Dr Ajay Karakoti

Associate Professor

School of Engineering

Career Summary

Biography

Dr. Ajay Karakoti is a broad based materials researcher focused on the synthesis of novel bare and functionalized nanoparticles for applications in biology, catalysis and sensing. His research is focused on both the applications and detailed surface and bulk characterization of these materials. A significant portion of his research deals with developing a detailed understanding of the reaction of cerium oxide nanoparticles with reactive oxygen species and the consequence of size, structure, doping and surface functional groups on its enzyme like activity. Prior to joining GICAN he was an Associate Professor at the Ahmedabad University where taught at both the engineering and the life sciences department. He also received funding for development of a series of redox tunable cerium oxide nanoparticles for applications as natural enzymes, development of research infrastructure and a technology incubator. He has also worked in the industry at the Battelle Science and Technology India Pvt. Ltd. where he gained experience of fast paced industrial research and product development. He has worked on multiple projects based on nanomaterials and has a broad background in applications such as nanozymes, gas sensors, sol-gel antireflective coatings, corrosion protection, drug delivery, fly ash based self-cementing materials and surface functionalization of beverage filters. He has published more than 65 research articles that have been cited more than 7000 times and have an H-index of 36 (Source Google Scholar). He has been granted 3 US patents and has applied for 2 full and 1 provisional patent in India. He is also an entrepreneur and have experience in setting up and running start-up companies in India. He was the recipient of M.T. Thomas Award for outstanding post-doctoral research at the Environmental and Molecular Sciences Laboratory, PNNL, USA in 2012 and was recently (2018) awarded the NASI-Scopus Young Scientist Award in India for the category - Innovations in Engineering and Physical Sciences.


Qualifications

  • Doctor of Philosophy, University of Florida - USA

Keywords

  • Biosensors
  • Nano-biomaterials
  • Nanotechnology
  • Nanozymes
  • Surface Science
  • cerium oxide nanoparticles

Fields of Research

Code Description Percentage
100703 Nanobiotechnology 40
100712 Nanoscale Characterisation 30
030603 Colloid and Surface Chemistry 30

Professional Experience

UON Appointment

Title Organisation / Department
Associate Professor University of Newcastle
School of Engineering
Australia

Academic appointment

Dates Title Organisation / Department
7/1/2015 - 31/12/2018 Associate Professor Ahmedabad University
India
28/6/2010 - 7/9/2012 Postdoctorate Research Associate Pacific Northwest National Laboratory
United States

Professional appointment

Dates Title Organisation / Department
10/9/2012 - 31/10/2014 Principal Scientist Battelle Science and Technology India Pvt Ltd
India
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (3 outputs)

Year Citation Altmetrics Link
2019 Baer DR, Cant DJH, Castner DG, Ceccone G, Engelhard MH, Karakoti AS, Müller A, 'Preparation of nanoparticles for surface analysis', Characterization of Nanoparticles: Measurement Processes for Nanoparticles 295-347 (2019)

© 2020 Elsevier Inc. All rights reserved.. A variety of methods used to prepare nano-objects for surface analysis are described along with information about when they might be bes... [more]

© 2020 Elsevier Inc. All rights reserved.. A variety of methods used to prepare nano-objects for surface analysis are described along with information about when they might be best applied. Intrinsic properties of NPs that complicate their characterization and need to be considered when planning for surface or other analyses of NPs are identified, including challenges associated with reproducible synthesis and functionalization of the particles as well as their dynamic nature. The relevant information about the sample preparation processes along with analysis details and data that need to be added to the collection of material provenance information is identified. Examples of protocols that have been successfully used for preparation of nano-objects for surface analysis are included in an annex.

DOI 10.1016/B978-0-12-814182-3.00018-3
Citations Scopus - 4
2019 Panchal D, Patel R, Siddheshwari M, Rahaman E, Patel V, Karakoti AS, 'CHAPTER 4: NP-Protein Corona Interaction: Characterization Methods and Analysis', Issues in Toxicology 80-131 (2019)

© The Royal Society of Chemistry 2019. The protein corona, as suggested throughout this book, is the term used for layers of proteins on the surfaces of materials directly in cont... [more]

© The Royal Society of Chemistry 2019. The protein corona, as suggested throughout this book, is the term used for layers of proteins on the surfaces of materials directly in contact with a milieu of proteins. These layers are formed from the specific as well as non-specific adsorption of proteins on the surfaces of materials and thus can be regarded as an upgraded name for protein adsorption. Adsorption of proteins on surfaces gained importance in the early 60 s and the field drew the attention of various researchers who characterized the adsorption of proteins on multiple surfaces. The field started to gain much more interest in the early 80 s and 90 s as the transformation from ultrafine to nanoparticle-based chemistry surfaced. Liposomes and polymeric nanoparticle interactions with protein surfaces got specific attention as strategies around drug delivery started to emerge to create adsorption-resistant nanoparticle surfaces. While the concepts emerge gradually over time, the main theme of protein corona formation remains unchanged. In this chapter, we will briefly introduce nanoparticles and the nanoparticle protein corona. Aspects of the protein corona will be discussed so that the user can correlate the basic properties of corona formation that are studied using various characterization techniques. This will be followed by a brief introduction to the sampling methods and principles of various analytical techniques excluding the optical and electron-microscopy-based imaging techniques. The reader is encouraged to refer to books and journals for details of each analytical technique as a full description is beyond the scope of this chapter. Finally, relevant characteristics and properties of the nanoparticle-protein corona interaction are discussed based on the characterization technique that will help the reader to understand the utility of such characterization techniques in practice.

