Emeritus Professor Saxon White
Emeritus Professor
School of Biomedical Sciences and Pharmacy (Human Physiology)
Career Summary
Biography
My father left the Australian Navy in 1946 and joined the staff of The King’s School, Parramatta, and we moved home to Parramatta, where we lived close to my father’s cousins, the Benauds, and of course Richie and John. At this time I finished at Woollahra Primary Opportunity Class and commenced at Sydney Boys High School moving after 6 months to Parramatta High School and then to King’s in November 1946. At King’s I became school captain and played combined GPS firsts Cricket and Rugby for 2 years. In 1953 I enrolled on Commonwealth Scholarship in Medicine at the University of Sydney and on Bursary at St Andrew’s College, but my undergraduate career was interrupted twice each for one year to tour with the Australian Rugby (Wallaby) team first to South Africa (1953) and then the British Isles, France and North America (1957-58). So in 1953 I was touring South Africa with the Wallabies when Richie was touring England simultaneously with the Australian Cricket team. As a Sydney University undergraduate, cricket and rugby club member, I played 7 rugby tests and 22 other tour games in the Australian colours, and my cricket career as an opening batsman NSW State Colts selection lapsed. I retired from all representative sport at age 24 in 1958 to concentrate on medicine.
After graduation in medicine I became professorial surgical registrar at the University of NSW Prince Henry Hospital and commenced research as a National Heart Foundation Fellow for a higher doctorate in medicine supervised by Professor Paul Korner at the University of NSW in cardiovascular reflex control during hypoxia including haemorrhagic shock. I graduated MD and in 1968 I became Overseas Life Insurance Research Fellow of Australia and New Zealand with tenure in 1968 in the Department of Physiology, University of Goteborg, Sweden working with Professor Bjorn Folkow and Dr Bengt Oberg on microcirculation rheology and reflexes emanating from the heart.
In 1969, the Fellowship took me to the Scripps Clinic and Research Foundation, La Jolla, and the Department of Cardiology, University of California, San Diego, where I worked with the Professors Gene Braunwald and Dean Franklin. This was mainly on the coronary circulation in primate and canine species in behaviour and exercise. The third year of the Fellowship was in the Cardiology Department of the University of Sydney. In 1974 I moved to the new medical school at Flinders University of South Australia, but within 18 months took the Foundation Chair of Human Physiology at the newer medical school at the University of Newcastle. We were 2 years ahead of the first undergraduate student intake and we developed an innovative curriculum, built buildings, and finally set up laboratories and took in postgraduate research students. My basic science research was in nervous control of the coronary and bronchial circulations using new ultrasonic techiniques. I also developed exercise stress testing in clinical cardiology at the Royal Newcastle Hospital and later at the new John Hunter Hospital at New Lambton. But a major innovation was our link with the Hunter Valley community in education and human research via my separate Human Performance Laboratory. We especially educated the community in the value of exercise for the maintenance of health, e.g. the HUFPUF Club of Merewether, and in endocrine research using ballet schools as a source of the female athlete. I also moved to create the Hunter Academy of Sport (1988- ) with its provision for sporting service, education and research.
In 2014 we service coached 26 separate sports for selected teenage talent squads. The Academy also provided for educational International Conferences, e.g. in 1989, 'Drugs in Sport, the Socio-Ethical and Medical Issues, [fully published, 1991, see elsewhere]. Its research commitment was through the Human Performance Laboratory at the University of Newcastle. It turns out these initiatives through the medical school and its community are continuing successfully, for which I will be eternally grateful to my wife Julie, my children Matthew, Lisa and Jessica, for their patience and support as we all grew and flourished in the Hunter Valley community.
Research ExpertiseMy philosophical goal is to help maintain Global Health, that is to say, the research and practice of sustaining health of human and animal populations as they interact with ecosystems on the planet. My physiological goal is to identify the integrated mechanisms neural and non-neural responsible for survival in the freely operating, natural state. A special goal is therefore to wherever possible experiment with conscious man and other awake mammalian species. This approach is justified by our knowledge that acute experimental research models using preparatory anaesthetic agents, surgery plus positive pressure ventilation disrupt in a variety of ways, the natural control systems we seek to identify. My research therefore involves developing appropriate (new) techniques and a large measure of experimental surgery for pre-implantation in, or application to, the recovered awake experimental model (e.g. the application of thermodilution, electromagnetic, ultrasonic and impedance methods for measuring cardiac function, blood flow and airways dimensions). This enables examination of postulates concerning dynamic physiological control in awake man and animal (in my case rat, rabbit, cat, dog, sheep, pig-tailed monkey, and baboon). A special but not only target is the sensory and central nervous control of the coronary and bronchial circulations by efferent autonomic effectors. One great advantage with this approach in awake species is the enabling of behavioural studies both at rest and when the species is mobile. We have correlated and analysed behaviour in terms of integrated, moment-to-moment autonomic, hormonal, and local autacoid responses, in both immediate and longer term domains. We have targeted emotion and published on Darwin's hypothesis of emotion, facial expression and linked autonomic responses. The biggest ongoing challenge is to analyse during exercise how the brain normally controls the coronary and bronchial (airways) circulations, and the airways themselves. These studies are relevant to the greatest killers of mammalian species on the planet when the normal, natural control systems are modified by disease, e.g. the cardiopulmonary conditions of coronary artery disease, hypertension (systemic and pulmonary), and the multiplicity of asthma syndromes. I have trained higher degree students in these philosophies since 1970 (see Teaching Expertise below). An understanding of pathological processes are compromised without an understanding of the normal mechanisms underpinning survival. Special environmental influences requiring analysis are different forms of tissue hypoxia, i.e. ischaemia secondary to heart disease, and the arterial hypoxia (acute and chronic) of pulmonary disease, altitude, and the extremes of mammalian (including sporting) performance, e.g. postural change, diving, and the exercise-induced hypoxia and pulmonary haemorrhage in thoroughbred racehorses. The review of functional correlates between vertebrate species offers fascinating insights into the evolutionary maintenance of cardiopulmonary survival mechanisms, which has been suggested as defence against tissue hypoxia. This has applied to lung barriers preventing inhaled harmful molecules from penetrating across airways into the systemic circulation, and the reasons for reflex autonomic vasoconstriction in the coronary circulation of the heart when this appears physiologically inappropriate. I have published 101 fully peer-reviewed Journal papers, Reviews and Book Chapters, and 122 Abstracts since 1970 (as at 22/1/2013)
Teaching Expertise
I have worked in 4 new medical schools during the evolution of their clinical and basic science curricula, namely, UNSW (1962-67), UC San Diego (1969), Flinders University of South Australia (1974-76), and as a Foundation Professor at the University of Newcastle, NSW (1976- ). Therefore, I have an evolutionary view of the change in medical school approaches to medical education internationally, and of the evolution within each school. Early in my career, I was a junior teacher, and simply followed the policy laid down by committees. Later I became a committee member and took part in developing policy as well as teaching. At Newcastle, I was responsible for initiating (e.g. Chairman of the initial Phase 1 of the new medical curriculum, ) and establishing policy and participating in new courses using problem-based learning (PBL), e.g. in both medicine and biomedical science courses we linked Group PBL tutorials to Interactive whole year learning sessions). We viewed Problem Based Learning in undergraduate curricula as analogous to the learning process in research My focus was also on the undergraduate, graduate, and postgraduate domains for research education and process. As a physiologist I trained higher degree students by initially working closely with them in the laboratory and while writing, a process where the variable capacity of students to become potentially independent researchers is efficiently revealed. At the University of Sydney and at the University of Newcastle I have trained 1 higher Doctorate in Medicine by thesis (MD), 9 PhD (6 medical, 1 veterinary, 2 science grads), 4 B Med Sci, and 5 Sci Hons students. I am currently mentoring in 'retirement' PhD and Honours students by invitation in Professor AW Quail's laboratory in the Medical Sciences Building at the University of Newcastle. I was also a Foundation member (Treasurer) of the Hunter PostGraduate Medical Institute, and represented the Institute on the Australian PostGraduate Federation of Medicine where I recommended policy changes in medical postgraduate learning. I also sat on the Part 1 Board for Basic Surgical Training, Royal Australasian College of Surgeons, and was intimately involved in the change of the College from an Examining Institution alone, to an Educational and Examining Institution. I have not published this experience widely, but encouraged others to do so, mainly because my publishing time was devoted to physiological research writing.
