Miss Patrice Jones

Miss Patrice Jones

Casual Academic

School of Environmental and Life Sciences

Career Summary

Biography

Patrice Jones is a PhD candidate at the University of Newcastle with a current research interest in environment-gene interactions in nutrition. Her PhD focuses on our UV-sensitive vitamins, and aims to examine the potential influences our UV-environment and genes may have in modifying the role of these vitamins in health and disease. This involves studying how exposure to UVR may stimulate both the production and degradation of important vitamins, and how genetics may influence how we respond to these vitamins in our diet (nutrigenetics). This research is interdisciplinary and has lead to regular collaborations with researchers in fields of biomedical science, chemistry, physics and anthropology. 

Patrice also works as casual teaching academic within the Faculty of Science as a regular laboratory assistant and lecturer within the Food Science and Human Nutrition program. She is also a growing advocate for science outreach and actively volunteers for opportunities that promote and inspire others down paths in science. Most recently, she has written an article for science-based Lateral Magazine, been a key organiser for Pint of Science Newcastle 2017 and acted as a mentor at University of Newcastle for students considering study in STEMM. 




Qualifications

  • Bachelor of Food Science & Human Nutrition (Hons), University of Newcastle

Keywords

  • Evolutionary Biology
  • Food Science
  • Genetics
  • Nutrigenetics
  • Nutrition

Fields of Research

Code Description Percentage
090899 Food Sciences not elsewhere classified 20
111199 Nutrition and Dietetics not elsewhere classified 40
060499 Genetics not elsewhere classified 40

Professional Experience

UON Appointment

Title Organisation / Department
Casual Academic University of Newcastle
School of Environmental and Life Sciences
Australia
Casual Academic University of Newcastle
School of Environmental and Life Sciences
Australia

Membership

Dates Title Organisation / Department
1/01/2017 -  Student Member Australian Society of Medical Research
Australia
1/01/2016 -  Student Member Nutrition Society Australia
Australia

Awards

Award

Year Award
2016 Faculty Medal
Faculty of Science and Information Technology, University of Newcastle
2016 University Medal
University of Newcastle

Scholarship

Year Award
2016 Research Training Program Stipend Scholarship
Australian Government

Invitations

Committee Member

Year Title / Rationale
2017 Pint of Science (Newcastle)

Contributor

Year Title / Rationale
2017 UoN Alumni Speed Mentor
a

Teaching

Code Course Role Duration
FSHN1020 Foods and Nutrients II
Faculty of Science and Information Technology, University of Newcastle
Laboratory Demonstrator/Occasional Lecturer 1/03/2017 - 30/06/2017
FSHN1010 Foods and Nutrients I
Faculty of Science and Information Technology
Laboratory Demonstrator/Occasional Lecturer 1/07/2017 - 30/11/2017
FSHN2050 Plant Food Products
Faculty of Science and Information Technology, University of Newcastle
Laboratory Demonstrator 1/07/2016 - 30/11/2016
- HSC Experiment Fest - Chemistry
Faculty of Science and Information Technology, University of Newcastle
-
Laboratory Demonstrator 26/06/2017 - 29/06/2017
- HSC Experiment Fest - Chemistry
Faculty of Science and Information Technology, University of Newcastle
Laboratory Demonstrator 27/06/2016 - 30/06/2016
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Highlighted Publications

Year Citation Altmetrics Link
2016 Jones P, Beckett EL, Yates Z, Veysey M, Lucock M, 'Converging Evolutionary, Environmental and Clinical Ideas on Folate Metabolism', Exploratory Research and Hypothesis in Medicine, 1 34-41 (2016) [C1]
DOI 10.14218/ERHM.2016.00003b
Co-authors Mark Lucock, Zoe Yates, Emma Beckett, Martin Veysey

Journal article (8 outputs)

Year Citation Altmetrics Link
2017 Jones P, Lucock M, Veysey M, Jablonski N, Chaplin G, Beckett E, 'Frequency of folate-related polymorphisms varies by skin pigmentation', American Journal of Human Biology, (2017)

© 2017 Wiley Periodicals, Inc. Objectives: Folate-mediated 1-carbon transfer processes are vital in human health but are susceptible to independent and interactive influences of ... [more]

