Staff Profile

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Career Summary

Qualifications

  • PhD, University of Newcastle, 30/04/2009
  • Bachelor of Science (Biotechnology)(Honours), University of Newcastle, 16/12/2004
  • Bachelor of Science (Biotechnology), University of Newcastle, 11/12/2003

Research

Research keywords

  • Cancer Genetics
  • Endometrial Cancer
  • Gene Expression Profiling
  • HNPCC
  • Melanoma
  • Mutations
  • Polymorphisms
  • Skin Cancer
  • UV-light Radiation

Research expertise

Molecular genetics and pathology of cancer.

Languages

  • English

Fields of Research

CodeDescriptionPercentage
111200Oncology And Carcinogenesis100

Memberships

Committee/Associations (relevant to research).

  • Member - American Association for Cancer Research
  • Member - Australian Society for Medical Research
  • Member - Australasian Microarray and Associated Technologies Association
  • Member - Human Genetics Society of Australasia
  • Hunter Medical Research Institute Cancer Research Program Seminar Day Coordinator

Awards

Distinction.

2003Faculty of Science and Information Technology Commendation List for Outstanding Achievement
University of Newcastle (Australia)
Placement on Faculty of Science and Information Technology Commendation List for Outstanding Achievement.

Research Award.

2010HMRI PULSE Education Prize
Hunter Medical Research Institute (Australia)
Attendance at 101st American Association for Cancer Research (AACR) Annual Meeting, Washington, DC, USA
2008HMRI Bogner Cancer Research Fellow
Hunter Medical Research Institute (Australia)
Postdoctoral Research Fellowship
2006HMRI Jennie Thomas Special Competitive Research Fund for Early Career Researchers in Cancer
Hunter Medical Research Institute (Australia)
Support for a PhD student to undertake part of their thesis work in a collaborating laboratory/institute outside of Newcastle. The research was performed for 6 months at the German Cancer Research Center (DKFZ), Heidelberg, Germany under the supervision of Professor Ute Hamann.
2005Australian Postgraduate Award
University of Newcastle (Australia)
Support for PhD studies

Collaboration

The molecular mechanisms of UV-light induced skin cancers

Base excision repair in melanoma

Nucleotide excision repair in melanoma

Genetic variation and endometrial cancer risk

Administrative

Administrative expertise

2009 - HMRI New Building Lab Coordinator

I represented the Information-Based Medicine group at the HMRI new building meetings for the design of the laboratory space.

2009 - Mentor/Mentee Program

This program was introduced at the beginning of 2009 to improve mentoring within the School of Biomedical Sciences and Pharmacy, University of Newcastle, Australia. I was involved as a mentee within this program and was assigned a mentor who was a senior researcher within the school.

2008 - Interviewed by the Newcastle Herald

"Out of School" Success Story

The title of the article was "Cancer Crusader" which outlined my development into a successful cancer researcher in the Hunter Region.

Teaching

Teaching keywords

  • Bioinformatics
  • Genetics

Teaching expertise

Student Supervision

  • University of Newcastle, Australia

Bachelor of Biotechnology (1 Student)

Research Assistant

July 2008 - current

  • University of Newcastle, Australia

Bachelor of Biomedical Sciences (2 Students)

Work Experience and Student Placement (HUBS3409)

December 2008 - February 2009 and July 2009 - November 2009

  • University of Tromsø, Norway

Master of Pharmacy (2 Exchange Students)

6 month research project to complete their studies

November 2008 - May 2009

Casual Academic

  • Computer Lab Tutor

§ HUBS2409

Introduction to Online Databases

July 2008

§ HUBS1202

Human Genomics

September 2009 - November 2009

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Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (19 outputs)

