2023 |
Kluge MG, Maltby S, Kuhne C, Walker N, Bennett N, Aidman E, et al., 'Erratum: Correction: Evaluation of a Virtual Reality Platform to Train Stress Management Skills for a Defense Workforce: Multisite, Mixed Methods Feasibility Study (Journal of medical Internet research (2023) 25 (e46368))', Journal of medical Internet research, 25 e54504 (2023)
[This corrects the article DOI: 10.2196/46368.].... [more]
[This corrects the article DOI: 10.2196/46368.].
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2023 |
Kluge MG, Maltby S, Kuhne C, Walker N, Bennett N, Aidman E, et al., 'Correction: Evaluation of a Virtual Reality Platform to Train Stress Management Skills for a Defense Workforce: Multisite, Mixed Methods Feasibility Study (Preprint) (2023)
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2023 |
Kluge MG, Maltby S, Kuhne C, Walker N, Bennett N, Aidman E, et al., 'Evaluation of a Virtual Reality Platform to Train Stress Management Skills for a Defense Workforce: Multisite, Mixed Methods Feasibility Study.', J Med Internet Res, 25 e46368 (2023) [C1]
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Nova |
2023 |
Albertella L, Kirkham R, Adler AB, Crampton J, Drummond SPA, Fogarty GJ, et al., 'Building a transdisciplinary expert consensus on the cognitive drivers of performance under pressure: An international multi-panel Delphi study', Frontiers in Psychology, 13 (2023) [C1]
Introduction: The ability to perform optimally under pressure is critical across many occupations, including the military, first responders, and competitive sport. Despite recogni... [more]
Introduction: The ability to perform optimally under pressure is critical across many occupations, including the military, first responders, and competitive sport. Despite recognition that such performance depends on a range of cognitive factors, how common these factors are across performance domains remains unclear. The current study sought to integrate existing knowledge in the performance field in the form of a transdisciplinary expert consensus on the cognitive mechanisms that underlie performance under pressure. Methods: International experts were recruited from four performance domains [(i) Defense; (ii) Competitive Sport; (iii) Civilian High-stakes; and (iv) Performance Neuroscience]. Experts rated constructs from the Research Domain Criteria (RDoC) framework (and several expert-suggested constructs) across successive rounds, until all constructs reached consensus for inclusion or were eliminated. Finally, included constructs were ranked for their relative importance. Results: Sixty-eight experts completed the first Delphi round, with 94% of experts retained by the end of the Delphi process. The following 10 constructs reached consensus across all four panels (in order of overall ranking): (1) Attention; (2) Cognitive Control¿Performance Monitoring; (3) Arousal and Regulatory Systems¿Arousal; (4) Cognitive Control¿Goal Selection, Updating, Representation, and Maintenance; (5) Cognitive Control¿Response Selection and Inhibition/Suppression; (6) Working memory¿Flexible Updating; (7) Working memory¿Active Maintenance; (8) Perception and Understanding of Self¿Self-knowledge; (9) Working memory¿Interference Control, and (10) Expert-suggested¿Shifting. Discussion: Our results identify a set of transdisciplinary neuroscience-informed constructs, validated through expert consensus. This expert consensus is critical to standardizing cognitive assessment and informing mechanism-targeted interventions in the broader field of human performance optimization.
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2022 |
Kluge MG, Maltby S, Keynes A, Nalivaiko E, Evans DJR, Walker FR, 'Current State and General Perceptions of the Use of Extended Reality (XR) Technology at the University of Newcastle: Interviews and Surveys From Staff and Students', SAGE OPEN, 12 (2022) [C1]
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Nova |
2022 |
John AR, Singh AK, Do T-TN, Eidels A, Nalivaiko E, Gavgani AM, et al., 'Unraveling the Physiological Correlates of Mental Workload Variations in Tracking and Collision Prediction Tasks', IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING, 30 770-781 (2022) [C1]
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Nova |
2021 |
Hood RJ, Maltby S, Keynes A, Kluge MG, Nalivaiko E, Ryan A, et al., 'Development and Pilot Implementation of TACTICS VR: A Virtual Reality-Based Stroke Management Workflow Training Application and Training Framework', FRONTIERS IN NEUROLOGY, 12 (2021) [C1]
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Nova |
2021 |
Kluge MG, Maltby S, Walker N, Bennett N, Aidman E, Nalivaiko E, Walker FR, 'Development of a modular stress management platform (Performance Edge VR) and a pilot efficacy trial of a bio-feedback enhanced training module for controlled breathing', PLoS ONE, 16 (2021) [C1]
This paper describes the conceptual design of a virtual reality-based stress management training tool and evaluation of the initial prototype in a pilot efficacy study. Performanc... [more]
This paper describes the conceptual design of a virtual reality-based stress management training tool and evaluation of the initial prototype in a pilot efficacy study. Performance Edge virtual-reality (VR) was co-developed with the Australian Defence Force (ADF) to address the need for practical stress management training for ADF personnel. The VR application is biofeedback-enabled and contains key stress management techniques derived from acceptance and commitment and cognitive behavioural therapy in a modular framework. End-user-provided feedback on usability, design, and user experience was positive, and particularly complimentary of the respiratory biofeedback functionality. Training of controlled breathing delivered across 3 sessions increased participants¿ self-reported use of breath control in everyday life and progressively improved controlled breathing skills (objectively assessed as a reduction in breathing rate and variability). Thus the data show that a biofeedback-enabled controlled breathing protocol delivered through Performance Edge VR can produce both behaviour change and objective improvement in breathing metrics. These results confirm the validity of Performance Edge VR platform, and its Controlled Breathing module, as a novel approach to tailoring VR-based applications to train stress management skills in a workplace setting.
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Nova |
2020 |
Bezerra-Santos CR, Bondarenko E, Essilfie AT, Nair PM, Horvat JC, Barbosa-Filho JM, et al., '
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Nova |
2019 |
Walker FR, Thomson A, Pfingst K, Vlemincx E, Aidman E, Nalivaiko E, 'Habituation of the electrodermal response - A biological correlate of resilience?', PLOS ONE, 14 (2019) [C1]
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Nova |
2019 |
Johnson PL, Molosh AI, Federici LM, Bernabe C, Haggerty D, Fitz SD, et al., 'Assessment of fear and anxiety associated behaviors, physiology and neural circuits in rats with reduced serotonin transporter (SERT) levels', TRANSLATIONAL PSYCHIATRY, 9 (2019) [C1]
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Nova |
2018 |
Gavgani AM, Wong RHX, Howe PRC, Hodgson DM, Walker FR, Nalivaiko E, 'Cybersickness-related changes in brain hemodynamics: A pilot study comparing transcranial Doppler and near-infrared spectroscopy assessments during a virtual ride on a roller coaster.', Physiol Behav, 191 56-64 (2018) [C1]
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Nova |
2018 |
Mendonca MM, Santana JS, da Cruz KR, Ianzer D, Ghedini PC, Nalivaiko E, et al., 'Involvement of GABAergic and Adrenergic Neurotransmissions on Paraventricular Nucleus of Hypothalamus in the Control of Cardiac Function', FRONTIERS IN PHYSIOLOGY, 9 (2018) [C1]
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Nova |
2018 |
Gavgani AM, Walker FR, Hodgson DM, Nalivaiko E, 'A comparative study of cybersickness during exposure to virtual reality and classic motion sickness: Are they different?', Journal of Applied Physiology, 125 1670-1680 (2018) [C1]
Existing evidence suggests that cybersickness may be clinically different from ¿classic,¿ motion-induced sickness; this evidence was, however, obtained in separate studies that fo... [more]
Existing evidence suggests that cybersickness may be clinically different from ¿classic,¿ motion-induced sickness; this evidence was, however, obtained in separate studies that focused on just one of the two conditions. Our aim was to bring clarity to this issue by directly comparing subjective symptoms and physiological effects of motion sickness induced by physical motion (Coriolis cross-coupling) and by immersion in virtual reality (ride on a roller coaster) in the same subjects. A cohort of 30 young, healthy volunteers was exposed to both stimulations in a counterbalanced order on 2 separate days =1 wk apart. Nausea scores were recorded during the exposure, and the Motion Sickness Assessment Questionnaire (MSAQ) was used to profile subjective symptoms postexperiment. Tonic and phasic forehead skin conductance level (SCL) was measured before and during exposure in both stimulation methods. We found that the nausea onset times were significantly correlated in both tests (r 0.40, P 0.03). Similarly, the maximum nausea ratings were significantly correlated during both provocations (r 0.58, P 0.0012). Symptom-profiling with the MSAQ revealed substantial and significant correlations between total symptom scores (r 0.69, P < 0.0001) between each of 4 symptom clusters and between 15/18 individual symptoms assessed in both conditions. Both virtual reality and Coriolis cross-coupling provocations caused an increase in tonic SCL associated with nausea [mean difference (mean diff) 5.1, confidence interval (CI) (2.59, 6.97), P 0.007 and mean diff 1.49, CI (0.47, 7.08), P 0.0001, respectively], with a close correlation between the conditions (r 0.48, P 0.04). This was accompanied by a significant increase in the amplitude of phasic skin conductance transients in both visual stimulation and Coriolis cross-coupling when participants reported maximum nausea compared with no nausea [mean diff 0.27, CI (0.091, 0.63), P < 0.001 and mean diff 0.235, CI (0.053, 0.851), P < 0.006, respectively]. We conclude that symptoms and physiological changes occurring during cybersickness and classic motion sickness are quite similar, at least during advanced stages of these malaises.