DOI 10.1039/9781788016308-00080
2011 Seal S, Self W, McGinnis J, Karakoti AS, 'Nanoparticles for novel healthcare therapeutics', New Materials and Technologies for Healthcare 49-55 (2011)
DOI 10.1142/9781848165595_0004

Journal article (78 outputs)

Year Citation Altmetrics Link
2021 Singh G, Bahadur R, Mee Lee J, Young Kim I, Ruban AM, Davidraj JM, et al., 'Nanoporous activated biocarbons with high surface areas from alligator weed and their excellent performance for CO
DOI 10.1016/j.cej.2020.126787
Co-authors Gurwinder Singh, Ajayan Vinu, Jangmee Lee
2020 Baldim V, Yadav N, Bia N, Graillot A, Loubat C, Singh S, et al., 'Polymer-Coated Cerium Oxide Nanoparticles as Oxidoreductase-like Catalysts', ACS applied materials & interfaces, 12 42056-42066 (2020) [C1]

Cerium oxide nanoparticles have been shown to mimic oxidoreductase enzymes by catalyzing the decomposition of organic substrates and reactive oxygen species. This mimicry can be f... [more]

Cerium oxide nanoparticles have been shown to mimic oxidoreductase enzymes by catalyzing the decomposition of organic substrates and reactive oxygen species. This mimicry can be found in superoxide radicals and hydrogen peroxides, which are harmful molecules produced in oxidative stress-associated diseases. Despite the fact that nanoparticle functionalization is mandatory in the context of nanomedicine, the influence of polymer coatings on their enzyme-like catalytic activity is poorly understood. In this work, six polymer-coated cerium oxide nanoparticles are prepared by the association of 7.8 nm cerium oxide cores with two poly(sodium acrylate) and four poly(ethylene glycol) (PEG)-grafted copolymers with different terminal or anchoring end groups, such as phosphonic acids. The superoxide dismutase-, catalase-, peroxidase-, and oxidase-like catalytic activities of the coated nanoparticles were systematically studied. It is shown that the polymer coatings do not affect the superoxide dismutase-like, impair the catalase-like and oxidase-like, and surprisingly improves peroxidase-like catalytic activities of cerium oxide nanoparticles. It is also demonstrated that the particles coated with the PEG-grafted copolymers perform better than the poly(acrylic acid)-coated ones as oxidoreductase-like enzymes, a result that confirms the benefit of having phosphonic acids as anchoring groups at the particle surface.

DOI 10.1021/acsami.0c08778
2020 Ramadass K, Sathish CI, MariaRuban S, Kothandam G, Joseph S, Singh G, et al., 'Carbon Nanoflakes and Nanotubes from Halloysite Nanoclays and their Superior Performance in CO2 Capture and Energy Storage.', ACS Appl Mater Interfaces, 12 11922-11933 (2020) [C1]
DOI 10.1021/acsami.9b21510
Co-authors Stalin Joseph, Kavitha Ramadass, Sathish Ci, Jiabao Yi, Gurwinder Singh, Ajayan Vinu
2020 Vallabani NVS, Vinu A, Singh S, Karakoti A, 'Tuning the ATP-triggered pro-oxidant activity of iron oxide-based nanozyme towards an efficient antibacterial strategy', Journal of Colloid and Interface Science, 567 154-164 (2020) [C1]
DOI 10.1016/j.jcis.2020.01.099
Citations Scopus - 3Web of Science - 1
Co-authors Ajayan Vinu
2020 Karakoti A, Yi J, Vinu A, 'Emerging Advanced Nanomaterials and their Applications', SMALL, 16 (2020)
DOI 10.1002/smll.202001287
Co-authors Jiabao Yi, Ajayan Vinu
2020 Kansara K, Kumar A, Karakoti AS, 'Combination of humic acid and clay reduce the ecotoxic effect of TiO2 NPs: A combined physico-chemical and genetic study using zebrafish embryo', SCIENCE OF THE TOTAL ENVIRONMENT, 698 (2020)
DOI 10.1016/j.scitotenv.2019.134133
Citations Scopus - 2Web of Science - 2
2020 Yang JH, Kim S, Kim IY, Lee JM, Yi J, Karakoti A, et al., 'Highly enhanced photocatalytic hydrogen evolution activity of graphitic carbon nitride with 3D connected mesoporous structure', Sustainable Materials and Technologies, 25 (2020) [C1]

© 2020 Elsevier B.V. In this report, we demonstrate on the preparation of mesoporous graphitic carbon nitride (gCN) with 3D porous structure using dicyandiamide as a CN precursor ... [more]

© 2020 Elsevier B.V. In this report, we demonstrate on the preparation of mesoporous graphitic carbon nitride (gCN) with 3D porous structure using dicyandiamide as a CN precursor and KIT-6 as a template via hard-template replication method and its superior photocatalytic hydrogen evolution activity under simulated sunlight. The powder X-ray diffraction, nitrogen adsorption and near edge X-ray absorption fine structure (NEXAFS) results reveal that the prepared materials possess gCN crystal structure with ordered mesopores and a 3D porous structure and a high specific surface area (221 m2/g). UV¿Vis and PL spectra show that the absorption edges of mesoporous gCNs are slightly blue-shifted and the PL intensity is remarkably suppressed. The photocatalytic hydrogen evolution activity of gCN-KIT-6 under solar simulated irradiation is 1.92 mmol·g-1 h-1 which is much higher than that of gCN with 2D mesoporous structure, gCN from silica nanoparticle and bulk nonporous gCN. This high photocatalytic activity of gCN-KIT-6 can be attributed to 3D structure and the retarded electron-hole recombination.

