Dr Aniruddh Deshpande
Conjoint Senior Lecturer
School of Medicine and Public Health
- Phone:Enter in format (02) 49213386
Dr Aniruddh Deshpande is a Paediatric Urologist and Surgeon at John Hunter Children’s Hospitaland also a Clinician Researcher in the Priority Research Centre GrowUpWell with research interests in urinary, kidney and bladder diseases in children, consumer perspectives and evolving targeted and better treatment and support strategies for medical and social morbidity in rare surgical diseases in children. Dr Deshpande is one of two paediatric urologists working in Hunter New England Local Health District and has established the tertiary paediatric urinary continence service, which includes a multidisciplinary team.
Dr Deshpande has built a successful track record in paediatric surgical/urological research while furthering the understanding and many aspects of treatment of urinary incontinence in children. He has gained recognition for his work on urinary incontinence in children including cognizance of consumer perspectives in developing treatment strategies. His work through Cochrane reviews directly informs clinical practice and my work on the terminology adaptation formed the basis of the 2014 update by the International Children’s Continence Society. His formal training in Clinical Epidemiology especially systematic reviews enables him to advocate for formal high-level research in surgical specialties. This has resulted in invitations as an Invited Speaker on issues related to his specialty as well as thematic sessions on Surgical Research.
Top 5 publications in the last 5 years
Deshpande AV , Caldwell PH, Sureshkumar P. Drugs for nocturnal enuresis in children (other than desmopressin and tricyclics).Cochrane Database Syst Rev. 2012 Dec 12;12:CD002238. The findings were the first level 1 evidence to advocate for combination therapy for nonmonosymptomatic nocturnal enuresis.
- Deshpande AV. Current strategies to predict and manage sequelae of posterior urethral valves in children. Pediatr Nephrol. 2017 Nov 20. doi: 10.1007/s00467-017-3815-0. [Epub ahead of print] PubMed PMID: 29159472.
- Deshpande AV, Craig JC, Smith GHH, Caldwell PHY. Factors influencing quality of life in children with urinary incontinence. J Urol 2011; 186(3): 1048-52. Also published in Urotoday and Nursing review Online. This study was the first to identify patient characteristics which are associated with more severe negative impacts on quality of life of children with urinary incontinence as perceived by the children themselves. The findings have received widespread acceptance and have informed significant change in support strategies.
- Al Saywid B, Saleh H, Deshpande AV, Howman-Giles R, Smith GHH. High Grade Primary Vesicoureteral Reflux in Boys: Long Term Results of a Prospective Cohort Study. J Urol, 2010, 184: 1598-1603. One of the largest prospective cohort studies to confirm the efficacy of circumcision (compared to antibiotics or major surgery) in preventing kidney scarring in boys with high grade vesicoureteric reflux.
- Jude E, Deshpande A, Barker A, Khosa J, Samnakay N. Intravesical ureteric reimplantation for primary obstructed megaureter in infants under 1 year of age. J Pediatr Urol. 2017 Feb;13(1):47.e1-47.e7. doi: 10.1016/j.jpurol.2016.09.009. Epub 2016 Oct 24.
Publication summary. Over 50 peer reviewed articles in high ranking subspecialty paediatric, surgical or urological journals (20 as first or senior author and 19 in last 5 years. Citations: 650 (6 publications with more than 20 citations), H-index: 15
Research outputs other than publications:
· Parental Perceptions of Medical Communication in Short Gut Syndrome ($10,000) (A Deshpande, S Nightingale, M Heinsch, J Rich)
· Educational Grant to Develop Resources for Health Care Practitioners in Nocturnal Enuresis ($40,000) (A Deshpande)
· Equipment/pilot/seeding grants (two) in 2017, University of Newcastle, PRC GuW ($10,000) (A Deshpande)
· HCRF grant (2017): Mouse model to study ILC-2 in urinary infection ($20,000) (M Starkey, A Deshpande, A Collison)
· HNEkidshealth Innovation Scholarship to Improve Healthcare Communication in Intestinal Failure 2018 (19154$)
· Targeted Donor Research Grant for Better Treatment of Cystinuria, University of Newcastle ($ 100,000)
· Translational Research Grant (co-author only) ($ 493,706) “eADVICE - Advice while you wait: Empowering families, improving health, reducing waiting times’
2) RHD supervision and current research projects
Dr Deshpande is currently a co-supervisor for 3 higher degree by research students ( 1 MPhil, 2 PhD) and has completed supervision of an Honours student (B Biomed Sci) at University of Newcastle. Additionally, he has supervised 5 research projects (2 ongoing) for students and surgical trainees, leading to publication in peer reviewed journals. He also supervised a Quality Improvement project in Healthcare at University of Newcastle.
