| 2020 |
Qiao Y, Maiti K, Sultana Z, Fu L, Smith R, 'Inhibition of vertebrate aldehyde oxidase as a therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis', European Journal of Medicinal Chemistry, 187 (2020) [C1]
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| 2018 |
Sultana Z, Maiti K, Dedman L, Smith R, 'Is there a role for placental senescence in the genesis of obstetric complications and fetal growth restriction?', American Journal of Obstetrics and Gynecology, 218 S762-S773 (2018) [C1]
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| 2017 |
Maiti K, Sultana Z, Aitken RJ, Morris J, Park F, Andrew B, et al., 'Evidence that fetal death is associated with placental aging.', American journal of obstetrics and gynecology, 217 441.e1-441.e14 (2017) [C1]
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| 2017 |
Sultana Z, Maiti K, Aitken J, Morris J, Dedman L, Smith R, 'Oxidative stress, placental ageing-related pathologies and adverse pregnancy outcomes', AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 77 (2017) [C1]
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| 2016 |
De Sousa SMC, Maiti K, Smith R, McCormack AI, 'Corticotrophin-releasing hormone (CRH) expression in the dermoid component of ovarian teratomas', JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 30 867-869 (2016)
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| 2014 |
Parkington HC, Stevenson J, Tonta MA, Paul J, Butler T, Maiti K, et al., 'Diminished hERG K
Human ether-a-go-go-related gene (hERG) potassium channels determine cardiac action potential and contraction duration. Human uterine contractions are underpinned by an action pot... [more] Human ether-a-go-go-related gene (hERG) potassium channels determine cardiac action potential and contraction duration. Human uterine contractions are underpinned by an action potential that also possesses an initial spike followed by prolonged depolarization. Here we show that hERG channel proteins (a-conducting and ßinhibitory subunits) and hERG currents exist in isolated patch-clamped human myometrial cells. We show that hERG channel activity suppresses contraction amplitude and duration before labour, thereby facilitating quiescence. During established labour, expression of ß-inhibitory protein is markedly enhanced, resulting in reduced hERG activity that is associated with an increased duration of uterine action potentials and contractions. Thus, changes in hERG channel activity contribute to electrophysiological mechanisms that produce contractions during labour. We also demonstrate that this system fails in women with elevated BMI, who have enhanced hERG activity as a result of low ß-inhibitory protein expression, which likely contributes to the weak contractions and poor labour outcomes observed in many obese women necessitating caesarean delivery. © 2014 Macmillan Publishers Limited.
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| 2014 |
Chai SY, Smith R, Fitter JT, Mitchell C, Pan X, Ilicic M, et al., 'Increased progesterone receptor a expression in labouring human myometrium is associated with decreased promoter occupancy by the histone demethylase JARID1A', Molecular Human Reproduction, 20 442-453 (2014) [C1]
Progesterone regulates female reproductive function predominantly through two nuclear progesterone receptors (PRs), PR-A and PR-B. During human parturition myometrial PR expressio... [more] Progesterone regulates female reproductive function predominantly through two nuclear progesterone receptors (PRs), PR-A and PR-B. During human parturition myometrial PR expression is altered to favour PR-A, which activates pro-labour genes. We have previously identified histone H3 lysine 4 trimethylation (H3K4me3) as an activator of myometrial PR-A expression at labour. To further elucidate the mechanisms regulating PR isoform expression in the human uterus at labour, we have (i) determined the methylation profile of the cytosine-guanine dinucleotides (CpG) island in the promoter region of the PR gene and (ii) identified the histone-modifying enzymes that target the H3K4me3 mark at the PR promoters in term and preterm human myometrial tissues obtained before and after labour onset. Bisulphite sequencing showed that despite overall low levels of PR CpG island methylation, there was a significant decrease in methylated CpGs with labour in both preterm (P < 0.05) and term (P < 0.01) groups downstream of the PR-B transcription start site. This methylation change was not associated with altered PR-B expression, but may contribute to the increase in PR-A expression with labour. Chromatin immunoprecipitation revealed that the histone methyltransferase, SET and