2023 |
Lucock MD, 'Vitomics: A novel paradigm for examining the role of vitamins in human biology.', Bioessays, 45 e2300127 (2023) [C1]
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Nova |
2023 |
Lucock MD, 'The evolution of human skin pigmentation: A changing medley of vitamins, genetic variability, and
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Nova |
2023 |
Ferraris C, Scarlett CJ, Veysey M, Lucock M, Bucher T, Beckett EL, 'Salt-Taste Polymorphism TRPV1-rs8065080 Is Associated with Increased Likelihood of Depression in an Elderly Cohort.', Lifestyle Genom, 16 224-236 (2023) [C1]
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Nova |
2022 |
Lucock M, 'Vitamin-related phenotypic adaptation to exposomal factors: The folate-vitamin D-exposome triad', Molecular Aspects of Medicine, 87 (2022) [C1]
The biological role of two key vitamins, folic acid and vitamin D is so fundamental to life processes, it follows that their UV sensitivity, dietary abundance (both key exposomal ... [more]
The biological role of two key vitamins, folic acid and vitamin D is so fundamental to life processes, it follows that their UV sensitivity, dietary abundance (both key exposomal factors) and variability in dependent genes will modify their functional efficacy, particularly in the context of maintaining the integrity and function of genome and epigenome. This article therefore examines folate and vitamin D-related phenotypic adaptation to environmental factors which vary across the human life cycle as well as over an evolutionary time-scale. Molecular mechanisms, key nutrigenomic factors, phenotypic maladaptation and evolutionary models are discussed.
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Nova |
2022 |
Lucock MD, 'A Brief Introduction to Darwinian Medicine', Exploratory Research and Hypothesis in Medicine, 7 108-124 (2022)
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2022 |
Lucock MD, Jones PR, Veysey M, Thota R, Garg M, Furst J, et al., 'Biophysical evidence to support and extend the vitamin D-folate hypothesis as a paradigm for the evolution of human skin pigmentation', American Journal of Human Biology, 34 (2022) [C1]
Objective: To test the ¿vitamin D-folate hypothesis for the evolution of human skin pigmentation.¿. Methods: Total ozone mapping spectrometer (TOMS) satellite data were used to ex... [more]
Objective: To test the ¿vitamin D-folate hypothesis for the evolution of human skin pigmentation.¿. Methods: Total ozone mapping spectrometer (TOMS) satellite data were used to examine surface UV-irradiance in a large (n¿= 649) Australian cross-sectional study population. Genetic analysis was used to score vitamin D- and folate-related gene polymorphisms (n¿= 22), along with two pigmentation gene variants (IRF4-rs12203592/HERC2-rs12913832). Red cell folate and vitamin D3 were measured by immunoassay and HPLC, respectively. Results: Ultraviolet radiation (UVR) and pigmentation genes interact to modify blood vitamin levels; Light skin IRF4-TT genotype has greatest folate loss while light skin HERC2-GG genotype has greatest vitamin D3 synthesis (reflected in both TOMS and seasonal data). UV-wavelength exhibits a dose¿response relationship in folate loss within light skin IRF4-TT genotype (305 > 310 > 324 > 380 nm). Significant vitamin D3 photosynthesis only occurs within light skin HERC2-GG genotype, and is maximal at 305 nm. Three dietary antioxidants (vitamins C, E, and ß-carotene) interact with UVR and pigmentation genes preventing oxidative loss of labile reduced folate vitamers, with greatest benefit in light skin IRF4-TT subjects. The putative photosensitiser, riboflavin, did not sensitize red cell folate to UVR and actually afforded protection. Four genes (5xSNPs) influenced blood vitamin levels when stratified by pigmentation genotype; MTHFR-rs1801133/rs1801131, TS-rs34489327, CYP24A-rs17216707, and VDR-ApaI-rs7975232. Lightest IRF4-TT/darkest HERC2-AA genotype combination (greatest folate loss/lowest vitamin D3 synthesis) has 0% occurrence. The opposing, commonest (39%) compound genotype (darkest IRF4-CC/lightest HERC2-GG) permits least folate loss and greatest synthesis of vitamin D3. Conclusion: New biophysical evidence supports the vitamin D-folate hypothesis for evolution of skin pigmentation.
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Nova |
2021 |
Lucock M, 'TheAnthropocene: Exploring its origins, biology, and future', AMERICAN JOURNAL OF HUMAN BIOLOGY, 33 (2021)
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2021 |
Turner A, Veysey M, Keely S, Scarlett CJ, Lucock M, Beckett EL, 'Genetic Variation in the Bitter Receptors Responsible for Epicatechin Detection Are Associated with BMI in an Elderly Cohort', NUTRIENTS, 13 (2021) [C1]
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Nova |
2021 |
Kaur K, Sculley D, Veysey M, Lucock M, Wallace J, Beckett EL, 'Bitter and sweet taste perception: relationships to self-reported oral hygiene habits and oral health status in a survey of Australian adults', BMC ORAL HEALTH, 21 (2021) [C1]
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2021 |
Ferraris C, Turner A, Scarlett C, Veysey M, Lucock M, Bucher T, Beckett EL, 'Association between Sour Taste SNP KCNJ2-rs236514, Diet Quality and Mild Cognitive Impairment in an Elderly Cohort', Nutrients, 13 719-719 [C1]
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Nova |
2021 |
Ferraris C, Turner A, Scarlett CJ, Veysey M, Lucock M, Bucher T, Beckett EL, 'Sour Taste SNP KCNJ2-rs236514 and Differences in Nutrient Intakes and Metabolic Health Markers in the Elderly', FRONTIERS IN NUTRITION, 8 (2021) [C1]
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Nova |
2021 |
Lucock M, 'RE: O. Mottl et al., Science, 372, 10.1126/science.abg1685 (2021)', Science, 372 860-860 (2021) |
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2021 |
Kaur K, Turner A, Jones P, Sculley D, Veysey M, Lucock M, et al., 'A Cross-Sectional Study of Bitter-Taste Receptor Genotypes, Oral Health, and Markers of Oral Inflammation', Oral, 1 122-138 (2021) [C1]
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Nova |
2020 |
Lucock MD, 'A Brief Introduction to the Exposome and Human Health', Exploratory Research and Hypothesis in Medicine, 000 1-6 (2020)
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2020 |
Jones P, Lucock M, Chaplin G, Jablonski NG, Veysey M, Scarlett C, Beckett E, 'Distribution of variants in multiple vitamin D-related loci (DHCR7/NADSYN1, GC, CYP2R1, CYP11A1, CYP24A1, VDR, RXRa and RXR ) vary between European, East-Asian and Sub-Saharan African-ancestry populations', Genes and Nutrition, 15 (2020) [C1]
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Nova |
2020 |
Jones P, Lucock M, Scarlett CJ, Veysey M, Beckett E, 'Environmental UVR levels and skin pigmentation gene variants associated with folate and homocysteine levels in an elderly cohort', International Journal of Environmental Research and Public Health, 17 (2020) [C1]
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Nova |
2020 |
Jones P, Lucock M, Martin C, Thota R, Garg M, Yates Z, et al., 'Independent and interactive influences of environmental UVR, vitamin D levels, and folate variant MTHFD1-RS2236225 on homocysteine levels', Nutrients, 12 (2020) [C1]
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Nova |
2020 |
Turner A, Veysey M, Keely S, Scarlett CJ, Lucock M, Beckett EL, 'Intense sweeteners, taste receptors and the gut microbiome: A metabolic health perspective', International Journal of Environmental Research and Public Health, 17 1-18 (2020) [C1]
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Nova |
2020 |
Ferraris C, Turner A, Kaur K, Piper J, Veysey M, Lucock M, Beckett EL, 'Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort', Nutrients, 12 (2020) [C1]
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Nova |
2019 |
Jones P, Lucock M, Scarlett CJ, Veysey M, Beckett EL, 'Folate and Inflammation links between folate and features of inflammatory conditions', Journal of Nutrition and Intermediary Metabolism, 18 (2019) [C1]
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Nova |
2019 |
Kaur K, Sculley D, Wallace J, Turner A, Ferraris C, Veysey M, et al., 'Micronutrients and bioactive compounds in oral inflammatory diseases', Journal of Nutrition and Intermediary Metabolism, 18 (2019) [C1]