YearCitationAltmetricsLink
2014Ashton KA, Scurry J, Ouveysi A, Ebbs J, Jaaback K, Bowden NA, 'Transformation of endometrioid carcinoma to carcinoma with trophoblastic differentiation: clinicopathological and whole genomic study.', Pathology, 46 351-353 (2014)
2013Talseth-Palmer B, Wijnen JT, Brenne IS, Jagmohan-Changur S, Barker DJ, Ashton KA, et al., 'Combined analysis of three Lynch syndrome cohorts confirms the modifying effects of 8q23.3 and 11q23.1 in MLH1 mutation carriers', International Journal of Cancer, 132 1487-1729 (2013) [C1]
2013Bowden NA, Ashton KA, Vilain RE, Avery-Kiejda KA, Davey RJ, Murray HC, et al., 'Regulators of Global Genome Repair Do Not Respond to DNA Damaging Therapy but Correlate with Survival in Melanoma', PLOS ONE, 8 (2013) [C1]
2012Ashton KA, Scurry JP, Rutherford J, Otton GR, Scott R, Bowden NA, 'Nodular prurigo of the vulva', Pathology, 44 565-567 (2012) [C3]
2011Kiejda KA, Bowden NA, Croft AJ, Scurr LL, Kairupan CF, Ashton KA, et al., 'P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation', BMC Cancer, 11 203-219 (2011) [C1]
2011Australian Ntl Endometrial Cancer Study Group, Scott R, Ashton KA, Proietto AM, Otton GR, Ntl Study Of Endometrical Cancer Genetics Group, 'Genome-wide association study identifies a common variant associated with risk of endometrial cancer', Nature Genetics, 43 451-455 (2011) [C1]
2011Talseth-Palmer B, Brenne IS, Ashton KA, Evans T-J, McPhillips M, Groombridge C, et al., 'Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in lynch syndrome', Journal of Medical Genetics, 48 279-284 (2011) [C1]
2010Bowden NA, Ashton KA, Kiejda KA, Zhang XD, Hersey P, Scott R, 'Nucleotide excision repair gene expression after cisplatin treatment in melanoma', Cancer Research, 70 7918-7926 (2010) [C1]
2010Ashton KA, Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, Scott R, 'Toll-Like Receptor (TLR) and Nucleosome-binding Oligomerization Domain (NOD) gene polymorphisms and endometrial cancer risk', BMC Cancer, 10 1-7 (2010) [C1]
2010Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, Gilbert M, et al., 'Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk', Cancer Epidemiology, 34 328-337 (2010) [C1]
2009Ashton KA, Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, et al., 'Polymorphisms in TP53 and MDM2 combined are associated with high grade endometrial cancer', Gynecologic Oncology, 113 109-114 (2009) [C1]
2009Ashton KA, Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, et al., 'Estrogen receptor polymorphisms and the risk of endometrial cancer', BJOG: An International Journal of Obstetrics and Gynaecology, 116 1053-1061 (2009) [C1]
2009Ashton KA, Proietto AM, Otton GR, Symonds IM, Scott R, 'Genetic variants in MUTYH are not associated with endometrial cancer risk', Hereditary Cancer in Clinical Practice, 7 1-5 (2009) [C1]
2008Ashton KA, Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, et al., 'The influence of the Cyclin D1 870 G>A polymorphism as an endometrial cancer risk factor', BMC Cancer, 8 1-6 (2008) [C1]
2008Talseth-Palmer B, Ashton KA, Meldrum C, Suchy J, Kurzawski G, Lubinski J, Scott R, 'Aurora-A and Cyclin D1 polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer', International Journal of Cancer, 122 1273-1277 (2008) [C1]
2008Dunning AM, Pooley KA, Chang-Claude J, Easton DF, Peto J, Houlston R, et al., 'Association of a common AKAP9 variant with breast cancer risk: A collaborative analysis', Journal of the National Cancer Institute, 100 437-442 (2008) [C1]
2006Ashton KA, Meldrum CJ, McPhillips ML, Suchy J, Kurzawski G, Lubinski J, Scott R, 'The association of the COMT V158M polymorphism with endometrial/ovarian cancer in HNPCC families adhering to the Amsterdam criteria', Hereditary Cancer in Clinical Practice, 4 94-102 (2006) [C1]
2005Ashton KA, Meldrum CJ, McPhillips ML, Kairupan CF, Scott R, 'Frequency of the common MYH mutations (G382D and Y165C) in MMR mutation positive and negative HNPCC patients', Hereditary Cancer in Clinical Practice, 3 65-70 (2005) [C1]
2004Scott R, Ashton KA, 'Familial breast and bowel cancer: Does it exist?', Hereditary Cancer in Clinical Practice, 2 25-59 (2004) [C1]
Show 16 more