MYND domain-containing protein 3 (SMYD3), bound to the PR gene at significantly higher levels at the PR-A promoter compared with the PR-B promoter (P < 0.010), with no labour-associated changes observed. The H3K4 demethylase, Jumonji AT-rich interactive domain 1A (JARID1A), also bound to the PR-A, but not to the PR-B promoter prior to term labour, and decreased significantly at the onset of labour (P = 0.014), providing a mechanism for the previously reported increase in H3K4me3 level and PR-A expression with labour. Our studies suggest that epigenetic changes mediated by JARID1A, SMYD3 and DNA methylation may be responsible, at least in part, for the functional progesterone withdrawal that precipitates human labour. © The Author 2014. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
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| 2013 |
Smith R, Maiti K, Aitken RJ, 'Unexplained antepartum stillbirth: A consequence of placental aging?', PLACENTA, 34 310-313 (2013) [C3]
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| 2013 |
Chen Y, Allars M, Pan X, Maiti K, Angeli G, Smith R, Nicholson RC, 'Effects of corticotrophin releasing hormone (CRH) on cell viability and differentiation in the human BeWo choriocarcinoma cell line: a potential syncytialisation inducer distinct from cyclic adenosine monophosphate (cAMP)', REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 11 (2013) [C1]
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| 2012 |
Smith R, Maiti K, 'The placenta, a transducer linking maternal nutrition to adult disease in the offspring?', Endocrinology, 153 1572-1574 (2012) [C3]
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| 2012 |
Tolosa Gonzalez JM, Schjenken JE, Clifton VL, Vargas A, Barbeau B, Lowry P, et al., 'The endogenous retroviral envelope protein syncytin-1 inhibits LPS/PHA-stimulated cytokine responses in human blood and is sorted into placental exosomes', Placenta, 33 933-941 (2012) [C1]
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| 2012 |
Smith R, Paul JW, Maiti K, Tolosa Gonzalez JM, Madsen GM, 'Recent advances in understanding the endocrinology of human birth', Trends in Endocrinology & Metabolism, 23 516-523 (2012) [C1]
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| 2011 |
Paul JW, Maiti K, Read MA, Hure AJ, Smith JI, Chan EC, Smith R, 'Phasic phosphorylation of caldesmon and ERK 1/2 during contractions in human myometrium', PLoS ONE, 6 1-7 (2011) [C1]
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| 2011 |
Maiti K, Paul JW, Read MA, Chan EC, Riley SC, Nahar P, Smith R, 'G-1-activated membrane estrogen receptors mediate increased contractility of the human myometrium', Endocrinology, 152 2448-2455 (2011) [C1]
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| 2011 |
Chen Y, Allars MJ, Maiti K, Angeli GL, Abou-Seif C, Smith R, Nicholson RC, 'Factors affecting cytotrophoblast cell viability and differentiation: Evidence of a link between syncytialisation and apoptosis', International Journal of Biochemistry & Cell Biology, 43 821-828 (2011) [C1]
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| 2009 |
Kim D-K, Yang JS, Maiti K, Hwang J-I, Kim K, Seen D, et al., 'A Gonadotropin-Releasing Hormone-II Antagonist Induces Autophagy of Prostate Cancer Cells', CANCER RESEARCH, 69 923-931 (2009) [C1]
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| 2008 |
Wang C, Oh DY, Maiti K, Kwon HB, Cheon J, Hwang JI, Seong JY, 'Involvement of amino acids flanking Glu
The Glu/Asp residue in extracellular loop 3 of the mammalian type-I gonadotropin-releasing hormone receptor (GnRHR) interacts with Arg of GnRH-I, conferring preferential ligand ... [more] The Glu/Asp residue in extracellular loop 3 of the mammalian type-I gonadotropin-releasing hormone receptor (GnRHR) interacts with Arg of GnRH-I, conferring preferential ligand selectivity for GnRH-I over GnRH-II. Previously, we demonstrated that the residues (Ser and Pro) flanking Glu/Asp also play a role in the differential agonist selectivity of mammalian and non-mammalian GnRHRs. In this study, we examined the differential antagonist selectivity of wild type and mutant GnRHRs in which the Ser and Pro residues were changed. Cetrorelix, a GnRH-I antagonist, and Trptorelix-2, a GnRH-II antagonist, exhibited high selectivity for mammalian type-I and non-mammalian GnRHRs, respectively. The inhibitory activities of the antagonists were dependent on agonist concentration and subtype. Rat GnRHR in which the Ser-Glu-Pro (SEP) motif was changed to Pro-Glu-Val (PEV) or Pro-Glu-Ser (PES) had increased sensitivity to Trptorelix-2 but decreased sensitivity to Cetrorelix. Mutant bullfrog GnRHR-1 with the SEP motif had the reverse antagonist selectivity, with redueed sensitivity to Trptorelix-2 but increased sensitivity to Cetrorelix. These findings indicate that the residues flanking Glu are important for antagonist as well as agonist selectivity. © KSMCB 2008. 7.32 8 7.32 7.32