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Nova |
2017 |
Asadi H, Mohamed S, Lim CP, Nahavandi S, Nalivaiko E, 'Semicircular canal modeling in human perception', Reviews in the Neurosciences, 28 537-549 (2017) [C1]
The human vestibular system is a sensory and equilibrium system that manages and controls the human sense of balance and movement. It is the main sensor humans use to perceive rot... [more]
The human vestibular system is a sensory and equilibrium system that manages and controls the human sense of balance and movement. It is the main sensor humans use to perceive rotational and linear motions. Determining an accurate mathematical model of the human vestibular system is significant for research pertaining to motion perception, as the quality and effectiveness of the motion cueing algorithm (MCA) directly depends on the mathematical model used in its design. This paper describes the history and analyses the development process of mathematical semicircular canal models. The aim of this review is to determine the most consistent and reliable mathematical semicircular canal models that agree with experimental results and theoretical analyses, and offer reliable approximations for the semicircular canal functions based on the existing studies. Selecting and formulating accurate mathematical models of semicircular canals are essential for implementation into the MCA and for ensuring effective human motion perception modeling.
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Nova |
2017 |
Gavgani AM, Nesbitt KV, Blackmore KL, Nalivaiko E, 'Profiling subjective symptoms and autonomic changes associated with cybersickness', Autonomic Neuroscience, 203 41-50 (2017) [C1]
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Nova |
2017 |
Gavgani AM, Hodgson DM, Nalivaiko E, 'Effects of visual flow direction on signs and symptoms of cybersickness', PLOS ONE, 12 (2017) [C1]
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Nova |
2017 |
Romano F, Caramia N, Straumann D, Nalivaiko E, Bertolini G, 'Cross-coupling vestibular stimulation: motion sickness and the vestibulo-sympathetic reflex', Journal of Neurology, 264 96-103 (2017) [C1]
Motion sickness is associated with a variety of autonomic symptoms, presumably due to proximity or functional interconnectivity between the autonomic centers in the brainstem and ... [more]
Motion sickness is associated with a variety of autonomic symptoms, presumably due to proximity or functional interconnectivity between the autonomic centers in the brainstem and the vestibular system. A direct influence of the vestibular system on cardiovascular variables, defined as the vestibulo-sympathetic reflex, has been reported previously. Our aim was to investigate the sudomotor components of the autonomic responses associated with motion sickness during passive cross-coupling stimulation (¿roll while rotating¿). Healthy subjects (n¿=¿17) were rotated at 40°/s around an earth-vertical yaw axis alone and in combination with sinusoidal roll oscillations (0.2¿Hz). Motion sickness was assessed verbally every minute using a 1¿10 scale, while recording DC and AC skin conductance levels (SCL) from the forehead. Yaw rotation alone provoked neither motion sickness nor variations of forehead sweating. Yet during cross-coupling stimulation all subjects reported motion sickness. Higher motion sickness scores (>5) were associated with significantly higher amplitudes of AC-SCL events compared to the lower scores (0.22¿±¿0.01 vs. 0.11¿±¿0.01¿µS, respectively). Frequency domain analysis of the AC-SCL events revealed a peak at 0.2¿Hz, coinciding with the frequency of the chair rolls. The total power of AC-SCL signals did not match the trend of motion sickness scores across conditions. We conclude that: (1) although SCL is related to motion sickness, it does not follow the perceived sickness closely; (2) the discrepancy between SCL and motion sickness and the rhythmic AC-SCL events could reflect a sudomotor component of the vestibulo-sympathetic reflex.
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Nova |
2017 |
Carnevali L, Rivara S, Nalivaiko E, Thayer JF, Vacondio F, Mor M, Sgoifo A, 'Pharmacological inhibition of FAAH activity in rodents: A promising pharmacological approach for psychological cardiac comorbidity?', Neuroscience and Biobehavioral Reviews, 74 444-452 (2017) [C1]
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Nova |
2017 |
Tu L, Poppi L, Rudd J, Cresswell ET, Smith DW, Brichta A, Nalivaiko E, 'Alpha-9 nicotinic acetylcholine receptors mediate hypothermic responses elicited by provocative motion in mice', Physiology and Behavior, 174 114-119 (2017) [C1]
Hypothermic responses accompany motion sickness in humans and can be elicited by provocative motion in rats. We aimed to determine the potential role in these responses of the eff... [more]
Hypothermic responses accompany motion sickness in humans and can be elicited by provocative motion in rats. We aimed to determine the potential role in these responses of the efferent cholinergic vestibular innervation. To this end, we used knockout (KO) mice lacking a9 cholinoreceptor subunit predominantly expressed in the vestibular hair cells and CBA strain as a wild-type (WT) control. In WT mice, circular horizontal motion (1¿Hz, 4¿cm radius, 20¿min) caused rapid and dramatic falls in core body temperature and surface head temperature associated with a transient rise in the tail temperature; these responses were substantially attenuated in KO mice; changes were (WT vs. KO): for the core body temperature¿-¿5.2¿±¿0.3 vs. -¿2.9¿±¿0.3¿°C; for the head skin temperature¿-¿3.3¿±¿0.2 vs. -¿1.7¿±¿0.2¿°C; for the tail skin temperature¿+¿3.9¿±¿1.1 vs¿+¿1.1¿±¿1.2¿°C. There was a close correlation in the time course of cooling the body and the surface of the head. KO mice also required 25% more time to complete a balance test. We conclude: i) that the integrity of cholinergic efferent vestibular system is essential for the full expression of motion-induced hypothermia in mice, and that the role of this system is likely facilitatory; ii) that the system is involvement in control of balance, but the involvement is not major; iii) that in mice, motion-induced body cooling is mediated via increased heat flow through vasodilated tail vasculature and (likely) via reduced thermogenesis. Our results support the idea that hypothermia is a biological correlate of a nausea-like state in animals.
