Professor Alistair Sim

Conjoint Professor

School of Biomedical Sciences and Pharmacy (Medical Biochemistry)

Career Summary

Biography

Since my seminal work in characterising the first ever pharmacological inhibitor of protein phosphatases, I have continued to build an international and national reputation for my work that seeks to understand the ways in which these enzymes regulate cellular signalling and disease. I have made key findings in the way in which protein phosphatases respond to physiological and environmental signals and in the role these enzymes play in neurotransmission and in the initiation of asthma.

My publications have now received over 2000 citations and I am ranked in the top 15% of my field internationally. In recognition of this standing in my field I have received annual invitations to speak at key symposia at major international and national conferences. I have also established a number of mutually beneficial international collaborations in the USA and UK.

I am one of only 4 Australian researchers on the Editorial Board of The Biochemical Journal, Europes leading scientific journal for biochemistry and I sit on the Biochemistry Grant Review Panel for the National Health and Medical Research Council Australias leading medical research funding body. I have attracted funding from the Wellcome Foundation, UK to establish proteomics facilities and I am a project director of the Australian Cooperative Research Centre for Asthma and Airways new diagnostics proteomics discovery program.

I hold an international patent for anticancer therapeutics and current asthma diagnostic work is under intellectual property protection procedures.

Research Expertise
Since joining the university in 1989, I have provided national focus and international leadership in cellular signalling with a focus on the regulatory enzymes, protein phosphatases. Current focus is investigation of these key cell regulatory enzymes in the etiology and management of national priority diseases such as asthma and cancer, but also maternal health. I employ a broad range of modern molecular and cellular techniques with a major focus on proteomics for identification of molecular markers of disease

Teaching Expertise
My main teaching focus is into the medical program and the bachelor of biomedical sciences. Key expertise is in the area of cellular signaling and metabolism.

Administrative Expertise
I have occupied a broad range of senior administrative positions within my school, faculty and university.


Qualifications

  • PhD, Australian National University
  • Bachelor of Science (Honours), Aberdeen University

Keywords

  • Biochemistry
  • Cell signalling
  • Medical Biochemistry
  • asthma
  • cancer
  • cell biology
  • cell signalling
  • exocytosis
  • metabolism
  • protein kinase
  • protein phosphatase
  • protein phosphorylation
  • protein targeting
  • proteomics

Fields of Research

Code Description Percentage
060199 Biochemistry and Cell Biology not elsewhere classified 35
110199 Medical Biochemistry and Metabolomics not elsewhere classified 50
110999 Neurosciences not elsewhere classified 15

Professional Experience

UON Appointment

Title Organisation / Department

Academic appointment

Dates Title Organisation / Department
1/01/2004 - 1/06/2006 Assistant Dean Research University of Newcastle
Faculty Of Health
Australia
1/01/2002 -  Associate Professor of Medical Biochemistry University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/1998 - 1/12/2001 Senior Lecturer in Medical Biochemistry University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/1992 - 1/12/1997 Lecturer in Medical Biochemistry University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/1990 - 1/12/1991 Research Fellow University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/09/1985 - 1/12/1989 Research Fellow

Biochemistry

University of Dundee, Scotland
School of Life Sciences
United Kingdom

Membership

Dates Title Organisation / Department
Member - The Biochemical Journal The Biochemical Journal
Australia
Grant Review Panel Member - NHMRC NHMRC Committee
Australia

Awards

Recognition

Year Award
2007 Protein Phosphatase Research Portal
Unknown

Invitations

Participant

Year Title / Rationale
2006 Australian Neuroscience Society Meeting
Organisation: Australian Neuroscience Society Description: This meeting is the premier Neuroscience meeting in Australia. I was an invited symposium speaker.
2006 ), The Australian Physiology and Pharmacology Society Annual Meeting
Organisation: ), The Australian Physiology and Pharmacology Society Description: This meeting is the premier Australian conference in physiology and pharmacology. I was an invited symposium speaker
2005 Combio
Organisation: Australian Society for Biochemistry and Molecular Biology Description: Combio is Australia's premier Biochemistry meeeting. I was an invited symposium speaker
2005 FEBS Europhosphatase
Organisation: Federation of European Biochemical Societies Description: The FEBS Europhosphatase meeting is the premier international meeting in my field. All speakers are invited by the organising committee
2003 FEBS Europhosphatase Meeting
Organisation: Federation of European Biochemical Societies Description: The FEBS Europhosphatase meeting is the premier international meeting in my field. All speakers are invited by the organising committee
2002 FASEB Summery Research Conference on Protein Phosphatases
Organisation: Federation of American Society for Experimental Biology Description: The FASEB Summer Research Conference is the major biennial international conference in my field. All speakers are invited by the organising committee
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (26 outputs)