DOI 10.1016/j.susmat.2020.e00184
Co-authors Ajayan Vinu, Jaehun Yang, Jangmee Lee, Jiabao Yi, Stalin Joseph
2020 Talapaneni SN, Singh G, Kim IY, AlBahily K, Al-Muhtaseb AH, Karakoti AS, et al., 'Nanostructured Carbon Nitrides for CO2 Capture and Conversion', Advanced Materials, 32 (2020) [C1]
DOI 10.1002/adma.201904635
Citations Scopus - 19Web of Science - 22
Co-authors Ajayan Vinu, Gurwinder Singh, Siddulunaidu Talapaneni
2020 Singh G, Lee J, Karakoti A, Bahadur R, Yi J, Zhao D, et al., 'Emerging trends in porous materials for CO2 capture and conversion.', Chemical Society Reviews, 49 4360-4404 (2020) [C1]
DOI 10.1039/d0cs00075b
Citations Scopus - 6Web of Science - 2
Co-authors Jiabao Yi, Gurwinder Singh, Ajayan Vinu, Jangmee Lee
2019 Vallabani NVS, Singh S, Karakoti AS, 'Investigating the role of ATP towards amplified peroxidase activity of Iron oxide nanoparticles in different biologically relevant buffers', APPLIED SURFACE SCIENCE, 492 337-348 (2019)
DOI 10.1016/j.apsusc.2019.06.177
Citations Scopus - 3Web of Science - 4
2019 Kansara K, Paruthi A, Misra SK, Karakoti AS, Kumar A, 'Montmorillonite clay and humic acid modulate the behavior of copper oxide nanoparticles in aqueous environment and induces developmental defects in zebrafish embryo', Environmental Pollution, 255 (2019) [C1]
DOI 10.1016/j.envpol.2019.113313
Citations Scopus - 4Web of Science - 3
2019 Kuchibhatla SVNT, Karakoti AS, Vasdekis AE, Windisch CF, Seal S, Thevuthasan S, Baer DR, 'An unexpected phase transformation of ceria nanoparticles in aqueous media', JOURNAL OF MATERIALS RESEARCH, 34 465-473 (2019)
DOI 10.1557/jmr.2018.490
2019 Vallabani NVS, Singh S, Karakoti AS, 'Magnetic Nanoparticles: Current Trends and Future Aspects in Diagnostics and Nanomedicine', CURRENT DRUG METABOLISM, 20 457-472 (2019)
DOI 10.2174/1389200220666181122124458
Citations Scopus - 14Web of Science - 16
2018 Bhagat S, Vallabani NVS, Shutthanandan V, Bowden M, Karakoti AS, Singh S, 'Gold core/ceria shell-based redox active nanozyme mimicking the biological multienzyme complex phenomenon', JOURNAL OF COLLOID AND INTERFACE SCIENCE, 513 831-842 (2018)
DOI 10.1016/j.jcis.2017.11.064
Citations Scopus - 38Web of Science - 38
2018 Baer DR, Karakoti AS, Clifford CA, Minelli C, Unger WES, 'Importance of sample preparation on reliable surface characterisation of nano-objects: ISO standard 20579-4', SURFACE AND INTERFACE ANALYSIS, 50 902-906 (2018)
DOI 10.1002/sia.6490
Citations Scopus - 9Web of Science - 7
2018 Patel V, Singh M, Mayes ELH, Martinez A, Shutthanandan V, Bansal V, et al., 'Ligand-mediated reversal of the oxidation state dependent ROS scavenging and enzyme mimicking activity of ceria nanoparticles', CHEMICAL COMMUNICATIONS, 54 13973-13976 (2018)
DOI 10.1039/c8cc08355j
Citations Scopus - 9Web of Science - 9
2018 Karakoti AS, Yang P, Wang W, Patel V, Martinez A, Shutthanandan V, et al., 'Investigation of the Ligand Nanoparticle Interface: A Cryogenic Approach for Preserving Surface Chemistry', JOURNAL OF PHYSICAL CHEMISTRY C, 122 3582-3590 (2018)
DOI 10.1021/acs.jpcc.7b09930
Citations Scopus - 5Web of Science - 6
2017 Sargia B, Shah J, Singh R, Arya H, Shah M, Karakoti AS, Singh S, 'Phosphate-dependent modulation of antibacterial strategy: a redox state-controlled toxicity of cerium oxide nanoparticles', BULLETIN OF MATERIALS SCIENCE, 40 1231-1240 (2017)
DOI 10.1007/s12034-017-1480-3
Citations Scopus - 3Web of Science - 2
2017 Vallabani NVS, Karakoti AS, Singh S, 'ATP-mediated intrinsic peroxidase-like activity of Fe3O4-based nanozyme: One step detection of blood glucose at physiological pH', COLLOIDS AND SURFACES B-BIOINTERFACES, 153 52-60 (2017)
DOI 10.1016/j.colsurfb.2017.02.004
Citations Scopus - 59Web of Science - 58
2016 Singh R, Karakoti AS, Self W, Seal S, Singh S, 'Redox-Sensitive Cerium Oxide Nanoparticles Protect Human Keratinocytes from Oxidative Stress Induced by Glutathione Depletion', LANGMUIR, 32 12202-12211 (2016)
DOI 10.1021/acs.langmuir.6b03022
Citations Scopus - 43Web of Science - 43
2016 Sanghavi S, Wang W, Nandasiri MI, Karakoti AS, Wang W, Yang P, Thevuthasan S, 'Investigation of trimethylacetic acid adsorption on stoichiometric and oxygen-deficient CeO2(111) surfaces', PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 18 15625-15631 (2016)
DOI 10.1039/c6cp00855k
Citations Scopus - 3Web of Science - 4
2015 Karakoti AS, Shukla R, Shanker R, Singh S, 'Surface functionalization of quantum dots for biological applications', ADVANCES IN COLLOID AND INTERFACE SCIENCE, 215 28-45 (2015)
DOI 10.1016/j.cis.2014.11.004
Citations Scopus - 115Web of Science - 108
2015 Shah J, Purohit R, Singh R, Karakoti AS, Singh S, 'ATP-enhanced peroxidase-like activity of gold nanoparticles', JOURNAL OF COLLOID AND INTERFACE SCIENCE, 456 100-107 (2015)
DOI 10.1016/j.jcis.2015.06.015
Citations Scopus - 53Web of Science - 54
2015 Inerbaev TM, Karakoti AS, Kuchibhatla SVNT, Kumar A, Masunov AE, Seal S, 'Aqueous medium induced optical transitions in cerium oxide nanoparticles', PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 17 6217-6221 (2015)
DOI 10.1039/c4cp04961f
Citations Scopus - 10Web of Science - 9
2015 Pandya A, Tripathi A, Purohit R, Singh S, Nandasiri MI, Karakoti A, et al., 'Fluorescent magnesium nanocomplex in a protein scaffold for cell nuclei imaging applications', RSC ADVANCES, 5 94236-94240 (2015)
