Staff Profile

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Career Summary

Biography

Since my seminal work in characterising the first ever pharmacological inhibitor of protein phosphatases, I have continued to build an international and national reputation for my work that seeks to understand the ways in which these enzymes regulate cellular signalling and disease. I have made key findings in the way in which protein phosphatases respond to physiological and environmental signals and in the role these enzymes play in neurotransmission and in the initiation of asthma. My publications have now received over 2000 citations and I am ranked in the top 15% of my field internationally. In recognition of this standing in my field I have received annual invitations to speak at key symposia at major international and national conferences. I have also established a number of mutually beneficial international collaborations in the USA and UK. I am one of only 4 Australian researchers on the Editorial Board of The Biochemical Journal, Europes leading scientific journal for biochemistry and I sit on the Biochemistry Grant Review Panel for the National Health and Medical Research Council Australias leading medical research funding body. I have attracted funding from the Wellcome Foundation, UK to establish proteomics facilities and I am a project director of the Australian Cooperative Research Centre for Asthma and Airways new diagnostics proteomics discovery program. I hold an international patent for anticancer therapeutics and current asthma diagnostic work is under intellectual property protection procedures.

Qualifications

  • PhD, Australian National University
  • Bachelor of Science (Honours), Aberdeen University

Research

Research keywords

  • asthma
  • cancer
  • cell biology
  • cell signalling
  • exocytosis
  • protein kinase
  • protein phosphatase
  • protein phosphorylation
  • protein targeting
  • proteomics

Research expertise

Since joining the university in 1989, I have provided national focus and international leadership in cellular signalling with a focus on the regulatory enzymes, protein phosphatases. Current focus is investigation of these key cell regulatory enzymes in the etiology and management of national priority diseases such as asthma and cancer, but also maternal health. I employ a broad range of modern molecular and cellular techniques with a major focus on proteomics for identification of molecular markers of disease

Fields of Research

CodeDescriptionPercentage
110199Medical Biochemistry And Metabolomics Not Elsewhere Classified50
060199Biochemistry And Cell Biology Not Elsewhere Classified35
110900Neurosciences15

Memberships

Editorial Board.

  • Member - The Biochemical Journal

NHMRC Committee

  • Grant Review Panel Member - NHMRC

Appointments

Assistant Dean Research,
Faculty of Health, The University of Newcastle (Australia)
01/01/2004 - 01/06/2006

Awards

Recognition.

2007Protein Phosphatase Research Portal
Ion Channel Media Group (United States)
This is an independent international organisation which ranks all investigators in my field (protein phosphatases) according to the number and citations of publications. It contains over 5000 investigators and I am ranked in the top 15%. See http://www.phosphatase.net/showauthor.php?surname=Sim&initials=AT

Invitations

), The Australian Physiology and Pharmacology Society Annual Meeting
), The Australian Physiology and Pharmacology Society, Australia (Conference Presentation - non published.)
2006
Australian Neuroscience Society Meeting
Australian Neuroscience Society , Australia (Conference Presentation - non published.)
2006
Combio
Australian Society for Biochemistry and Molecular Biology, Australia (Conference Presentation - non published.)
2005
FASEB Summery Research Conference on Protein Phosphatases
Federation of American Society for Experimental Biology, United States (Conference Presentation - non published.)
2002
FEBS Europhosphatase
Federation of European Biochemical Societies, Spain (Conference Presentation - non published.)
2005
FEBS Europhosphatase Meeting
Federation of European Biochemical Societies, Belgium (Conference Presentation - non published.)
2003

Administrative

Administrative expertise

I have occupied a broad range of senior administrative positions within my school, faculty and university.

Teaching

Teaching keywords

  • Biochemistry
  • Cell signalling
  • Medical Biochemistry
  • metabolism

Teaching expertise

My main teaching focus is into the medical program and the bachelor of biomedical sciences. Key expertise is in the area of cellular signaling and metabolism.

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Highlighted Publications

For publications that are currently unpublished or in-press, details are shown in italics.

