168 551-563 (2010) [C1]
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2010 Yang M, Kumar RK, Foster PS, 'Interferon-Y and pulmonary macrophages contribute to the mechanisms underlying prolonged airway hyperresponsiveness', Clinical and Experimental Allergy, 40 163-173 (2010) [C1]
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Citations Scopus - 22Web of Science - 17
Co-authors Ming Yang
2010 Wood LG, Hazlewood LC, Foster PS, Hansbro PM, 'Lyprinol reduces inflammation and improves lung function in a mouse model of allergic airways disease', Clinical and Experimental Allergy, 40 1785-1793 (2010) [C1]
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Citations Scopus - 12Web of Science - 11
Co-authors Philip Hansbro, Lisa Wood
2010 Burgess JK, Boustany S, Moir LM, Weckmann M, Lau JY, Grafton K, et al., 'Reduction of tumstatin in asthmatic airways contributes to angiogenesis, inflammation, and hyperresponsiveness', American Journal of Respiratory and Critical Care Medicine, 181 106-115 (2010) [C1]
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Co-authors Philip Hansbro, Nicole Hansbro
2010 Wang W, Li J, Foster PS, Hansbro PM, Yang M, 'Potential therapeutic targets for steroid-resistant asthma', Current Drug Targets, 11 957-970 (2010) [C1]
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Co-authors Ming Yang, Philip Hansbro
2010 Siegle JS, Hansbro NG, Herbert C, Rosenberg HF, Domachowske JB, Asquith KL, et al., 'Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice', Respiratory Research, 11 1-15 (2010) [C1]
DOI 10.1186/1465-9921-11-14
Citations Scopus - 47Web of Science - 43
Co-authors Nicole Hansbro
2009 Kumar RK, Hitchins MP, Foster PS, 'Epigenetic changes in childhood asthma', Disease Models and Mechanisms: DMM, 2 549-553 (2009) [C1]
DOI 10.1242/dmm.001719
Citations Scopus - 19Web of Science - 13
2009 De Vries A, Hazlewood LC, Fitch PM, Seckl JR, Foster PS, Howie SEM, 'High-fat feeding redirects cytokine responses and decreases allergic airway eosinophilia', Clinical & Experimental Allergy, 39 731-739 (2009) [C1]
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Citations Scopus - 23Web of Science - 23
2009 Yang M, Kumar RK, Foster PS, 'Pathogenesis of steroid-resistant airway hyperresponsiveness: Interaction between IFN-gamma and TLR4/MyD88 pathways', Journal of Immunology, 182 5107-5115 (2009) [C1]
DOI 10.4049/jimmunol.0803468
Citations Scopus - 45Web of Science - 37
Co-authors Ming Yang
2009 Percopo CM, Qiu Z, Phipps S, Foster PS, Domachowske JB, Rosenberg HF, 'Pulmonary eosinophils and their role in immunopathologic responses to formalin-inactivated pneumonia virus of mice', Journal of Immunology, 183 604-612 (2009) [C1]
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Citations Scopus - 16Web of Science - 13
2009 Cai Y, Kumar RK, Zhou J, Foster PS, Webb DC, 'Ym1/2 promotes Th2 cytokine expression by inhibiting 12/15(S)-lipoxygenase: Identification of a novel pathway for regulating allergic inflammation', Journal of Immunology, 182 5393-5399 (2009) [C1]
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2009 Mattes J, Collison AM, Plank MW, Phipps S, Foster PS, 'Antagonism of microRNA-126 suppresses the effector function of T(H)2 cells and the development of allergic airways disease', Proceedings of the National Academy of Sciences of the United States of America, 106 18704-18709 (2009) [C1]
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Co-authors Joerg Mattes
2009 Knott ML, Matthaei KI, Foster PS, Dent LA, 'The roles of eotaxin and the STAT6 signalling pathway in eosinophil recruitment and host resistance to the nematodes Nippostrongylus brasiliensis and Heligmosomoides bakeri', Molecular Immunology, 46 2714-2722 (2009) [C1]
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2009 Collison AM, Foster PS, Mattes J, 'Emerging role of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) as a key regulator of inflammatory responses', Clinical and Experimental Pharmacology and Physiology, 36 1049-1053 (2009) [C1]
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Co-authors Joerg Mattes
2009 Bertram CM, Misso NL, Fogel-Petrovic M, Figueroa CD, Foster PS, Thompson PJ, Bhoola KD, 'Expression of kinin receptors on eosinophils: Comparison of asthmatic patients and healthy subjects', Journal of Leukocyte Biology, 85 544-552 (2009) [C1]
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2009 Foster PS, Mattes J, 'IL-21 comes of age', Immunology and Cell Biology, 87 359-360 (2009) [C2]
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Co-authors Joerg Mattes
2009 Phipps S, Hansbro NG, Lam CE, Foo A, Matthaei KI, Foster PS, 'Allergic sensitization is enhanced in early life through toll-like receptor 7 activation', Clinical and Experimental Allergy, 39 1920-1928 (2009) [C1]
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Citations Scopus - 10Web of Science - 9
Co-authors Nicole Hansbro
2009 Phipps S, Lam CE, Kaiko GE, Foo A, Collison AM, Mattes J, et al., 'Toll/IL-1 signaling is critical for house dust mite-specific Th1 and Th2 responses', American Journal of Respiratory and Critical Care Medicine, 179 883-893 (2009) [C1]
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Citations Scopus - 102Web of Science - 99
Co-authors Joerg Mattes
2008 Ito K, Herbert C, Siegle JS, Vuppusetty C, Hansbro NG, Thomas PS, et al., 'Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma', American Journal of Respiratory Cell and Molecular Biology, 39 543-550 (2008) [C1]
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Co-authors Nicole Hansbro
2008 Zhou J, Wolf CR, Henderson CJ, Cai Y, Board PG, Foster PS, Webb DC, 'Glutathione transferase P1: An endogenous inhibitor of allergic responses in a mouse model of asthma', American Journal of Respiratory and Critical Care Medicine, 178 1202-1210 (2008) [C1]
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2008 Mattes J, Collison AM, Foster PS, 'Emerging role of microRNAs in disease pathogenesis and strategies for therapeutic modulation', Current Opinion in Molecular Therapeutics, 10 150-157 (2008) [C1]
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Co-authors Joerg Mattes
2008 Foster PS, Rosenberg HF, Asquith KL, Kumar RK, 'Targeting eosinophils in asthma', Current Molecular Medicine, 8 585-590 (2008) [C1]
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2008 Forbes EE, Groschwitz K, Abonia JP, Brandt EB, Cohen E, Blanchard C, et al., 'IL-9-and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity', Journal of Experimental Medicine, 205 897-913 (2008) [C1]
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2008 Gantier MP, Tong S, Behlke MA, Xu D, Phipps S, Foster PS, Williams BRG, 'TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages', Journal of Immunology, 180 2117-2124 (2008) [C1]
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2008 Kaiko GE, Phipps S, Hickey DK, Lam CE, Hansbro PM, Foster PS, Beagley KW, 'Chlamydia muridarum infection subverts dendritic cell function to promote Th2 immunity and airways hyperreactivity', Journal of Immunology, 180 2225-2232 (2008) [C1]
Citations Scopus - 33Web of Science - 32
Co-authors Philip Hansbro
2008 Asquith KL, Ramshaw HS, Hansbro PM, Beagley KW, Lopez AF, Foster PS, 'The IL-3/IL-5/GM-CSF common beta receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammation', Journal of Immunology, 180 1199-1206 (2008) [C1]
Citations Scopus - 66Web of Science - 62
Co-authors Philip Hansbro
2008 Herbert C, Hettiaratchi A, Webb DC, Thomas PS, Foster PS, Kumar RK, 'Suppression of cytokine expression by roflumilast and dexamethasone in a model of chronic asthma', Clinical and Experimental Allergy, 38 847-856 (2008) [C1]
DOI 10.1111/j.1365-2222.2008.02950.x
Citations Scopus - 41Web of Science - 35
2007 Tumes DJ, Cormie J, Calvert MG, Stewart K, Nassenstein C, Braun A, et al., 'Strain-dependent resistance to allergen-induced lung pathophysiology in mice correlates with rate of apoptosis of lung-derived eosinophils', Journal of Leukocyte Biology, 81 1362-1373 (2007) [C1]
DOI 10.1189/jlb.0106046
Citations Scopus - 21Web of Science - 21
2007 Bertram CM, Baltic S, Misso NL, Bhoola KD, Foster PS, Thompson PJ, Fogel-Petrovic M, 'Expression of kinin B1 and B2 receptors in immature, monocyte-derived dendritic cells and bradykinin-mediated increase in intracellular Ca2+ and cell migration', Journal of Leukocyte Biology, 81 1445-1454 (2007) [C1]
DOI 10.1189/jlb.0106055
Citations Scopus - 30Web of Science - 28
2007 Phipps S, Lam CE, Foster PS, Matthaei KI, 'The contribution of toll-like receptors to the pathogenesis of asthma', Immunology and Cell Biology, 85 463-470 (2007) [C1]
DOI 10.1038/sj.icb.7100104
Citations Scopus - 27Web of Science - 25
2007 Mattes J, Yang M, Foster PS, 'Regulation of microRNA by antagomirs: a new class of pharmacological antagonists for the specific regulation of gene function?', American Journal of Respiratory and Cellular Molecular Biology, 36 8-12 (2007) [C1]
DOI 10.1165/rcmb.2006-0227TR
Citations Scopus - 46Web of Science - 40
Co-authors Joerg Mattes, Ming Yang
2007 Horvat JC, Beagley KW, Wade MA, Preston JA, Hansbro NG, Hickey DK, et al., 'Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease', American Journal of Respiratory and Critical Care Medicine, 176 556-564 (2007) [C1]
DOI 10.1164/rccm.200607-1005OC
Citations Scopus - 51Web of Science - 48
Co-authors Jay Horvat, Peter Gibson, Nicole Hansbro, Philip Hansbro
2007 Weckmann M, Collison A, Simpson JL, Kopp MV, Wark PA, Smyth MJ, et al., 'Critical link between TRAIL and CCL20 for the activation of T(H)2 cells and the expression of allergic airway disease', Nature Medicine, 13 1308-1315 (2007) [C1]
DOI 10.1038/nm1660
Citations Scopus - 70Web of Science - 67
Co-authors Peter Wark, Nicole Hansbro, Jodie Simpson, Joerg Mattes, Peter Gibson
2007 Fogel-Petrovic M, Long JA, Misso NL, Foster PS, Bhoola KD, Thompson PJ, 'Physiological concentrations of transforming growth factor Beta1 selectively inhibit human dendritic cell function', International Immunopharmacology, 7 1924-1933 (2007) [C1]
DOI 10.1016/j.intimp.2007.07.003
Citations Scopus - 28Web of Science - 24
2007 Phipps S, Lam CE, Mahalingam S, Newhouse M, Ramirez R, Rosenberg HF, et al., 'Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virus', Blood, 110 1578-1586 (2007) [C1]
DOI 10.1182/blood-2007-01-071340
Citations Scopus - 116Web of Science - 106
2007 Knott ML, Matthaei KI, Giacomin PR, Wang H, Foster PS, Dent LA, 'Impaired resistance in early secondary Nippostrongylus brasiliensis infections in mice with defective eosinophilopoeisis', International Journal for Parasitology, 37 1367-1378 (2007) [C1]
DOI 10.1016/j.ijpara.2007.04.006
Citations Scopus - 44Web of Science - 43
2007 Simson L, Ellyard JI, Dent LA, Matthaei KI, Rothenberg ME, Foster PS, et al., 'Regulation of carcinogenesis by IL-5 and CCL11: A potential role for eosinophils in tumor immune surveillance', JOURNAL OF IMMUNOLOGY, 178 4222-4229 (2007)
Citations Scopus - 81Web of Science - 75
2007 Webb DC, Yang M, Matthaei (Ext) K, Foster PS, 'Comparative roles of IL-4, IL-13, and IL-4Ralpha in dendritic cell maturation and CD4+ Th2 cell function', Journal of Immunology, 178 219-227 (2007) [C1]
Citations Scopus - 46Web of Science - 44
Co-authors Ming Yang
2007 Dyer KD, Czapiga M, Foster B, Foster PS, Kang EM, Lappas CM, et al., 'Eosinophils from lineage-ablated Delta dblGATA bone marrow progenitors: The dblGATA enhancer in the promoter of GATA-1 is not essential for differentiation ex vivo', Journal of Immunology, 179 1693-1699 (2007) [C1]
Citations Scopus - 19Web of Science - 20
2007 Rosenberg HF, Phipps S, Foster PS, 'Eosinophil trafficking in allergy and asthma', Journal of Allergy and Clinical Immunology, 119 1303-1310 (2007) [C1]
DOI 10.1016/j.jaci.2007.03.048
Citations Scopus - 192Web of Science - 177
2007 Preston JA, Essilfie AT, Horvat JC, Wade MA, Beagley KW, Gibson PG, et al., 'Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae', Vaccine, 25 8154-8162 (2007) [C1]
DOI 10.1016/j.vaccine.2007.09.034
Citations Scopus - 30Web of Science - 29
Co-authors Philip Hansbro, Peter Gibson, Jay Horvat
2006 Yang M, Rangasamy D, Matthaei KI, Frew AJ, Zimmmermann N, Mahalingam S, et al., 'Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness', Journal of Immunology, 177 5595-5603 (2006) [C1]
DOI 10.4049/jimmunol.177.8.5595
Citations Scopus - 77Web of Science - 68
Co-authors Ming Yang
2006 Forbes E, Hulett M, Ahrens R, Wagner N, Smart V, Matthaei (Ext) K, et al., 'ICAM-1-dependent pathways regulate colonic eosinophilic inflammation', Journal of Leukocyte Biology, 80 330-341 (2006) [C1]
DOI 10.1189/jlb.1105643
Citations Scopus - 39Web of Science - 36
2006 Prescott VE, Forbes E, Foster PS, Matthaei (Ext) K, Hogan SP, 'Mechanistic analysis of experimental food allergen-induced cutaneous reactions', Journal of Leukocyte Biology, 80 258-266 (2006) [C1]