3) Professional Leadership
Member of the ACI Collaborative Group of Urinary Incontinence in Children. ACI is the NSW Agency for Clinical Innovation and this working group is entrusted with evolving strategies for improved care of children suffering from urinary incontinence.
Reviewer for CareTrack Kids on Urinary Tract Infections in Children. Caretrack Kids is an endeavor by the Children’s Hospitals of Australasia which builds clinical consensus on paediatric problems to inform day to day practice in Australia and New Zealand.
Invited to be an International Advisor/ Reviewer for Enuresis Guidelines for South Africa
4) National and International Standing (invited talks, invited reviews, etc)
Invited reviews/book chapters: Reviewer for Australian Medical Handbook for Children, 2015 edition, Paediatric Trauma Manual (RCH, Melbourne), Handbook of Children’s Hospital at Westmead
Invited speaker: Continence Foundation of Australia, NSW Branch (2017), Hunter Paediatric Update (2015), Kids Bladder Day, Sydney (2015 and 2013), Urological Society of Australia and NZ (2012)
International Invitations: Indian Association of Paediatric Surgeons meeting (2015), Workshop on Bladder Disorders (India, April 2016)
5) Relevant Appointments
Dr Deshpande hold the following research/ review appointments:
Full founding and primary member, Priority Research Centre “GrowupWell”; Contact editor Cochrane collaborator; Member, Surgical Research Society, RACS
6) Peer Review
Cochrane Renal Group; Urology Annals; Journal of Paediatrics and Child Health; ANZ Journal of Surgery; Journal of Urology; BMJ; Archives of Diseases in Childhood; Acta Pediatrica
7) Prizes, Awards, Honours
2015 Best Poster in Minimally Invasive Surgery, IAPSCON, 2015
2007 Young Investigator Award, Children’s Hospital at Westmead, Sydney
1999 Gold Medals in Surgery (Postgraduate) and Pharmacology (Undergraduate)
Teaching and education responsibilities:
Member; Academy of Clinical Education; Joint Medical Program, Faculty of Health and Medicine, University of Newcastle.
Surgical Assessor, Australian Medical Council Workplace Based Assessment Program
Supervisor of Paediatric Surgical Training, Royal Australasian College of Surgeons
Examiner Duties: Honours thesis, Sydney University 2016
Education in Urinary Incontinence in Children: Regular involvement in the education of general practitioners, allied health staff and families of patients, dealing with urinary incontinence in children.
- child health
- paediatric incontinence
- paediatric urology
- rare diseases and consumer perspectives
Fields of Research
|110312||Nephrology and Urology||50|
For publications that are currently unpublished or in-press, details are shown in italics.
Journal article (52 outputs)
Ng R, Eliezer D, Vilain R, Kamien B, Deshpande AV, 'Fatal Exsanguination Following Rupture of an Iliac Artery Aneurysm in an Infant With Menkes Disease', Pediatric and Developmental Pathology, (2019)
© 2019, Society for Pediatric Pathology All rights reserved. Menkes disease (MD) usually presents in infancy with respiratory and neurological complications. Severe isolated vascu... [more]
© 2019, Society for Pediatric Pathology All rights reserved. Menkes disease (MD) usually presents in infancy with respiratory and neurological complications. Severe isolated vasculo-connective tissue involvement in infancy is rare, and hence the precise and timely diagnosis is difficult. We report a case of an 8-week-old male infant who succumbed to acute, severe exsanguination, and hemorrhagic shock secondary to a large retroperitoneal hematoma due to rupture of a right iliac artery aneurysm. Perimortem musculoskeletal findings raised suspicion of nonaccidental injury. However, postmortem review of facial traits raised the suspicion of MD. MD was subsequently confirmed on genetic testing. Child health clinicians must remain aware of MD as a rare cause of infant vasculopathy or atypical skeletal abnormalities.