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| 2007 |
Eid AH, Maiti K, Mitra S, Chotani MA, Flavahan S, Bailey SR, et al., 'Estrogen increases smooth muscle expression of alpha(2C)-adrenoceptors and cold-induced constriction of cutaneous arteries', AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 293 H1955-H1961 (2007)
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| 2005 |
Maiti K, Oh DY, Moon JS, Acharjee S, Li JH, Bai DG, et al., 'Differential effects of gonadotropin-releasing hormone (GnRH)-I and GnRH-II on prostate cancer cell signaling and death', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 90 4287-4298 (2005)
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| 2005 |
Li JH, Choe H, Wang AF, Maiti K, Wang CB, Salam A, et al., 'Extracellular loop 3 (EL3) and EL3-proximal transmembrane helix 7 of the mammalian type I and type II gonadotropin-releasing hormone (GnRH) receptors determine differential ligand selectivity to GnRH-I and GnRH-II', MOLECULAR PHARMACOLOGY, 67 1099-1110 (2005)
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| 2004 |
Wang CB, Yun O, Maiti K, Oh DY, Kim KK, Chae CH, et al., 'Position of pro and Ser near Glu(7.32) in the extracellular loop 3 of mammalian and nonmammalian gonadotropin-releasing hormone (GnRH) receptors is a critical determinant for differential ligand selectivity for mammalian GnRH and chicken GnRH-II', MOLECULAR ENDOCRINOLOGY, 18 105-116 (2004)
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| 2003 |
Maiti K, Li J, Wang AF, Acharjee S, Kim WP, Im WB, et al., 'GnRH-II analogs for selective activation and inhibition of non-mammalian and type-II mammalian GnRH receptors.', Molecules and cells, 16 173-179 (2003)
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| 2003 |
Seong JY, Wang L, Oh DY, Yun O, Maiti K, Li JH, et al., 'Ala/Thr(201) in extracellular loop 2 and Leu/Phe(290) in transmembrane domain 6 of type 1 frog gonadotropin-releasing hormone receptor confer differential ligand sensitivity and signal transduction', ENDOCRINOLOGY, 144 454-466 (2003)
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| 2003 |
Wang AF, Li JH, Maiti K, Kim WP, Kang HM, Seong JY, Kwon HB, 'Preferential ligand selectivity of the monkey type-II gonadotropin-releasing hormone (GnRH) receptor for GnRH-2 and its analogs', MOLECULAR AND CELLULAR ENDOCRINOLOGY, 209 33-42 (2003)
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| 2002 |
Acharjee S, Maiti K, Soh JM, Im WB, Seong JY, Kwon HB, 'Differential desensitization and internalization of three different bullfrog gonadotropin-releasing hormone receptors', Molecules and Cells, 14 101-107 (2002)
We previously demonstrated the presence of three distinct types of the gonadotropin-releasing hormone receptor (GnRHR) in a bullfrog (denoted bfGnRHR-1, bfGnRHR-2, and bfGnRHR-3).... [more] We previously demonstrated the presence of three distinct types of the gonadotropin-releasing hormone receptor (GnRHR) in a bullfrog (denoted bfGnRHR-1, bfGnRHR-2, and bfGnRHR-3). The bfGnRHRs exhibited differential tissue distribution and ligand selectivity. In the present study, we demonstrated the desensitization and internalization kinetics of these receptors in both transiently-transfected HEK293 cells and retrovirus-mediated stable cells. The time-course accumulation of the inositol phosphate in response to GnRH revealed that bfGnRHR-1 and -2 were rapidly desensitized, whereas bfGnRHR-3 was slowly desensitized. A comparison of the internalization kinetics revealed the most rapid rate and highest extent of internalization of bfGnRHR-2 among the three receptors. Interestingly, the mechanisms that underlie the receptor internalization appear to differ from each other. Internalization of bfGnRHR-1 was dependent on both dynamin and ß-arrestin, whereas those of bfGnRHR-2 and -3 were dependent on dynamin, but not on ß-arrestin. These results, therefore, suggest that differential regulatory mechanisms for desensitization and internalization of the GnRHR are involved in diverse cellular and physiological responses to GnRH stimulation. ©KSMCB 2002.
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| 2001 |
Chattopadhyay D, Maiti K, Kundu AP, Chakraborty MS, Bhadra R, Mandal SC, Mandal AB, 'Antimicrobial activity of Alstonia macrophylla: a folklore of bay islands', JOURNAL OF ETHNOPHARMACOLOGY, 77 49-55 (2001)
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