Dr Nicole Ryan

Dr Nicole Ryan

Postdoctoral Research Fellow

School of Medicine and Public Health (Public Health)

Career Summary

Biography

Dr Nicole M Ryan is a part-time NHMRC Early Career Research Fellow within the Clinical Toxicology Research Centre at The University of Newcastle. The Clinical Toxicology Research Group focuses on improving the understanding of poisoning and envenoming in patients and undertaking studies to determine the effectiveness of antidotes and antivenoms in the treatment of these conditions. Aside from the clinical trials that Dr Ryan leads within the Clinical Toxicology Research Group she also conducts regular ED clinician information and training sessions on the implementation and conduct of these trials within the various research hospital sites. Notably, Dr Ryan’s current toxicology research and earlier refractory cough research have been successfully translated into clinical practice and guidelines.

Dr Ryan is current Convener of the Australian Society for Medical Research (ASMR) Hunter Region Committee for 2016 and 2017 and prior to that co-convener of the Newcastle ASMR 2015 Satellite Scientific Meeting held at HMRI. In conjunction with the Sydney ASMR Committee Convener Dr Ryan continues to raise the profile and importance of ASMR through the recent award of the NSW Government Office of Health and Medical Research Sponsorship of the ASMR Sydney and Newcastle Medical Research Week events for 2017.

Dr Ryan has recently been an invited expert reviewer for the Australian Academy of Science, NOVA: Science for Curious Minds on Venom, a University of Newcastle (UON) undergraduate exam marker and school PhD Confirmation Chair. Dr Ryan represented Early Career Researchers at the Science Pathways 2016: Future Leaders Forum at the UNSW. Dr Ryan has peer-reviewed for ten national and international medical journals within her areas of expertise as well as protocol review for the Dr Hadwen Trust for Humane Research in London. Prior to Dr Ryan’s current post-doctorate appointment in the Clinical Toxicology Research Group she held a NHMRC CCRE PhD scholarship and a post-doctorate position at the Priority Research Centre for Asthma and Respiratory Disease, University of Newcastle and the Hunter Medical Research Institute for 10 years. Dr Ryan has been an invited panel member and advisor at the School’s Thesis by Publication Workshops and was one of the first UON PhD candidates to complete her thesis by publication. For this thesis Dr Ryan was awarded the Faculty of Health & Medicine Research Higher Degree Excellence Award in 2012.

Research Expertise

Dr Ryan’s present and past research has investigated and continues to evolve around neuropathic disorders, where she continues to study their aetiology, mechanisms and investigation of pharmacotherapy treatment trials. Her current research on red-back spider bite envenomation with alternate analgesia such as with medications normally used for neuropathic pain will result in significantly improved ED treatment. Dr Ryan’s research on improving snake bite treatment such as with early antivenom administration and the prophylactic use of corticosteroids for serum sickness are multi-centre randomised placebo controlled-studies that also have the potential to transform treatment for snakebite. These studies form an integral part of the Clinical Toxicology Research Group’s NHMRC CRE for Venom and Antivenom Translation.

Teaching Expertise

Dr Ryan is a co-supervisor of two PhD candidates in the areas of clinical toxinology, toxicology and pharmacology. One of these candidates is examining antidotes and treatments in overdose. This will result in evidence-based management for intensivists and Poisons Information consultants, and best practice guidelines for treatment of medication overdose. Dr Ryan’s other PhD student focuses on the myotoxic effects from Australian and Sri Lankan snakebite. This work builds on a successful collaboration between the Newcastle Clinical Toxicology Research Group and the South Asian Clinical Toxicology Research Collaboration based in Sri Lanka. This research has global significance as snakebite is a recognised WHO Neglected Disease.



Qualifications

  • PhD (Medicine), University of Newcastle
  • Bachelor of Science, University of Newcastle

Keywords

  • Evidence based medicine
  • Medication Effectiveness
  • Science based
  • Snake Envenoming
  • Spider Envenoming
  • Toxicity
  • Toxicology

Fields of Research

Code Description Percentage
111502 Clinical Pharmacology and Therapeutics 40
111506 Toxicology (incl. Clinical Toxicology) 60

Professional Experience

UON Appointment

Title Organisation / Department
Postdoctoral Research Fellow University of Newcastle
School of Medicine and Public Health
Australia

Academic appointment

Dates Title Organisation / Department
1/05/2014 -  NHMRC Early Career Research Fellow

NHMRC - Early Career Fellowships (Formerly Postdoctoral Training Fellowships)

University of Newcastle
Clinical Toxicology Research Group
Australia
1/10/2010 - 1/06/2013 Research Officer University of Newcastle
School of Medicine and Public Health
Australia
1/12/2005 - 1/10/2010 Research PhD Candidate University of Newcastle
School of Medicine and Public Health
Australia

Membership

Dates Title Organisation / Department
1/01/2016 - 31/08/2017 ASMr Hunter Region Committee Convenor

ASMR Hunter Region Committee Convenor

Australian Society for Medical Research (ASMR)
Australia
1/01/2014 - 30/06/2016 Membership - ASMR

Australian Society for Medical Research Committee Member, 2015 Satellite Scientific Meeting Convenor.