DOI 10.1189/jlb.1105637
Citations Scopus - 13Web of Science - 11
2006 Bystrom J, Dyer KD, Ravin S, Naumann N, Stephany DA, Foster PS, et al., 'Interleukin-5 does not influence differential transcription of transmembrane and soluble isoforms of IL-5R alpha in vivo', European Journal of Haematology, 77 181-190 (2006) [C1]
DOI 10.1111/j.1600-0609.2006.00699.x
Citations Scopus - 6Web of Science - 6
2006 Sharkhuu T, Matthaei KI, Forbes E, Mahalingam S, Hogan SP, Hansbro PM, Foster PS, 'Mechanism of interleukin-25 (IL-17E)-induced pulmonary inflammation and airways hyper-reactivity', Clinical and Experimental Allergy, 36 1575-1583 (2006) [C1]
DOI 10.1111/j.1365-2222.2006.02595.x
Citations Scopus - 69Web of Science - 59
Co-authors Philip Hansbro
2006 Yang M, Mattes J, Hansbro PM, Foster PS, 'Employment of microRNA profiles and RNA interference and antagomirs for the characterization and treatment of respiratory disease', Drug Discovery Today: Therapeutic Strategies, 3 325-332 (2006) [C1]
DOI 10.1016/j.ddstr.2006.10.001
Citations Scopus - 5
Co-authors Philip Hansbro, Joerg Mattes, Ming Yang
2006 Yang M, Rangasamy D, Matthaei K, Frew A, Zimmmermann N, Mahalingham S, et al., 'Inhibition of arginase I activity by RNA interference attenuates interleukin-13 induced airways hyperresponsiveness', ACTA PHARMACOLOGICA SINICA, 27 266-266 (2006)
Co-authors Ming Yang
2006 Kumar RK, Webb DC, Herbert C, Foster PS, 'Interferon - as a possible target in chronic asthma', Inflammation and Allergy - Drug Targets, 5 253-256 (2006) [C1]
DOI 10.2174/187152806779010909
Citations Scopus - 45
2006 Siegle JS, Hansbro NG, Herbert C, Yang M, Foster PS, Kumar RK, 'Airway hyperreactivity in exacerbation of chronic asthma is independent of elosinophilic inflammation', American Journal of Respiratory Cell and Molecular Biology, 35 565-570 (2006) [C1]
DOI 10.1165/rcmb.2006-0135OC
Citations Scopus - 43Web of Science - 40
Co-authors Nicole Hansbro, Ming Yang
2006 Swartz JM, Dyer KD, Cheever AW, Ramalingam T, Pesnicak L, Domachowske JB, et al., 'Schistosoma mansoni infection in eosinophil lineage-ablated mice', Blood, 108 2420-2427 (2006) [C1]
DOI 10.1182/blood-2006-04-015933
Citations Scopus - 85Web of Science - 73
2005 Prescott VE, Campbell PM, Moore A, Mattes J, Rothenberg ME, Foster PS, et al., 'Transgenic expression of bean alpha-amylase inhibitor in peas results in altered structure and immunogenicity', Journal of Agricultural and Food Chemistry, 53 9023-9030 (2005) [C1]
DOI 10.1021/jf050594v
Citations Scopus - 111Web of Science - 92
Co-authors Joerg Mattes
2005 Rolph MS, So T, Young T, Laybutt R, Commandeur ZA, Foster PS, et al., 'Control of obesity and glucose homeostasis by Th1/Th2 cytokines', INFLAMMATION RESEARCH, 54 S105-S106 (2005)
2004 Forbes E, Smart V, D'Aprile A, Henry P, Yang M, Matthaei KI, et al., 'T Helper-2 Immunity Regulates Bronchial Hyperresponsiveness in Eosinophil-Associated Gastrointestinal Disease in Mice', Gastroenterology, 127 105-118 (2004) [C1]
DOI 10.1053/j.gastro.2004.03.057
Citations Web of Science - 15
Co-authors Ming Yang
2004 Forbes E, Murase T, Yang M, Matthaei KI, Lee JJ, Lee NA, et al., 'Immunopathogenesis of experimental ulcerative colitis is mediated by eosinophil peroxidase1', J Immunol, 172 5664-5675 (2004) [C1]
Citations Scopus - 90Web of Science - 79
Co-authors Ming Yang
2004 Webb DC, Matthaei KI, Cai Y, McKenzie ANJ, Foster PS, 'Polymorphisms in IL-4Ra correlate with airways hyperreactivity, eosinophilia, and Ym protein expression in allergic IL-13 -/- mice1', J Immunol, 172 1092-1098 (2004) [C1]
Citations Scopus - 28Web of Science - 24
2004 Fulkerson PC, Zimmermann N, Brandt EB, Muntel EE, Doepker MP, Kavanaugh JL, et al., 'Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by INF-g (Mig, CXCL9)', Proceedings of the National Academy of Sciences of the USA, 101 1987-1992 (2004) [C1]
DOI 10.1073/pnas.0308544100
Citations Scopus - 75Web of Science - 70
Co-authors Ming Yang
2004 Clark K, Simson L, Newcombe N, Koskinen AML, Mattes J, Lee NA, et al., 'Eosinophil degranulation in the allergic lung of mice primarily occurs in the airway lumen', Journal of Leukocyte Biology, 75 1001-1009 (2004) [C1]
DOI 10.1189/jlb.0803391
Citations Scopus - 37Web of Science - 34
Co-authors Joerg Mattes
2004 Kumar RK, Herbert C, Foster PS, 'Expression of growth factors by airway epithelial cells in a model of chronic asthma: regulation and relationship to subepithelial fibrosis', Clinical and Experimental Allergy, 34 567-575 (2004) [C1]
DOI 10.1111/j.1365-2222.2004.1917.x
Citations Scopus - 59Web of Science - 55
2004 Leigh R, Ellis R, Wattie JN, Hirota JA, Matthaei KI, Foster PS, et al., 'Type 2 cytokines in the pathogenesis of sustained airway dysfunction and airway remodelling in mice', Am J Resp Crit Care Med, 169 860-867 (2004) [C1]
DOI 10.1164/rccm.200305-706OC
Citations Scopus - 126Web of Science - 123
2004 Kumar RK, Herbert C, Webb DC, Li L, Foster PS, 'Effects of anticytokine therapy in a mouse model of chronic asthma', Am, J Resp Crit Care Med, 170 1043-1048 (2004) [C1]
DOI 10.1164/rccm.200405-681OC
Citations Scopus - 111Web of Science - 97
2004 Hogan SP, Rothenberg ME, Forbes E, Smart VE, Matthaei KI, Foster PS, 'Chemokines in Eosinophil-associated Gastrointestinal Disorders', Current Allergy and Asthma Reports, 4 74-82 (2004) [C1]
DOI 10.1007/s11882-004-0047-8
Citations Scopus - 19Web of Science - 15
2003 Mattes J, Foster P, 'Regulation of eosinophil migration and Th2 cell function by IL-5 and eotaxin', Current Drug Targets, 2 169-174 (2003) [C1]
Citations Scopus - 39
Co-authors Joerg Mattes
2003 Foster PS, Yang M, Mattes J, Kumar R, Webb D, 'Interleukin-13 and allergy', Modern Aspects of Immunobiology, 3 8 (2003)
2003 Matthaei KI, Donaldson DD, Foster PS, Webb DC, Mahalingam S, Cai Y, 'Antigen-specific production of interleukin (IL)-13 and IL-5 cooperate to mediate IL-4R&agr;-independent airway hyperreactivity', European Journal of Immunology, 33 3377-3385 (2003) [C1]
DOI 10.1002/eji.200324178
Citations Scopus - 25Web of Science - 25
2003 Zimmerman N, King NE, Laporte J, Yang M, Mishra A, Pope S, et al., 'Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis', Journal of Clinical Investigation, 111 1863-1874 (2003) [C1]
DOI 10.1172/JCI200317912
Citations Scopus - 390Web of Science - 359
Co-authors Ming Yang
2003 Mattes J, Hulett M, Xie W, Hogan S, Rothenburg ME, Foster P, Parish C, 'Immunotherapy of cytotoxic T cell resistant tumors by T helper 2 cells: an eotaxin and STAT6 dependent process', Journal of Experimental Medicine, 197 387-393 (2003) [C1]
DOI 10.1084/jem.20021683
Citations Scopus - 120Web of Science - 114
Co-authors Joerg Mattes
2003 Smart V, Foster PS, Rothenberg ME, Higgins TJ, Hogan SP, 'A plant-based allergy vaccine suppresses experimental asthma via an IFN-y and CD4+ CD45RB low T cell-dependent mechanism', Journal of Immunology, 171 2116-2126 (2003) [C1]
Citations Scopus - 33Web of Science - 29
2003 Kumar RK, Herbert C, Thomas PS, Wollin L, Beume R, Yang M, et al., 'Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma', Journal of Pharmacology and Experimental Therapeutics, 307 349-355 (2003) [C1]
DOI 10.1124/jpet.103.053819
Citations Scopus - 117Web of Science - 94
Co-authors Ming Yang
2003 Yang M, Hogan SP, Mahalingam S, Pope SM, Zimmermann N, Fulkerson P, et al., 'Eotaxin-2 and 165 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 112 935-943 (2003)
DOI 10.1067/mai.2003.1791
Citations Web of Science - 71
2003 Zimmermann N, Gurjit Khurana H, Foster PS, Rothenberg ME, 'Chemokines in asthma: Cooperative interaction between chemokines and IL-13', Journal of Allergy and Clinical Immunology, 111 227-242 (2003) [C1]
DOI 10.1067/mai.2003.139
Citations Scopus - 224Web of Science - 201
2003 Yang M, Hogan SP, Mahalingam S, Pope SM, Zimmerman N, Fulkerson P, et al., 'Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity', Journal of Allergy and Clinical Immunology, 112 935-943 (2003) [C1]
DOI 10.1016/j.jaci.2003.08.010
Citations Scopus - 79
Co-authors Ming Yang
2003 Kruse S, Kuehr J, Moseler M, Kropp MV, Kurz T, Deichmann KA, et al., 'Polymorphisms in the IL18 gene are associated with specific sensitization to common allergens and allergic rhinitis', Journal of Allergy and Clinical Immunology, 111 117-122 (2003) [C1]
DOI 10.1067/mai.2003.43
Citations Scopus - 98Web of Science - 84
Co-authors Joerg Mattes
2003 Foster PS, Webb DC, Yang M, Herbert C, Kumar RK, 'Dissociation of T helper type 2 cytokine-dependent airway lesions from signal transducer and activator of transcription 6 signalling in experimental chronic asthma', Clinical and Experimental Allergy, 33 688-695 (2003) [C1]
DOI 10.1046/j.1365-2222.2003.01647.x
Citations Scopus - 42Web of Science - 36
Co-authors Ming Yang
2002 Foster PS, Wong G, Yasuda S, Qi J, Mahalingam S, Mellor E, et al., 'Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal transducer and activator of transcription (STAT) 6-dependent pathway', Journal of Biological Chemistry, 277 1906-1915 (2002) [C1]
Citations Scopus - 59Web of Science - 50
2002 Mishra A, Hogan S, Brandt E, Wagner N, Crossman M, Foster PS, Rothenberg M, 'Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking', Journal of Biological Chemistry, 277 4406-4412 (2002) [C1]
Citations Scopus - 62Web of Science - 54
2002 Mattes J, Yang M, Mahalinggam S, Kuehr J, Webb DC, Simson L, et al., 'Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and cotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma.', J Exp Med. 195:1433-44, 1433-1444 (2002) [C1]
Citations Scopus - 194Web of Science - 180
Co-authors Joerg Mattes
2002 Kumar R, Thomas P, Seetoo D-Q, Herbert C, McKenzie A, Foster PS, Lloyd A, 'Eotaxin expression by epithelial cells and plasma cells in chronic asthma', Laboratory Investigation, 82 495-504 (2002) [C1]
Citations Web of Science - 18
2002 Foster PS, Yang M, Herbert C, Kumar R, 'CD4+ T-lymphocytes regulate airway remodeling and hyper-reactivity in a mouse model of chronic asthma', Laboratory Investigation, 82 455-462 (2002) [C1]
Citations Web of Science - 41
2002 Foster PS, Hogan S, Yang M, Mattes J, Young I, Matthaei K, et al., 'Interleukin-5 and eosinophils as therapeutic targets for asthma', Trends in Molecular Medicine, 8 162-167 (2002) [C2]
Citations Scopus - 57Web of Science - 53
Co-authors Joerg Mattes
2002 Foster PS, Martinez-Moczygemba M, Huston D, Corry D, 'Interleukins-4, -5, and -13: emerging therapeutic targets in allergic disease', Pharmacology and Therapeutics, 94 253-264 (2002) [C1]
Citations Scopus - 60Web of Science - 54
2002 Foster PS, Mahalingam S, Meanger J, Lidbury B, 'The viral manipulation of the host cellular and immune environments to enhance propagation and survival: a focus on RNA viruses', Journal of Leukocyte Biology, 72 429-439 (2002) [C2]
Citations Scopus - 35Web of Science - 32
2002 Kumar R, Foster PS, 'ST2: marker, activator and regulator of Th2 immunity?', Clinical and Experimental Allergy, 32 1394-1396 (2002) [C2]
Citations Scopus - 3Web of Science - 3
2002 Kumar R, Herbert C, Yang M, Koskinen A, McKenzie A, Foster PS, 'Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma', Clinical and Experimental Allergy, 32 1104-1111 (2002) [C1]
Citations Scopus - 123Web of Science - 97
2002 Hogan S, Foster PS, Rothenberg M, 'Experimental analysis of eosinophil-associated gastrointestinal diseases', Current Opinion in Allergy and Clinical Immunology, 2 239-248 (2002) [C1]
Citations Scopus - 25Web of Science - 18
2002 Truong-Tran A, Ruffin R, Foster PS, Koskinen A, Coyle P, Philcox J, et al., 'Altered zinc homeostasis and caspase-3 activity in murine allergic airway inflammation', American Journal of Respiratory Cell and Molecular Biology, 27 286-296 (2002) [C1]
Citations Web of Science - 47
2002 Kumar R, Foster PS, 'Modeling allergic asthma in mice: pitfalls and opportunities', American Journal of Respiratory Cell and Molecular Biology, 27 267-272 (2002) [C1]
Citations Web of Science - 138
2001 Webb D, McKenzie A, Foster PS, 'Expression of the Ym2 lectin-binding protein is dependent on interleukin (IL)-4 and IL-13 signal transduction: identification of a novel allergy-associated protein', Journal of Biological Chemistry, 276 1969-1976 (2001) [C1]
Citations Scopus - 121Web of Science - 110
2001 Foster PS, Mahalingam S, Chaudhri G, Tan C, John A, Karupiah G, 'Transcription of the interferon (IFN-gamma)-inducible chemokine Mig in IFN-gamma-deficient Mice', Journal of Biological Chemistry, 276 7568-7574 (2001) [C1]
Citations Scopus - 28Web of Science - 27
2001 Hertz M, Mahalingam S, Dalum I, Klysner S, Mattes J, Neisig A, et al., 'Active vaccination against IL-5 bypasses immunological tolerance and ameliorates experimental asthma', Journal of Immunology, 167 3792-3799 (2001) [C1]
Citations Web of Science - 66
Co-authors Joerg Mattes
