Dr Ajay Karakoti

Associate Professor

School of Engineering

Career Summary

Biography

Dr. Ajay Karakoti is a broad based materials researcher focused on the synthesis of novel bare and functionalized nanoparticles for applications in biology, catalysis and sensing. His research is focused on both the applications and detailed surface and bulk characterization of these materials. A significant portion of his research deals with developing a detailed understanding of the reaction of cerium oxide nanoparticles with reactive oxygen species and the consequence of size, structure, doping and surface functional groups on its enzyme like activity. Prior to joining GICAN he was an Associate Professor at the Ahmedabad University where taught at both the engineering and the life sciences department. He also received funding for development of a series of redox tunable cerium oxide nanoparticles for applications as natural enzymes, development of research infrastructure and a technology incubator. He has also worked in the industry at the Battelle Science and Technology India Pvt. Ltd. where he gained experience of fast paced industrial research and product development. He has worked on multiple projects based on nanomaterials and has a broad background in applications such as nanozymes, gas sensors, sol-gel antireflective coatings, corrosion protection, drug delivery, fly ash based self-cementing materials and surface functionalization of beverage filters. He has published more than 65 research articles that have been cited more than 7000 times and have an H-index of 36 (Source Google Scholar). He has been granted 3 US patents and has applied for 2 full and 1 provisional patent in India. He is also an entrepreneur and have experience in setting up and running start-up companies in India. He was the recipient of M.T. Thomas Award for outstanding post-doctoral research at the Environmental and Molecular Sciences Laboratory, PNNL, USA in 2012 and was recently (2018) awarded the NASI-Scopus Young Scientist Award in India for the category - Innovations in Engineering and Physical Sciences.


Qualifications

  • Doctor of Philosophy, University of Florida - USA

Keywords

  • Biosensors
  • Nano-biomaterials
  • Nanotechnology
  • Nanozymes
  • Surface Science
  • cerium oxide nanoparticles

Fields of Research

Code Description Percentage
100703 Nanobiotechnology 40
100712 Nanoscale Characterisation 30
030603 Colloid and Surface Chemistry 30

Professional Experience

UON Appointment

Title Organisation / Department
Associate Professor University of Newcastle
School of Engineering
Australia
Associate Professor University of Newcastle
Faculty of Engineering and Built Environment
Australia

Academic appointment

Dates Title Organisation / Department
7/01/2015 - 31/12/2018 Associate Professor Ahmedabad University
India
28/06/2010 - 7/09/2012 Postdoctorate Research Associate Pacific Northwest National Laboratory
United States

Professional appointment

Dates Title Organisation / Department
10/09/2012 - 31/10/2014 Principal Scientist Battelle Science and Technology India Pvt Ltd
India
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (2 outputs)

Year Citation Altmetrics Link
2019 Panchal D, Patel R, Siddheshwari M, Rahaman E, Patel V, Karakoti AS, 'CHAPTER 4: NP-Protein Corona Interaction: Characterization Methods and Analysis', Issues in Toxicology 80-131 (2019)

© The Royal Society of Chemistry 2019. The protein corona, as suggested throughout this book, is the term used for layers of proteins on the surfaces of materials directly in cont... [more]

© The Royal Society of Chemistry 2019. The protein corona, as suggested throughout this book, is the term used for layers of proteins on the surfaces of materials directly in contact with a milieu of proteins. These layers are formed from the specific as well as non-specific adsorption of proteins on the surfaces of materials and thus can be regarded as an upgraded name for protein adsorption. Adsorption of proteins on surfaces gained importance in the early 60 s and the field drew the attention of various researchers who characterized the adsorption of proteins on multiple surfaces. The field started to gain much more interest in the early 80 s and 90 s as the transformation from ultrafine to nanoparticle-based chemistry surfaced. Liposomes and polymeric nanoparticle interactions with protein surfaces got specific attention as strategies around drug delivery started to emerge to create adsorption-resistant nanoparticle surfaces. While the concepts emerge gradually over time, the main theme of protein corona formation remains unchanged. In this chapter, we will briefly introduce nanoparticles and the nanoparticle protein corona. Aspects of the protein corona will be discussed so that the user can correlate the basic properties of corona formation that are studied using various characterization techniques. This will be followed by a brief introduction to the sampling methods and principles of various analytical techniques excluding the optical and electron-microscopy-based imaging techniques. The reader is encouraged to refer to books and journals for details of each analytical technique as a full description is beyond the scope of this chapter. Finally, relevant characteristics and properties of the nanoparticle-protein corona interaction are discussed based on the characterization technique that will help the reader to understand the utility of such characterization techniques in practice.

DOI 10.1039/9781788016308-00080
2011 Seal S, Self W, McGinnis J, Karakoti AS, 'Nanoparticles for novel healthcare therapeutics', New Materials and Technologies for Healthcare 49-55 (2011)
DOI 10.1142/9781848165595_0004

Journal article (71 outputs)

Year Citation Altmetrics Link
2020 Kansara K, Kumar A, Karakoti AS, 'Combination of humic acid and clay reduce the ecotoxic effect of TiO

© 2019 Elsevier B.V. The series of breakthroughs that have occurred within the realm of nanotechnology have been the source of several new products and technological interventions... [more]

