Dr Isabel Huey Sien Chew

Dr Isabel Huey Sien Chew

Postdoctoral Research Associate

School of Biomedical Sciences and Pharmacy

Career Summary

Biography

Dr. Isabel Chew’s journey in neuroscience is fueled by a passion for understanding the neurobiology of mental health, particularly obsessive-compulsive disorder (OCD). In 2024 she completed her PhD with Prof. Christopher Dayas and Dr. Lizzie Manning at the University of Newcastle investigating the involvement of striatal neurons in behavioural inflexibility characteristic of cocaine-use disorders.

This work explored the role that spiny projection neurons in the dorsal striatum played in the transition from goal-directed behaviour to more rigid, habit-like responding for rewards. Using neuroimaging technology, Isabel aimed to record from the two populations of neurons that form the vast majority (~95%) of the cells in the striatum to understand how they compete/cooperate with each other to guide decision-making and behaviour.  

Since then, she’s transitioned to her role as a postdoctoral researcher under the leadership of Dr. Lizzie Manning exploring striatal contributions to different aspects of inflexible behaviour in a transgenic mouse model of OCD. Using cutting-edge miniature microscopes, her research aims to clarify the neural mechanisms underpinning inflexible behaviors relevant to OCD, shedding light on a poorly understood disorder.

Global research directions

Growing up in Malaysia where mental health is heavily stigmatised, Dr. Chew witnessed firsthand the suffering of individuals with untreated OCD. This experience ignited her determination to unravel the mysteries of mental health from a neurobiological perspective. She was awarded a full scholarship to pursue her undergraduate studies at the University of Cambridge in Natural Sciences, where her interests led her to pursue psychology, neuroscience, and behavioral sciences. During this time, she did a summer internship with Prof. David Belin, where she had her first exposure to behavioural neuroscience applied to addiction research. She carried out the schedule-induced polydipsia task which was a measure of compulsive coping behaviour in rats, of which her contributions were acknowledged in their Neuropsychopharmacology paper (https://www.nature.com/articles/s41386-022-01522-y)

Alongside this, she was motivated by her desire to understand OCD, leading her to propose and write her own undergraduate dissertation with Prof. Trevor Robbins titled ‘the Aetiology of OCD’. Prior to starting her PhD in Australia, she received the ISTernship  scholarship (https://phd.pages.ist.ac.at/isternship/) to spend 3 months at the Institute of Science and Technology in Austria with Prof. Gaia Novarino, where she trained in molecular techniques applied to Autism.

Dr. Isabel Chew’s experiences in both life and research has led her to where she is today, and she is grateful for the opportunity to be working on a condition so close to her heart.  She hopes that her research will not only combat societal stigma but also to translate into improved treatment strategies and greater compassion for those grappling with OCD.


Qualifications

  • Doctor of Philosophy, University of Newcastle
  • Bachelor of Arts, University of Cambridge - UK

Keywords

  • Behavioural Inflexibility
  • Behavioural Science
  • Disordered Behaviours
  • Mental Health
  • Neurobiology
  • Neuroimaging
  • Neuroscience
  • OCD
  • Obsessive-Compulsive Disorder
  • Psychology

Languages

  • English (Mother)
  • Mandarin (Fluent)
  • Malay (Fluent)

Fields of Research

Code Description Percentage
520202 Behavioural neuroscience 50
320903 Central nervous system 50

Professional Experience

UON Appointment

Title Organisation / Department
Postdoctoral Research Associate University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Teaching

Code Course Role Duration
PSYC1000 Introductory Research Methods in Psychology
School of Psychological Sciences, College of Engineering, Science and Environment, University of Newcastle
Academic Tutor 
Academic Tutor - Psychology 1/1/2021 - 31/12/2023
PSYC3301 Advanced Perception and Learning in Psychology
School of Psychological Sciences, College of Engineering, Science and Environment, University of Newcastle
Tutor 1/1/2022 - 30/6/2022
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Conference (1 outputs)

Year Citation Altmetrics Link
2023 Stanton L, Mitchell C, Campbell E, Iredale J, Chew I, Burton N, Dayas C, Manning E, 'Impairment of Reward Processing Behaviours Relevant to Depression is Regulated by the Activity of Hypothalamic Corticotrophin-Releasing Hormone Neurons', NEUROPSYCHOPHARMACOLOGY, 48, 283-283 (2023)
Co-authors Caitlin Mitchell, Christopher Dayas
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Dr Isabel Huey Sien Chew

Position

Postdoctoral Research Associate
DAYAS / MANNING Lab.
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing

Contact Details

Email isabelhueysien.chew@newcastle.edu.au
Mobile 0422158288

Office

Room A119
Building Architecture
Location Callaghan Campus
University Drive
Callaghan, NSW 2308
Australia
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