Staff Profile
Dr Nicole Hansbro
Postdoctoral Research Fellow
School of Biomedical Sciences and Pharmacy
EditCareer Summary
Qualifications
- PhD, University of Newcastle, 07/03/2003
- Bachelor of Science (Honours), University of Newcastle, 01/05/1998
Research
Research keywords
- allergy
- asthma
- mouse models
- virus
Research expertise
I have established a mouse model of viral infection employing a rodent specific virus, which is the only such model in Australia. The model employs infection with a natural mouse pathogen, which induces natural virus-host interactions. I have developed this model in both neonatal and adult mice and have investigated the effects of respiratory viruses on whole mammal immune responses and predisposition/exacerbation of asthma. Briefly, a non-lethal PVM infection in adult mice induces pathologic features associated with viral associated asthma, namely a neutrophilic, mild eosinophilic influx into the lungs, expansion of CD8+ and CD4+ T cells, goblet cell hyperplasia, and airways hyper-responsiveness. Peak viral titre within the lungs occurs 6 days post infection (dpi), and precedes the peak inflammatory response which occurs 12 dpi and is characterised by CD8 T cell derived IFN-¿, neutrophils, monocytes, and mucus hyperplasia. As the inflammatory response resolves, cytokine production from polyclonally stimulated splenocytes switches from IFN-¿ to IL-13 (produced from CD4+ T cells). Interestingly, neonatal mice are not susceptible to a lethal PVM infection and are further protected from infection later in life. The immune response to re-infection is characterized by a lymphocytic and eosinophilic influx into the lungs, mucus cell hyperplasia, and a predominantly IFN-¿ response form CD8+ T cells despite the failure of the CD8+ T cells to expand upon re-infection. Recently we have also observed for the first time that angiogenesis (new blood vessel formation) occurs in the neonatal model of viral infection. Angiogenesis has also been widely associated with the development of asthma.
Fields of Research
| Code | Description | Percentage |
|---|
| 110700 | Immunology | 70 |
| 110200 | Cardiovascular Medicine And Haematology | 20 |
| 111700 | Public Health And Health Services | 10 |
EditPublications
No publications.
EditGrants and Funding
Summary
| Number of grants | 8 |
|---|
| Total funding | $251,850 |
|---|
For project grants received where the lead institution is other than the University of Newcastle, details are shown in italics.
- Indicates that the researcher may be seeking students for this project.
Click on a grant title below to expand the full details for that specific grant.
2013 (1 grants)
DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team |
|---|
| Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Mr Andrew Jarnicki, Doctor Michael Fricker |
| Scheme | Role |
|---|
| Equipment Grant | Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $20,000 | 2013 | 2013 |
| GNo:G1201186 |
2012 (1 grants)
SpectraMax M5e Multi-Mode Microplate Reader$50,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team |
|---|
| Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Jay Horvat, Doctor Simon Keely, Mr Andrew Jarnicki, Doctor Linda Howland, Doctor Kelly Asquith |
| Scheme | Role |
|---|
| Equipment Grant | Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $50,000 | 2012 | 2012 |
| GNo:G1100975 |
2011 (1 grants)
SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team |
|---|
| Professor Phil Hansbro, Professor Paul Foster, Professor Joerg Mattes, Doctor Simon Keely, Doctor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Associate Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog |
| Scheme | Role |
|---|
| Equipment Grant | Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $45,000 | 2011 | 2011 |
| GNo:G1100037 |
2010 (1 grants)
Buxco FinePointe software and FinePointe RC system for mice
$39,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team |
|---|
| Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Nicole Hansbro, Doctor Simon Phipps, Doctor Ming Yang, Doctor Kelly Asquith, Doctor Catherine Ptaschinski, Professor Rakesh Kumar, Professor Judith Black |
| Scheme | Role |
|---|
| Equipment Grant | Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $39,000 | 2010 | 2010 |
| GNo:G1000053 |
2009 (1 grants)
Coulter counter$41,150
Funding Body: NHMRC (National Health & Medical Research Council)
2008 (1 grants)
Individually ventilated cages (IVC) and associated ventilator, holding boxes and water bottles$35,000
Funding Body: NHMRC (National Health & Medical Research Council)
2007 (2 grants)
The role of tumstatin in angiogenesis and asthma$20,000
Funding Body: Hunter Medical Research Institute
The 13th International COngress of Immunology, Rio de Janeoro, Brazil, 21/8/2007 - 25/8/2007$1,700
Funding Body: University of Newcastle
| Project Team |
|---|
| Doctor Nicole Hansbro |
| Scheme | Role |
|---|
| Travel Grant | Chief Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $1,700 | 2007 | 2007 |
| GNo:G0188062 |
EditResearch Supervision
| Number of current supervisions | 0 |
|---|
No Supervisions.