© 2019 Elsevier B.V. The series of breakthroughs that have occurred within the realm of nanotechnology have been the source of several new products and technological interventions. One of the most salient examples in this regard is the widespread employment of titanium dioxide (TiO2) nanoparticles across a range of consumer goods. Given that waste is generated at every stage of the consumer-product cycle (from production to disposal), many items with TiO2 nanoparticles are likely to end up being discarded into water bodies. In order to understand the interaction of TiO2 NPs with aquatic ecosystem, the ecological fate and toxicity of TiO2 NPs was studied by exposing zebrafish embryos to a combination of abiotic factors (humic acid and clay) to assess its effect on the development of zebrafish embryos. The physiological changes were correlated with genetic marker analysis to holistically understand the effect on embryos development. Derjaguin¿Landau¿Verwey¿Overbeek (DLVO) theory was used to analyze the interaction energy between TiO2 NPs and natural organic matter (NOM) for understanding the aggregation behavior of engineered nanoparticles (ENPs) in media. The study revealed that combination of HA and clay stabilized TiO2 NPs, compared to bare TiO2 and HA or clay alone. TiO2 NPs and TiO2 NPs + Clay significantly altered the expression of genes involved in development of dorsoventral axis and neural network of zebrafish embryos. However, the presence of HA and HA + clay showed protective effect on zebrafish embryo development. The complete system analysis demonstrated the possible ameliorating effects of abiotic factors on the ecotoxicity of ENPs.

DOI 10.1016/j.scitotenv.2019.134133
2019 Kansara K, Paruthi A, Misra SK, Karakoti AS, Kumar A, 'Montmorillonite clay and humic acid modulate the behavior of copper oxide nanoparticles in aqueous environment and induces developmental defects in zebrafish embryo', Environmental Pollution, 255 (2019) [C1]
DOI 10.1016/j.envpol.2019.113313
2019 Talapaneni SN, Singh G, Kim IY, AlBahily K, Al-Muhtaseb AH, Karakoti AS, et al., 'Nanostructured Carbon Nitrides for CO2 Capture and Conversion', ADVANCED MATERIALS, (2019)
DOI 10.1002/adma.201904635
Citations Scopus - 1Web of Science - 1
Co-authors Siddulunaidu Talapaneni, Inyoung Kim, Ajayan Vinu
2019 Vallabani NVS, Singh S, Karakoti AS, 'Investigating the role of ATP towards amplified peroxidase activity of Iron oxide nanoparticles in different biologically relevant buffers', Applied Surface Science, 492 337-348 (2019)

© 2019 Elsevier B.V. Evaluating the colloidal stability and enzyme mimetic nature of nanozymes at different buffer conditions is necessary to develop novel biosensing, biomedical ... [more]

© 2019 Elsevier B.V. Evaluating the colloidal stability and enzyme mimetic nature of nanozymes at different buffer conditions is necessary to develop novel biosensing, biomedical and environmental applications. It is established that Fe3O4 nanoparticles show optimum peroxidase activity at pH 4 and it has also been shown that nucleotides like ATP can exhibit synergistic effect to enhance peroxidase activity at neutral pH. In this study we show the effect of buffers, pH and presence of ATP on peroxidase activity of Fe3O4 NPs and elucidate the mechanism involved in enhanced activity at neutral pH. Fe3O4 NPs colloidal stability was assessed over a period of 72 h from acidic to neutral pH. It was explained that ¿OH radical generation from the synergistic combination of nucleotides and Fe3O4 NPs resulted in peroxidase activity at neutral pH and found that buffer concentration has a major effect on this activity. These findings challenge the existing theory of peroxidase activity demonstrated by Fe3O4 NPs at acidic pH. Moreover, the posibility can overcome the pH lacuna in designing novel biosensors and can also extend the heterogeneous Fenton reaction of Fe3O4 NPs over a wide range of pH.

