Staff Profile
Conjoint Associate Professor Vicki Clifton
Conjoint Associate Professor
School of Medicine and Public Health
EditCareer Summary
Biography
I have a strong background in fetal growth, reproductive endocrinology and placental physiology. My research has examined aspects of placental and myometrial function. I also have strengths in fetal physiology from my postdoctoral work at the University of Toronto, Canada working with leading fetal physiologist, Prof John Challis and with the study of the effect of asthma during pregnancy on placental function and fetal development. My research interests have evolved into an investigation of those factors that program fetal development, in particular activation of the immune system.
I presently conduct my research both independently and as a team member. As an initiative, I identified asthma as a common condition in pregnancy involving inflammation that might provide a valuable model in which to study the effects of an inflammatory process on the outcome of the pregnancy. Our results have been startling, identifying an important sex dependent difference in the fetal growth response to maternal asthma. The results have lead to many prizes for my students, publications in the asthma and obstetric literature and reviews in high impact factor journals such as Endocrine Reviews. Clinically this study has demonstrated that asthmatic women require extra care during their pregnancies and resulted in funding by NHMRC (2007-2010) for a randomized control trial for treatment regimes specifically for pregnant asthmatic women. Scientifically this work has started to create a picture of what sex specific factors are involved in preterm delivery and fetal development in pathological pregnancies. This work has been generously funded by The Asthma Foundation of NSW for the last 10 years and by an NHMRC priming grant and project grant for the last 6 years. I was the sole investigator on these grants.
I was awarded The Arthur Wilson Memorial Fellowship for 2002-2003 from the Royal Australian and New Zealand Society of Obstetricians and Gynaecologists, and an NHMRC Career Development Award (2004-2009) for this work. I received the Gabor Than Award in Placentology from the International Federation of Placental Associations in 2003 for my asthma and pregnancy research and presented in a plenary session at the annual meeting in Mainz 2003.
The most exciting aspect of doing the research in asthma and pregnancy is to find that our work has had a clinical impact and has contributed to the formulation of the NIH American Guidelines for the treatment of asthma during pregnancy (J Allergy Clin Immunol 2005; 115:34-46). My asthma and pregnancy research has a wide audience as the work has been presented at both international thoracic societies and international societies associated with reproduction and fetal growth.
I have published consistently every year over the last five years in medium to high impact journals related to my field. These are specialized contributions in internationally recognized journals in both obstetric and respiratory fields. I am consistently invited each year to present my work in plenary sessions and I regularly Chair conference sessions. I am the Treasurer of the Endocrine Society of Australia (2004-present). I am Executive member of the International Federations of Placental Associations since 2001. My leadership skills in research and research training have been recognized with my promotion to Associate Professor and Deputy Director of Mothers and Babies Research Centre.
Qualifications
- PhD, University of Newcastle
- Bachelor of Science (Honours), University of Newcastle
Research
Research keywords
- Fetal physiology
- Neonatal cardiovascular adapatation
- Placental physiology
- asthma
- pregnancy
Research expertise
My work is based in a clinical setting with a focus on Human maternal-fetal-neonatal medical research. All of my primary studies involve prospectively following pregnant women and their children and examining mechanism that influence fetal growth and survival
Fields of Research
| Code | Description | Percentage |
|---|
| 111400 | Paediatrics And Reproductive Medicine | 50 |
| 110299 | Cardiovascular Medicine And Haematology Not Elsewhere Classified | 25 |
| 110300 | Clinical Sciences | 25 |
Memberships
Committee/Associations (relevant to research).
-
Australian Society of Medical research
-
Developmental Origins of Adult Disease
- Executive committee member, Treasurer - Endocrine Society of Australia
- Executive committee member - International Federation of Placental Associations
- NHMRC GRP panel member - Obstetric/gynaecology/paediatric/neonatal GRP
-
Perinatal Society of Australia and New Zealand
-
Society of Gynecologic Investigation
Appointments
Fellowship National Health & Medical Research Council (Australia) | 01/01/2004 - 01/12/2008 |
research Development manager P/T 0.2 University of newcastle (Australia) | 01/01/2004 - 01/12/2004 |
Treasurer Endocrine Society of Australia (Australia) | 01/09/2004 - 01/12/2007 |
Awards
Research Award.
| 2003 | Gabor Than Award in Placentology International Federation of Placental Associations (Germany) Awarded for my work in asthma and pregnancy |
|---|
Invitations
Plenary speaker International federation of placental associations, Germany (Conference Presentation - non published.)
| 2003 |
Administrative
Administrative expertise
I have worked as a research development manager for the Faculty of Health and I am the deputy director of the Mothers and Babies research centre and in the Reproductive Sciences PRC. My admin involves leadership and management roles within these centres.
