Professor Alistair Sim

Conjoint Professor

School of Biomedical Sciences and Pharmacy (Medical Biochemistry)

Career Summary

Biography

Since my seminal work in characterising the first ever pharmacological inhibitor of protein phosphatases, I have continued to build an international and national reputation for my work that seeks to understand the ways in which these enzymes regulate cellular signalling and disease. I have made key findings in the way in which protein phosphatases respond to physiological and environmental signals and in the role these enzymes play in neurotransmission and in the initiation of asthma.

My publications have now received over 2000 citations and I am ranked in the top 15% of my field internationally. In recognition of this standing in my field I have received annual invitations to speak at key symposia at major international and national conferences. I have also established a number of mutually beneficial international collaborations in the USA and UK.

I am one of only 4 Australian researchers on the Editorial Board of The Biochemical Journal, Europes leading scientific journal for biochemistry and I sit on the Biochemistry Grant Review Panel for the National Health and Medical Research Council Australias leading medical research funding body. I have attracted funding from the Wellcome Foundation, UK to establish proteomics facilities and I am a project director of the Australian Cooperative Research Centre for Asthma and Airways new diagnostics proteomics discovery program.

I hold an international patent for anticancer therapeutics and current asthma diagnostic work is under intellectual property protection procedures.

Research Expertise
Since joining the university in 1989, I have provided national focus and international leadership in cellular signalling with a focus on the regulatory enzymes, protein phosphatases. Current focus is investigation of these key cell regulatory enzymes in the etiology and management of national priority diseases such as asthma and cancer, but also maternal health. I employ a broad range of modern molecular and cellular techniques with a major focus on proteomics for identification of molecular markers of disease

Teaching Expertise
My main teaching focus is into the medical program and the bachelor of biomedical sciences. Key expertise is in the area of cellular signaling and metabolism.

Administrative Expertise
I have occupied a broad range of senior administrative positions within my school, faculty and university.


Qualifications

  • PhD, Australian National University
  • Bachelor of Science (Honours), Aberdeen University

Keywords

  • Biochemistry
  • Cell signalling
  • Medical Biochemistry
  • asthma
  • cancer
  • cell biology
  • cell signalling
  • exocytosis
  • metabolism
  • protein kinase
  • protein phosphatase
  • protein phosphorylation
  • protein targeting
  • proteomics

Fields of Research

CodeDescriptionPercentage
060199Biochemistry and Cell Biology not elsewhere classified35
110199Medical Biochemistry and Metabolomics not elsewhere classified50
110999Neurosciences not elsewhere classified15

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/07/2007 - 31/12/2007ProfessorUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

DatesTitleOrganisation / Department
1/01/2004 - 1/06/2006Assistant Dean ResearchUniversity of Newcastle
Faculty Of Health
Australia
1/01/2002 - Associate Professor of Medical BiochemistryUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/1998 - 1/12/2001Senior Lecturer in Medical BiochemistryUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/1992 - 1/12/1997Lecturer in Medical BiochemistryUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/1990 - 1/12/1991Research FellowUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/09/1985 - 1/12/1989Research Fellow
Biochemistry
University of Dundee, Scotland
School of Life Sciences
United Kingdom

Membership

DatesTitleOrganisation / Department
Member - The Biochemical JournalThe Biochemical Journal
Australia
Grant Review Panel Member - NHMRCNHMRC Committee
Australia

Awards

Recognition

YearAward
2007Protein Phosphatase Research Portal
Unknown

Invitations

Participant

YearTitle / Rationale
2006), The Australian Physiology and Pharmacology Society Annual Meeting
Organisation: ), The Australian Physiology and Pharmacology Society Description: This meeting is the premier Australian conference in physiology and pharmacology. I was an invited symposium speaker
2006Australian Neuroscience Society Meeting
Organisation: Australian Neuroscience Society Description: This meeting is the premier Neuroscience meeting in Australia. I was an invited symposium speaker.
2005Combio
Organisation: Australian Society for Biochemistry and Molecular Biology Description: Combio is Australia's premier Biochemistry meeeting. I was an invited symposium speaker
2005FEBS Europhosphatase
Organisation: Federation of European Biochemical Societies Description: The FEBS Europhosphatase meeting is the premier international meeting in my field. All speakers are invited by the organising committee
2003FEBS Europhosphatase Meeting
Organisation: Federation of European Biochemical Societies Description: The FEBS Europhosphatase meeting is the premier international meeting in my field. All speakers are invited by the organising committee
2002FASEB Summery Research Conference on Protein Phosphatases
Organisation: Federation of American Society for Experimental Biology Description: The FASEB Summer Research Conference is the major biennial international conference in my field. All speakers are invited by the organising committee
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (26 outputs)