2001 Mackenzie J, Mattes J, Dent L, Foster PS, 'Eosinophils promote allergic disease of the lung by regulating CD4+ Th2 lymphocyte function', Journal of Immunology, 167 3146-3155 (2001) [C1]
Citations Scopus - 136Web of Science - 126
Co-authors Joerg Mattes
2001 Mattes J, Yang M, Siqueira A, Clark K, Mackenzie J, McKenzie A, et al., 'IL-13 induces airways hyperreactivity independently of the IL-4R{alpha} chain in the allergic lung', Journal of Immunology, 167 1683-1692 (2001) [C1]
Citations Scopus - 114Web of Science - 104
Co-authors Joerg Mattes
2001 Pope S, Brandt E, Mishra A, Hogan S, Zimmermann N, Matthaei K, et al., 'IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism', Journal of Allergy and Clinical Immunology, 108 594-601 (2001) [C1]
Citations Web of Science - 134
2001 Foster PS, Mould A, Yang M, Mackenzie J, Mattes J, Hogan S, et al., 'Elemental signals regulating eosinophil accumulation in the lung', Immunological Reviews, 179 173-181 (2001) [C2]
Citations Scopus - 165Web of Science - 147
Co-authors Joerg Mattes
2001 Mahalingam S, Clark K, Matthaei K, Foster PS, 'Antiviral potential of chemokines', BioEssays, 23 428-435 (2001) [C2]
Citations Scopus - 14Web of Science - 13
2001 Zuegg J, Webb D, Foster PS, Casarotto M, 'Structural model of human IL-13 defines the spatial interactions with the IL-13alpha/IL-4Ralpha receptor', Immunology and Cell Biology, 79 332-339 (2001) [C1]
Citations Scopus - 5Web of Science - 4
2001 Webb D, McKenzie A, Matthaei K, Rothenberg M, Foster PS, 'Distinct spatial requirement for eosinophil-induced airways hyperreactivity', Immunology and Cell Biology, 79 165-169 (2001) [C1]
Citations Scopus - 10Web of Science - 9
2001 Kumar R, Foster PS, 'Murine model of chronic human asthma', Immunology and Cell Biology, 79 141-144 (2001) [C1]
Citations Scopus - 36Web of Science - 33
2001 Yang M, Hogan S, Henry P, Matthaei K, McKenzie A, Young I, et al., 'Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin', American Journal of Respiratory Cell and Molecular Biology, 25 522-530 (2001) [C1]
Citations Scopus - 118Web of Science - 106
2001 Hogan SP, Mishra A, Brandt EB, Royalty MP, Pope SM, Zimmermann N, et al., 'A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation', NATURE IMMUNOLOGY, 2 353-360 (2001)
DOI 10.1038/86365
Citations Scopus - 208Web of Science - 170
2001 Hogan SP, Mishra A, Brandt EB, Royalty MP, Pope SM, Zimmerman N, et al., 'A pathological role for cotaxin and eosinophils in experimental oral antigen-induced eosinophilic gastrointestinal inflammation.', Nat Immunol. 2:353-360, 353-360 (2001) [C1]
2000 Webb D, McKenzie A, Koskinen A, Yang M, Mattes J, Foster PS, 'Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity', Journal of Immunology, 165 108-113 (2000) [C1]
Citations Scopus - 223Web of Science - 201
Co-authors Joerg Mattes
2000 Mould A, Ramsay A, Matthaei K, Young I, Rothenberg M, Foster PS, 'The effect of IL-5 and eotaxin expression in the lung on eosinophil trafficking and degranulation and the induction of bronchial hyperreactivity', Journal of Immunology, 164 2142-2150 (2000) [C1]
Citations Scopus - 127Web of Science - 120
2000 Foster PS, Ming Y, Matthei K, Young I, Temelkovski J, Kumar R, 'Dissociation of inflammatory and epithelial responses in a murine model of chronic asthma', Laboratory Investigation, 80 655-662 (2000) [C1]
Citations Scopus - 73Web of Science - 68
2000 Mahalingam S, Foster PS, Lobigs M, Farber J, Karupiah G, 'Interferon-inducible chemokines and immunity to poxvirus infections', Immunological Reviews, 177 127-133 (2000) [C3]
Citations Scopus - 17Web of Science - 18
1999 Mishra A, Hogan S, Lee J, Foster PS, Rothenberg M, 'Fundamental signals that regulate eosinophil homing to the gastrointestinal tract', Journal of Clinical Investigation, 103 1719-1727 (1999) [C1]
Citations Scopus - 228Web of Science - 204
1999 Xiong Y, Karupiah G, Hogan S, Foster PS, Ramsay A, 'Inhibition of allergic airway inflammation in mice lacking nitric oxide synthase 2', Journal of Immunology, 162 445-452 (1999) [C1]
Citations Scopus - 124Web of Science - 110
1999 Rothenberg M, Zimmermann N, Mishra A, Brandt E, Birkenberger L, Hogan S, Foster PS, 'Chemokines and chemokine receptors: their role in allergic airway disease', Journal of Clinical Immunology, 19 250-265 (1999) [C2]
Citations Scopus - 71Web of Science - 67
1999 Foster PS, 'STAT6: an intracellular target for the inhibition of allergic disease', Clinical and Experimental Allergy, 29 12-16 (1999) [C3]
Citations Scopus - 30Web of Science - 27
1999 Foster PS, 'Allergic networks regulating eosinophilia', American Journal of Respiratory Cell and Molecular Biology, 21 451-454 (1999) [C2]
Citations Scopus - 22Web of Science - 18
1999 Foster PS, Hogan S, 'The use of murine models to investigate the immune metworks underlying asthma', Current Opinion in Anti-inflammatory and Immunomod, 1 433-441 (1999) [C1]
1998 Hogan S, Foster PS, Tan X, Ramsay A, 'Mucosal IL-12 gene delivery inhibits allergic airways disease and restores local antiviral immunity', European Journal of Immunology, 28 413-423 (1998) [C1]
Citations Scopus - 111Web of Science - 97
1998 Hogan S, Matthaei K, Young J, Koskinen A, Young I, Foster PS, 'A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5', Journal of Immunology, 161 1501-1509 (1998) [C1]
Citations Scopus - 248Web of Science - 227
1998 Temelkovski J, Hogan S, Shepherd D, Foster PS, Kumar R, 'An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen', Thorax, 53 849-856 (1998) [C1]
Citations Scopus - 259Web of Science - 218
1998 Hogan S, Koskinen A, Matthaei K, Young I, Foster PS, 'Interleukin-5-producing CD4+ T cells play a pivotal role in aeroallergen-induced eosinophilia, bronchial hyperreactivity, and lung damage in mice', American Journal of Respiratory and Critical Care Medicine, 157 210-218 (1998) [C1]
Citations Scopus - 158Web of Science - 147
1997 Hogan S, Mould A, Kikutani H, Ramasy A, Foster PS, 'Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins', Journal of Clinical Investigation, 99 1329-1339 (1997) [C1]
Citations Scopus - 216Web of Science - 205
1997 Mould A, Matthaei K, Young I, Foster PS, 'Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice', Journal of Clinical Investigation, 99 1064-1071 (1997) [C1]
Citations Scopus - 266Web of Science - 252
1997 Kourie J, Foster PS, Dulhunty A, 'Inositol polyphosphates modify the kinetics of a small chloride channel in skeletal muscle sarcoplasmic reticulum', Journal of Membrane Biology: an international journal for studies on the structure function and genesis of biomembranes, 157 147-158 (1997) [C1]
Citations Scopus - 16Web of Science - 16
1997 Hogan S, Foster PS, 'Cytokines as targets for the inhibition of eosinophilic inflammation', Pharmacology and Therapeutics, 74 259-283 (1997) [C2]
Citations Web of Science - 26
1997 Matthaei K, Foster PS, Young I, 'The role of interleukin-5 (IL-5) in vivo: Studies with IL-5 deficient mice', Memorias do Instituto Oswaldo Cruz Rio de Janeiro, 92 63-68 (1997) [C1]
Citations Scopus - 25Web of Science - 24
1997 Foster PS, Hogan S, Matthaei K, Young I, 'Interleukin-4 and interleukin-5 as targets for the inhibition of eosinophilic inflammation and allergic airways hyperreactivity', Memorias do Instituto Oswaldo Cruz Rio de Janeiro, 92 55-61 (1997) [C1]
Citations Scopus - 10Web of Science - 10
1997 Hogan S, Koskinen A, Foster PS, 'Interleukin-5 and eosinophils induce airway damage and bronchial hyperreactivity during allergic airway inflammation in BALB/c mice', Immunology and Cell Biology, 75 284-288 (1997) [C1]
Citations Scopus - 92Web of Science - 82
1996 Foster PS, Hogan S, Ramsay A, Matthaei K, Young I, 'Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model', Journal of Experimental Medicine, 183 195-201 (1996) [C1]
Citations Scopus - 1115Web of Science - 1044
1996 Hogan S, Foster PS, 'Cellular and molecular mechanisms involved in the regulation of eosinophil trafficking in vivo', Medicinal Research Reviews, 16 407-432 (1996) [C1]
Citations Scopus - 20Web of Science - 21
1996 Denborough M, Hopkinson K, O'Brien R, Foster PS, 'Overheating alone can trigger malignant hyperthermia in piglets', Anaesthesia and Intensive Care, 24 348-354 (1996) [C1]
Citations Scopus - 13Web of Science - 10
1995 Taske N, Eyre H, O'Brien R, Sutherland G, Denborough M, Foster PS, 'Molecular cloning of the cDNA encoding human skeletal muscle triadin and its localisation to chromosome 6q22-6q23', The Federation of European Biochemical Societies (FEBS) Journal, 233 258-265 (1995) [C1]
Citations Scopus - 11Web of Science - 11
1995 O'Brien R, Taske N, Hansbro P, Matthaei K, Hogan S, Denborough M, Foster PS, 'Exclusion of defects in the skeletal muscle specific regions of the DHPR alpha 1 subunit as frequent causes of malignant hyperthermia', Journal of Medical Genetics, 32 913-914 (1995) [C1]
Citations Scopus - 6Web of Science - 8
Co-authors Philip Hansbro
1994 Hansbro P, Foster PS, Hogan S, Ozaki S, Denborough M, 'Purification and characterization of D-myo-Inositol (1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase from skeletal muscle', Archives of Biochemistry and Biophysics, 311 47-54 (1994) [C1]
Citations Scopus - 3Web of Science - 5
Co-authors Philip Hansbro
1994 Foster PS, Hansbro P, Liu C, Potter B, Denborough M, 'Kinetic analysis of novel inhibitors of inositol polyphosphate metabolism', Biochemical and Biophysical Research Communications, 200 8-15 (1994) [C1]
Citations Scopus - 3Web of Science - 3
Co-authors Philip Hansbro
1994 Foster PS, Hogan S, Hansbro P, O'Brien R, Potter B, Ozaki S, Denborough M, 'The metabolism of D-myo-inositol 1,4,5-trisphosphate and D-myo-inositol 1,3,4,5-tetrakisphosphate by porcine skeletal muscle', European Journal of Biochemistry, 222 955-964 (1994) [C1]
Citations Scopus - 12Web of Science - 12
Co-authors Philip Hansbro
1994 Foster PS, 'The role of phosphoinositide metabolism in Ca2+ signalling of skeletal muscle cells', The International Journal of Biochemistry and Cell Biology, 26 449-468 (1994) [C1]
Citations Scopus - 11Web of Science - 12
1994 Hogan S, Foster PS, Hansbro P, Ozaki S, Denborough M, 'Detection and partial purification of inositol 1,4,5-trisphosphate 3-kinase from porcine skeletal muscle', Cellular Signalling, 6 233-243 (1994) [C1]
Citations Scopus - 5Web of Science - 4
Co-authors Philip Hansbro
1993 Foster PS, Denbobourgh M, 'The effect of calcium channel antagonists and BAY K 8644 on calcium fluxes of malignant hyperpyrexia-susceptible muscle', The International Journal of Biochemistry and Cell Biology, 25 495-504 (1993) [C1]
Citations Scopus - 1Web of Science - 2
1993 Foster PS, Gesini E, Denborough M, 'Inositol 1,4,5-trisphosphate metabolism in red blood cells from individuals susceptible to malignant hyperpyrexia', Lancet, 342 986-987 (1993) [C3]
Citations Scopus - 9Web of Science - 8
1992 Foster PS, Hopkinson K, Denborough M, 'Propofol anaesthesia in malignant hyperpyrexia susceptible swine', Clinical and Experimental Pharmacology and Physiology, 19 183-186 (1992) [C1]
Citations Scopus - 4Web of Science - 4
1991 Foster PS, Hopkinson K, Payne N, Denborough M, 'The effect of azumolene on hypercontractility and sarcoplasmic reticulum Ca(2+)-dependent ATPase activity of malignant hyperpyrexia-susceptible porcine skeletal muscle', Clinical and Experimental Pharmacology and Physiology, 18 489-495 (1991) [C1]
Citations Scopus - 8Web of Science - 9
1990 FOSTER PS, 'MALIGNANT HYPERPYREXIA', INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 22 1217-1222 (1990)
DOI 10.1016/0020-711X(90)90301-I
Citations Scopus - 9Web of Science - 10
1990 Foster PS, 'Malignant hyperpyrexia (Short Survey)', The International Journal of Biochemistry and Cell Biology, 22 1217-1222 (1990) [C1]
1989 Foster PS, Denborough M, 'Effect of diltiazem and dantrolene on the contractility of isolated malignant hyperpyrexia-susceptible porcine skeletal muscle', British Journal of Anaesthesia, 62 566-572 (1989) [C1]
Citations Scopus - 6Web of Science - 13
1989 Foster PS, Hopkinson K, Denborough M, 'Effect of diltiazem on porcine malignant hyperpyrexia induced by suxamethonium and halothane', British Journal of Anaesthesia, 62 560-565 (1989) [C1]
Citations Scopus - 1Web of Science - 3
1989 Foster PS, White M, Denborough M, 'Characterization of the terminal cisternae and longitudinal tubules of sarcoplasmic reticulum from malignant hyperpyrexia susceptible porcine skeletal muscle', International Journal of Biochemistry, 21 1119-1126 (1989) [C1]
Citations Scopus - 6Web of Science - 7
1989 Foster PS, Claudianos C, Gesini E, Hopkinson K, Denborough M, 'Inositol 1,4,5,-trisphosphate phosphatase deficiency and malignant hyperpyrexia in swine', Lancet, 2 124-127 (1989) [C1]
Citations Scopus - 43Web of Science - 62
1989 Foster PS, Hopkinson K, Denborough MA, '31P-NMR spectroscopy: The metabolic profile of malignant hyperpyrexic porcine skeletal muscle', Muscle and Nerve, 12 390-396 (1989)