DOI 10.1016/j.apsusc.2019.06.177
2019 Kuchibhatla SVNT, Karakoti AS, Vasdekis AE, Windisch CF, Seal S, Thevuthasan S, Baer DR, 'An unexpected phase transformation of ceria nanoparticles in aqueous media', JOURNAL OF MATERIALS RESEARCH, 34 465-473 (2019)
DOI 10.1557/jmr.2018.490
2019 Vallabani NVS, Singh S, Karakoti AS, 'Magnetic Nanoparticles: Current Trends and Future Aspects in Diagnostics and Nanomedicine', CURRENT DRUG METABOLISM, 20 457-472 (2019)
DOI 10.2174/1389200220666181122124458
Citations Scopus - 3Web of Science - 4
2018 Bhagat S, Vallabani NVS, Shutthanandan V, Bowden M, Karakoti AS, Singh S, 'Gold core/ceria shell-based redox active nanozyme mimicking the biological multienzyme complex phenomenon', JOURNAL OF COLLOID AND INTERFACE SCIENCE, 513 831-842 (2018)
DOI 10.1016/j.jcis.2017.11.064
Citations Scopus - 25Web of Science - 23
2018 Baer DR, Karakoti AS, Clifford CA, Minelli C, Unger WES, 'Importance of sample preparation on reliable surface characterisation of nano-objects: ISO standard 20579-4', SURFACE AND INTERFACE ANALYSIS, 50 902-906 (2018)
DOI 10.1002/sia.6490
Citations Scopus - 2Web of Science - 2
2018 Patel V, Singh M, Mayes ELH, Martinez A, Shutthanandan V, Bansal V, et al., 'Ligand-mediated reversal of the oxidation state dependent ROS scavenging and enzyme mimicking activity of ceria nanoparticles', CHEMICAL COMMUNICATIONS, 54 13973-13976 (2018)
DOI 10.1039/c8cc08355j
Citations Scopus - 7Web of Science - 7
2018 Karakoti AS, Yang P, Wang W, Patel V, Martinez A, Shutthanandan V, et al., 'Investigation of the Ligand Nanoparticle Interface: A Cryogenic Approach for Preserving Surface Chemistry', JOURNAL OF PHYSICAL CHEMISTRY C, 122 3582-3590 (2018)
DOI 10.1021/acs.jpcc.7b09930
Citations Scopus - 2Web of Science - 2
2017 Sargia B, Shah J, Singh R, Arya H, Shah M, Karakoti AS, Singh S, 'Phosphate-dependent modulation of antibacterial strategy: a redox state-controlled toxicity of cerium oxide nanoparticles', BULLETIN OF MATERIALS SCIENCE, 40 1231-1240 (2017)
DOI 10.1007/s12034-017-1480-3
Citations Scopus - 1Web of Science - 1
2017 Vallabani NVS, Karakoti AS, Singh S, 'ATP-mediated intrinsic peroxidase-like activity of Fe3O4-based nanozyme: One step detection of blood glucose at physiological pH', COLLOIDS AND SURFACES B-BIOINTERFACES, 153 52-60 (2017)
DOI 10.1016/j.colsurfb.2017.02.004
Citations Scopus - 47Web of Science - 42
2016 Singh R, Karakoti AS, Self W, Seal S, Singh S, 'Redox-Sensitive Cerium Oxide Nanoparticles Protect Human Keratinocytes from Oxidative Stress Induced by Glutathione Depletion', LANGMUIR, 32 12202-12211 (2016)
DOI 10.1021/acs.langmuir.6b03022
Citations Scopus - 33Web of Science - 31
2016 Sanghavi S, Wang W, Nandasiri MI, Karakoti AS, Wang W, Yang P, Thevuthasan S, 'Investigation of trimethylacetic acid adsorption on stoichiometric and oxygen-deficient CeO2(111) surfaces', PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 18 15625-15631 (2016)
DOI 10.1039/c6cp00855k
Citations Scopus - 2Web of Science - 2
2015 Karakoti AS, Shukla R, Shanker R, Singh S, 'Surface functionalization of quantum dots for biological applications', ADVANCES IN COLLOID AND INTERFACE SCIENCE, 215 28-45 (2015)
DOI 10.1016/j.cis.2014.11.004
Citations Scopus - 97Web of Science - 92
2015 Shah J, Purohit R, Singh R, Karakoti AS, Singh S, 'ATP-enhanced peroxidase-like activity of gold nanoparticles', JOURNAL OF COLLOID AND INTERFACE SCIENCE, 456 100-107 (2015)
DOI 10.1016/j.jcis.2015.06.015
Citations Scopus - 39Web of Science - 36
2015 Inerbaev TM, Karakoti AS, Kuchibhatla SVNT, Kumar A, Masunov AE, Seal S, 'Aqueous medium induced optical transitions in cerium oxide nanoparticles', PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 17 6217-6221 (2015)
DOI 10.1039/c4cp04961f
Citations Scopus - 10Web of Science - 8
2015 Pandya A, Tripathi A, Purohit R, Singh S, Nandasiri MI, Karakoti A, et al., 'Fluorescent magnesium nanocomplex in a protein scaffold for cell nuclei imaging applications', RSC ADVANCES, 5 94236-94240 (2015)
DOI 10.1039/c5ra18450a
Citations Scopus - 1Web of Science - 1
2014 Dowding JM, Song W, Bossy K, Karakoti A, Kumar A, Kim A, et al., 'Cerium oxide nanoparticles protect against A beta-induced mitochondrial fragmentation and neuronal cell death', CELL DEATH AND DIFFERENTIATION, 21 1622-1632 (2014)
DOI 10.1038/cdd.2014.72
Citations Scopus - 72Web of Science - 64
2013 Baer DR, Engelhard MH, Johnson GE, Laskin J, Lai J, Mueller K, et al., 'Surface characterization of nanomaterials and nanoparticles: Important needs and challenging opportunities', JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A, 31 (2013)
DOI 10.1116/1.4818423