Cameron GJM, Jiang SH, Loering S, Deshpande AV, Hansbro PM, Starkey MR, 'Emerging therapeutic potential of group 2 innate lymphoid cells in acute kidney injury.', J Pathol, 248 9-15 (2019)
Cameron GJM, Cautivo KM, Loering S, Jiang SH, Deshpande AV, Foster PS, et al., 'Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury', FRONTIERS IN IMMUNOLOGY, 10 (2019)
Woodford E, Eliezer D, Deshpande A, Kumar R, 'Is excision of testicular nubbin necessary in vanishing testis syndrome?', Journal of Pediatric Surgery, 53 2495-2497 (2018) [C1]
© 2018 Background/Purpose: Vanishing Testes Syndrome 1 (VTS) is one of the most common causes of impalpable testes in children. The role of removal of testicular nubbins owing to... [more]
© 2018 Background/Purpose: Vanishing Testes Syndrome 1 (VTS) is one of the most common causes of impalpable testes in children. The role of removal of testicular nubbins owing to malignant potential in VTS is unclear. We sought to evaluate whether testicular nubbins need to be excised owing to this potential. Methods: We conducted a retrospective review of children with a clinical diagnosis of impalpable testes aged 0¿18 who presented to our tertiary hospital between 2007 and 2017. VTS was defined as the presence of hypoplastic vas entering a closed internal inguinal ring or remnants of gonadal tissue distally. Data collected included: age at operation, need for laparoscopy, location of nubbin and histopathological findings. Results: We identified 50 consecutive children (mean age 2.4 years, range: 7 months to 12 years) with a clinical diagnosis of impalpable testis. Forty-eight of the 50 underwent laparoscopy with no testicle palpable when examined under anesthesia. Thirty-three children had VTS confirmed at laparoscopy and testicular nubbins identified with three of these being bilateral. Thirty-two children had these nubbins excised with histopathology available for 31 individual testes. Thirty were confirmed testicular nubbins with no viable testicular tissue. No malignancies were identified. Conclusion: Results from this study show that testicular nubbins do not have viable germ cells and therefore do not need to be excised on the basis of malignant potential of residual testicular tissue. Level of evidence: Level IV treatment study.
Adam A, Claassen F, Coovadia A, de Maayer T, Fockema M, Fredericks J, et al., 'The South African guidelines on Enuresis¿2017', African Journal of Urology, 24 1-13 (2018) [C1]
© 2018 Pan African Urological Surgeons Association Introduction: Enuresis (or Nocturnal Enuresis) is defined as discreet episodes of urinary incontinence during sleep in children ... [more]
© 2018 Pan African Urological Surgeons Association Introduction: Enuresis (or Nocturnal Enuresis) is defined as discreet episodes of urinary incontinence during sleep in children over 5 years of age in the absence of congenital or acquired neurological disorders. Recommendations: Suggestions and recommendations are made on the various therapeutic options available within a South African context. These therapeutic options include; behavioural modification, pharmaceutical therapy [Desmospressin (DDAVP), Anticholinergic (ACh) Agents, Mirabegron (ß3-adrenoreceptor agonists), and Tricyclic Antidepressants (TCA)], alternative treatments, complementary therapies, urotherapy, alarm therapy, psychological therapy and biofeedback. The role of the Bladder Diary, additional investigations and Mobile Phone Applications (Apps) in enuresis is also explored. Standardised definitions are also outlined within this document. Conclusion: An independent, unbiased, national evaluation and treatment guideline based on the pathophysiological subcategory is proposed using an updated, evidence based approach. This Guideline has received endorsement from the South African Urological Association, Enuresis Academy of South Africa and further input from international experts within the field.