Year Citation Altmetrics Link
2013 Mate K, Sim A, Weidenhofer J, Milward L, Scott J, 'Investigation of the human disease osteogenesis imperfecta: A research-based introduction to concepts and skills in biomolecular analysis', Biochemistry & Molecular Biology Education, 41 103-109 (2013) [C1]
DOI 10.1002/bmb.20672
Citations Scopus - 1
Co-authors Karen Mate, Liz Milward, Judith Weidenhofer
2011 Verrills NM, Irwin JA, He XY, Wood LG, Powell H, Simpson JL, et al., 'Identification of novel diagnostic biomarkers for asthma and chronic obstructive pulmonary disease', American Journal of Respiratory and Critical Care Medicine, 183 1633-1643 (2011) [C1]
DOI 10.1164/rccm.201010-1623OC
Citations Scopus - 36Web of Science - 34
Co-authors Vanessa Mcdonald, Lisa Wood, Peter Gibson, Nikki Verrills, Jodie Simpson
2010 Roberts KG, Smith AM, McDougall FK, Carpenter HC, Horan MP, Neviani P, et al., 'Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers', Cancer Research, 70 5438-5447 (2010) [C1]
DOI 10.1158/0008-5472.CAN-09-2544
Citations Scopus - 56Web of Science - 52
Co-authors Nikki Verrills, Leonie Ashman
2010 Kranias G, Watt L, Carpenter HC, Holst J, Ludowyke R, Strack S, et al., 'Protein phosphatase 2A carboxymethylation and regulatory B subunits differentially regulate mast cell degranulation', Cellular Signalling, 22 1882-1890 (2010) [C1]
DOI 10.1016/j.cellsig.2010.07.017
Citations Scopus - 5Web of Science - 5
Co-authors Nikki Verrills
2006 Sim AT, Ludowyke RI, Verrills NM, 'Mast cell function: Regulation of degranulation by serine/threonine phosphatases', Pharmacology & Therapeutics, 112 425-439 (2006) [C1]
DOI 10.1016/j.pharmthera.2006.04.011
Citations Scopus - 17Web of Science - 16
Co-authors Nikki Verrills
2006 Sim AT, Herd LM, Proctor DT, Baldwin ML, Meunier FA, Rostas JA, 'High throughput analysis of endogenous glutamate release using a fluorescence plate reader', Journal of Neuroscience Methods, 153 43-47 (2006) [C1]
DOI 10.1016/j.jneumeth.2005.10.004
Citations Scopus - 2Web of Science - 2
Co-authors Lynn Herd, John Rostas
2006 Baldwin ML, Cammarota MP, Sim AT, Rostas JA, 'Src family tyrosine kinases differentially modulate exocytosis from rat brain nerve terminals', Neurochemistry International, 49 80-86 (2006) [C1]
DOI 10.1016/j.neuint.2006.01.002
Citations Scopus - 10Web of Science - 9
Co-authors John Rostas
2006 Migues PV, Lehmann IT, Fluechter L, Cammarota MP, Gurd JW, Sim AT, et al., 'Phosphorylation of CaMKII at Thr253 occurs in vivo and enhances binding to isolated postsynaptic densities', Journal of Neurochemistry, 98 289-299 (2006) [C1]
DOI 10.1111/j.1471-4159.2006.03876.x
Citations Scopus - 24Web of Science - 22
Co-authors Phil Dickson, John Rostas
2003 Baldwin ML, Rostas JA, Sim AT, 'Two modes of excytosis from synaptosomes are differentially regulated by protein phosphatase types 2A and 2B', Journal of Neurochemistry, 85 1190-1199 (2003) [C1]
DOI 10.1046/j.1471-4159.2003.01779.x
Citations Scopus - 26Web of Science - 25
Co-authors John Rostas
2003 Bevilaqua L, Cammarota MP, Dickson PW, Sim AT, Dunkley PR, 'Role of protein phosphatase 2C from bovine adrenal chromaffin cells in the dephosphorylation of phospho-serine 40 tyrosine hydroxylase', Journal of Neurochemistry, 85 1368-1373 (2003) [C1]
DOI 10.1046/j.1471-4159.2003.01792.x
Citations Scopus - 18Web of Science - 18
Co-authors Peter Dunkley, Phil Dickson
2003 Sim AT, Baldwin ML, Rostas JA, Holst J, Ludowyke RI, 'The role of serine/threonine protein phosphatases in exocytosis', Biochemical Journal, 373 641-659 (2003) [C1]
DOI 10.1042/BJ20030484
Citations Scopus - 37Web of Science - 36
Co-authors John Rostas
2002 McCluskey A, Sim A, Sakoff J, 'Serine-threonine protein phosphatase inhibitors: Development of potential therapeutic strategies', Journal of Medicinal Chemistry, 45 1151-1175 (2002) [C1]