YearCitationAltmetricsLink
2013Mate K, Sim A, Weidenhofer J, Milward L, Scott J, 'Investigation of the human disease osteogenesis imperfecta: A research-based introduction to concepts and skills in biomolecular analysis', Biochemistry & Molecular Biology Education, 41 103-109 (2013) [C1]
DOI10.1002/bmb.20672Author URL
CitationsScopus - 1
Co-authorsKaren Mate, Liz Milward, Judith Weidenhofer
2011Verrills NM, Irwin JA, He XY, Wood LG, Powell H, Simpson JL, et al., 'Identification of novel diagnostic biomarkers for asthma and chronic obstructive pulmonary disease', American Journal of Respiratory and Critical Care Medicine, 183 1633-1643 (2011) [C1]
DOI10.1164/rccm.201010-1623OC
CitationsScopus - 36Web of Science - 34
Co-authorsVanessa Mcdonald, Lisa Wood, Peter Gibson, Nikki Verrills, Jodie Simpson
2010Roberts KG, Smith AM, McDougall FK, Carpenter HC, Horan MP, Neviani P, et al., 'Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers', Cancer Research, 70 5438-5447 (2010) [C1]
DOI10.1158/0008-5472.CAN-09-2544
CitationsScopus - 56Web of Science - 52
Co-authorsNikki Verrills, Leonie Ashman
2010Kranias G, Watt L, Carpenter HC, Holst J, Ludowyke R, Strack S, et al., 'Protein phosphatase 2A carboxymethylation and regulatory B subunits differentially regulate mast cell degranulation', Cellular Signalling, 22 1882-1890 (2010) [C1]
DOI10.1016/j.cellsig.2010.07.017
CitationsScopus - 5Web of Science - 5
Co-authorsNikki Verrills
2006Sim AT, Ludowyke RI, Verrills NM, 'Mast cell function: Regulation of degranulation by serine/threonine phosphatases', Pharmacology & Therapeutics, 112 425-439 (2006) [C1]
DOI10.1016/j.pharmthera.2006.04.011
CitationsScopus - 17Web of Science - 16
Co-authorsNikki Verrills
2006Sim AT, Herd LM, Proctor DT, Baldwin ML, Meunier FA, Rostas JA, 'High throughput analysis of endogenous glutamate release using a fluorescence plate reader', Journal of Neuroscience Methods, 153 43-47 (2006) [C1]
DOI10.1016/j.jneumeth.2005.10.004
CitationsScopus - 2Web of Science - 2
Co-authorsLynn Herd, John Rostas
2006Baldwin ML, Cammarota MP, Sim AT, Rostas JA, 'Src family tyrosine kinases differentially modulate exocytosis from rat brain nerve terminals', Neurochemistry International, 49 80-86 (2006) [C1]
DOI10.1016/j.neuint.2006.01.002
CitationsScopus - 10Web of Science - 9
Co-authorsJohn Rostas
2006Migues PV, Lehmann IT, Fluechter L, Cammarota MP, Gurd JW, Sim AT, et al., 'Phosphorylation of CaMKII at Thr253 occurs in vivo and enhances binding to isolated postsynaptic densities', Journal of Neurochemistry, 98 289-299 (2006) [C1]
DOI10.1111/j.1471-4159.2006.03876.x
CitationsScopus - 24Web of Science - 22
Co-authorsPhil Dickson, John Rostas
2003Baldwin ML, Rostas JA, Sim AT, 'Two modes of excytosis from synaptosomes are differentially regulated by protein phosphatase types 2A and 2B', Journal of Neurochemistry, 85 1190-1199 (2003) [C1]
DOI10.1046/j.1471-4159.2003.01779.x
CitationsScopus - 26Web of Science - 25
Co-authorsJohn Rostas
2003Bevilaqua L, Cammarota MP, Dickson PW, Sim AT, Dunkley PR, 'Role of protein phosphatase 2C from bovine adrenal chromaffin cells in the dephosphorylation of phospho-serine 40 tyrosine hydroxylase', Journal of Neurochemistry, 85 1368-1373 (2003) [C1]
DOI10.1046/j.1471-4159.2003.01792.x
CitationsScopus - 18Web of Science - 18
Co-authorsPeter Dunkley, Phil Dickson
2003Sim AT, Baldwin ML, Rostas JA, Holst J, Ludowyke RI, 'The role of serine/threonine protein phosphatases in exocytosis', Biochemical Journal, 373 641-659 (2003) [C1]
DOI10.1042/BJ20030484
CitationsScopus - 37Web of Science - 36
Co-authorsJohn Rostas
2002McCluskey A, Sim A, Sakoff J, 'Serine-threonine protein phosphatase inhibitors: Development of potential therapeutic strategies', Journal of Medicinal Chemistry, 45 1151-1175 (2002) [C1]