DOI 10.1039/c5ra18450a
Citations Scopus - 3Web of Science - 3
2014 Dowding JM, Song W, Bossy K, Karakoti A, Kumar A, Kim A, et al., 'Cerium oxide nanoparticles protect against A beta-induced mitochondrial fragmentation and neuronal cell death', CELL DEATH AND DIFFERENTIATION, 21 1622-1632 (2014)
DOI 10.1038/cdd.2014.72
Citations Scopus - 85Web of Science - 75
2013 Baer DR, Engelhard MH, Johnson GE, Laskin J, Lai J, Mueller K, et al., 'Surface characterization of nanomaterials and nanoparticles: Important needs and challenging opportunities', JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A, 31 (2013)
DOI 10.1116/1.4818423
Citations Scopus - 123Web of Science - 118
2013 Hirst SM, Karakoti A, Singh S, Self W, Tyler R, Seal S, Reilly CM, 'Bio-distribution and in vivo antioxidant effects of cerium oxide nanoparticles in mice', ENVIRONMENTAL TOXICOLOGY, 28 107-118 (2013)
DOI 10.1002/tox.20704
Citations Scopus - 174Web of Science - 154
2013 Giri S, Karakoti A, Graham RP, Maguire JL, Reilly CM, Seal S, et al., 'Nanoceria: A Rare-Earth Nanoparticle as a Novel Anti-Angiogenic Therapeutic Agent in Ovarian Cancer', PLOS ONE, 8 (2013)
DOI 10.1371/journal.pone.0054578
Citations Scopus - 137Web of Science - 122
2013 Lu Z, Karakoti A, Velarde L, Wang W, Yang P, Thevuthasan S, Wang H-F, 'Dissociative Binding of Carboxylic Acid Ligand on Nanoceria Surface in Aqueous Solution: A Joint In Situ Spectroscopic Characterization and First-Principles Study', JOURNAL OF PHYSICAL CHEMISTRY C, 117 24329-24338 (2013)
DOI 10.1021/jp4068747
Citations Scopus - 44Web of Science - 42
2013 Gaynor JD, Karakoti AS, Inerbaev T, Sanghavi S, Nachimuthu P, Shutthanandan V, et al., 'Enzyme-free detection of hydrogen peroxide from cerium oxide nanoparticles immobilized on poly(4-vinylpyridine) self-assembled monolayers', JOURNAL OF MATERIALS CHEMISTRY B, 1 3443-3450 (2013)
DOI 10.1039/c3tb20204f
Citations Scopus - 17Web of Science - 16
2012 Karakoti AS, Munusamy P, Hostetler K, Kodali V, Kuchibhatla S, Orr G, et al., 'Preparation and characterization challenges to understanding environmental and biological impacts of ceria nanoparticles', SURFACE AND INTERFACE ANALYSIS, 44 882-889 (2012)
DOI 10.1002/sia.5006
Citations Scopus - 79Web of Science - 83
2012 Shah V, Shah S, Shah H, Rispoli FJ, McDonnell KT, Workeneh S, et al., 'Antibacterial Activity of Polymer Coated Cerium Oxide Nanoparticles', PLOS ONE, 7 (2012)
DOI 10.1371/journal.pone.0047827
Citations Scopus - 58Web of Science - 49
2012 Kumar A, Devanathan R, Shutthanandan V, Kuchibhata SVNT, Karakoti AS, Yong Y, et al., 'Radiation-Induced Reduction of Ceria in Single and Polycrystalline Thin Films', JOURNAL OF PHYSICAL CHEMISTRY C, 116 361-366 (2012)
DOI 10.1021/jp209345w
Citations Scopus - 21Web of Science - 22
2012 Kuchibhata SVNT, Karakoti AS, Baer DR, Samudrala S, Engelhard MH, Amonette JE, et al., 'Influence of Aging and Environment on Nanoparticle Chemistry: Implication to Confinement Effects in Nanoceria', JOURNAL OF PHYSICAL CHEMISTRY C, 116 14108-14114 (2012)
DOI 10.1021/jp300725s
Citations Scopus - 57Web of Science - 45
2012 Turkowski V, Babu S, Le D, Kumar A, Haldar MK, Wagh AV, et al., 'Linker-Induced Anomalous Emission of Organic-Molecule Conjugated Metal-Oxide Nanoparticles', ACS NANO, 6 4854-4863 (2012)
DOI 10.1021/nn301316j
Citations Scopus - 7Web of Science - 7
2011 Anderson JM, Patel J, Karakoti AS, Greeneltch N, Diaz DJ, Seal S, 'Aging effects of nanoscale ceria in ceria-platinum composite electrodes for direct alcohol electro-oxidation', ELECTROCHIMICA ACTA, 56 2541-2545 (2011)
DOI 10.1016/j.electacta.2010.11.061
Citations Scopus - 10Web of Science - 10
2011 Alili L, Sack M, Karakoti AS, Teuber S, Puschmann K, Hirst SM, et al., 'Combined cytotoxic and anti-invasive properties of redox-active nanoparticles in tumor-stroma interactions', BIOMATERIALS, 32 2918-2929 (2011)
DOI 10.1016/j.biomaterials.2010.12.056
Citations Scopus - 133Web of Science - 129
2011 Singh S, Dosani T, Karakoti AS, Kumar A, Seal S, Self WT, 'A phosphate-dependent shift in redox state of cerium oxide nanoparticles and its effects on catalytic properties', BIOMATERIALS, 32 6745-6753 (2011)
DOI 10.1016/j.biomaterials.2011.05.073
Citations Scopus - 164Web of Science - 160
2011 Kong L, Cai X, Zhou X, Wong LL, Karakoti AS, Seal S, McGinnis JF, 'Nanoceria extend photoreceptor cell lifespan in tubby mice by modulation of apoptosis/survival signaling pathways', NEUROBIOLOGY OF DISEASE, 42 514-523 (2011)
DOI 10.1016/j.nbd.2011.03.004
Citations Scopus - 108Web of Science - 105
2011 Karakoti AS, Das S, Thevuthasan S, Seal S, 'PEGylated Inorganic Nanoparticles', ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50 1980-1994 (2011)
DOI 10.1002/anie.201002969
Citations Scopus - 360Web of Science - 350
2011 Zhou X, Wong LL, Karakoti AS, Seal S, McGinnis JF, 'Nanoceria Inhibit the Development and Promote the Regression of Pathologic Retinal Neovascularization in the Vldlr Knockout Mouse', PLOS ONE, 6 (2011)
DOI 10.1371/journal.pone.0016733
Citations Scopus - 105Web of Science - 94
2011 Baer DR, Karakoti AS, Munusamy P, Thrall BD, Pounds JG, Teeguarden JG, et al., 'Testing in EHS: What is the current status of experimentation?', Proceedings of the IEEE Conference on Nanotechnology, 18-19 (2011)