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Nova |
2017 |
Walker FR, Pfingst K, Carnevali L, Sgoifo A, Nalivaiko E, 'In the search for integrative biomarker of resilience to psychological stress', Neuroscience and Biobehavioral Reviews, 74 310-320 (2017) [C1]
Psychological resilience can be defined as individual's ability to withstand and adapt to adverse and traumatic events. Resilience is traditionally assessed by subjective rep... [more]
Psychological resilience can be defined as individual's ability to withstand and adapt to adverse and traumatic events. Resilience is traditionally assessed by subjective reports, a method that is susceptible to self-report bias. An ideal solution to this challenge is the introduction of standardised and validated physiological and/or biological predictors of resilience. We provide a summary of the major concepts in the field of resilience followed by a detailed critical review of the literature around physiological, neurochemical and immune markers of resilience. We conclude that in future experimental protocols, biological markers of resilience should be assesses both during baseline and during laboratory stressors. In the former case the most promising candidates are represented by heart rate variability and by in vitro immune cells assay; in the latter case¿by startle responses (especially their habituation) during stress challenge and by cardiovascular recovery after stress, and by cortisol, DHEA and cytokine responses. Importantly, they should be used in combination to enhance predictive power.
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Nova |
2017 |
Tu L, Lu Z, Dieser K, Schmitt C, Chan SW, Ngan MP, et al., 'Brain Activation by H-1 Antihistamines Challenges Conventional View of Their Mechanism of Action in Motion Sickness: A Behavioral, c-Fos and Physiological Study in Suncus murinus (House Musk Shrew)', FRONTIERS IN PHYSIOLOGY, 8 (2017) [C1]
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Nova |
2017 |
Nesbitt K, Davis S, Blackmore K, Nalivaiko E, 'Correlating Reaction Time and Nausea Measures with Traditional Measures of Cybersickness', Displays, 48 1-8 (2017) [C1]
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Nova |
2017 |
Carreiro JN, Magnani M, Jobling P, van Helden DF, Nalivaiko E, Braga VA, 'Resveratrol restores uterine contractions during hypoxia by blockade of ATP-sensitive potassium channels', Journal of Functional Foods, 33 307-313 (2017) [C1]
This study assessed the¿effects of resveratrol, a polyphenol¿found in grapes and red wine¿on non-pregnant murine uteri under hypoxia. Resveratrol at 1, 3, 10, 30 and 100¿µM promot... [more]
This study assessed the¿effects of resveratrol, a polyphenol¿found in grapes and red wine¿on non-pregnant murine uteri under hypoxia. Resveratrol at 1, 3, 10, 30 and 100¿µM promoted uterine relaxation and decreased the amplitude and frequency of spontaneous uterine contractions. Assayed at 3, 10, 30¿µM, resveratrol inhibited the oxytocin-induced cumulative contractions reducing the maximum effect in a dose-dependent manner. In hypoxic uteri, resveratrol at 100¿µM restored the uterine contractions compromised by hypoxia. In addition, under hypoxia, resveratrol prevented the decrease in uterine contractions maintaining >75% of its contraction capability. The effects of resveratrol on uterine contractions under hypoxia were attenuated by tetraethylammonium (10¿mM) and almost abolished by glibenclamide (10¿µM). Our¿results show regenerative and protective effects of resveratrol in non-pregnant murine uteri under hypoxia and describes for the first time that these effects are mediated by blockade of ATP-sensitive potassium channels.
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Nova |
2016 |
Mündel T, Nalivaiko E, Kent S, Maloney SK, Vetter I, 'How hot is it Down Under?', Temperature, 3 355-357 (2016)
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2016 |
Monteiro TM, Costa HF, Vieira GC, Rodrigues Salgado PR, da Silva Stiebbe Salvadori MG, de Almeida RN, et al., 'Anti-asthmatic and anxiolytic effects of Herissantia tiubae, a Brazilian medicinal plant', IMMUNITY INFLAMMATION AND DISEASE, 4 201-212 (2016) [C1]
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Nova |
2016 |
Carnevali L, Andrews PL, Neumann ID, Nalivaiko E, Sgoifo A, 'Autonomic changes induced by provocative motion in rats bred for high (HAB) and low (LAB) anxiety-related behavior: Paradoxical responses in LAB animals.', Physiology and Behavior, 167 363-373 (2016) [C1]
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Nova |
2016 |
Bondarenko E, Guimarães DD, Braga VA, Nalivaiko E, 'Integrity of the dorsolateral periaqueductal grey is essential for the fight-or-flight response, but not the respiratory component of a defense reaction', Respiratory Physiology and Neurobiology, 226 94-101 (2016) [C1]
Periaqueductal grey is believed to be one of the key structures of the central respiratory stress network. Previous studies established that stimulation of the periaqueductal grey... [more]
Periaqueductal grey is believed to be one of the key structures of the central respiratory stress network. Previous studies established that stimulation of the periaqueductal grey, especially its dorsolateral division (dlPAG), evokes tachypnea as well as increases in other autonomic parameters and motor activity. We investigated the effects of blockade of the dlPAG with GABAA agonist muscimol on respiration during stress and presentation of brief alerting stimuli in conscious unrestrained rats. We found that integrity of the dlPAG is not essential for stress-induced increase in basal/resting respiratory rate or for generation of respiratory responses to brief alerting stimuli. However, blockade of the dlPAG reduced the amount of motor activity and concomitant high-frequency respiratory activity during restraint and the first 5 min of novelty stress. We conclude that the integrity of the dlPAG is not essential for generation of respiratory component of the defense reaction, but it mediates expression of the fight-or-flight response including its respiratory component.
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Nova |
2015 |
Nalivaiko E, Davis SL, Blackmore KL, Vakulin A, Nesbitt KV, 'Cybersickness provoked by head-mounted display affects cutaneous vascular tone, heart rate and reaction time', Physiology and Behavior, 151 583-590 (2015) [C1]
Evidence from studies of provocative motion indicates that motion sickness is tightly linked to the disturbances of thermoregulation. The major aim of the current study was to det... [more]
Evidence from studies of provocative motion indicates that motion sickness is tightly linked to the disturbances of thermoregulation. The major aim of the current study was to determine whether provocative visual stimuli (immersion into the virtual reality simulating rides on a rollercoaster) affect skin temperature that reflects thermoregulatory cutaneous responses, and to test whether such stimuli alter cognitive functions. In 26 healthy young volunteers wearing head-mounted display (Oculus Rift), simulated rides consistently provoked vection and nausea, with a significant difference between the two versions of simulation software (Parrot Coaster and Helix). Basal finger temperature had bimodal distribution, with low-temperature group (n. =. 8) having values of 23-29. °C, and high-temperature group (n. =. 18) having values of 32-36. °C. Effects of cybersickness on finger temperature depended on the basal level of this variable: in subjects from former group it raised by 3-4. °C, while in most subjects from the latter group it either did not change or transiently reduced by 1.5-2. °C. There was no correlation between the magnitude of changes in the finger temperature and nausea score at the end of simulated ride. Provocative visual stimulation caused prolongation of simple reaction time by 20-50. ms; this increase closely correlated with the subjective rating of nausea. Lastly, in subjects who experienced pronounced nausea, heart rate was elevated. We conclude that cybersickness is associated with changes in cutaneous thermoregulatory vascular tone; this further supports the idea of a tight link between motion sickness and thermoregulation. Cybersickness-induced prolongation of reaction time raises obvious concerns regarding the safety of this technology.