31Phosphorus-NMR spectroscopy may have the potential to help in the noninvasive diagnosis of malignant hyperpyrexia (MH). Changes in the phosphate-metabolite profile of MH-suscept... [more]

31Phosphorus-NMR spectroscopy may have the potential to help in the noninvasive diagnosis of malignant hyperpyrexia (MH). Changes in the phosphate-metabolite profile of MH-susceptible (MHS) skeletal muscle occur more readily under conditions of anoxia than in control muscle. Induction of anoxia causes a rapid fall in intracellular phosphocreatine, an elevation of inorganic phosphate, and finally a diminution of ATP in MHS muscle. The onset of metabolic change was slower in control tissue. Increased oxygen consumption may occur in anoxic MHS muscle, which leads to accelerated glycolysis and a rapid fall in the intracellular high-energy phosphates. In MHS muscle an abnormality may exist in carbohydrate metabolism linked with poor resynthesis of the high-energy phosphates, which may be precipitated under anaerobic conditions. Accelerated muscle metabolism is also observed in the presence of 2 mM caffeine and 3% halothane in MHS muscle. Changes in the concentrations of metabolites could be mapped noninvasively under anoxic conditions using topical 31P-NMR.

Citations Scopus - 6
1989 Foster PS, Hopkinson K, Denborough M, '31P-NMR spectroscopy: The metabolic profile of malignant hyperpyrexic porcine skeletal muscle', Muscle and Nerve, 12 390-396 (1989) [C1]
Citations Web of Science - 8
1989 Foster PS, Hopkinson K, Denborough M, 'Effect of diltiazem, verapamil and dantrolene on the contractility of isolated malignant hyperpyrexia-susceptible human skeletal muscle', Clinical and Experimental Pharmacology and Physiology, 16 799-805 (1989) [C1]
Citations Scopus - 2Web of Science - 4
1983 Foster PS, Goldie R, Paterson J, Spina D, 'Effect of hypothermia on beta 1-adrenoceptor-mediated relaxation of pig bronchus', British Journal of Pharmacology, 80 699-702 (1983) [C1]
Citations Web of Science - 2
1983 Foster PS, Goldie R, Paterson J, 'Effect of steroids on beta-adrenoreceptor-mediated relaxation of pig bronchus', British Journal of Pharmacology, 78 441-445 (1983) [C1]
Citations Web of Science - 91
Show 224 more journal articles

Review (3 outputs)

Year Citation Altmetrics Link
2016 Maltby S, Plank M, Tay HL, Collison A, Foster PS, 'Targeting MicroRNA Function in Respiratory Diseases: Mini-Review.', Front Physiol (2016)
DOI 10.3389/fphys.2016.00021
Citations Scopus - 1Web of Science - 1
Co-authors Steven Maltby
2013 Plank M, Maltby S, Mattes J, Foster PS, 'Targeting translational control as a novel way to treat inflammatory disease: The emerging role of MicroRNAs', Clinical and Experimental Allergy (2013) [C1]

Chronic inflammatory diseases (e.g. asthma and chronic obstructive pulmonary disease) are leading causes of morbidity and mortality world-wide and effective treatments are limited... [more]

Chronic inflammatory diseases (e.g. asthma and chronic obstructive pulmonary disease) are leading causes of morbidity and mortality world-wide and effective treatments are limited. These disorders can often be attributed to abnormal immune responses to environmental stimuli and infections. Mechanisms leading to inflammation are complex, resulting from interactions of structural cells and activation of both the adaptive and innate arms of the immune system. The activation of structural and immune cells involves both temporary and permanent changes in gene expression in these cells, which underpin chronic inflammation and tissue dysfunction. miRNAs are small non-coding RNAs increasingly being recognized to play important roles in the post-transcriptional regulation of gene expression in mammalian cells by regulating translation. Individual miRNAs can exert their effects by directly inhibiting the translation or stability of multiple mRNAs simultaneously. Thus, the expression or blockade of function of a single miRNA (miR) can result in pronounced alterations in protein expression within a given cell. Dysregulation of miRNA expression may subsequently alter cellular function, and in certain situations predispose to disease. Our current understanding of the role of miRNA in the regulation of inflammatory disease (e.g. allergic diseases) remains limited. In this review, we provide an overview of the current understanding of miRNA biogenesis and function, the roles miRNA play in the regulation of immune cell function and their potential contribution to inflammatory diseases. We also highlight strategies to alter miRNA function for experimental or therapeutic gain, and discuss the potential utility and limitations of targeting these molecules as anti-inflammatory strategies. © 2013 John Wiley & Sons Ltd.

DOI 10.1111/cea.12135
Citations Scopus - 19Web of Science - 18
Co-authors Steven Maltby, Joerg Mattes
2013 Plank M, Maltby S, Mattes J, Foster PS, 'Targeting translational control as a novel way to treat inflammatory disease: the emerging role of microRNAs.', Clinical and Experimental Allergy (2013) [C1]
DOI 10.1111/cea.12170
Co-authors Joerg Mattes, Steven Maltby

Conference (110 outputs)