Citations Scopus - 95Web of Science - 96
2013 Hirst SM, Karakoti A, Singh S, Self W, Tyler R, Seal S, Reilly CM, 'Bio-distribution and in vivo antioxidant effects of cerium oxide nanoparticles in mice', ENVIRONMENTAL TOXICOLOGY, 28 107-118 (2013)
DOI 10.1002/tox.20704
Citations Scopus - 152Web of Science - 138
2013 Giri S, Karakoti A, Graham RP, Maguire JL, Reilly CM, Seal S, et al., 'Nanoceria: A Rare-Earth Nanoparticle as a Novel Anti-Angiogenic Therapeutic Agent in Ovarian Cancer', PLOS ONE, 8 (2013)
DOI 10.1371/journal.pone.0054578
Citations Scopus - 117Web of Science - 104
2013 Lu Z, Karakoti A, Velarde L, Wang W, Yang P, Thevuthasan S, Wang H-F, 'Dissociative Binding of Carboxylic Acid Ligand on Nanoceria Surface in Aqueous Solution: A Joint In Situ Spectroscopic Characterization and First-Principles Study', JOURNAL OF PHYSICAL CHEMISTRY C, 117 24329-24338 (2013)
DOI 10.1021/jp4068747
Citations Scopus - 37Web of Science - 35
2013 Gaynor JD, Karakoti AS, Inerbaev T, Sanghavi S, Nachimuthu P, Shutthanandan V, et al., 'Enzyme-free detection of hydrogen peroxide from cerium oxide nanoparticles immobilized on poly(4-vinylpyridine) self-assembled monolayers', JOURNAL OF MATERIALS CHEMISTRY B, 1 3443-3450 (2013)
DOI 10.1039/c3tb20204f
Citations Scopus - 15Web of Science - 14
2012 Karakoti AS, Munusamy P, Hostetler K, Kodali V, Kuchibhatla S, Orr G, et al., 'Preparation and characterization challenges to understanding environmental and biological impacts of ceria nanoparticles', SURFACE AND INTERFACE ANALYSIS, 44 882-889 (2012)
DOI 10.1002/sia.5006
Citations Scopus - 72Web of Science - 76
2012 Shah V, Shah S, Shah H, Rispoli FJ, McDonnell KT, Workeneh S, et al., 'Antibacterial Activity of Polymer Coated Cerium Oxide Nanoparticles', PLOS ONE, 7 (2012)
DOI 10.1371/journal.pone.0047827
Citations Scopus - 52Web of Science - 44
2012 Kumar A, Devanathan R, Shutthanandan V, Kuchibhata SVNT, Karakoti AS, Yong Y, et al., 'Radiation-Induced Reduction of Ceria in Single and Polycrystalline Thin Films', JOURNAL OF PHYSICAL CHEMISTRY C, 116 361-366 (2012)
DOI 10.1021/jp209345w
Citations Scopus - 21Web of Science - 22
2012 Kuchibhata SVNT, Karakoti AS, Baer DR, Samudrala S, Engelhard MH, Amonette JE, et al., 'Influence of Aging and Environment on Nanoparticle Chemistry: Implication to Confinement Effects in Nanoceria', JOURNAL OF PHYSICAL CHEMISTRY C, 116 14108-14114 (2012)
DOI 10.1021/jp300725s
Citations Scopus - 50Web of Science - 43
2012 Turkowski V, Babu S, Le D, Kumar A, Haldar MK, Wagh AV, et al., 'Linker-Induced Anomalous Emission of Organic-Molecule Conjugated Metal-Oxide Nanoparticles', ACS NANO, 6 4854-4863 (2012)
DOI 10.1021/nn301316j
Citations Scopus - 6Web of Science - 6
2011 Anderson JM, Patel J, Karakoti AS, Greeneltch N, Diaz DJ, Seal S, 'Aging effects of nanoscale ceria in ceria-platinum composite electrodes for direct alcohol electro-oxidation', ELECTROCHIMICA ACTA, 56 2541-2545 (2011)
DOI 10.1016/j.electacta.2010.11.061
Citations Scopus - 10Web of Science - 10
2011 Alili L, Sack M, Karakoti AS, Teuber S, Puschmann K, Hirst SM, et al., 'Combined cytotoxic and anti-invasive properties of redox-active nanoparticles in tumor-stroma interactions', BIOMATERIALS, 32 2918-2929 (2011)
DOI 10.1016/j.biomaterials.2010.12.056
Citations Scopus - 122Web of Science - 118
2011 Singh S, Dosani T, Karakoti AS, Kumar A, Seal S, Self WT, 'A phosphate-dependent shift in redox state of cerium oxide nanoparticles and its effects on catalytic properties', BIOMATERIALS, 32 6745-6753 (2011)
DOI 10.1016/j.biomaterials.2011.05.073
Citations Scopus - 142Web of Science - 137
2011 Kong L, Cai X, Zhou X, Wong LL, Karakoti AS, Seal S, McGinnis JF, 'Nanoceria extend photoreceptor cell lifespan in tubby mice by modulation of apoptosis/survival signaling pathways', NEUROBIOLOGY OF DISEASE, 42 514-523 (2011)
DOI 10.1016/j.nbd.2011.03.004
Citations Scopus - 99Web of Science - 98
2011 Karakoti AS, Das S, Thevuthasan S, Seal S, 'PEGylated Inorganic Nanoparticles', ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50 1980-1994 (2011)
DOI 10.1002/anie.201002969
Citations Scopus - 343Web of Science - 335
2011 Zhou X, Wong LL, Karakoti AS, Seal S, McGinnis JF, 'Nanoceria Inhibit the Development and Promote the Regression of Pathologic Retinal Neovascularization in the Vldlr Knockout Mouse', PLOS ONE, 6 (2011)
DOI 10.1371/journal.pone.0016733
Citations Scopus - 98Web of Science - 87
2011 Baer DR, Karakoti AS, Munusamy P, Thrall BD, Pounds JG, Teeguarden JG, et al., 'Testing in EHS: What is the current status of experimentation?', Proceedings of the IEEE Conference on Nanotechnology, 18-19 (2011)