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Nova |
2019 |
Turner A, Chijoff E, Veysey M, Keely S, Scarlett CJ, Lucock M, Beckett EL, 'Interactions between taste receptors and the gastrointestinal microbiome in inflammatory bowel disease', Journal of Nutrition and Intermediary Metabolism, 18 (2019) [C1]
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Nova |
2019 |
Lucock M, Thota R, Garg M, Martin C, Jones P, Furst J, et al., 'Early lifecycle UV-exposure calibrates adult vitamin D metabolism: Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes', American Journal of Human Biology, 31 (2019) [C1]
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Nova |
2019 |
D Cunha NM, Georgousopoulou EN, Boyd L, Veysey M, Sturm J, O Brien B, et al., 'Relationship Between B-Vitamin Biomarkers and Dietary Intake with Apolipoprotein E 4 in Alzheimer s Disease', Journal of Nutrition in Gerontology and Geriatrics, 38 173-195 (2019) [C1]
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Nova |
2018 |
Turner A, Veysey M, Keely S, Scarlett C, Lucock M, Beckett EL, 'Interactions between Bitter Taste, Diet and Dysbiosis: Consequences for Appetite and Obesity.', Nutrients, 10 (2018) [C1]
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Nova |
2018 |
Lucock M, Jones P, Martin C, Yates Z, Veysey M, Furst J, Beckett E, 'Photobiology of vitamins', Nutrition reviews, 76 512-525 (2018) [C1]
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Nova |
2018 |
Jones P, Lucock M, Veysey M, Jablonski N, Chaplin G, Beckett E, 'Frequency of folate-related polymorphisms varies by skin pigmentation', AMERICAN JOURNAL OF HUMAN BIOLOGY, 30 (2018) [C1]
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Nova |
2018 |
Jones P, Lucock M, Veysey M, Beckett E, 'Reply: "Comment on: The Vitamin D-Folate Hypothesis as an Evolutionary Model for Skin Pigmentation: An Update and Integration of Current Ideas, Nutrients 2018, 10, 554"', NUTRIENTS, 10 (2018)
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2018 |
Lucock M, Thota R, Garg M, Martin C, Jones P, Furst J, et al., 'Vitamin D and folate: A reciprocal environmental association based on seasonality and genetic disposition', AMERICAN JOURNAL OF HUMAN BIOLOGY, 30 (2018) [C1]
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Nova |
2018 |
Jones P, Lucock M, Veysey M, Beckett E, 'The vitamin D folate hypothesis as an evolutionary model for skin pigmentation: An update and integration of current ideas', Nutrients, 10 1-13 (2018) [C1]
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Nova |
2017 |
Martin C, Yates Z, Veysey M, King K, Niblett S, Lucock M, 'Vitamin D-related Nutrigenetics and Cognitive Decline in an Elderly Population', Exploratory Research and Hypothesis in Medicine, 2 1-8 (2017)
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2017 |
Suter S, Lucock M, 'Xenohormesis: Applying Evolutionary Principles to Contemporary Health Issues', Exploratory Research and Hypothesis in Medicine, 2 1-7 (2017)
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2017 |
Lucock M, 'Editorial: Novel and Contemporary Perspectives in Medical Nutrition', Exploratory Research and Hypothesis in Medicine, 2 77-78 (2017)
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2017 |
Beckett E, Jones P, Veysey M, Lucock M, 'Nutrigenetics Personalized Nutrition in the Genetic Age', Exploratory Research and Hypothesis in Medicine, (2017)
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2017 |
Thota RN, Abbott KA, Ferguson JJA, Veysey M, Lucock M, Niblett S, et al., 'InsuTAG: A novel physiologically relevant predictor for insulin resistance and metabolic syndrome.', Scientific reports, 7 15204 (2017) [C1]
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Nova |
2017 |
Beckett EL, Veysey M, Lucock MD, 'Folate and microRNA: Bidirectional interactions', Clinica Chimica Acta, 474 60-66 (2017) [C1]
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Nova |
2017 |
Lucock M, Jones P, Veysey M, Beckett E, 'B vitamins and pollution, an interesting, emerging, yet incomplete picture of folate and the exposome', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114 E3878-E3879 (2017)
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2017 |
Lucock M, Beckett E, Martin C, Jones P, Furst J, Yates Z, et al., 'UV-associated decline in systemic folate: implications for human nutrigenetics, health, and evolutionary processes', AMERICAN JOURNAL OF HUMAN BIOLOGY, 29 (2017) [C1]
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Nova |
2017 |
Beckett EL, Jones P, Veysey M, Duesing K, Martin C, Furst J, et al., 'VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences', AMERICAN JOURNAL OF HUMAN BIOLOGY, 29 (2017) [C1]
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Nova |
2017 |
Beckett EL, Porter T, Boyd L, King K, Niblett S, Yates Z, et al., 'A TAS2R38 genotype dependent response to mandatory folic acid fortification: A comparison of two elderly cohorts.', Journal of Nutrition & Intermediary Metabolism, 8 84-84 (2017) |
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2017 |
Beckett EL, Martin C, Boyd L, Porter T, King K, Niblett S, et al., 'Reduced plasma homocysteine levels in elderly Australians following mandatory folic acid fortification A comparison of two cross-sectional cohorts', Journal of Nutrition and Intermediary Metabolism, 8 14-20 (2017) [C1]
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Nova |
2017 |
Beckett EL, Duesing K, Boyd L, Yates Z, Veysey M, Lucock M, 'A potential sex dimorphism in the relationship between bitter taste and alcohol consumption', FOOD & FUNCTION, 8 1116-1123 (2017) [C1]
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Nova |
2017 |
Sculley DV, Lucock M, 'Maternal Undernutrition and Type 2 Diabetes in Australian Aboriginal and Torres Strait Islander People: History and Future Direction', Exploratory Research and Hypothesis in Medicine, 2 117-121 (2017)
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2016 |
Yates Z, Lucock M, Veysey M, Choi JH, 'Elevated folic acid results in contrasting cancer cell line growth with implications for mandatory folic acid fortification', Journal of Nutrition and Health, 49 72-79 (2016) [C1]
Purpose: The initiation of mandatory folic acid fortification using pteroylmonoglutamic acid (PteGlu) has reduced the rate of congenital malformations. However, it also appears to... [more]
Purpose: The initiation of mandatory folic acid fortification using pteroylmonoglutamic acid (PteGlu) has reduced the rate of congenital malformations. However, it also appears to be responsible for several adverse effects, including increased cancer incidence. This may be related to physicho-chemical characteristics of PteGlu. This study examines the potential effect of high concentrations of PteGlu on a population subjected to mandatory folic acid fortification using an in vitro model. Methods: Caco-2 (colorectal cancer) and MCF7 (breast cancer) cell lines were cultured at 6 different PteGlu concentrations (0, 0.1, 1, 50, 250, and 500µg/ml) for 6 days. Cell growth was determined using thiazolyl blue tetrazolium bromide assay. The genotype of dihydrofolate reductase 19bp deletion/insertion (DHFR 19-del) was also scored in cell lines using a restriction fragment length polymorphism technique to examine whether genetic variations may factor in cell proliferation. Results: PteGlu exhibited differential growth promoting properties between cell lines. Caco-2 cells did not show a significant growth difference at low concentrations compared to control, however, at higher concentrations, the growth showed a contrasting trend in the early experimental period, while MCF7 showed enhanced cell growth at all concentrations. The DHFR 19-del genotype differed in the two cell lines. Conclusions: Altered response to PteGlu by Caco-2 and MCF7 may reflect a tissue specific disease aetiology or genotype specific differential enzyme activity, for example by DHFR, to critical levels of PteGlu. As folic acid fortification is a blanket intervention, and DHFR and other enzyme activities vary between individuals, PteGlu intake may have an as yet undefined effect on health. These findings may be relevant when considering mandatory folic acid fortification for disease prevention.