CitationsScopus - 178Web of Science - 176
Co-authorsJennette Sakoff, Adam Mccluskey
2002Leal R, Sim AT, Goncalves C, Dunkley PR, 'Tyrosine Hydroxylase Dephosphorylation by Protein Phosphatase 2A in Bovine Adrenal Chromaffin Cells', Neurochemical Research, 27, No 3 207-213 (2002) [C1]
CitationsScopus - 23Web of Science - 23
Co-authorsPeter Dunkley
2002McCluskey A, Atherton MA, Walkom CC, Bowyer M, Sim A, Young D, Sakoff J, 'The first two cantharidin analogues displaying PP1 selectivity', Bioorganic & Medicinal Chemistry Letters, 12 391-393 (2002) [C1]
CitationsScopus - 39Web of Science - 38
Co-authorsMirella Atherton, Michael Bowyer, Jennette Sakoff, Adam Mccluskey
2002Sim AT, Ludowyke R, 'The Complex Nature of Protein Phosphatases', IUBMB Life, 53 283-286 (2002) [C1]
CitationsScopus - 12Web of Science - 9
2002Holst J, Sim AT, Ludowyke R, 'Protein Phosphatases 1 and 2A Transiently Associate with Myosin during the Peak Rate of Secretion from Mast Cells', Molecular Biology of the Cell, 13 1083-1098 (2002) [C1]
CitationsScopus - 27Web of Science - 26
2001Schillace R, Voltz J, Sim AT, Shenolikar S, Scott J, 'Multiple Interactions within the AKAP220 Signaling Complex Contribute to Protein Phosphatase 1 Regulation', Journal of Biological Chemistry, 276 No. 15 12128-12134 (2001) [C1]
CitationsScopus - 37Web of Science - 37
2001Michell B, Chen Z-P, Tiganis T, Stapleton D, Katsis F, Power D, et al., 'Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase', Journal of Biological Chemistry, 276 17625-17628 (2001) [C1]
CitationsScopus - 372Web of Science - 346
2001Sim AT, 'Protein Phosphatases: Regulating the Regulators', Australian Biochemist, 32 No. 1 13-15 (2001) [C1]
2000Ludowyke RI, Holst J, Mudge L-M, Sim AT, 'Transient Translocation and Activation of Protein Phosphatase 2A during Mast Cell Secretion', The Journal of Biological Chemistry, 275 No. 9 March 3 6144-6152 (2000) [C1]
CitationsScopus - 49Web of Science - 47
2000Lengyel I, Fieuw-Makaroff S, Hall AL, Sim AT, Rostas JA, Dunkley PR, 'Modulation of the Phosphorylation and Activity of Calcium/Calmodulin-Dependent Protein Kinase II by Zinc', Journal of Neurochemistry, 75 No. 2 594-605 (2000) [C1]
CitationsScopus - 51Web of Science - 51
Co-authorsJohn Rostas, Peter Dunkley
2000McCluskey A, Atherton MA, Mudgee L, Sim A, Sakoff JA, Quinn R, 'Anhydride modified cantharidin analogues. Is ring opening important in the inhibition of protein phosphatase 2A?', European Journal of Medicinal Chemistry, 35 957-964 (2000) [C1]
CitationsScopus - 41Web of Science - 38
Co-authorsAdam Mccluskey, Mirella Atherton, Jennette Sakoff
2000Bowyer MC, 'Anhydride Modified Cantharidin Analogues: Synthesis, Inhibition of Protein Phosphatases 1 and 2A and Anticancer Activity', Bioorganic & Medicinal Chemistry Letters, 10 1687-1690 (2000) [C1]
CitationsScopus - 69Web of Science - 69
Co-authorsAdam Mccluskey, Jennette Sakoff, Michael Bowyer
1999Sim AT, Scott J, 'Targeting of PKA, PKC and protein phosphatases to cellular microdomains', Cell Calcium, 26 No. 5 209-217 (1999) [C1]
CitationsWeb of Science - 65
1998Capon RJ, Rooney F, Murray LM, Collins E, Sim AT, Rostas JA, et al., 'Dragmacidins: New protein phosphatase inhibitors from a Southern Australian deep-water marine sponge Spongosorites sp', Journal of Natural Products, 61 660-662 (1998) [C1]
CitationsScopus - 111Web of Science - 102
Co-authorsJohn Rostas
1998Sim AT, Collins E, Mudge LM, Rostas JA, 'Developmental regulation of protein phosphatase types 1 and 2A in post-hatch chicken brain', Neurochemical Research, 23(4) 487-491 (1998) [C1]
CitationsWeb of Science - 11
Co-authorsJohn Rostas
Show 23 more journal articles

