CLINICAL TOXICOLOGY
Research Group

Pharmacokinetics and Pharmacodynamics of Drug Overdose STUDY

After taking or swallowing some medications, drug levels can be taken to find out how toxic the amount of medication taken is. This is commonly done with well-known medications such as paracetamol and aspirin. Drug levels are used to help decide on different treatments. For many newer medications we have limited information on drug levels in blood after an overdose.  Therefore, this study will measure the drug levels in blood after an overdose of the drug. This will help us find out whether drug levels are important for deciding on the severity of poisoning after a drug overdose. The study will also find out how long the human body takes to get rid of a drug (how long the effects of the drug will take to wear off). This information can then be used to decide whether drug levels should be taken routinely, or whether they are not required, for each type of drug.

Pregabalin Gabapentin Toxicity Project (PGTP)

Pregabalin and gabapentin are commonly prescribed for epilepsy and, chronic and neuropathic pain in Australia.  In view of very limited recent research pregabalin particularly may display a potential for abuse among individuals with a history of chronic opiate intake. The Pregabalin Gabapentin Toxicity Project (PGTP) aims to therefore investigate the pharmacokinetics and dynamics of these two drugs in overdose. Patients with pregabalin or gabapentin poisoning/overdose are recruited to the study and clinical and laboratory information is collected on datasheets. Additional blood samples are also collected from the patient for further profiling.