Citations Scopus - 178Web of Science - 176
Co-authors Jennette Sakoff, Adam Mccluskey
2002 Leal R, Sim AT, Goncalves C, Dunkley PR, 'Tyrosine Hydroxylase Dephosphorylation by Protein Phosphatase 2A in Bovine Adrenal Chromaffin Cells', Neurochemical Research, 27, No 3 207-213 (2002) [C1]
Citations Scopus - 23Web of Science - 23
Co-authors Peter Dunkley
2002 McCluskey A, Atherton MA, Walkom CC, Bowyer M, Sim A, Young D, Sakoff J, 'The first two cantharidin analogues displaying PP1 selectivity', Bioorganic & Medicinal Chemistry Letters, 12 391-393 (2002) [C1]
Citations Scopus - 39Web of Science - 38
Co-authors Mirella Atherton, Michael Bowyer, Jennette Sakoff, Adam Mccluskey
2002 Sim AT, Ludowyke R, 'The Complex Nature of Protein Phosphatases', IUBMB Life, 53 283-286 (2002) [C1]
Citations Scopus - 12Web of Science - 9
2002 Holst J, Sim AT, Ludowyke R, 'Protein Phosphatases 1 and 2A Transiently Associate with Myosin during the Peak Rate of Secretion from Mast Cells', Molecular Biology of the Cell, 13 1083-1098 (2002) [C1]
Citations Scopus - 27Web of Science - 26
2001 Schillace R, Voltz J, Sim AT, Shenolikar S, Scott J, 'Multiple Interactions within the AKAP220 Signaling Complex Contribute to Protein Phosphatase 1 Regulation', Journal of Biological Chemistry, 276 No. 15 12128-12134 (2001) [C1]
Citations Scopus - 37Web of Science - 37
2001 Michell B, Chen Z-P, Tiganis T, Stapleton D, Katsis F, Power D, et al., 'Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase', Journal of Biological Chemistry, 276 17625-17628 (2001) [C1]
Citations Scopus - 373Web of Science - 347
2001 Sim AT, 'Protein Phosphatases: Regulating the Regulators', Australian Biochemist, 32 No. 1 13-15 (2001) [C1]
2000 Ludowyke RI, Holst J, Mudge L-M, Sim AT, 'Transient Translocation and Activation of Protein Phosphatase 2A during Mast Cell Secretion', The Journal of Biological Chemistry, 275 No. 9 March 3 6144-6152 (2000) [C1]
Citations Scopus - 49Web of Science - 47
2000 Lengyel I, Fieuw-Makaroff S, Hall AL, Sim AT, Rostas JA, Dunkley PR, 'Modulation of the Phosphorylation and Activity of Calcium/Calmodulin-Dependent Protein Kinase II by Zinc', Journal of Neurochemistry, 75 No. 2 594-605 (2000) [C1]
Citations Scopus - 52Web of Science - 51
Co-authors John Rostas, Peter Dunkley
2000 McCluskey A, Atherton MA, Mudgee L, Sim A, Sakoff JA, Quinn R, 'Anhydride modified cantharidin analogues. Is ring opening important in the inhibition of protein phosphatase 2A?', European Journal of Medicinal Chemistry, 35 957-964 (2000) [C1]
Citations Scopus - 41Web of Science - 39
Co-authors Mirella Atherton, Jennette Sakoff, Adam Mccluskey
2000 Bowyer MC, 'Anhydride Modified Cantharidin Analogues: Synthesis, Inhibition of Protein Phosphatases 1 and 2A and Anticancer Activity', Bioorganic & Medicinal Chemistry Letters, 10 1687-1690 (2000) [C1]
Citations Scopus - 69Web of Science - 69
Co-authors Adam Mccluskey, Jennette Sakoff, Michael Bowyer
1999 Sim AT, Scott J, 'Targeting of PKA, PKC and protein phosphatases to cellular microdomains', Cell Calcium, 26 No. 5 209-217 (1999) [C1]
Citations Web of Science - 65
1998 Capon RJ, Rooney F, Murray LM, Collins E, Sim AT, Rostas JA, et al., 'Dragmacidins: New protein phosphatase inhibitors from a Southern Australian deep-water marine sponge Spongosorites sp', Journal of Natural Products, 61 660-662 (1998) [C1]
Citations Scopus - 111Web of Science - 102
Co-authors John Rostas
1998 Sim AT, Collins E, Mudge LM, Rostas JA, 'Developmental regulation of protein phosphatase types 1 and 2A in post-hatch chicken brain', Neurochemical Research, 23(4) 487-491 (1998) [C1]
Citations Web of Science - 11
Co-authors John Rostas
Show 23 more journal articles