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Nova |
2016 |
Jones P, Beckett EL, Yates Z, Veysey M, Lucock M, 'Converging Evolutionary, Environmental and Clinical Ideas on
Folate Metabolism', Exploratory Research and Hypothesis in Medicine, 1 34-41 (2016) [C1]
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Nova |
2016 |
Beckett EL, Le Gras K, Martin C, Boyd L, Ng X, Duesing K, et al., 'Vitamin D receptor polymorphisms relate to risk of adenomatous polyps in a sex-specific manner', Nutrition and Cancer, 68 193-200 (2016) [C1]
Vitamin D receptor (VDR) gene polymorphisms may influence risk for adenomatous polyps (AP), a benign precursor to colon cancer, via modulation of vitamin D sensitive pathways, inc... [more]
Vitamin D receptor (VDR) gene polymorphisms may influence risk for adenomatous polyps (AP), a benign precursor to colon cancer, via modulation of vitamin D sensitive pathways, including cell proliferation and differentiation. However, results have been mixed and any association remains contentious. Failure to clinically exclude the presence of (AP in control cohorts may contribute to the lack of consensus. Therefore, we assessed the role of the FokI, BsmI, ApaI, and TaqI VDR polymorphisms in modifying risk for AP, adjusting for a range of dietary and lifestyle variables. Blood was collected from colonoscopy patients (n = 258) and VDR polymorphisms assessed by restriction fragment length polymorphism. Dietary habits were estimated from food frequency questionnaires. Odds ratios for AP were calculated by genotype, stratified by sex, and adjusted for age, lifestyle, and dietary factors. FokI was associated with modified risk for AP in males, whereas the BsmI/ApaI/TaqI haplotype was associated with modified risk in females. No interaction was found between VDR variants and vitamin D intake. This study offers novel insight into the potential for VDR genetics to contribute to risk for AP and is the first to demonstrate a sex-specific relationship between these polymorphisms and risk for AP.
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Nova |
2016 |
Abbott KA, Veysey M, Lucock M, Niblett S, King K, Burrows T, Garg ML, 'Sex-dependent association between erythrocyte n-3 PUFA and type 2 diabetes in older overweight people.', Br J Nutr, 115 1379-1386 (2016) [C1]
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Nova |
2016 |
Beckett EL, Duesing K, Martin C, Jones P, Furst J, King K, et al., 'Relationship between methylation status of Vitamin D-related genes, Vitamin D levels, and methyl-donor biochemistry', Journal of Nutrition and Intermediary Metabolism, 6 8-15 (2016) [C1]
Vitamin D is known for its role in the regulation of gene expression via the Vitamin D receptor, a nuclear transcription factor. More recently, a role for Vitamin D in regulating ... [more]
Vitamin D is known for its role in the regulation of gene expression via the Vitamin D receptor, a nuclear transcription factor. More recently, a role for Vitamin D in regulating DNA methylation has been identified as an additional mechanism of modulation of gene expression. How methylation status influences Vitamin D metabolism and response pathways is not yet clear. Therefore, we aimed to assess the relationship between plasma 25-hydroxycholecalciferol (25(OH)D) and the methylation status of Vitamin D metabolism enzyme genes (CYP2R1, CYP27B1 and CYP24A1) and the Vitamin D receptor gene (VDR). This analysis was conducted in the context of dietary Vitamin D, and background methyl donor related biochemistry, with adjustment for several dietary and lifestyle variables. Percentage methylation at CpG sites was assessed in peripheral blood cells using methylation sensitive and dependent enzymes and qPCR. Standard analytical techniques were used to determine plasma 25(OH)D and homocysteine, and serum folate and B12, with the relationship to methylation status assessed using multi-variable regression analysis. CYP2R1 and VDR methylation were found to be independent predictors of plasma 25(OH)D, when adjusted for Vitamin D intake and other lifestyle variables. CYP24A1 was related to plasma 25(OH)D directly, but not in the context of Vitamin D intake. Methyl-group donor biochemistry was associated with the methylation status of some genes, but did not alter the relationship between methylation and plasma 25(OH)D. Modulation of methylation status of CYP2R1, CYP24A1 and VDR in response to plasma 25(OH)D may be part of feedback loops involved in maintaining Vitamin D homeostasis, and may explain a portion of the variance in plasma 25(OH)D levels in response to intake and sun exposure. Methyl-group donor biochemistry, while a potential independent modulator, did not alter this effect.
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Nova |
2016 |
Mingay E, Veysey M, Lucock M, Niblett S, King K, Patterson A, Garg M, 'Sex-dependent association between omega-3 index and body weight status in older Australians', Journal of Nutrition and Intermediary Metabolism, 5 70-77 (2016) [C1]
Background/objectives Restricting energy intake for weight management in older adults has potential to adversely affect nutritional status and result in impairment of an already c... [more]
Background/objectives Restricting energy intake for weight management in older adults has potential to adversely affect nutritional status and result in impairment of an already compromised immune system. Investigation of alternative strategies to combat adiposity and sustain lean muscle mass in older adults are warranted to minimise the risk of developing chronic diseases. Long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may play an important role through their impact on increased fat oxidation and reduced inflammation. This study aimed to examine the association between erythrocyte membrane LCn-3PUFA and anthropometric measures in an older population. Subjects/methods A cross-sectional sample of older adults (n¿=¿620; age 65¿95 years; 56.3% females) from the Retirement Health and Lifestyle Study (RHLS) was analysed. Anthropometric measurements, including height, weight, body mass index (BMI), waist (WC) and hip circumference (HC) were taken. The fatty acid composition of erythrocyte membranes was analysed via gas chromatography (GC) to determine the omega-3 index (%EPA plus %DHA). Results An inverse association was detected between the omega-3 index and anthropometric measures, BMI (r¿=¿-0.076, p=0.06), WC (r¿=¿-0.118, p¿<¿0.01) and waist-to-hip ratio (WHR; r¿=¿-0.149, p¿<¿0.001). Stratification of data by sex (females, n¿=¿349; males, n¿=¿271) indicated that these associations were sex-specific. Females displayed an inverse association between the omega-3 index and BMI (r¿=¿-0.146, p¿<¿0.01) and WC (r¿=¿-0.125, p¿<¿0.05). In contrast, no significant association between the omega-3 index and anthropometric measures was detected in males. After correcting for the potentially confounding effects of age, household income, fish oil supplement status, daily dietary energy intake and total physical activity times, the omega-3 index was inversely associated with BMI and WC in females but not males. Conclusions Omega-3 status was associated with weight status, particularly in older women but not in men. These results suggest the need for sex-based intervention trials to examine the role of dietary intake and/or supplementation of LCn-3PUFA in weight management of older adults.
