Understanding Molecular Mechanisms that Regulate Spermatogonial Stem Cell Function
Closing Date: 10 February 2020
An exciting opportunity to uncover novel molecular mechanisms that regulate spermatogonial stem cell function using cutting-edge technologies such as single cell RNA sequencing, modern proteomics and lipidomics.
Spermatogonial stem cells (SSCs) are the indispensable self-renewing reservoir that drive ongoing sperm production to sustain male fertility. These cells also have the potential to act as a therapeutic tool to reverse chemotherapy-induced infertility, particularly in survivors of paediatric cancers. Unfortunately, there are gaps-in-knowledge surrounding how SSC function is regulated, limiting our ability to understand and treat male infertility. Our research team utilises cutting-edge technologies, such as single cell RNA sequencing, modern proteomics and lipidomics, to better understand molecular mechanisms that drive SSC maintenance and self-renewal. In this project, the successful applicant will incorporate these techniques along with functional experiments using transgenic mouse lines to ultimately characterise novel molecular networks that define SSC activity. The project is situated within the Priority Research Centre for Reproductive Biology at the University of Newcastle; a strategic initiative comprising >100 research personnel and students focused on different aspects of gamete biology and their relevance to human infertility, domestic animal reproduction, novel contraceptive development, and the conservation of Australian fauna. The strength of our research environment has been recognised through the Australian Government Excellence in Research Assessment initiative (ERA 2018), in which the UON was placed equal 7th for research that is 'well above world standard'. In our particular fields of Paediatrics & Reproductive Medicine and Biochemistry & Cell Biology, we were one of only 2 Universities to receive the highest ERA rating of 5. This project is laboratory-based and is expected to be undertaken onsite in Newcastle, full-time.
PhD Scholarship details
$28,092 per annum (2020 rate) indexed annually. For a PhD candidate, the living allowance scholarship is for 3.5 years and the tuition fee scholarship is for four years. This PhD package also includes a laptop and $1750 per annum dedicated to conference travel.
Supervisor: Tessa Lord
Available to: Domestic students
In addition to the minimum eligibility criteria, we encourage students with a background in Biomedical Sciences or Biology to apply. The successful candidate must commence before 31st March 2020.
Supervisors: Dr Tessa Lord, Dr Elizabeth Bromfield and Professor Brett Nixon.
Interested applicants should send an email expressing their interest along with a copy of their academic transcript, CV, and a brief statement of their research experience. Please send the email expressing interest to Tessa.firstname.lastname@example.org by 5pm on 10th February 2020.
Please send the email expressing interest to email@example.com by 5pm on 10 February 2020.
Applications Close 10 February 2020
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