Review (1 outputs)

Year Citation Altmetrics Link
2003 Sim AT, Holst J, Ludowyke RI, 'Protein Phosphatase Translocation in RBL-2H3 Cells', Methods in Enzymology (2003) [D1]

Conference (10 outputs)

Year Citation Altmetrics Link
2010 Verrills NM, Roberts KG, Smith AM, McDougall FK, Carpenter HC, Neviani P, et al., 'Targeting the tumour suppressor, PP2A, as a novel therapy for acute myeloid leukaemia', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
Co-authors Nikki Verrills, Leonie Ashman
2009 Kranias G, Cottrell LF, Carpenter HC, Sim AT, Verrills NM, 'Protein phosphatase 2A carboxymethylation and regulatory B subunits differentially regulate mast cell degranulation', FEBS Journal, Prague, Czech Republic (2009) [E3]
Co-authors Nikki Verrills
2009 Skelding KA, Liao X, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Functional consequences of CaMKII phosphorylation at THR253 in neurons', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authors Kathryn Skelding, John Rostas, Nikki Verrills, Phil Dickson
2008 Skelding KA, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Identification of CaMKII binding proteins in brain sensitive to CaMKII phosphorylation state', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authors Kathryn Skelding, John Rostas, Nikki Verrills, Phil Dickson
2008 Skelding KA, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Development of a novel method for the identification of CaMKII binding proteins', Journal of Neurochemistry, Shanghai, China (2008) [E3]
Co-authors Phil Dickson, Nikki Verrills, John Rostas, Kathryn Skelding
2007 Roberts KG, Ashman LK, Sim AT, Verrills NM, 'Regulation of protein phosphatase 2A (PP2A) B subunits by Bcr/Abl: Potential targets for chronic myeloid leukemia', AACR Meeting Abstracts Online (Abstracts of the 98th AACR Annual Meeting), Los Angeles (2007) [E3]
Co-authors Nikki Verrills, Leonie Ashman
2006 Rostas JA, Migues PV, Fluechter L, Dickson PW, Sim AT, Rawoff S, et al., 'Phosphorylation of CAMKII at T253 induced by transient global ischaemia', Proceedings of the Australian Neuroscience Society, Sydney (2006) [E3]
Co-authors John Rostas, Phil Dickson
2006 Verrills NM, Carpenter HC, Sim AT, 'Disruption of Actin-containing Protein Phosphatase 2A Complexes Regulates Cell Motility in Neuroblastoma Cells', Molecular & Cellular Proteomics, California, USA (2006) [E3]
Co-authors Nikki Verrills
2004 Rostas JA, Baldwin ML, Cammarota MP, Sim AT, 'The regulation of synaptosomal exocytosis by Src tyrosine kinases', Journal of Neurochemistry, Hong Kong (2004) [E3]
Co-authors John Rostas
2004 Migues PV, Sim AT, Rostas JA, 'Changes in KCI-induced phosphorylation of AMPA and NMDA receptors during chicken brain maturation', Journal of Neurochemistry, Hong Kong (2004) [E3]
Co-authors John Rostas
Show 7 more conferences
Edit

Grants and Funding

Summary

Number of grants 77
Total funding $8,217,601

Click on a grant title below to expand the full details for that specific grant.


20082 grants / $320,000

PP2A: a novel target for leukaemia therapy$300,000

Funding body: Cancer Council NSW

Funding body Cancer Council NSW
Project Team Doctor Nikki Verrills, Emeritus Professor Leonie Ashman, Professor Alistair Sim, Associate Professor Danilo Perrotti, Assoc. Prof Timothy Hughes, Dr David Thomas
Scheme Research Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0187694
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

PP2A: A new target for asthma therapy$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim, Doctor Nikki Verrills, Professor John Scott, Conjoint Professor Peter Wark
Scheme Near Miss Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188395
Type Of Funding Internal
Category INTE
UON Y

20076 grants / $1,386,250

Functional Characterisation of a New Regulatory Mechanism for CaMKII at Synapses in Vivo$526,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Alistair Sim
Scheme Project Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0186415
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Heat Shock Proteins in Myometrium$437,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Roger Smith, Emeritus Professor Peter Dunkley, Professor Alistair Sim, Conjoint Associate Professor Andrew Bisits
Scheme Project Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0186406
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

FACSAria - Fluorescence activated cell sorter$300,000

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Doctor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
Scheme Research Infrastructure Grants
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187666
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

HMRI Contribution toward FACSAria - Fluorescence activated cell sorter$52,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
Scheme Equipment Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188207
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Differential regulation of human mast cell degranulation by discrete forms of protein phosphatase 2A$50,000

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Professor Alistair Sim, Doctor Nikki Verrills, Laureate Professor Paul Foster, Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Dr Gregory Kranias
Scheme Research Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0187247
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Polymerase Chain Reaction (PCR) machine and Spectrophotometer$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Leonie Ashman, Professor Alistair Sim, Doctor Nikki Verrills
Scheme Equipment Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188195
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