© 2017 Wiley Periodicals, Inc. Objectives: Folate-mediated 1-carbon transfer processes are vital in human health but are susceptible to independent and interactive influences of genetic variance and environmental exposures. Evidence suggests folate levels may be impacted by genetic variance and environmental UVR, with the effect of UVR levels influenced in part by degree of skin pigmentation. Folate-related genes are also influenced by UVR levels; however, the potential relationship between key folate-related genes and skin pigmentation has not yet been explored. The purpose of this study was to examine potential associations between frequencies of key folate variants and degree of skin pigmentation. Methods: Association between population prevalence of 17 variants in 9 folate-related genes (MTRR, MTR, MTHFR, CBS, SHMT1, MTHFD1, RFC1, BHMT, TYMS) and the Fitzpatrick skin phototype of populations was assessed via collation of genotypic data from ALFRED (Allele Frequency Database) and 1000 Genomes databases. Results: A significant association between variant frequency and Fitzpatrick phototype was observed for 16 of 17 examined variants (P < .0029 Bonferroni corrected significance threshold in all cases). Conclusions: These findings demonstrate novel relationships between skin color and folate-related genes, with trends suggesting folate genotypes are selected to maintain homeostasis in the folate system under differing UVR conditions.

DOI 10.1002/ajhb.23079
Co-authors Emma Beckett, Martin Veysey, Mark Lucock
2017 Lucock M, Jones P, Veysey M, Beckett E, 'B vitamins and pollution, an interesting, emerging, yet incomplete picture of folate and the exposome', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114 E3878-E3879 (2017)
DOI 10.1073/pnas.1704662114
Citations Scopus - 1Web of Science - 1
Co-authors Mark Lucock, Emma Beckett, Martin Veysey
2017 Lucock M, Beckett E, Martin C, Jones P, Furst J, Yates Z, et al., 'UV-associated decline in systemic folate: implications for human nutrigenetics, health, and evolutionary processes', AMERICAN JOURNAL OF HUMAN BIOLOGY, 29 (2017) [C1]
DOI 10.1002/ajhb.22929
Citations Scopus - 2Web of Science - 2
Co-authors John Furst, Emma Beckett, Mark Lucock, Martin Veysey, Zoe Yates
2017 Beckett EL, Jones P, Veysey M, Duesing K, Martin C, Furst J, et al., 'VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences', AMERICAN JOURNAL OF HUMAN BIOLOGY, 29 (2017) [C1]
DOI 10.1002/ajhb.23010
Co-authors Zoe Yates, Emma Beckett, Martin Veysey, Mark Lucock, John Furst
2016 Jones P, Beckett EL, Yates Z, Veysey M, Lucock M, 'Converging Evolutionary, Environmental and Clinical Ideas on Folate Metabolism', Exploratory Research and Hypothesis in Medicine, 1 34-41 (2016) [C1]
DOI 10.14218/ERHM.2016.00003b
Co-authors Mark Lucock, Zoe Yates, Emma Beckett, Martin Veysey
2016 Beckett EL, Duesing K, Martin C, Jones P, Furst J, King K, et al., 'Relationship between methylation status of Vitamin D-related genes, Vitamin D levels, and methyl-donor biochemistry', Journal of Nutrition and Intermediary Metabolism, 6 8-15 (2016) [C1]

© 2016 The Authors. Published by Elsevier Inc. Vitamin D is known for its role in the regulation of gene expression via the Vitamin D receptor, a nuclear transcription factor. Mo... [more]