Year Citation Altmetrics Link
2016 Hadjigol S, Maltby S, Yang M, Foster P, 'UNDERSTANDING MECHANISMS OF BACTERIAL-INDUCED DISEASE EXACERBATION IN A MOUSE MODEL OF ALLERGIC AIRWAYS DISEASE', RESPIROLOGY (2016)
Co-authors Steven Maltby, Ming Yang
2015 Kim R, Horvat J, Pinkerton J, Starkey M, Essilfie A, Mayall J, et al., 'INFECTION-INDUCED MICRORNA-21 DRIVES SEVERE, STEROID-INSENSITIVE EXPERIMENTAL ASTHMA BY AMPLIFYING PI3K-MEDIATED SUPPRESSION OF HDAC2', RESPIROLOGY (2015) [E3]
Co-authors Malcolm Starkey, Jay Horvat, Simon Keely, Philip Hansbro, Joerg Mattes
2015 Tay H, Kaiko G, Plank M, Li J, Essilfie A, Maltby S, et al., 'THE ROLE OF MIR-328 IN RESPIRATORY DISEASES', RESPIROLOGY (2015) [E3]
Co-authors Joerg Mattes, Ming Yang, Steven Maltby, Philip Hansbro
2014 Starkey M, Hanish I, Dua K, Nair P, Haw T, Hsu A, et al., 'Interleukin-13 predisposes mice to more severe influenza infection by suppressing interferon responses and activating microRNA-21/PI3K', CYTOKINE (2014) [E3]
DOI 10.1016/j.cyto2014.07.182
Co-authors Peter Wark, Philip Hansbro, Darryl Knight, Alan Hsu, Jay Horvat, Malcolm Starkey
2014 Collison A, Hatchwell L, Girkin J, Li J, Parsons K, Bartlett N, et al., 'REDUCED TLR7 EXPRESSION MAY UNDERPIN IMPAIRED RESPONSE TO VIRAL INFECTION IN ASTHMA', RESPIROLOGY (2014) [E3]
DOI 10.1111/resp.12263_5
Co-authors Joerg Mattes, Peter Wark
2013 Tay H, Kaiko G, Hansbro P, Foster P, 'The role of miRNA in regulating bacterial clearance', JOURNAL OF IMMUNOLOGY (2013) [E3]
Co-authors Philip Hansbro
2013 Hansbro P, Beckett E, Stevens R, Jarnicki A, Kim R, Hanish I, et al., 'A short-term model of COPD identifies a role for mast cell tryptase', JOURNAL OF IMMUNOLOGY (2013) [E3]
Co-authors Philip Hansbro, Ming Yang, Peter Wark, Jay Horvat, Nicole Hansbro, Simon Keely
2013 Hansbro P, Horvat J, Essilfie A-T, Kim R, Mayall J, Starkey M, Foster P, 'Macrolides suppress key features of experimental steroid-sensitive and steroid-resistant asthma', JOURNAL OF IMMUNOLOGY (2013) [E3]
Co-authors Malcolm Starkey, Philip Hansbro, Jay Horvat
2013 Girkin J, Hatchwell L, Foster PS, Johnston SL, Collison A, Mattes J, 'SALMETEROL ATTENUATES CHEMOTAXIS IN RHINOVIRUS-INDUCED EXACERBATION OF ASTHMA VIA MODULATION OF PP2A', RESPIROLOGY (2013) [E3]
Co-authors Joerg Mattes
2013 Kim RY, Horvat JC, Starkey MR, Essilfie A-T, Foster PS, Hansbro PM, 'MICRORNA INHIBITION IN NEONATAL CHLAMYDIA LUNG INFECTION PREVENTS INFECTION-INDUCED LUNG PATHOLOGY IN LATER LIFE', RESPIROLOGY (2013) [E3]
Co-authors Malcolm Starkey, Philip Hansbro, Jay Horvat
2013 Herbert C, Siegle JS, Shadie AM, Nikolaysen S, Garthwaite L, Hansbro NG, et al., 'EARLY LIFE EXPOSURE TO ENVIRONMENTAL PARTICULATES PREDISPOSES TO DEVELOPMENT OF ASTHMATIC INFLAMMATION', RESPIROLOGY (2013) [E3]
Co-authors Nicole Hansbro
2013 Hatchwell L, Collison A, Phipps S, Foster PS, Johnston SL, Mattes J, 'CCL7 (MCP-3) MEDIATES RHINOVIRUS-INDUCED LUNG INFLAMMATION AND EXACERBATION OF ALLERGIC AIRWAY DISEASE', RESPIROLOGY (2013) [E3]
Co-authors Joerg Mattes
2013 Horvat JC, Essilfie A-T, Kim RY, Mayall JR, Starkey MR, Beckett EL, et al., 'MACROLIDES SUPPRESS KEY FEATURES OF EXPERIMENTAL STEROID-SENSITIVE AND STEROID-RESISTANT ASTHMA', RESPIROLOGY (2013) [E3]
Co-authors Jodie Simpson, Jay Horvat, Philip Hansbro, Peter Gibson, Malcolm Starkey
2012 Kaiko GE, Tay HL, Plank MW, Hansbro PM, Foster PS, 'MicroRNA regulate bacterial phagocytosis in the lung', Immunology: Abstracts of the European Congress of Immunology (2012) [E3]
Co-authors Philip Hansbro
2012 Starkey M, Kim R, Horvat J, Essilfie A-T, Beagley K, Mattes J, et al., 'Constitutive IL-13 promotes respiratory chlamydial infection and infection-induced chronic airway hyper-responsiveness', JOURNAL OF IMMUNOLOGY (2012) [E3]
Co-authors Joerg Mattes, Philip Hansbro, Jay Horvat
2012 Collison AM, Hatchwell LM, Siqueira AP, Bartlett NW, Johnston SL, Foster PS, Mattes J, 'Antagonism of microRNA-122 is comparible to azithromycin treatment in a mouse model of rhinovirus-induced exacerbation of allergic airways disease', Respirology (2012) [E3]
Co-authors Joerg Mattes
2012 Hatchwell LM, Collison AM, Siqueira AP, Bartlett NW, Johnston SL, Foster PS, Mattes J, 'Toll-like receptor 7 mediates anti-viral responses to rhinovirus while suppressing exacerbation of asthma', Respirology (2012) [E3]
Co-authors Joerg Mattes
2012 Hatchwell LM, Collison AM, Siqueira AP, Bartlett NW, Johnston SL, Foster PS, Mattes J, 'TRAIL regulates inflammatory responses to rhinovirus and rhinovirus-induced exacerbation of asthma', Respirology (2012) [E3]
Co-authors Joerg Mattes
2012 Horvat JC, Essilfie A-T, Kim RY, Mayall JR, Starkey MR, Beckett EL, et al., 'Efficacy of antibiotic-based therapeutic strategies for the treatment of infection-induced, steroid-resistant allergic airways disease', Respirology (2012) [E3]
Co-authors Malcolm Starkey, Philip Hansbro, Jay Horvat
2012 Kaiko GE, Phipps S, Plank MW, Tay HL, Lam CE, Foster PS, 'Inhibition of microRNA reverses CD8 T cell exhaustion and improves immunity against respiratory virus infection', Respirology (2012) [E3]
2012 Li J, Foster PS, Yang M, 'Inducible microRNA-X expression underpins steroid- resistant airway hyperresponsiveness by upregulating IL-27 expression', Respirology (2012) [E3]
Co-authors Ming Yang
2012 Plank MW, Kaiko GE, Luck H, Li J, Mattes J, Hansbro PM, Foster PS, 'The role of micrornas in CD4 T cell function', Respirology (2012) [E3]
Co-authors Joerg Mattes, Philip Hansbro
2012 Starkey MR, Kim RY, Horvat JC, Essilfie A-T, Beagley KW, Mattes J, et al., 'Constitutive IL-13 promotes respiratory chlamydial infection-induced chronic airway hyperresponsiveness', Respirology (2012) [E3]
Co-authors Joerg Mattes, Malcolm Starkey, Jay Horvat, Philip Hansbro
2012 Tay HL, Kaiko GE, Plank MW, Mattes J, Hansbro PM, Foster PS, 'MiRNAs regulate bacterial infection in lungs', Respirology (2012) [E3]
Co-authors Philip Hansbro, Joerg Mattes
2011 Wu DXY, Ahrens R, Osterfeld H, Groschwitz K, Foster P, Rothenberg ME, et al., 'Interleukin-13 (IL-13)/IL-13 receptor alpha 1 (IL-13R alpha 1) signaling regulates intestinal epithelial Cystic fibrosis transmembrane conductance regulator (CFTR) channel-dependent Cl- secretion', FASEB JOURNAL (2011) [E3]
2011 Foster PS, Tay HL, Kaiko GE, Plank MW, Mattes J, Hansbro PM, 'MiRNA and its roles in regulating bacterial infection in lungs', American Journal of Respiratory and Critical Care Medicine (2011) [E3]
Co-authors Philip Hansbro, Joerg Mattes
2011 Hansbro PM, Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, et al., 'Infection-induced neutrophilic allergic airways disease is resistant to steroid treatment', American Journal of Respiratory and Critical Care Medicine (2011) [E3]
Co-authors Jay Horvat, Peter Gibson, Philip Hansbro, Margaret Dunkley, Jodie Simpson
2011 Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, Beagley KW, et al., 'Investigation of infection-induced steroid resistant asthma', Respirology (2011) [E3]
Co-authors Jay Horvat, Peter Gibson, Margaret Dunkley, Philip Hansbro, Jodie Simpson
2011 Collison AM, Hatchwell LM, Pereira De Siqueira AL, Don A, Verrills NM, Foster PS, Mattes J, 'The development of house dust mite-induced allergic airways disease is regulated by a novel E3 ubiquitin ligase-dependent deactivation of a protein phosphatase', Respirology (2011) [E3]
Co-authors Joerg Mattes, Nikki Verrills
2011 Hatchwell LM, Collison AM, Pereira De Siqueira AL, Foster PS, Verrills NM, Don A, et al., 'A novel E3 ubiquitin ligase links rhinovirus infection to exacerbation of asthma', Respirology (2011) [E3]
Co-authors Nikki Verrills, Joerg Mattes, Peter Wark
2011 Mattes J, Hankin RG, Hilton JM, Collison AM, Pereira De Siqueira AL, Gulliver T, et al., 'Frequent persistent wheeze in infancy may be associated with impaired FEV0.5 and FVC values', Respirology (2011) [E3]
Citations Web of Science - 1
Co-authors Joerg Mattes
2010 Hansbro PM, Essilfie A-T, Simpson JL, Dunkley ML, Horvat JC, Gibson PG, Foster PS, 'Haemophilus influenzae induces IL-17-mediated neutrophilic allergic airways disease', American Journal of Respiratory and Critical Care Medicine (2010) [E3]
Citations Scopus - 54Web of Science - 47
Co-authors Peter Gibson, Margaret Dunkley, Philip Hansbro, Jodie Simpson, Jay Horvat
2010 Herbert C, Scott MM, Keogh R, Siegle JS, Yuan K, Tedla N, et al., 'Alternatively activated alveolar macrophages stimulate Th2 cytokine production by primed CD4+ T cells in a model of an acute exacerbation of asthma', American Journal of Respiratory and Critical Care Medicine (2010) [E3]
2010 Ptaschinski CM, Phipps S, Hansbro NG, Rosenberg HF, Mattes J, Foster PS, 'MicroRNAs are involved in the regulation of inflammatory responses characteristic of severe respiratory virus infection', American Journal of Respiratory and Critical Care Medicine (2010) [E3]
Co-authors Nicole Hansbro, Joerg Mattes
2010 Thorburn AN, Foster PS, Gibson PG, Hansbro PM, 'Development of a streptococcus pneumoniae-based immunoregulatory therapy for asthma', American Journal of Respiratory and Critical Care Medicine (2010) [E3]
Co-authors Philip Hansbro, Peter Gibson
2010 Thorburn AN, Foster PS, Gibson PG, Hansbro PM, 'Streptococcus pneumoniae vaccine, prevenar, induces regulatory T cells and prevents allergic airways disease', American Journal of Respiratory and Critical Care Medicine (2010) [E3]
Co-authors Philip Hansbro, Peter Gibson
2010 Mattes J, Collison AM, Plank MW, Phipps S, Foster PS, 'The role of microRNA as new anti-inflammatory targets', APCAACI 2010: The 8th Asia Pacific Congress on Allergy, Asthma and Clinical Immunology Programme & Abstracts Handbook (2010) [E3]
Co-authors Joerg Mattes
2010 Siegle J, Hansbro NG, Dong C, Angkasekwinai P, Foster PS, Kumar R, 'Anti-Th2 cytokines inhibit progression in a murine model of childhood asthma', European Respiratory Society Annual Congress 2010. Abstracts (2010) [E3]
Co-authors Nicole Hansbro
2010 Ptaschinski CM, Adachi R, Rosenberg HF, Stevens RL, Foster PS, 'Beneficial role for the tryptase mouse mast cell protease 6 in the innate immune response in the lung to pneumonia virus of mice', Translational Science: From Basic to Clinincal Immunology and Allergy (2010) [E3]
2010 Foster PS, Mattes J, Collison AM, Plank MW, Phipps S, 'MicoRNAs bridge innate and adative immunity: induction of TH2 mediated allergic airways disease', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Abstracts (2010) [E3]
Co-authors Joerg Mattes
2010 Foo A, Lam CE, Foster PS, Phipps S, 'Regulatory T cells suppress the formation of inducible bronchus-associated lymphoid tissue in weanling mice', Respirology (2010) [E3]
2010 Lam CE, Foo A, Essilfie A-T, Hansbro PM, Matthaei KI, Foster PS, Phipps S, 'Chemerin derived peptide reduces LPS and haemophilus influenza-induced emphysema in mice', Respirology (2010) [E3]
Co-authors Philip Hansbro
2009 Foo A, Lam CE, Foster PS, Phipps S, 'Regulatory T cells suppress the development of inducible bronchus-associated lymphoid tissue (iBALT) in weanling mice', 39th Annual Meeting of the Australasian Society for Immunology: Program (2009) [E3]
2009 Hansbro PM, Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Foster PS, 'Early life chlamydial infection enhances allergic airways disease through age-dependent differences in immunopathology', Journal of Immunology (2009) [E3]
DOI 10.1016/j.jaci.2009.10.018
Co-authors Jay Horvat, Peter Gibson, Philip Hansbro, Malcolm Starkey
2009 Hansbro PM, Thorburn AN, Foster PS, Gibson PG, 'Streptococcus pneumoniae vaccine, Prevenar, utilises Tregs to suppress asthma', Journal of Immunology (2009) [E3]
Co-authors Peter Gibson, Philip Hansbro
2009 Horvat JC, Starkey MR, Beagley KW, Gibson PG, Foster PS, Hansbro PM, 'Chlamydial respiratory infection predisposes to neutrophil dominated allergic airways disease (AAD)', Journal of Immunology (2009) [E3]
Co-authors Jay Horvat, Malcolm Starkey, Philip Hansbro, Peter Gibson
2009 Wu DX, Ahrens RE, Groschwitz KR, Osterfield HN, Foster PS, Finkelman FD, et al., 'Elevated intestinal interleukin-13 promotes intestinal epithelial barrier dysfunction', The Journal of Allergy and Clinical Immunology (2009) [E3]
2009 Collison AM, Mattes J, Phipps S, Plank MW, Foster PS, 'MicroRNAs are crucial in the development of airways hyperreactivity', American Journal of Respiratory and Critical Care Medicine (2009) [E3]
Co-authors Joerg Mattes
2009 Foo A, Lam CE, Wark PA, Foster PS, Phipps S, 'Immune mechanisms that promote the development of inducible bronchus-associated lymphoid tissue (iBALT)', American Journal of Respiratory and Critical Care Medicine (2009) [E3]
Co-authors Peter Wark
2009 Lam CE, Foo A, Matthaei KI, Foster PS, Phipps S, 'Repeated stimulation of toll-like receptor 4 is sufficient to induce emphysematous lesions in mice', American Journal of Respiratory and Critical Care Medicine (2009) [E3]
2009 Mattes J, Collison AM, Plank MW, Phipps S, Foster PS, 'MicroRNAs regulate allergic airway inflammation', American Journal of Respiratory and Critical Care Medicine (2009) [E3]
Co-authors Joerg Mattes
2009 Herbert C, Scruton K, Hsu K, Siegle JS, Hansbro NG, Foster PS, et al., 'Enhanced expression of cytokines by pulmonary T-cells and macrophages in a model of exacerbations of chronic asthma', American Journal of Respiratory and Critical Care Medicine (2009) [E3]
Co-authors Nicole Hansbro
2009 Collison AM, De Siqueira A, Plank MW, Foster PS, Mattes J, 'The identification of TRAIL as a mediator of airways remodelling in a chronic model of murine allergic airways disease', American Journal of Respiratory and Critical Care Medicine (2009) [E3]
Co-authors Joerg Mattes
2009 Thorburn AN, O'Sullivan B, Thomas R, Foster PS, Gibson PG, Hansbro PM, 'Prevenar suppresses allergic airways disease through the expansion of regulatory T cells', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Peter Gibson, Philip Hansbro
2009 Siegle JS, Hansbro NG, Herbert C, Rosenberg HF, Asquith KL, Foster PS, Kumar RK, 'Interaction between early-life viral infection and allergen exposure induces an asthmatic phenotype in mice', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01502_7.x
Co-authors Nicole Hansbro
2009 Essilfie A-T, Simpson JL, Dunkley ML, Foster PS, Gibson PG, Hansbro PM, 'Haemophilus influenzae infection induces features of neutrophilic asthma', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Peter Gibson, Jodie Simpson, Philip Hansbro, Margaret Dunkley
