The Centre for Chemical Biology seeks to unravel the causes of disease by identifying crucial biological targets and pioneering the rapid development of novel drugs for the fight against disease.

Priority Research Centre for


2013 | 2012 | 2011 | 2010 | 2009 | 2008


Scrambled and Fried: Cigarette Smoke Exposure Causes Antral Follicle Destruction and Oocyte Dysfunction Through Oxidative Stress.  Sobinoff AP, Beckett EL, Jarnicki A, Sutherland JM, McCluskey A, Hansbro PM, McLaughlin EA.  Toxicol Appl Pharmacol. 2013 May 18. doi:pii: S0041-008X(13) 00206-8. 10.1016/j.taap.2013.05.009. [Epub ahead of print]

The Chemokine CXCL12 and it's Receptor CXCR4 are implicated in Human Seminoma Metastasis.  McIver SC, Loveland KL, Roman SD, Nixon B, Kitazawa R, McLaughlin EA.  Andrology. 2013 May;1(3):517-29. doi: 10.1111/j.2047-2927.2013.00081.x.  Epub 2013 Mar 15.

The Rise of Testicular Germ Cell Tumours: the Search for Causes, Risk Factors and Novel Therapeutic Targets.McIver SC, Roman SD, Nixon B, Loveland KL, McLaughlin EA.  F1000 Research 2013, 2:55. doi: 10.12688/f1000research.2-55.v1)
The Musashi Family of RNA Binding Proteins: Master Regulators of Multiple Stem Cell Populations. Sutherland JM, McLaughlin EA, Hime GR, Siddall NA.  Adv Exp Med Biol. 2013;786:233-45. doi: 10.1007/978-94-007-6621-1_13.
Immune Regulation of Ovarian Development: Programming by Neonatal Immune Challenge. . Sominsky L, Sobinoff AP, Jobling MS, Pye V, McLaughling EA, Hodgson DM.  Front Neuroscie. 2013 June 12;7:100.  doi: 10.3389/fnins.2013.00100.  Print 2013.
The BRCA1-Binding Protein BRAP2 Can Act as a Cytoplasmic Retention Factor for Nuclear and Nuclear Envelope-Localizing Testicular Proteins.  Davies RG, Wagstaff KM, McLaughlin EA, Loveland KA, Jans DA.  Biochim Biophys Acta. 2013 May 23, doi:pii: S0167-4889(13)00199-7. 10.1016/j.bbamcr.2013.05.015 [Epub ahead of print]
Single-Step Selection of Drug Resistant Acinetobacter baylyi ADP1 Mutants Reveals a Functional Redundancy in the Recruitment of Multidrug Efflux Systems. Brzoska AJ, Hassan KA, de Leon EJ, Paulsen IT, Lewis PL. PLoS One. 2013 Feb;8(2):1-11. [Epub ahead of print]
Investigation of the mechanisms by which the molecular chaperone HSPA2 regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition. Redgrove KA, Anderson AL, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B. Mol Hum Reprod. 2013 Jan 17. [Epub ahead of print]
Hidden gems in the niche: a new approach to the study of spermatogonial stem cells. Loveland KL, McLaughlin EA. Asian J Androl. 2013 Jan 14. doi: 10.1038/aja.2012.150. [Epub ahead of print] No abstract available.
Intracellular signalling during female gametogenesis. Sobinoff AP, Sutherland JM, McLaughlin EA. Mol Hum Reprod. 2013 Jan 6. [Epub ahead of print]


Reduced Chromosome Cohesion Measured by Interkinetochore Distance Is Associated with Aneuploidy Even in Oocytes from Young Mice. Merriman JA, Lane SI, Holt JE, Jennings PC, Garcia-Higuera I, Moreno S, McLaughlin EA, Jones KT. Biol Reprod. 2012 Dec 19. [Epub ahead of print]
Drosophila Rbp6 is an orthologue of vertebrate Msi-1 and Msi-2, but does not function redundantly with dMsi to regulate germline stem cell behaviour. Siddall NA, Kalcina M, Johanson TM, Monk AC, Casagranda F, Been RP, McLaughlin EA, Hime GR. PLoS One. 2012;7(11):e49810. doi: 10.1371/journal.pone.0049810. Epub 2012 Nov 27.
Staying alive: PI3K pathway promotes primordial follicle activation and survival in response to 3MC-induced ovotoxicity. Sobinoff AP, Nixon B, Roman SD, McLaughlin EA. Toxicol Sci. 2012 Jul;128(1):258-71. doi: 10.1093/toxsci/kfs137. Epub 2012 Apr 12.

Proteomic Insights into the Maturation and Capacitation of Mammalian Spermatozoa.Baker MA, Nixon B, Naumovski N, Aitken RJ. Syst Biol Reprod Med. 2012 Aug;58(4):211-7.