YearCitationAltmetricsLink
2001Michell B, Chen Z-P, Tiganis T, Stapleton D, Katsis F, Power D, et al., 'Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase', Journal of Biological Chemistry, 276 17625-17628 (2001) [C1]
2001Schillace R, Voltz J, Sim AT, Shenolikar S, Scott J, 'Multiple Interactions within the AKAP220 Signaling Complex Contribute to Protein Phosphatase 1 Regulation', Journal of Biological Chemistry, 276 No. 15 12128-12134 (2001) [C1]
2002Holst J, Sim AT, Ludowyke R, 'Protein Phosphatases 1 and 2A Transiently Associate with Myosin during the Peak Rate of Secretion from Mast Cells', Molecular Biology of the Cell, 13 1083-1098 (2002) [C1]
2003Baldwin ML, Rostas JA, Sim AT, 'Two modes of excytosis from synaptosomes are differentially regulated by protein phosphatase types 2A and 2B', Journal of Neurochemistry, 85 1190-1199 (2003) [C1]

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (26 outputs)

YearCitationAltmetricsLink
2013Mate K, Sim A, Weidenhofer J, Milward L, Scott J, 'Investigation of the human disease osteogenesis imperfecta: A research-based introduction to concepts and skills in biomolecular analysis', Biochemistry & Molecular Biology Education, 41 103-109 (2013) [C1]
2011Verrills NM, Irwin JA, He XY, Wood LG, Powell H, Simpson JL, et al., 'Identification of novel diagnostic biomarkers for asthma and chronic obstructive pulmonary disease', American Journal of Respiratory and Critical Care Medicine, 183 1633-1643 (2011) [C1]
2010Roberts KG, Smith AM, McDougall FK, Carpenter HC, Horan MP, Neviani P, et al., 'Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers', Cancer Research, 70 5438-5447 (2010) [C1]
2010Kranias G, Watt L, Carpenter HC, Holst J, Ludowyke R, Strack S, et al., 'Protein phosphatase 2A carboxymethylation and regulatory B subunits differentially regulate mast cell degranulation', Cellular Signalling, 22 1882-1890 (2010) [C1]
2006Migues PV, Lehmann IT, Fluechter L, Cammarota MP, Gurd JW, Sim AT, et al., 'Phosphorylation of CaMKII at Thr253 occurs in vivo and enhances binding to isolated postsynaptic densities', Journal of Neurochemistry, 98 289-299 (2006) [C1]
2006Sim AT, Ludowyke RI, Verrills NM, 'Mast cell function: Regulation of degranulation by serine/threonine phosphatases', Pharmacology & Therapeutics, 112 425-439 (2006) [C1]
2006Sim AT, Herd LM, Proctor DT, Baldwin ML, Meunier FA, Rostas JA, 'High throughput analysis of endogenous glutamate release using a fluorescence plate reader', Journal of Neuroscience Methods, 153 43-47 (2006) [C1]
2006Baldwin ML, Cammarota MP, Sim AT, Rostas JA, 'Src family tyrosine kinases differentially modulate exocytosis from rat brain nerve terminals', Neurochemistry International, 49 80-86 (2006) [C1]
2003Sim AT, Baldwin ML, Rostas JA, Holst J, Ludowyke RI, 'The role of serine/threonine protein phosphatases in exocytosis', Biochemical Journal, 373 641-659 (2003) [C1]
2003Bevilaqua L, Cammarota MP, Dickson PW, Sim AT, Dunkley PR, 'Role of protein phosphatase 2C from bovine adrenal chromaffin cells in the dephosphorylation of phospho-serine 40 tyrosine hydroxylase', Journal of Neurochemistry, 85 1368-1373 (2003) [C1]
2003Baldwin ML, Rostas JA, Sim AT, 'Two modes of excytosis from synaptosomes are differentially regulated by protein phosphatase types 2A and 2B', Journal of Neurochemistry, 85 1190-1199 (2003) [C1]
2002McCluskey A, Keane M, Walkom C, Bowyer M, Sim AT, Young D, Sakoff J, 'The First Two Cantharidin Analogues Displaying PP1 Selectivity', Bioorganic & Medicinal Chemistry Letters, 12 391-393 (2002) [C1]
2002Sim AT, Ludowyke R, 'The Complex Nature of Protein Phosphatases', IUBMB Life, 53 283-286 (2002) [C1]
2002Holst J, Sim AT, Ludowyke R, 'Protein Phosphatases 1 and 2A Transiently Associate with Myosin during the Peak Rate of Secretion from Mast Cells', Molecular Biology of the Cell, 13 1083-1098 (2002) [C1]
2002McCluskey A, Sim AT, Sakoff J, 'Serine-Threonine Protein Phosphatase Inhibitors: Development of Potential Therapeutic Strategies', Journal of Medicinal Chemistry, 45, No 6 1151-1175 (2002) [C1]
2002Leal R, Sim AT, Goncalves C, Dunkley PR, 'Tyrosine Hydroxylase Dephosphorylation by Protein Phosphatase 2A in Bovine Adrenal Chromaffin Cells', Neurochemical Research, 27, No 3 207-213 (2002) [C1]