This paper explores some of the fundamental and practical issues related to the behavior of nanoparticles in the environment and their potential impacts on human health. In our re... [more]

This paper explores some of the fundamental and practical issues related to the behavior of nanoparticles in the environment and their potential impacts on human health. In our research we have explored the reactive behaviors of nanoparticles with contaminants in the environment, how nanoparticle change in response to their environment and time, and how nanoparticles interact with biological systems of various types. It has become apparent that researchers often underestimate the difficulties of preparing and delivering well characterized nanoparticles for specific types of testing or applications. Difficulties arise in areas that range from not understanding what imparts the nano character of a particle to not knowing the impacts of minor species on the properties of high surface area materials. Some of our adventures and misadventures serve as examples of some of these issues as they relate to providing well defined particles for biological studies. © 2011 IEEE.

DOI 10.1109/NANO.2011.6144671
2011 Karakoti AS, Sanghavi S, Nachimuthu P, Yang P, Thevuthasan S, 'Probing the Size- and Environment-Induced Phase Transformation in CdSe Quantum Dots', JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2 2925-2929 (2011)
DOI 10.1021/jz201243t
Citations Scopus - 20Web of Science - 20
2011 Shirato N, Strader J, Kumar A, Vincent A, Zhang P, Karakoti A, et al., 'Thickness dependent self limiting 1-D tin oxide nanowire arrays by nanosecond pulsed laser irradiation', NANOSCALE, 3 1090-1101 (2011)
DOI 10.1039/c0nr00689k
Citations Scopus - 11Web of Science - 12
2011 Sayle TXT, Inkson BJ, Karakoti A, Kumar A, Molinari M, Moebus G, et al., 'Mechanical properties of ceria nanorods and nanochains; the effect of dislocations, grain-boundaries and oriented attachment', NANOSCALE, 3 1823-1837 (2011)
DOI 10.1039/c0nr00980f
Citations Scopus - 31Web of Science - 31
2010 Singh V, Karakoti A, Kumar A, Saha A, Basu S, Seal S, 'Precursor Dependent Microstructure Evolution and Nonstoichiometry in Nanostructured Cerium Oxide Coatings Using the Solution Precursor Plasma Spray Technique', JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 93 3700-3708 (2010)
DOI 10.1111/j.1551-2916.2010.03985.x
Citations Scopus - 16Web of Science - 13
2010 Karakoti A, Singh S, Dowding JM, Seal S, Self WT, 'Redox-active radical scavenging nanomaterials', CHEMICAL SOCIETY REVIEWS, 39 4422-4432 (2010)
DOI 10.1039/b919677n
Citations Scopus - 315Web of Science - 304
2010 Sharma RK, Karakoti A, Seal S, Zhai L, 'Multiwall carbon nanotube-poly(4-styrenesulfonic acid) supported polypyrrole/manganese oxide nano-composites for high performance electrochemical electrodes', JOURNAL OF POWER SOURCES, 195 1256-1262 (2010)
DOI 10.1016/j.jpowsour.2009.08.093
Citations Scopus - 80Web of Science - 76
2010 Vincent A, Inerbaev TM, Babu S, Karakoti AS, Self WT, Masunov AE, Seal S, 'Tuning Hydrated Nanoceria Surfaces: Experimental/Theoretical Investigations of Ion Exchange and Implications in Organic and Inorganic Interactions', LANGMUIR, 26 7188-7198 (2010)
DOI 10.1021/la904285g
Citations Scopus - 29Web of Science - 27
2010 Karakoti AS, King JES, Vincent A, Seal S, 'Synthesis dependent core level binding energy shift in the oxidation state of platinum coated on ceria-titania and its effect on catalytic decomposition of methanol', APPLIED CATALYSIS A-GENERAL, 388 262-271 (2010)
DOI 10.1016/j.apcata.2010.08.060
Citations Scopus - 21Web of Science - 23
2010 Karakoti AS, Tsigkou O, Yue S, Lee PD, Stevens MM, Jones JR, Seal S, 'Rare earth oxides as nanoadditives in 3-D nanocomposite scaffolds for bone regeneration', JOURNAL OF MATERIALS CHEMISTRY, 20 8912-8919 (2010)
DOI 10.1039/c0jm01072c
Citations Scopus - 80Web of Science - 77
2010 Pirmohamed T, Dowding JM, Singh S, Wasserman B, Heckert E, Karakoti AS, et al., 'Nanoceria exhibit redox state-dependent catalase mimetic activity', CHEMICAL COMMUNICATIONS, 46 2736-2738 (2010)
DOI 10.1039/b922024k
Citations Scopus - 567Web of Science - 539
2010 Singh V, Babu S, Karakoti AS, Agarwal A, Seal S, 'Effect of Submicron Grains on Ionic Conductivity of Nanocrystalline Doped Ceria', JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 10 6495-6503 (2010)
DOI 10.1166/jnn.2010.2523
Citations Scopus - 24Web of Science - 29
2010 Singh S, Kumar A, Karakoti A, Seal S, Self WT, 'Unveiling the mechanism of uptake and sub-cellular distribution of cerium oxide nanoparticles', MOLECULAR BIOSYSTEMS, 6 1813-1820 (2010)
DOI 10.1039/c0mb00014k
Citations Scopus - 110Web of Science - 103
2010 Anderson J, Karakoti A, Diaz DJ, Seal S, 'Nanoceria-Modified Platinum-Gold Composite Electrodes for the Electrochemical Oxidation of Methanol and Ethanol in Acidic Media', JOURNAL OF PHYSICAL CHEMISTRY C, 114 4595-4602 (2010)
DOI 10.1021/jp911099r
Citations Scopus - 21Web of Science - 20
2010 Zou J, Liu J, Karakoti AS, Kumar A, Joung D, Li Q, et al., 'Ultralight Multiwalled Carbon Nanotube Aerogel', ACS NANO, 4 7293-7302 (2010)
DOI 10.1021/nn102246a
Citations Scopus - 356Web of Science - 350
2009 Karakoti AS, Singh S, Kumar A, Malinska M, Kuchibhatla SVNT, Wozniak K, et al., 'PEGylated Nanoceria as Radical Scavenger with Tunable Redox Chemistry', JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131 14144-14145 (2009)
DOI 10.1021/ja9051087
Citations Scopus - 218Web of Science - 216
2009 Kumar A, Babu S, Karakoti AS, Schulte A, Seal S, 'Luminescence Properties of Europium-Doped Cerium Oxide Nanoparticles: Role of Vacancy and Oxidation States', LANGMUIR, 25 10998-11007 (2009)
DOI 10.1021/la901298q
Citations Scopus - 193Web of Science - 184
2009 Kuchibhatla SVNT, Karakoti AS, Sayle DC, Heinrich H, Seal S, 'Symmetry-Driven Spontaneous Self-Assembly of Nanoscale Ceria Building Blocks to Fractal Superoctahedra', CRYSTAL GROWTH & DESIGN, 9 1614-1620 (2009)
DOI 10.1021/cg801358z
Citations Scopus - 16Web of Science - 17
2009 Hirst SM, Karakoti AS, Tyler RD, Sriranganathan N, Seal S, Reilly CM, 'Anti-inflammatory Properties of Cerium Oxide Nanoparticles', SMALL, 5 2848-2856 (2009)
DOI 10.1002/smll.200901048
Citations Scopus - 416Web of Science - 396
2009 Schanen BC, Karakoti AS, Seal S, Drake DR, Warren WL, Self WT, 'Exposure to Titanium Dioxide Nanomaterials Provokes Inflammation of an in Vitro Human Immune Construct', ACS NANO, 3 2523-2532 (2009)
DOI 10.1021/nn900403h
Citations Scopus - 119Web of Science - 108
2009 Bhargava N, Das M, Karakoti AS, Patil S, Kang JF, Stancescu M, et al., 'Regeneration of adult mice motoneurons utilizing a defined system and anti-oxidant nanoparticles', Journal of Nanoneuroscience, 1 130-143 (2009)