Administrative Expertise
I was a full-time researcher until I went in 1974 to the new Medical School at Flinders University for my brief tenure of 18 months, where I became Foundation Chairman of the Library Committee. On taking up the Foundation Chair at Newcastle Medical School in May 1976, I repeated this tenure, and also became Foundation Chair of the Research Committee. I also became Chairman of Phase I in the new curriculum responsible for planning and implementing the problem-based course when the students arrived in 1978. During the next 22 years I served on many committees of the medical faculty and the University, and became the elected President of the Association of Professors of the University of Newcastle. Externally I served on the National Heart Foundation Scientific Advisory Committee for some 10 yr, and as mentioned elsewhere, on the Australian Postgraduate Federation of Medicine, and on the (Part 1) Board of Examiners, of the Royal Australasian College of Surgeons.
Collaborations
In 1968 my primary collaboration after my higher doctorate in medicine in Australia was with Björn Folkow and Bengt Öberg at the University of Göteborg, Sweden. Here as a medical research fellow I learned a variety of original techniques developed in the Department of Physiology for studies in anaesthetised models of human physiology. We studied rheology and cardiac reflexes. In turn I demonstrated to the Scandinavian Physiological Society the preparation developed by Paul Korner in Australia for analysis of cardiac output control during hypoxia using thermodilution (a new technique not accepted fully at that time). The next year 1969 I became a cardiology fellow in the novel Seaweed Canyon large animal complex at UC San Diego, La Jolla, California, where a new approach to studies of reflex cardiopulmonary control was used. This was physiological realism. The techniques allowed continuous measurement of dynamic coronary blood flow and cardiac dimension changes under natural behavioural and reflex conditions using frequency shifted ultrasound as originally described by Christian Doppler. The techniques foreshadowed clinical echocardiography and like techniques. I worked with Gene Braunwald, and the inventor of the techniques, Dean Franklin. On return to Australia in 1970, I joined foundation science staff at the University of Sydney Cardiology Department, then known as the Hallstrom Institute. Collaboration was commenced between clinicians and basic scientists, and with the Veterinary School, and Pharmacology, through new higher degree students. In 1976 I accepted the Foundation Chair of Human Physiology at the new medical school, University of Newcastle. Collaborative research commenced with the Depts of Anaesthetics, and of Surgery, at the established Royal Newcastle Hospital. We evaluated Impedance Cardiography for measurement of cardiac function in man. We also commenced novel community collaborative studies, on the menstrual cycle of the female athlete in Hunter Ballet Schools, and on G-force adaptation of blood pressure control in RAAF fighter-pilots. I founded the Hunter Academy of Sport in 1989, as a community based, service, education and (university) research company, limited by guarantee. In 1991, I was invited by Respiratory Medicine, University of California, Davis, to commence long term collaboration on asthma, namely, on reflex control of airways and bronchial circulation during rest, behaviour (including sleep), and exercise. In 1999, I developed in conjunction with bioengineer Koullis Pitsillides at UC Davis the airways internal diameter assessment (AIDA) ultrasound technique for online tracking of airway dimensions and blood flow. This international University collaboration foreshadowed new University of Newcastle collaborative policy. It was timely, as the Faculty of Medicine was restructured into a Faculty of Health, and the Hunter Medical Research Institute came on line at the new John Hunter Hospital.
Qualifications
- Doctor of Medicine, University of New South Wales
- Bachelor of Medicine & Surgery, University of Sydney
Keywords
- Medical Education
- Neural Control of Cardiopulmonary Systems
Professional Experience
Academic appointment
Dates | Title | Organisation / Department |
---|---|---|
1/1/2002 - 1/12/2005 | Chairman | Council of St Andrew's College, University of Sydney Australia |
1/1/2002 - 1/12/2004 | Chairman | Hunter Heart-Lung Research Guild (Cardiovascular Research Programme) Australia |
1/1/2001 - | Honorary Professor | The University of Sydney Australia |
1/1/2000 - | Emeritus Professor of Human Physiology | University of Newcastle School of Biomedical Sciences and Pharmacy Australia |
1/1/2000 - | Emeritus Professor | University of Newcastle Australia |
1/5/1976 - 1/12/1999 | Professor of Human Physiology | University of Newcastle Discipline of Human Physiology, Faculty of Medicine Australia |
1/5/1976 - 1/12/1999 | Foundation Professor of Human Physiology | University of Newcastle Australia |
1/11/1974 - 1/5/1976 | Senior Lecturer in Human Physiology | Flinders University Discipline of Human Physiology Australia |
1/1/1971 - 1/11/1974 | Chapman Fellow in Cardiology | The University of Sydney Department of Cardiology Australia |
1/1/1968 - 1/12/1970 | Overseas Fellow of the Life Insurance Medical Research Fund of Australia and New Zealand | University of Gothenburg Life Officers of Australia and New Zealand Sweden |
1/1/1968 - 1/12/1970 | Overseas Fellow of the Life Insurance Medical Research Fund of Australia and New Zealand | University of California, San Diego Life Officers of Australia and New Zealand United States |
1/1/1968 - 1/12/1970 | Overseas Fellow of the Life Insurance Medical Research Fund of Australia and New Zealand | The University of Sydney Life Officers of Australia and New Zealand Australia |
1/1/1965 - 1/11/1967 | Research Fellow of National Heart Foundation of Australia | The University of New South Wales Department of Physiology Australia |
Membership
Dates | Title | Organisation / Department |
---|---|---|
Elected Fellow/ Member - Royal Australasian College of Surgeons | Royal Australasian College of Surgeons (RACS) Australia |
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14/7/2005 - | Member - Order of Australia | Council for the Order of Australia Australia |
11/8/2004 - | Elected Member & Fellow - Cardiac Society of Australia and NewZealand | Cardiac Society of Australia and NewZealand Australia |
14/7/1964 - | Elected Member - Australian Physiological Society | Australian Physiological Society Australia |
Professional appointment
Dates | Title | Organisation / Department |
---|---|---|
1/1/1994 - | Elected Member - American Physiological Society | American Physiological Society United States |
Teaching appointment
Dates | Title | Organisation / Department |
---|---|---|
1/1/1964 - 1/12/1964 | Senior Tutor in Surgery | The University of New South Wales Australia |
Awards
Award
Year | Award |
---|---|
2007 |
Service to Australian Rugby and to the University of Sydney Football Club Australian Rugby Union |
1993 |
Fellow of the Hunter Acdemy of Sport Company Limited by Guarantee |
Honours
Year | Award |
---|---|
2017 |
Life Member of University of Newcastle Retired Lecturers Association University of Newcastle Retired Lecturers Association |
2016 |
Life Membership Hunterpostgraduate Medical Institute Hunter Postgraduate Medical Institute |
2005 |
Member Order of Australia Unknown |
2005 |
Life Member of The Order of Australia Association Australian Govt Canberra |
1997 |
Life Member and Foundation President Lord's Taverners' Australia (Newcastle Br) Lord's Tavereners' Australia (Newcastle Branch) |
Recognition
Year | Award |
---|---|
2005 |
Fellow of St Andrew's College Unknown |
1988 |
Life Governor of the Australian Postgraduate Federation in Medicine Unknown |
Research Award
Year | Award |
---|---|
2011 |
Honorary (Life) Member Australian Physiological Society Australian Physiological Society |
1967 |
Overseas Fellowship of Life Insurance Fund of Australia and New Zealand Unknown |
Invitations
Distinguished Visitor
Year | Title / Rationale |
---|---|
2013 |
Invited Assessor on Selection Committees for full Professorial Appointments SEE BELOW 1980-2013 (all dated 1980 for reasons of candidate confidentiality) Organisation: Various Universities Description: External assessor of Candidate quality |