Teaching
Teaching keywords
- Reproductive physiology
- endocrinology
- fetal physiology
- neonatal development
Teaching expertise
I am predominantly focussed on postgraduate teaching with Honours, masters and PhD students
EditPublications
No publications.
EditGrants and Funding
Summary
| Number of grants | 53 |
|---|
| Total funding | $4,637,152 |
|---|
For project grants received where the lead institution is other than the University of Newcastle, details are shown in italics.
- Indicates that the researcher may be seeking students for this project.
Click on a grant title below to expand the full details for that specific grant.
2009 (2 grants)
The Ontogeny of Pain Behaviour: A Novel Neuroimmune Pathway.$150,000
Funding Body: ARC (Australian Research Council)
The role of early life infection in the predisposition to anxiety in adulthood$20,000
Funding Body: University of Newcastle
2008 (2 grants)
Research Fellowship$537,500
Funding Body: NHMRC (National Health & Medical Research Council)
Characterisation of Cardiovascular Adaptation in Newborn Infants$38,336
Funding Body: Hunter Medical Research Institute
2007 (8 grants)
Managing asthma in pregnancy: the MAP study$805,875
Funding Body: NHMRC (National Health & Medical Research Council)
HMRI 07-33 Maternal asthma and the growth and survival of infants$590,751
Funding Body: Hunter Medical Research Institute
Role of p38 MAPK in regulating sex specific placental glucocorticoid receptor function in pregnancies complicated by asthma$50,000
Funding Body: Asthma Foundation of New South Wales
Nitric Oxide Monitoring System (NIOX)$45,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team |
|---|
| Conjoint Professor Peter Gibson, Conjoint Associate Professor Vicki Clifton, Conjoint Professor Warwick Giles, Emeritus Professor Michael Hensley, Doctor Vanessa Murphy, Conjoint Associate Professor Peter Wark, Doctor Vanessa McDonald, Associate Professor Jodie Simpson, Conjoint Associate Professor Bruce Whitehead, Professor Paul Foster, Professor Phil Hansbro, Associate Professor Lisa Wood |
| Scheme | Role |
|---|
| Equipment Grant | Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $45,000 | 2007 | 2007 |
| GNo:G0188193 |
Beta Radiation Counter Instrument facility$25,670
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team |
|---|
| Professor Roger Smith, Conjoint Associate Professor Vicki Clifton, Conjoint Professor Tam Zakar, Conjoint Associate Professor Rick Nicholson, Dr Mark Read, Doctor Cheng Chan, Doctor John Fitter, Conjoint Associate Professor Andrew Bisits, Associate Professor Jon Hirst, Doctor Hannah Palliser, Conjoint Professor Ian Symonds |
| Scheme | Role |
|---|
| Equipment Grant | Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $25,670 | 2007 | 2007 |
| GNo:G0188194 |
Hewlett Packard 7890 series gas chromatograph with accessories$20,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team |
|---|
| Associate Professor Lisa Wood, Conjoint Associate Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Doctor Vanessa Murphy, Professor Paul Foster, Professor Phil Hansbro, Conjoint Associate Professor Vicki Clifton, Professor Clare Collins, Conjoint Professor Wayne Smith, Professor John Attia |
| Scheme | Role |
|---|
| Equipment Grant | Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $20,000 | 2007 | 2007 |
| GNo:G0188191 |
Artist-in-Residence Project$10,000
Funding Body: John Boulton
International Federation of Placetal Associations, Kingston Conference Centre, Ontario, Canada, 17/8/2007 - 23/8/2007$2,500
Funding Body: University of Newcastle
2006 (8 grants)
PRC - Priority Research Centre for Reproductive Science$544,282
Funding Body: University of Newcastle
| Project Team |
|---|
| Laureate Professor John Aitken, Professor Roger Smith, Professor Eileen McLaughlin, Associate Professor Brett Nixon, Doctor Shaun Roman, Conjoint Associate Professor Vicki Clifton, Conjoint Professor Warwick Giles, Associate Professor Jon Hirst, Conjoint Associate Professor Rick Nicholson, Conjoint Professor Ian Symonds |
| Scheme | Role |
|---|
| Priority Research Centre | Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $544,282 | 2006 | 2013 |
| GNo:G0186945 |
The effect of maternal asthma and its treatment on placental and fetal glucocorticoid receptor expression$50,000
Funding Body: Asthma Foundation of New South Wales
The relationship between eosinophilic inflammation, viral infection and severe asthma exacerbations during pregnancy$50,000
Funding Body: Asthma Foundation of New South Wales
Viral infections and asthma exacerbations during pregnancy: characteristics, mechanisms and consequences$19,100
Funding Body: University of Newcastle
Effect of Maternal Asthma during Pregnancy on the Fetal Immune System$18,837
Funding Body: Asthma Foundation of New South Wales
Neurosteroids in the neonatal brain: potential role in protecting against perinatal brain injury$16,000
Funding Body: Hunter Medical Research Institute
Perinatal programming of human anxiety disorders$16,000
Funding Body: Hunter Medical Research Institute