2009 Horvat JC, Starkey MR, Beagley KW, Preston JA, Gibson PG, Foster PS, Hansbro PM, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease (AAD)', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Jay Horvat, Malcolm Starkey, Peter Gibson, Philip Hansbro
2009 Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Respirology (2009) [E3]
DOI 10.1016/j.jaci.2009.10.018
Citations Scopus - 54Web of Science - 52
Co-authors Jay Horvat, Philip Hansbro, Malcolm Starkey, Peter Gibson
2009 Weckmann M, Lau J, Grafton K, Oliver B, Hansbro NG, Foster PS, et al., 'Tumstatin: A non-collagenous domain of collagen IV: Effects on inflammation and angiogenesis', Respirology (2009) [E3]
Co-authors Nicole Hansbro, Philip Hansbro
2008 Burgess JK, Boustany S, Oliver BG, Moir LM, Baraket M, Hansbro PM, et al., 'The absence of tumstatin in asthma may lead to angiogenesis and airway hyperresponsiveness', American Journal of Respiratory and Critical Care Medicine (2008) [E3]
Co-authors Philip Hansbro, Nicole Hansbro
2008 Hansbro PM, Essilfie A-T, Foster PS, Gibson PG, 'Haemophilus influenzae (Hi) infection in asthma may drive the development of neutrophilic asthma (NA)', American Journal of Respiratory and Critical Care Medicine (2008) [E3]
Co-authors Philip Hansbro, Peter Gibson
2008 Hansbro PM, Horvat JC, Beagley KW, Gibson PG, Foster PS, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease', American Journal of Respiratory and Critical Care Medicine (2008) [E3]
Co-authors Philip Hansbro, Peter Gibson, Jay Horvat
2008 Hansbro PM, Thorburn AN, Foster PS, Gibson PG, 'Streptococcus Pneumoniae vaccine prevenar: A potential therapy for the suppression of asthma', American Journal of Respiratory and Critical Care Medicine (2008) [E3]
Co-authors Philip Hansbro, Peter Gibson
2008 Yang M, Ma C, Foster PS, 'Antigen-specific TH1 cells induce airway hyper-reactivity in co-operation with lipopolysaccharide in BALB/C mice', Respirology (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Ming Yang
2008 Thorburn AN, Foster PS, Gibson PG, Hansbro PM, 'Streptococcus pneumoniae vaccine prevenar: A potential therapy for the suppression of asthma', Respirology (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Philip Hansbro, Peter Gibson
2008 Horvat JC, Beagley KW, Gibson PG, Foster PS, Hansbro PM, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease', Respirology (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Philip Hansbro, Peter Gibson, Jay Horvat
2008 Essilfie A-T, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Haemophilus influenzae (Hi) infection in asthma may drive the development of neutrophilic asthma (NA)', Respirology (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Margaret Dunkley, Philip Hansbro, Peter Gibson, Jodie Simpson, Jay Horvat
2008 Hansbro NG, Boustany S, Oliver B, Burgess J, Black J, Rosenberg H, et al., 'Early life pneumoviral infection induces the development of pulmonary angiogenesis', Respirology (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Philip Hansbro, Nicole Hansbro
2008 Boustany S, Oliver BG, Moir LM, Black JL, Hansbro PM, Hansbro NG, et al., 'Tumstatin, an angiogenic inhibitor, modulates airway angiogenesis', Respirology (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252_4.x
Co-authors Philip Hansbro, Nicole Hansbro
2008 Hansbro PM, Essilfie A-T, Simpson JL, Dunkley ML, Gibson PG, Foster PS, 'Haemophilus influenzae (HI) infection induces features of neutrophilic asthma', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book (2008) [E3]
Co-authors Peter Gibson, Jodie Simpson, Philip Hansbro, Margaret Dunkley
2008 Hazelwood L, Wood LG, Hansbro PM, Foster PS, 'High fat diet reduces eosinophilic lung inflammation via nicotinic acetylcholine-dependent signaling', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book (2008) [E3]
Co-authors Philip Hansbro, Lisa Wood
2008 Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book (2008) [E3]
Co-authors Malcolm Starkey, Philip Hansbro, Peter Gibson, Jay Horvat
2008 Thorburn AN, O'Sullivan BJ, Thomas R, Foster PS, Gibson PG, Hansbro PM, 'Suppression of allergic airways disease by the Streptococcus pneumoniae vaccine prevenar through the induction of regulatory T cells', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book (2008) [E3]
Co-authors Philip Hansbro, Peter Gibson
2008 Asquith KL, Ramshaw H, Lopez A, Foster PS, 'The IL-3/IL-5/GM-CSF Common beta Receptor Plays a Pivotal Role in Regulating Th2 Immunity and Allergic Airway Inflammation', FASEB JOURNAL (2008) [E3]
Co-authors Philip Hansbro
2007 Phipps S, Lam CE, Kaiko GE, Collison A, Smith L, Mansell A, et al., 'Contribution of multiple toll-like receptors to the development of murine allergic airways inflammation', Immunology and Cell Biology (2007) [E3]
2007 Kaiko GE, Phipps S, Foster PS, 'Importance of CD4 T cells in the clearance of a primary Respiratory Syncytial Virus infection and in protection against the development of exhausted CD8 T cell memory', Immunology and Cell Biology (2007) [E3]
2007 Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Development of allergic airways disease (AAD) is differentially affected by the timing of chlamydial infection relative to allergic sensitization', American Journal of Respiratory and Critical Care Medicine (2007) [E3]
Co-authors Jay Horvat, Philip Hansbro, Peter Gibson
2007 Horvat JC, Garside CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'Development of allergic airways disease is differentially affected by chlamydial respiratory infection at different ages', American Journal of Respiratory and Critical Care Medicine (2007) [E3]
Co-authors Peter Gibson, Philip Hansbro, Nicole Hansbro, Jay Horvat
2007 Kaiko GE, Phipps S, Foster PS, 'Respiratory Syncytial Virus up-regulates PD-1 expression; comparison to a model of CD8 T cell exhaustion in BALB/c mice', Immuno 2007: 13th International Congress of Immunology, Abstracts and Posters (2007) [E3]
2007 Hansbro NG, Boustany S, Oliver BG, Burgess JK, Black JL, Hansbro PM, Foster PS, 'Viral-induced angiogenesis', Immuno 2007: 13th International Congress of Immunology. Abstracts and Posters (2007) [E3]
Co-authors Philip Hansbro, Nicole Hansbro
2007 Essiflie A, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Elucidating the association between Haemophilus influenzae infection and neutrophilic allergic airways disease using mouse models', Immuno 2007: 13th International Congress of Immunology. Abstracts and Posters (2007) [E3]
Co-authors Jodie Simpson, Philip Hansbro, Margaret Dunkley, Jay Horvat, Peter Gibson
2007 Ferguson AL, Beagley KW, Hansbro PM, Foster PS, 'CD4+ T-cell programming by adult and neonatal bacterial infections inhibit the development of allergic airway inflammation in later life', Immuno 2007: 13th International Congress on Immunology. Abstracts and Posters (2007) [E3]
Co-authors Philip Hansbro
2007 Horvat JC, Moller CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'Allergic airways disease (AAD) is differentially affected by chlamydial lung infection at different stages of life', Respirology (TSANZ Abstracts-Posters) (2007) [E3]
DOI 10.1111/j.1440-1843.2007.001050.x
Co-authors Peter Gibson, Nicole Hansbro, Jay Horvat, Philip Hansbro
2007 Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Timing of chlamydial infection relative to allergen exposure differentially affects allergic airways disease', Respirology (TSANZ Abstracts-Posters) (2007) [E3]
Co-authors Jay Horvat, Philip Hansbro, Peter Gibson
2007 Simosn L, Ellyard JI, Dent LA, Matthaei KI, Rothenberg ME, Foster PS, et al., 'Potential role for eosinophils in tumor immune surveillance', Proceedings of the 13th International Congress on Immunology (2007) [E1]
2007 Forbes EE, Groschwitz KR, Ahrens R, Brandt EB, Rothenberg ME, Foster PS, et al., 'Role of Th2-molecules in OVA-induced intestinal anaphylaxis', Journal of Allergy and Clinical Immunology (Program and Abstracts of Papers to be Presented During Scientific Sessions - 2007 AAAAI Annual Meeting) (2007) [E3]
DOI 10.1016/j.jaci.2006.11.660
2006 Forbes EE, Matthaei KI, Newhouse MJ, Foster PS, Hogan SP, 'Gastrointestinal allergic inflammation: IL-9, mast cells and intestinal anaphylaxis', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2006)
DOI 10.1016/j.jaci.2005.12.345
2006 Dixon CM, Christie J, Matthaei KI, Foster PS, Webb DC, 'Identification & characterisation of proteins associated with allergic airways disease (AAD)', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2006)
DOI 10.1016/j.jaci.2005.12.608
2006 Kaiko GE, Phipps S, Lam CE, Hickey DK, Hansbro NG, Foster PS, Beagley KW, 'The chlamydia infection of dendritic cells drives the development of a pro-asthmatic response', Immunology and Cell Biology (2006) [E3]
Co-authors Nicole Hansbro
2006 Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Exacerbation of Allergic Airways Disease (AAD) by Chlamydia is Differentially Affected by the Timing of Infection Relative to Allergen Exposure', Immunology and Cell Biology (2006) [E3]
Co-authors Philip Hansbro, Peter Gibson, Jay Horvat
2006 Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Streptococcus pneumoniae (SPN) lung infection suppresses hallmark features of a mouse model of asthma', Immunology and Cell Biology (2006) [E3]
Co-authors Philip Hansbro, Peter Gibson, Jay Horvat
2006 Horvat JC, Moller CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'The development of allergic airways disease (AAD) is differently affected by chlamydial lung infection at different stages of life', Immunology and Cell Biology (2006) [E3]
Co-authors Philip Hansbro, Nicole Hansbro, Peter Gibson, Jay Horvat
2006 Mattes J, Simpson JL, Foster PS, Gibson PG, 'Trail is upregulated in the airways of asthmatics', Respirology (2006) [E3]
Co-authors Peter Gibson, Joerg Mattes, Jodie Simpson
2006 Horvat JC, Wade MA, Preston JA, Hansbro NG, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease (AAD)', Respirology (2006) [E3]
Co-authors Philip Hansbro, Jay Horvat, Peter Gibson, Nicole Hansbro
2006 Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Inhibition of allergic lung disease by respiratory streptococcus pneumoniae infection', Respirology (2006) [E3]
Co-authors Jay Horvat, Peter Gibson, Philip Hansbro
2006 Horvat JC, Wade MA, Preston JA, Hansbro NG, Gibson PG, Beagley KW, et al., 'Neonatal chlamydial infection exacerbates allergic airways disease', Abstracts ATS 2006 International Conference (2006) [E3]
Co-authors Jay Horvat, Peter Gibson, Nicole Hansbro, Philip Hansbro
2006 Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory Streptococcus pneumoniae infection decreases key inflammatory responses in a mouse model of asthma', Abstracts ATS 2006 International Conference (2006) [E3]
Co-authors Peter Gibson, Philip Hansbro, Jay Horvat
2006 Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Inhibition of allergic lung disease by respiratory Streptococcus pneumoniae infection', 5th International Symposium on Pneumococci and Pneumococcal Diseases (2006) [E3]
Co-authors Philip Hansbro, Peter Gibson, Jay Horvat
2006 Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'The influence of allergic airways disease on the immune response to respiratory Streptococcus pneumoniae infection', 5th International Symposium on Pneumococci and Pneumococcal Diseases (2006) [E3]
Co-authors Jay Horvat, Peter Gibson, Philip Hansbro
2005 Phipps S, Lam E, Newhouse M, Mahalingam S, Foster PS, Matthaei KI, 'Eosinophils Contribute to Antiviral Immunity Through the Expression of TLR7', 'Genetics and The Immune Response' Abstracts of the 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA & Immunogenetics Workshop (2005) [E3]
DOI 10.1111/j.1399-0039.2005.00523.x
2005 Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory streptococcus pneumoniae infection decreases key inflammatory responses in a mouse model of asthma', TISSUE ANTIGENS (2005)
Co-authors Peter Gibson, Jay Horvat, Philip Hansbro
2005 Horvat JC, Wade MA, Preston JA, Newcombe N, Ferguson AL, Kaiko G, et al., 'Neonatal But Not Adult Chlamydial Infection Induces the Development of Allergic Airways Disease Through Novel Mechanisms Involving Inflammation of Mixed Phenotype', Tissue Antigens (2005) [E3]
Citations Web of Science - 1
Co-authors Jay Horvat, Peter Gibson, Philip Hansbro
2005 Horvat JC, Preston JA, Hansbro NG, Ferguson AL, Gibson PG, Beagley KW, et al., 'Neonatal chlamydial infection inhibits the development of allergic airway inflammation in adult mice', Inflammation Research (2005) [E3]
Co-authors Jay Horvat, Nicole Hansbro, Peter Gibson, Philip Hansbro
2005 Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Timing of Streptococcus Pneumoniae (pnc) infection determines the magnitute of the effect on allergic airways inflammation (AAI) in a mouse model of asthma', Respirology (2005) [E3]
Co-authors Philip Hansbro, Peter Gibson, Jay Horvat
2005 Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory Streptococcus Pneumoniae Infection Decreases Eosinophilia and Mucus Cell Hyperplasia in a Mouse Model of Asthma', Respirology (2005) [E3]
Co-authors Jay Horvat, Peter Gibson, Philip Hansbro
2001 Mahalingam S, Karupiah G, Takeda K, Akira S, Matthaei K, Foster PS, 'Enhanced resistance in STAT6-deficient mice to infection with ectromelia virus', Proceedings of the National Academy of Sciences of the United States of America (2001) [E1]
Citations Scopus - 18Web of Science - 14
2000 Hogan S, Mishra A, Brandt E, Foster PS, Rothenberg M, 'A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy', Proceedings of the National Academy of Sciences of the United States of America (2000) [E1]
Citations Scopus - 117Web of Science - 102
2000 Simson L, Foster PS, 'Chemokine and cytokine cooperativity: Eosinophil migration in the asthmatic response', Immunology and Cell Biology (2000) [E1]
Citations Scopus - 28Web of Science - 25
1998 Hogan S, Foster PS, Charlton B, Slattery R, 'Prevention of Th2-mediated murine allergic airways disease by soluble antigen administration in the neonate', Proceedings of the National Academy of Sciences of the United States of America (1998) [E1]
Citations Scopus - 13Web of Science - 12
1998 Hogan S, Mould A, Young J, Rothenberg M, Ramsay A, Matthaei K, et al., 'Cellular and molecular regulation of eosinophil trafficking to the lung', Immunology and Cell Biology (1998) [E1]
Citations Scopus - 26Web of Science - 25
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Grants and Funding