2013 |
Evolution of coronary circulation in man Organisation: University of California Davis Department of anesthesiology and pain medicine Description: Review of knowledge concerning the neural and non-neural control of coronary circulation in man |
1998 |
Get A Life. Achievement from nowhere; the stories of Isaac Newton, Heather Turland, and Greg Cooper (a young tyro with Sarcoma who became a father and an All Black) Organisation: The King's School, Parramatta Description: Speech Day Address. What now? A schoolboy fist-fight that found the greatest scientist the world has ever known; a mother who needed to get fit becomes an Olympic Champion; a young man with a sarcoma is whole body irradiation becomes an All Black and father. |
1991 |
On Parochialism: the Newcastle Medical School Experiment. Lambie-Dew Oration, The University of Sydney, Australia Organisation: The University of Sydney Medical School Society Description: The Lambie-Dew Oration, The University of Sydney, is an Annual event where a Distinguished Alumnus (usually) is invited to address the University in the Great Hall on a contemporary medical topic of interest |
1986 |
Once in a Lifetime: An Allegory. The story of the New Medical School at the University of Newcastle, Australia Organisation: The King's School, Parramatta Description: Invited Speech Day Address at the King's School, Parramatta |
External Examiner
Year | Title / Rationale |
---|---|
1991 |
Physiology, Otago University Organisation: Otago University Description: Invitation to examine and review examination processes and standards |
1990 |
Surgery, University of Western Australia Organisation: University of Western Australia Description: Invitation to examine and review examination processes and standards |
1990 |
Physiology, University of Tasmania Organisation: University of Tasmania Description: Invitation to examine and review examination processes and standards |
1989 |
Physiology, University of Tasmania Organisation: University of Tasmania Description: Invitation to examine and review examination processes and standards |
1985 |
Physiology, University of Singapore Organisation: University of Singapore Description: Invitation to examine and review examination processes and standards |
1985 |
Physiology, University of Malaya Organisation: University of Malaya Description: Invitation to examine and review examination processes and standards |
1985 |
Physiology, Otago University Organisation: Otago University Description: Invitation to examine and review examination processes and standards |
1984 |
Anaesthetics, first part College course and exams, Otago University Organisation: Otago University Description: Invited Physiology Course Co-ordinator for Anaesthetists, Part I Exam, Otago University |
1983 |
Physiology, University of Malaya Organisation: University of Malaya Description: Invitation to examine and review examination processes and standards |
1981 |
Physiology, University of Queensland Organisation: University of Queensland Description: Invitation to examine and review examination processes and standards |
1981 |
Physiology, University of Malaya Organisation: University of Malaya Description: Invitation to examine and review examination processes and standards |
1978 |
Physiology, University of Tasmania Organisation: University of Tasmania Description: Relatively new medical school extended an invitation to examine and review examination processes and standards |
Keynote Speaker
Year | Title / Rationale |
---|---|
2008 |
The Life and Times of Dean Franklin. The application of ultrasound to medical science. University of Missouri, USA Organisation: John M Dalton Cradiovascualr Research Center, University of Missouri, Columbia, USA Description: Inaugural Dean Franklin Dinner celebrated the work of Professor dean Franklin, the seminal inventor and implementer of ultrasound in experimental physiology and medical diagnostic untrasound |
2007 |
Isaac Newton at the Graduation Ceremony. For Biomedical Science and others, University of Newcastle, Australia, 2007 Organisation: University of Newcastle, Australia Description: This was the invited Occasional Address to graduands of the Faculty of Health Sciences on 17 April, 2007, in the Great Hall, attended by some 1231 residents of Newcastle in the body of the Hall, > 150 graduating students, and 50 staff on the Stage |
1995 |
Education for Change; The Surgical University of Australia. General Scientific Meeting, Royal Australasian College of Surgeons, Perth, Australia Organisation: Royal Australasian College of Surgeons Description: Invited address to the General Scientific Meeting, Royal Australasian College of Surgeons, Perth, 1995. Concerning the evolving the Royal College into a Surgical University. |
Participant
Year | Title / Rationale |
---|---|
1980 |
External Assessor for Chair. Cardiac Surgery, University of Melbourne Organisation: University of Melbourne Description: University requested external Opinion on capability of Applicants |
1980 |
External Assessor for Chair. Pathology, Otago University, New Zealand Organisation: Otago University |
1980 |
External Assessor for Chair. Physiology, University of Tasmania Organisation: Univerity of Tasmania |
1980 |
External Assessor for Chair. Physiology, University of New England , NSW Organisation: University of New England |
1980 |
External Assessor for Chair. General Surgery, University of Western Australia. Organisation: University of Western Australia |
1980 |
External assessor of Chair. Pathology, University of Kuwait, Kuwait Organisation: University of Kuwait |
1980 |
External Assessor for Chair. Physiology, University of Malaya, Kuala Lumpur, Malaysia Organisation: University of Malaya |
1980 |
External Assessor for Chair. Physiology, University of Sains Malaysia, Pulau Pinang, Malaysia Organisation: University of Sains Malaysia, Malaysia |
1980 |
External Assessor for Several Chairs. University of California, Davis, USA : Cardiovascular Medicine, Pulmonary Medicine and Anaesthesiology and Pain Medicine Organisation: University of California, Davis, California |
1980 |
External Assessor for Chair. Medicine, University of California, Irvine, California Organisation: University of California, Irvine |
Speaker
Year | Title / Rationale |
---|---|
2008 |
Reflex controls underpinning asthma syndromes: the Airways Internal Diameter Assessment (AIDA) ultrasonic system for measuring continuous, online changes in airways dimensions and blood flow at rest. Organisation: John M. Dalton Cardiovascular Research Center, University of Missouri, Columbia, USA Description: Celebration of the work of Professor Dean Franklin, with whom I worked in 1969 on Tranlational physiology of the coronary circulation, naspharyngeal reflexes and ultrasonic measurement systems in medical physiology. The Invited Lecture advised on new developments of the original systems applied to the airways blood flow and dimension measurements. |
2007 |
A Reasonable Man. The death of JHA Stacy, Grazier, Athlete and Family Man, All Saints Church, Singleton, The Hunter Valley, NSW Organisation: The Stacy Family |
1999 |
God, Nerves and the Coronary Circulation. The Stengert Memorial Lecture. UC, Davis, USA Organisation: School of Medicine, University of California, Davis, California Description: 10th Annual Stengert Lecture. In honour of Krzysztof Stengert, Former Chief of Cardiovascular Anaesthesia, School of Medicine, University of California, Davis, USA |
1992 |
The New Science of Exercise: the Invited Lecture, Australian Physiological Society Organisation: Australian Physiological Society- The Invited Lecture Description: Council of Aust Phys Soc invites member to give prestigious lecture on members current research |
1987 |
Eulogy for a Happy Warrior. The death of Peter Fenwicke, Grazier, King's School Old Boy, and Wallaby Captain. Organisation: St Andrew's Anglican Church, Walcha, New South Wales Description: Peter Fenwicke was an athlete and leader. He captained Australia at Rugby on a tour to New Zealand, was a fine cricketer and tennis player. But above all he was a family man and grazier of the traditional Australian mould. |
Publications
For publications that are currently unpublished or in-press, details are shown in italics.