We have developed a novel culture model to grow adult mice spinal cord cells. The model consisted of a serum-free medium supplemented with different growth factors, nanoparticles ... [more]

We have developed a novel culture model to grow adult mice spinal cord cells. The model consisted of a serum-free medium supplemented with different growth factors, nanoparticles and a silane substrate. The following growth factors and nanoparticles constitute the novel serum-free medium: Acidic FGF, Heparan-Sulphate, GDNF, BDNF, CNTF, CT-1, NT-3, NT-4, VEGF, LIF, Vitronectin, B27 supplement, G5 supplement and Cerium oxide nanoparticles. Synergistic effects of these growth factors, nanoparticles and silane substrate promote survival and growth of spinal-cord neurons and glial cells. Based on the cell body size, number of processes and process lengths the cells were categorized into three different groups: Groups I, II and III. Apart from these three cell groups, some of the cells grew in clumps. We categorized the clumps as Group IV. Cells were immunocytochemically characterized by antibodies against NF-150 and GFAP. The cells in Group I, which were found in a small percentage (~10%) in each culture, were then further characterized. These cells had large, multi-polar, cell bodies (30-35 µm) and long processes (~500-800 µm) and they also stained positive for all three motoneuron specific antibodies; ChAT, Islet-1 and MO-1. Based on morphological and immunocytochemical analysis it was concluded that this small percentage of large, multi-polar cells were regenerating motoneurons. Preliminary electrophysiological studies indicated that the cells with this neuronal morphology fired single action potentials. This novel model system could be used as a tool to study spinal injuries and neurodegenerative diseases of aging spinal cord. Copyright © 2009 American Scientific Publishers. All rights reserved.

DOI 10.1166/jns.2009.1002
Citations Scopus - 9
2008 Baer DR, Amonette JE, Engelhard MH, Gaspar DJ, Karakoti AS, Kuchibhatla S, et al., 'Characterization challenges for nanomaterials', SURFACE AND INTERFACE ANALYSIS, 40 529-537 (2008)
DOI 10.1002/sia.2726
Citations Scopus - 90Web of Science - 81
2008 Heckert EG, Karakoti AS, Seal S, Self WT, 'The role of cerium redox state in the SOD mimetic activity of nanoceria', BIOMATERIALS, 29 2705-2709 (2008)
DOI 10.1016/j.biomaterials.2008.03.014
Citations Scopus - 535Web of Science - 513
2008 Karakoti AS, Monteiro-Riviere NA, Aggarwal R, Davis JP, Narayan RJ, Self WT, et al., 'Nanoceria as antioxidant: Synthesis and biomedical applications', JOM, 60 33-37 (2008)
DOI 10.1007/s11837-008-0029-8
Citations Scopus - 261Web of Science - 233
2008 Balani K, Zhang T, Karakoti A, Li WZ, Seal S, Agarwal A, 'In situ carbon nanotube reinforcements in a plasma-sprayed aluminum oxide nanocomposite coating', ACTA MATERIALIA, 56 571-579 (2008)
DOI 10.1016/j.actamat.2007.10.038
Citations Scopus - 86Web of Science - 80
2008 Karakoti AS, Kuchibhatla SVNT, Baer DR, Thevuthasan S, Sayle DC, Seal S, 'Self-assembly of cerium oxide nanostructures in ice molds', SMALL, 4 1210-1216 (2008)
DOI 10.1002/smll.200800219
Citations Scopus - 28Web of Science - 32
2008 Sayle DC, Seal S, Wang Z, Mangili BC, Price DW, Karakoti AS, et al., 'Mapping nanostructure: A systematic enumeration of nanomaterials by assembling nanobuilding blocks at crystallographic positions', ACS NANO, 2 1237-1251 (2008)
DOI 10.1021/nn800065g
Citations Scopus - 48Web of Science - 48
2007 Kuchibhatla SVNT, Karakoti AS, Bera D, Seal S, 'One dimensional nanostructured materials', PROGRESS IN MATERIALS SCIENCE, 52 699-913 (2007)
DOI 10.1016/j.pmatsci.2006.08.001
Citations Scopus - 501Web of Science - 457
2007 Kuchibhatla SVNT, Karakoti AS, Seal S, 'Hierarchical assembly of inorganic nanostructure building blocks to octahedral superstructures - a true template-free self-assembly', NANOTECHNOLOGY, 18 (2007)
DOI 10.1088/0957-4484/18/7/075303
Citations Scopus - 38Web of Science - 38
2007 Diaz DJ, Greenletch N, Solanki A, Karakoti A, Seal S, 'Novel nanoscale ceria-platinum composite electrodes for direct alcohol electro-oxidation', CATALYSIS LETTERS, 119 319-326 (2007)
DOI 10.1007/s10562-007-9238-y
Citations Scopus - 27Web of Science - 26
2007 Deshpande S, Karakoti A, Londe G, Cho HJ, Seal S, 'Room temperature hydrogen detection using 1-d nanostructured tin oxide sensor', JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 7 3354-3357 (2007)
DOI 10.1166/jnn.2007.872
Citations Scopus - 17Web of Science - 15
2007 Vincent A, Babu S, Brinley E, Karakoti A, Deshpande S, Seal S, 'Role of catalyst on refractive index tunability of porous silica antireflective coatings by sol-gel technique', JOURNAL OF PHYSICAL CHEMISTRY C, 111 8291-8298 (2007)
DOI 10.1021/jp0700736
Citations Scopus - 100Web of Science - 92
2007 Karakoti AS, Kuchibhatla SVNT, Babu KS, Seal S, 'Direct synthesis of nanoceria in aqueous polyhydroxyl solutions', JOURNAL OF PHYSICAL CHEMISTRY C, 111 17232-17240 (2007)
DOI 10.1021/jp076164k
Citations Scopus - 84Web of Science - 81
2006 Karakoti AS, Hench LL, Seal S, 'The potential toxicity of nanomaterials - The role of surfaces', JOM, 58 77-82 (2006)
DOI 10.1007/s11837-006-0147-0
Citations Scopus - 154Web of Science - 131
2006 Karakoti AS, Filmalter R, Bera D, Kuchibhatla SVNT, Vincent A, Seal S, 'Spiral growth of one dimensional titania nanostructures using anodic oxidation', JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 6 2084-2089 (2006)
DOI 10.1166/jnn.2006.364
Citations Scopus - 7Web of Science - 4
2005 Kuchibhatla SVNT, Karakoti AS, Seal S, 'Colloidal stability by surface modification', JOM, 57 52-56 (2005)
DOI 10.1007/s11837-005-0183-1
Citations Scopus - 22Web of Science - 17
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Conference (7 outputs)