Deshpande AV, 'Current strategies to predict and manage sequelae of posterior urethral valves in children', Pediatric Nephrology, 33 1651-1661 (2018) [C1]
Jog S, Prayag S, Rajhans P, Zirpe K, Dixit S, Pillai L, et al., 'Dengue infection with multiorgan dysfunction: SOFA score, arterial lactate and serum albumin levels are predictors of outcome', INTENSIVE CARE MEDICINE, 41 2029-2030 (2015)
Mandaliya PH, Morten M, Kumar R, James A, Deshpande A, Murphy VE, et al., 'Ventilation inhomogeneities in children with congenital thoracic malformations', BMC Pulmonary Medicine, 15 (2015) [C1]
© Morten et al.; licensee BioMed Central. Background: Congenital thoracic malformations (CTM) are rare lung lesions that are managed with surgical resection or active surveillance... [more]
© Morten et al.; licensee BioMed Central. Background: Congenital thoracic malformations (CTM) are rare lung lesions that are managed with surgical resection or active surveillance. Methods: Nitrogen lung clearance index (LCI), reactance and resistance (X5Hz and R5Hz), forced expiratory volume in 1 s and forced vital capacity (FEV1 and FVC) were prospectively measured in 10 children with CTM (mean age/SD: 7.6/1.3) who had undergone surgical resection in early life and in 17 healthy children (mean age/SD: 4.8/0.4). Total lung capacity (TLC) was also conducted in children older than 7 years of age with CTM (n = 8). Results: Mean LCI was 8.0 (95% CI 7.5 to 8.5) in the CTM group and 7.3 (95% CI 7.0 to 7.6) in healthy children (p = 0.016). Mean X5Hz was -0.44kPa/l/s (95% CI -0.58 to -0.31) in the CTM group and -0.31kPa/l/s (95% CI -0.35 to -0.27) in healthy children (p = 0.02). Mean Z score for X5Hz was -2.11 (95% CI -3.59 to -0.63) in the CTM group and -0.11 (95% CI -0.55 to 0.33) in healthy children (p = 0.0008). Mean FEV1 was 1.21 L (95% CI 0.97 to 1.45) in the CTM group and 1.02 L (95% CI 0.90 to 1.15) in healthy children (p = 0.22). Mean % predicted FEV1 was 83% (95% CI 74 to 92) in the CTM group and 97% (95% CI 87 to 107) in healthy children (p < 0.05). Mean % predicted TLC in CTM children was 121.3% (95% CI 88.45 to 154.1). Mean LCI was inversely correlated with height z-scores in the CTM group (rs = -0.88, p = 0.002) but not in healthy children (rs = 0.22, p = 0.4). Conclusions: Children with CTM have impaired lung function as demonstrated by the significant differences in LCI, reactance and FEV1 but not FVC, resistance and TLC. These findings may be of clinical relevance as ventilation inhomogeneities are closely correlated with somatic growth in this study.
Smith GHH, Deshpande AV, Tang RWK, 'Uncommon causes of anterior urethral diverticula in children: Two cases and review of literature', Urology Annals, 6 75-79 (2014)
Anterior urethral diverticula are rare in children. Anterior urethral valves and associated diverticulum is the commonly discussed pathological entity in children. There is a lack... [more]
Anterior urethral diverticula are rare in children. Anterior urethral valves and associated diverticulum is the commonly discussed pathological entity in children. There is a lack of awareness among clinicians regarding less common presentations of anterior urethral diverticula in children; which can have a diverse involvement of the urinary tract. This report describes two uncommon presentations of anterior urethral diverticula in children, their diagnoses and management. A systematic differential diagnosis and review of anterior urethral diverticula in children is also presented.
Deshpande AV, Michail P, Smith GH, 'Interventions for undescended testes in children', Cochrane Database of Systematic Reviews, 2014 (2014)
© 2014 The Cochrane Collaboration. This is the protocol for a review and there is no abstract. The objectives are as follows: This review aims to look at the benefits and harms of... [more]
© 2014 The Cochrane Collaboration. This is the protocol for a review and there is no abstract. The objectives are as follows: This review aims to look at the benefits and harms of interventions for undescended testes in children performed in order to facilitate placement of the testis or testes in a scrotal position without subsequent atrophy.