Investigation of the Expression and Functional Significance of the Novel Mouse Sperm Protein, A Disintegrin and Metalloprotease with Thrombospondin Type 1 Motifs Number 10 (ADAMTS10). Dun MD, Anderson AL, Bromfield EG, Asquith KL, Emmett B, McLaughlin EA, Aitken RJ, Nixon B. Int J Androl. 2012 Aug;35(4):572-89. doi: 10.1111/j.1365-2605.2011.01235.x. Epub 2012 Mar 28.
N-2-Propenyl-(5-dimethylamino)-1-naphthalene sulfonamide, A Novel Fluorescent Monomer for the Molecularly Imprinted Polymer Based Detection of 2,4-dinitrotoluene in the Gas Phase. Turner, N.W.; Bowyer, M.C.; McCluskey, A.; Holdsworth, C.I. Australian Journal of Chemistry 2012.
The Role of Molecular Chaperones in Spermatogenesis and the Post-Testicular Maturation of Mammalian Spermatozoa. Dun MD, Aitken RJ, Nixon B. Hum Reprod Update. 2012 Jul;18(4):420-35. Epub 2012 Apr 20.

Analysis of Synaptic Vesicle Endocytosis in Synaptosomes by High-Content Screening. Daniel JA, Malladi CS, Kettle E, McCluskey A, Robinson PJ. Nat Protoc. 2012 Jul 5;7(8):1439-55. doi: 10.1038/nprot.2012.070. PMID: 22767087

Chronic Exposure to Acrylamide Induces DNA Damage in Male Germ Cells of Mice. Nixon B, Stanger S, Nixon B, Roman S. Toxicol Sci. 2012 May 24. [Epub ahead of print]
A Unique Combination of Male Germ Cell miRNAs Coordinates Gonocyte Differentiation. McIver SC, Stanger SJ, Santarelli DM, Roman SD, Nixon B, McLaughlin EA. PLoS One. 2012;7(4):e35553. Epub 2012 Apr 20.
An ATR-FTIR Study on the Effect of Molecular Structural Variations on the CO(2) Absorption Characteristics of Heterocyclic Amines, Part II. Robinson K, McCluskey A, Attalla MI. ChemPhysChem. 2012 Apr 19. doi: 10.1002/cphc.201200066. [Epub ahead of print]. Robertson, M.J.; Hadzic, G.; Ambrus, J.; Hyde, E.; Mariana, A.; Robinson, P.J.; McCluskey, A.
The rhodadynsTM – novel inhibitors of dynamin GTPase. ACS Medicinal Chemistry Letters, 2012, 3, 352-356. Tarleton, M.; Bernhardt, P.V.; Authors, McCluskey, A. Crystal Structures of (3R,3aR,4S,7R,7aS)3(allyloxy)hexahydro-4,7-epoxyisobenzofuran-1(3H)one and (3S,3aR,4S,7R,7aS)-3((E)-but-2-en-1-yloxy)hexahydro-4,7-epoxyisobenzofuran-1(3H)-one: Confirmation of NMR predicted stereocentre geometry. Journal of Chemical Crystallography, 2012 DOI: 10.1007/s10870-012-0275-z.
Actin- and Dynamin-Dependent Maturation of Bulk Endocytosis Restores Neurotransmission following Synaptic Depletion. Nguyen TH, Maucort G, Sullivan RK, Schenning M, Lavidis NA, McCluskey A, Robinson PJ, Meunier FA. PLoS One. 2012;7(5):e36913. Epub 2012 May 22. [Epub ahead of print]
Neonatal immune challenge alters reproductive development in the female rat.Sominsky L, Meehan CL, Walker AK, Bobrovskaya L, McLaughlin EA, Hodgson DM. Horm Behav. 2012 Feb 14. [Epub ahead of print]
Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism. Buescher JM, Liebermeister W, Jules M, Uhr M, Muntel J, Botella E, Hessling B, Kleijn RJ, Le Chat L, Lecointe F, M??der U, Nicolas P, Piersma S, R??gheimer F, Becher D, Bessieres P, Bidnenko E, Denham EL, Dervyn E, Devine KM, Doherty G, Drulhe S, Felicori L, Fogg MJ, Goelzer A, Hansen A, Harwood CR, Hecker M, Hubner S, Hultschig C, Jarmer H, Klipp E, Leduc A, Lewis P, Molina F, Noirot P, Peres S, Pigeonneau N, Pohl S, Rasmussen S, Rinn B, Schaffer M, Schnidder J, Schwikowski B, Van Dijl JM, Veiga P, Walsh S, Wilkinson AJ, Stelling J, Aymerich S, Sauer U. Science. 2012 Mar 2;335(6072):1099-103.
Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis. Nicolas P, M??der U, Dervyn E, Rochat T, Leduc A, Pigeonneau N, Bidnenko E, Marchadier E, Hoebeke M, Aymerich S, Becher D, Bisicchia P, Botella E, Delumeau O, Doherty G, Denham EL, Fogg MJ, Fromion V, Goelzer A, Hansen A, H??rtig E, Harwood CR, Homuth G, Jarmer H, Jules M, Klipp E, Le Chat L, Lecointe F, Lewis P, Liebermeister W, March A, Mars RA, Nannapaneni P, Noone D, Pohl S, Rinn B, R??gheimer F, Sappa PK, Samson F, Schaffer M, Schwikowski B, Steil L, St??lke J, Wiegert T, Devine KM, Wilkinson AJ, van Dijl JM, Hecker M, V??lker U, Bessi??res P, Noirot P. Science. 2012 Mar 2;335(6072):1103-6.
Jumping the gun: Smoking constituent BaP causes premature primordial follicle activation and impairs oocyte fusibility through oxidative stress. Sobinoff AP, Pye V, Nixon B, Roman SD, McLaughlin EA. Toxicol Appl Pharmacol. 2012 Feb 8. [Epub ahead of print]
Differential roles of HOW in male and female Drosophila germline differentiation.Monk AC, Siddall NA, Fraser B, McLaughlin EA, Hime GR. PLoS One. 2011;6(12):e28508. Epub 2011 Dec 6.
Selective enrichment and identification of cross-linked peptides to study 3-D structures of protein complexes by mass spectrometry. Buncherd H, Nessen MA, Nouse N, Stelder SK, Roseboom W, Dekker HL, Arents JC, Smeenk LE, Wanner MJ, van Maarseveen JH, Yang X, Lewis PJ, de Koning LJ, de Koster CG, de Jong L. J Proteomics. 2012 Feb 4.
Whole Genome Methylation Scanning Based on phi29 Polymerase Amplification. Brooks R, Rose RJ, Sheahan MB, Kurdyukov S. Biochemistry (Mosc). 2011 Sep;76(9):999-1002. doi: 10.1134/S0006297911090021.
From embryo sac to oil and protein bodies: embryo development in the model legume Medicago truncatula. Wang XD, Song Y, Sheahan MB, Garg ML, Rose RJ. New Phytol. 2012 Jan;193(2):327-38. doi: 10.1111/j.1469-8137.2011.03925.x. Epub 2011 Oct 11.
PP2A phosphatase suppresses function of the mesenchymal invasion regulator NEDD9. Bradbury P, Mahmassani M, Zhong J, Turner K, Paul A, Verrills NM, O'Neill GM. Biochim Biophys Acta. 2012 Feb;1823(2):290-7. Epub 2011