Co-authors: Peter Dunkley

2001Sim AT, 'Protein Phosphatases: Regulating the Regulators', Australian Biochemist, 32 No. 1 13-15 (2001) [C1]
2001Schillace R, Voltz J, Sim AT, Shenolikar S, Scott J, 'Multiple Interactions within the AKAP220 Signaling Complex Contribute to Protein Phosphatase 1 Regulation', Journal of Biological Chemistry, 276 No. 15 12128-12134 (2001) [C1]
2001Michell B, Chen Z-P, Tiganis T, Stapleton D, Katsis F, Power D, et al., 'Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase', Journal of Biological Chemistry, 276 17625-17628 (2001) [C1]
2000Ludowyke RI, Holst J, Mudge L-M, Sim AT, 'Transient Translocation and Activation of Protein Phosphatase 2A during Mast Cell Secretion', The Journal of Biological Chemistry, 275 No. 9 March 3 6144-6152 (2000) [C1]
2000Bowyer MC, 'Anhydride Modified Cantharidin Analogues: Synthesis, Inhibition of Protein Phosphatases 1 and 2A and Anticancer Activity', Bioorganic & Medicinal Chemistry Letters, 10 1687-1690 (2000) [C1]
2000McCluskey A, Atherton MA, Mudgee L, Sim A, Sakoff JA, Quinn R, 'Anhydride modified cantharidin analogues. Is ring opening important in the inhibition of protein phosphatase 2A?', European Journal of Medicinal Chemistry, 35 957-964 (2000) [C1]
2000Lengyel I, Fieuw-Makaroff S, Hall AL, Sim AT, Rostas JA, Dunkley PR, 'Modulation of the Phosphorylation and Activity of Calcium/Calmodulin-Dependent Protein Kinase II by Zinc', Journal of Neurochemistry, 75 No. 2 594-605 (2000) [C1]
1999Sim AT, Scott J, 'Targeting of PKA, PKC and protein phosphatases to cellular microdomains', Cell Calcium, 26 No. 5 209-217 (1999) [C1]
1998Capon RJ, Rooney F, Murray LM, Collins E, Sim AT, Rostas JA, et al., 'Dragmacidins: New protein phosphatase inhibitors from a Southern Australian deep-water marine sponge Spongosorites sp', Journal of Natural Products, 61 660-662 (1998) [C1]

Co-authors: John Rostas

1998Sim AT, Collins E, Mudge LM, Rostas JA, 'Developmental regulation of protein phosphatase types 1 and 2A in post-hatch chicken brain', Neurochemical Research, 23(4) 487-491 (1998) [C1]

Co-authors: John Rostas

Show 23 more

Review (1 outputs)

YearCitationAltmetricsLink
2003Sim AT, Holst J, Ludowyke RI, 'Protein Phosphatase Translocation in RBL-2H3 Cells', Methods in Enzymology (2003) [D1]

Conference (10 outputs)

YearCitationAltmetricsLink
2010Verrills NM, Roberts KG, Smith AM, McDougall FK, Carpenter HC, Neviani P, et al., 'Targeting the tumour suppressor, PP2A, as a novel therapy for acute myeloid leukaemia', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
2009Skelding KA, Liao X, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Functional consequences of CaMKII phosphorylation at THR253 in neurons', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
2009Kranias G, Cottrell LF, Carpenter HC, Sim AT, Verrills NM, 'Protein phosphatase 2A carboxymethylation and regulatory B subunits differentially regulate mast cell degranulation', FEBS Journal, Prague, Czech Republic (2009) [E3]

Co-authors: Nikki Verrills

2008Skelding KA, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Identification of CaMKII binding proteins in brain sensitive to CaMKII phosphorylation state', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
2008Skelding KA, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Development of a novel method for the identification of CaMKII binding proteins', Journal of Neurochemistry, Shanghai, China (2008) [E3]
2007Roberts KG, Ashman LK, Sim AT, Verrills NM, 'Regulation of protein phosphatase 2A (PP2A) B subunits by Bcr/Abl: Potential targets for chronic myeloid leukemia', AACR Meeting Abstracts Online (Abstracts of the 98th AACR Annual Meeting), Los Angeles (2007) [E3]
2006Rostas JA, Migues PV, Fluechter L, Dickson PW, Sim AT, Rawoff S, et al., 'Phosphorylation of CAMKII at T253 induced by transient global ischaemia', Proceedings of the Australian Neuroscience Society, Sydney (2006) [E3]
2006Verrills NM, Carpenter HC, Sim AT, 'Disruption of Actin-containing Protein Phosphatase 2A Complexes Regulates Cell Motility in Neuroblastoma Cells', Molecular & Cellular Proteomics, California, USA (2006) [E3]