Summary

Number of grants 92
Total funding $20,592,112

Click on a grant title below to expand the full details for that specific grant.


20162 grants / $72,500

Understanding the role of the newly discovered CD4 T helper (Th)-22 cell subset in models of respiratory infection and inflammation$50,000

Funding body: Australian Respiratory Council

Funding body Australian Respiratory Council
Project Team Laureate Professor Paul Foster, Mr Max Plank
Scheme Harry Windsor Medical Research Grants
Role Lead
Funding Start 2016
Funding Finish 2016
GNo G1600038
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Exploring Novel Therapies for Cystic Fibrosis$22,500

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Hock Tay, Laureate Professor Paul Foster, Mr Max Plank, Doctor Steven Maltby
Scheme Project Grant
Role Investigator
Funding Start 2016
Funding Finish 2016
GNo G1600577
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20151 grants / $54,698

Nose only inhalation smoke exposure system for mice$54,698

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Doctor Jay Horvat, Doctor Janet Bristow, Doctor Malcolm Starkey, Doctor Rebecca Vanders
Scheme Equipment Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1501551
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

201411 grants / $3,086,107

Characterising the immune function of a newly discovered CD4 T helper cell (Th22) and understanding its role in allergic inflammation$690,558

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster
Scheme Project Grant
Role Lead
Funding Start 2014
Funding Finish 2016
GNo G1300109
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

New way of treating respiratory infections and airway inflammatory diseases by targeting miRNA $677,562

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Doctor Ming Yang
Scheme Project Grant
Role Lead
Funding Start 2014
Funding Finish 2016
GNo G1300121
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Toll-like receptor 7 and asthma $673,712

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Joerg Mattes, Laureate Professor Paul Foster, Conjoint Professor Peter Wark
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2016
GNo G1300093
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

How resident host defence cells contribute to the development of childhood asthma and severe attacks of asthma $587,562

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Professor Rakesh Kumar
Scheme Project Grant
Role Lead
Funding Start 2014
Funding Finish 2016
GNo G1300100
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Expanding the Genomic Frontier - from Species to Strains and Individuals to Populations$150,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Marc Wilkins, Professor Rick Cavicchioli, Professor Brett Neilan, Professor Rodney Scott, Laureate Professor Paul Foster, Associate Professor Phillip Dickson, Professor Ian Charles, Associate Professor Elizabeth Harry, Associate Professor Steven Djordjevic, Associate Professor Cynthia Whitchurch, Professor Ian Paulsen, Professor Nicolle Packer, Professor Michael Gillings
Scheme Equipment Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1300426
Type Of Funding Internal
Category INTE
UON Y

Expanding the Genomic Frontier - from Species to Strains and Individuals to Populations$128,147

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Marc Wilkins, Professor Rick Cavicchioli, Professor Brett Neilan, Professor Rodney Scott, Laureate Professor Paul Foster, Associate Professor Phillip Dickson, Professor Ian Paulsen, Professor Nicolle Packer, Professor Michael Gillings, Professor Ian Charles, Associate Professor Elizabeth Harry, Associate Professor Steven Djordjevic, Associate Professor Cynthia Whitchurch
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301339
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

The Nanostring nCounter System$75,000

Funding body: Ramaciotti Foundations

Funding body Ramaciotti Foundations
Project Team Professor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
Scheme Major Equipment Award
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1300853
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

The Nanostring nCounter System$40,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
Scheme Equipment Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301083
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Miltenyi Biotec GentleMACS Octo Dissociator with Heaters $23,566

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Darryl Knight, Professor Dirk Van Helden, Professor Joerg Mattes, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Associate Professor Liz Milward, Dr NATHAN Bartlett, Doctor Simon Keely, Doctor Steven Maltby, Doctor Andrew Jarnicki, Doctor Malcolm Starkey, Doctor Adam Collison, Doctor Shaan Gellatly
Scheme Equipment Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1500861
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

The Nanostring nCounter System$20,000

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Professor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
Scheme Research Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301084
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Virus Infections Change the Bone Marrow: Effects on Immunity, Bone Development and Inflammatory Disease$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Steven Maltby, Mr Max Plank, Doctor Hock Tay, Laureate Professor Paul Foster
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1401394
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20134 grants / $1,680,124

HMRI MRSP Infrastructure (12-16) - VIVA Program$1,633,124

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Laureate Professor Paul Foster, Conjoint Professor Peter Gibson
Scheme NSW MRSP Infrastructure Grant
Role Lead
Funding Start 2013
Funding Finish 2016
GNo G1300567
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Molecular and cellular characterisation of TLR7 signalling in rhinovirus-induced asthma exacerbation$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Joerg Mattes, Laureate Professor Paul Foster
Scheme Near Miss
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300692
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
Scheme Equipment Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1201186
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

American Academy of Allergy Asthma & Immunology Annual Meeting, Henry B Gonzalez Convention Centre, San Antonio USA, 22 - 26 February 2013$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Laureate Professor Paul Foster
Scheme Travel Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300349
Type Of Funding Internal
Category INTE
UON Y

201211 grants / $2,174,035

Targeting miRNA to inhibit leukocyte differentiation: a novel anti-inflammatory approach for the treatment of asthma$590,886

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Professor Ian Young
Scheme Project Grant
Role Lead
Funding Start 2012
Funding Finish 2014
GNo G1100129
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Understanding the mechanisms of steroid resistant inflammatory pathways in mouse models of asthma: potential new treatment approaches$514,551

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Doctor Ming Yang
Scheme Project Grant
Role Lead
Funding Start 2012
Funding Finish 2014
GNo G1100099
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

HMRI MRSP Infrastructure (11-12)- VIVA$486,671

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Laureate Professor Paul Foster, Conjoint Professor Peter Gibson
Scheme NSW MRSP Infrastructure Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1101137
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

BD FACSAria III Cell Sorter: 3 laser 10-colour Flow Cytometer$180,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Laureate Professor Paul Foster, Conjoint Professor Peter Gibson, Laureate Professor John Aitken, Laureate Professor Roger Smith, Professor Rodney Scott
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1100746
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

BD FACSAria III Cell Sorter: 3 laser 10-colour Flow Cytometer$150,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Laureate Professor Paul Foster, Professor Trevor Day, Conjoint Professor Peter Gibson, Laureate Professor John Aitken, Laureate Professor Roger Smith, Professor Rodney Scott
Scheme Equipment Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1100744
Type Of Funding Internal
Category INTE
UON Y

BD FACSAria III Cell Sorter: 3 laser 10-colour Flow Cytometer$122,927

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Laureate Professor Paul Foster, Conjoint Professor Peter Gibson, Laureate Professor John Aitken, Laureate Professor Roger Smith, Professor Rodney Scott
Scheme Project Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200668
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

SpectraMax M5e Multi-Mode Microplate Reader$50,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Linda Howland, Doctor Kelly Asquith
Scheme Equipment Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1100975
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Australia-Harvard Fellowship$36,000

Funding body: Harvard Club of Australia Foundation

Funding body Harvard Club of Australia Foundation
Project Team Laureate Professor Paul Foster
Scheme Australia-Harvard Fellowships
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200214
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Australia-Harvard Fellowship - Allen$26,000

Funding body: Harvard Club of Australia Foundation

Funding body Harvard Club of Australia Foundation
Project Team Laureate Professor Paul Foster
Scheme Australia-Harvard Fellowships
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200238
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Elucidating the mechanisms of steroid-resistant asthma$15,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jay Horvat, Professor Phil Hansbro, Laureate Professor Paul Foster
Scheme Research Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200190
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

American Academy of Allergy Asthma and Immunology Annual Meeting 2012, Orlando, Florida, 2 - 6 March 2012$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Laureate Professor Paul Foster
Scheme Travel Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200407
Type Of Funding Internal
Category INTE
UON Y

201112 grants / $3,438,902

Targeting microRNA (miRNA) as a unified therapeutic approach to the treatment of asthma and allergic inflammation$651,732

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Professor Joerg Mattes, Professor Rakesh Kumar
Scheme Project Grant
Role Lead
Funding Start 2011
Funding Finish 2013
GNo G1000262
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Mast cell proteases suppress respiratory viral infections and allergic inflammation of the airways$642,561

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Dr Michele Grimbaldeston
Scheme Project Grant
Role Lead
Funding Start 2011
Funding Finish 2013
GNo G1000260
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Establishment of a comprehensive regional biophysical analysis facility $500,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Peter Lewis, Professor Nicholas Dixon, Professor Eileen McLaughlin, Professor Adam McCluskey, Associate Professor Aaron Oakley, Laureate Professor Paul Foster, Laureate Professor John Aitken, Associate Professor Jennifer Beck, Dr Michael Kelso, Professor Graham Nicholson, Associate Professor Elizabeth Harry, Professor Ian Charles, Associate Professor Steven Djordjevic
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1000630
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

HMRI MRSP Infrastructure Grant (10-11) VIVA$485,452

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Peter Gibson, Laureate Professor Paul Foster
Scheme NSW MRSP Infrastructure Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100162
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Establishment of a Biomolecular Analysis Facility$325,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Peter Lewis, Professor Eileen McLaughlin, Professor Adam McCluskey, Laureate Professor Paul Foster, Laureate Professor John Aitken
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1000465
Type Of Funding Internal
Category INTE
UON Y

Development of microbial bioproducts for the suppression of inflammation$285,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rakesh Kumar
Scheme Discovery Projects
Role Investigator
Funding Start 2011
Funding Finish 2013
GNo G1000021
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Establishment of a comprehensive regional biophysical analysis facility $230,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Peter Lewis, Professor Nicholas Dixon, Professor Eileen McLaughlin, Professor Adam McCluskey, Associate Professor Aaron Oakley, Laureate Professor Paul Foster, Laureate Professor John Aitken, Associate Professor Jennifer Beck, Dr Michael Kelso, Professor Graham Nicholson, Associate Professor Elizabeth Harry, Professor Ian Charles, Associate Professor Steven Djordjevic
Scheme Linkage Infrastructure Equipment & Facilities (LIEF) Partner Funding
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100484
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

DVCR Special Grant 2011$140,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Laureate Professor Paul Foster
Scheme Special Project Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1101011
Type Of Funding Internal
Category INTE
UON Y

Research microscope, confocal ready nikon eclipse 90i microscope$69,157

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Roger Smith, Conjoint Professor Tamas Zakar, Professor Jon Hirst, Doctor Kaushik Maiti, Doctor Gemma Madsen, Professor Rodney Scott, Conjoint Professor Peter Wark, Laureate Professor Paul Foster, Professor Phil Hansbro, Conjoint Professor Ian Wright
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100024
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Maitland Cancer Appeal Committee Donation - Lung Cancer Mouse Model$50,000

Funding body: Maitland Cancer Appeal Committee

Funding body Maitland Cancer Appeal Committee
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Doctor Gough Au
Scheme Research Project
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100246
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Joerg Mattes, Doctor Simon Keely, Doctor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Laureate Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100037
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Sparke Helmore/NBN Triathlon Award for Research Excellence$15,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Laureate Professor Paul Foster
Scheme Sparke Helmore/NBN Television Corporate Triathlon Award for Research Excellence
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1000985
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20109 grants / $1,897,788

The role of microRNAs in the regulation of antiviral and inflammatory responses during experimental rhinovirus infection$583,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Joerg Mattes, Laureate Professor Paul Foster
Scheme Project Grant
Role Investigator
Funding Start 2010
Funding Finish 2012
GNo G0190183
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

HMRI MRSP Infrastructure Grant (09-10) - VIVA$397,696

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Laureate Professor Paul Foster, Conjoint Professor Peter Gibson
Scheme NSW MRSP Infrastructure Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G1000232
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Laser microdissection microscopy system for cell and development biology$350,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Eileen McLaughlin, Conjoint Professor Keith Jones, Laureate Professor John Aitken, Professor Brett Nixon, Doctor Shaun Roman, Professor Alan Brichta, Doctor Rick Thorne, Doctor Doug Smith, Associate Professor David McCurdy, Emeritus Professor Ray Rose, Professor Christopher Grof, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Associate Professor Brett Graham, Associate Professor Paul Tooney, Laureate Professor Roger Smith, Laureate Professor Paul Foster, Professor Trevor Day, Professor Robert Callister
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0190369
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Mechanisms of induction and progression of childhood asthma: investigations in a mouse model $240,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Rakesh Kumar, Laureate Professor Paul Foster, Dr Megan Hitchins
Scheme Project Grant
Role Lead
Funding Start 2010
Funding Finish 2012
GNo G0900216
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Buxco FinePointe software and FinePointe RC system for mice $39,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Nicole Hansbro, Doctor Simon Phipps, Doctor Ming Yang, Doctor Kelly Asquith, Doctor Catherine Ptaschinski, Professor Rakesh Kumar, Professor Judith Black
Scheme Equipment Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G1000053
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Molecular markers of reversible airway obstruction in early life and correlation with clinical wheezing patterns$19,842

Funding body: Hunter Children`s Research Foundation

Funding body Hunter Children`s Research Foundation
Project Team Professor Joerg Mattes, Laureate Professor Paul Foster, Conjoint Associate Professor Bruce Whitehead, Doctor Ana Pereira De Siqueira
Scheme Research Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0900119
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

The 8th Asia Pacific Congress of Allergy, Asthma and Clinical Immunology, Singapore, 6 - 9 November 2010$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Laureate Professor Paul Foster
Scheme Travel Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G1000937
Type Of Funding Internal
Category INTE
UON Y

20095 grants / $630,650

Coulter counter$41,150

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Simon Phipps, Doctor Ming Yang, Doctor Nicole Hansbro, Doctor Kelly Asquith
Scheme Equipment Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0189851
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Development of novel therapeutic approaches for rhinovirus - induced asthma exacerbation$24,500

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Joerg Mattes, Laureate Professor Paul Foster, Conjoint Professor Peter Wark
Scheme Project Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189800
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Immunisation against chlamydia-associated asthma$20,000

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding body Rebecca L Cooper Medical Research Foundation Ltd
Project Team Doctor Jay Horvat, Professor Phil Hansbro, Laureate Professor Paul Foster
Scheme Research Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189629
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20087 grants / $2,045,882

The role of microRNAs as new anti-inflammatory targets for the treatment of asthma$600,375

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Professor Rakesh Kumar, Assoc. Prof Klaus Matthaei, Professor Joerg Mattes
Scheme Project Grant
Role Lead
Funding Start 2008
Funding Finish 2010
GNo G0187584
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Targeting the shared beta-chain of the IL-3, IL-5 and GM-CSF receptors as therapy for allergic inflammation$585,375

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Professor Angel Lopez
Scheme Project Grant
Role Lead
Funding Start 2008
Funding Finish 2010
GNo G0187585
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The mechanisms underlying pneumoviral-induced angiogenesis of the lung and its impact on the asthmatic response$541,875

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Professor Judith Black
Scheme Project Grant
Role Lead
Funding Start 2008
Funding Finish 2010
GNo G0187591
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Role of IL-3 in allergic inflammation: modulation of basophils, mast cells, eosinophils and remodelling in asthma$235,050

