Dr Michael Bourke

Dr Michael Bourke

Lecturer

School of Biomedical Sciences and Pharmacy

Looking ahead to an exceptional student experience

Video: Dr Michael Bourke

Looking ahead to an exceptional student experience

Dr Michael Bourke talks about his passion for seeing students learn and reach their full potential.

Read more

Career Summary

Biography

I completed my PhD at the University of Sydney, Australia in 2014. During my time in the Systems Neuroscience Laboratory of Dr Atomu Sawatari I investigated roles for the novel family of type II transmembrane glycoproteins, the teneurins, in the development of the limbic and visual systems of mice. This work showed that the teneurins are expressed in topographically related gradients throughout the hippocampal formation and related cortical regions, such as the entorhinal cortex, and subcortical regions, such as the mammillary bodies and anterior nuclei of the thalamus, as well as throughout topographically interconnected regions of the visual system. Using knockout models, I demonstrated that these proteins are required for the normal developmental interconnectivity of these regions and that targeted deletion of these genes results in visuospatial learning and memory deficits in vivo.

Following my PhD I undertook a post-doctoral fellowship with the Queensland Research Centre for Peripheral Vascular Disease (QRC-PVD) and the Vascular Biology Unit (VBU) at James Cook University, led by Professor Jonathan Golledge. During this post-doctoral research I established a clinical trial research centre on the Central Coast of New South Wales, in collaboration with Gosford Vascular Services. I am investigating novel medical therapies to slow the progression of abdominal aortic aneurysm (AAA) and have established a peripheral vascular biobank to understand the genetic nuances of vascular diseases, including aortic aneurysm, carotid atherosclerosis and lower limb occlusive disease. One outcome from this ongoing research collaboration was the discovery that the diabetes drug metformin is associated with slower growth rates of aortic aneurysms as well as a with a reduced incidence of surgical repair and rupture related mortality in patients with AAA.

In 2020 I was awarded a lectureship in the School of Biomedical Sciences and Pharmacy at The University of Newcastle. Here I am expanding my clinical research across the Central Coast Local Health District and the Hunter New England Local Health District to investigate novel treatments for vascular diseases. Together with the QRC-PVD, and The Georges Institute for Global Health in Sydney, I was awarded a $4.9 million NHMRC grant to initiate the world's largest ever prospective clinical trial on AAA in a hope to discover the world's first ever medical treatment for this disorder that kills over 2000 Australians anually. I am  working in collaboration with Professor Nicholas Goodwin, Director of the Central Coast Research Institute, to develop novel integrative approaches to understand and manage vascular disease. I am also in collaboration with Professor Manohar Garg, leader of the Clinical and Experimental Nutrition theme at the Priority Research Centre for Physical Activity and Nutrition (PRCPAN) at the University of Newcastle, to investigate potential roles of fatty acids in the pathogenesis of aneurysms.

I am an experienced lecturer in the fields of anatomy and cardiovascular pathophysiology and have taught into multiple medical programs at Australian universities for over a decade. My teaching was acknowledged by an award for teaching excellence from the University of Sydney and I am leading the establishment of biomedical science teaching into the newly created Central Coast Clinical School based at Gosford Hospital.

In conjunction with multiple Health Districts across New South Wales, I am leading and delivering a pilot of applied anatomical training for junior surgeons and radiologists to improve the anatomical knowledge in this area and to develop partnerships between the university and our industry and health partners.


Qualifications

  • Doctor of Philosophy, University of Sydney
  • Bachelor of Medical Science (Honours), University of Sydney

Keywords

  • Abdominal aortic aneurysm (AAA)
  • Angiogenesis
  • Carotid endarterectomy
  • Clinical trials
  • Endothelium
  • Pericyte
  • Peripheral vascular disease (PVD)
  • Vascular Endothelial Growth Factor (VEGF)
  • Vascular smooth muscle

Languages

  • English (Mother)
  • Spanish (Working)

Professional Experience

UON Appointment

Title Organisation / Department
Lecturer University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
Lecturer University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Professional appointment

Dates Title Organisation / Department
1/1/2014 - 1/1/2018 Postdoctoral fellow James Cook University
School of Public Health Medicine and Rehabilitation Sciences
Australia
1/1/2018 - 1/1/2022 Clinical Research Associate Gosford Vascular Services
Australia

Teaching

Code Course Role Duration
PDTY2103 Advanced Lower Limb Anatomy
Faculty of Health and Medicine, University of Newcastle
Lecturer 1/1/2021 - 31/12/2021
MEDI1101a Medicine year 1
Faculty of Health and Medicine, The University of Newcastle
Lecture 1/1/2021 - 31/12/2021
HUBS2505 Human Pathophysiology
Faculty of Health and Medicine, The University of Newcastle
Lecturer 1/1/2021 - 31/12/2021
MEDI1101b Medicine year 1
Faculty of Health and Medicine, The University of Newcastle
Lecturer 1/1/2021 - 31/12/2021
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (10 outputs)