Review (1 outputs)

YearCitationAltmetricsLink
2003Sim AT, Holst J, Ludowyke RI, 'Protein Phosphatase Translocation in RBL-2H3 Cells', Methods in Enzymology (2003) [D1]

Conference (10 outputs)

YearCitationAltmetricsLink
2010Verrills NM, Roberts KG, Smith AM, McDougall FK, Carpenter HC, Neviani P, et al., 'Targeting the tumour suppressor, PP2A, as a novel therapy for acute myeloid leukaemia', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
Co-authorsNikki Verrills, Leonie Ashman
2009Kranias G, Cottrell LF, Carpenter HC, Sim AT, Verrills NM, 'Protein phosphatase 2A carboxymethylation and regulatory B subunits differentially regulate mast cell degranulation', FEBS Journal, Prague, Czech Republic (2009) [E3]
Co-authorsNikki Verrills
2009Skelding KA, Liao X, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Functional consequences of CaMKII phosphorylation at THR253 in neurons', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authorsKathryn Skelding, John Rostas, Nikki Verrills, Phil Dickson
2008Skelding KA, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Identification of CaMKII binding proteins in brain sensitive to CaMKII phosphorylation state', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authorsKathryn Skelding, John Rostas, Nikki Verrills, Phil Dickson
2008Skelding KA, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Development of a novel method for the identification of CaMKII binding proteins', Journal of Neurochemistry, Shanghai, China (2008) [E3]
Co-authorsPhil Dickson, Nikki Verrills, John Rostas, Kathryn Skelding
2007Roberts KG, Ashman LK, Sim AT, Verrills NM, 'Regulation of protein phosphatase 2A (PP2A) B subunits by Bcr/Abl: Potential targets for chronic myeloid leukemia', AACR Meeting Abstracts Online (Abstracts of the 98th AACR Annual Meeting), Los Angeles (2007) [E3]
Co-authorsNikki Verrills, Leonie Ashman
2006Rostas JA, Migues PV, Fluechter L, Dickson PW, Sim AT, Rawoff S, et al., 'Phosphorylation of CAMKII at T253 induced by transient global ischaemia', Proceedings of the Australian Neuroscience Society, Sydney (2006) [E3]
Co-authorsJohn Rostas, Phil Dickson
2006Verrills NM, Carpenter HC, Sim AT, 'Disruption of Actin-containing Protein Phosphatase 2A Complexes Regulates Cell Motility in Neuroblastoma Cells', Molecular & Cellular Proteomics, California, USA (2006) [E3]
Co-authorsNikki Verrills
2004Rostas JA, Baldwin ML, Cammarota MP, Sim AT, 'The regulation of synaptosomal exocytosis by Src tyrosine kinases', Journal of Neurochemistry, Hong Kong (2004) [E3]
Co-authorsJohn Rostas
2004Migues PV, Sim AT, Rostas JA, 'Changes in KCI-induced phosphorylation of AMPA and NMDA receptors during chicken brain maturation', Journal of Neurochemistry, Hong Kong (2004) [E3]
Co-authorsJohn Rostas
Show 7 more conferences
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Grants and Funding

Summary

Number of grants77
Total funding$8,217,601

Click on a grant title below to expand the full details for that specific grant.


20082 grants / $320,000

PP2A: a novel target for leukaemia therapy$300,000

Funding body: Cancer Council NSW

Funding bodyCancer Council NSW
Project TeamDoctor Nikki Verrills, Emeritus Professor Leonie Ashman, Professor Alistair Sim, Associate Professor Danilo Perrotti, Assoc. Prof Timothy Hughes, Dr David Thomas
SchemeResearch Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0187694
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

PP2A: A new target for asthma therapy$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim, Doctor Nikki Verrills, Professor John Scott, Conjoint Professor Peter Wark
SchemeNear Miss Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188395
Type Of FundingInternal
CategoryINTE
UONY

20076 grants / $1,386,250

Functional Characterisation of a New Regulatory Mechanism for CaMKII at Synapses in Vivo$526,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Alistair Sim
SchemeProject Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0186415
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Heat Shock Proteins in Myometrium$437,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Roger Smith, Emeritus Professor Peter Dunkley, Professor Alistair Sim, Conjoint Associate Professor Andrew Bisits
SchemeProject Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0186406
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

FACSAria - Fluorescence activated cell sorter$300,000

Funding body: Cancer Institute NSW

Funding bodyCancer Institute NSW
Project TeamDoctor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
SchemeResearch Infrastructure Grants
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187666
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

HMRI Contribution toward FACSAria - Fluorescence activated cell sorter$52,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
SchemeEquipment Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188207
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Differential regulation of human mast cell degranulation by discrete forms of protein phosphatase 2A$50,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamProfessor Alistair Sim, Doctor Nikki Verrills, Laureate Professor Paul Foster, Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Dr Gregory Kranias
SchemeResearch Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187247
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Polymerase Chain Reaction (PCR) machine and Spectrophotometer$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Leonie Ashman, Professor Alistair Sim, Doctor Nikki Verrills
SchemeEquipment Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188195
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

200613 grants / $2,795,202

Advanced technology for transcriptomics, genomics and gene mapping$850,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Rodney Scott, Professor Ian Dawes, Professor Ronald Trent, Professor Nicholas Hunt, Emeritus Professor Peter Bergquist, Professor Mark Baker, Emeritus Professor Peter Dunkley, Dr Ruby Lin, Conjoint Professor Peter Gibson, Professor Alistair Sim
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0185547
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