200613 grants / $2,795,202

Advanced technology for transcriptomics, genomics and gene mapping$850,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Rodney Scott, Professor Ian Dawes, Professor Ronald Trent, Professor Nicholas Hunt, Emeritus Professor Peter Bergquist, Professor Mark Baker, Emeritus Professor Peter Dunkley, Dr Ruby Lin, Conjoint Professor Peter Gibson, Professor Alistair Sim
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0185547
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

PRC Priority Research Centre for Asthma & Respiratory Diseases$524,282

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Laureate Professor Paul Foster, Conjoint Professor Peter Gibson, Conjoint Professor Kenneth Beagley, Emeritus Professor Michael Hensley, Professor Phil Hansbro, Professor Joerg Mattes, Professor Alistair Sim, Conjoint Professor Peter Wark
Scheme Priority Research Centre
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186914
Type Of Funding Internal
Category INTE
UON Y

PRC - Priority Research Centre for Brain & Mental Health Research (CBMHR)$524,282

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Chris Levi, Professor Amanda Baker, Professor Mike Calford, Professor Trevor Day, Emeritus Professor Peter Dunkley, Professor Michael Hazelton, Professor Andrew Heathcote, Professor Brian Kelly, Conjoint Professor Vaughan Carr, Emeritus Professor Patricia Michie, Professor David Pow, Emeritus Professor John Rostas, Professor Ulli Schall, Professor Alistair Sim, Professor Mike Startup
Scheme Priority Research Centre
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186947
Type Of Funding Internal
Category INTE
UON Y

Live cell imaging facility$149,100

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Doctor Rick Thorne, Doctor Nikki Verrills, Professor Alistair Sim, Professor Gordon Burns
Scheme Research Infrastructure Grants
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186146
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Targeting protein phosphatases to control mast cell activation$50,000

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Professor Alistair Sim, Laureate Professor Paul Foster
Scheme Research Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0186027
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Functional Characterisation of CaMKII Phosphorylate at a New Site in vivo$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Alistair Sim
Scheme Near Miss Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186059
Type Of Funding Internal
Category INTE
UON Y

A novel approach to the control of mast cell activation$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim
Scheme Near Miss Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0186063
Type Of Funding Internal
Category INTE
UON Y

Identification of early-life signals induced in response to infection that predispose to asthma in later life$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Kenneth Beagley, Professor Alistair Sim
Scheme Pilot Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186699
Type Of Funding Internal
Category INTE
UON Y

Novel protein phosphatase interactions in cancer$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Nikki Verrills, Professor Alistair Sim
Scheme Project Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186480
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

High speed computer for a live cell imaging system$3,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Rick Thorne, Professor Gordon Burns, Doctor Nikki Verrills, Professor Alistair Sim
Scheme Equipment Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0187279
Type Of Funding Not Known
Category UNKN
UON Y

Human Proteome Organisation World Congress, Long Beach California, 28/10/2006 - 1/11/2006$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim
Scheme Travel Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0187003
Type Of Funding Internal
Category INTE
UON Y

BioRad Mini-PROTEAN3 Electrophoresis system$995

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Emeritus Professor Leonie Ashman, Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Professor Judith Scott, Professor Alistair Sim, Doctor Nikki Verrills
Scheme Equipment Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0187280
Type Of Funding Not Known
Category UNKN
UON Y

20055 grants / $248,885

Novel Substrates for High Sensitivity MALDI$14,696

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Bruce King, Professor Alistair Sim
Scheme Project Grant
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0184722
Type Of Funding Internal
Category INTE
UON Y

2005 RIBG allocation$14,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim
Scheme Research Infrastructure Block Grant (RIBG)
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0185804
Type Of Funding Internal
Category INTE
UON Y

Regulation of Insulin Secretion by Protein Phosphatases$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim
Scheme Project Grant
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0184726
Type Of Funding Internal
Category INTE
UON Y

12th International Conference on Second Messengers and Phosphoproteins, 10-14 July 2005$2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim
Scheme Travel Grant
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0185611
Type Of Funding Internal
Category INTE
UON Y

20046 grants / $684,651

Differential regulation of two modes of exocytosis by protein phosphatases$393,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alistair Sim, Emeritus Professor John Rostas
Scheme Project Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0182930
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Biacore3000-Expansion of Proteomics Facility$187,341

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Alistair Sim, Laureate Professor John Aitken, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Emeritus Professor Leonie Ashman, Professor Roger Smith, Professor Gordon Burns, Professor Adam McCluskey, Associate Professor Paul Tooney, Dr Fraser Ross, Conjoint Professor Ray Rose
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0183030
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Biacore3000-Expansion of Proteomics Facility$70,660

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alistair Sim
Scheme Equipment Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0184281
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Investigation of a novel molecular target for a new anti-ashtma therapy$16,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Alistair Sim
Scheme Research Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0183752
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Regulation of the neuronal RNA binding protein, pipping by protein phosphorylation$14,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim
Scheme Project Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0183426
Type Of Funding Internal
Category INTE
UON Y