This paper explores some of the fundamental and practical issues related to the behavior of nanoparticles in the environment and their potential impacts on human health. In our re... [more]

This paper explores some of the fundamental and practical issues related to the behavior of nanoparticles in the environment and their potential impacts on human health. In our research we have explored the reactive behaviors of nanoparticles with contaminants in the environment, how nanoparticle change in response to their environment and time, and how nanoparticles interact with biological systems of various types. It has become apparent that researchers often underestimate the difficulties of preparing and delivering well characterized nanoparticles for specific types of testing or applications. Difficulties arise in areas that range from not understanding what imparts the nano character of a particle to not knowing the impacts of minor species on the properties of high surface area materials. Some of our adventures and misadventures serve as examples of some of these issues as they relate to providing well defined particles for biological studies. © 2011 IEEE.

DOI 10.1109/NANO.2011.6144671
2011 Karakoti AS, Sanghavi S, Nachimuthu P, Yang P, Thevuthasan S, 'Probing the Size- and Environment-Induced Phase Transformation in CdSe Quantum Dots', JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2 2925-2929 (2011)
DOI 10.1021/jz201243t
Citations Scopus - 19Web of Science - 18
2011 Shirato N, Strader J, Kumar A, Vincent A, Zhang P, Karakoti A, et al., 'Thickness dependent self limiting 1-D tin oxide nanowire arrays by nanosecond pulsed laser irradiation', NANOSCALE, 3 1090-1101 (2011)
DOI 10.1039/c0nr00689k
Citations Scopus - 10Web of Science - 11
2011 Sayle TXT, Inkson BJ, Karakoti A, Kumar A, Molinari M, Moebus G, et al., 'Mechanical properties of ceria nanorods and nanochains; the effect of dislocations, grain-boundaries and oriented attachment', NANOSCALE, 3 1823-1837 (2011)
DOI 10.1039/c0nr00980f
Citations Scopus - 30Web of Science - 29
2010 Singh V, Karakoti A, Kumar A, Saha A, Basu S, Seal S, 'Precursor Dependent Microstructure Evolution and Nonstoichiometry in Nanostructured Cerium Oxide Coatings Using the Solution Precursor Plasma Spray Technique', JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 93 3700-3708 (2010)
DOI 10.1111/j.1551-2916.2010.03985.x
Citations Scopus - 16Web of Science - 11
2010 Karakoti A, Singh S, Dowding JM, Seal S, Self WT, 'Redox-active radical scavenging nanomaterials', CHEMICAL SOCIETY REVIEWS, 39 4422-4432 (2010)
DOI 10.1039/b919677n
Citations Scopus - 288Web of Science - 280
2010 Sharma RK, Karakoti A, Seal S, Zhai L, 'Multiwall carbon nanotube-poly(4-styrenesulfonic acid) supported polypyrrole/manganese oxide nano-composites for high performance electrochemical electrodes', JOURNAL OF POWER SOURCES, 195 1256-1262 (2010)
DOI 10.1016/j.jpowsour.2009.08.093
Citations Scopus - 78Web of Science - 74
2010 Vincent A, Inerbaev TM, Babu S, Karakoti AS, Self WT, Masunov AE, Seal S, 'Tuning Hydrated Nanoceria Surfaces: Experimental/Theoretical Investigations of Ion Exchange and Implications in Organic and Inorganic Interactions', LANGMUIR, 26 7188-7198 (2010)
DOI 10.1021/la904285g
Citations Scopus - 27Web of Science - 24
2010 Karakoti AS, King JES, Vincent A, Seal S, 'Synthesis dependent core level binding energy shift in the oxidation state of platinum coated on ceria-titania and its effect on catalytic decomposition of methanol', APPLIED CATALYSIS A-GENERAL, 388 262-271 (2010)
DOI 10.1016/j.apcata.2010.08.060
Citations Scopus - 19Web of Science - 21
2010 Karakoti AS, Tsigkou O, Yue S, Lee PD, Stevens MM, Jones JR, Seal S, 'Rare earth oxides as nanoadditives in 3-D nanocomposite scaffolds for bone regeneration', JOURNAL OF MATERIALS CHEMISTRY, 20 8912-8919 (2010)
DOI 10.1039/c0jm01072c
Citations Scopus - 70Web of Science - 68
2010 Pirmohamed T, Dowding JM, Singh S, Wasserman B, Heckert E, Karakoti AS, et al., 'Nanoceria exhibit redox state-dependent catalase mimetic activity', CHEMICAL COMMUNICATIONS, 46 2736-2738 (2010)
DOI 10.1039/b922024k
Citations Scopus - 497Web of Science - 469
2010 Singh V, Babu S, Karakoti AS, Agarwal A, Seal S, 'Effect of Submicron Grains on Ionic Conductivity of Nanocrystalline Doped Ceria', JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 10 6495-6503 (2010)
DOI 10.1166/jnn.2010.2523
Citations Scopus - 23Web of Science - 26
2010 Singh S, Kumar A, Karakoti A, Seal S, Self WT, 'Unveiling the mechanism of uptake and sub-cellular distribution of cerium oxide nanoparticles', MOLECULAR BIOSYSTEMS, 6 1813-1820 (2010)
DOI 10.1039/c0mb00014k
Citations Scopus - 101Web of Science - 94
2010 Anderson J, Karakoti A, Diaz DJ, Seal S, 'Nanoceria-Modified Platinum-Gold Composite Electrodes for the Electrochemical Oxidation of Methanol and Ethanol in Acidic Media', JOURNAL OF PHYSICAL CHEMISTRY C, 114 4595-4602 (2010)
DOI 10.1021/jp911099r
Citations Scopus - 21Web of Science - 20
2010 Zou J, Liu J, Karakoti AS, Kumar A, Joung D, Li Q, et al., 'Ultralight Multiwalled Carbon Nanotube Aerogel', ACS NANO, 4 7293-7302 (2010)
DOI 10.1021/nn102246a
Citations Scopus - 329Web of Science - 323
2009 Karakoti AS, Singh S, Kumar A, Malinska M, Kuchibhatla SVNT, Wozniak K, et al., 'PEGylated Nanoceria as Radical Scavenger with Tunable Redox Chemistry', JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131 14144-14145 (2009)
DOI 10.1021/ja9051087
Citations Scopus - 202Web of Science - 197
2009 Kumar A, Babu S, Karakoti AS, Schulte A, Seal S, 'Luminescence Properties of Europium-Doped Cerium Oxide Nanoparticles: Role of Vacancy and Oxidation States', LANGMUIR, 25 10998-11007 (2009)
DOI 10.1021/la901298q
Citations Scopus - 179Web of Science - 169
2009 Kuchibhatla SVNT, Karakoti AS, Sayle DC, Heinrich H, Seal S, 'Symmetry-Driven Spontaneous Self-Assembly of Nanoscale Ceria Building Blocks to Fractal Superoctahedra', CRYSTAL GROWTH & DESIGN, 9 1614-1620 (2009)
DOI 10.1021/cg801358z
Citations Scopus - 16Web of Science - 17
2009 Hirst SM, Karakoti AS, Tyler RD, Sriranganathan N, Seal S, Reilly CM, 'Anti-inflammatory Properties of Cerium Oxide Nanoparticles', SMALL, 5 2848-2856 (2009)
DOI 10.1002/smll.200901048
Citations Scopus - 379Web of Science - 359
2009 Schanen BC, Karakoti AS, Seal S, Drake DR, Warren WL, Self WT, 'Exposure to Titanium Dioxide Nanomaterials Provokes Inflammation of an in Vitro Human Immune Construct', ACS NANO, 3 2523-2532 (2009)
DOI 10.1021/nn900403h
Citations Scopus - 110Web of Science - 103
2009 Bhargava N, Das M, Karakoti AS, Patil S, Kang JF, Stancescu M, et al., 'Regeneration of adult mice motoneurons utilizing a defined system and anti-oxidant nanoparticles', Journal of Nanoneuroscience, 1 130-143 (2009)

