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Career Summary

Qualifications

  • PhD, University of Newcastle, 07/03/2003
  • Bachelor of Science (Honours), University of Newcastle, 01/05/1998

Research

Research keywords

  • allergy
  • asthma
  • mouse models
  • virus

Research expertise

I have established a mouse model of viral infection employing a rodent specific virus, which is the only such model in Australia. The model employs infection with a natural mouse pathogen, which induces natural virus-host interactions. I have developed this model in both neonatal and adult mice and have investigated the effects of respiratory viruses on whole mammal immune responses and predisposition/exacerbation of asthma. Briefly, a non-lethal PVM infection in adult mice induces pathologic features associated with viral associated asthma, namely a neutrophilic, mild eosinophilic influx into the lungs, expansion of CD8+ and CD4+ T cells, goblet cell hyperplasia, and airways hyper-responsiveness. Peak viral titre within the lungs occurs 6 days post infection (dpi), and precedes the peak inflammatory response which occurs 12 dpi and is characterised by CD8 T cell derived IFN-¿, neutrophils, monocytes, and mucus hyperplasia. As the inflammatory response resolves, cytokine production from polyclonally stimulated splenocytes switches from IFN-¿ to IL-13 (produced from CD4+ T cells). Interestingly, neonatal mice are not susceptible to a lethal PVM infection and are further protected from infection later in life. The immune response to re-infection is characterized by a lymphocytic and eosinophilic influx into the lungs, mucus cell hyperplasia, and a predominantly IFN-¿ response form CD8+ T cells despite the failure of the CD8+ T cells to expand upon re-infection. Recently we have also observed for the first time that angiogenesis (new blood vessel formation) occurs in the neonatal model of viral infection. Angiogenesis has also been widely associated with the development of asthma.

Fields of Research

CodeDescriptionPercentage
110700Immunology70
110200Cardiovascular Medicine And Haematology20
111700Public Health And Health Services10
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Highlighted Publications

For publications that are currently unpublished or in-press, details are shown in italics.

YearCitationAltmetricsLink
2006Siegle JS, Hansbro NG, Herbert C, Yang M, Foster PS, Kumar RK, 'Airway hyperreactivity in exacerbation of chronic asthma is independent of elosinophilic inflammation', American Journal of Respiratory Cell and Molecular Biology, 35 565-570 (2006) [C1]
2004Hansbro NG, Johansson ES, Au GG, Lindberg A, Barry RD, Shafren DR, 'Enterovirus capsid interactions with decay-accelerating factor mediate lytic cell infection', Journal of Virology, 78 1431-1439 (2004) [C1]
2004Hansbro NG, Beagley LG, Christiansen D, Loveland BE, Johansson ES, Beagley KW, et al., 'Novel role for decay-accelerating factor in Coxsackievirus A21-mediated cell infectivity', Journal of Virology, 78 12677-12682 (2004) [C1]

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (20 outputs)

YearCitationAltmetricsLink
2013Eftekhari P, Hajizadeh S, Reza Raoufy M, Reza Masjedi M, Yang M, Hansbro N, et al., 'Preventive effect of N-acetylcysteine in a mouse model of steroid resistant acute exacerbation of asthma', EXCLI Journal, 12 184-192 (2013) [C1]

Co-authors: Ming Yang, Paul Foster

2013Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, et al., 'A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis', The Journal of Allergy and Clinical Immunology, 131 752-762 (2013) [C1]
2013Collison A, Siegle JS, Hansbro NG, Kwok C-T, Herbert C, Mattes J, et al., 'Epigenetic changes associated with disease progression in a mouse model of childhood allergic asthma', DISEASE MODELS & MECHANISMS, 6 993-1000 (2013) [C1]
2013Herbert C, Siegle JS, Shadie AM, Nikolaysen S, Garthwaite L, Hansbro NG, et al., 'Development of asthmatic inflammation in mice following early-life exposure to ambient environmental particulates and chronic allergen challenge', DMM Disease Models and Mechanisms, 6 479-488 (2013) [C1]