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Nova |
2016 |
Rose M, Veysey M, Lucock M, Niblett S, King K, Baines S, Garg ML, 'Association between erythrocyte omega-3 polyunsaturated fatty acid levels and fatty liver index in older people is sex dependent', Journal of Nutrition and Intermediary Metabolism, 5 78-85 (2016) [C1]
Background/Objectives Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in older people but currently no specific drugs are available for its treatment. Omega-3 polyun... [more]
Background/Objectives Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in older people but currently no specific drugs are available for its treatment. Omega-3 polyunsaturated fatty acids (n-3PUFA), known for their lipid-lowering, anti-inflammatory and anti-hypertensive properties, may have therapeutic potential for the management of NAFLD. The aim of this study was to determine whether n-3PUFA levels are associated with the prevalence of NAFLD in older adults. Methods A cross-sectional sample of older adults aged 65¿95 years (n¿=¿620) from the Retirement Health and Lifestyle Study (RHLS) was analysed. Fatty Liver Index (FLI) scores, used as an indicator of NAFLD risk, were calculated using a validated algorithm that incorporates body mass index, waist circumference, plasma triglycerides and ¿-glutamyl transferase. Omega-3 index scores (O3I, %eicosapentaenoic acid plus %docosahexaenoic acid) were determined by analysing the fatty acid composition of erythrocyte membranes by gas chromatography. Results Following application of exclusion criteria, 475 participants were included in the analysis (age 77.9¿±¿7.0 years; 60.4% females). Of these, 216 participants had FLI scores (=60) suggestive of NAFLD (age 77.0¿±¿6.6 years; 49.1% females). O3I was significantly lower in participants with NAFLD compared to those without NAFLD (p¿<¿0.01). A significant inverse relationship was found between O3I and FLI (r¿=¿-0.165; p¿<¿0.001). This relationship was gender specific with women, but not men, showing a significant association (r¿=¿-0.206; p¿<¿0.001). Conclusions The current study demonstrated a sex-dependent inverse relationship between erythrocyte n-3PUFA concentrations and NAFLD in older adults. The finding supports the proposal for sex-stratified n-3PUFA intervention trials in this high-risk age group.
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Nova |
2016 |
Olliver M, Veysey M, Lucock M, Niblett S, King K, MacDonald-Wicks L, Garg ML, 'Erythrocyte omega-3 polyunsaturated fatty acid levels are associated with biomarkers of inflammation in older Australians', Journal of Nutrition and Intermediary Metabolism, 5 61-69 (2016) [C1]
Background Elevated levels of pro-inflammatory mediators heighten the risk of developing or aggravating a spectrum of chronic diseases and are a strong predictor of mortality in e... [more]
Background Elevated levels of pro-inflammatory mediators heighten the risk of developing or aggravating a spectrum of chronic diseases and are a strong predictor of mortality in elderly cohorts. Omega-3 polyunsaturated fatty acids (n-3PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are known to possess anti-inflammatory properties. However, the relationship between erythrocyte membrane n-3PUFA and inflammation biomarkers has not been well established. Objective This study aimed to determine if n-3PUFA status, together with the omega-3 index (O3I, erythrocyte membrane % EPA plus DHA), is associated with pro-inflammatory mediators in older Australians. Methods The study was a cross-sectional analysis of randomly selected older men and women aged =65 years (n¿=¿620) recruited from the Central Coast of NSW, Australia. Fasted blood samples were analysed for C-reactive protein (CRP), fibrinogen and full blood count using standardised laboratory methods. The fatty acid composition of erythrocyte membranes was analysed via gas chromatography to determine n-3PUFA levels. The relationships between n-3PUFA and inflammatory mediators were evaluated in multivariate regression models after adjusting for known inflammatory confounders. Results After excluding participants who had an inflammatory disease, CRP levels >10¿mg/L, or who were taking anti-inflammatory medications or n-3PUFA supplements, 126 participants (age 77.6¿±¿7.3 years; females, 46%) were included in the analysis. After multivariate adjustments, O3I was inversely associated with CRP (ß¿=¿-0.209, p¿<¿0.05) and monocyte cell counts (ß¿=¿-0.205, p¿<¿0.05), and total n-3PUFA was inversely related to WBC (ß¿=¿-0.238, p¿<¿0.05), neutrophils (ß¿=¿-0.212, p¿<¿0.05) and monocytes (ß¿=¿-0.246, p¿<¿0.05). However no association between fibrinogen and O3I or total n-3PUFA was detected. Conclusions This study demonstrated a negative association between O3I and biomarkers of inflammation in an older population. The findings support a potential role for n-3PUFA supplementation in the management of inflammatory diseases.
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Nova |
2016 |
Ferguson JJA, Veysey M, Lucock M, Niblett S, King K, MacDonald-Wicks L, Garg ML, 'Association between omega-3 index and blood lipids in older Australians', Journal of Nutritional Biochemistry, 27 233-240 (2016) [C1]
Management of hyperlipidaemia remains a cornerstone therapy for the prevention of cardiovascular disease (CVD). Dietary supplementation with n-3 polyunsaturated fatty acid (PUFA) ... [more]
Management of hyperlipidaemia remains a cornerstone therapy for the prevention of cardiovascular disease (CVD). Dietary supplementation with n-3 polyunsaturated fatty acid (PUFA) has been shown to modulate blood lipid profiles and reduce the risk of developing CVD. However, studies relating objective measures of long-term dietary n-3 PUFA intake and circulating lipid levels in older adults are limited. Thus, we aimed to determine whether there is an association between erythrocyte n-3 PUFA status (omega-3 index, O3I) and blood lipid profiles in older adults. A sample of adults aged 65-95 years who participated in the Retirement Health and Lifestyle Study was evaluated. Outcome measures included O3I (% eicosapentaenoic acid+% docosahexaenoic acid) and fasting blood lipid profiles [total cholesterol (TC), low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol and triglyceride (TG)]. Two hundred and seventy-six subjects were included in the analyses. The mean±SD age was 77.6±7.4 years, and 40.9% were males. O3I was significantly higher in females compared to males. O3I was inversely associated with plasma TG (P<.001) and TC/HDL-cholesterol ratio (P<.05), and positively associated with HDL-cholesterol (P<.05), in all subjects. Associations between O3I and TG were evident in both females (r=-0.250, P<.01) and males (r=-0.225, P<.05). In females only, the odds of being hypertriglyceridaemic were highest in those with lowest O3I (P=006). Trends for hypercholesterolaemia and elevated LDL risk were converse between males and females. Long-term n-3 PUFA status is associated with blood lipid profiles in older Australians. Our findings support the development and implementation of age-specific dietary strategies to reduce the risk of CVD via improving the O3I.
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Nova |
2015 |
Lucock M, Jones P, Martin C, Beckett E, Yates Z, Furst J, Veysey M, 'Vitamin D: Beyond Metabolism', Journal of Evidence-Based Complementary and Alternative Medicine, 20 310-322 (2015) [C1]
Interest in vitamin D and the VDR gene is increasing as putative roles in human health and evolutionary processes are explored. This review looks beyond the classic biochemistry t... [more]
Interest in vitamin D and the VDR gene is increasing as putative roles in human health and evolutionary processes are explored. This review looks beyond the classic biochemistry that links vitamin D to calcium homeostasis; it explores how vitamin D interacts with light in a broader perspective than simple skin photosynthesis. It examines how the vitamin influences circadian rhythm, and how it may have helped drive the evolution of skin pigmentation. To this end, the nutrient¿nutrient relationship with folate is also explored. The VDR gene is additionally examined as a factor in the evolutionary selection of skin depigmentation at higher latitudes to allow vitamin D synthesis. Evidence is given to show that VDR polymorphisms exhibit a latitudinal gradient in allele prevalence consistent with such a paradigm. Overall, the review examines new evo-devo ideas that link light-sensitive vitamins to human health/phenotype, both within and across the lifecycle.