Conference (21 outputs)

YearCitationAltmetricsLink
2013Talseth-Palmer B, Meldrum C, Ashton KA, Spigelman A, Scott RJ, 'Revealing cancer complexity - Identification of Lynch syndrome cases', Familial Cancer, Carins, QLD (2013) [E3]
2012Talseth-Palmer B, Wijen J, Brenne I, Jagomohan-Changur S, Baker D, Ashton KA, et al., 'Colorectal cancer risk modification in Lynch syndrome', Human Genome Meeting 2012: Genetics and Genomics in Personalised Medicine. Abstract Book, Sydney, NSW (2012) [E3]
2011Talseth-Palmer B, Wijnen JT, Brenne IS, Jagmohan-Changur S, Ashton KA, Tops CM, et al., 'Chromosome 8q23.3, 10p14 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome - a combined analysis of the Australian, Dutch and Polish Lynch syndrome cohorts', Familial Aspects of Cancer: Research and Practice 2011, Kingscliff, NSW (2011) [E3]
2011Bowden NA, Ashton KA, Kiejda KA, Zhang XD, Hersey P, Scott R, 'Downstream effects of reduction in nucleotide excision repair in response to cisplatin treatment in melanoma', Pigment Cell & Melanoma Research, Tampa, FL (2011) [E3]
2011Talseth-Palmer B, Wijnen JT, Brenne IS, Jagmohan-Changur S, Ashton KA, Tops CM, et al., 'Chromosome 8q23.3 AND 11q23.1 variants modify colorectal cancer risk in Lynch syndrome: A meta-analysis of the Dutch and Australian Lynch syndrome cohorts', Abstracts: 4th Biennial Meeting: International Society for Gastrointestinal Hereditary Tumours, San Antonio, TX (2011) [E3]
2010Vilain RE, Ashton KA, Bowden NA, Braye SG, Ashman LK, Scott RJ, 'Clinicopathological and gene expression profiling of advanced melanoma harbouring KIT and common kinase mutations', Melanoma 2010 Congress. Oral and Poster Abstracts, Sydney, NSW (2010) [E3]
2010Evans T-J, Talseth-Palmer B, Brenne IS, Ashton KA, McPhillips M, Groombridge C, et al., 'Colorectal cancer suspectibility loci on chr 8q23.3 and 11q23.1 as modifiers for disease expression in Lynch syndrome', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
2010Ashton KA, Bowden NA, Kairupan CF, Kiejda KA, Zhang XD, Hersey P, Scott R, 'Base excision repair and gene expression profiling in malignant melanoma', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
2010Bowden NA, Ashton KA, Kiejda KA, Vilain RE, Braye SG, Kairupan CF, et al., 'Nucleotide excision repair gene expression in melanoma', Melanoma 2010 Congress. Oral and Poster Abstracts, Sydney, NSW (2010) [E3]
2010Ashton KA, Bowden NA, Vilain RE, Kairupan CF, Kiejda KA, Zhang XD, et al., 'Genetic variation of the base excision repair gene, MUTYH, and melanoma development', Melanoma 2010 Congress. Oral and Poster Abstracts, Sydney, NSW (2010) [E3]
2010Bowden NA, Ashton KA, Kiejda KA, Zhang XD, Hersey P, Scott R, 'Altered nucleotide excision repair gene expression after cisplatin treatment in melanoma', AACR 101st Annual Meeting 2010. Abstracts, Washington, DC (2010) [E3]
2009Kairupan CF, Bowden NA, Ashton KA, Zhang XD, Hersey P, Scott R, 'Gene expression profiling in malignant melanoma', AMATA 2009, Katoomba, NSW (2009) [E3]
2009Bowden NA, Ashton KA, Stibbard GJ, Cox MB, Baines KJ, Scott R, 'Predicting xeroderma pigmentosum complementation group by gene expression profiling', AMATA 2009, Katoomba, NSW (2009) [E3]
2008Ashton KA, Proietto AM, Otton GR, Hamann U, Scott R, 'The genetic basis of endometrial cancer', Conference on Translational Cancer Research: Abstracts, Newcastle, NSW (2008) [E3]