Alsaywid BS, Deshpande AV, Smith GH, Farnsworth RH, Webb NR, 'Antibiotic prophylaxis for transurethral urological procedures', Cochrane Database of Systematic Reviews, 2014 (2014)
© 2014 The Cochrane Collaboration. This is the protocol for a review and there is no abstract. The objectives are as follows: The aim of this review is to assess the benefits and ... [more]
© 2014 The Cochrane Collaboration. This is the protocol for a review and there is no abstract. The objectives are as follows: The aim of this review is to assess the benefits and harms of antibiotic prophylaxis given during the perioperative period, for reducing the risk of UTIs following transurethral urological procedures in both adults and children.
Deshpande AV, 'Long-Term Followup of Children with Nocturnal Enuresis: Increased Frequency of Nocturia in Adulthood EDITORIAL COMMENT', JOURNAL OF UROLOGY, 191 1870-1871 (2014) [C3]
Thakkar D, Deshpande AV, Kennedy SE, 'Epidemiology and demography of recently diagnosed cases of posterior urethral valves', PEDIATRIC RESEARCH, 76 560-563 (2014)
Caldwell PHY, Deshpande AV, Von Gontard A, 'Management of nocturnal enuresis.', BMJ, 347 f6259 (2013)
Jog S, Patel D, Dravid T, Rajhans P, Akole P, Pawar B, et al., 'Early application of high frequency oscillatory ventilation in 'H1N1 influenza' related ARDS is associated with better outcome: A retrospective study', Intensive Care Medicine, 39 1146-1147 (2013)
Dannaway J, Ng H, Deshpande AV, 'Adherence to ICCS nomenclature guidelines in subsequent literature: A bibliometric study', Neurourology and Urodynamics, 32 952-956 (2013)
Deshpande AV, Craig JC, Smith GHH, Caldwell PHY, 'Management of daytime urinary incontinence and lower urinary tract symptoms in children', Journal of Paediatrics and Child Health, 48 E44-E52 (2012)
Jog S, Patel M, Patel D, 'Early application of high-frequency oscillatory ventilation in H1N1 influenza-related severe ARDS is associated with better outcome', Critical Care, 16 P111-P111 (2012)
Deshpande AV, Alsaywid BS, Smith GHH, 'Setting the Speed Limit: A Pilot Study of the Rate of Serum Creatinine Decrease After Endoscopic Valve Ablation in Neonates', JOURNAL OF UROLOGY, 185 2497-2500 (2011) [C1]
Deshpande AV, Craig JC, Smith GHH, Caldwell PHY, 'Factors Influencing Quality of Life in Children With Urinary Incontinence', JOURNAL OF UROLOGY, 186 1048-1052 (2011) [C1]
Cohen R, Tsang I, Ambler G, Fleming S, Deshpande A, 'The validity of testicular catch-up growth and serum FSH levels in the long-term postoperative assessment of laparoscopic varicocele correction in adolescents', Urology Annals, 3 29-29 (2011)
Deshpande AV, Thomas G, Shun A, Roy GT, Stormon M, Gaskin K, 'Dominant dorsal duct syndrome: A rare cause of acute recurrent pancreatitis in children revisited', Pancreas, 39 97-100 (2010) [C2]
|Show 49 more journal articles|
Conference (4 outputs)
Umesh G, Nayak BMG, Deshpande A, 'Design and analysis of a capacitively-coupled clamped-clamped MEMS resonator', Proceedings - 2014 6th International Conference on Computational Intelligence and Communication Networks, CICN 2014 (2014)
© 2014 IEEE. This document details the design, implementation and analysis of a clamped-clamped capacitively-coupled beam resonator with a high Q-factor [>10000] in the VHF ban... [more]
© 2014 IEEE. This document details the design, implementation and analysis of a clamped-clamped capacitively-coupled beam resonator with a high Q-factor [>10000] in the VHF band [30-300MHz]. The document also draws a parallel between simulation results and theoretical results of key performance metrics of the design.