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Nova |
2015 |
Lucock M, Yates Z, Martin C, Choi JH, Beckett E, Boyd L, et al., 'Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence', BBA Clinical, 3 107-112 (2015) [C1]
Purpose: The aim of this study is to explore whether a methylation diet influences risk for adenomatous polyps (AP) either independently, or interactively with one-carbon metaboli... [more]
Purpose: The aim of this study is to explore whether a methylation diet influences risk for adenomatous polyps (AP) either independently, or interactively with one-carbon metabolism-dependent gene variants, and whether such a diet modifies blood homocysteine, a biochemical phenotype closely related to the phenomenon of methylation. Methods: 249 subjects were examined using selective fluorescence, PCR and food frequency questionnaire to determine homocysteine, nine methylation-related gene polymorphisms, dietary methionine, 5-methyltetrahydrofolate, vitamins B6 and B12. Results: 1). Both dietary methionine and 5-methyltetrahydrofolate intake are significantly associated with plasma homocysteine. 2). Dietary methionine is related to AP risk in 2R3R-TS wildtype subjects, while dietary B12 is similarly related to this phenotype in individuals heterozygous for C1420T-SHMT, A2756G-MS and 844ins68-CBS, and in those recessive for 2R3R-TS. 3). Dietary methionine has a marginal influence on plasma homocysteine level in C1420T-SHMT heterozygotes, while B6 exhibits the same effect on homocysteine in C776G-TCN2 homozygote recessive subjects. Natural 5-methyltetrahydrofolate intake is interesting: Wildtype A1298C-MTHFR, heterozygote C677T-MTHFR, wildtype A2756G-MS and recessive A66G-MSR individuals all show a significant reciprocal association with homocysteine. 4). Stepwise regression of all genotypes to predict risk for AP indicated A2756G-MS and A66G-MSR to be most relevant (p= 0.0176 and 0.0408 respectively). Results were corrected for age and gender. Conclusion: A methylation diet influences methyl group synthesis in the regulation of blood homocysteine level, and is modulated by genetic interactions. Methylation-related nutrients also interact with key genes to modify risk of AP, a precursor of colorectal cancer. Independent of diet, two methylation-related genes (A2756G-MS and A66G-MSR) were directly associated with AP occurrence.
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Nova |
2015 |
Choi J-H, Yates Z, Martin C, Boyd L, Ng X, Skinner V, et al., 'Gene-Nutrient Interaction between Folate and Dihydrofolate Reductase in Risk for Adenomatous Polyp Occurrence: A Preliminary Report', JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 61 455-459 (2015) [C1]
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Nova |
2015 |
Choi JH, Yates Z, Martin C, Boyd L, Ng X, Skinner V, et al., 'Genetic variation in glutamate carboxypeptidase II and interaction with dietary natural vitamin C may predict risk for adenomatous polyp occurrence', Asian Pacific Journal of Cancer Prevention, 16 4383-4386 (2015) [C1]
Background: The C1561T variant of the glutamate carboxypeptidase II (GCPII) gene is critical for natural methylfolylpolyglutamte (methylfolate) absorption, and has been associated... [more]
Background: The C1561T variant of the glutamate carboxypeptidase II (GCPII) gene is critical for natural methylfolylpolyglutamte (methylfolate) absorption, and has been associated with perturbations in folate metabolism and disease susceptibility. However, little is known on C1561T-GCPII as a risk factor for colorectal cancer. Therefore, this study examined whether C1561T-GCPII influences folate metabolism and adenomatous polyp occurrence. Materials and Methods: 164 controls and 38 adenomatous polyp cases were analysed to determine blood folate and plasma homocysteine (Hcy) level, dietary intake of natural methylfolate, synthetic pteroylglutamic acid (PteGlu), vitamin C and C1561T-GCPII genotype. Results: In controls and cases, 7.3 and 18.4 percent of subjects respectively, were found to have the CT genotype, increasing the risk for adenomatous polyp occurrence 2.86 times (95% CI:1.37-8.0, p=0.035). Total dietary folate, methylfolate and PteGlu intake and the level of erythrocyte folate and plasma Hcy did not predict the occurrence of an adenomatous polyp. However, dietary natural vitamin C intake was associated with adenomatous polyp risk within C1561T-GCPII CT genotype subjects (p=0.037). Conclusions: The findings suggest that C1561T-GCPII variation may be associated with risk for adenomatous polyp, and vitamin C may modify risk by interacting with the variant gene, its expression product and/or folate substrates.
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Nova |
2015 |
Beckett EL, Martin C, Duesing K, Jones P, Furst J, Yates Z, et al., 'Vitamin D receptor genotype modulates the correlation between vitamin D and circulating levels of let-7a/b and vitamin D intake in an elderly cohort', Journal of Nutrigenetics and Nutrigenomics, 7 264-273 (2015) [C1]
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Nova |
2015 |
Beckett EL, Martin C, Choi JH, King K, Niblett S, Boyd L, et al., 'Folate status, folate-related genes and serum miR-21 expression: Implications for miR-21 as a biomarker', BBA Clinical, 4 45-51 (2015) [C1]
Background: Free circulating microRNA (miRNA) in serum may be valuable biomarkers for disease diagnosis and prognosis. miR-21, the archetypal oncogenic miRNA, has been proposed as... [more]
Background: Free circulating microRNA (miRNA) in serum may be valuable biomarkers for disease diagnosis and prognosis. miR-21, the archetypal oncogenic miRNA, has been proposed as a biomarker for colorectal cancer and its benign precursor, adenomatous polyps. However, it is now becoming clear that circulating miRNA profiles may be sensitive to lifestyle and environmental influences. Dietary components involved in one-carbon metabolism are particularly well placed to modulate miRNA expression through an influence on DNA methylation pathways. Methods: We investigated the role of methyl group donors (folate, B12, cysteine, homocysteine), polymorphisms of the enzymes of one-carbon metabolism, and serum miR-21 expression in a primary case-control cohort (colonoscopy confirmed adenomatous colon polyps vs controls; n. =. 253) and a secondary cross-sectional cohort (over 65s; n. =. 649). The relationships between these parameters and serum miR-21 levels were assessed, stratified by gender. Conclusions: Serum miR-21 expression was related to occurrence of adenomatous polyps in females, but not males. Folate levels and MTHFR-C677T genotype was associated with miR-21 expression in both genders. Additionally, DHFR-19 del and MSR-A66G were associated with miR-21 expression in females and males, respectively. Stimulation with excess folate increased expression of miR-21 in colon cancer cell lines. General significance: This study demonstrates that serum miR-21 expression correlates with folate status and related genetic status. This may have consequences for the proposed use of miR-21 as a colorectal cancer biomarker.
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Nova |
2015 |
Beckett EL, Le Gras KC, Veysey M, Boyd L, Ng X, Yates Z, et al., 'Vitamin D receptor polymorphism Fok1 alters risk for adenomatous polyps in Australian males', Journal of Nutrigenetics and Nutrigenomics, 8 2-2 (2015)
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2014 |
Choi JH, Yates Z, Veysey M, Heo YR, Lucock M, 'Contemporary issues surrounding folic acid fortification initiatives', Preventive Nutrition and Food Science, 19 247-260 (2014) [C1]
The impact of folate on health and disease, particularly pregnancy complications and congenital malformations, has been extensively studied. Mandatory folic acid fortification the... [more]
The impact of folate on health and disease, particularly pregnancy complications and congenital malformations, has been extensively studied. Mandatory folic acid fortification therefore has been implemented in multiple countries, resulting in a reduction in the occurrence of neural tube defects. However, emerging evidence suggests increased folate intake may also be associated with unexpected adverse effects. This literature review focuses on contemporary issues of concern, and possible underlying mechanisms as well as giving consideration the future direction of mandatory folic acid fortification. Folate fortification has been associated with the presence of unmetabolized folic acid (PteGlu) in blood, masking of vitamin B12 deficiency, increased dosage for anti-cancer medication, photo-catalysis of PteGlu leading to potential genotoxicity, and a role in the pathoaetiology of colorectal cancer. Increased folate intake has also been associated with twin birth and insulin resistance in offspring, and altered epigenetic mechanisms of inheritance. Although limited data exists to elucidate potential mechanisms underlying these issues, elevated blood folate level due to the excess use of PteGlu without consideration of an individual's specific phenotypic traits (e.g. genetic background and undiagnosed disease) may be relevant. Additionally, the accumulation of unmetabolized PteGlu may lead to inhibition of dihydrofolate reductase and other enzymes. Concerns notwithstanding, folic acid fortification has achieved enormous advances in public health. It therefore seems prudent to target and carefully monitor high risk groups, and to conduct well focused further research to better understand and to minimize any risk of mandatory folic acid fortification.