We have developed a novel culture model to grow adult mice spinal cord cells. The model consisted of a serum-free medium supplemented with different growth factors, nanoparticles ... [more]

We have developed a novel culture model to grow adult mice spinal cord cells. The model consisted of a serum-free medium supplemented with different growth factors, nanoparticles and a silane substrate. The following growth factors and nanoparticles constitute the novel serum-free medium: Acidic FGF, Heparan-Sulphate, GDNF, BDNF, CNTF, CT-1, NT-3, NT-4, VEGF, LIF, Vitronectin, B27 supplement, G5 supplement and Cerium oxide nanoparticles. Synergistic effects of these growth factors, nanoparticles and silane substrate promote survival and growth of spinal-cord neurons and glial cells. Based on the cell body size, number of processes and process lengths the cells were categorized into three different groups: Groups I, II and III. Apart from these three cell groups, some of the cells grew in clumps. We categorized the clumps as Group IV. Cells were immunocytochemically characterized by antibodies against NF-150 and GFAP. The cells in Group I, which were found in a small percentage (~10%) in each culture, were then further characterized. These cells had large, multi-polar, cell bodies (30-35 µm) and long processes (~500-800 µm) and they also stained positive for all three motoneuron specific antibodies; ChAT, Islet-1 and MO-1. Based on morphological and immunocytochemical analysis it was concluded that this small percentage of large, multi-polar cells were regenerating motoneurons. Preliminary electrophysiological studies indicated that the cells with this neuronal morphology fired single action potentials. This novel model system could be used as a tool to study spinal injuries and neurodegenerative diseases of aging spinal cord. Copyright © 2009 American Scientific Publishers. All rights reserved.