PRC Priority Research Centre for Asthma & Respiratory Diseases$524,282

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor Paul Foster, Conjoint Professor Peter Gibson, Conjoint Professor Kenneth Beagley, Emeritus Professor Michael Hensley, Professor Phil Hansbro, Professor Joerg Mattes, Professor Alistair Sim, Conjoint Professor Peter Wark
SchemePriority Research Centre
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186914
Type Of FundingInternal
CategoryINTE
UONY

PRC - Priority Research Centre for Brain & Mental Health Research (CBMHR)$524,282

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Professor Chris Levi, Professor Amanda Baker, Professor Mike Calford, Professor Trevor Day, Emeritus Professor Peter Dunkley, Professor Michael Hazelton, Professor Andrew Heathcote, Professor Brian Kelly, Conjoint Professor Vaughan Carr, Emeritus Professor Patricia Michie, Professor David Pow, Emeritus Professor John Rostas, Professor Ulli Schall, Professor Alistair Sim, Professor Mike Startup
SchemePriority Research Centre
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186947
Type Of FundingInternal
CategoryINTE
UONY

Live cell imaging facility$149,100

Funding body: Cancer Institute NSW

Funding bodyCancer Institute NSW
Project TeamDoctor Rick Thorne, Doctor Nikki Verrills, Professor Alistair Sim, Professor Gordon Burns
SchemeResearch Infrastructure Grants
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186146
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Targeting protein phosphatases to control mast cell activation$50,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamProfessor Alistair Sim, Laureate Professor Paul Foster
SchemeResearch Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186027
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Functional Characterisation of CaMKII Phosphorylate at a New Site in vivo$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Alistair Sim
SchemeNear Miss Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186059
Type Of FundingInternal
CategoryINTE
UONY

A novel approach to the control of mast cell activation$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim
SchemeNear Miss Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186063
Type Of FundingInternal
CategoryINTE
UONY

Identification of early-life signals induced in response to infection that predispose to asthma in later life$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Kenneth Beagley, Professor Alistair Sim
SchemePilot Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186699
Type Of FundingInternal
CategoryINTE
UONY

Novel protein phosphatase interactions in cancer$10,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Nikki Verrills, Professor Alistair Sim
SchemeProject Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186480
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

High speed computer for a live cell imaging system$3,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Rick Thorne, Professor Gordon Burns, Doctor Nikki Verrills, Professor Alistair Sim
SchemeEquipment Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0187279
Type Of FundingNot Known
CategoryUNKN
UONY

Human Proteome Organisation World Congress, Long Beach California, 28/10/2006 - 1/11/2006$2,400

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim
SchemeTravel Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0187003
Type Of FundingInternal
CategoryINTE
UONY

BioRad Mini-PROTEAN3 Electrophoresis system$995

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamEmeritus Professor Leonie Ashman, Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Professor Judith Scott, Professor Alistair Sim, Doctor Nikki Verrills
SchemeEquipment Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0187280
Type Of FundingNot Known
CategoryUNKN
UONY

20055 grants / $248,885

Novel Substrates for High Sensitivity MALDI$14,696

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Bruce King, Professor Alistair Sim
SchemeProject Grant
RoleInvestigator
Funding Start2005
Funding Finish2005
GNoG0184722
Type Of FundingInternal
CategoryINTE
UONY

2005 RIBG allocation$14,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim
SchemeResearch Infrastructure Block Grant (RIBG)
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185804
Type Of FundingInternal
CategoryINTE
UONY

Regulation of Insulin Secretion by Protein Phosphatases$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim
SchemeProject Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0184726
Type Of FundingInternal
CategoryINTE
UONY

12th International Conference on Second Messengers and Phosphoproteins, 10-14 July 2005$2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim
SchemeTravel Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185611
Type Of FundingInternal
CategoryINTE
UONY

20046 grants / $684,651

Differential regulation of two modes of exocytosis by protein phosphatases$393,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Alistair Sim, Emeritus Professor John Rostas
SchemeProject Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0182930
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Biacore3000-Expansion of Proteomics Facility$187,341

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Alistair Sim, Laureate Professor John Aitken, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Emeritus Professor Leonie Ashman, Professor Roger Smith, Professor Gordon Burns, Professor Adam McCluskey, Associate Professor Paul Tooney, Dr Fraser Ross, Conjoint Professor Ray Rose
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleLead
Funding Start2004
Funding Finish2004
GNoG0183030
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Biacore3000-Expansion of Proteomics Facility$70,660

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Alistair Sim
SchemeEquipment Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0184281
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Investigation of a novel molecular target for a new anti-ashtma therapy$16,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Alistair Sim
SchemeResearch Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0183752
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Regulation of the neuronal RNA binding protein, pipping by protein phosphorylation$14,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim
SchemeProject Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0183426
Type Of FundingInternal
CategoryINTE
UONY