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Nova |
2014 |
Martin C, Yates Z, Veysey M, Lucock MD, 'Vitamin D Receptor Genetics and Calcium Intake in an Elderly Australian Cohort with Osteoporosis', Journal of Nutrigenetics and Nutrigenomics, 7 35-35 (2014)
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2014 |
Beckett EL, Veysey M, Ng X, Boyd L, Tang S, Yates Z, et al., 'Bitter taste phenotype better predicts folate status than tas2r38 bitter receptor genotype alone in a colonoscopy cohort', Journal of Nutrition & Intermediary Metabolism, 1 13-14 (2014)
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2014 |
Yates Z, Lucock MD, Beckett E, Veysey M, 'B-vitamins and cognition - food for thought', NEUROLOGY, (2014)
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2014 |
Beckett E, Martin C, Duesing K, Yates Z, Veysey M, Lucock MD, 'Vitamin D Receptor Genotype Modulates the Correlation Between Circulating Levels of miR-7a/b and Vitamin D Intake in an Elderly Cohort.', Journal of Nutrigenetics and Nutrigenomics, 7 10-10 (2014)
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2014 |
Drever J, Veysey M, Lucock MD, Niblett S, King K, MacDonald-Wicks L, Garg ML, 'Association between n-3 PUFA and blood lipid profile in older Australians.', Journal of Nutrition & Intermediary Metabolism, 1 31-31 (2014)
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2014 |
Abbott K, Veysey M, Lucock MD, Niblett S, King K, MacDonald-Wicks L, Garg ML, 'N-3 pufa status is inversely associated with type 2 diabetes mellitus in older Australians.', Journal of Nutrition & Intermediary Metabolism, 1 31-31 (2014)
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2014 |
Mingay E, Veysey M, Lucock MD, Niblett S, King K, Patterson A, Garg ML, 'Erythrocyte long chain n-3 pufa level is a predictor of body weight status in older Australians.', Journal of Nutrition & Intermediary Metabolism, 1 8-9 (2014)
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2014 |
Olliver M, Veysey M, Lucock MD, Niblett S, King K, MacDonald-Wicks L, Garg ML, 'Erythrocyte n-3pufa levels predict inflammatory status in older Australians.', Journal of Nutrition & Intermediary Metabolism, 1 10-10 (2014)
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2014 |
Rose M, Veysey M, Lucock MD, Niblett S, King K, Baines S, Garg ML, 'N-3 pufa status predicts non-alcoholic fatty liver disease (NAFLD) in older Australians.', Journal of Nutrition & Intermediary Metabolism, 1 9-9 (2014)
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2014 |
Lucock MD, Martin CE, Yates ZR, Veysey M, 'Diet and Our Genetic Legacy in the Recent Anthropocene: A Darwinian Perspective to Nutritional Health', Journal of Evidence-Based Complementary and Alternative Medicine, 19 68-83 (2014) [C1]
Nutrient-gene research tends to focus on human disease, although such interactions are often a by-product of our evolutionary heritage. This review explores health in this context... [more]
Nutrient-gene research tends to focus on human disease, although such interactions are often a by-product of our evolutionary heritage. This review explores health in this context, reframing genetic variation/epigenetic phenomena linked to diet in the framework of our recent evolutionary past. This "Darwinian/evolutionary medicine" approach examines how diet helped us evolve among primates and to adapt (or fail to adapt) our metabolome to specific environmental conditions leading to major diseases of civilization. This review presents updated evidence from a diet-gene perspective, portraying discord that exists with respect to health and our overall nutritional, cultural, and activity patterns. While Darwinian theory goes beyond nutritional considerations, a significant component within this concept does relate to nutrition and the mismatch between genes, modern diet, obesogenic lifestyle, and health outcomes. The review argues that nutritional sciences should expand knowledge on the evolutionary connection between food and disease, assimilating it into clinical training with greater prominence. © The Author(s) 2013.
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Nova |
2014 |
Lucock M, Yates Z, Martin C, Choi JH, Boyd L, Tang S, et al., 'Vitamin D, folate, and potential early lifecycle environmental origin of significant adult phenotypes.', Evolution, Medicine, and Public Health, 2014 69-91 (2014) [C1]
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Nova |
2014 |
Martin CE, Veysey M, Yates Z, Lucock MD, 'Vitamin D: Genetics, Environment & Health', Food and Nutritional Disorders, 3 1-19 (2014) [C1]
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Nova |
2013 |
Lucock M, Leeming R, 'Autism, seasonality and the environmental perturbation of epigenome related vitamin levels', Medical Hypotheses, 80 750-755 (2013) [C1]
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Nova |
2013 |
Lucock MD, Martin C, Boyd L, Naumovski N, Roach P, Yates Z, Veysey M, 'Response to 'calcium, phosphate and the risk of cardiovascular events and all-cause mortality in a population with stable coronary heart disease'', HEART, 99 349-350 (2013) [C3]
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2013 |
Lucock M, Yates Z, Boyd L, Naylor C, Choi J, Ng X, et al., 'Vitamin C-related nutrient-nutrient and nutrient-gene interactions that modify folate status', European Journal of Nutrition, 52 569-582 (2013) [C1]
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Nova |
2013 |
Lucock M, Yates Z, Martin C, Choi J, Boyd L, Tang S, et al., 'Hydrogen sulphide-related thiol metabolism and nutrigenetics in relation to hypertension in an elderly population', Genes & Nutrition, 8 221-229 (2013) [C1]
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Nova |
2012 |
Lucock MD, 'Dietary supplements and altered mortality: A conflict of evolutionary medicine', Archives of Internal Medicine, 172 448-449 (2012) [C3]
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2012 |
Lucock MD, Glanville T, Yates ZR, Walker J, Furst JE, Simpson N, 'Solar cycle predicts folate-sensitive neonatal genotypes at discrete phases of the first trimester of pregnancy: A novel folate-related human embryo loss hypothesis', Medical Hypotheses, 79 210-215 (2012) [C1]
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Nova |
2011 |
Lucock MD, Ng X, Boyd L, Skinner VM, Wai R, Tang S, et al., 'TAS2R38 bitter taste genetics, dietary vitamin C, and both natural and synthetic dietary folic acid predict folate status, a key micronutrient in the pathoaetiology of adenomatous polyps', Food & Function, 2 457-465 (2011) [C1]
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Nova |
2011 |
Lucock M, 'Folic acid: Beyond metabolism', Journal of Evidence-Based Complementary and Alternative Medicine, 16 102-113 (2011) [C3]
Mandatory and discretionary fortification with folic acid is eliminating deficiency of this vitamin. Blood levels of the vitamin have never been higher, with hematologic folate va... [more]
Mandatory and discretionary fortification with folic acid is eliminating deficiency of this vitamin. Blood levels of the vitamin have never been higher, with hematologic folate values commonly exceeding the upper range of calibration. The synthetic analog (pteroylmonoglutamic acid) prevents neural tube defects and lowers homocysteine, both positive attributes, yet negative correlates of pteroylmonoglutamic acid are increasingly reported. These involve increased risk for common cancers (ie, colon, breast, prostate) and antimetabolite effects on natural killer cells and at dihydrofolate reductase, a critical gatekeeper enzyme. This review, however, takes a different, human ecological perspective, examining novel folate-related phenomena distinct from the classic metabolic role of the vitamin in maintaining health and well-being. An argument is developed that at molecular, cellular, and organism levels, folate is crucial to some important events that link light to life. © The Author(s) 2011.