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Nova |
2015 |
Baumert M, Pamula Y, Kohler M, Martin J, Kennedy D, Nalivaiko E, Immanuel SA, 'Effect of respiration on heartbeat-evoked potentials during sleep in children with sleep-disordered breathing', Sleep Medicine, (2015) [C1]
Objective: Heartbeat-evoked potentials (HEPs) in electroencephalogram (EEG) provide a quantitative measure of cardiac interoception during sleep. We previously reported reduced HE... [more]
Objective: Heartbeat-evoked potentials (HEPs) in electroencephalogram (EEG) provide a quantitative measure of cardiac interoception during sleep. We previously reported reduced HEPs in children with sleep-disordered breathing (SDB), indicative of attenuated cardiac information processing. The objective of this study was to investigate the link between HEP and respiration. Patients/Methods: From the overnight polysomnograms of 40 healthy children and 40 children with SDB, we measured HEPs during epochs of stage 2, slow-wave and rapid eye movement (REM) sleep free of abnormal respiratory events. HEPs were analysed with respect to respiratory phase. Results: We observed a marked association between respiratory phase and HEP in children with SDB during REM sleep, but not in normal children. In children with SDB, HEP waveforms were attenuated during expiration compared to inspiration. Following adenotonsillectomy, expiratory HEP peak amplitude increased in the SDB children and was no longer different from those of normal children. Conclusions: The expiratory phase of respiration is primarily associated with attenuated cardiac information processing in children with SDB, establishing a pathophysiological link between breathing and HEP attenuation.
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Nova |
2015 |
Bondarenko E, Beig MI, Hodgson DM, Braga VA, Nalivaiko E, 'Blockade of the dorsomedial hypothalamus and the perifornical area inhibits respiratory responses to arousing and stressful stimuli.', Am J Physiol Regul Integr Comp Physiol, 308 R816-R822 (2015) [C1]
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Nova |
2015 |
Silva NT, Nalivaiko E, da Silva LG, Haibara AS, 'Excitatory amino acid receptors in the dorsomedial hypothalamic area contribute to the chemoreflex tachypneic response', RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 212 1-8 (2015) [C1]
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Nova |
2015 |
Rudd JA, Nalivaiko E, Matsuki N, Wan C, Andrews PL, 'The involvement of TRPV1 in emesis and anti-emesis.', Temperature (Austin), 2 258-276 (2015) [C1]
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Nova |
2015 |
Guimaraes DD, Andrews PLR, Rudd JA, Braga VA, Nalivaiko E, 'Ondansetron and promethazine have differential effects on hypothermic responses to lithium chloride administration and to provocative motion in rats.', Temperature (Austin), 2 543-553 (2015) [C1]
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Nova |
2014 |
Ngampramuan S, Cerri M, del Vecchio F, Corrigan JJ, Kamphee A, Dragic AS, et al., 'Thermoregulatory correlates of nausea in rats and musk shrews', Oncotarget, 5 1565-1575 (2014) [C1]
Nausea is a prominent symptom and major cause of complaint for patients receiving anticancer chemo- or radiation therapy. The arsenal of anti-nausea drugs is limited, and their ef... [more]
Nausea is a prominent symptom and major cause of complaint for patients receiving anticancer chemo- or radiation therapy. The arsenal of anti-nausea drugs is limited, and their efficacy is questionable. Currently, the development of new compounds with anti-nausea activity is hampered by the lack of physiological correlates of nausea. Physiological correlates are needed because common laboratory rodents lack the vomiting reflex. Furthermore, nausea does not always lead to vomiting. Here, we report the results of studies conducted in four research centers to investigate whether nausea is associated with any specific thermoregulatory symptoms. Two species were studied: the laboratory rat, which has no vomiting reflex, and the house musk shrew (Suncus murinus), which does have a vomiting reflex. In rats, motion sickness was induced by rotating them in their individual cages in the horizontal plane (0.75 Hz, 40 min) and confirmed by reduced food consumption at the onset of dark (active) phase. In 100% of rats tested at three centers, postrotational sickness was associated with marked (~1.5°C) hypothermia, which was associated with a short-lasting tail-skin vasodilation (skin temperature increased by ~4°C). Pretreatment with ondansetron, a serotonin 5-HT3 receptor antagonist, which is used to treat nausea in patients in chemo- or radiation therapy, attenuated hypothermia by ~30%. In shrews, motion sickness was induced by a cyclical backand-forth motion (4 cm, 1 Hz, 15 min) and confirmed by the presence of retching and vomiting. In this model, sickness was also accompanied by marked hypothermia (~2°C). Like in rats, the hypothermic response was preceded by transient tail-skin vasodilation. In conclusion, motion sickness is accompanied by hypothermia that involves both autonomic and thermoeffector mechanisms: tail-skin vasodilation and possibly reduction of the interscapular brown adipose tissue activity. These thermoregulatory symptoms may serve as physiological correlates of nausea.
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Nova |
2014 |
Xavier CH, Ianzer D, Lima AM, Marins FR, Pedrino GR, Vaz G, et al., 'Excitatory amino acid receptors mediate asymmetry and lateralization in the descending cardiovascular pathways from the dorsomedial hypothalamus', PLoS ONE, 9 (2014) [C1]
The dorsomedial hypothalamus (DMH) and lateral/dorsolateral periaqueductal gray (PAG) are anatomically and functionally connected. Both the DMH and PAG depend on glutamatergic inp... [more]
The dorsomedial hypothalamus (DMH) and lateral/dorsolateral periaqueductal gray (PAG) are anatomically and functionally connected. Both the DMH and PAG depend on glutamatergic inputs for activation. We recently reported that removal of GABA-ergic tone in the unilateral DMH produces: asymmetry, that is, a right- (R-) sided predominance in cardiac chronotropism, and lateralization, that is, a greater increase in ipsilateral renal sympathetic activity (RSNA). In the current study, we investigated whether excitatory amino acid (EAA) receptors in the DMH-PAG pathway contribute to the functional interhemispheric difference. In urethane (1.2 to 1.4 g/kg, i.p.) anesthetized rats, we observed that: (i) nanoinjections of N-methyl D-aspartate (NMDA 100 pmol/100 nl) into the unilateral DMH produced the same right-sided predominance in the control of cardiac chronotropy, (ii) nanoinjections of NMDA into the ipsilateral DMH or PAG evoked lateralized RSNA responses, and (iii) blockade of EAA receptors in the unilateral DMH attenuated the cardiovascular responses evoked by injection of NMDA into either the R- or left- (L-) PAG. In awake rats, nanoinjection of kynurenic acid (1 nmol/100 nL) into the L-DMH or R- or L-PAG attenuated the tachycardia evoked by air stress. However, the magnitude of stress-evoked tachycardia was smallest when the EAA receptors of the R-DMH were blocked. We conclude that EAA receptors contribute to the right-sided predominance in cardiac chronotropism. This interhemispheric difference that involves EAA receptors was observed in the DMH but not in the PAG.
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Nova |
2014 |
Fontes MAP, Xavier CH, Marins FR, Limborço-Filho M, Vaz GC, Müller-Ribeiro FC, Nalivaiko E, 'Emotional stress and sympathetic activity: Contribution of dorsomedial hypothalamus to cardiac arrhythmias', Brain Research, 1554 49-58 (2014) [C1]
Maintenance of homeostasis in normal or stressful situations depends upon mechanisms controlling autonomic activity. Central requirement for changes in sympathetic output resultin... [more]
Maintenance of homeostasis in normal or stressful situations depends upon mechanisms controlling autonomic activity. Central requirement for changes in sympathetic output resulting from emotional stress must be adjusted to the input signals from visceral sensory afferent (feedback response) for an optimum cardiovascular performance. There is a large body of evidence indicating that emotional stress can lead to cardiovascular disease. Reviewing the descending pathways from dorsomedial hypothalamus, a key region involved in the cardiovascular response to emotional stress, we discuss the interactions between mechanisms controlling the sympathetic output to the cardiovascular system and the possible implications in cardiovascular disease. © 2014 Elsevier B.V.