Maternal asthma during pregnancy alters placental and fetal response to glucocorticoid in a sexually dimorphic manner$10,000
Funding Body: University of Newcastle
2005 (4 grants)
Effect of maternal asthma during pregnancy on the fetal immune system$18,837
Funding Body: Asthma Foundation of New South Wales
Perinatal programming of the neuroendocrine and immune system: Implications for long term health outcomes$6,029
Funding Body: University of Newcastle
The effect of maternal infection on predisposition towards asthma in adulthood$6,029
Funding Body: University of Newcastle
DoHAD - 3rd International Congress on $1,910
Funding Body: University of Newcastle
2004 (4 grants)
The effect of asthma during pregnancy on placental function and fetal development$417,500
Funding Body: NHMRC (National Health & Medical Research Council)
Perinatal neuroendocrine programming of adult immunocompetence$12,000
Funding Body: University of Newcastle
The effect of maternal inflammation on fetal development, placental function and neonatal immune competence: An animal model of asthma during pregnancy$10,000
Funding Body: University of Newcastle
Society of Gynecologic Investigation, 24-28 March 2004, USA$2,400
Funding Body: University of Newcastle
2003 (5 grants)
The effect of asthma during pregnancy on placental function and fetal development$360,000
Funding Body: NHMRC (National Health & Medical Research Council)
Sievers NOA 280i Nitric Oxide Analyser$36,650
Funding Body: NHMRC (National Health & Medical Research Council)
Use of SELDI-TOF-MS to identify proteins relevant to human labour$17,000
Funding Body: University of Newcastle
The effect of prenatal exposure to bacteria on placental 11?-HSD activity in the guinea pig: a potential mechanism for altered stress sensitivity in adulthood$11,500
Funding Body: University of Newcastle
Society of Gynecologic Investigation, Washinton DC, USA 25 - 30 March, 2003$2,400
Funding Body: University of Newcastle
2002 (4 grants)
Effect of fetal factors on maternal asthma and fetal outcome.$56,842
Funding Body: Asthma Foundation of New South Wales
The Impact of Asthma During Pregnancy on Placental Function.$40,000
Funding Body: Royal Australian and New Zealand College of Obstetricians and Gynaecologists
Effect of pregnancy on maternal asthma, placental function and fetal development.$5,000
Funding Body: Asthma Foundation of New South Wales
International Federation of Placental Associations Annual Conference, Melbourne 6-10 October, 2002$1,706
Funding Body: University of Newcastle
2001 (4 grants)
Beckman Coulter HPLC Detector and software. Extech circulation heating bath with accessories and software$19,000
Funding Body: NHMRC (National Health & Medical Research Council)
Beckman Coulter HPLC Detector and software. Extech circulation heating bath with accessories and software$10,836
Funding Body: University of Newcastle
Visit of Dr Qing Gu from 1 August 2001 to 1 November 2001$3,921
Funding Body: University of Newcastle
Annual meeting of Society Gynecologic Investigation, Canada 9-19 March 2001$2,244
Funding Body: University of Newcastle
2000 (3 grants)
The impact of servere asthma during pregnancy on placental function and fetal hypothalamic-pituitary-adrenal function.$205,737
Funding Body: NHMRC (National Health & Medical Research Council)
Effect of severe asthma during pegnancy on placental function and the fetal hypothalamic pituitary adrenal axis.$45,000
Funding Body: Asthma Foundation of New South Wales
Glucocorticoid regulation of prostaglandin pathways involved in pre-term labour.$20,000
Funding Body: Hunter Medical Research Institute
1999 (4 grants)
Effect of Severe Asthma During Pregnancy on Placental Function and Fetal Outcome$50,000
Funding Body: Asthma Foundation of New South Wales
Corticotropin-releasing hormone effects on connexin expression and gap junction formation in human myometrium$10,193
Funding Body: Ramaciotti Foundations
Young Medical Researcher of the Year.$5,000
Funding Body: Hunter Medical Research Institute
Society of Gynecological Investigation Atlanta, Georgia, USA.$2,067
Funding Body: University of Newcastle
1998 (5 grants)
The Effect of Severe Asthma During Pregnancy on Placental Function and Fetal Outcome$130,000
Funding Body: Gladys M Brawn Memorial Fellowships
Effect of severe asthma during pregnancy on placental function and fetal outcome$90,000
Funding Body: Asthma Foundation of New South Wales
Effect of severe asthma during pregnancy on placental function and fetal outcome.$11,500
Funding Body: University of Newcastle
Travel to Dept of Physiology, Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada$5,000
Funding Body: Ramaciotti Foundations
Effect of CRH and oxytocin on connexin formation in the human myometrium in vitro$1,000
Funding Body: Ian Potter Foundation
EditResearch Supervision
| Number of current supervisions | 2 |
|---|
| Total current UoN PhD EFTSL | 0.3 |
|---|
For supervisions undertaken at an institution other that the University of Newcastle, details are shown in italics, and the institution name is listed below the program name.