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster
Scheme Project Grant
Role Lead
Funding Start 2008
Funding Finish 2010
GNo G0189190
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Individually ventilated cages (IVC) and associated ventilator, holding boxes and water bottles$35,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Simon Phipps, Doctor Ming Yang, Doctor Nicole Hansbro, Doctor Kelly Asquith
Scheme Equipment Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188541
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

MicroRNA and antagomirs in the regulation and suppression of interferon (IFN)-g and lipopolysaccharide (LPS) induced steroid-resistant airways hyperreactivity$24,250

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Ming Yang, Laureate Professor Paul Foster
Scheme Project Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188474
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Therapeutic potential of targeting the IL-3/IL-5/GM-CSF common beta receptor to treat allergic inflammation and asthma$23,957

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Kelly Asquith, Laureate Professor Paul Foster
Scheme Project Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188460
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20079 grants / $1,114,488

HMRI - Viruses, Infection/Immunity, Vaccines and Asthma Research Program$692,213

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Laureate Professor Paul Foster, Conjoint Professor Peter Gibson, Conjoint Professor Stephen Graves, Associate Professor Darren Shafren
Scheme NSW MRSP Infrastructure Grant
Role Lead
Funding Start 2007
Funding Finish 2009
GNo G0187930
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Influence of early-life viral infection on severity of murine chronic asthma and acute exacerbations$231,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Professor Rakesh Kumar
Scheme Project Grant
Role Lead
Funding Start 2007
Funding Finish 2009
GNo G0187409
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Differential regulation of human mast cell degranulation by discrete forms of protein phosphatase 2A$50,000

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Professor Alistair Sim, Doctor Nikki Verrills, Laureate Professor Paul Foster, Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Dr Gregory Kranias
Scheme Research Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187247
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Nitric Oxide Monitoring System (NIOX)$45,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Conjoint Associate Professor Vicki Clifton, Conjoint Professor Warwick Giles, Emeritus Professor Michael Hensley, Doctor Vanessa Murphy, Conjoint Professor Peter Wark, Professor Vanessa McDonald, Associate Professor Jodie Simpson, Conjoint Associate Professor Bruce Whitehead, Laureate Professor Paul Foster, Professor Phil Hansbro, Associate Professor Lisa Wood
Scheme Equipment Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188193
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Elucidation of the association between Haemophilus influenzae infection and neutrophilic asthma.$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Phil Hansbro, Associate Professor Jodie Simpson, Laureate Professor Paul Foster, Conjoint Professor Margaret Dunkley
Scheme Project Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187206
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

The role of tumstatin in angiogenesis and asthma$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Laureate Professor Paul Foster, Doctor Nicole Hansbro, Doctor Simon Phipps, Professor Phil Hansbro
Scheme Project Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0187238
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Hewlett Packard 7890 series gas chromatograph with accessories$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Lisa Wood, Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Doctor Vanessa Murphy, Laureate Professor Paul Foster, Professor Phil Hansbro, Conjoint Associate Professor Vicki Clifton, Professor Clare Collins, Conjoint Professor Wayne Smith, Professor John Attia
Scheme Equipment Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188191
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Class II biohazard containment hood and carbon dioxide cell culture incubator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Doctor Vanessa Murphy, Associate Professor Lisa Wood, Laureate Professor Paul Foster, Professor Phil Hansbro
Scheme Equipment Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188192
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

The prevention and treatment of Asthma with a diet high in seafood content$15,525

Funding body: Seafood Services Australia

Funding body Seafood Services Australia
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster
Scheme Seafood Industry Development Fund
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0185404
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

20068 grants / $918,744

PRC Priority Research Centre for Asthma & Respiratory Diseases$524,282

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Laureate Professor Paul Foster, Conjoint Professor Peter Gibson, Conjoint Professor Kenneth Beagley, Emeritus Professor Michael Hensley, Professor Phil Hansbro, Professor Joerg Mattes, Professor Alistair Sim, Conjoint Professor Peter Wark
Scheme Priority Research Centre
Role Lead
Funding Start 2006
Funding Finish 2013
GNo G0186914
Type Of Funding Internal
Category INTE
UON Y

Surveillance and Analysis of Avian Influenza Viruses in Migratory Birds in Australia$249,625

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Dr Ian Barr, Conjoint Professor Peter Wark, Dr Paul Selleck, Dr Simone Warner, Laureate Professor Paul Foster, Dr Aeron Hurt, Dr Irene Peroulis, Dr John Curran, Conjoint Professor Peter Gibson
Scheme Potential Avian Influenza-Induced Pandemic
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186000
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Targeting protein phosphatases to control mast cell activation$50,000

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Professor Alistair Sim, Laureate Professor Paul Foster
Scheme Research Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186027
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

CD4+T-cell programming in early life and neonatal infection.$25,000

Funding body: GlaxoSmithKline Australia

Funding body GlaxoSmithKline Australia
Project Team Laureate Professor Paul Foster, Ms Angela Ferguson
Scheme Support Grant
Role Lead
Funding Start 2006
Funding Finish 2007
GNo G0186837
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Identification of early-life signals induced in response to infection that predispose to asthma in later life$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Kenneth Beagley, Professor Alistair Sim
Scheme Pilot Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186699
Type Of Funding Internal
Category INTE
UON Y

CD4 T Cell Programming by early life and neonatal infection$18,837

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Ms Angela Ferguson, Laureate Professor Paul Foster
Scheme PhD Scholarships
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186002
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Role of TRAIL on development of atopic dermatitis and T helper type 2 immunity$16,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Joerg Mattes, Laureate Professor Paul Foster
Scheme Project Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186098
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

CRC for asthma - shared with Monash University$15,000

Funding body: CRC for Asthma

Funding body CRC for Asthma
Project Team Laureate Professor Paul Foster
Scheme Research Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0186654
Type Of Funding CRC - Cooperative Research Centre
Category 4CRC
UON Y

20057 grants / $2,604,586

Drug targets from new animal models$2,030,948

Funding body: CRC for Asthma

Funding body CRC for Asthma
Project Team Laureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Ming Yang, Dr Simon Phipps
Scheme Research Grant
Role Lead
Funding Start 2005
Funding Finish 2011
GNo G0185860
Type Of Funding CRC - Cooperative Research Centre
Category 4CRC
UON Y

CD4 T cell programming by neonatal and early-life infection$250,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Laureate Professor Paul Foster, Conjoint Professor Kenneth Beagley, Professor Phil Hansbro
Scheme Discovery Projects
Role Lead
Funding Start 2005
Funding Finish 2007
GNo G0184398
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Modulation of inflammatory responses in the asthmatic lung by Chlamydial infection$50,000

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Kenneth Beagley
Scheme Research Grant
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0185208
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

SealSafe Shelving Module IVC System & Slimline AHU Air Control Mobile Trolley$41,449

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster
Scheme Equipment Grant
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0185470
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Chlamydia infection of dendritic cells drives the development of pro-asthmatic Th2 cells$15,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Kenneth Beagley, Laureate Professor Paul Foster
Scheme Project Grant
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0184898
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Prevention of asthma by immunisation with pneumococcal cell walls$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Kenneth Beagley, Conjoint Professor Peter Gibson
Scheme Project Grant
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0184712
Type Of Funding Internal
Category INTE
UON Y

20046 grants / $873,608

Molecular Mechanisms in the Regulation of allergy and inflammation$663,608

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Dr Simon Hogan, Assoc. Prof Klaus Matthaei, Professor Philip Thompson, Professor Ian Young
Scheme Program Grant
Role Lead
Funding Start 2004
Funding Finish 2007
GNo G0184188
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Cytokines regulating airway inflammation, remodelling and hyper-reactivity in chronic asthma$110,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Professor Rakesh Kumar, Dr Mark Raftery
Scheme Project Grant
Role Lead
Funding Start 2004
Funding Finish 2006
GNo G0184155
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Modulation of Asthma by bacterial infection or vaccination in different age groups$60,000

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding body Rebecca L Cooper Medical Research Foundation Ltd
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Kenneth Beagley
Scheme Research Grant
Role Investigator
Funding Start 2004
Funding Finish 2006
GNo G0184154
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Modulation of immune responses in asthma by bacterial infections during early life.$15,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Peter Gibson
Scheme Project Grant
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0183512
Type Of Funding Internal
Category INTE
UON Y

Investigation of the role of eosinophils in regulating disease processes in asthma$15,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Laureate Professor Paul Foster
Scheme New Staff Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0184841
Type Of Funding Internal
Category INTE
UON Y

Chemokine-mediated enhancement of transcutaneous immunization to target genital and respiratory tract chlamydial infections$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Kenneth Beagley, Laureate Professor Paul Foster
Scheme Project Grant
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0183467
Type Of Funding Internal
Category INTE
UON Y
Edit

Research Supervision

Number of supervisions

Completed17
Current17

Total current UON EFTSL

PhD2.55

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2015 PhD Contribution of Cell Death to the Pathogenesis of Chronic Obstructive Pulmonary Disease (COPD)
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Chronic Obstructive Pulmonary Disease (COPD)
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2013 PhD The Impact of Better Asthma Management during Pregnancy on the Lung Function of the Child
PhD (Paediatrics), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2013 PhD Role of TLR/IL-13/STAT6/PI3K Response in Early-life Respiratory Infection and Infection-Induced Chronic Lung Disease
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2013 PhD Investigation of the pathogenesis and potential therapeutic interventions of influenza in Asthma and COPD
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD The Role of Rhinovirus and Novel Molecular Mechanisms in Allergic Airways Disease
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD Investigating the Mechanisms of Tobacco Cigarette Smoke-Induced Lung Cancer
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD The Role of TRAIL in the Induction and Perpetuation of Eosinophilic Oesophagitis
PhD (Paediatrics), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD Roles of Bromodomain and extra terminal (BET) proteins in Suppression of Airway Inflammation
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD Understanding the mechanisms of airway hyper-responsiveness in a mouse model of asthma
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD Assessing the Epigenetic Involvement in the Development and Progression of Chronic Obstructive Pulmonary Disease (COPD)
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2011 PhD The Role of Interferon Epsilon in Protection Against Chlamydial Reproductive Tract Infections
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2011 PhD Mechanisms of Predisposition to Secondary Bacterial Pneumonia
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2011 PhD The Role of Innate Cells in Infectious Exacerbation of COPD
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2011 PhD Immunoregulatory Therapies for Inflammatory Diseases
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2010 PhD Role of TRAIL and TLRT in Response to Rhinovirus Infection in Allergic Airways Disease
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2010 PhD Indentification of New Therapeutics in COPD/ Emphysema
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2016 PhD Investigation of Pathogenesis of Chronic Obstructive Pulmonary Disease
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2016 PhD Role of Fibulin-1 in the Pathogenesis of Chronic Pulmonary Diseases
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2015 PhD Investigation of the Mechanisms of Respiratory Infection- Induced Lung Disease
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2015 PhD Mechanisms of Increased Susceptibility to Influenza Infection in Mouse Models of Chronic Lung Diseases
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Immune Mechanisms that Underpin Early-Life Chlamydia Respiratory Infection-Induced Chronic Lung Disease
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Respiratory Innate Immune Factors Regulate Steroid-resistant Airway Hyperreactivity and Asthma
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD The Role of microRNAs in Allergic Airways Disease and T Cell Biology
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2014 PhD The Role of MicroRNA in Regulating Anti-Bacterial Responses in Innate Immune Cells
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2013 PhD The Role of Early Life Infection on the Programming of CD4+ T-cells
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2012 PhD Modulation of Responses in Allergic Airways Disease by Haemophilus Influenzae Infection
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD Novel Therapeutic Approaches for the Treatment of Allergic Airways Disease
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2011 PhD The Innate Immune Mechanisms Underlying the Interplay Between Respiratory Infections and Asthma
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2011 PhD Understanding the Inflammatory Mechanisms That Predispose to Emphysema in Mouse Models
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2011 PhD Immune Mechanisms that Promote the Development of Inducible Bronchus-Associated Lymphoid Tissue (IBALT)
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2009 PhD Nutritional Modulation of Lung Inflammation
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2008 PhD Modulation of Responses in the Asthmatic Lung by Chlamydial Infection
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2007 PhD Modulation of Responses in the Asthmatic Lung by Streptococcus Pneumoniae
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
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Research Collaborations

The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.

Country Count of Publications
Australia 276
United States 71
United Kingdom 37
Japan 11
Canada 10
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News

PhD scholarship - Regulating exacerbation of asthma and cystic fibrosis

June 20, 2016

A PhD scholarship is available for a student to investigate cellular and molecular mechanisms regulating exacerbation of asthma and cystic fibrosis under the supervision of Dr Hock Tay and Laureate Professor Paul Foster.

Three UON research leaders awarded prestigious fellowship

October 7, 2015

Three University of Newcastle (UON) research leaders are among the distinguished health and medical scientists elected as Fellows of the Australian Academy of Health and Medical Sciences (AAHMS).

Laureate Professor Paul Foster

Warrior immune cells could win the fight against asthma

May 5, 2014

University of Newcastle Laureate Professor Paul Foster is developing new anti-inflammatory approaches to treat asthma and infections of the lung. One promising approach is to boost the body's own defence systems against infections, especially against those that trigger asthma.

Laureate Professor John Aitken

Newcastle biologist named NSW Scientist of the Year

November 14, 2012

The University of Newcastle's Laureate Professor John Aitken has been named NSW Scientist of the Year at the 2012 NSW Science and Engineering awards in Sydney.

Person with asthma inhaler

Laureate Professor awarded top honour from ANU

July 13, 2012

Laureate Professor Paul Foster has been awarded a Doctor of Science degree (D.Sc.) from the Australian National University at a ceremony on Friday July 13th, 2012. This is a particularly prestigious award given the Australian National University is ranked as one of the top 50 Universities in the world.

Laureate Professor Paul Foster

Position

Laureate Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Immunology and Microbiology

Contact Details

Email paul.foster@newcastle.edu.au
Phone (02) 4042 0163
Fax (02) 4042 0036

Office

Room 2401 HMRI
Building HMRI
Location Other

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