12th International Conference on Second Messengers and Phosphoproteins, 3-7 August 2004$2,400

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim
SchemeTravel Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0184493
Type Of FundingInternal
CategoryINTE
UONY

20033 grants / $53,843

High Throughput 2-dimensional electrophoresis$36,443

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Alistair Sim
SchemeEquipment Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0183062
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Regulation of neuronal exocytosis by protein phosphatase 2A$15,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim
SchemeProject Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182371
Type Of FundingInternal
CategoryINTE
UONY

EMBO Europhosphatases 2003 Barceloa, Spain 28 June - 3 July 2003$2,400

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim
SchemeTravel Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0183232
Type Of FundingInternal
CategoryINTE
UONY

20026 grants / $937,047

Proteomic and Genomic Analysis Facility.$473,332

Funding body: Wellcome Trust

Funding bodyWellcome Trust
Project TeamProfessor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Professor Rodney Scott, Emeritus Professor Leonie Ashman
SchemeMajor Equipment Award
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181527
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Mechanisms of Glutamate Receptor Maturation in Chicken Brain$417,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor John Rostas, Dr Martin Cammarota, Professor Alistair Sim, Conjoint Associate Professor Mick Hunter, Professor Ulli Schall
SchemeProject Grant
RoleInvestigator
Funding Start2002
Funding Finish2002
GNoG0180913
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Peltier Thermal Cycler and associated equipment essential for establishing cDNA Retroviral Libraries$21,315

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Leonie Ashman, Dr Petranel Ferrao, Professor Gordon Burns, Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Dirk Van Helden, Dr Perry Hartfield
SchemeEquipment Grant
RoleInvestigator
Funding Start2002
Funding Finish2002
GNoG0181919
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The role of Protein Phosphatase 2A in synaptic vesicle transport$13,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim
SchemeProject Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181407
Type Of FundingInternal
CategoryINTE
UONY

Interaction of Protein Phosphatase 2A with the Neuron-specific RNA binding Protein, PIPPin$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim, Professor Judith Scott
SchemeProject Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181406
Type Of FundingInternal
CategoryINTE
UONY

FASEB Summer Research Conference on Protein Phosphatases, USA 13 - 19 July, 2002$2,400

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim
SchemeTravel Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0182166
Type Of FundingInternal
CategoryINTE
UONY

20015 grants / $53,940

Reciprocal Regulation of Kinases and Phosphatases in Long Term Synaptic Plasticity$15,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor John Rostas, Professor Alistair Sim, Professor Robert Callister
SchemeProject Grant
RoleInvestigator
Funding Start2001
Funding Finish2001
GNoG0180078
Type Of FundingInternal
CategoryINTE
UONY

Control of Catecholamine Synthesis by Tyrosine Hydroxylase.$13,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Peter Dunkley, Associate Professor Phillip Dickson, Emeritus Professor Ellak Von Nagy-Felsobuki, Professor Alistair Sim
SchemeProject Grant
RoleInvestigator
Funding Start2001
Funding Finish2001
GNoG0180125
Type Of FundingInternal
CategoryINTE
UONY

Thermocycler with 96 well sample block for PCR reactions. Class II Biological Safety Cabinet. Liquid Nitrogen storage Dewar & Transport Dewar$11,770

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Peter Dunkley, Professor Alistair Sim, Professor Dirk Van Helden, Professor Robert Callister
SchemeEquipment Grant
RoleInvestigator
Funding Start2001
Funding Finish2001
GNoG0181178
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Thermocycler with 96 well sample block for PCR reactions. Class II Biological Safety Cabinet. Liquid Nitrogen storage Dewar & Transport Dewar$11,770

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Peter Dunkley, Professor Alistair Sim, Professor Dirk Van Helden, Professor Robert Callister
SchemeUniversity/NHMRC Equipment Grant Funds
RoleInvestigator
Funding Start2001
Funding Finish2001
GNoG0181179
Type Of FundingInternal
CategoryINTE
UONY

EMBO Conference on Protein Phosphatases and Phosphorylation, Germany 8-12 July 2001$2,400

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim
SchemeTravel Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0181000
Type Of FundingInternal
CategoryINTE
UONY

20003 grants / $36,900

Targeting Protein Phosphatase 2A to Regulate DNA Repair.$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Alistair Sim
SchemeResearch Grant
RoleLead
Funding Start2000
Funding Finish2000
GNoG0180546
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Secretatogue-Induced Translocation of Protein Phosphatase 2A in Mast Cells.$14,500

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Alistair Sim, Dr R Ludowyke
SchemeSmall Grant
RoleLead
Funding Start2000
Funding Finish2000
GNoG0178966
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

FASEB Summer Research Conference on Protein Phosphatases, USA 23-29 July 2000$2,400

