Mrs Nisha Panth

Mrs Nisha Panth

Research student

Career Summary

Biography

Nisha Panth is a PhD researcher from the Nutraceuticals Research Program. She is currently working on dietary fats and its impact on cardiovascular risk factors. 

Keywords

  • Cell culture, Animal handling
  • Organ Chamber Assay, Western Blot

Languages

  • Nepali (Mother)
  • English (Fluent)

Fields of Research

Code Description Percentage
111501 Basic Pharmacology 100
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (8 outputs)

Year Citation Altmetrics Link
2020 Panth N, Dias CB, Wynne K, Singh H, Garg ML, 'Medium-chain fatty acids lower postprandial lipemia: A randomized crossover trial', Clinical Nutrition, 39 90-96 (2020)

© 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Epidemiological and interventional studies have linked saturated fatty acids (SFA) with elevated lev... [more]

© 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Epidemiological and interventional studies have linked saturated fatty acids (SFA) with elevated levels of low-density lipoprotein cholesterol (LDL-C) and increased CVD risk. However, the effects of the SFA chain length on postprandial lipemia in humans are not well elucidated. The aim of this study was to investigate the impact of short, medium and long-chain SFA on postprandial blood lipids in healthy volunteers. Sixteen healthy volunteers consumed test biscuits containing 40 g of either butter (BB), coconut oil (CB) or lard (LB) in a single-blinded, randomized crossover design. Blood samples were collected fasting and 2, 3, 4, and 6 hours postprandially and assessed for blood lipids (total cholesterol, TC; high-density lipoprotein cholesterol, HDL-C; LDL-C and triglyceride, TG). The postprandial TG response following CB was 59.8% lower than following BB (p < 0.01) and 58.8% lower than LB (p < 0.01), although no difference was observed between the BB and the LB responses. The net area under the LDL-C concentration curve was significantly larger after consumption of the CB compared to the BB, despite no significant differences in postprandial net area under the TC and HDL-C concentration curves. Consumption of medium-chain SFA as CB resulted in lower postprandial TG excursions compared to short-chain SFA as BB and long-chain SFA as LB, despite their identical fat and caloric content. These results suggest that SFA differ in their potential to elevate postprandial lipid levels, and that coconut oil, a rich source of medium-chain SFA may not be as hyperlipidemic as animal fats rich in long chain SFA. Anzctr identifier: 12617000903381. Clinical trial registry number: The study was registered with the Australia New Zealand Trial registry as ACTRN12617000903381.

DOI 10.1016/j.clnu.2019.02.008
Citations Scopus - 2Web of Science - 5
Co-authors Manohar Garg, Katie-Jane Wynne
2018 Panth N, Abbott KA, Dias CB, Wynne K, Garg ML, 'Differential effects of medium- and long-chain saturated fatty acids on blood lipid profile: A systematic review and meta-analysis', American Journal of Clinical Nutrition, 108 675-687 (2018) [C1]

© 2018 American Society for Nutrition. Background Medium-chain saturated fatty acids (MCFAs) may affect circulating lipids and lipoproteins differently than long-chain saturated f... [more]

© 2018 American Society for Nutrition. Background Medium-chain saturated fatty acids (MCFAs) may affect circulating lipids and lipoproteins differently than long-chain saturated fatty acids (LCSFAs), but the results from human intervention trials have been equivocal. Objective The aim of this study was to determine whether MCFAs and LCSFAs have differential impacts on blood lipids and lipoproteins. Design Five databases were searched (EMBASE, MEDLINE, CINAHL, Cochrane, and Scopus) until April 2018, and published clinical trials investigating the differential effects of dietary MCFAs and LCSFAs on blood lipids were included. Searches were limited to the English language and to studies with adults aged >18 y. Where possible, studies were pooled for meta-analysis using RevMan 5.2. The principle summary measure was the mean difference between groups calculated using the random-effects model. Results Eleven eligible crossover and 1 parallel trial were identified with a total of 299 participants [weighted mean ± SD age: 38 ± 3 y; weighted mean ± SD body mass index (kg/m 2): 24 ± 2]. All studies were pooled for the meta-analysis. Diets enriched with MCFAs led to significantly higher high-density lipoprotein (HDL) cholesterol concentrations than diets enriched with LCSFAs (0.11 mmol/L; 95% CI: 0.07, 0.15 mmol/L) with no effect on triglyceride, low-density lipoprotein (LDL) cholesterol, and total cholesterol concentrations. Consumption of diets rich in MCFAs significantly increased apolipoprotein A-I (apoA-I) concentrations compared with diets rich in LCSFAs (0.08 g/L; 95% CI: 0.02, 0.14 g/L). There was no evidence of statistical heterogeneity for HDL cholesterol, apoA-I, and triglyceride concentrations; however, significant heterogeneity was observed for the total cholesterol (I 2 = 49%) and LDL cholesterol analysis (I 2 = 58%). Conclusion The findings of this research demonstrate a differential effect of MCFAs and LCSFAs on HDL cholesterol concentrations. Further investigations are warranted to elucidate the mechanism by which the lipid profile is altered. This trial was registered at www.crd.york.ac.uk/PROSPERO as CRD42017078277.

DOI 10.1093/ajcn/nqy167
Citations Scopus - 6Web of Science - 6
Co-authors Katie-Jane Wynne, Manohar Garg
2018 Panth N, Paudel KR, Gong D-S, Oak M-H, 'Vascular Protection by Ethanol Extract of Morus alba Root Bark: Endothelium-Dependent Relaxation of Rat Aorta and Decrease of Smooth Muscle Cell Migration and Proliferation', EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, (2018)
DOI 10.1155/2018/7905763
Citations Scopus - 1Web of Science - 1
2017 Panth N, Manandhar B, Paudel KR, 'Anticancer Activity of Punica granatum (Pomegranate): A Review', PHYTOTHERAPY RESEARCH, 31 568-578 (2017)
DOI 10.1002/ptr.5784
Citations Scopus - 36Web of Science - 35
2016 Panth N, Park S-H, Kim HJ, Kim D-H, Oak M-H, 'Protective Effect of Salicornia europaea Extracts on High Salt Intake-Induced Vascular Dysfunction and Hypertension', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 17 (2016)
DOI 10.3390/ijms17071176
Citations Scopus - 6Web of Science - 7
2016 Panth N, Paudel KR, Parajuli K, 'Reactive Oxygen Species: A Key Hallmark of Cardiovascular Disease.', Advances in medicine, 2016 9152732 (2016)
DOI 10.1155/2016/9152732
2016 Panth N, 'Protective effect of Salicornia europaea extracts on high salt intake-induced vascular dysfunction and hypertension.', International Journal of Molecular Sciences, (2016)
2015 Paudel KR, Panth N, 'Phytochemical Profile and Biological Activity of Nelumbo nucifera', EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, (2015)
DOI 10.1155/2015/789124
Citations Scopus - 44Web of Science - 33
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Mrs Nisha Panth

Contact Details

Email nisha.panth@uon.edu.au
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