Year Citation Altmetrics Link
2014 Szymanski CJ, Mihai C, Xie Y, Munusamy P, Karakoti AS, Hu D, et al., 'Shifts in oxidation states of cerium oxide nanoparticles detected inside living cells by correlated X-ray and super resolution fluorescence microscopy', ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Dallas, TX (2014)
2014 Baer DR, Munusamy P, Smith JN, Karakoti AS, Kuchibhatla SVNT, Liu C, et al., 'Time dependent transformations of ceria and silver nanoparticles during synthesis, storage, and in biological media', ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, San Francisco, CA (2014)
2012 Bhatta UM, Ross IM, Sayle D, Sayle TXT, Karakoti A, Reid D, et al., 'Electron beam induced surface morphology changes of CeO

Hydrothermally prepared ceria cuboid nanoparticles were imaged in a 300 keV aberration corrected TEM to study the instabilities of different facets of nanoscale ceria at the atomi... [more]

Hydrothermally prepared ceria cuboid nanoparticles were imaged in a 300 keV aberration corrected TEM to study the instabilities of different facets of nanoscale ceria at the atomic level. Real-time video recording at a rate of 30fps enables to closely monitor and quantify individual atomic movements. It is proposed to use quantification of electron beam induced cation movements and reconstructions as a novel probe for measurements of oxygen surface activity with nm-scale resolution, with applications in e.g. catalysis. © 2012 IEEE.

DOI 10.1109/NANO.2012.6322226
2012 Karakoti AS, Lu Z, Sanghavi S, Wang W, Nachimuthu P, Yang P, et al., 'Direct characterization of ligand nanoparticle interaction: A combined experimental and theoretical investigation', ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, San Diego, CA (2012)
2012 Bhatta UM, Ross IM, Saghi Z, Stringfellow A, Sayle D, Sayle TXT, et al., 'Atomic motion on various surfaces of ceria nanoparticles in comparison', ELECTRON MICROSCOPY AND ANALYSIS GROUP CONFERENCE 2011 (EMAG 2011), Univ Birmingham, Birmingham, ENGLAND (2012)
DOI 10.1088/1742-6596/371/1/012007
Citations Scopus - 4Web of Science - 3
2011 Kuchibhatla SVNT, Karakoti AS, Thevuthasan S, Seal S, Baer DR, 'Influence of aging on the properties of cerium oxide nanoparticles - Implications to quantum confinement effect', Proceedings of the IEEE Conference on Nanotechnology (2011)

Cerium oxide (ceria) nanoparticles are widely studied for their current and potential use in catalytic, energy, environment protection and bio-medical applications. The performanc... [more]

Cerium oxide (ceria) nanoparticles are widely studied for their current and potential use in catalytic, energy, environment protection and bio-medical applications. The performance of ceria in most of the applications is dependent on the ability of cerium to switch between its +3 and +4 oxidation states. We synthesized ceria nanoparticles in several aqueous media and measured their oxidation states as a function of time using UV-Visible spectroscopy. By following changes in the absorption edge, we observed that sample synthesis conditions and processing history affect the oxidation state of cerium. These time dependent, environmentally induced changes in the band edge likely contribute to inconsistencies in the literature regarding quantum-confinement effects for ceria nanoparticles. © 2011 IEEE.