Book Chapters

All Your Eggs in One Basket: Mechanisms of Xenobiotic Induced Female Reproductive Senescence, Senescence, Tetsuji Nagata (Ed.) Alexander P. Sobinoff, Ilana R. Bernstein and Eileen A. McLaughlin. ISBN: 978-953-51-0144-4, InTech,(2012).
The organisation of transcription and translation. In Bacillus: Cellular and Molecular Biology (2nd Ed). Lewis P, and Yang X, (2012) (P. Graumann ed), Caister Academic Press, ISBN: 978-1-904455-97-4. Chapter 5. pp 123-150.


Effect of Aging on Superovulation Efficiency, Aneuploidy Rates, and Sister Chromatid Cohesion in Mice Aged Up to 15 Months. Merriman JA, Jennings PC, McLaughlin EA, Jones KT. Biol Reprod. 2011 Nov 2. [Epub ahead of print]
A simple HPLC method for plasma level monitoring of mitotane and its two main metabolites in adrenocortical cancer patients.Garg MB, Sakoff JA, Ackland SP. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Aug 1;879(23):2201-5. Epub 2011 Jun 13.
miRNA and mammalian male germ cells. McIver SC, Roman SD, Nixon B, McLaughlin EA. Hum Reprod Update. 2011 Oct 11. [Epub ahead of print]
Norcantharimide analogues possessing terminal phosphate esters and their anti-cancer activity. Robertson MJ, Gordon CP, Gilbert J, McCluskey A, Sakoff JA. Bioorg Med Chem. 2011 Sep 15;19(18):5734-41. Epub 2011 Feb 1.
Inhibition of Dynamin by Dynole 34-2 Induces Cell Death following Cytokinesis Failure in Cancer Cells.Chircop M, Perera S, Mariana A, Lau H, Ma MP, Gilbert J, Jones NC, Gordon CP, Young KA, Morokoff A, Sakoff J, O'Brien TJ, McCluskey A, Robinson PJ. Mol Cancer Ther. 2011 Sep;10(9):1553-62. Epub 2011 Jul 12.
Norcantharidin analogues with nematocidal activity in Haemonchus contortus.Campbell BE, Tarleton M, Gordon CP, Sakoff JA, Gilbert J, McCluskey A, Gasser RB. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3277-81. Epub 2011 Apr 13.
Anti-malarial, anti-algal, anti-tubercular, anti-bacterial, anti-photosynthetic, and anti-fouling activity of diterpene and diterpene isonitriles from the tropical marine sponge Cymbastela hooperi.Wright AD, McCluskey A, Robertson MJ, MacGregor KA, Gordon CP, Guenther J. Org Biomol Chem. 2011 Jan 21;9(2):400-7. Epub 2010 Nov 2.
The antiplasmodial activity of norcantharidin analogs. Bajsa J, McCluskey A, Gordon CP, Stewart SG, Hill TA, Sahu R, Duke SO, Tekwani BL. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6688-95. Epub 2010 Sep 7.
The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction. Dun MD, Smith ND, Baker MA, Lin M, Aitken RJ, Nixon B. J Biol Chem. 2011 Aug 31. [Epub ahead of print]
Proteomic and functional analysis of human sperm detergent resistant membranes. Nixon B, Mitchell LA, Anderson AL, McLaughlin EA, O'Bryan MK, Aitken RJ. J Cell Physiol. 2011 Oct;226(10):2651-65. doi: 10.1002/jcp.22615.
Understanding the villain: DMBA induced pre-antral ovotoxicity involves selective follicular destruction and primordial follicle activation through PI3K/Akt and mTOR signalling. Sobinoff AP, Mahony M, Nixon B, Roman SD, McLaughlin EA. Toxicol Sci. 2011 Jul 23. [Epub ahead of print]
Translational control in germ cell development: A role for the RNA-binding proteins Musashi-1 and Musashi-2. Gunter KM, McLaughlin EA. IUBMB Life. 2011 Jul 15. doi: 10.1002/iub.499. [Epub ahead of print]
Involvement of multimeric protein complexes in mediating the capacitation-dependent binding of human spermatozoa to homologous zonae pellucidae. Redgrove KA, Anderson AL, Dun MD, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B. Dev Biol. 2011 Aug 15;356(2):460-74. Epub 2011 Jun 13.
Suppressor of cytokine signalling 4 (SOCS4): moderator of ovarian primordial follicle activation. Sutherland JM, Keightley RA, Nixon B, Roman SD, Robker RL, Russell DL, McLaughlin EA. J Cell Physiol. 2011 May 20. doi: 10.1002/jcp.22837. [Epub ahead of print]
Cellular mechanisms regulating sperm-zona pellucida interaction. Reid AT, Redgrove K, Aitken RJ, Nixon B. Asian J Androl. 2011 Jan;13(1):88-96.