Co-authors: Paul Foster

2011Siegle JS, Hansbro NG, Dong C, Angkasekwinai P, Foster PS, Kumar RK, 'Blocking induction of T helper type 2 responses prevents development of disease in a model of childhood asthma', Clinical and Experimental Immunology, 165 19-28 (2011) [C1]
2011Davidson SK, Kaiko GE, Loh Z, Lalwani A, Zhang V, Spann K, et al., 'Plasmacytoid Dendritic Cells promote host defense against Acute Pneumovirus infection via the TLR7-MyD88-Dependent signaling pathway', Journal of Immunology, 186 5938-5948 (2011) [C1]
2010Burgess JK, Boustany S, Moir LM, Weckmann M, Lau JY, Grafton K, et al., 'Reduction of tumstatin in asthmatic airways contributes to angiogenesis, inflammation, and hyperresponsiveness', American Journal of Respiratory and Critical Care Medicine, 181 106-115 (2010) [C1]
2010Lau JY, Oliver BG, Baraket M, Beckett EL, Hansbro NG, Moir LM, et al., 'Fibulin-1 Is increased in asthma - A novel mediator of airway remodeling?', Plos One, 5 1-13 (2010) [C1]
2010Siegle JS, Hansbro NG, Herbert C, Rosenberg HF, Domachowske JB, Asquith KL, et al., 'Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice', Respiratory Research, 11 1-15 (2010) [C1]
2009Phipps S, Hansbro NG, Lam CE, Foo A, Matthaei KI, Foster PS, 'Allergic sensitization is enhanced in early life through toll-like receptor 7 activation', Clinical and Experimental Allergy, 39 1920-1928 (2009) [C1]
2008Su Y-C, Rolph MS, Hansbro NG, Mackay CR, Sewell WA, 'Granulocyte-macrophage colony-stimulating factor is required for bronchial eosinophilia in a murine model of allergic airway inflammation', Journal of Immunology, 180 2600-2607 (2008) [C1]
2008Ito K, Herbert C, Siegle JS, Vuppusetty C, Hansbro NG, Thomas PS, et al., 'Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma', American Journal of Respiratory Cell and Molecular Biology, 39 543-550 (2008) [C1]
2008Hansbro NG, Horvat JC, Wark PA, Hansbro PM, 'Understanding the mechanisms of viral induced asthma: New therapeutic directions', Pharmacology & Therapeutics, 117 313-353 (2008) [C1]
2007Horvat JC, Beagley KW, Wade MA, Preston JA, Hansbro NG, Hickey DK, et al., 'Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease', American Journal of Respiratory and Critical Care Medicine, 176 556-564 (2007) [C1]
2007Weckmann M, Collison A, Simpson JL, Kopp MV, Wark PA, Smyth MJ, et al., 'Critical link between TRAIL and CCL20 for the activation of T(H)2 cells and the expression of allergic airway disease', Nature Medicine, 13 1308-1315 (2007) [C1]
2006Siegle JS, Hansbro NG, Herbert C, Yang M, Foster PS, Kumar RK, 'Airway hyperreactivity in exacerbation of chronic asthma is independent of elosinophilic inflammation', American Journal of Respiratory Cell and Molecular Biology, 35 565-570 (2006) [C1]
2004Shafren DR, Au GG, Nguyen T, Barry RD, Hansbro NG, Harvey ES, et al., 'Systemic therapy of malignant human melanoma tumors by a common cold-producing enterovirus, Coxsackievirus A21', Clinical Cancer Research, 10 53-60 (2004) [C1]
2004Hansbro NG, Johansson ES, Au GG, Lindberg A, Barry RD, Shafren DR, 'Enterovirus capsid interactions with decay-accelerating factor mediate lytic cell infection', Journal of Virology, 78 1431-1439 (2004) [C1]
2004Hansbro NG, Beagley LG, Christiansen D, Loveland BE, Johansson ES, Beagley KW, et al., 'Novel role for decay-accelerating factor in Coxsackievirus A21-mediated cell infectivity', Journal of Virology, 78 12677-12682 (2004) [C1]
2000Hansbro NG, Clulow J, Man SY, Jones RC, 'pH and bicarbonate in the ductuli efferentes testis of the rat', INTERNATIONAL JOURNAL OF ANDROLOGY, 23 46-50 (2000) [C1]