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Nova |
2014 |
Del Vecchio F, Nalivaiko E, Cerri M, Luppi M, Amici R, 'Provocative motion causes fall in brain temperature and affects sleep in rats', Experimental Brain Research, 232 2591-2599 (2014) [C1]
Neural substrate of nausea is poorly understood, contrasting the wealth of knowledge about the emetic reflex. One of the reasons for this knowledge deficit is limited number and f... [more]
Neural substrate of nausea is poorly understood, contrasting the wealth of knowledge about the emetic reflex. One of the reasons for this knowledge deficit is limited number and face validity of animal models of nausea. Our aim was to search for new physiological correlates of nausea in rats. Specifically, we addressed the question whether provocative motion (40-min rotation at 0.5 Hz) affects sleep architecture, brain temperature, heart rate (HR) and arterial pressure. Six adult male Sprague-Dawley rats were instrumented for recordings of EEG, nuchal electromyographic, hypothalamic temperature and arterial pressure. Provocative motion had the following effects: (1) total abolition of REM sleep during rotation and its substantial reduction during the first hour post-rotation (from 20 ± 3 to 5 ± 1.5 %); (2) reduction in NREM sleep, both during rotation (from 57 ± 6 to 19 ± 5 %) and during the first hour post-rotation (from 56 ± 3 to 41 ± 9 %); (3) fall in the brain temperature (from 37.1 ± 0.1 to 36.0 ± 0.1°C); and (4) reduction in HR (from 375 ± 6 to 327 ± 7 bpm); arterial pressure was not affected. Ondansetron, a 5-HT3 antagonist, had no major effect on all observed parameters during both baseline and provocative motion. We conclude that in rats, provocative motion causes prolonged arousing effects, however without evidence of sympathetic activation that usually accompanies heightened arousal. Motion-induced fall in the brain temperature complements and extends our previous observations in rats and suggests that similar to humans, provocative motion triggers coordinated thermoregulatory response, leading to hypothermia in this species. © 2014 Springer-Verlag.
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Nova |
2014 |
Carnevali L, Trombini M, Graiani G, Madeddu D, Quaini F, Landgraf R, et al., 'Low vagally-mediated heart rate variability and to ventricular arrhythmias in rats bred for high increased susceptibility anxiety', PHYSIOLOGY & BEHAVIOR, 128 16-25 (2014) [C1]
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Nova |
2014 |
Immanuel SA, Pamula Y, Kohler M, Martin J, Kennedy D, Nalivaiko E, et al., 'Heartbeat Evoked Potentials during Sleep and Daytime Behavior in Children with Sleep-disordered Breathing', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 190 1149-1157 (2014) [C1]
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Nova |
2014 |
Queiroz TM, Mendes-Júnior LG, Guimarães DD, França-Silva MS, Nalivaiko E, Braga VA, 'Corrigendum to "Cardiorespiratory effects induced by 2-nitrate-1,3-dibuthoxypropan are reduced by nitric oxide scavenger in rats." [Auton. Neurosci. 181 (April 2014) 31-36]', Autonomic Neuroscience: Basic and Clinical, 185 152 (2014) [O1]
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2014 |
Queiroz TM, Mendes-Júnior LG, Guimarães DD, França-Silva MS, Nalivaiko E, Braga VA, 'Cardiorespiratory effects induced by 2-nitrate-1,3-dibuthoxypropan are reduced by nitric oxide scavenger in rats', Autonomic Neuroscience: Basic and Clinical, 181 31-36 (2014) [C1]
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Nova |
2014 |
Bondarenko E, Hodgson DM, Nalivaiko E, 'Prelimbic prefrontal cortex mediates respiratory responses to mild and potent prolonged, but not brief, stressors', RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 204 21-27 (2014) [C1]
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Nova |
2014 |
Carnevali L, Nalivaiko E, Sgoifo A, 'Respiratory patterns reflect different levels of aggressiveness and emotionality in Wild-type Groningen rats', Respiratory Physiology and Neurobiology, 204 28-35 (2014) [C1]
Respiratory patterns represent a promising physiological index for assessing emotional states in preclinical studies. Since disturbed emotional regulation may lead to forms of exc... [more]
Respiratory patterns represent a promising physiological index for assessing emotional states in preclinical studies. Since disturbed emotional regulation may lead to forms of excessive aggressiveness, in this study we investigated the hypothesis that rats that differ largely in their level of aggressive behavior display matching alterations in respiration. Respiration was recorded in male high-aggressive (HA, n=. 8) and non-aggressive (NA, n=. 8) Wild-type Groningen rats using whole-body plethysmography. Subsequently, anxiety-related behaviors were evaluated in the elevated plus maze and social avoidance-approach tests. During respiratory testing, HA rats showed elevated basal respiratory rate, reduced sniffing, exaggerated tachypnoeic response to an acoustic stimulus and a larger incidence of sighs. In addition, HA rats spent less time in the open arms of the plus maze and displayed higher levels of social avoidance behavior compared to NA rats. These findings indicate that HA rats are characterized by alterations in respiratory functioning and behavior that are overall indicative of an anxiety-like phenotype.
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Nova |
2014 |
Davenport P, Nalivaiko E, 'Introduction to Special Issue "Non-homeostatic Control of Respiration"', Respiratory Physiology and Neurobiology, 204 1-2 (2014) [C3]
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2014 |
Nalivaiko E, Rudd JA, So RH, 'Motion sickness, nausea and thermoregulation: The "toxic" hypothesis.', Temperature (Austin), 1 164-171 (2014)
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2014 |
Bondarenko E, Hodgson DM, Nalivaiko E, 'Amygdala mediates respiratory responses to sudden arousing stimuli and to restraint stress in rats.', Am J Physiol Regul Integr Comp Physiol, 306 R951-R959 (2014) [C1]
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Nova |
2013 |
Carnevali L, Trombini M, Rossi S, Graiani G, Manghi M, Koolhaas JM, et al., 'Structural and Electrical Myocardial Remodeling in a Rodent Model of Depression', PSYCHOSOMATIC MEDICINE, 75 42-51 (2013) [C1]
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Nova |
2013 |
Bobrovskaya L, Beard D, Bondarenko E, Beig MI, Jobling P, Walker FR, et al., 'Does exposure to chronic stress influence blood pressure in rats?', AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 177 217-223 (2013) [C1]
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Nova |
2013 |
Ngampramuan S, Baumert M, Czippelova B, Nalivaiko E, 'Ondansetron prevents changes in respiratory pattern provoked by LiCl: A new approach for studying pro-emetic states in rodents?', Neuroscience, 246 342-350 (2013) [C1]
There are a limited number of biological indices for assessing pro-emetic states in laboratory rodents as they do not possess the vomiting response. In the present study we tested... [more]
There are a limited number of biological indices for assessing pro-emetic states in laboratory rodents as they do not possess the vomiting response. In the present study we tested the hypothesis that in rats, pro-emetic intervention would affect the respiratory pattern. To this end, using whole-body plethysmography, in adult male Wistar rats we recorded respiration after i.p. administration of either the emetic agent LiCl or Ringer. Quantification of respiratory signals (from 5 to 35min post-injection) revealed that post-LiCl, mean respiratory rate was significantly lower (126±9 vs. 178±10cpm, p<0.005) and less variable (Kvar 59±8% vs. 73±3%; p<0.05) compared to the post-Ringer condition. Furthermore, while mode values of respiratory rate histograms did not differ between the treatments (indicating that the dominant respiratory frequency remained unchanged), LiCl reduced the fraction of time spent at high respiratory rate (>200cpm) from 25±3% to 9±2% (p=0.004). Thus, reduction of the mean respiratory rate by LiCl was predominantly due to reduced contribution of high-frequency breathing that is normally associated with motor activity and/or arousal. Non-linear multifractal analysis of respiratory signals revealed that post-LiCl, respiration becomes less random and more orderly. 5-HT3 antagonist ondansetron prevented respiratory changes elicited by LiCl. We conclude that the observed changes likely reflect effects of LiCl on animals' motion, and that this effect is mediated via 5-HT3 receptors. Providing that the effects observed in our study were quite robust, we suggest that simple and non-invasive respiratory monitoring may be a promising approach for studying emesis in rodents. © 2013 IBRO.