Dynamin inhibition blocks botulinum neurotoxin type-A endocytosis in neurons and delays botulism. Harper CB, Martin S, Nguyen TH, Daniels SJ, Lavidis NA, Popoff MR, Hadzic G, Mariana A, Chau N, McCluskey A, Robinson PJ, Meunier FA. J Biol Chem. 2011 Aug 5. [Epub ahead of print]
Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition. von Kleist L, Stahlschmidt W, Bulut H, Gromova K, Puchkov D, Robertson MJ, Macgregor KA, Tomlin N, Pechstein A, Chau N, Chircop M, Sakoff J, von Kries JP, Saenger W, Kr??usslich HG, Shupliakov O, Robinson PJ, McCluskey A, Haucke V. Cell. 2011 Aug 5;146(3):471-84.
The electrophoretic separation of spermatozoa: an analysis of genotype, surface carbohydrate composition and potential for capacitation. Ainsworth CJ, Nixon B, Aitken RJ. Int J Androl. 2011 May 12. doi: 10.1111/j.1365-2605.2011.01164.x. [Epub ahead of print]
Monotremes Provide a Key to Understanding the Evolutionary Significance of Epididymal Sperm Maturation. Nixon B, Ecroyd HW, Dacheux JL, Jones RC. J Androl. 2011 Mar 25. [Epub ahead of print]
Norcantharidin analogues with nematocidal activity in Haemonchus contortus. Campbell BE, Tarleton M, Gordon CP, Sakoff JA, Gilbert J, McCluskey A, Gasser RB. Bioorg Med Chem Lett. 2011 Apr 13. [Epub ahead of print]
An FTIR Spectroscopic Study on the Effect of Molecular Structural Variations on the CO(2) Absorption Characteristics of Heterocyclic Amines. Robinson K, McCluskey A, Attalla MI. Chemphyschem. 2011 Apr 18;12(6):1088-99. Epub 2011 Apr 5.
Identification of Novel Diagnostic Biomarkers for Asthma and Chronic Obstructive Pulmonary Disease. Verrills NM, Irwin JA, He XY, Wood LG, Powell H, Simpson JL, McDonald VM, Sim A, Gibson PG. Am J Respir Crit Care Med. 2011 Mar 18. [Epub ahead of print]
Characterisation of the legume SERK-NIK gene superfamily including splice variants: implications for development and defence. Nolan KE, Kurdyukov S, Rose RJ. BMC Plant Biol. 2011 Mar 9;11:44.
Essential Role of Protein Phosphatase 2A in Metaphase II Arrest and Activation of Mouse Eggs Shown by Okadaic Acid, Dominant Negative Protein Phosphatase 2A, and FTY720. Chang HY, Jennings PC, Stewart J, Verrills NM, Jones KT. J Biol Chem. 2011 Apr 22;286(16):14705-12. Epub 2011 Mar 7.
Investigation of the one-pot synthesis of quinolin-2-(1H)-ones and the discovery of a variation of the three-component Ugi reaction. Gordon CP, Young KA, Hizartzidis L, Deane FM, McCluskey A. Org Biomol Chem. 2011 Mar 7;9(5):1419-28..
Activation of XerCD-dif recombination by the FtsK DNA translocase. Grainge I, Lesterlin C, Sherratt DJ. Nucleic Acids Res. 2011 Mar 2. [Epub ahead of print]
Ontogeny of embryogenic callus in Medicago truncatula: the fate of the pluripotent and totipotent stem cells. Wang XD, Nolan KE, Irwanto RR, Sheahan MB, Rose RJ. Ann Bot. 2011 Apr;107(4):599-609. Epub 2011 Jan 10.
The interaction between bacterial transcription factors and RNA polymerase during the transition from initiation to elongation. Yang X, Lewis PJ. Transcription. 2010 Sep;1(2):66-69. Epub 2010 Jun 25.
Controlling the cell cycle: The role of calcium/calmodulin-stimulated protein kinases I and II.Skelding KA, Rostas JA, Verrills NM. Cell Cycle. 2011 Feb 15;10(4):631-9. Epub 2011 Feb 15.
Neonatal lipopolysaccharide exposure impairs sexual development and reproductive success in the Wistar rat. Walker AK, Hiles SA, Sominsky L, McLaughlin EA, Hodgson DM. Brain Behav Immun. 2011 Jan 18. [Epub ahead of print]
Ontogeny of embryogenic callus in Medicago truncatula: the fate of the pluripotent and totipotent stem cells. Wang XD, Nolan KE, Irwanto RR, Sheahan MB, Rose RJ. Ann Bot. 2011 Jan 10. [Epub ahead of print]
C4 plants as biofuel feedstocks: optimising biomass production and feedstock quality from a lignocellulosic perspective. Byrt CS, Grof CP, Furbank RT. J Integr Plant Biol. 2011 Feb;53(2):120-35.