DOI 10.1166/jns.2009.1002
Citations Scopus - 8
2008 Baer DR, Amonette JE, Engelhard MH, Gaspar DJ, Karakoti AS, Kuchibhatla S, et al., 'Characterization challenges for nanomaterials', SURFACE AND INTERFACE ANALYSIS, 40 529-537 (2008)
DOI 10.1002/sia.2726
Citations Scopus - 81Web of Science - 75
2008 Heckert EG, Karakoti AS, Seal S, Self WT, 'The role of cerium redox state in the SOD mimetic activity of nanoceria', BIOMATERIALS, 29 2705-2709 (2008)
DOI 10.1016/j.biomaterials.2008.03.014
Citations Scopus - 489Web of Science - 465
2008 Karakoti AS, Monteiro-Riviere NA, Aggarwal R, Davis JP, Narayan RJ, Self WT, et al., 'Nanoceria as antioxidant: Synthesis and biomedical applications', JOM, 60 33-37 (2008)
DOI 10.1007/s11837-008-0029-8
Citations Scopus - 240Web of Science - 213
2008 Balani K, Zhang T, Karakoti A, Li WZ, Seal S, Agarwal A, 'In situ carbon nanotube reinforcements in a plasma-sprayed aluminum oxide nanocomposite coating', ACTA MATERIALIA, 56 571-579 (2008)
DOI 10.1016/j.actamat.2007.10.038
Citations Scopus - 83Web of Science - 75
2008 Karakoti AS, Kuchibhatla SVNT, Baer DR, Thevuthasan S, Sayle DC, Seal S, 'Self-assembly of cerium oxide nanostructures in ice molds', SMALL, 4 1210-1216 (2008)
DOI 10.1002/smll.200800219
Citations Scopus - 26Web of Science - 30
2008 Sayle DC, Seal S, Wang Z, Mangili BC, Price DW, Karakoti AS, et al., 'Mapping nanostructure: A systematic enumeration of nanomaterials by assembling nanobuilding blocks at crystallographic positions', ACS NANO, 2 1237-1251 (2008)
DOI 10.1021/nn800065g
Citations Scopus - 45Web of Science - 45
2007 Kuchibhatla SVNT, Karakoti AS, Bera D, Seal S, 'One dimensional nanostructured materials', PROGRESS IN MATERIALS SCIENCE, 52 699-913 (2007)
DOI 10.1016/j.pmatsci.2006.08.001
Citations Scopus - 480Web of Science - 438
2007 Kuchibhatla SVNT, Karakoti AS, Seal S, 'Hierarchical assembly of inorganic nanostructure building blocks to octahedral superstructures - a true template-free self-assembly', NANOTECHNOLOGY, 18 (2007)
DOI 10.1088/0957-4484/18/7/075303
Citations Scopus - 38Web of Science - 37
2007 Diaz DJ, Greenletch N, Solanki A, Karakoti A, Seal S, 'Novel nanoscale ceria-platinum composite electrodes for direct alcohol electro-oxidation', CATALYSIS LETTERS, 119 319-326 (2007)
DOI 10.1007/s10562-007-9238-y
Citations Scopus - 27Web of Science - 26
2007 Deshpande S, Karakoti A, Londe G, Cho HJ, Seal S, 'Room temperature hydrogen detection using 1-d nanostructured tin oxide sensor', JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 7 3354-3357 (2007)
DOI 10.1166/jnn.2007.872
Citations Scopus - 17Web of Science - 15
2007 Vincent A, Babu S, Brinley E, Karakoti A, Deshpande S, Seal S, 'Role of catalyst on refractive index tunability of porous silica antireflective coatings by sol-gel technique', JOURNAL OF PHYSICAL CHEMISTRY C, 111 8291-8298 (2007)
DOI 10.1021/jp0700736
Citations Scopus - 94Web of Science - 86
2007 Karakoti AS, Kuchibhatla SVNT, Babu KS, Seal S, 'Direct synthesis of nanoceria in aqueous polyhydroxyl solutions', JOURNAL OF PHYSICAL CHEMISTRY C, 111 17232-17240 (2007)
DOI 10.1021/jp076164k
Citations Scopus - 79Web of Science - 74
2006 Karakoti AS, Hench LL, Seal S, 'The potential toxicity of nanomaterials - The role of surfaces', JOM, 58 77-82 (2006)
DOI 10.1007/s11837-006-0147-0
Citations Scopus - 143Web of Science - 124
2006 Karakoti AS, Filmalter R, Bera D, Kuchibhatla SVNT, Vincent A, Seal S, 'Spiral growth of one dimensional titania nanostructures using anodic oxidation', JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 6 2084-2089 (2006)
DOI 10.1166/jnn.2006.364
Citations Scopus - 7Web of Science - 3
2005 Kuchibhatla SVNT, Karakoti AS, Seal S, 'Colloidal stability by surface modification', JOM, 57 52-56 (2005)
DOI 10.1007/s11837-005-0183-1
Citations Scopus - 21Web of Science - 15
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Conference (7 outputs)

Year Citation Altmetrics Link
2014 Szymanski CJ, Mihai C, Xie Y, Munusamy P, Karakoti AS, Hu D, et al., 'Shifts in oxidation states of cerium oxide nanoparticles detected inside living cells by correlated X-ray and super resolution fluorescence microscopy', ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Dallas, TX (2014)
2014 Baer DR, Munusamy P, Smith JN, Karakoti AS, Kuchibhatla SVNT, Liu C, et al., 'Time dependent transformations of ceria and silver nanoparticles during synthesis, storage, and in biological media', ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, San Francisco, CA (2014)
2012 Bhatta UM, Ross IM, Sayle D, Sayle TXT, Karakoti A, Reid D, et al., 'Electron beam induced surface morphology changes of CeO

Hydrothermally prepared ceria cuboid nanoparticles were imaged in a 300 keV aberration corrected TEM to study the instabilities of different facets of nanoscale ceria at the atomi... [more]

Hydrothermally prepared ceria cuboid nanoparticles were imaged in a 300 keV aberration corrected TEM to study the instabilities of different facets of nanoscale ceria at the atomic level. Real-time video recording at a rate of 30fps enables to closely monitor and quantify individual atomic movements. It is proposed to use quantification of electron beam induced cation movements and reconstructions as a novel probe for measurements of oxygen surface activity with nm-scale resolution, with applications in e.g. catalysis. © 2012 IEEE.