DOI 10.1109/NANO.2011.6144639
Citations Scopus - 3
2011 Anderson JM, Karakoti A, Diaz DJ, Seal S, 'Nanoceria-Pt composite electrodes for alcohol electrooxidation in direct alcohol fuel cells', ACS National Meeting Book of Abstracts (2011)

There has been a growing concern about finding alternative sources of energy to replace current fossil fuel dependency. As an alternative, direct alcohol fuel cells (DAFC) appear ... [more]

There has been a growing concern about finding alternative sources of energy to replace current fossil fuel dependency. As an alternative, direct alcohol fuel cells (DAFC) appear to be a promising solution. A common byproduct of the electrochemical oxidation of alcohols is carbon monoxide. Unfortunately, carbon monoxide binds very strongly to the platinum anode, poisoning the electrode. CeO 2 has shown a great ability to store and release oxygen since the cerium atom reversibly undergoes oxidation/reduction processes from Ce 4+ to Ce 3+. Results suggest that the ceria's oxygen carrying capacity has a unique ability to reduce CO poisoning. In this study nanocrystalline Pt/CeO 2 composite electrodes were fabricated to investigate the electrochemical oxidation of methanol and ethanol. It was observed that the catalytic performance oscillated with age. These results suggest that the catalytic effect depends greatly on the redox state of the ceria particles.

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Grants and Funding

Summary

Number of grants 5
Total funding $2,599,933

Click on a grant title below to expand the full details for that specific grant.


20203 grants / $2,500,000

Halloysite derived nanomaterials for environmental applications$1,500,000

Funding body: Natural Nanotech Pty Ltd

Funding body Natural Nanotech Pty Ltd
Project Team Professor Ajayan Vinu, Associate Professor Jiabao Yi, Doctor Ajay Karakoti
Scheme Research Grant
Role Investigator
Funding Start 2020
Funding Finish 2022
GNo G2000368
Type Of Funding C3111 - Aust For profit
Category 3111
UON Y

The development of advanced Nanocarbon materials from coconut shell for energy and environmental applications$900,000

Funding body: Carbonova India Private Limited

Funding body Carbonova India Private Limited
Project Team Professor Ajayan Vinu, Doctor Thava Palanisami, Doctor Gurwinder Singh, Doctor Ajay Karakoti, Associate Professor Ashish Malik, Associate Professor Jiabao Yi
Scheme Research Grant
Role Investigator
Funding Start 2020
Funding Finish 2023
GNo G2000904
Type Of Funding C3211 - International For profit
Category 3211
UON Y

Direct Acetylation of benzotrifluoride to produce trifluro methyl acetophenone with noven UON developed super acid catalyst$100,000

Funding body: Deepak Nitrite Limited

Funding body Deepak Nitrite Limited
Project Team Professor Ajayan Vinu, Doctor Venkata Dasireddy, Doctor Ajay Karakoti
Scheme Research Grant
Role Investigator
Funding Start 2020
Funding Finish 2020
GNo G2000229
Type Of Funding C3211 - International For profit
Category 3211
UON Y

20192 grants / $99,933

Functionalised halloysite-kaolinite clay for hydrogen storage application$49,967

Funding body: Andromeda Metals Limited

Funding body Andromeda Metals Limited
Project Team Professor Ajayan Vinu, Doctor Ajay Karakoti
Scheme Entrepreneurs’ Programme: Innovation Connections
Role Investigator
Funding Start 2019
Funding Finish 2019
GNo G1901228
Type Of Funding C3111 - Aust For profit
Category 3111
UON Y

Functionalised halloysite-kaolinite clay for hydrogen storage application$49,966

Funding body: Department of Industry, Innovation and Science

Funding body Department of Industry, Innovation and Science
Project Team Professor Ajayan Vinu, Doctor Ajay Karakoti
Scheme Entrepreneurs' Programme: Innovation Connections
Role Investigator
Funding Start 2019
Funding Finish 2020
GNo G1901355
Type Of Funding C2120 - Aust Commonwealth - Other
Category 2120
UON Y
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Research Supervision

Number of supervisions

Completed3
Current7

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2021 PhD Two Dimensional Perovskite Materials for High Efficiency Energy Harvesting PhD (Mechanical Engineering), Faculty of Engineering and Built Environment, The University of Newcastle Co-Supervisor
2020 PhD Drug Loaded Mesoporous Core Shell Silica Nanoparticles for Targeting and Imaging Prostate Cancer PhD (Materials Science & Eng), Faculty of Engineering and Built Environment, The University of Newcastle Co-Supervisor
2020 PhD Electrical Stimulation Properties of Carbon Nanotubes (SWNT and MWNT) for Enhanced Delivery of Wound Healing Agents PhD (Materials Science & Eng), Faculty of Engineering and Built Environment, The University of Newcastle Co-Supervisor
2020 PhD Evaluating the Ligand Mediated Enzyme Mimicking Activity and Applications of Cerium Oxide Nanoparticles PhD (Materials Science & Eng), Faculty of Engineering and Built Environment, The University of Newcastle Co-Supervisor
2020 PhD Hydrogel Scaffold for Encapsulation and Release of Functionalised Nanoparticles - A 2 Stage Controlled Release Platform for Drugs/Fungicides PhD (Engineering), Faculty of Engineering and Built Environment, The University of Newcastle Principal Supervisor
2020 PhD Nitrogen-Rich Carbon Nitrides for CO2 Capture and Other Applications PhD (Materials Science & Eng), Faculty of Engineering and Built Environment, The University of Newcastle Co-Supervisor
2019 PhD Design of Controlled Drug Delivery System Based on Nanoporous Materials for Cancer Therapy PhD (Engineering), Faculty of Engineering and Built Environment, The University of Newcastle Co-Supervisor

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2020 PhD Interaction of TiO 2 and CuO Nanoparticles with Natural Organic Matters and their Responses to Living Systems Biological Sciences, Ahmedabad University Principal Supervisor
2019 PhD Understanding the Enzyme Mimicking Activity of Fe3O4 Nanoparticles and its Application in Biosensing and Antibacterial Activity Biological Sciences, Ahmedabad University Principal Supervisor
2016 Masters Tuning the Loading and Release of Docetaxel from Silica Nanostructures: An effective Anti-Cancer Drug Delivery System Biological Sciences, Ahmedabad University Sole Supervisor
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Dr Ajay Karakoti

Position

Associate Professor
GICAN
School of Engineering
Faculty of Engineering and Built Environment

Contact Details

Email ajay.karakoti@newcastle.edu.au
Phone (02) 4055 3086
Link Research Networks

Office

Room ATC 220
Building Advanced Technology Center
Location ATC building Room 220

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