Dr Mohit Sharma

Dr Mohit Sharma

Postdoctoral Fellow

Office - DVC (Research and Innovation)

Career Summary

Biography

Background

Dr Mohit Sharma completed his PhD (Biomedical Sciences) at Ulster University, Northern Ireland, UK, where he investigated the neuroprotective properties of incretin gut peptide hormones, glucagon-like-peptide 1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP). He found the involvement of MAPK ERK signalling pathways as an underlying mechanism of the neuroprotective and anti-apoptotic role of incretins in human neuroblastoma cells against methyl glyoxal stress. A part of his PhD thesis work including dose-dependent cytotoxicity and cell viability studies contributed towards a patent for the use of incretins in the treatment of neurodegenerative diseases. To further explore the bench to bedside potential of these gut peptides, Mohit decided to undertake post-doctoral research in the field of translational medicine.

In July 2014, Mohit relocated to Lancaster University, UK, to work on a Cure Parkinson’s Trust funded project investigating the neuroprotective effects of a novel incretin dual-agonist in a 6-hydroxy dopamine unilateral-lesioned rat model of Parkinson’s disorder. He found that this novel incretin analogue holds promise as an effective treatment for Parkinson’s disorder and demonstrated an involvement of pAkt/CREB cell signalling along with a significant improvement in the motor impairments and preventing loss of dopaminergic neurons in the substantia nigra.

Following his relocation to Australia with family in 2017 and after a period of parental leave, Dr Sharma was recruited as a post-doctoral research fellow in the Laboratory of NeuroImmunology at the University of Newcastle in 2019 recognising his expertise in generating animal models of neurodegenerative disorders, drug development both in-vivo and in-vitro, animal behavioural research and proteomics. Here, he continues to build on the concepts of Perinatal programming and study neonatal inflammation in the developing brain and its systemic links in a rat model to decipher the role of kynurenine pathway in anxiety during adulthood. 

Current research interests

Understanding the role of kynurenine pathway in the neonatal inflammation-induced anxiety like behaviour in adulthood.

Dr Sharma is interested in investigating the underlying mechanisms involved in the early life inflammation-induced anxiety. The developing brain is highly susceptible to environmental variations because of the developmental plasticity of neuronal networks during childhood. To understand the role of kynurenine pathway, Mohit will utilise a lipopolysaccharide rat model that displays anxiety-like behaviour in adulthood. He is interested in mapping the kynurenine metabolites and performing gene expression studies and cytokine profiling across the key developmental stages of life in response to a neonatal immune challenge.

Collaborators: Dr Adam Walker (Neuroscience Research Australia, UNSW), Dr Edwin Lim (Macquarie University, NSW)


Qualifications

  • PHD IN Bio Medical Sciences, University of Ulster
  • Masters in Biotechnology, University of Ulster

Keywords

  • Animal behaviour
  • Anxiety
  • Cell signalling
  • Cytokine profiling
  • Early life Inflammation
  • Immunohistochemistry
  • Kynurenine
  • Lipopolysaccharide
  • Microglial activation
  • Neuroinflammation
  • Rodent models of disease

Languages

  • English (Fluent)

Fields of Research

Code Description Percentage
170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) 30
110999 Neurosciences not elsewhere classified 50
060105 Cell Neurochemistry 20

Professional Experience

UON Appointment

Title Organisation / Department
Postdoctoral Fellow University of Newcastle
Office - DVC (Research and Innovation)
Australia

Professional appointment

Dates Title Organisation / Department
15/7/2014 - 14/7/2016 Post doctoral Research Associate Lancaster University
Biomedical and Life Sciences
United Kingdom
1/1/2011 - 31/12/2012 Tutor The University of Ulster
Biomedical Sciences
United Kingdom
1/7/2009 - 30/6/2010 Research Scholar The University of Texas Health Science Center at San Antonio
United States

Awards

Award

Year Award
2012 Alzheimer's Research UK Travel Award
Alzheimer's Research UK
2011 Alzheimer's Research UK Travel Award
Alzheimer's Research UK

Scholarship

Year Award
2010 Vice Chancellor's Research Scholarship
The University of Ulster
2005 Commonwealth Master's Scholarship
The University of Ulster
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (6 outputs)

Year Citation Altmetrics Link
2017 Jalewa J, Sharma MK, Gengler S, Holscher C, 'A novel GLP-1/GIP dual receptor agonist protects from 6-OHDA lesion in a rat model of Parkinson's disease', NEUROPHARMACOLOGY, 117 238-248 (2017)
DOI 10.1016/j.neuropharm.2017.02.013
Citations Scopus - 29Web of Science - 29
2016 Jalewa J, Sharma MK, Holscher C, 'Novel incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cells', JOURNAL OF NEUROCHEMISTRY, 139 55-67 (2016)
DOI 10.1111/jnc.13736
Citations Scopus - 36Web of Science - 35
2015 Liu W, Jalewa J, Sharma M, Li G, Li L, Hoelscher C, 'NEUROPROTECTIVE EFFECTS OF LIXISENATIDE AND LIRAGLUTIDE IN THE 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MOUSE MODEL OF PARKINSON'S DISEASE', NEUROSCIENCE, 303 42-50 (2015)
DOI 10.1016/j.neuroscience.2015.06.054
Citations Scopus - 76Web of Science - 71
2014 Sharma MK, Jalewa J, Hoelscher C, 'Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress', JOURNAL OF NEUROCHEMISTRY, 128 459-471 (2014)
DOI 10.1111/jnc.12469
Citations Scopus - 85Web of Science - 85
2012 Hart MJ, Glicksman M, Liu M, Sharma MK, Cuny G, Galvan V, 'Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein', Analytical Biochemistry, 421 467-476 (2012)
DOI 10.1016/j.ab.2011.11.020
2007 Graham R, Sharma MK, Ternan NG, Weatherly DB, Tarleton RL, McMullan G, 'A semi-quantitative GeLC-MS analysis of temporal proteome expression in the emerging nosocomial pathogen Ochrobactrum anthropi', Genome Biology, 8 R110-R110 (2007)
DOI 10.1186/gb-2007-8-6-r110
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Research Collaborations

The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.

Country Count of Publications
United Kingdom 4
China 1
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Dr Mohit Sharma

Position

Postdoctoral Fellow
Office - DVC (Research and Innovation)
Research and Innovation Division

Contact Details

Email mohit.sharma@newcastle.edu.au
Phone (02) 4055 3340

Office

Room SR-265
Building Behavioural Sciences Building
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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