Co-authors: Nikki Verrills

2004Migues PV, Sim AT, Rostas JA, 'Changes in KCI-induced phosphorylation of AMPA and NMDA receptors during chicken brain maturation', Journal of Neurochemistry, Hong Kong (2004) [E3]

Co-authors: John Rostas

2004Rostas JA, Baldwin ML, Cammarota MP, Sim AT, 'The regulation of synaptosomal exocytosis by Src tyrosine kinases', Journal of Neurochemistry, Hong Kong (2004) [E3]

Co-authors: John Rostas

Show 7 more
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Grants and Funding

Summary

Number of grants77
Total funding$8,217,601

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2008 (2 grants)

PP2A: a novel target for leukaemia therapy$300,000
Funding Body: Cancer Council NSW

Project Team
Doctor Nikki Verrills, Conjoint Professor Leonie Ashman, Professor Alistair Sim, Associate Professor Danilo Perrotti, Assoc. Prof Timothy Hughes, Dr David Thomas
SchemeRole
Research GrantInvestigator
Total AmountFunding StartFunding Finish
$300,00020082010
GNo:G0187694

PP2A: A new target for asthma therapy$20,000
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim, Doctor Nikki Verrills, Professor John Scott, Conjoint Professor Peter Wark
SchemeRole
Near Miss GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020082008
GNo:G0188395

2007 (6 grants)

Functional Characterisation of a New Regulatory Mechanism for CaMKII at Synapses in Vivo$526,500
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Alistair Sim
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$526,50020072009
GNo:G0186415

Heat Shock Proteins in Myometrium$437,750
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Roger Smith, Emeritus Professor Peter Dunkley, Professor Alistair Sim, Conjoint Associate Professor Andrew Bisits
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$437,75020072009
GNo:G0186406

FACSAria - Fluorescence activated cell sorter$300,000
Funding Body: Cancer Institute NSW

Project Team
Doctor Nikki Verrills, Conjoint Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
SchemeRole
Infrastructure GrantsInvestigator
Total AmountFunding StartFunding Finish
$300,00020072007
GNo:G0187666

HMRI Contribution toward FACSAria - Fluorescence activated cell sorter$52,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Nikki Verrills, Conjoint Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$52,00020072007
GNo:G0188207

Differential regulation of human mast cell degranulation by discrete forms of protein phosphatase 2A$50,000
Funding Body: Asthma Foundation of New South Wales

Project Team
Professor Alistair Sim, Doctor Nikki Verrills, Professor Paul Foster, Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Dr Gregory Kranias
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$50,00020072007
GNo:G0187247

Polymerase Chain Reaction (PCR) machine and Spectrophotometer$20,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Leonie Ashman, Professor Alistair Sim, Doctor Nikki Verrills
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020072007
GNo:G0188195

2006 (13 grants)

Advanced technology for transcriptomics, genomics and gene mapping$850,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Rodney Scott, Professor Ian Dawes, Professor Ronald Trent, Professor Nicholas Hunt, Emeritus Professor Peter Bergquist, Professor Mark Baker, Emeritus Professor Peter Dunkley, Dr Ruby Lin, Conjoint Professor Peter Gibson, Professor Alistair Sim
SchemeRole
Linkage Infrastructure Equipment & Facilities (LIEF)Investigator
Total AmountFunding StartFunding Finish
$850,00020062006
GNo:G0185547

PRC - Priority Research Centre for Bioinformatics, Biomarker Discovery & Information-Based Medicine (CIBM)$621,143
Funding Body: University of Newcastle

Project Team
Professor Pablo Moscato, Professor Rodney Scott, Emeritus Professor John Rostas, Professor John Forbes, Conjoint Professor Peter Hersey, Conjoint Professor Stephen Ackland, Conjoint Professor Wayne Smith, Emeritus Professor Peter Dunkley, Conjoint Professor Leonie Ashman, Professor John Attia, Associate Professor Phillip Dickson, Associate Professor Liz Milward, Professor Alistair Sim, Associate Professor Paul Tooney, Associate Professor Regina Berretta, Conjoint Professor David Sibbritt, Conjoint Professor Chris Levi, Professor Xu Dong Zhang, Conjoint Associate Professor Patricia Crock, Conjoint Associate Professor Jeannette Lechner-Scott
SchemeRole
Priority Research CentreInvestigator
Total AmountFunding StartFunding Finish
$621,14320062013
GNo:G0186919