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2011 |
Lucock MD, 'Folic acid: Beyond metabolism', Journal of Evidence-Based Complementary and Alternative Medicine, 16 102-113 (2011) [C1]
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Nova |
2010 |
Lucock MD, Glanville T, Ovadia L, Yates ZR, Walker J, Simpson N, 'Photoperiod at conception predicts C677T-MTHFR genotype: A novel gene-environment interaction', American Journal of Human Biology, 22 484-489 (2010) [C1]
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Nova |
2010 |
Naumovski N, Veysey M, Ng X, Boyd L, Dufficy L, Blades BL, et al., 'The folic acid endophenotype and depression in an elderly population', Journal of Nutrition, Health and Aging, 14 829-833 (2010) [C1]
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Nova |
2009 |
Ng X, Boyd L, Dufficy L, Naumovski N, Blades BL, Travers C, et al., 'Folate nutritional genetics and risk for hypertension in an elderly population sample', Journal of Nutrigenetics and Nutrigenomics, 2 1-8 (2009) [C1]
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Nova |
2009 |
Smith DR, Lucock MD, 'Should folate supplements be integrated with workplace nutrition programs?', Industrial Health, 47 449-451 (2009) [C3]
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Nova |
2009 |
Leeming RJ, Lucock MD, 'Autism: Is there a folate connection?', Journal of Inherited Metabolic Disease, 32 400-402 (2009) [C2]
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Nova |
2009 |
Sohn K-J, Jang H, Campan M, Weisenberger DJ, Dickhout J, Wang Y-C, et al., 'The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: A possible molecular basis for the site-specific cancer risk modification', International Journal of Cancer, 124 1999-2005 (2009) [C1]
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Nova |
2009 |
Lucock MD, Yates ZR, 'Folic acid fortification: A double-edged sword', Current Opinion in Clinical Nutrition & Metabolic Care, 12 555-564 (2009) [C1]
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Nova |
2008 |
Ng X, Lucock M, Veysey M, 'Physicochemical effect of pH and antioxidants on mono- and triglutamate forms of 5-methyltetrahydrofolate, and evaluation of vitamin stability in human gastric juice: Implications for folate bioavailability (vol 106, pg 200, 2008)', FOOD CHEMISTRY, 110 1000-1000 (2008) [C3]
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2008 |
Ng X, Lucock MD, Veysey MJ, 'Physicochemical effect of pH and antioxidants on mono- and triglutamate forms of 5-methyltetrahydrofolate, and evaluation of vitamin stability in human gastric juice: Implications for folate bioavailability', Food Chemistry, 106 200-210 (2008) [C1]
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Nova |
2007 |
Adams MC, Lucock MD, Stuart JE, Fardell S, Baker K, Ng X, 'Preliminary evidence for involvement of the folate gene polymorphism 19 bp deletion-DHFR in occurrence of autism', Neuroscience Letters, 422 24-29 (2007) [C1]
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2007 |
Lucock MD, Yates ZR, Ng X, Veysey MJ, Blades BL, Travers C, et al., 'Preliminary evidence for genetic selection of 677T-MTHFR by natural annual cycle of folate abundance', Journal of Nutrigenetics and Nutrigenomics, 1 24-29 (2007) [C1]
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Nova |
2006 |
Dufficy L, Naumovski N, Ng X, Blades BL, Yates ZR, Travers C, et al., 'G80A reduced folate carrier SNP influences the absorption and cellular translocation of dietary folate and its association with blood pressure in an elderly population', Life Sciences, 79 957-966 (2006) [C1]
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Nova |
2006 |
Glanville T, Yates ZR, Ovadia L, Walker JJ, Lucock MD, Simpson NAB, 'Fetal folate C677T methylenetetrahydrofolate reductase gene polymorphism and low birth weight', Journal of Obstetrics and Gynaecology, 26 11-14 (2006) [C1]
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2006 |
Lucock MD, Yates ZR, 'Synergy between 677 TT MTHFR genotype and related folate SNPs regulates homocysteine level', Nutrition Research, 26 180-185 (2006) [C1]
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2006 |
Lucock MD, 'Synergy of genes and nutrients: The case of homocysteine', Current Opinion in Clinical Nutrition and Metabolic Care, 9 748-756 (2006) [C1]
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2005 |
Lucock MD, Ng X, Veysey MJ, Yates ZR, 'Folic acid: An essential nutrient with added health benefits', Biologist, 52 21-27 (2005) [C1]
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Nova |
2005 |
Lucock MD, Roach PD, 'The antifolate activity of tea catechins (letter)', Cancer Research, 65 8573-8573 (2005) [C3]
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Nova |
2005 |
Lucock MD, Yates Z, 'Folic acid - vitamin and panacea or genetic time bomb?', Nature Reviews Genetics, 6 235-240 (2005) [C1]
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Nova |
2005 |
Yates ZR, Lucock MD, 'G80A reduced folate carrier SNP modulates cellular uptake of folate and affords protection against thrombosis via a non homocysteine related mechanism', Life Sciences, 77 2735-2742 (2005) [C1]
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2005 |
Lucock MD, Yates ZR, 'Human genetic selection by folates', Nature Reviews Genetics, 6 online (2005) [C3]
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2004 |
Sohn K-J, Croxford R, Yates ZR, Lucock MD, Kim Y-I, 'Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate', Journal of the National Cancer Institute, 96 134-144 (2004) [C1]
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Nova |
2004 |
Sohn K-J, Smirnakis F, Moskovitz DN, Novakovic P, Yates ZR, Lucock MD, et al., 'Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate', GUT, 53 1825-1831 (2004) [C1]
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Nova |
2004 |
Blackburn A, Bibby MC, Lucock MD, Nicolaou A, 'Temporal evaluation of methionine synthase and related metabolites in the MAC15A mouse adenocarcinoma animal model', International Journal of Cancer, 112 577-584 (2004) [C1]
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2004 |
Lucock MD, 'Is folic acid the ultimate functional food component for disease prevention?', British Medical Journal, 328 211-214 (2004) [C1]
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Nova |
2004 |
Lucock M, 'Is folic acid the ultimate functional food component for disease prevention?', BMJ, 328 211-214 (2004)
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2004 |
Lucock MD, 'Is folic acid the ultimate functional food component for disease prevention?', BMJ USA, 4 127-130 (2004) [C1] |
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2003 |
Lucock MD, Yates ZR, Glanville T, Leeming R, Simpson N, Daskalakis I, 'A critical role for B-vitamin nutrition in human developmental and evolutionary biology', Nutrition Research, 23 1463-1475 (2003) [C1]
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2003 |
Yates Z, Lucock M, 'Interaction between common folate polymorphisms and B-vitamin nutritional status modulates homocysteine and risk for a thrombotic event', MOLECULAR GENETICS AND METABOLISM, 79 201-213 (2003) [C1]
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2002 |
Lucock M, Yates Z, 'Correspondence: Measurement of red blood cell methylfolate', Lancet, 360 (2002) [C3] |
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2002 |
Lucock M, Yates Z, 'Measurement of red blood cell methylfolate', LANCET, 360 1021-1022 (2002) [C1]
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2002 |
Yates Z, Lucock M, 'Methionine synthase, polymorphism A2756G is associated with susceptibility for thromboembolic events and altered B vitamin/thiol metabolism', HAEMATOLOGICA, 87 751-756 (2002) [C1]