DOI 10.1109/NANO.2012.6322226
2012 Karakoti AS, Lu Z, Sanghavi S, Wang W, Nachimuthu P, Yang P, et al., 'Direct characterization of ligand nanoparticle interaction: A combined experimental and theoretical investigation', ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, San Diego, CA (2012)
2012 Bhatta UM, Ross IM, Saghi Z, Stringfellow A, Sayle D, Sayle TXT, et al., 'Atomic motion on various surfaces of ceria nanoparticles in comparison', ELECTRON MICROSCOPY AND ANALYSIS GROUP CONFERENCE 2011 (EMAG 2011), Univ Birmingham, Birmingham, ENGLAND (2012)
DOI 10.1088/1742-6596/371/1/012007
Citations Scopus - 4Web of Science - 3
2011 Kuchibhatla SVNT, Karakoti AS, Thevuthasan S, Seal S, Baer DR, 'Influence of aging on the properties of cerium oxide nanoparticles - Implications to quantum confinement effect', Proceedings of the IEEE Conference on Nanotechnology (2011)

Cerium oxide (ceria) nanoparticles are widely studied for their current and potential use in catalytic, energy, environment protection and bio-medical applications. The performanc... [more]

Cerium oxide (ceria) nanoparticles are widely studied for their current and potential use in catalytic, energy, environment protection and bio-medical applications. The performance of ceria in most of the applications is dependent on the ability of cerium to switch between its +3 and +4 oxidation states. We synthesized ceria nanoparticles in several aqueous media and measured their oxidation states as a function of time using UV-Visible spectroscopy. By following changes in the absorption edge, we observed that sample synthesis conditions and processing history affect the oxidation state of cerium. These time dependent, environmentally induced changes in the band edge likely contribute to inconsistencies in the literature regarding quantum-confinement effects for ceria nanoparticles. © 2011 IEEE.

DOI 10.1109/NANO.2011.6144639
Citations Scopus - 3
2011 Anderson JM, Karakoti A, Diaz DJ, Seal S, 'Nanoceria-Pt composite electrodes for alcohol electrooxidation in direct alcohol fuel cells', ACS National Meeting Book of Abstracts (2011)

There has been a growing concern about finding alternative sources of energy to replace current fossil fuel dependency. As an alternative, direct alcohol fuel cells (DAFC) appear ... [more]

There has been a growing concern about finding alternative sources of energy to replace current fossil fuel dependency. As an alternative, direct alcohol fuel cells (DAFC) appear to be a promising solution. A common byproduct of the electrochemical oxidation of alcohols is carbon monoxide. Unfortunately, carbon monoxide binds very strongly to the platinum anode, poisoning the electrode. CeO 2 has shown a great ability to store and release oxygen since the cerium atom reversibly undergoes oxidation/reduction processes from Ce 4+ to Ce 3+. Results suggest that the ceria's oxygen carrying capacity has a unique ability to reduce CO poisoning. In this study nanocrystalline Pt/CeO 2 composite electrodes were fabricated to investigate the electrochemical oxidation of methanol and ethanol. It was observed that the catalytic performance oscillated with age. These results suggest that the catalytic effect depends greatly on the redox state of the ceria particles.

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Grants and Funding

Summary

Number of grants 2
Total funding $99,933

Click on a grant title below to expand the full details for that specific grant.


20192 grants / $99,933

Functionalised halloysite-kaolinite clay for hydrogen storage application$49,967

Funding body: Andromeda Metals Limited

Funding body Andromeda Metals Limited
Project Team Professor Ajayan Vinu, Doctor Ajay Karakoti
Scheme Entrepreneurs’ Programme: Innovation Connections
Role Investigator
Funding Start 2019
Funding Finish 2019
GNo G1901228
Type Of Funding C3111 - Aust For profit
Category 3111
UON Y

Functionalised halloysite-kaolinite clay for hydrogen storage application$49,966

Funding body: Department of Industry, Innovation and Science

Funding body Department of Industry, Innovation and Science
Project Team Professor Ajayan Vinu, Doctor Ajay Karakoti
Scheme Entrepreneurs' Programme: Innovation Connections
Role Investigator
Funding Start 2019
Funding Finish 2020
GNo G1901355
Type Of Funding C2120 - Aust Commonwealth - Other
Category 2120
UON Y
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Research Supervision

Number of supervisions

Completed2
Current5

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2019 PhD Nitrogen-Rich Carbon Nitrides for CO2 Capture and Other Applications PhD (Engineering), Faculty of Engineering and Built Environment, The University of Newcastle Co-Supervisor
2019 PhD Design of Controlled Drug Delivery System Based on Nanoporous Materials for Cancer Therapy PhD (Engineering), Faculty of Engineering and Built Environment, The University of Newcastle Co-Supervisor
2018 PhD Photoinduced Interface Charge Transfer Studies Between 2D/0D Hybrid Heterostructures for Excitonic Solar Cell Applications PhD (Engineering), Faculty of Engineering and Built Environment, The University of Newcastle Co-Supervisor
2017 PhD Drug Loaded Mesoporous Core Shell Silica Nanoparticles for Targeting and Imaging Prostate Cancer PhD (Engineering), Faculty of Engineering and Built Environment, The University of Newcastle Co-Supervisor
2016 PhD Interaction of TiO 2 and CuO Nanoparticles with Natural Organic Matters and their Responses to Living Systems Biological Sciences, Ahmedabad University Principal Supervisor

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2019 PhD Understanding the Enzyme Mimicking Activity of Fe3O4 Nanoparticles and its Application in Biosensing and Antibacterial Activity Biological Sciences, Ahmedabad University Principal Supervisor
2016 Masters Tuning the Loading and Release of Docetaxel from Silica Nanostructures: An effective Anti-Cancer Drug Delivery System Biological Sciences, Ahmedabad University Sole Supervisor
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Dr Ajay Karakoti

Position

Associate Professor
GICAN
School of Engineering
Faculty of Engineering and Built Environment

Contact Details

Email ajay.karakoti@newcastle.edu.au
Phone (02) 4055 3086
Link Research Networks

Office

Room ATC 220
Building Advanced Technology Center
Location ATC building Room 220

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