Co-authors: John Clulow

Show 17 more

Conference (22 outputs)

YearCitationAltmetricsLink
2013Hansbro P, Beckett E, Stevens R, Jarnicki A, Kim R, Hanish I, et al., 'A short-term model of COPD identifies a role for mast cell tryptase', JOURNAL OF IMMUNOLOGY, Honolulu, HI (2013) [E3]
2013Herbert C, Siegle JS, Shadie AM, Nikolaysen S, Garthwaite L, Hansbro NG, et al., 'EARLY LIFE EXPOSURE TO ENVIRONMENTAL PARTICULATES PREDISPOSES TO DEVELOPMENT OF ASTHMATIC INFLAMMATION', RESPIROLOGY (2013) [E3]
2010Siegle J, Hansbro NG, Dong C, Angkasekwinai P, Foster PS, Kumar R, 'Anti-Th2 cytokines inhibit progression in a murine model of childhood asthma', European Respiratory Society Annual Congress 2010. Abstracts, Barcelona, Spain (2010) [E3]

Co-authors: Paul Foster

2010Ptaschinski CM, Phipps S, Hansbro NG, Rosenberg HF, Mattes J, Foster PS, 'MicroRNAs are involved in the regulation of inflammatory responses characteristic of severe respiratory virus infection', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
2009Herbert C, Scruton K, Hsu K, Siegle JS, Hansbro NG, Foster PS, et al., 'Enhanced expression of cytokines by pulmonary T-cells and macrophages in a model of exacerbations of chronic asthma', American Journal of Respiratory and Critical Care Medicine, San Diego, CA (2009) [E3]

Co-authors: Paul Foster

2009Weckmann M, Lau J, Grafton K, Oliver B, Hansbro NG, Foster PS, et al., 'Tumstatin: A non-collagenous domain of collagen IV: Effects on inflammation and angiogenesis', Respirology, Darwin, NT (2009) [E3]
2009Schilter HC, Shum B, Shim D, Maslowski K, Tsai L, Kim R, et al., 'Fatty acid binding proteins: A link between metabolism and airway inflammation?', Respirology, Darwin, NT (2009) [E3]

Co-authors: Philip Hansbro

2009Siegle JS, Hansbro NG, Herbert C, Rosenberg HF, Asquith KL, Foster PS, Kumar RK, 'Interaction between early-life viral infection and allergen exposure induces an asthmatic phenotype in mice', Respirology, Darwin, NT (2009) [E3]
2008Hansbro NG, Boustany S, Oliver B, Burgess J, Black J, Rosenberg H, et al., 'Early life pneumoviral infection induces the development of pulmonary angiogenesis', Respirology, Melbourne, VIC (2008) [E3]
2008Schilter H, Shim D, Maslowski K, Tsai L, Shum B, Kim RY, et al., 'A role for fatty acid binding proteins in respiratory inflammation', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book, Canberra, ACT (2008) [E3]

Co-authors: Philip Hansbro

2008Boustany S, Oliver BG, Moir LM, Black JL, Hansbro PM, Hansbro NG, et al., 'Tumstatin, an angiogenic inhibitor, modulates airway angiogenesis', Respirology, Melbourne, VIC (2008) [E3]
2008Burgess JK, Boustany S, Oliver BG, Moir LM, Baraket M, Hansbro PM, et al., 'The absence of tumstatin in asthma may lead to angiogenesis and airway hyperresponsiveness', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
2007Horvat JC, Moller CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'Allergic airways disease (AAD) is differentially affected by chlamydial lung infection at different stages of life', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
2007Grissell TV, Hansbro NG, Hsu A, Mimica J, Wark PA, 'Response of primary bronchoepithelial cells from COPD, asthmatic and healthy subjects to infection with avian and human influenza virus strains', Respirology (Abstracts of the 12th Congress of the Asian Pacific Society of Respirology), Gold Coast, QLD (2007) [E3]