Book (2 outputs)
Year | Citation | Altmetrics | Link |
---|---|---|---|
1991 | Laura RS, White SW, Drug Controversy in Sport: The Socio-Ethical and Medical Issues, Allen & Unwin, North Sydney, NSW, 171 (1991) | ||
1987 | Brinsmead M, White SW, Learning for Change in Medical Practice: Proceedings of the Annual Forum, the Australian Postgraduate Federation in Medicine (Newcastle N.S.W, 12th-13th May 1987), Hunter Postgraduate Medical Institute, Newcastle, NSW, 80 (1987) | Nova |
Chapter (7 outputs)
Year | Citation | Altmetrics | Link | ||
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1991 | White SW, 'The need for steroids in modern athleticism', Drug Controversy in Sport: The Socio-Ethical and Medical Issues, Allen & Unwin, North Sydney, NSW 80-89 (1991) | Nova | |||
1991 | Laura RS, White SW, 'The price athletes pay in pursuit of Olympic gold', Drug Controversy in Sport: The Socio-Ethical and Medical Issues, Allen & Unwin, North Sydney, NSW 1-14 (1991) | Nova | |||
1988 |
White SW, Moore PG, Gazibarich GJ, Porges WL, Quail AW, 'Central nervous integration of coronary reflexes', Vasodilatation: Vascular Smooth Muscle, Peptides, Autonomic Nerves, and Endothelium, Raven Press, New York 299-306 (1988)
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Nova | |||
Show 4 more chapters |
Journal article (93 outputs)
Year | Citation | Altmetrics | Link | ||||||||
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2022 |
Bournazos AM, Riley LG, Bommireddipalli S, Ades L, Akesson LS, Al-Shinnag M, et al., 'Standardized practices for RNA diagnostics using clinically accessible specimens reclassifies 75% of putative splicing variants', Genetics in Medicine, 24 130-145 (2022) [C1] Purpose: Genetic variants causing aberrant premessenger RNA splicing are increasingly being recognized as causal variants in genetic disorders. In this study, we devise standardiz... [more] Purpose: Genetic variants causing aberrant premessenger RNA splicing are increasingly being recognized as causal variants in genetic disorders. In this study, we devise standardized practices for polymerase chain reaction (PCR)-based RNA diagnostics using clinically accessible specimens (blood, fibroblasts, urothelia, biopsy). Methods: A total of 74 families with diverse monogenic conditions (31% prenatal-congenital onset, 47% early childhood, and 22% teenage-adult onset) were triaged into PCR-based RNA testing, with comparative RNA sequencing for 19 cases. Results: Informative RNA assay data were obtained for 96% of cases, enabling variant reclassification for 75% variants that can be used for genetic counseling (71%), to inform clinical care (32%) and prenatal counseling (41%). Variant-associated mis-splicing was highly reproducible for 28 cases with samples from =2 affected individuals or heterozygotes and 10 cases with =2 biospecimens. PCR amplicons encompassing another segregated heterozygous variant was vital for clinical interpretation of 22 of 79 variants to phase RNA splicing events and discern complete from partial mis-splicing. Conclusion: RNA diagnostics enabled provision of a genetic diagnosis for 64% of recruited cases. PCR-based RNA diagnostics has capacity to analyze 81.3% of clinically significant genes, with long amplicons providing an advantage over RNA sequencing to phase RNA splicing events. The Australasian Consortium for RNA Diagnostics (SpliceACORD) provide clinically-endorsed, standardized protocols and recommendations for interpreting RNA assay data.
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Nova | |||||||||
2022 |
Thavanesan N, White S, Lee S, Ratnayake B, Oppong KW, Nayar MK, et al., 'Analgesia in the Initial Management of Acute Pancreatitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials', WORLD JOURNAL OF SURGERY, 46 878-890 (2022) [C1]
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2022 |
Kamarajah SK, Al-Rawashdeh W, White SA, Abu Hilal M, Salti GI, Dahdaleh FS, 'Adjuvant radiotherapy improves long-term survival after resection for gallbladder cancer A population-based cohort study', European Journal of Surgical Oncology, 48 425-434 (2022) [C1] Background: Data supporting routine use of adjuvant radiotherapy (RT) compared to without RT (noRT) for gallbladder cancer (GBC) is unclear. This study aimed to determine whether ... [more] Background: Data supporting routine use of adjuvant radiotherapy (RT) compared to without RT (noRT) for gallbladder cancer (GBC) is unclear. This study aimed to determine whether RT improves long-term survival following resection for GBC. Methods: Patients receiving resection for GBC followed by RT from 2004 to 2016 were identified from the National Cancer Database (NCDB). Patients with survival <6 months were excluded to account for immortal time bias. Propensity score matching (PSM) and Cox regression was performed to account for selection bias and analyze impact of RT on overall survival. Results: Of 7514 (77%) noRT and 2261 (23%) RT, 2067 noRT and 2067 RT patients remained after PSM. After matching, RT was associated with improved survival (median: 26.2 vs 21.5 months, p < 0.001), which remained after multivariable adjustment (HR: 0.82, CI95%: 0.76¿0.89, p < 0.001). On multivariable interaction analyses, this benefit persisted irrespective of nodal status: N0 (HR: 0.84, CI95%: 0.77¿0.93), N1 (HR: 0.77, CI95%: 0.68¿0.88), N2/N3 (HR: 0.56, CI95%: 0.35¿0.91), margin status: R0 (HR: 0.85, CI95%: 0.78¿0.93), R1 (HR: 0.78, CI95%: 0.68¿0.88) and use of adjuvant chemotherapy (AC) (HR: 0.67, CI95%: 0.57¿0.79). Benefit with RT were also seen in patients with T2 - T4 disease and in patients undergoing simple and extended cholecystectomy. Conclusion: RT following resection was associated with improved survival in this study, even in margin-negative and node-negative disease. These findings may suggest addition of RT into multimodality therapy for GBC.
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2022 |
Kamarajah S, Sutandi N, Sen G, Hammond J, Manas D, French J, White S, 'Comparative analysis of open, laparoscopic and robotic distal pancreatic resection: The United Kingdom's first single-centre experience', Journal of Minimal Access Surgery, 18 77-83 (2022) [C1] Introduction: Laparoscopic distal pancreatectomy (LDP) has potential advantages over its open equivalent open distal pancreatectomy (ODP) for pancreatic disease in the neck, body ... [more] Introduction: Laparoscopic distal pancreatectomy (LDP) has potential advantages over its open equivalent open distal pancreatectomy (ODP) for pancreatic disease in the neck, body and tail. Within the United Kingdom (UK), there has been no previous experience describing the role of robotic distal pancreatectomy (RDP). This study evaluated differences between ODP, LDP and RDP. Methods: Patients undergoing distal pancreatectomy performed in the Department of Hepatobiliary and Pancreatic Surgery at the Freeman Hospital between September 2007 and December 2018 were included from a prospectively maintained database. The primary outcome measure was length of hospital stay, and the secondary outcome measures were complication rates graded according to the Clavien-Dindo classification. Results: Of the 125 patients, the median age was 61 years and 46% were male. Patients undergoing RDP (n = 40) had higher American Society of Anesthesiologists grading III compared to ODP (n = 38) and LDP (n = 47) (57% vs. 37% vs. 38%, P = 0.02). RDP had a slightly lower but not significant conversion rate (10% vs. 13%, P = 0.084), less blood loss (median: 0 vs. 250 ml, P < 0.001) and a higher rate of splenic preservation (30% vs. 2%, P < 0.001) and shorter operative time, once docking time excluded (284 vs. 300 min, P < 0.001) compared to LDP. RDP had a higher R0 resection rate than ODP and LDP (79% vs. 47% vs. 71%, P = 0.078) for neoplasms. RDP was associated with significantly shorter hospital stay than LDP and ODP (8 vs. 9 vs. 10 days, P = 0.001). While there was no significant different in overall complications across the groups, RDP was associated with lower rates of Grade C pancreatic fistula than ODP and LDP (2% vs. 5% vs. 6%, P = 0.194). Conclusion: Minimally invasive pancreatic resection offers potential advantages over ODP, with a trend showing RDP to be marginally superior when compared to conventional LDP, but it is accepted that that this is likely to be at greater expense compared to the other current techniques.