© 2016 The Authors. Published by Elsevier Inc. Vitamin D is known for its role in the regulation of gene expression via the Vitamin D receptor, a nuclear transcription factor. More recently, a role for Vitamin D in regulating DNA methylation has been identified as an additional mechanism of modulation of gene expression. How methylation status influences Vitamin D metabolism and response pathways is not yet clear. Therefore, we aimed to assess the relationship between plasma 25-hydroxycholecalciferol (25(OH)D) and the methylation status of Vitamin D metabolism enzyme genes (CYP2R1, CYP27B1 and CYP24A1) and the Vitamin D receptor gene (VDR). This analysis was conducted in the context of dietary Vitamin D, and background methyl donor related biochemistry, with adjustment for several dietary and lifestyle variables. Percentage methylation at CpG sites was assessed in peripheral blood cells using methylation sensitive and dependent enzymes and qPCR. Standard analytical techniques were used to determine plasma 25(OH)D and homocysteine, and serum folate and B12, with the relationship to methylation status assessed using multi-variable regression analysis. CYP2R1 and VDR methylation were found to be independent predictors of plasma 25(OH)D, when adjusted for Vitamin D intake and other lifestyle variables. CYP24A1 was related to plasma 25(OH)D directly, but not in the context of Vitamin D intake. Methyl-group donor biochemistry was associated with the methylation status of some genes, but did not alter the relationship between methylation and plasma 25(OH)D. Modulation of methylation status of CYP2R1, CYP24A1 and VDR in response to plasma 25(OH)D may be part of feedback loops involved in maintaining Vitamin D homeostasis, and may explain a portion of the variance in plasma 25(OH)D levels in response to intake and sun exposure. Methyl-group donor biochemistry, while a potential independent modulator, did not alter this effect.

DOI 10.1016/j.jnim.2016.04.010
Citations Scopus - 1
Co-authors Mark Lucock, Martin Veysey, Zoe Yates, Katrina King, Emma Beckett, John Furst
2015 Lucock M, Jones P, Martin C, Beckett E, Yates Z, Furst J, Veysey M, 'Vitamin D: Beyond Metabolism', Journal of Evidence-Based Complementary and Alternative Medicine, 20 310-322 (2015) [C1]

© 2015, The Author(s) 2015. Interest in vitamin D and the VDR gene is increasing as putative roles in human health and evolutionary processes are explored. This review looks beyo... [more]

© 2015, The Author(s) 2015. Interest in vitamin D and the VDR gene is increasing as putative roles in human health and evolutionary processes are explored. This review looks beyond the classic biochemistry that links vitamin D to calcium homeostasis; it explores how vitamin D interacts with light in a broader perspective than simple skin photosynthesis. It examines how the vitamin influences circadian rhythm, and how it may have helped drive the evolution of skin pigmentation. To this end, the nutrient¿nutrient relationship with folate is also explored. The VDR gene is additionally examined as a factor in the evolutionary selection of skin depigmentation at higher latitudes to allow vitamin D synthesis. Evidence is given to show that VDR polymorphisms exhibit a latitudinal gradient in allele prevalence consistent with such a paradigm. Overall, the review examines new evo-devo ideas that link light-sensitive vitamins to human health/phenotype, both within and across the lifecycle.

DOI 10.1177/2156587215580491
Citations Scopus - 3
Co-authors Mark Lucock, Zoe Yates, John Furst, Emma Beckett, Martin Veysey
2015 Beckett EL, Martin C, Duesing K, Jones P, Furst J, Yates Z, et al., 'Vitamin D receptor genotype modulates the correlation between vitamin D and circulating levels of let-7a/b and vitamin D intake in an elderly cohort', Journal of Nutrigenetics and Nutrigenomics, 7 264-273 (2015) [C1]
DOI 10.1159/000381676
Citations Scopus - 9Web of Science - 7
Co-authors Mark Lucock, Zoe Yates, Martin Veysey, Emma Beckett, John Furst
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Grants and Funding

Summary

Number of grants 1
Total funding $31,531

Click on a grant title below to expand the full details for that specific grant.


20171 grants / $31,531

Light Sensitive Vitamins - Relationship with Environmental and Genetic Factors$31,531

Funding body: Central Coast Local Health District

Funding body Central Coast Local Health District
Project Team

Mark Lucock, Emma Beckett, Martin Veysey

Scheme Research Grant
Role Investigator
Funding Start 2017
Funding Finish 2020
GNo
Type Of Funding Other Public Sector - State
Category 2OPS
UON N
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Research Collaborations

The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.

Country Count of Publications
Australia 7
United States 3
United Kingdom 2
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Miss Patrice Jones

Positions

Casual Academic
School of Environmental and Life Sciences
Faculty of Science

Casual Academic
School of Environmental and Life Sciences
Faculty of Science

Contact Details

Email patrice.jones@newcastle.edu.au
Links Twitter
Research Networks

Office

Building Science Offices
Location Ourimbah Campus
10 Chittaway Road
Ourimbah, NSW 2258
Australia
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