Year Citation Altmetrics Link
2020 Golledge J, Rowbotham S, Velu R, Quigley F, Jenkins J, Bourke M, et al., 'Association of Serum Lipoprotein (a) With the Requirement for a Peripheral Artery Operation and the Incidence of Major Adverse Cardiovascular Events in People With Peripheral Artery Disease', JOURNAL OF THE AMERICAN HEART ASSOCIATION, 9 (2020)
DOI 10.1161/JAHA.119.015355
Citations Web of Science - 1
2019 Golledge J, Morris DR, Pinchbeck J, Rowbotham S, Jenkins J, Bourke M, et al., 'Editor's Choice - Metformin Prescription is Associated with a Reduction in the Combined Incidence of Surgical Repair and Rupture Related Mortality in Patients with Abdominal Aortic Aneurysm', EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, 57 94-101 (2019)
DOI 10.1016/j.ejvs.2018.07.035
Citations Scopus - 13Web of Science - 15
2019 Manapurathe DT, Moxon JV, Krishna SM, Rowbotham S, Quigley F, Jenkins J, et al., 'Cohort Study Examining the Association Between Blood Pressure and Cardiovascular Events in Patients With Peripheral Artery Disease', JOURNAL OF THE AMERICAN HEART ASSOCIATION, 8 (2019)
DOI 10.1161/JAHA.118.010748
Citations Scopus - 8Web of Science - 9
2018 Pinchbeck JL, Moxon JV, Rowbotham SE, Bourke M, Lazzaroni S, Morton SK, et al., 'Randomized Placebo-Controlled Trial Assessing the Effect of 24-Week Fenofibrate Therapy on Circulating Markers of Abdominal Aortic Aneurysm: Outcomes From the FAME-2 Trial', JOURNAL OF THE AMERICAN HEART ASSOCIATION, 7 (2018)
DOI 10.1161/JAHA.118.009866
Citations Scopus - 12Web of Science - 12
2017 Golledge J, Moxon J, Pinchbeck J, Anderson G, Rowbotham S, Jenkins J, et al., 'Association between metformin prescription and growth rates of abdominal aortic aneurysms', BRITISH JOURNAL OF SURGERY, 104 1486-1493 (2017)
DOI 10.1002/bjs.10587
Citations Scopus - 33Web of Science - 31
2017 Rowbotham SE, Pinchbeck JL, Anderson G, Bourke B, Bourke M, Gasser TC, et al., 'Inositol in the MAnaGemENt of abdominal aortic aneurysm (IMAGEN): study protocol for a randomised controlled trial', TRIALS, 18 (2017)
DOI 10.1186/s13063-017-2304-x
Citations Scopus - 1Web of Science - 1
2016 Morris DR, Cunningham MA, Ahimastos AA, Kingwell BA, Pappas E, Bourke M, et al., 'Erratum to: 'TElmisartan in the management of abDominal aortic aneurYsm (TEDY): The study protocol for a randomized controlled trial' [Trials, (2016), 17:43]', Trials, 17 (2016)
DOI 10.1186/s13063-016-1183-x
Citations Scopus - 1
2015 Morris DR, Cunningham MA, Ahimastos AA, Kingwell BA, Pappas E, Bourke M, et al., 'TElmisartan in the management of abDominal aortic aneurYsm (TEDY): The study protocol for a randomized controlled trial', Trials, 16 (2015)

© 2015 Morris et al. Background: Experimental studies suggest that angiotensin II plays a central role in the pathogenesis of abdominal aortic aneurysm. This trial aims to evaluat... [more]

© 2015 Morris et al. Background: Experimental studies suggest that angiotensin II plays a central role in the pathogenesis of abdominal aortic aneurysm. This trial aims to evaluate the efficacy of the angiotensin receptor blocker telmisartan in limiting the progression of abdominal aortic aneurysm. Methods/Design: Telmisartan in the management of abdominal aortic aneurysm (TEDY) is a multicentre, parallel-design, randomised, double-blind, placebo-controlled trial with an intention-to-treat analysis. We aim to randomly assign 300 participants with small abdominal aortic aneurysm to either 40 mg of telmisartan or identical placebo and follow patients over 2 years. The primary endpoint will be abdominal aortic aneurysm growth as measured by 1) maximum infra-renal aortic volume on computed tomographic angiography, 2) maximum orthogonal diameter on computed tomographic angiography, and 3) maximum diameter on ultrasound. Secondary endpoints include change in resting brachial blood pressure, abdominal aortic aneurysm biomarker profile and health-related quality of life. TEDY is an international collaboration conducted from major vascular centres in Australia, the United States and the Netherlands. Discussion: Currently, no medication has been convincingly demonstrated to limit abdominal aortic aneurysm progression. TEDY will examine the potential of a promising treatment strategy for patients with small abdominal aortic aneurysms. Trial registration: Australian and Leiden study centres: Australian New Zealand Clinical Trials Registry ACTRN12611000931976, registered on 30 August 2011; Stanford study centre: clinicaltrials.gov NCT01683084, registered on 5 September 2012.

DOI 10.1186/s13063-015-0793-z
Citations Scopus - 24Web of Science - 25
2013 Young TR, Bourke M, Zhou X, Oohashi T, Sawatari A, Faessler R, Leamey CA, 'Ten-m2 Is Required for the Generation of Binocular Visual Circuits', JOURNAL OF NEUROSCIENCE, 33 12490-+ (2013)
DOI 10.1523/JNEUROSCI.4708-12.2013
Citations Web of Science - 43
2009 Simonetti T, Lee H, Bourke M, Leamey CA, Sawatari A, 'Enrichment from Birth Accelerates the Functional and Cellular Development of a Motor Control Area in the Mouse', PLOS ONE, 4 (2009)
DOI 10.1371/journal.pone.0006780
Citations Web of Science - 26
Show 7 more journal articles
Edit

Dr Michael Bourke

Position

Lecturer
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing

Contact Details

Email michael.d.bourke@newcastle.edu.au
Mobile 0432045972
Edit