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2022 |
Ahmed WUR, Bhatia S, McLean KA, Khaw R, Baker D, Kamarajah SK, et al., 'Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery', BJS OPEN, 6 (2022) [C1]
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2016 |
Khoshdel AR, Carney S, White S, Gillies A, 'Hemodynamic response to exercise for prediction of development of kidney failure revealing a cardiorenal secret cross talk', Iranian Journal of Kidney Diseases, 10 282-290 (2016) [C1] Introduction. Kidney disease increases the risk of cardiovascular disease. The corollary of that observation should be that cardiovascular disease would not only increase the risk... [more] Introduction. Kidney disease increases the risk of cardiovascular disease. The corollary of that observation should be that cardiovascular disease would not only increase the risk of kidney dysfunction, but also cause kidney damage, a concept not previously proposed. Materials and Methods. Hemodynamic response to a graded exercise stress test was measured in 70 candidates to evaluate the association of heart rate and blood pressure change, heart rate reserve, chronotropic incompetence (percentage of achievement of maximal predicted heart rate), and circulatory power with development of kidney failure (glomerular filtration rate < 30 mL/ min/1.73 m2) during 123 months of follow-up period. Results. Kidney failure was more likely to develop in patients with lower heart rate change, heart rate reserve, percentage of achievement of maximal predicted heart rate, and circulatory power (P =.002, P =.01, P =.02, and P =.008, respectively), even after adjustment for age, resting pulse pressure, hypertension, diabetes mellitus, and exercise test result (hazard ratios, 5.9, 2.9, 3.3, and 2.9, respectively). A resting pulse pressure of 60 mm Hg and higher was accompanied by 7.4 times (95% confidence interval, 1.8 to 30.9) greater risk of developing kidney failure, independent of age and resting systolic blood pressure (P =.006). Conclusions. Hemodynamic responses to a standard graded exercise stress test independently predicted the development of kidney failure. Also, arterial stiffness (represented by resting pulse pressure) could be a factor linking ventricular and kidney function. Early diagnosis of kidney disease should include a cardiovascular assessment and vice versa.
|
Nova | |||||||||
2012 |
McLeod DD, Parsons G, Gunther R, Quail AW, Cottee DB, White SW, 'Differential effects of inhaled methacholine on circumferential wall and vascular smooth muscle of third-generation airways in awake sheep', Journal of Applied Physiology, 113 1233-1242 (2012) [C1]
|
Nova | |||||||||
2011 |
McIlveen SA, White SW, Quail AW, McLeod DD, Parsons G, 'Integration of baroreflex and autoregulation control of bronchial blood flow in awake dogs', Acta Physiologica, 203 299-310 (2011) [C1]
|
Nova | |||||||||
2007 |
Parsons G, White SW, Quail AW, McIlveen SA, Bishop R, McLeod DD, et al., 'Autonomic control of bronchial blood flow and airway dimensions during strenuous exercise in sheep', Pulmonary Pharmacology & Therapeutics, 20 190-199 (2007) [C1]
|
Nova | |||||||||
2007 |
Bishop R, McLeod DD, McIlveen SA, Blake RJ, Gunther R, Davis J, et al., 'Effects of graded exercise on bronchial blood flow and airway dimensions in sheep', Pulmonary Pharmacology & Therapeutics, 20 178-189 (2007) [C1]
|
Nova | |||||||||
2007 |
Khoshdel A, Carney SL, White SW, 'Disturbed hemodynamic cardiac exercise stress test response in non-smoking, normolipidemic, normotensive, diabetic subjects', Diabetes Research and Clinical Practice, 75 193-199 (2007) [C1]
|
Nova | |||||||||
2003 |
Quail AW, Cottee DB, McLeod DD, Blake RJ, Bishop R, McIlveen SA, White SW, 'Analysis of Bronchovascular Downstream Blood Pressure Changes in Exercising Sheep', Archives of Physiology and Biochemistry, 111 309-313 (2003) [C1]
|
Nova | |||||||||
2003 |
Bishop R, McLeod DD, McIlveen SA, Blake RJ, Gunther R, Davis J, et al., 'Long-Term Measurement of Bronchial Vascular Resistance in Awake Sheep and Dogs', Archives of Physiology and Biochemistry, 111 315-315 (2003) [C1]
|
Nova | |||||||||
2003 |
White SW, McIlveen SA, Parsons G, Quail AW, Cottee DB, Gunther R, et al., 'Neural Control of the Bronchial Circulation', Archives of the Physiology and Biochemistry, 111 305-308 (2003) [C1]
|
Nova | |||||||||
2001 |
White S, Pitsillides K, Parsons G, Hayes S, Gunther R, Cottee DB, 'Coronary-bronchial blood flow and airway dimensions in exercise-induced syndromes', Clinical and Experimental Pharmacology and Physiology, 28 472-478 (2001) [C1]
|
Nova | |||||||||
2000 |
Newman DG, White SW, Callister R, 'The effect of baroreflex adaptation on the dynamic cardiovascualr response to head-up tilt', Aviation, Space, and Environmental Medicine, 71(3) 255-259 (2000) [C1]
|
Nova | |||||||||
2000 |
Porges W, Hennessy E, Quail AW, Cottee D, Moore P, McIlveen SA, et al., 'Heart-Lung Interactions: The sigh and autonomic control in the bronchial and coronary circulations', Clinical and Experimental Pharmacology and Physiology, 27 1022-1027 (2000) [C1]
|
Nova | |||||||||
2000 |
Quail AW, Cottee D, Porges W, White SW, 'Recent views on integrated coronary control: significance of non-uniform regional control of coronary flow conductance', Clinical and Experimental Pharmacology and Physiology, 27 1039-1044 (2000) [C1]
|
Nova | |||||||||
2000 |
Cottee D, Quail AW, Porges W, Moore P, White SW, 'Effects of anaesthesia on regional coronary control mechanisms', Clinical and Experimental Pharmacology and Physiology, 27 1034-1038 (2000) [C1]
|
Nova | |||||||||
2000 |
Moore P, Quail AW, Cottee D, McIlveen SA, White SW, 'Effect of fentanyl on baroreflex control of circumflex coronary conductance', Clinical and Experimental Pharmacology and Physiology, 27 1028-1033 (2000) [C1]
|
Nova | |||||||||
1999 |
Bandaranayake R, Payne S, White SW, 'Using multiple response true-false multiple choice questions', The Australian and New Zealand Journal of Surgery, 69 311-315 (1999) [C1]
|
Nova | |||||||||
1999 |
Newman DG, White SW, Callister R, 'Patterns of Physical Conditioning in Royal Australian Air Force F/A-18 Pilots and the Implications for +Gz Tolerance', Aviation, Space, and Environmental Medicine, 70: 8 739-744 (1999) [C1]
|
Nova | |||||||||
1999 |
Buckner PS, Quail AW, Cottee DB, White SW, 'Venous hydrostatic indifference point as a marker of postnatal adaptation to orthostasis in swine', Journal of Applied Physiology, 87 882-888 (1999) [C1]
|
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1998 |
Newman DG, White SW, Callister R, 'Evidence of Baroreflex Adaptation to Repetitive +Gz in Fighter Pilots', Aviation, Space, and Environmental Medicine, 69(5) 446-451 (1998) [C1]
|
Nova | |||||||||
1998 |
White SW, 'Integrated baroreflex control of regional coronary blood flow', Cardiologia, 43(6) 559-570 (1998) [C1]
|
Nova | |||||||||
Show 90 more journal articles |
Conference (59 outputs)
Year | Citation | Altmetrics | Link | ||||
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2021 | Thavanesan N, White S, Lee S, Ratnayake B, Leeds J, Nayar M, et al., 'Towards effective analgesia in acute pancreatitis: a systematic review of randomised controlled trials', BRITISH JOURNAL OF SURGERY (2021) | ||||||
2017 |
Quail AW, Cottee DBF, Johnstone JM, O'Hara K, White SW, 'Cardiorespiratory Responses to Severe Arterial Hypoxemia with Increasing Remifentanil Plasma Concentrations in the Rabbit', FASEB JOURNAL, Chicago, IL (2017)
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2016 |
Quail AW, Conee DB, MareeJohnstone J, White SW, 'The Effects of Remifentanil on the Cardiorespiratory Responses to Severe Arterial Hypoxia in the Rabbit', FASEB JOURNAL, San Diego, CA (2016)
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2013 |
White SW, Cottee DB, Quail AW, 'The cyanosed myocardium: evolutionary defence against reflex coronary vasoconstriction in vertebrates including man', Proceedings of the Australian Physiological Society, Geelong, Victoria (2013) [E3]