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Nova |
2013 |
Xavier CH, Beig MI, Ianzer D, Peliky Fontes MA, Nalivaiko E, 'Asymmetry in the control of cardiac performance by dorsomedial hypothalamus', AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 304 R664-R674 (2013) [C1]
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Nova |
2013 |
Sominsky L, Fuller EA, Bondarenko E, Ong LK, Averell L, Nalivaiko E, et al., 'Functional Programming of the Autonomic Nervous System by Early Life Immune Exposure: Implications for Anxiety', PLOS ONE, 8 (2013) [C1]
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Nova |
2013 |
Carnevali L, Sgoifo A, Trombini M, Landgraf R, Neumann ID, Nalivaiko E, 'Different Patterns of Respiration in Rat Lines Selectively Bred for High or Low Anxiety', PLOS ONE, 8 (2013) [C1]
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Nova |
2012 |
Iigaya K, Muller-Ribeiro FCDF, Horiuchi J, McDowall LM, Nalivaiko E, Fontes MAP, Dampney RAL, 'Synchronized activation of sympathetic vasomotor, cardiac, and respiratory outputs by neurons in the midbrain colliculi', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 303 R599-R610 (2012) [C1]
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Nova |
2012 |
Nalivaiko E, Bondarenko E, Lidstrom A, Barry RJ, 'Respiratory component of the orienting reflex: A novel sensitive index of sensory-induced arousal in rats', Frontiers in Physiology, 2 1-6 (2012) [C1]
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Nova |
2012 |
Carnevali L, Mastorci F, Audero E, Graiani G, Rossi S, Macchi E, et al., 'Stress-induced susceptibility to sudden cardiac death in mice with altered serotonin homeostasis', PLoS One, 7 (2012) [C1]
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Nova |
2011 |
Kabir MM, Saint DA, Nalivaiko E, Abbott D, Voss A, Baumert M, 'Quantification of cardiorespiratory interactions based on joint symbolic dynamics', Annals of Biomedical Engineering, 39 2604-2614 (2011) [C1]
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Nova |
2011 |
Kabir MM, Saint DA, Nalivaiko E, Abbott D, Baumert M, 'Time delay correction of the synchrogram for optimized detection of cardiorespiratory coordination', Medical and Biological Engineering and Computing, 49 1249-1259 (2011) [C1]
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Nova |
2011 |
Beig MI, Callister R, Saint DA, Bondarenko E, Walker FR, Day TA, Nalivaiko E, 'Voluntary exercise does not affect stress-induced tachycardia, but improves resistance to cardiac arrhythmias in rats', Clinical and Experimental Pharmacology and Physiology, 38 19-26 (2011) [C1]
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Nova |
2011 |
Nalivaiko E, 'Animal models of psychogenic cardiovascular disorders: What we can learn from them and what we cannot', Clinical and Experimental Pharmacology and Physiology, 38 115-125 (2011) [C1]
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Nova |
2011 |
Carnevali L, Bondarenko E, Sgoifo A, Walker FR, Head GA, Lukoshkova EV, et al., 'Metyrapone and fluoxetine suppress enduring behavioral but not cardiac effects of subchronic stress in rats', American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 301 R1123-R1131 (2011) [C1]
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Nova |
2011 |
Baumert M, Schlaich MP, Nalivaiko E, Lambert E, Sari CI, Kaye DM, et al., 'Relation between QT interval variability and cardiac sympathetic activity in hypertension', American Journal of Physiology - Heart and Circulatory Physiology, 300 H1412-H1417 (2011) [C1]
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Nova |
2011 |
Baumert M, Lambert E, Vaddadi G, Sari CI, Esler M, Lambert G, et al., 'Cardiac repolarization variability in patients with postural tachycardia syndrome during graded head-up tilt', Clinical Neurophysiology, 122 405-409 (2011) [C1]
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Nova |
2010 |
Kabir MM, Dimitri H, Sanders P, Antic R, Nalivaiko E, Abbott D, Baumert M, 'Cardiorespiratory phase-coupling is reduced in patients with obstructive sleep apnea', Plos One, 5 1-12 (2010) [C1]
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Nova |
2010 |
Kabir MM, Nalivaiko E, Abbott D, Baumert M, 'Impact of movement on cardiorespiratory coordination in conscious rats.', Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 1938-1941 (2010)
In this study we assessed the impact of movement on the interaction between the heart rhythm and respiration in rats while they were conscious and freely moving. In eight male adu... [more]
In this study we assessed the impact of movement on the interaction between the heart rhythm and respiration in rats while they were conscious and freely moving. In eight male adult Sprague-Dawley (SD, n=4) and Hooded Wistar (HW, n=4) rats, we recorded respiratory rate using whole-body plethysmography with a piezoelectric sensor attached to simultaneously monitor body movement. Heart rate was recorded using a radio-telemetry transmitter. For the assessment of cardiorespiratory coordination, we analysed the phase-locking between heart rate and respiration, estimating the instantaneous phases using Hilbert transform. For statistical analysis, the piezoelectric signal was dichotomized into low-intensity (LIm) and high-intensity (HIm) movement. The R-R intervals, respiratory intervals and cardiorespiratory coordination between LIm and HIm of each rat were assessed with Student's t-test. A significant decrease in the mean values for respiratory interval (0.34 ± 0.1 vs. 0.23 ± 0.1 s, p < 0.01 in HW rats) and R-R interval (0.19 ± 0.01 vs. 0.17 ± 0.01 s, p < 0.001 in SD rats) was observed during HIm. The phase-locking between the cardiac and respiratory signals also decreased significantly during HIm (overall coordination during LIm vs. HIm: 89.3 ± 3.3% vs. 8.7 ± 1.7%, p < 0.001). In conclusion the interaction between the cardiac and respiratory oscillators is affected by voluntary movements in rats.