Mandaliya PH, Morten M, Kumar R, James A, Whitehead B, Platt L, et al., 'Lung Clearance Index (lci) May Be More Sensitive In Detecting Residual Lung Function Abnormalities In Children Operated For Suspected Congenital Cystic Adenomatoid Malformation In Infancy', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)
Al Saywid BS, Deshpande A, Bidarkar S, Cohen RC, Holland AJA, Smith GHH, 'SURGICAL MANAGEMENT OF UNDESCENDED TESTIS: TAKING STOCK', JOURNAL OF UROLOGY (2011)
|Show 1 more conference|
Creative Work (1 outputs)
|2018||Deshpande ANIRUDDH, Nocturnal enuresis Resource kit (neresourcekit.com.au) (2018)|
Other (1 outputs)
|2019||Deshpande A, 'Eliezer D, Deshpande AV, Starkey MR, Samnakay N, Oldmeadow C, Kernohan A. Alpha blockers for treating functional daytime urinary incontinence in children. Cochrane Database of Systematic Reviews 2019, Issue 4. Art. No.: CD013313. DOI: 10.1002/14651858.CD013313.', Eliezer D, Deshpande AV, Starkey MR, Samnakay N, Oldmeadow C, Kernohan A. Alpha blockers for treating functional daytime urinary incontinence in children. Cochrane Database of Systematic Reviews 2019, Issue 4. Art. No.: CD013313. DOI: 10.1002/14651858.CD013313.: John Wiley & Sons Inc. (2019)|
Grants and Funding
|Number of grants||7|
Click on a grant title below to expand the full details for that specific grant.
20191 grants / $25,000
Can we improve the management of bladder dysfunction and chronic recurrent urinary tract infections in children through manipulation of the fecal and urinary microbiota: a pilot study$25,000
Funding body: Hunter Medical Research Institute
20183 grants / $569,860
“eADVICE - Advice while you wait: Empowering families, improving health, reducing waiting times’$493,706
Funding body: NSW Health
|Funding body||NSW Health|
|Scheme||Translational Research Grants Scheme|
|Type Of Funding||Aust Competitive - Commonwealth|
Funding body: Hunter Medical Research Institute
|Funding body||Hunter Medical Research Institute|
|Project Team||Doctor Malcolm Starkey, Doctor Aniruddh Deshpande, Professor Phil Hansbro, Dr Simon Jiang|
|Type Of Funding||C3120 - Aust Philanthropy|
HNEkidshealth Innovation Scholarship to Improve Healthcare Communication in Intestinal Failure 2018$19,154
Funding body: Hunter New England Area Health Service
|Funding body||Hunter New England Area Health Service|
|Type Of Funding||Other Public Sector - Local|
20173 grants / $70,000
Funding body: Ferring Pharmaceuticals
|Funding body||Ferring Pharmaceuticals|
Dr Aniruddh Deshpande, A/prof PHY Caldwell
|Type Of Funding||External|
Funding body: Hunter Medical Resarch Institute (HMRI) Public Health Program
|Funding body||Hunter Medical Resarch Institute (HMRI) Public Health Program|
|Type Of Funding||Other Public Sector - Local|
Countess II FL$10,000
Funding body: NSW Ministry of Health
|Funding body||NSW Ministry of Health|
|Project Team||Doctor Malcolm Starkey, Doctor Adam Collison, Doctor Hock Tay, Doctor Aniruddh Deshpande, Doctor Gang Liu, Doctor Jemma Mayall|
|Scheme||Medical Research Support Program (MRSP)|
|Type Of Funding||C2220 - Aust StateTerritoryLocal - Other|
Number of supervisions
|Commenced||Level of Study||Research Title||Program||Supervisor Type|
|2018||PhD||Mechanisms Underlying Immune Cell-Mediated Repair of the Kidney Following Injury||PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle||Co-Supervisor|
|2018||Masters||Clinical Implications of Congenital and Developmental Conditions of the Paediatric Genitourinary Tract||M Philosophy(Surgical Science), Faculty of Health and Medicine, The University of Newcastle||Co-Supervisor|
|2018||PhD||Understanding the Role of Group 2 Innate Lymphoid Cells in the Pathogenesis of Cystinuria and Kidney Stones||PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle||Co-Supervisor|
Dr Aniruddh Deshpande
Conjoint Senior Lecturer
School of Medicine and Public Health
Faculty of Health and Medicine