Australian Society for Medical Research (ASMR)
Australia

Awards

Research Award

Year Award
2012 HMRI Early Career Travel Award
Unknown
2012 Faculty of Health Research Higher Degree Excellence Award
Unknown
2011 HMRI Pulse Education Prize
Unknown
2008 Finalist 10 of the Best Research Showcase
Unknown

Invitations

Speaker

Year Title / Rationale
2012 Gabapentin for refractory chronic cough: A randomised controlled trial
Organisation: Thoracic Society of Australia and New Zealand Description: CICADA Cough Symposium Invited Speaker
Edit

Grants and Funding

Summary

Number of grants 13
Total funding $310,119

Click on a grant title below to expand the full details for that specific grant.


20173 grants / $41,673

Development of a 3D In Vitro human cell culture system to investigate the mechanism of sudden collapse following snakebite envenoming$22,566

Funding body: University of Sydney

Funding body University of Sydney
Project Team Doctor Nicole Ryan, Dr Erika Bosio, Ms Abbie Francis
Scheme Translational Australian Clinical Toxicology (TACT) Pilot Grant
Role Lead
Funding Start 2017
Funding Finish 2018
GNo G1701192
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Translational Australian Clinical Toxicology (TACT) Program, Pilot Grant$18,052

DEVELOPMENT OF A 3D IN VITRO HUMAN CELL CULTURE SYSTEM TO INVESTIGATE THE MECHANISM OF SUDDEN COLLAPSE FOLLOWING SNAKEBITE ENVENOMING

Funding body: University of Sydney

Funding body University of Sydney
Project Team

Dr Nicole M. Ryan, Dr Erika Bosio, Ms Abbie Francis.

Scheme Translational Australian Clinical Toxicology
Role Lead
Funding Start 2017
Funding Finish 2018
GNo
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON N

NHMRC Translational Australian Clinical Toxicology (TACT) Program, Training and Travel Support Scheme $1,055

Invited speaker at the Toxicology and Poisons Network Association of Australia 2017 Scientific Conference, Melbourne Australia.

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team

Dr Nicole M Ryan

Scheme Partnership Grant
Role Lead
Funding Start 2017
Funding Finish 2017
GNo
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON N

20163 grants / $36,371

Combination Analgesia for Redback spider Envenoming (CARE) Study- A randomised controlled trial$19,966

Funding body: University of Sydney

Funding body University of Sydney
Project Team Doctor Nicole Ryan, Professor Geoff Isbister, Professor Nicholas Buckley, Professor Andis Graudins, Professor Daniel Fatovich
Scheme Translational Australian Clinical Toxicology (TACT) Pilot Grant
Role Lead
Funding Start 2016
Funding Finish 2016
GNo G1501400
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Research Advantage Early Career Researcher Equipment Grant $13,998

Research Advantage Early Career Researcher Equipment Grant 2016 for ‘Frimed Laboratory Freezer with Alarm’. This freezer is used to store research blood samples related to the CI’s research program including patient samples from the Australian Snakebite Project (ASP), the Australian Toxicology Monitoring Study (ATOM) and the international multi-institutional CRE in Venom and Antivenom Translational Research projects.

Funding body: The University of Newcastle - Research and Innovation Division

Funding body The University of Newcastle - Research and Innovation Division
Scheme Research Advantage Funding
Role Lead
Funding Start 2016
Funding Finish 2016
GNo
Type Of Funding Internal
Category INTE
UON N

NHMRC Translational Australian Clinical Toxicology (TACT) Program, Training and Travel Support Scheme (TTRS).$2,407

NHMRC Translational Australian Clinical Toxicology (TACT) Program, Training and Travel Support Scheme  for attendance and  presentation at the 15th International Scientific Conference of the Asia Pacific Medical Association of Medical Toxicology (APAMT) 2016, Singapore 17‐20 November 2016.