Proteomic and functional analysis of human sperm detergent resistant membranes.Nixon B, Mitchell LA, Anderson A, McLaughlin EA, O'Bryan MK, Aitken RJ.J Cell Physiol. 2010 Dec 28. [Epub ahead of print]
A soluble acid invertase is directed to the vacuole by a signal anchor mechanism.Rae AL, Casu RE, Perroux JM, Jackson MA, Grof CP.J Plant Physiol. 2010 Dec 12. [Epub ahead of print]
FtsK--a bacterial cell division checkpoint? Grainge I. Mol Microbiol. 2010 Dec;78(5):1055-7.
A simple plasmid-based system that allows rapid generation of tightly controlled gene expression in Staphylococcus aureus.Liew A, Theis T, Jensen S, Garcia-Lara J, Foster SJ, Firth N, Lewis PJ, Harry EJ. Microbiology.2010 Nov 25. [Epub ahead of print]
Anti-malarial, anti-algal, anti-tubercular, anti-bacterial, anti-photosynthetic, and anti-fouling activity of diterpene and diterpene isonitriles from the tropical marine sponge Cymbastela hooperi. Wright AD, McCluskey A, Robertson MJ, MacGregor KA, Gordon CP, Guenther J.Org Biomol Chem. 2011 Jan 21;9(2):400-7. Epub 2010 Nov 2.
Cellular mechanisms regulating sperm-zona pellucida interaction. Reid AT, Redgrove K, Aitken RJ, Nixon B. Asian J Androl. 2011 Jan;13(1):88-96. Epub 2010 Nov 1.
Spermatids do it differently! Paip2a-the essential regulator of spermiogenesis? McLaughlin EA, Hime GR.Asian J Androl. 2011 Jan;13(1):122-4. Epub 2010 Nov 1. No abstract available.
FtsK DNA translocase: the fast motor that knows where it's going.Crozat E, Grainge I.Chembiochem. 2010 Nov 2;11(16):2232-43. Review.
The antiplasmodial activity of norcantharidin analogs.Bajsa J, McCluskey A, Gordon CP, Stewart SG, Hill TA, Sahu R, Duke SO, Tekwani BL. Bioorg Med Chem Lett.2010 Nov 15;20(22):6688-95. Epub 2010 Sep 7.
Sperm-zona pellucida interaction: molecular mechanisms and the potential for contraceptive intervention. Dun MD, Mitchell LA, Aitken RJ, Nixon B.Handb Exp Pharmacol. 2010;(198):139-78.
New insights into sperm physiology and pathology.  Aitken RJ, Baker MA, De Iuliis GN, Nixon B.Handb Exp Pharmacol. 2010;(198):99-115. Review
Contraception targets in Mammalian ovarian development. McLaughlin EA, Sobinoff AP. Handb Exp Pharmacol. 2010;(198):45-66. Review.
Adding insult to injury: effects of xenobiotic-induced preantral ovotoxicity on ovarian development and oocyte fusibility. Sobinoff AP, Pye V, Nixon B, Roman SD, McLaughlin EA. Toxicol Sci. 2010 Dec;118(2):653-66. Epub 2010 Sep 9.
Serine/threonine phosphatases in socioeconomically important parasitic nematodes--prospects as novel drug targets? Campbell BE, Hofmann A, McCluskey A, Gasser RB. Biotechnol Adv. 2011 Jan-Feb;29(1):28-39. Epub 2010 Aug 21.
Small subunits of RNA polymerase: localization, levels and implications for core enzyme composition.  Doherty GP, Fogg MJ, Wilkinson AJ, Lewis PJ. Microbiology. 2010 Dec;156(Pt 12):3532-43. Epub 2010 Aug 19.
Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells. Howes MT, Kirkham M, Riches J, Cortese K, Walser PJ, Simpson F, Hill MM, Jones A, Lundmark R, Lindsay MR, Hernandez-Deviez DJ, Hadzic G, McCluskey A, Bashir R, Liu L, Pilch P, McMahon H, Robinson PJ, Hancock JF, Mayor S, Parton RG. J Cell Biol. 2010 Aug 23;190(4):675-91. Epub 2010 Aug 16.
Protein phosphatase 2A carboxymethylation and regulatory B subunits differentially regulate mast cell degranulation. Kranias G, Watt LF, Carpenter H, Holst J, Ludowyke R, Strack S, Sim AT, Verrills NM.Cell Signal. 2010 Dec;22(12):1882-90.
The pthaladyns: GTP competitive inhibitors of dynamin I and II GTPase derived from virtual screening.Odell LR, Howan D, Gordon CP, Robertson MJ, Chau N, Mariana A, Whiting AE, Abagyan R, Daniel JA, Gorgani NN, Robinson PJ, McCluskey A.J Med Chem. 2010 Jul 22;53(14):5267-80.