PRC - Priority Research Centre for Brain & Mental Health Research (CBMHR)$524,282
Funding Body: University of Newcastle

Project Team
Conjoint Professor Chris Levi, Professor Amanda Baker, Professor Mike Calford, Professor Trevor Day, Emeritus Professor Peter Dunkley, Professor Michael Hazelton, Professor Andrew Heathcote, Professor Brian Kelly, Conjoint Professor Vaughan Carr, Emeritus Professor Patricia Michie, Professor David Pow, Emeritus Professor John Rostas, Professor Ulli Schall, Professor Alistair Sim, Professor Mike Startup
SchemeRole
Priority Research CentreInvestigator
Total AmountFunding StartFunding Finish
$524,28220062013
GNo:G0186947

PRC Priority Research Centre for Asthma & Respiratory Diseases$524,282
Funding Body: University of Newcastle

Project Team
Professor Paul Foster, Conjoint Professor Peter Gibson, Conjoint Professor Kenneth Beagley, Emeritus Professor Michael Hensley, Professor Phil Hansbro, Professor Joerg Mattes, Professor Alistair Sim, Conjoint Professor Peter Wark
SchemeRole
Priority Research CentreInvestigator
Total AmountFunding StartFunding Finish
$524,28220062013
GNo:G0186914

Live cell imaging facility$149,100
Funding Body: Cancer Institute NSW

Project Team
Doctor Rick Thorne, Doctor Nikki Verrills, Professor Alistair Sim, Professor Gordon Burns
SchemeRole
Infrastructure GrantsInvestigator
Total AmountFunding StartFunding Finish
$149,10020062006
GNo:G0186146

Targeting protein phosphatases to control mast cell activation$50,000
Funding Body: Asthma Foundation of New South Wales

Project Team
Professor Alistair Sim, Professor Paul Foster
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$50,00020062006
GNo:G0186027

A novel approach to the control of mast cell activation$20,000
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim
SchemeRole
Near Miss GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020062006
GNo:G0186063

Functional Characterisation of CaMKII Phosphorylate at a New Site in vivo$20,000
Funding Body: University of Newcastle

Project Team
Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Alistair Sim
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020062006
GNo:G0186059

Identification of early-life signals induced in response to infection that predispose to asthma in later life$20,000
Funding Body: University of Newcastle

Project Team
Professor Phil Hansbro, Professor Paul Foster, Conjoint Professor Kenneth Beagley, Professor Alistair Sim
SchemeRole
Pilot GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020062006
GNo:G0186699

Novel protein phosphatase interactions in cancer$10,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Nikki Verrills, Professor Alistair Sim
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$10,00020062006
GNo:G0186480

High speed computer for a live cell imaging system$3,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Rick Thorne, Professor Gordon Burns, Doctor Nikki Verrills, Professor Alistair Sim
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$3,00020062006
GNo:G0187279

Human Proteome Organisation World Congress, Long Beach California, 28/10/2006 - 1/11/2006$2,400
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,40020062006
GNo:G0187003

BioRad Mini-PROTEAN3 Electrophoresis system$995
Funding Body: Hunter Medical Research Institute

Project Team
Conjoint Professor Leonie Ashman, Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Professor Judith Scott, Professor Alistair Sim, Doctor Nikki Verrills
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$99520062006
GNo:G0187280

2005 (5 grants)

High throughput proteomics - Thermo Finnigan ProteomeX LCQ Integrated Proteomicis Workstation$207,189
Funding Body: ARC (Australian Research Council)

Novel Substrates for High Sensitivity MALDI$14,696
Funding Body: University of Newcastle

Project Team
Professor Bruce King, Professor Alistair Sim
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$14,69620052005
GNo:G0184722

2005 RIBG allocation$14,500
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim
SchemeRole
Research Infrastructure Block Grant (RIBG)Chief Investigator
Total AmountFunding StartFunding Finish
$14,50020052005
GNo:G0185804

Regulation of Insulin Secretion by Protein Phosphatases$10,000
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$10,00020052005
GNo:G0184726

12th International Conference on Second Messengers and Phosphoproteins, 10-14 July 2005$2,500
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,50020052005
GNo:G0185611

2004 (6 grants)

Differential regulation of two modes of exocytosis by protein phosphatases$393,750
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Alistair Sim, Emeritus Professor John Rostas
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$393,75020042006
GNo:G0182930