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Scheme Program Grant
Role Lead
Funding Start 2016
Funding Finish 2016
GNo
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON N

20151 grants / $3,000

Faculty of Health and Medicine Pilot Grant $3,000

2015 Faculty Pilot Grant for Project: Early snake antivenom administration (ESAA) Study.

Funding body: The University of Newcastle

Funding body The University of Newcastle
Scheme Faculty of Health and Medicine Pilot Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo
Type Of Funding Internal
Category INTE
UON N

20141 grants / $155,747

Combined Treatment for Chronic Cough$155,747

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Nicole Ryan
Scheme Early Career Fellowships
Role Lead
Funding Start 2014
Funding Finish 2017
GNo G1300679
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

20132 grants / $29,810

Pregabalin and Speech Pathology Treatment for Refractory Chronic Cough with Laryngeal Hypersensitivity $23,810

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Nicole Ryan, Doctor Anne Vertigan, Doctor Michael Hayes, Ms Sarah Bone
Scheme Research Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300784
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

HMRI Early Career Travel Award 2012$6,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Nicole Ryan
Scheme Research Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300514
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20121 grants / $4,000

PULSE Education Prize$4,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Nicole Ryan
Scheme PULSE Education Prize
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200455
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

20091 grants / $20,000

HMRI RHD Support Grant$20,000

RHD Support Grant from the Hunter Medical Research Institute [the Greaves family] for PhD candidacy.

Funding body: Hunter Medical Research Institute (HMRI)

Funding body Hunter Medical Research Institute (HMRI)
Project Team

Nicole M Ryan, Peter G Gibson

Scheme Research Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON N

20071 grants / $19,518

Mrs Nicole M Ryan$19,518

Funding body: CCRE in Respiratory and Sleep Medicine

Funding body CCRE in Respiratory and Sleep Medicine
Project Team

Prof Peter G Gibson

Scheme Postgraduate Research Scholarship
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo
Type Of Funding Internal
Category INTE
UON N
Edit

Research Supervision

Number of supervisions

Completed0
Current2

Total current UON EFTSL

PhD0.35

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2015 PhD Snake Envenoming in Australia and Beyond: Investigating Myotoxicity and the Early use of Antivenom PhD (Clinical Pharm), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2015 PhD Antidotes and Treatments in Overdose PhD (Clinical Pharm), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
Edit

Research Projects

ATOM Studies: Pregabalin, Gabapentin Toxicity Project 2015 -

The aim of this project is to investigate the toxic effects and pharmacokinetics of pregabalin and gabapentin in overdose.


Investigating the QT Interval in a Normal Population 2015 -

  The objectives of this study are to:

  1. Investigate the QT interval in a normal population including individual QT variability;
  2. Investigate the relationship between QT and heart rate (RR interval) for individuals in a normal population;
  3. Investigate other factors that many influence the length of the QT interval – age, sex, diurnal variation
  4. Investigate QT hysteresis in a normal population.  Our hypothesis is that about 1 to 3% of the normal population will have an abnormal QT based on the QT nomogram. Little information is known about QT hysteresis in the normal population but previous studies suggest it is on average about 2 minutes.


A randomised controlled trial of early antivenom for red-bellied black snake envenoming 2014 -

The purpose of this project is to investigate the effectiveness and safety of early antivenom administration for the treatment of red-bellied black snake bites/envenoming. Red-bellied black snakebites are the most common in Eastern Australia and are not routinely treated with antivenom because they appear to cause minor effects and there is concern about the risk of allergic reactions to antivenom. However, recent work by the ASP investigators suggests that the early use of antivenom will reduce the chance of people developing muscle damage. This study is a randomised controlled trial of one vial of tiger snake antivenom compared to standard care (placebo) and this will provide good evidence for or against the early administration of antivenom for muscle damage. The study will also investigate whether antivenom neutralises other effects of RBBS envenoming and determine the frequency of allergic reactions, including anaphylaxis, after antivenom use.


Randomised controlled trial of early antivenom administration in Australian snakebite 2015 -

Current standard practice for any snake bite requires laboratory testing to determine if a patient has been envenomed, and coagulation studies are the most important tests. The administration of antivenom is then based on the presence of clinical effects of envenoming and abnormal laboratory investigations. Many of these envenoming effects are irreversible, so once they develop they are unlikely to be reversed by antivenom. This means that, antivenom needs to be given prior to the development of irreversible envenoming syndromes. The aim of this project will be to administer antivenom early – as soon as the patient presents to hospital ‐ without first waiting for laboratory tests or the development of clinical signs of envenoming (except non‐specific symptoms), and/or retrieval to a major hospital for laboratory testing. The objective is to determine if the administration of early antivenom will prevent envenoming effects and therefore significant morbidity or death.


Edit

Dr Nicole Ryan

Position

Postdoctoral Research Fellow
Clinical Toxicology & Pharmacology
School of Medicine and Public Health
Faculty of Health and Medicine

Focus area

Public Health

Contact Details

Email nicole.ryan@newcastle.edu.au
Phone (02) 4921 1312
Fax (02) 4921 1870
Link Twitter

Office

Room 5.46A, Level 5 New Med Building
Building Calvary Mater Newcastle
Location Calvary Mater Newcastle Hospital

,
Edit