12th International Conference on Second Messengers and Phosphoproteins, 3-7 August 2004$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim
Scheme Travel Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0184493
Type Of Funding Internal
Category INTE
UON Y

20033 grants / $53,843

High Throughput 2-dimensional electrophoresis$36,443

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alistair Sim
Scheme Equipment Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0183062
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Regulation of neuronal exocytosis by protein phosphatase 2A$15,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim
Scheme Project Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0182371
Type Of Funding Internal
Category INTE
UON Y

EMBO Europhosphatases 2003 Barceloa, Spain 28 June - 3 July 2003$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim
Scheme Travel Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0183232
Type Of Funding Internal
Category INTE
UON Y

20026 grants / $937,047

Proteomic and Genomic Analysis Facility.$473,332

Funding body: Wellcome Trust

Funding body Wellcome Trust
Project Team Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Professor Rodney Scott, Emeritus Professor Leonie Ashman
Scheme Major Equipment Award
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0181527
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Mechanisms of Glutamate Receptor Maturation in Chicken Brain$417,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor John Rostas, Dr Martin Cammarota, Professor Alistair Sim, Conjoint Associate Professor Mick Hunter, Professor Ulli Schall
Scheme Project Grant
Role Investigator
Funding Start 2002
Funding Finish 2002
GNo G0180913
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Peltier Thermal Cycler and associated equipment essential for establishing cDNA Retroviral Libraries$21,315

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Leonie Ashman, Dr Petranel Ferrao, Professor Gordon Burns, Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Dirk Van Helden, Dr Perry Hartfield
Scheme Equipment Grant
Role Investigator
Funding Start 2002
Funding Finish 2002
GNo G0181919
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The role of Protein Phosphatase 2A in synaptic vesicle transport$13,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim
Scheme Project Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0181407
Type Of Funding Internal
Category INTE
UON Y

Interaction of Protein Phosphatase 2A with the Neuron-specific RNA binding Protein, PIPPin$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim, Professor Judith Scott
Scheme Project Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0181406
Type Of Funding Internal
Category INTE
UON Y

FASEB Summer Research Conference on Protein Phosphatases, USA 13 - 19 July, 2002$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim
Scheme Travel Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0182166
Type Of Funding Internal
Category INTE
UON Y

20015 grants / $53,940

Reciprocal Regulation of Kinases and Phosphatases in Long Term Synaptic Plasticity$15,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor John Rostas, Professor Alistair Sim, Professor Robert Callister
Scheme Project Grant
Role Investigator
Funding Start 2001
Funding Finish 2001
GNo G0180078
Type Of Funding Internal
Category INTE
UON Y

Control of Catecholamine Synthesis by Tyrosine Hydroxylase.$13,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson, Emeritus Professor Ellak Von Nagy-Felsobuki, Professor Alistair Sim
Scheme Project Grant
Role Investigator
Funding Start 2001
Funding Finish 2001
GNo G0180125
Type Of Funding Internal
Category INTE
UON Y

Thermocycler with 96 well sample block for PCR reactions. Class II Biological Safety Cabinet. Liquid Nitrogen storage Dewar & Transport Dewar$11,770

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Peter Dunkley, Professor Alistair Sim, Professor Dirk Van Helden, Professor Robert Callister
Scheme Equipment Grant
Role Investigator
Funding Start 2001
Funding Finish 2001
GNo G0181178
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Thermocycler with 96 well sample block for PCR reactions. Class II Biological Safety Cabinet. Liquid Nitrogen storage Dewar & Transport Dewar$11,770

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Peter Dunkley, Professor Alistair Sim, Professor Dirk Van Helden, Professor Robert Callister
Scheme University/NHMRC Equipment Grant Funds
Role Investigator
Funding Start 2001
Funding Finish 2001
GNo G0181179
Type Of Funding Internal
Category INTE
UON Y

EMBO Conference on Protein Phosphatases and Phosphorylation, Germany 8-12 July 2001$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim
Scheme Travel Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0181000
Type Of Funding Internal
Category INTE
UON Y

20003 grants / $36,900

Targeting Protein Phosphatase 2A to Regulate DNA Repair.$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Alistair Sim
Scheme Research Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0180546
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Secretatogue-Induced Translocation of Protein Phosphatase 2A in Mast Cells.$14,500

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Alistair Sim, Dr R Ludowyke
Scheme Small Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0178966
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

FASEB Summer Research Conference on Protein Phosphatases, USA 23-29 July 2000$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim
Scheme Travel Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0179852
Type Of Funding Internal
Category INTE
UON Y

19995 grants / $568,512

Targeting of Neuronal Protein Phosphatase 2A$335,505

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alistair Sim
Scheme Project Grant
Role Lead
Funding Start 1999
Funding Finish 1999
GNo G0178361
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Confocal Laser Scanning Microscope Facility.$203,107