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2013 |
Quail AW, Cottee DB, Roach R, White SW, 'Central modulation of arterial chemo-baroreflex control by propofol during severe arterial hypoxia in the rabbit', The FASEB Journal, - (2013) [E3]
|
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2012 |
Quail AW, Cottee DB, Roach RE, White SW, 'Propofol selectively modifies the arterial chemoreflex during severe hypoxia in the rabbit', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
|
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2012 |
White SW, McLeod DD, Parsons G, Gunther R, Cottee DB, Quail AW, 'Selective effects of inhaled methacholine on 3rd generation bronchial blood flow and airway dimensions in awake sheep', FASEB Journal, San Diego, CA (2012) [E3]
|
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2012 |
Quail AW, Cottee DB, McLeod DD, Hamut M, White SW, 'Comparative effects of isoflurane, sevoflurane and desflurane on resting airway dimensions in the sheep', ANZCA ASM 2012. Evolution: Grow Develop Thrive: ePoster Sessions 2012, Perth, WA (2012) [E3]
|
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2011 |
White SW, McLeod DD, Parsons GH, Gunther RA, Cottee DB, Quail AW, 'Inhaled and intravenous methacholine evoke differential effects on bronchial blood flow and 3rd generation airway dimensions in awake sheep', Proceedings of the Australian Physiological Society 2011, Perth (2011) [E3]
|
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2011 |
Hamut M, Quail AW, Seah PW, McLeod DD, Cottee DB, White SW, 'Mammalian differences in vagal-cholinoceptor control of coronary conductance', The FASEB journal, Washington, DC (2011) [E3]
|
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2009 | White SW, 'Cholinoreceptor control differences do exist in the coronary circulation of mammals', ISAN Satellite Meeting. Autonomic Adjustments to Environmental Challenges. Final Program, Newcastle, NSW (2009) [E3] | ||||||
2008 |
McLeod DD, Gunther R, Seah PW, Quail AW, Cottee DB, Parsons G, White SW, 'Integrated autonomic control of the bronchial circulation and 3rd generation bronchus in the exercising sheep', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
|
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2008 |
Hamut M, Quail AW, Cottee DB, Seah PW, McLeod DD, Blake RJ, White SW, 'Effects of evoked acute and steady-state high blood pressure on control of right and left coronary blood flow and conductance in awake sheep', Journal of Hypertension, Berlin, Germany (2008) [E3]
|
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2008 |
White SW, McIlveen SA, Quail AW, Parsons G, 'Control of lower airway blood flow during acute and sustained arterial pressure in mammalian species', Journal of Hypertension, Berlin, Germany (2008) [E3]
|
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2007 |
Robinson S, McLeod DD, Gunther R, Quail AW, White SW, Parsons G, 'High frequency oscillatory ventilation (HFOV) effects on airway blood flow and airway caliber in sheep', American Journal of Respiratory and Critical Care Medicine, San Francisco, Calif. (2007) [E3]
|
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2007 |
McLeod DD, Robinson S, Gunther R, Quail AW, Cottee DB, Seah P, et al., 'Effects of graded PEEP on bronchial blood flow and dimensions', American Journal of Respiratory and Critical Care Medicine, San Francisco, Calif. (2007) [E3]
|
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2007 |
Hamut M, Quail AW, Cottee DB, Seah PW, McLeod DD, Blake RJ, White SW, 'Baroreflex-autonomic control of regional coronary blood flow conductance in awake sheep', Proceedings of the Australian Physiological Society, Newcastle, N.S.W. (2007) [E3]
|
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2007 |
White SW, Parsons G, MacTaggart G, McLeod DD, Hamut M, Cottee DB, Quail AW, 'Controversy: Exercise-induced pulmonary haemorrhage in the horse', Proceedings of the Australian Physiological Society, Newcastle, N.S.W. (2007) [E3]
|
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2007 |
McLeod DD, Gunther R, Seah PW, Quail AW, Cottee DB, Parsons G, White SW, 'Integrated autonomic control of the bronchial circulation and 3rd generation airway dimensions during exercise in awake sheep', Proceedings of the Australian Physiological Society, Newcastle, N.S.W. (2007) [E3]
|
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2007 |
Quail AW, Cottee DB, Seah PW, McLeod DD, Blake RJ, White SW, 'Evolutionary aspects of neural control of coronary blood flow', Proceedings of the Australian Physiological Society, Newcastle, N.S.W. (2007) [E3]
|
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2006 |
McLeod DD, Bastian F, Parsons G, Gunther R, Quail AW, Cottee DB, White SW, 'Graded exercise evokes bronchovascular and lower airway smooth muscle constriction', Abstracts from AuPS/Combio Brisbane 2006 (Proceedings of the Australian Physiological Society Vol 37), Brisbane (2006) [E3]
|
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2006 |
White SW, McLeod DD, McIlveen SA, Bishop R, Gunther R, Cottee DB, Parsons G, 'Autonomic control of bronchial blood flow, airway circumference and airway wall thickness during strenuous exercise in sheep (Poster presentation)', Abstracts of the Experimental Biology 2006 Meeting (FASEB Journal vol 20, no 5), San Francisco, CA (2006) [E3]
|
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2006 |
McLeod DD, Parsons G, Bishop R, McIlveen SA, Gunther R, Cottee DB, et al., 'Effects of graded exercise on bronchial blood flow and airway dimensions in sheep', Experimental Biology 2006: Meeting Abstracts, San Francisco (2006) [E3]
|
||||||
2006 |
Hamut M, Quail AW, Cottee DB, Seah PW, Blake RJ, White SW, et al., 'Development of a chronic sheepp model for the study of regional coronary control mechanisms', Experimental Biology 2006: Meeting Abstracts, San Francisco (2006) [E3]
|
||||||
2006 | Khoshdel A, Carney SL, White SW, 'Disturbed hemodynamic cardiac exercise stress test response in non-smoking, normolipidemic, normotensive, diabetic subjects', Heart Foundation Conference and Scientific Meeting, Sydney (2006) [E3] | ||||||
2006 |
White SW, McLeod DD, Parsons G, Gunther R, McIlveen SA, Bishop R, et al., 'Autonomic control of airways vascular and wall smooth muscle during exercise', Proceedings of the Australian Physiological Society, Brisbane (2006) [E3]
|
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2005 |
McLeod DD, Parsons G, Gunther R, McIlveen SA, Bishop R, White SW, et al., 'Neural factors controlling bronchial blood flow during exercise', The FASEB Journal, San Diego, USA (2005) [E3]
|
||||||
2005 |
Roach RE, Quail AW, Cottee DB, Blake RJ, White SW, 'Propofol selectively modifies respiratory patterning during severe arterial hypoxia in the rabbit', The FASEB Journal, San Diego, USA (2005) [E3]
|
||||||
2004 |
White SW, McIlveen SA, Bishop R, McLeod DD, Blake RJ, Gunther R, et al., 'Mechanisms controlling airways circulation during exercise', Proccedings of the Australian Health and Medical Research Congress 2004, Sydney (2004) [E3]
|
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2004 |
Quail AW, Cottee DB, McLeod DD, Blake RJ, Bishop R, McIlveen SA, et al., 'Neural and pressure gradient factors controlling bronchial blood flow in exercising sheep', -, Royal North Shore Hospital, Sydney (2004) [E1]
|
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2003 |
Quail AW, Moore PG, Cottee DB, White SW, 'Differential Response of Canine Left Coronary Beds to Calcitonin Gene-Related Peptide and Adenosine', Heat Lung & Circulation, Sydney (2003) [E3]
|
||||||
1999 |
Quail AW, Cottee DB, Porges W, White SW, 'Effects of Nitric Oxide Synthase Inhibition on Regional Coronary Flows in the Conscious Dog', Australian & NZ College of Anaesthetists, Faculty of Intensive Care, Faculty of Pain Medicine, Annual Scientific Meeting, Abstracts & Scientific Programme, Adelaide '99 (1999) [E2]
|