The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells. Joshi S, Perera S, Gilbert J, Smith CM, Mariana A, Gordon CP, Sakoff JA, McCluskey A, Robinson PJ, Braithwaite AW, Chircop M.Mol Cancer Ther. 2010 Jul;9(7):1995-2006. Epub 2010 Jun 22.
Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers. Roberts KG, Smith AM, McDougall F, Carpenter H, Horan M, Neviani P, Powell JA, Thomas D, Guthridge MA, Perrotti D, Sim AT, Ashman LK, Verrills NM. Cancer Res. 2010 Jul 1;70(13):5438-47.
Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo. de Bock CE, Garg MB, Scott N, Sakoff JA, Scorgie FE, Ackland SP, Lincz LF. Pharmacogenomics J. 2010 Jun 8. [Epub ahead of print]
Essential biological processes of an emerging pathogen: DNA replication, transcription, and cell division in Acinetobacter spp.Robinson A, Brzoska AJ, Turner KM, Withers R, Harry EJ, Lewis PJ, Dixon NE.Microbiol Mol Biol Rev. 2010 Jun;74(2):273-97. Review.
Calcineurin activity is required for the completion of cytokinesis.Chircop M, Malladi CS, Lian AT, Page SL, Zavortink M, Gordon CP, McCluskey A, Robinson PJ.Cell Mol Life Sci. 2010 Nov;67(21):3725-37. Epub 2010 May 23.
The interaction between RNA polymerase and the elongation factor NusA. Yang X, Lewis PJ. RNA Biol. 2010 May-Jun;7(3):272-5. Epub 2010 May 7. Review.
Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis. Hill TA, Mariana A, Gordon CP, Odell LR, Robertson MJ, McGeachie AB, Chau N, Daniel JA, Gorgani NN, Robinson PJ, McCluskey A. J Med Chem. 2010 May 27;53(10):4094-102.
Is there a role for immunocontraception? McLaughlin EA, Aitken RJ. Mol Cell Endocrinol. 2011 Mar 15;335(1):78-88. Epub 2010 Apr 20.
Separating speed and ability to displace roadblocks during DNA translocation by FtsK. Crozat E, Meglio A, Allemand JF, Chivers CE, Howarth M, V??nien-Bryan C, Grainge I, Sherratt DJ. EMBO J. 2010 Apr 21;29(8):1423-33. Epub 2010 Apr 8.
HOW is required for stem cell maintenance in the Drosophila testis and for the onset of transit-amplifying divisions. Monk AC, Siddall NA, Volk T, Fraser B, Quinn LM, McLaughlin EA, Hime GR. Cell Stem Cell. 2010 Apr 2;6(4):348-60.
Sucrose transporters of higher plants. K??hn C, Grof CP. Curr Opin Plant Biol. 2010 Jun;13(3):288-98. Epub 2010 Mar 18.
The Escherichia coli DNA translocase FtsK. Sherratt DJ, Arciszewska LK, Crozat E, Graham JE, Grainge I.  Biochem Soc Trans. 2010 Apr;38(2):395-8. Review.
Elucidation of the signaling pathways that underpin capacitation-associated surface phosphotyrosine expression in mouse spermatozoa.  Nixon B, Bielanowicz A, Anderson AL, Walsh A, Hall T, Mccloghry A, Aitken RJ.  J Cell Physiol. 2010 Jul;224(1):71-83.
Glioma pathogenesis-related 1-like 1 is testis enriched, dynamically modified, and redistributed during male germ cell maturation and has a potential role in sperm-oocyte binding. Gibbs GM, Lo JC, Nixon B, Jamsai D, O'Connor AE, Rijal S, Sanchez-Partida LG, Hearn MT, Bianco DM, O'Bryan MK. Endocrinology. 2010 May;151(5):2331-42. Epub 2010 Mar 10.
Synthesis and biological activity of Delta-5,6-norcantharimides: importance of the 5,6-bridge. Thaqi A, Scott JL, Gilbert J, Sakoff JA, McCluskey A. Eur J Med Chem. 2010 May;45(5):1717-23. Epub 2010 Jan 14.
pBaSysBioII: an integrative plasmid generating gfp transcriptional fusions for high-throughput analysis of gene expression in Bacillus subtilis. Botella E, Fogg M, Jules M, Piersma S, Doherty G, Hansen A, Denham EL, Le Chat L, Veiga P, Bailey K, Lewis PJ, van Dijl JM, Aymerich S, Wilkinson AJ, Devine KM. Microbiology. 2010 Jun;156(Pt 6):1600-8. Epub 2010 Feb 11. Cell Signal. 2010 May;22(5):759-69.