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Laureate Professor John Aitken, Emeritus Professor John Patrick, Conjoint Professor Christina Offler, Associate Professor David McCurdy, Conjoint Professor Ray Rose, Doctor Tim Roberts, Conjoint Associate Professor Russell Jones, Doctor John Clulow, Emeritus Professor John Rostas, Professor Alistair Sim, Professor Gordon Burns, Conjoint Professor Loris Chahl, DR DAVID KAY
Scheme Large Equipment Grant
Role Investigator
Funding Start 1999
Funding Finish 1999
GNo G0177945
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

FPLC Protein Purification System$16,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alistair Sim, Emeritus Professor John Rostas, Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
Scheme Equipment Grant
Role Lead
Funding Start 1999
Funding Finish 1999
GNo G0180790
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The Role of A-Kinase Anchoring Proteins in Directing the Specificity of Protein Phosphatase 1 Action in Neurons.$11,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim
Scheme Project Grant
Role Lead
Funding Start 1999
Funding Finish 1999
GNo G0178124
Type Of Funding Internal
Category INTE
UON Y

EMBO/FEBS Conference on Protein Phosphorylation and Protein De Panne, Belgium.$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim
Scheme Travel Grant
Role Lead
Funding Start 1999
Funding Finish 1999
GNo G0180486
Type Of Funding Internal
Category INTE
UON Y

19985 grants / $100,986

Molecular Dynamics Storm 860 Tri-mode Analysis System$35,000

Funding body: Ramaciotti Foundations

Funding body Ramaciotti Foundations
Project Team Professor Alistair Sim, Emeritus Professor John Rostas, Emeritus Professor Peter Dunkley, Dr Stephen Bunn, Dr Tat Cheah, Conjoint Professor Kenneth Beagley, Conjoint Professor Ray Rose, Professor Judith Scott, Doctor Cheng Chan, Professor Roger Smith
Scheme Research Grant
Role Lead
Funding Start 1998
Funding Finish 1998
GNo G0177453
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Control of the nervous system by protein phosphatases and anchoring prteins$19,000

Funding body: Department of Industry, Science & Resources

Funding body Department of Industry, Science & Resources
Project Team Professor Alistair Sim
Scheme Bilateral S&T Program (Defunct)
Role Lead
Funding Start 1998
Funding Finish 1998
GNo G0177195
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Identification of protein phosphatases acting on Tyrosine Hydroxylase in bovine adrenal chromaffin cells.$19,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Peter Dunkley, Professor Alistair Sim, Dr Tat Cheah
Scheme Project Grant
Role Investigator
Funding Start 1998
Funding Finish 1998
GNo G0177219
Type Of Funding Internal
Category INTE
UON Y

The Role of Protein Phosphatases in Allergic Response Mast Cell Secretion$16,486

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Professor Alistair Sim
Scheme Research Grant
Role Lead
Funding Start 1998
Funding Finish 1998
GNo G0177600
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Characterisation of Neuronal Protein Phosphatase 1 Binding Proteins.$11,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim
Scheme Project Grant
Role Lead
Funding Start 1998
Funding Finish 1998
GNo G0177262
Type Of Funding Internal
Category INTE
UON Y

19975 grants / $367,409

Role of Protein Phosphorylation in the Control of Glutamate Release from Nerve Terminals.$178,409

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Peter Dunkley, Dr B Walmsley, Professor Alistair Sim, Dr Stephen Bunn
Scheme Project Grant
Role Investigator
Funding Start 1997
Funding Finish 1997
GNo G0176252
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Characteristation of Novel Molecular Probes for Protein Phosphatases.$160,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Alistair Sim, Emeritus Professor John Rostas, Dr R Capon
Scheme Large Grant
Role Lead
Funding Start 1997
Funding Finish 1997
GNo G0176188
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Modulation of Neurotransmitted Release by Carboxyl-methylation and tyrosine Phosphorylation of Protein Phosphatase type 2A.$18,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Alistair Sim, Doctor Paul Brent, Emeritus Professor Peter Dunkley
Scheme Small Grant
Role Lead
Funding Start 1997
Funding Finish 1997
GNo G0176731
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Molecular Characterisation of Protein Phosphatase 2A.$8,500

Funding body: Ian Potter Foundation

Funding body Ian Potter Foundation
Project Team Professor Alistair Sim
Scheme Research Grant
Role Lead
Funding Start 1997
Funding Finish 1997
GNo G0176967
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Joint Meeting of the International and American Societies for Neurochemistry, Boston, USA, 20-26 July 1997$2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim
Scheme Travel Grant
Role Lead
Funding Start 1997
Funding Finish 1997
GNo G0179567
Type Of Funding Internal
Category INTE
UON Y