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1999 | White SW, Pitsllides K, Parsons G, 'Airways Internal Diameter Assessment (AIDA)Sonomicrometer: A Novel Instrument for the Continuous Measurement of Airways Dimensions and Blood Flow in Awake Animals', Proceedings of the Australian Physiological and Pharmacological Society, Newcastle, Australia (1999) [E2] | ||||||
1999 |
Cottee DB, 'Effects of Anaesthesia on Coronary Control Mechanisms', Proceedings of the Australian Physiological and Pharmacological Society, Newcastle, Australia (1999) [E2]
|
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1999 |
White SW, McIlveen SA, Reitan J, Quail AW, Cottee DB, Porges W, 'Cardiac Sensory Control of Bronchial Blood Flow', The FASEB Journal, Washington, USA (1999) [E2]
|
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1999 |
Quail AW, Cottee DB, McIlveen T, McIlveen SA, Glenfield PJ, Porges W, White SW, 'Vagal Control of Coronary Circulations: Lack of Differential Effects of Nitric Oxide on Net Flow Conductance Between Right, Circumflex and Anterior Descending Beds', The FASEB Journal, Washington, USA (1999) [E2]
|
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Show 56 more conferences |
Thesis / Dissertation (1 outputs)
Year | Citation | Altmetrics | Link |
---|---|---|---|
1967 | White SW, Reflex and local aspects of cardiovascular control in the unanaesthetized rabbit, UNSW (1967) |
Grants and Funding
Summary
Number of grants | 35 |
---|---|
Total funding | $1,056,521 |
Click on a grant title below to expand the full details for that specific grant.
20081 grants / $1,700
Celebration of late Professor Dean Franklin, DIrector, John Dalton Cardiovascular Research Centre, University of Missouri, Colombia, USA, John Dalton Centre, 11/9/2008 - 12/9/2008$1,700
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Emeritus Professor Saxon White |
Scheme | Travel Grant |
Role | Lead |
Funding Start | 2008 |
Funding Finish | 2008 |
GNo | G0189410 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20011 grants / $129,000
Hunter Heart-Lung Research Guild$129,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Emeritus Professor Saxon White |
Scheme | NSW Dept Health - Infrastructure Funding |
Role | Lead |
Funding Start | 2001 |
Funding Finish | 2003 |
GNo | G0183309 |
Type Of Funding | Contract - Aust Non Government |
Category | 3AFC |
UON | Y |
20001 grants / $15,000
Continuous Measurement of Airways Circumference, Thickness and Blood Flow.$15,000
Funding body: Ramaciotti Foundations
Funding body | Ramaciotti Foundations |
---|---|
Project Team | Emeritus Professor Saxon White |
Scheme | Research Grant |
Role | Lead |
Funding Start | 2000 |
Funding Finish | 2000 |
GNo | G0178725 |
Type Of Funding | Aust Competitive - Non Commonwealth |
Category | 1NS |
UON | Y |
19981 grants / $2,385
American Thoracic Society International Conference, Chicago, USA$2,385
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Emeritus Professor Saxon White |
Scheme | Travel Grant |
Role | Lead |
Funding Start | 1998 |
Funding Finish | 1998 |
GNo | G0180627 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
19971 grants / $1,600
Business Meeting of da Vinci Society, California, USA, 16-21 May 1997$1,600
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Emeritus Professor Saxon White |
Scheme | Travel Grant |
Role | Lead |
Funding Start | 1997 |
Funding Finish | 1997 |
GNo | G0179601 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
19952 grants / $4,458
3rd International Symposium on Airway Circulation in Health and Disease (Interaction between airway vasculature and pulmonary smooth muscles - France - 12-14 Se$2,500
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Emeritus Professor Saxon White |
Scheme | Travel Grant |
Role | Lead |
Funding Start | 1995 |
Funding Finish | 1995 |
GNo | G0175613 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
American Thoracic Society, Seattle, USA, 21-24 May$1,958
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Emeritus Professor Saxon White |
Scheme | Travel Grant |
Role | Lead |
Funding Start | 1995 |
Funding Finish | 1995 |
GNo | G0176862 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
19942 grants / $165,391
Sino-Aortic and Cardiac Receptor Control of Bronchial and Coronary Circulations.$151,139
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Emeritus Professor Saxon White, Conjoint Professor Tony Quail |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1994 |
Funding Finish | 1996 |
GNo | G0173025 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
94 GRANT. Regulation of muscle synmpathetic nerve activity at the onset of exercise in humans$14,252
Funding body: Ramaciotti Foundations
Funding body | Ramaciotti Foundations |
---|---|
Project Team | Emeritus Professor Robin Callister, Conjoint Professor Tony Quail, Emeritus Professor Saxon White |
Scheme | Research Grant |
Role | Investigator |
Funding Start | 1994 |
Funding Finish | 1994 |
GNo | G0173374 |
Type Of Funding | Aust Competitive - Non Commonwealth |
Category | 1NS |
UON | Y |
19911 grants / $50,000
The effects of nebivolol on perceived exertion and cardiac output in hypertensive patients under conditions of rest and graded exercise$50,000
Funding body: Janssen Cilag Pty Ltd
Funding body | Janssen Cilag Pty Ltd |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1991 |
Funding Finish | 1991 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
19901 grants / $188,584
Studies on the Thoracic Circulations: Control of Bronchial and Coronary Conductance$188,584
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Emeritus Professor Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1990 |
Funding Finish | 1992 |
GNo | G0173961 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
19882 grants / $7,300
Series and parallel coupled neural controls of the coronary circulation: effcets of alcohol and other addicting drugs on behavioural and baroreceptor reflex gains$4,000
Funding body: University of Newcastle Research Committee
Funding body | University of Newcastle Research Committee |
---|---|
Project Team | Saxon White |
Scheme | Project Seeding Grant |
Role | Lead |
Funding Start | 1988 |
Funding Finish | 1988 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
Emotional behaviour and the coronary circulation$3,300
Funding body: Faculty Research Committee
Funding body | Faculty Research Committee |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1988 |
Funding Finish | 1988 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
19874 grants / $147,429
Behavioural, reflex and local control of the bronchial circulation$105,100
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1987 |
Funding Finish | 1989 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
Arterial preasure and steroidal hormonal changes in men and women during exercise and in post-exercise state$20,629
Funding body: National Heart Foundation of Australia
Funding body | National Heart Foundation of Australia |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1987 |
Funding Finish | 1987 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
Role of beta-blockade in the fatigue of exercise$18,400
Funding body: ICI
Funding body | ICI |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1987 |
Funding Finish | 1988 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
Dynamic coronary flow distribution patterns and their control in ischaemic heart disease and hypertension$3,300
Funding body: Clive & Vera Ramaciotti
Funding body | Clive & Vera Ramaciotti |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1987 |
Funding Finish | 1987 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
19861 grants / $7,641
Dynamic coronary flow distribution patterns and their control in ischaemic heart disease and hypertension$7,641
Funding body: Clive & Vera Ramaciotti
Funding body | Clive & Vera Ramaciotti |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1986 |
Funding Finish | 1986 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
19852 grants / $98,748
Functional mapping of CNS control of coronary conductance in the dog$77,148