New proteins identified in epididymal fluid from the platypus (Ornithorhynchus anatinus). Dacheux JL, Dacheux F, Labas V, Ecroyd H, Nixon B, Jones RC. Reprod Fertil Dev.
Testicular descent, sperm maturation and capacitation. Lessons from our most distant relatives, the monotremes. Ecroyd H, Nixon B, Dacheux JL, Jones RC. Reprod Fertil Dev. 2009;21(8):992-1001. Review.
The biological significance of detergent-resistant membranes in spermatozoa. Nixon B, Aitken RJ. J Reprod Immunol. 2009 Dec;83(1-2):8-13. Epub 2009 Oct 25. Review.
Antioxidant systems and oxidative stress in the testes. Aitken RJ, Roman SD. Oxid Med Cell Longev. 2008 Oct-Dec;1(1):15-24. Review. No abstract available.
The interaction of Bacillus subtilis sigmaA with RNA polymerase. Johnston EB, Lewis PJ, Griffith R. Protein Sci. 2009 Nov;18(11):2287-97.
The structure of bacterial RNA polymerase in complex with the essential transcription elongation factor NusA. Yang X, Molimau S, Doherty GP, Johnston EB, Marles-Wright J, Rothnagel R, Hankamer B, Lewis RJ, Lewis PJ. EMBO Rep. 2009 Sep;10(9):997-1002.
The association of homeobox gene expression with stem cell formation and morphogenesis in cultured Medicago truncatula. Chen SK, Kurdyukov S, Kereszt A, Wang XD, Gresshoff PM, Rose RJ. Planta. 2009 Sep;230(4):827-40.
The in vivo expression of dipeptidyl peptidases 8 and 9. Yu DM, Ajami K, Gall MG, Park J, Lee CS, Evans KA, McLaughlin EA, Pitman MR, Abbott CA, McCaughan GW, Gorrell MD. J Histochem Cytochem. 2009 Nov;57(11):1025-40. Epub 2009 Jul 6.
DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress. De Iuliis GN, Thomson LK, Mitchell LA, Finnie JM, Koppers AJ, Hedges A, Nixon B, Aitken RJ. Biol Reprod. 2009 Sep;81(3):517-24. Epub 2009 Jun 3.
Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. Hill TA, Gordon CP, McGeachie AB, Venn-Brown B, Odell LR, Chau N, Quan A, Mariana A, Sakoff JA, Chircop M, Robinson PJ, McCluskey A. J Med Chem. 2009 Jun 25;52(12):3762-73.
Azido and diazarinyl analogues of bis-tyrphostin as asymmetrical inhibitors of dynamin GTPase. Odell LR, Chau N, Mariana A, Graham ME, Robinson PJ, McCluskey A.
Expression of the SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE1 (SERK1) gene is associated with developmental change in the life cycle of the model legume Medicago truncatula. Nolan KE, Kurdyukov S, Rose RJ. J Exp Bot. 2009;60(6):1759-71. Epub 2009 Mar 19.
Steroids from an Australian sponge Psammoclema sp. Holland IP, McCluskey A, Sakoff JA, Gilbert J, Chau N, Robinson PJ, Motti CA, Wright AD, van Altena IA. J Nat Prod. 2009 Jan;72(1):102-6.