Biacore3000-Expansion of Proteomics Facility$187,341
Funding Body: ARC (Australian Research Council)

Project Team
Professor Alistair Sim, Laureate Professor John Aitken, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Conjoint Professor Leonie Ashman, Professor Roger Smith, Professor Gordon Burns, Professor Adam McCluskey, Associate Professor Paul Tooney, Dr Fraser Ross, Conjoint Professor Ray Rose
SchemeRole
Linkage Infrastructure Equipment & Facilities (LIEF)Chief Investigator
Total AmountFunding StartFunding Finish
$187,34120042004
GNo:G0183030

Biacore3000-Expansion of Proteomics Facility$70,660
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Alistair Sim
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$70,66020042004
GNo:G0184281

Investigation of a novel molecular target for a new anti-ashtma therapy$16,000
Funding Body: Hunter Medical Research Institute

Project Team
Professor Alistair Sim
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$16,00020042004
GNo:G0183752

Regulation of the neuronal RNA binding protein, pipping by protein phosphorylation$14,500
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$14,50020042004
GNo:G0183426

12th International Conference on Second Messengers and Phosphoproteins, 3-7 August 2004$2,400
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,40020042004
GNo:G0184493

2003 (3 grants)

High Throughput 2-dimensional electrophoresis$36,443
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Alistair Sim
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$36,44320032003
GNo:G0183062

Regulation of neuronal exocytosis by protein phosphatase 2A$15,000
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$15,00020032003
GNo:G0182371

EMBO Europhosphatases 2003 Barceloa, Spain 28 June - 3 July 2003$2,400
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,40020032003
GNo:G0183232

2002 (6 grants)

Proteomic and Genomic Analysis Facility.$473,332
Funding Body: Wellcome Trust

Project Team
Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Professor Rodney Scott, Conjoint Professor Leonie Ashman
SchemeRole
Major Equipment AwardChief Investigator
Total AmountFunding StartFunding Finish
$473,33220022004
GNo:G0181527

Mechanisms of Glutamate Receptor Maturation in Chicken Brain$417,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Emeritus Professor John Rostas, Dr Martin Cammarota, Professor Alistair Sim, Conjoint Associate Professor Mick Hunter, Professor Ulli Schall
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$417,00020022004
GNo:G0180913

Peltier Thermal Cycler and associated equipment essential for establishing cDNA Retroviral Libraries$21,315
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Leonie Ashman, Dr Petranel Ferrao, Professor Gordon Burns, Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Dirk Van Helden, Dr Perry Hartfield
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$21,31520022002
GNo:G0181919

The role of Protein Phosphatase 2A in synaptic vesicle transport$13,000
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$13,00020022002
GNo:G0181407

Interaction of Protein Phosphatase 2A with the Neuron-specific RNA binding Protein, PIPPin$10,000
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim, Professor Judith Scott
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$10,00020022002
GNo:G0181406

FASEB Summer Research Conference on Protein Phosphatases, USA 13 - 19 July, 2002$2,400
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,40020022002
GNo:G0182166

2001 (5 grants)

Reciprocal Regulation of Kinases and Phosphatases in Long Term Synaptic Plasticity$15,000
Funding Body: University of Newcastle

Project Team
Emeritus Professor John Rostas, Professor Alistair Sim, Professor Robert Callister
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$15,00020012001
GNo:G0180078

Control of Catecholamine Synthesis by Tyrosine Hydroxylase.$13,000
Funding Body: University of Newcastle

Project Team
Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson, Emeritus Professor Ellak Von Nagy-Felsobuki, Professor Alistair Sim
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$13,00020012001
GNo:G0180125

Thermocycler with 96 well sample block for PCR reactions. Class II Biological Safety Cabinet. Liquid Nitrogen storage Dewar & Transport Dewar$11,770
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Emeritus Professor Peter Dunkley, Professor Alistair Sim, Professor Dirk Van Helden, Professor Robert Callister
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$11,77020012001
GNo:G0181178

Thermocycler with 96 well sample block for PCR reactions. Class II Biological Safety Cabinet. Liquid Nitrogen storage Dewar & Transport Dewar$11,770
Funding Body: University of Newcastle

Project Team
Emeritus Professor Peter Dunkley, Professor Alistair Sim, Professor Dirk Van Helden, Professor Robert Callister
SchemeRole
University/NHMRC Equipment Grant FundsInvestigator
Total AmountFunding StartFunding Finish
$11,77020012001
GNo:G0181179