Co-authors: Rodney Scott

2008Bowden NA, Ashton KA, Kiejda KA, Zhang XD, Hersey P, Scott R, 'Altered nucleotide excision repair gene expression after cisplatin treatment in melanoma', Proceedings of the Australian Health and Medical Research Congress 2008, Brisbane, QLD (2008) [E3]
2008Bowden NA, Ashton KA, Baines KJ, Cox MB, Scott R, 'Altered gene expression after UV-light induced DNA damage', Conference on Translational Cancer Research: Abstracts, Newcastle, NSW (2008) [E3]
2008Ashton KA, Proietto AM, Otton GR, Hamann U, Scott R, 'The genetic basis of endometrial cancer', Keystone Symposia on Molecular and Cellular Biology: Abstract Book, Singapore (2008) [E3]

Co-authors: Rodney Scott

2008Ashton KA, Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, et al., 'Combined tp53 r72p and mdm2 snp309 genotypes are associated with high grade endometrial cancer', ASMR XVII NSW Scientific Meeting: Programme and Abstracts, Sydney, NSW (2008) [E3]
2006Ashton KA, Meldrum CJ, McPhillips ML, Suchy J, Kurzawski G, Lubinski J, Scott R, 'Are polymorphisms in the toll-like receptors associated with disease risk in HNPCC?', 11th International Human Genetics: Final Program, Brisbane, QLD (2006) [E3]

Co-authors: Rodney Scott

2005Ashton KA, Talseth-Palmer B, Meldrum CJ, McPhillips ML, Scott R, 'COMT polymorphism (V158M) and its association with endometrial cancer in HNPCC families that adhere to the Amsterdam or Bethesda criteria', Human Genetics Society of Australasia 29th Annual Conference, Newcastle, NSW (2005) [E3]
2005Talseth-Palmer B, Meldrum C, Ashton KA, Scott R, 'Age of disease onset in HNPCC patients is more complex than that predicted by R72P polymorphism in TP53', Human Genetics Society of Australasia 29th Annual Conference, Newcastle, NSW (2005) [E3]
Show 18 more
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Grants and Funding

Summary

Number of grants5
Total funding$189,000

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2011 (2 grants)

A molecular genetic investigation of MUTYH in melanoma progression$90,000
Funding Body: Cure Cancer Australia Foundation

Project Team
Doctor Katie Ashton
SchemeRole
Postdoctoral FellowshipChief Investigator
Total AmountFunding StartFunding Finish
$90,00020112011
GNo:G1000855

Nucleotide excision repair gene expression in melanoma$35,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Nikola Bowden, Doctor Katie Ashton, Doctor Stephen Braye, Professor Rodney Scott, Dr Ricardo Vilain
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$35,00020112011
GNo:G1001057

2010 (1 grants)

Pulse - Education Prize$4,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Katie Ashton
SchemeRole
PULSE Education PrizeChief Investigator
Total AmountFunding StartFunding Finish
$4,00020102010
GNo:G0900131

2009 (1 grants)

Gene expression profiling of Xeroderma pigmentosum$45,000
Funding Body: Hunter Medical Research Institute

Project Team
Professor Rodney Scott, Doctor Nikola Bowden, Doctor Katie Ashton
SchemeRole
Postdoctoral FellowshipInvestigator
Total AmountFunding StartFunding Finish
$45,00020092010
GNo:G0900194

2006 (1 grants)

Genetic susceptibility in Endometrial Cancer$15,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Katie Ashton, Professor Rodney Scott
SchemeRole
Special Competitive Research Fund for Early Career Researchers in CancerChief Investigator
Total AmountFunding StartFunding Finish
$15,00020062006
GNo:G0186110
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Research Supervision

Number of current supervisions0

No Supervisions.

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Dr Katie Ashton

Work Phone(02) 40420282
Fax(02) 40420031
Email
PositionSenior Research Assistant
Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaMedical Genetics
Office
HMRI Level 3 West,
Hunter Medical Research Institute,
John Hunter Hospital
URL:www.newcastle.edu.au/profile/katie-ashton