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2010 |
Kabir MM, Beig MI, Baumert M, Trombini M, Mastorci F, Sgoifo A, et al., 'Respiratory pattern in awake rats: Effects of motor activity and of alerting stimuli', Physiology and Behavior, 101 22-31 (2010) [C1]
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Nova |
2010 |
Mackenzie LJ, Nalivaiko E, Beig MI, Day TA, Walker FR, 'Ability of predator odour exposure to elicit conditioned versus sensitised post traumatic stress disorder-like behaviours, and forebrain dFosB expression, in rats', Neuroscience, 169 733-742 (2010) [C1]
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Nova |
2010 |
Tynan R, Naicker S, Hinwood M, Nalivaiko E, Buller KM, Pow DV, et al., 'Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions', Brain Behavior and Immunity, 24 1058-1068 (2010) [C1]
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Nova |
2010 |
Baumert M, Seeck A, Faber R, Nalivaiko E, Voss A, 'Longitudinal changes in QT interval variability and rate adaptation in pregnancies with normal and abnormal uterine perfusion', Hypertension Research, 33 555-560 (2010) [C1]
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Nova |
2010 |
Nalivaiko E, Antunes VR, Paton JFR, 'Control of cardiac contractility in the rat working heart-brainstem preparation', Experimental Physiology, 95 107-119 (2010) [C1]
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Nova |
2009 |
Nalivaiko E, Mastorci F, Sgoifo A, '8-OH-DPAT prevents cardiac arrhythmias and attenuates tachycardia during social stress in rats', Physiology and Behavior, 96 320-327 (2009) [C1]
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Nova |
2009 |
Mastorci F, Vicentini M, Viltart O, Manghi M, Graiani G, Quaini F, et al., 'Long-term effects of prenatal stress: Changes in adult cardiovascular regulation and sensitivity to stress', Neuroscience & Biobehavioral Reviews, 33 191-203 (2009) [C1]
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Nova |
2009 |
Nalivaiko E, Sgoifo A, 'Central 5-HT receptors in cardiovascular control during stress', Neuroscience & Biobehavioral Reviews, 33 95-106 (2009) [C1]
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Nova |
2009 |
Beig MI, Baumert M, Walker FR, Day TA, Nalivaiko E, 'Blockade of 5-HT2A receptors suppresses hyperthermic but not cardiovascular responses to psychosocial stress in rats', Neuroscience, 159 1185-1191 (2009) [C1]
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Nova |
2009 |
Xavier CH, Nalivaiko E, Beig MI, Menezes GB, Cara DC, Campagnole-Santos MJ, Fontes MAP, 'Functional asymmetry in the descending cardiovascular pathways from dorsomedial hypothalamic nucleus', Neuroscience, 164 1360-1368 (2009) [C1]
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Nova |
2009 |
Salo LM, Nalivaiko E, Anderson CR, McAllen RM, 'Control of cardiac rate, contractility, and atrioventricular conduction by medullary raphe neurons in anesthetized rats', American Journal of Physiology-Heart and Circulatory Physiology, 296 H318-H324 (2009) [C1]
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Nova |
2009 |
Baumert M, Lambert GW, Dawood T, Lambert EA, Esler MD, McGrane M, et al., 'Short-term heart rate variability and cardiac norepinephrine spillover in patients with depression and panic disorder', American Journal of Physiology: Heart and Circulatory Physiology, 297 H674-H679 (2009) [C1]
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Nova |
2009 |
Smith JH, Baumert M, Nalivaiko E, McEvoy RD, Catcheside PG, 'Arousal in obstructive sleep apnoea patients is associated with ECG RR and QT interval shortening and PR interval lengthening', Journal of Sleep Research, 18 188-195 (2009) [C1]
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Nova |
2008 |
Baumert M, Smith J, Catcheside P, McEvoy D, Abbott D, Sanders P, Nalivaiko E, 'Variability of QT interval duration in obstructive sleep apnea: An indicator of disease severity', Sleep, 31 959-966 (2008) [C1]
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2008 |
Ngampramuan S, Baumert M, Beig MI, Kotchabhakdi N, Nalivaiko E, 'Activation of 5-HT1A receptors attenuates tachycardia induced by restraint stress in rats', American Journal of Physiology: Regulatory Integrative and Comparative Physiology, 294 R132-R141 (2008) [C1]
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2008 |
Baumert M, Lambert GW, Dawood T, Lambert EA, Esler MD, McGrane M, et al., 'QT interval variability and cardiac norepinephrine spillover in patients with depression and panic disorder', American Journal of Physiology: Heart and Circulatory Physiology, 295 962-968 (2008) [C1]
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2008 |
Oostuka Y, Blessing WW, Nalivaiko E, 'Selective blockade of 5-HT2A receptors attenuates the increased temperature response in brown adipose tissue to restraint stress in rats', Stress: the International Journal on the Biology of Stress, 11 125-133 (2008) [C1]
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2007 |
Braga VA, Zoccal DB, Soriano RN, Antunes VR, Paton JF, Machado BH, Nalivaiko E, 'Activation of peripheral chemoreceptors causes positive inotropic effects in a working heart-brainstem preparation of the rat', Clinical and Experimental Pharmacology and Physiology, 34 1156-1159 (2007) [C1]
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2007 |
Salome N, Ngampramuan S, Nalivaiko E, 'Intra-amygdala injection of GABAA agonist, muscimol, reduces tachycardia and modifies cardiac sympatho-vagal balance during restraint stress in rats', Neuroscience, 148 335-341 (2007) [C1]
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2007 |
Nalivaiko E, Catcheside PG, Adams A, Jordan AS, Eckert DJ, McEvoy RD, 'Cardiac changes during arousals from non-REM sleep in healthy volunteers', American Journal of Physiology: Regulatory Integrative and Comparative Physiology, 292 1320-1327 (2007) [C1]
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2007 |
Baumert M, Smith J, Catcheside P, McEvoy DR, Abbott D, Nalivaiko E, 'Changes in RR and QT intervals after spontaneous and respiratory arousal in patients with obstructive sleep', Computers in Cardiology, 34 670-680 (2007) [C1]
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2006 |
Nalivaiko E, 'Clinical and Experimental Pharmacology and Physiology: Introduction', Clinical and Experimental Pharmacology & Physiolog, 33 1244-1244 (2006) [C3] |
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2006 |
Paton JF, Nalivaiko E, Boscan P, Pickering AE, 'Reflexly evoked coactivation of cardiac vagal and sympathetic motor outflows: Observations and functional implications', Clinical and Experimental Pharmacology and Physiology, 33 1245-1250 (2006) [C1]
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2006 |
Nalivaiko E, '5-HT1A receptors in stress-induced cardiac changes: A possible link between mental and cardiac disorders', Clinical and Experimental Pharmacology and Physiology, 33 1259-1264 (2006) [C1]
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2006 |
Nalivaiko E, 'Tachycardia during fever: Is it neural or humoral? [1]', American Journal of Physiology: Regulatory, Integr, 290 1750-1750 (2006) [C3]
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2005 |
Paton JF, Boscan P, Pickering AE, Nalivaiko E, 'The yin and yang of cardiac autonomic control: Vago-sympathetic interactions revisited', Brain Research Reviews, 49 555-565 (2005) [C1]
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2005 |
Nalivaiko E, Oostuka Y, Blessing WW, 'Activation of 5-HT1A receptors in the medullary raphe reduces cardiovascular changes elicited by acute psychological and inflammatory stresses in rabbits', American Journal of Physiology: Regulatory Integrative and Comparative Physiology, 289 596-604 (2005) [C1]
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2004 |
Ootsuka Y, Nalivaiko E, Blessing WW, 'Spinal 5-HT2A receptors regulate cutaneous sympathetic vasomotor outflow in rabbits and rats; relevance for cutaneous vasoconstriction elicited by MDMA (3,4-methylenedioxymethamphetamine, "Ecstasy") and its reversal by clozapine', BRAIN RESEARCH, 1014 34-44 (2004)
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2004 |
Nalivaiko E, Blessing W, 'CRF1 receptor antagonist CP-154,526 reduces cardiovascular responses during acute psychological stress in rabbits', Brain Research, 1017 234-237 (2004) [C1]
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2004 |