EMBO Conference on Protein Phosphatases and Phosphorylation, Germany 8-12 July 2001$2,400
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,40020012001
GNo:G0181000

2000 (3 grants)

Targeting Protein Phosphatase 2A to Regulate DNA Repair.$20,000
Funding Body: Hunter Medical Research Institute

Project Team
Professor Alistair Sim
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020002001
GNo:G0180546

Secretatogue-Induced Translocation of Protein Phosphatase 2A in Mast Cells.$14,500
Funding Body: ARC (Australian Research Council)

Project Team
Professor Alistair Sim, Dr R Ludowyke
SchemeRole
Small GrantChief Investigator
Total AmountFunding StartFunding Finish
$14,50020002000
GNo:G0178966

FASEB Summer Research Conference on Protein Phosphatases, USA 23-29 July 2000$2,400
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,40020002000
GNo:G0179852

1999 (5 grants)

Targeting of Neuronal Protein Phosphatase 2A$335,505
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Alistair Sim
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$335,50519992001
GNo:G0178361

Confocal Laser Scanning Microscope Facility.$203,107
Funding Body: ARC (Australian Research Council)

Project Team
Laureate Professor John Aitken, Emeritus Professor John Patrick, Conjoint Professor Christina Offler, Associate Professor David McCurdy, Conjoint Professor Ray Rose, Doctor Tim Roberts, Conjoint Associate Professor Russell Jones, Doctor John Clulow, Emeritus Professor John Rostas, Professor Alistair Sim, Professor Gordon Burns, Conjoint Professor Loris Chahl, DR DAVID KAY
SchemeRole
Large Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$203,10719991999
GNo:G0177945

FPLC Protein Purification System$16,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Alistair Sim, Emeritus Professor John Rostas, Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$16,00019991999
GNo:G0180790

The Role of A-Kinase Anchoring Proteins in Directing the Specificity of Protein Phosphatase 1 Action in Neurons.$11,500
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$11,50019991999
GNo:G0178124

EMBO/FEBS Conference on Protein Phosphorylation and Protein De Panne, Belgium.$2,400
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,40019991999
GNo:G0180486

1998 (5 grants)

Molecular Dynamics Storm 860 Tri-mode Analysis System$35,000
Funding Body: Ramaciotti Foundations

Project Team
Professor Alistair Sim, Emeritus Professor John Rostas, Emeritus Professor Peter Dunkley, Dr Stephen Bunn, Dr Tat Cheah, Conjoint Professor Kenneth Beagley, Conjoint Professor Ray Rose, Professor Judith Scott, Doctor Cheng Chan, Professor Roger Smith
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$35,00019981998
GNo:G0177453

Control of the nervous system by protein phosphatases and anchoring prteins$19,000
Funding Body: Department of Industry, Science & Resources

Project Team
Professor Alistair Sim
SchemeRole
Bilateral S&T Program (Defunct)Chief Investigator
Total AmountFunding StartFunding Finish
$19,00019981998
GNo:G0177195

Identification of protein phosphatases acting on Tyrosine Hydroxylase in bovine adrenal chromaffin cells.$19,000
Funding Body: University of Newcastle

Project Team
Emeritus Professor Peter Dunkley, Professor Alistair Sim, Dr Tat Cheah
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$19,00019981998
GNo:G0177219

The Role of Protein Phosphatases in Allergic Response Mast Cell Secretion$16,486
Funding Body: Asthma Foundation of New South Wales

Project Team
Professor Alistair Sim
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$16,48619981999
GNo:G0177600

Characterisation of Neuronal Protein Phosphatase 1 Binding Proteins.$11,500
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$11,50019981998
GNo:G0177262

1997 (5 grants)

Role of Protein Phosphorylation in the Control of Glutamate Release from Nerve Terminals.$178,409
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Emeritus Professor Peter Dunkley, Dr B Walmsley, Professor Alistair Sim, Dr Stephen Bunn
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$178,40919971999
GNo:G0176252

Characteristation of Novel Molecular Probes for Protein Phosphatases.$160,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Alistair Sim, Emeritus Professor John Rostas, Dr R Capon
SchemeRole
Large GrantChief Investigator
Total AmountFunding StartFunding Finish
$160,00019971999
GNo:G0176188

Modulation of Neurotransmitted Release by Carboxyl-methylation and tyrosine Phosphorylation of Protein Phosphatase type 2A.$18,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Alistair Sim, Doctor Paul Brent, Emeritus Professor Peter Dunkley
SchemeRole
Small GrantChief Investigator
Total AmountFunding StartFunding Finish
$18,00019971997
GNo:G0176731