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim
SchemeTravel Grant
RoleLead
Funding Start2000
Funding Finish2000
GNoG0179852
Type Of FundingInternal
CategoryINTE
UONY

19995 grants / $568,512

Targeting of Neuronal Protein Phosphatase 2A$335,505

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Alistair Sim
SchemeProject Grant
RoleLead
Funding Start1999
Funding Finish1999
GNoG0178361
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Confocal Laser Scanning Microscope Facility.$203,107

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken, Emeritus Professor John Patrick, Conjoint Professor Christina Offler, Associate Professor David McCurdy, Conjoint Professor Ray Rose, Doctor Tim Roberts, Conjoint Associate Professor Russell Jones, Doctor John Clulow, Emeritus Professor John Rostas, Professor Alistair Sim, Professor Gordon Burns, Conjoint Professor Loris Chahl, DR DAVID KAY
SchemeLarge Equipment Grant
RoleInvestigator
Funding Start1999
Funding Finish1999
GNoG0177945
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

FPLC Protein Purification System$16,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Alistair Sim, Emeritus Professor John Rostas, Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
SchemeEquipment Grant
RoleLead
Funding Start1999
Funding Finish1999
GNoG0180790
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The Role of A-Kinase Anchoring Proteins in Directing the Specificity of Protein Phosphatase 1 Action in Neurons.$11,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim
SchemeProject Grant
RoleLead
Funding Start1999
Funding Finish1999
GNoG0178124
Type Of FundingInternal
CategoryINTE
UONY

EMBO/FEBS Conference on Protein Phosphorylation and Protein De Panne, Belgium.$2,400

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim
SchemeTravel Grant
RoleLead
Funding Start1999
Funding Finish1999
GNoG0180486
Type Of FundingInternal
CategoryINTE
UONY

19985 grants / $100,986

Molecular Dynamics Storm 860 Tri-mode Analysis System$35,000

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamProfessor Alistair Sim, Emeritus Professor John Rostas, Emeritus Professor Peter Dunkley, Dr Stephen Bunn, Dr Tat Cheah, Conjoint Professor Kenneth Beagley, Conjoint Professor Ray Rose, Professor Judith Scott, Doctor Cheng Chan, Professor Roger Smith
SchemeResearch Grant
RoleLead
Funding Start1998
Funding Finish1998
GNoG0177453
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

Control of the nervous system by protein phosphatases and anchoring prteins$19,000

Funding body: Department of Industry, Science & Resources

Funding bodyDepartment of Industry, Science & Resources
Project TeamProfessor Alistair Sim
SchemeBilateral S&T Program (Defunct)
RoleLead
Funding Start1998
Funding Finish1998
GNoG0177195
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Identification of protein phosphatases acting on Tyrosine Hydroxylase in bovine adrenal chromaffin cells.$19,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Peter Dunkley, Professor Alistair Sim, Dr Tat Cheah
SchemeProject Grant
RoleInvestigator
Funding Start1998
Funding Finish1998
GNoG0177219
Type Of FundingInternal
CategoryINTE
UONY

The Role of Protein Phosphatases in Allergic Response Mast Cell Secretion$16,486

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamProfessor Alistair Sim
SchemeResearch Grant
RoleLead
Funding Start1998
Funding Finish1998
GNoG0177600
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Characterisation of Neuronal Protein Phosphatase 1 Binding Proteins.$11,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim
SchemeProject Grant
RoleLead
Funding Start1998
Funding Finish1998
GNoG0177262
Type Of FundingInternal
CategoryINTE
UONY

19975 grants / $367,409

Role of Protein Phosphorylation in the Control of Glutamate Release from Nerve Terminals.$178,409

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Peter Dunkley, Dr B Walmsley, Professor Alistair Sim, Dr Stephen Bunn
SchemeProject Grant
RoleInvestigator
Funding Start1997
Funding Finish1997
GNoG0176252
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Characteristation of Novel Molecular Probes for Protein Phosphatases.$160,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Alistair Sim, Emeritus Professor John Rostas, Dr R Capon
SchemeLarge Grant
RoleLead
Funding Start1997
Funding Finish1997
GNoG0176188
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Modulation of Neurotransmitted Release by Carboxyl-methylation and tyrosine Phosphorylation of Protein Phosphatase type 2A.$18,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Alistair Sim, Doctor Paul Brent, Emeritus Professor Peter Dunkley
SchemeSmall Grant
RoleLead
Funding Start1997
Funding Finish1997
GNoG0176731
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Molecular Characterisation of Protein Phosphatase 2A.$8,500

Funding body: Ian Potter Foundation

Funding bodyIan Potter Foundation
Project TeamProfessor Alistair Sim
SchemeResearch Grant
RoleLead
Funding Start1997
Funding Finish1997
GNoG0176967
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Joint Meeting of the International and American Societies for Neurochemistry, Boston, USA, 20-26 July 1997$2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim
SchemeTravel Grant
RoleLead
Funding Start1997
Funding Finish1997
GNoG0179567
Type Of FundingInternal
CategoryINTE
UONY