19963 grants / $73,062

Molecular characterisation of cytoskeletal protein phosphatase 2A$60,662

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Alistair Sim
Scheme Multi-Year Small Grant Scholarship
Role Lead
Funding Start 1996
Funding Finish 1996
GNo G0175745
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Purchase Shaking Incubator and Peltier Thermocycler$10,000

Funding body: Ian Potter Foundation

Funding body Ian Potter Foundation
Project Team Professor Alistair Sim
Scheme Research Grant
Role Lead
Funding Start 1996
Funding Finish 1996
GNo G0176056
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Federation of American Societies for Experimental Biology, Colorado, USA, 21-26 July 1996$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim
Scheme Travel Grant
Role Lead
Funding Start 1996
Funding Finish 1996
GNo G0176477
Type Of Funding Internal
Category INTE
UON Y

19954 grants / $249,871

Regulation of neuronal protein phosphatases types 1 & 2A.$218,471

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alistair Sim
Scheme Project Grant
Role Lead
Funding Start 1995
Funding Finish 1995
GNo G0174526
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

95APP. High resolution purification of intra-cellular signalling proteins from brain by FPLC.$20,000

Funding body: Ramaciotti Foundations

Funding body Ramaciotti Foundations
Project Team Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas
Scheme Research Grant
Role Lead
Funding Start 1995
Funding Finish 1995
GNo G0174696
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Phosphorylation of glycoprotein GP-180:- Implications for NMDA-type glutamate receptor function$9,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim, Emeritus Professor John Rostas
Scheme Project Grant
Role Lead
Funding Start 1995
Funding Finish 1995
GNo G0174918
Type Of Funding Internal
Category INTE
UON Y

Intern. Society for Neurochemistry, Japan, 2-7 July$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim
Scheme Travel Grant
Role Lead
Funding Start 1995
Funding Finish 1995
GNo G0176855
Type Of Funding Internal
Category INTE
UON Y

19942 grants / $11,000

The control of tyrosine hydroxylase activity by protein phosphorylation.$6,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Peter Dunkley, Dr Stephen Bunn, Professor Alistair Sim
Scheme Project Grant
Role Investigator
Funding Start 1994
Funding Finish 1994
GNo G0174737
Type Of Funding Internal
Category INTE
UON Y

Do sigma binding site ligands modulate neurotransmission by molecular mechanisms involving protein phosphorylation in neuronal tissue$5,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Paul Brent, Emeritus Professor Peter Dunkley, Professor Alistair Sim
Scheme Project Grant
Role Investigator
Funding Start 1994
Funding Finish 1994
GNo G0174732
Type Of Funding Internal
Category INTE
UON Y

19932 grants / $122,037

Advance Warning Of Cyanobacterial Activity$119,637

Funding body: Urban Water Research Association

Funding body Urban Water Research Association
Project Team Professor Alistair Sim, Emeritus Professor John Rostas
Scheme Research Grant
Role Lead
Funding Start 1993
Funding Finish 1993
GNo G0173334
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

'ISN Bien. Meet',Montpellier-22 - 27 Aug.93,'European Protein Phosphatase Meeting'Bressanone,19-23 Sept 1993,'1st Int. Symp.on Cyanobacteria,Bath,27-29Sept$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alistair Sim
Scheme Travel Grant
Role Lead
Funding Start 1993
Funding Finish 1993
GNo G0174350
Type Of Funding Internal
Category INTE
UON Y

19922 grants / $208,006

92,93,94GRANT. The Regulation Of Protein Phosphatases In The Brain$183,006

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas
Scheme Project Grant
Role Lead
Funding Start 1992
Funding Finish 1992
GNo G0174274
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Characterisation Of Novel Inhibitions And Activators Of Protein Phosphatases And Protein Kinases Isolated From Australian Marine Invertebrates.$25,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Alistair Sim
Scheme Small Grant
Role Lead
Funding Start 1992
Funding Finish 1992
GNo G0173619
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y
Edit

Research Supervision

Past Supervision

Year Research Title / Program / Supervisor Type
2012 The Role of Protein Phosphatase 2A as a Tumour Suppressor in Breast Cancer
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2011 Regulation of Mast Cell Degranulation by Protein Phosphatase 2A
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2010 Regulation of the Tumour Suppressor PP2A by Oncogenic Tyrosine Kinases
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2004 Differential Regulation of Two Modes of Synaptic Vesicle Exocytosis by Protein Phosphorylation
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2004 Yeast Two-Hybrid Analysis of Protein Phosphatase 2A Binding Proteins
Medical Science, Faculty of Health and Medicine
Sole Supervisor
Edit

Professor Alistair Sim

Position

Conjoint Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Medical Biochemistry

Contact Details

Email alistair.sim@newcastle.edu.au
Phone -
Fax -
Edit