Co-authors: Peter Wark

2007Hansbro NG, Boustany S, Oliver BG, Burgess JK, Black JL, Hansbro PM, Foster PS, 'Viral-induced angiogenesis', Immuno 2007: 13th International Congress of Immunology. Abstracts and Posters, Rio de Janeiro, Brazil (2007) [E3]
2007Horvat JC, Garside CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'Development of allergic airways disease is differentially affected by chlamydial respiratory infection at different ages', American Journal of Respiratory and Critical Care Medicine, San Francisco, Calif. (2007) [E3]
2006Horvat JC, Moller CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'The development of allergic airways disease (AAD) is differently affected by chlamydial lung infection at different stages of life', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
2006Horvat JC, Wade MA, Preston JA, Hansbro NG, Gibson PG, Beagley KW, et al., 'Neonatal chlamydial infection exacerbates allergic airways disease', Abstracts ATS 2006 International Conference, San Diego, California (2006) [E3]
2006Kaiko GE, Phipps S, Lam CE, Hickey DK, Hansbro NG, Foster PS, Beagley KW, 'The chlamydia infection of dendritic cells drives the development of a pro-asthmatic response', Immunology and Cell Biology, Auckland, NZ (2006) [E3]

Co-authors: Paul Foster

2006Horvat JC, Wade MA, Preston JA, Hansbro NG, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease (AAD)', Respirology, Canberra (2006) [E3]
2005Horvat JC, Preston JA, Hansbro NG, Ferguson AL, Gibson PG, Beagley KW, et al., 'Neonatal chlamydial infection inhibits the development of allergic airway inflammation in adult mice', Inflammation Research, Melbourne, Australia (2005) [E3]
2003Jones RC, Knee RA, Ecroyd HW, Hansbro NG, Clulow J, Aitken RJ, Beagley KW, 'Delivery of Antibodies for Male Immunocontraception', The Third International Conference on the Epididymis, Charlottesville, Virginia (2003) [E3]
Show 19 more
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Grants and Funding

Summary

Number of grants8
Total funding$251,850

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2013 (1 grants)

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020132013
GNo:G1201186

2012 (1 grants)

SpectraMax M5e Multi-Mode Microplate Reader$50,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Linda Howland, Doctor Kelly Asquith
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$50,00020122012
GNo:G1100975

2011 (1 grants)

SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Phil Hansbro, Professor Paul Foster, Professor Joerg Mattes, Doctor Simon Keely, Doctor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$45,00020112011
GNo:G1100037

2010 (1 grants)

Buxco FinePointe software and FinePointe RC system for mice $39,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Nicole Hansbro, Doctor Simon Phipps, Doctor Ming Yang, Doctor Kelly Asquith, Doctor Catherine Ptaschinski, Professor Rakesh Kumar, Professor Judith Black
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$39,00020102010
GNo:G1000053

2009 (1 grants)

Coulter counter$41,150
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Simon Phipps, Doctor Ming Yang, Doctor Nicole Hansbro, Doctor Kelly Asquith
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$41,15020092009
GNo:G0189851

2008 (1 grants)

Individually ventilated cages (IVC) and associated ventilator, holding boxes and water bottles$35,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Simon Phipps, Doctor Ming Yang, Doctor Nicole Hansbro, Doctor Kelly Asquith
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$35,00020082008
GNo:G0188541

2007 (2 grants)

The role of tumstatin in angiogenesis and asthma$20,000
Funding Body: Hunter Medical Research Institute

Project Team
Professor Paul Foster, Doctor Nicole Hansbro, Doctor Simon Phipps, Professor Phil Hansbro
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020072007
GNo:G0187238

The 13th International COngress of Immunology, Rio de Janeoro, Brazil, 21/8/2007 - 25/8/2007$1,700
Funding Body: University of Newcastle

Project Team
Doctor Nicole Hansbro
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,70020072007
GNo:G0188062
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Research Supervision

Number of current supervisions0

No Supervisions.

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Dr Nicole Hansbro

Work Phone(02) 40420164
Fax(02) 40420024
Email
PositionPostdoctoral Research Fellow
Asthma, Allergy and Inflammation Research Centre
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaImmunology and Microbiology
Office
HMRI 2403,
Hunter Medical Research Institute,
Hunter Medical Research Institute
URL:www.newcastle.edu.au/profile/nicole-hansbro