19963 grants / $73,062

Molecular characterisation of cytoskeletal protein phosphatase 2A$60,662

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Alistair Sim
SchemeMulti-Year Small Grant Scholarship
RoleLead
Funding Start1996
Funding Finish1996
GNoG0175745
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Purchase Shaking Incubator and Peltier Thermocycler$10,000

Funding body: Ian Potter Foundation

Funding bodyIan Potter Foundation
Project TeamProfessor Alistair Sim
SchemeResearch Grant
RoleLead
Funding Start1996
Funding Finish1996
GNoG0176056
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Federation of American Societies for Experimental Biology, Colorado, USA, 21-26 July 1996$2,400

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim
SchemeTravel Grant
RoleLead
Funding Start1996
Funding Finish1996
GNoG0176477
Type Of FundingInternal
CategoryINTE
UONY

19954 grants / $249,871

Regulation of neuronal protein phosphatases types 1 & 2A.$218,471

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Alistair Sim
SchemeProject Grant
RoleLead
Funding Start1995
Funding Finish1995
GNoG0174526
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

95APP. High resolution purification of intra-cellular signalling proteins from brain by FPLC.$20,000

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamProfessor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas
SchemeResearch Grant
RoleLead
Funding Start1995
Funding Finish1995
GNoG0174696
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

Phosphorylation of glycoprotein GP-180:- Implications for NMDA-type glutamate receptor function$9,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim, Emeritus Professor John Rostas
SchemeProject Grant
RoleLead
Funding Start1995
Funding Finish1995
GNoG0174918
Type Of FundingInternal
CategoryINTE
UONY

Intern. Society for Neurochemistry, Japan, 2-7 July$2,400

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim
SchemeTravel Grant
RoleLead
Funding Start1995
Funding Finish1995
GNoG0176855
Type Of FundingInternal
CategoryINTE
UONY

19942 grants / $11,000

The control of tyrosine hydroxylase activity by protein phosphorylation.$6,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Peter Dunkley, Dr Stephen Bunn, Professor Alistair Sim
SchemeProject Grant
RoleInvestigator
Funding Start1994
Funding Finish1994
GNoG0174737
Type Of FundingInternal
CategoryINTE
UONY

Do sigma binding site ligands modulate neurotransmission by molecular mechanisms involving protein phosphorylation in neuronal tissue$5,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Paul Brent, Emeritus Professor Peter Dunkley, Professor Alistair Sim
SchemeProject Grant
RoleInvestigator
Funding Start1994
Funding Finish1994
GNoG0174732
Type Of FundingInternal
CategoryINTE
UONY

19932 grants / $122,037

Advance Warning Of Cyanobacterial Activity$119,637

Funding body: Urban Water Research Association

Funding bodyUrban Water Research Association
Project TeamProfessor Alistair Sim, Emeritus Professor John Rostas
SchemeResearch Grant
RoleLead
Funding Start1993
Funding Finish1993
GNoG0173334
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

'ISN Bien. Meet',Montpellier-22 - 27 Aug.93,'European Protein Phosphatase Meeting'Bressanone,19-23 Sept 1993,'1st Int. Symp.on Cyanobacteria,Bath,27-29Sept$2,400

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim
SchemeTravel Grant
RoleLead
Funding Start1993
Funding Finish1993
GNoG0174350
Type Of FundingInternal
CategoryINTE
UONY

19922 grants / $208,006

92,93,94GRANT. The Regulation Of Protein Phosphatases In The Brain$183,006

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas
SchemeProject Grant
RoleLead
Funding Start1992
Funding Finish1992
GNoG0174274
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Characterisation Of Novel Inhibitions And Activators Of Protein Phosphatases And Protein Kinases Isolated From Australian Marine Invertebrates.$25,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Alistair Sim
SchemeSmall Grant
RoleLead
Funding Start1992
Funding Finish1992
GNoG0173619
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY
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Research Supervision

Past Supervision

YearResearch Title / Program / Supervisor Type
2012The Role of Protein Phosphatase 2A as a Tumour Suppressor in Breast Cancer
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2011Regulation of Mast Cell Degranulation by Protein Phosphatase 2A
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2010Regulation of the Tumour Suppressor PP2A by Oncogenic Tyrosine Kinases
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2004Differential Regulation of Two Modes of Synaptic Vesicle Exocytosis by Protein Phosphorylation
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2004Yeast Two-Hybrid Analysis of Protein Phosphatase 2A Binding Proteins
Medical Science, Faculty of Health and Medicine
Sole Supervisor
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Professor Alistair Sim

Position

Conjoint Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Medical Biochemistry

Contact Details

Emailalistair.sim@newcastle.edu.au
Phone-
Fax-
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