Current Supervision
| Commenced | Proposed Completion | Program | Supervisor Type | Research Title |
|---|
| 2007 | 2015 | PhD (Paediatrics) | Co-Supervisor | Characteristics of Sex-specific Differences in Cardiovascular Adaptation in the First 2 Years of Life |
| 2006 | 2007 | Masters Epidemiology University of Newcastle | Principal Supervisor | Analysis of stillbirths from the john HUnter hospital Obstetric Database 1995-199 |
Past Supervision
| Year | Program | Supervisor Type | Research Title |
|---|
| 2012 | PhD (Reproductive Medicine) | Principal Supervisor | Effect of Maternal Asthma During Pregnancy on Aspects of Placental Immune Function |
| 2011 | PhD (Psychology - Science) | Co-Supervisor | Impact of Neonatal Infection on Adult Hippocampal Glucocorticoid and Mineralocorticoid Receptors and Hypothalamic-Pituitary-Adrenal Axis Outcomes |
| 2011 | PhD (Medicine) | Co-Supervisor | Human Endogenous Retroviruses and Immune Tolerance in Pregnancy |
| 2010 | PhD (Reproductive Medicine) | Co-Supervisor | Syncytin and Placental Exosomes: New Insights in Immunology of Pregnancy |
| 2009 | PhD (Medicine) | Principal Supervisor | Effect of Maternal Asthma During Pregnancy on Circulating Cytokines, Immune Cell Profile and Airway Inflammatory Mediator Release In-Vitro |
| 2008 | PhD (Medicine) | Principal Supervisor | The Influence of Sex-Specific Differences in Feto-Placental Glucocorticoid Metabolism on the Preterm Microvasculature and Transitional Circulation |
| 2005 | Honours Biol Sc Not Elsewhere Classifd University of Newcastle | Principal Supervisor | Glucocorticoid receptor expression in placentae of pregnancies complicated by asthma. |
| 2004 | Honours Biol Sc Not Elsewhere Classifd University of Newcastle | Principal Supervisor | Effect of inhaled glucocorticoids on 11 beta HSD2 activity in placentae of pregnancies complicated by asthma |
| 2004 | PhD (Medicine) | Principal Supervisor | The Effect of Maternal Asthma During Pregnancy on Placental Function and Fetal Development |
| 2003 | Honours Biol Sc Not Elsewhere Classifd University of Newcastle | Co-Supervisor | Effect of CRH on microvascular function during pregnancy |
| 2003 | Honours Biol Sc Not Elsewhere Classifd University of Newcastle | Principal Supervisor | Why are females more sensitive than males to inflammatory stimuli |
| 2002 | Honours Biol Sc Not Elsewhere Classifd University of Newcastle | Co-Supervisor | Placental metabolism of semi-synthetic glucocorticoids |
| 2001 | Honours Biochemistry & Cell Biology University of Newcastle | Principal Supervisor | Effect of CRH on microvascular function in human skin |
| 2001 | Honours Biol Sc Not Elsewhere Classifd University of Newcastle | Co-Supervisor | Prostaglandin production in human placenta and membranes |
| 2000 | Honours Biol Sc Not Elsewhere Classifd University of Newcastle | Principal Supervisor | Effect of inflammatory cytokines on myometrial connexins |