Oostuka Y, Nalivaiko E, Blessing WW, 'Spinal 5-HT2A receptors regulate cutaneous sympathetic vasomotor outflow in rabbits and rats; relevance for cutaneous vasoconstriction elicited by MDMA (3,4-methylenedioxymethamphetamine, "Ecstasy") and its reversal by clozapine', Brain Research, 1014 34-44 (2004) [C1]
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2004 |
Nalivaiko E, De Pasquale CG, Blessing WW, 'Ventricular arrhythmias triggered by alerting stimuli in conscious rabbits pre-treated with dofetilide', Basic Research in Cardiology, 99 142-151 (2004) [C1]
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2003 |
Nalivaiko E, De Pasquale CG, Blessing WW, 'Electrocardiographic changes associated with the nasopharyngeal reflex in conscious rabbits: Vago-sympathetic co-activation', Autonomic Neuroscience: Basic and Clinical, 105 101-104 (2003) [C1]
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2003 |
Nalivaiko E, Blessing WW, 'CRF1-receptor antagonist CP-154526 reduces alerting-related cutaneous vasoconstriction in conscious rabbits', Neuroscience, 117 129-138 (2003) [C1]
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2002 |
Nalivaiko E, Blessing WW, 'Potential role of medullary raphe-spinal neurons in cutaneous vasoconstriction: An in vivo electrophysiological study', JOURNAL OF NEUROPHYSIOLOGY, 87 901-911 (2002)
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2001 |
Nalivaiko E, Blessing WW, 'Raphe region mediates changes in cutaneous vascular tone elicited by stimulation of amygdala and hypothalamus in rabbits', BRAIN RESEARCH, 891 130-137 (2001)
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2001 |
Garcia JN, Pedersen NP, Nalivaiko E, Blessing WW, 'Tail artery blood flow measured by chronically implanted Doppler ultrasonic probes in unrestrained conscious rats', JOURNAL OF NEUROSCIENCE METHODS, 104 209-213 (2001)
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2001 |
Blessing WW, Nalivaiko E, 'Raphe magnus/pallidus neurons regulate tail but not mesenteric arterial blood flow in rats', NEUROSCIENCE, 105 923-929 (2001)
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2000 |
Blessing WW, Nalivaiko E, 'Regional blood flow and nociceptive stimuli in rabbits: patterning by medullary raphe, not ventrolateral medulla', JOURNAL OF PHYSIOLOGY-LONDON, 524 279-292 (2000)
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2000 |
Blessing WW, Nalivaiko E, 'Cutaneous vascular bed is not involved in arterial pressure changes elicited by increasing or decreasing the activity of inhibitory vasomotor neurons in caudal ventrolateral medulla in rabbits', NEUROSCIENCE LETTERS, 290 141-144 (2000)
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1999 |
Blessing WW, Yu YH, Nalivaiko E, 'Medullary projections of rabbit carotid sinus nerve', BRAIN RESEARCH, 816 405-410 (1999)
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1999 |
Nalivaiko E, Blessing WW, 'Synchronous changes in ear and tail blood flow following salient and noxious stimuli in rabbits', BRAIN RESEARCH, 847 343-346 (1999)
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1999 |
Blessing WW, Yu YH, Nalivalko E, 'Raphe pallidus and parapyramidal neurons regulate ear pinna vascular conductance in the rabbit', NEUROSCIENCE LETTERS, 270 33-36 (1999)
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1998 |
Nalivaiko E, Michaud JC, Soubrie P, Le Fur G, 'Electrophysiological evidence for putative subtypes of neurotensin receptors in guinea-pig mesencephalic dopaminergic neurons', NEUROSCIENCE, 86 799-811 (1998)
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1997 |
Nalivaiko E, Michaud JC, Soubrie P, LeFur G, Feltz P, 'Tachykinin neurokinin-1 and neurokinin-3 receptor-mediated responses in guinea-pig substantia nigra: An in vitro electrophysiological study', NEUROSCIENCE, 78 745-757 (1997)
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1991 |
BOCHET P, DUTRIAUX A, LAMBOLEZ B, NALIVAIKO E, ROSSIER J, DECARVALHO LP, 'A CHIMERIC GLUTAMATE RECEPTOR SUBUNIT - DISCRETE CHANGES MODIFY THE PROPERTIES OF THE CHANNEL', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 177 1183-1187 (1991)
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1988 |
NALIVAIKO ED, MIRONOV SL, 'THE CONCANAVALIN-A EFFECT ON THE INTRACELLULAR CONCENTRATION OF CALCIUM-IONS AND TRANSMEMBRANE POTENTIAL IN THE RABBIT LYMPOCYTES', FIZIOLOGICHESKII ZHURNAL, 34 84-87 (1988) |
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1988 |
Nalivaiko ED, Mironov SL, 'Effect of concanavalin A on the intracellular concentration of calcium ions and transmembrane potential of lymphocytes of the rabbit', Fiziologicheskii Zhurnal, 34 84-87 (1988) |
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1986 |
VESELOVSKII HS, NALIVAIKO ED, 'CHANGES IN CALCIUM ACTION-POTENTIALS IN NEURONS OF THE RAT SPINAL GANGLIA DURING REPLACEMENT OF DIVALENT-CATIONS IN THE EXTRACELLULAR MEDIUM', NEUROPHYSIOLOGY, 18 150-154 (1986)
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1986 |
Veselovskii NS, Nalivaiko ED, 'Isolation, identification and properties of the calcium component of the action potential in isolated neurons of the spinal ganglia of the rat', Neirofiziologiia = Neurophysiology, 18 126-129 (1986)
Electrophysiological properties of isolated dorsal root ganglion neurons from adult rats were studied by intracellular microelectrodes. All investigated cells were separated into ... [more]
Electrophysiological properties of isolated dorsal root ganglion neurons from adult rats were studied by intracellular microelectrodes. All investigated cells were separated into two groups according to the duration of their action potential and the shape of its falling phase. The calcium component of the action potential could be separated by placing the cells into sodium-free, calcium- and TEA-containing medium. The presence of this component was revealed in all studied neurons.
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1986 |
Nalivaiko ED, 'Modulation of calcium conductance of the somatic membrane of sensory neurons of the rat upon activation of the adenylate cyclase system', Neirofiziologiia = Neurophysiology, 18 557-560 (1986)
Intracellular second messenger system modifies the function of the voltage-dependent calcium conductance. Changes in the latter were investigated under the influence of cholera to... [more]
Intracellular second messenger system modifies the function of the voltage-dependent calcium conductance. Changes in the latter were investigated under the influence of cholera toxin (potent activator of adenylate cyclase). It was found that lower concentrations of toxin led to an increase of calcium conductance, while higher concentrations suppressed it. The bell-shaped dependence between calcium conductance and cholera toxin concentration indicates that cAMP-dependent protein kinase is connected with the intracellular cAMP concentration in the same way, i.e. a rise of the cAMP concentration from the basal level first activates protein kinase and then results in the inhibitory effect due to the cAMP excess.
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1986 |
Veselovskii NS, Nalivaiko ED, 'Changes in the calcium action potentials of the neurons of the spinal ganglia in the rat in response to divalent cation substitution in the extracellular medium', Neirofiziologiia = Neurophysiology, 18 202-207 (1986)
Rat dorsal root ganglion neurons were investigated by intracellular microelectrodes using current clamp technique. After elimination of sodium ions from the extracellular medium a... [more]
Rat dorsal root ganglion neurons were investigated by intracellular microelectrodes using current clamp technique. After elimination of sodium ions from the extracellular medium and addition of TEA pure "calcium" action potentials were recorded. Progressive and selective disturbance of such potentials was observed during continuous intracellular recording indicating a decrease in the calcium conductance while sodium and potassium conductances remained uneffected. Such a disturbance is supposed to be due to excessive influx of calcium, strontium or barium ions into the cell. The calcium component of the action potential was also dependent on the stimulation frequency, such dependence being different for strontium or barium solutions. Possible participation of current-dependent inactivation in the origin of this phenomenon is discussed.
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