Molecular Characterisation of Protein Phosphatase 2A.$8,500
Funding Body: Ian Potter Foundation

Project Team
Professor Alistair Sim
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$8,50019971997
GNo:G0176967

Joint Meeting of the International and American Societies for Neurochemistry, Boston, USA, 20-26 July 1997$2,500
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,50019971997
GNo:G0179567

1996 (3 grants)

Molecular characterisation of cytoskeletal protein phosphatase 2A$60,662
Funding Body: ARC (Australian Research Council)

Project Team
Professor Alistair Sim
SchemeRole
Multi-Year Small Grant ScholarshipChief Investigator
Total AmountFunding StartFunding Finish
$60,66219961999
GNo:G0175745

Purchase Shaking Incubator and Peltier Thermocycler$10,000
Funding Body: Ian Potter Foundation

Project Team
Professor Alistair Sim
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$10,00019961996
GNo:G0176056

Federation of American Societies for Experimental Biology, Colorado, USA, 21-26 July 1996$2,400
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,40019961996
GNo:G0176477

1995 (4 grants)

Regulation of neuronal protein phosphatases types 1 & 2A.$218,471
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Alistair Sim
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$218,47119951997
GNo:G0174526

95APP. High resolution purification of intra-cellular signalling proteins from brain by FPLC.$20,000
Funding Body: Ramaciotti Foundations

Project Team
Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00019951995
GNo:G0174696

Phosphorylation of glycoprotein GP-180:- Implications for NMDA-type glutamate receptor function$9,000
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim, Emeritus Professor John Rostas
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$9,00019951995
GNo:G0174918

Intern. Society for Neurochemistry, Japan, 2-7 July$2,400
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,40019951995
GNo:G0176855

1994 (2 grants)

The control of tyrosine hydroxylase activity by protein phosphorylation.$6,000
Funding Body: University of Newcastle

Project Team
Emeritus Professor Peter Dunkley, Dr Stephen Bunn, Professor Alistair Sim
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$6,00019941994
GNo:G0174737

Do sigma binding site ligands modulate neurotransmission by molecular mechanisms involving protein phosphorylation in neuronal tissue$5,000
Funding Body: University of Newcastle

Project Team
Doctor Paul Brent, Emeritus Professor Peter Dunkley, Professor Alistair Sim
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$5,00019941994
GNo:G0174732

1993 (2 grants)

Advance Warning Of Cyanobacterial Activity$119,637
Funding Body: Urban Water Research Association

Project Team
Professor Alistair Sim, Emeritus Professor John Rostas
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$119,63719931994
GNo:G0173334

'ISN Bien. Meet',Montpellier-22 - 27 Aug.93,'European Protein Phosphatase Meeting'Bressanone,19-23 Sept 1993,'1st Int. Symp.on Cyanobacteria,Bath,27-29Sept$2,400
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,40019931993
GNo:G0174350

1992 (2 grants)

92,93,94GRANT. The Regulation Of Protein Phosphatases In The Brain$183,006
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$183,00619921994
GNo:G0174274

Characterisation Of Novel Inhibitions And Activators Of Protein Phosphatases And Protein Kinases Isolated From Australian Marine Invertebrates.$25,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Alistair Sim
SchemeRole
Small GrantChief Investigator
Total AmountFunding StartFunding Finish
$25,00019921992
GNo:G0173619
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Research Supervision

Number of current supervisions0

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Past Supervision

YearProgramSupervisor TypeResearch Title
2012PhD (Medical Biochemistry)Co-SupervisorThe Role of Protein Phosphatase 2A as a Tumour Suppressor in Breast Cancer
2011PhD (Medical Biochemistry)Co-SupervisorRegulation of Mast Cell Degranulation by Protein Phosphatase 2A
2010PhD (Medical Biochemistry)Co-SupervisorRegulation of the Tumour Suppressor PP2A by Oncogenic Tyrosine Kinases
2004PhD (Medical Biochemistry)Sole SupervisorYeast Two-Hybrid Analysis of Protein Phosphatase 2A Binding Proteins
2004PhD (Medical Biochemistry)Principal SupervisorDifferential Regulation of Two Modes of Synaptic Vesicle Exocytosis by Protein Phosphorylation
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Professor Alistair Sim

Email
PositionConjoint Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaMedical Biochemistry
URL:www.newcastle.edu.au/profile/alistair-sim
Linkhttp://www.newcastle.edu.au/school/biomedical-science/staff/AlistairSim.html