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1985 |
Funding Finish | 1986 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
Evaluative study of fitness programs in specific subgroups of the population$21,600
Funding body: HCF Health and Medical Research Foundation
Funding body | HCF Health and Medical Research Foundation |
---|---|
Project Team | Saxon White and Wendy Brown |
Scheme | Research Grant |
Role | Lead |
Funding Start | 1985 |
Funding Finish | 1986 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
19841 grants / $9,248
Cardiorespiratory, metabolic and sex hormone response relationships in exercising prepubescent children$9,248
Funding body: Menzies Foundation
Funding body | Menzies Foundation |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1984 |
Funding Finish | 1984 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
19831 grants / $800
Effects of low frequency weak electric and magnetic oscillations on the mammalian cardiovascular system$800
Funding body: IRAC
Funding body | IRAC |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1983 |
Funding Finish | 1983 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
19822 grants / $94,526
CNS control of baroreflex regulation of coronary conductance$82,526
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1982 |
Funding Finish | 1983 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
Evaluation of perfusion monitor$12,000
Funding body: Kendall
Funding body | Kendall |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1982 |
Funding Finish | 1982 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
19811 grants / $42,607
Substance P and enkephalins in reflex cardiopulmonary control$42,607
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1981 |
Funding Finish | 1982 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
19802 grants / $32,742
Central neurotransmitter regulation of thermoregulatory reflexes in the conscious rabbit$31,042
Funding body: IRAC
Funding body | IRAC |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1980 |
Funding Finish | 1981 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
Central control of cardiopulmonary function by opiate receptors: neural and non-neural CV effects of new anaesthesia induction agents in man$1,700
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1980 |
Funding Finish | 1980 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
19793 grants / $3,200
Sex differences in metabolism in endurance exercise$2,000
Funding body: Faculty Research Committee
Funding body | Faculty Research Committee |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1979 |
Funding Finish | 1979 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
Central neurotransmitter regulation of thermoregulatory reflexes in the conscious rabbit$700
Funding body: IRAC
Funding body | IRAC |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1979 |
Funding Finish | 1979 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
Endurance exercise studies$500
Funding body: University Research Committee
Funding body | University Research Committee |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1979 |
Funding Finish | 1979 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
19782 grants / $9,300
Neural and non-neural cardiovascular effects of new anaesthesia induction agents in man$6,300
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1978 |
Funding Finish | 1979 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
Central neurotransmitters and Thermoregulatory cardiovascular reflexes$3,000
Funding body: Faculty Research Committee
Funding body | Faculty Research Committee |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1978 |
Funding Finish | 1978 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
19771 grants / $10,980
Role of central monoaminergic neurones in control of cerebral and peripheral regional blood flow$10,980
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1977 |
Funding Finish | 1977 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
19751 grants / $30,192
Role of central monoaminergic neurones in control of cerebral and peripheral regional blood flow$30,192
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1975 |
Funding Finish | 1976 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
19741 grants / $3,690
Control of the coronary circulation in health and disease$3,690
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Saxon White |
Scheme | Project Grant |
Role | Lead |
Funding Start | 1974 |
Funding Finish | 1975 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
Research Supervision
Number of supervisions
Past Supervision
Year | Level of Study | Research Title | Program | Supervisor Type |
---|---|---|---|---|
1998 | PhD | Reflex control of the bronchial circulation | Health, University of Newcastle | Principal Supervisor |
1996 | PhD | Behavioural and autonomic control of the bronchial circulation | Health, University of Newcastle | Principal Supervisor |
1991 | PhD | Modification of resting and baroreflex control of regional coronary blood flow in the awake dog by Isoflurane, Enflurane and Halothane | Health, University of Newcastle | Principal Supervisor |
1990 | PhD | Opioid modulation of baroreflex control of coronary conductance: a study of Fentanyl Anaesthesia | Health, University of Newcastle | Principal Supervisor |
1989 | Honours | Cardioresiratory-endocrine correlates of menstrual irregularity in teenage ballet dancers. | Health, University of Newcastle | Principal Supervisor |
1984 | Honours | Pre-pubescent Children: Hormonal influences on the integrated response to endurance exercise | Health, University of Newcastle | Principal Supervisor |
1984 | PhD | The role of CNS monamines in thermoregulatory and arterial chemoreflex control of cardiopulmonary effectors | Health, University of Newcastle | Principal Supervisor |
1984 | Honours | Prepubertal exercise physiology. The role of sex hormones in regulating substrate utilisation during endurance exercise | Health, University of Newcastle | Principal Supervisor |
1983 | PhD | Endurance Exercise in Man: Metabolic, Cardiorespiratory and Steroid Hormone Correlates in Males and Females | Health, University of Newcastle | Principal Supervisor |
1982 | Honours | Alterations in circulating Oestradiol and other steroid hormones in the male due to exercise. | Health, University of Newcastle | Principal Supervisor |
1982 | Honours | Role of Substance P in arterial chemoreflex control of cardiopulmonary function | Health, University of Newcastle | Principal Supervisor |
1982 | PhD | The Modification of CNS Cardiopulmonary Control by Steroid and Opiate Anaesthetic Agents | Health, University of Newcastle | Principal Supervisor |
1981 | Honours | CNS Substance P in the Rabbit: Studies on distribution and functional significance in relation to cardiopulmonary control | Health, University of Newcastle | Principal Supervisor |
1976 | PhD | Coronary Vascular Response to Raised Aortic Pressure and Changing Ventricular Rate in the Conscious Dog | Health, University of Sydney | Principal Supervisor |
1973 | PhD | Nasopharyngeal Reflexes in the Unanaesthetized Rabbit: an Integrative Analysis of Respiratory and Cardiovascular Effects | Health, University of Sydney | Principal Supervisor |
1973 | Honours | Arterial hypoxia in the unanaesthetized monkey. The relative roles of autonomic and local circulatory mechanisms. | Health, University of Sydney | Principal Supervisor |
1973 | Honours | Modificationof the baroreceptor reflex in the conscious rabbit by Clonidine, an antihypertensive agent. | Health, University of Sydney | Principal Supervisor |
Emeritus Professor Saxon White
Position
Emeritus Professor
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing
Focus area
Human Physiology
Contact Details
saxon.white@newcastle.edu.au | |
Mobile | 0423386509 |
Office
Room | LS2-38 |
---|---|
Building | Life Sciences |
Location | Callaghan University Drive Callaghan, NSW 2308 Australia |