Biochemical characterization of the minichromosome maintenance (MCM) protein of the crenarchaeote Aeropyrum pernix and its interactions with the origin recognition complex (ORC) proteins. Atanassova N, Grainge I. Biochemistry. 2008 Dec 16;47(50):13362-70.
Norcantharidin analogues: synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition. Hill TA, Stewart SG, Gordon CP, Ackland SP, Gilbert J, Sauer B, Sakoff JA, McCluskey A. ChemMedChem. 2008 Dec;3(12):1878-92.
Molecular architecture of the "stressosome," a signal integration and transduction hub. Marles-Wright J, Grant T, Delumeau O, van Duinen G, Firbank SJ, Lewis PJ, Murray JW, Newman JA, Quin MB, Race PR, Rohou A, Tichelaar W, van Heel M, Lewis RJ. Science. 2008 Oct 3;322(5898):92-6.
Awakening the oocyte: controlling primordial follicle development. McLaughlin EA, McIver SC. Reproduction. 2009 Jan;137(1):1-11. Epub 2008 Sep 30. Review.
Quantification of hTERT splice variants in melanoma by SYBR green real-time polymerase chain reaction indicates a negative regulatory role for the beta deletion variant. Lincz LF, Mudge LM, Scorgie FE, Sakoff JA, Hamilton CS, Seldon M.Neoplasia. 2008 Oct;10(10):1131-7.
Sporulation: SpoIIIE is the key to cell differentiation. Grainge I. Curr Biol. 2008 Sep 23;18(18):R871-2.
Composition and significance of detergent resistant membranes in mouse spermatozoa. Nixon B, Bielanowicz A, McLaughlin EA, Tanphaichitr N, Ensslin MA, Aitken RJ. J Cell Physiol. 2009 Jan;218(1):122-34.
Molecular mechanism of sequence-directed DNA loading and translocation by FtsK. L??we J, Ellonen A, Allen MD, Atkinson C, Sherratt DJ, Grainge I. Mol Cell. 2008 Aug 22;31(4):498-509.
Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa. Koppers AJ, De Iuliis GN, Finnie JM, McLaughlin EA, Aitken RJ. J Clin Endocrinol Metab. 2008 Aug;93(8):3199-207. Epub 2008 May 20.
The transcription factor MtSERF1 of the ERF subfamily identified by transcriptional profiling is required for somatic embryogenesis induced by auxin plus cytokinin in Medicago truncatula. Mantiri FR, Kurdyukov S, Lohar DP, Sharopova N, Saeed NA, Wang XD, Vandenbosch KA, Rose RJ. Plant Physiol. 2008 Apr;146(4):1622-36. Epub 2008 Jan 30.
Arsenic and heavy metal accumulation by Pteris vittata L. and P. umbrosa R. Br. Koller CE, Patrick JW, Rose RJ, Offler CE, MacFarlane GR. Bull Environ Contam Toxicol. 2008 Feb;80(2):128-33. Epub 2008 Jan 9.
A role for altered microtubule polymer levels in vincristine resistance of childhood acute lymphoblastic leukemia xenografts. Ong V, Liem NL, Schmid MA, Verrills NM, Papa RA, Marshall GM, Mackenzie KL, Kavallaris M, Lock RB. J Pharmacol Exp Ther. 2008 Feb;324(2):434-42.