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2002 |
Lucock M, Yates Z, Hall K, Leeming R, Rylance G, MacDonald A, Green A, 'The impact of phenylketonuria on folate metabolism', MOLECULAR GENETICS AND METABOLISM, 76 305-312 (2002) [C1]
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2002 |
Lucock M, Yates Z, Hall K, Leeming R, Rylance G, MacDonald A, Green A, 'The impact of phenylketonuria on folate metabolism', Molecular Genetics and Metabolism, 1096-7206 (2002) [C1] |
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2002 |
Glanville T, Yates Z, Ovadia L, Walker JJ, Lucock MD, Simpson NAB, 'Folate gene Polymorphism and fetal growth restriction.', British Journal of Obstetrics and Gynaecology, 109 481-481 (2002)
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2001 |
Lucock M, Daskalakis I, Yates Z, 'C677T MTHFR genotypes show graded response to vitamin B-12 dependent regeneration of tetrahydrofolate, the main congener of all cellular folates', NUTRITION RESEARCH, 21 1357-1362 (2001) [C1]
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2001 |
Lucock M, Yates Z, Daskalakis I, 'C677T MTHFR genotypes show graded response to vitamin B12 dependent regeneration of tetrahydrofolate, the main congenor of all cellular folates', Nutrition Research, 0271-5317 (2001) [C1] |
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2001 |
Lucock M, Daskalakis I, Hinkins M, Yates Z, 'An examination of polymorphic genes and folate metabolism in mothers affected by a spina bifida pregnancy', MOLECULAR GENETICS AND METABOLISM, 73 322-332 (2001) [C1]
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2001 |
Lucock M, Daskalakis I, Hinkins M, Yates Z, 'An examination of polymorphic genes and folate metabolism in mothers affected by a spina bifida pregnancy', Molecular Genetics and Metabolism, 1096-7206 (2001) [C1] |
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2001 |
Lucock M, Yates Z, 'Update on folic acid and neural tube defects: 'Comment' article', Clinical Nutrition, 10 25-33 (2001) [C1]
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2001 |
Lucock MD, Yates Z, Cade A, '12 Channel coulometric electrochemical detection for the identification of polyglutamate homology amongst cellular folates.', PTERIDINES, 12 59-59 (2001)
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2001 |
Yates Z, Lucock MD, 'C677T MTHFR genotype is a risk factor for thromboembolism: comparison of T allele frequency and homocysteine level between female thromboembolic and non-thromboembolic vascular patients, NTD mothers and matched NTD controls.', PTERIDINES, 12 92-92 (2001)
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2001 |
Lucock MD, Yates Z, Cade A, 'Gastro-intestinal pH modulates facile interconvertion of native formylfolates during absorption.', PTERIDINES, 12 60-60 (2001)
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2000 |
Lucock M, Daskalakis I, 'New perspectives on folate status: a differential role for the vitamin in cardiovascular disease, birth defects and other conditions', BRITISH JOURNAL OF BIOMEDICAL SCIENCE, 57 254-260 (2000)
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2000 |
Lucock M, Daskalakis I, Briggs D, Yates Z, Levene M, 'Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: Influence of 677c -\ t methylenetetrahydrofolate reductase and 2756a -\ g methionine synthase genotypes', MOLECULAR GENETICS AND METABOLISM, 70 27-44 (2000) [C1]
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2000 |
Lucock M, 'Folic acid: Nutritional biochemistry, molecular biology, and role in disease processes', MOLECULAR GENETICS AND METABOLISM, 71 121-138 (2000)
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1999 |
Lucock MD, Daskalakis I, Schorah CJ, Lumb CH, Oliver M, Devitt H, et al., 'Folate-homocysteine interrelations: Potential new markers of folate status', MOLECULAR GENETICS AND METABOLISM, 67 23-35 (1999)
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1999 |
Lucock MD, 'Food fortification with folic acid', eBMJ, (1999) |
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1998 |
Schorah CJ, Devitt H, Lucock M, Dowell AC, 'The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study', EUROPEAN JOURNAL OF CLINICAL NUTRITION, 52 407-411 (1998)
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1998 |
Lucock MD, Daskalakis I, Lumb CH, Schorah CJ, Levene MI, 'Impaired regeneration of monoglutamyl tetrahydrofolate leads to cellular folate depletion in mothers affected by a spina bifida pregnancy', MOLECULAR GENETICS AND METABOLISM, 65 18-30 (1998)
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1998 |
Lucock MD, 'What is meant by folic acid and folate status.', BRITISH JOURNAL OF BIOMEDICAL SCIENCE, 55 54-54 (1998) |
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1997 |
Lucock MD, Wild J, Lumb CH, Oliver M, Kendall R, Daskalakis I, et al., 'Risk of neural tube defect-affected pregnancy is associated with a block in maternal one-carbon metabolism at the level of N-5-methyltetrahydrofolate:homocysteine methyltransferase', BIOCHEMICAL AND MOLECULAR MEDICINE, 61 28-40 (1997)
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1997 |
Lucock MD, Lumb CH, Wild J, Daskalakis I, Schorah CJ, Kendall R, Levene MI, 'Methyl group utilisation versus production in NTD and control subjects: Influence of vitamin B12.', PTERIDINES, 8 156-157 (1997) |
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1997 |
Lucock MD, Lumb CH, Wild J, Oliver M, Daskalakis I, Schorah CJ, et al., 'Elevated homocysteine in subjects with a previous NTD pregnancy is associated with increased hexaglutamyl methylfolate consistent with impaired B12 Dependant Methionine Synthase activity.', PTERIDINES, 8 85-86 (1997) |
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1997 |
Lucock MD, Daskalakis I, Lumb CH, OLIVER M, Wild J, Schorah CJ, Levene MI, 'One carbon metabolic parameters and NTD', PTERIDINES, 8 155-155 (1997) |
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1997 |
Lucock MD, Lumb CH, Wild J, Oliver M, Daskalakis I, Schorah CJ, et al., 'Methionine synthase activity is dependant upon intracellular methylfolate levels in control but not NTD subjects where utilisation of hexaglutamyl methylfolate is limiting for remethylation of homocysteine.', PTERIDINES, 8 156-156 (1997) |
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1996 |
Schorah CJ, Wild J, Lucock M, 'Folate dose may mask small differences in folate metabolism', AMERICAN JOURNAL OF CLINICAL NUTRITION, 63 976-976 (1996) |
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1996 |
Daskalakis I, Lucock MD, Anderson A, Wild J, Schorah CJ, Levene MI, 'Determination of plasma total homocysteine and cysteine using HPLC with fluorescence detection and an ammonium 7-fluoro-2,1,3-benzoxadiazole-4-sulphonate (SBD-F) derivatization protocol optimized for antioxidant concentration, derivatization reagent concentration, temperature and matrix pH', BIOMEDICAL CHROMATOGRAPHY, 10 205-212 (1996)
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1996 |
Lucock MD, Daskalakis I, Schorah CJ, Levene MI, Hartley R, 'Analysis and biochemistry of blood folate', BIOCHEMICAL AND MOLECULAR MEDICINE, 58 93-112 (1996)
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1996 |
Lucock MD, Daskalakis IG, Wild J, Anderson A, Schorah CJ, Lean MEJ, Levene MI, 'The influence of dietary folate and methionine on the metabolic disposition of endotoxic homocysteine', BIOCHEMICAL AND MOLECULAR MEDICINE, 59 104-111 (1996)
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1995 |
LUCOCK MD, GREEN M, PRIESTNALL M, DASKALAKIS I, LEVENE MI, HARTLEY R, 'OPTIMIZATION OF CHROMATOGRAPHIC CONDITIONS FOR THE DETERMINATION OF FOLATES IN FOODS AND BIOLOGICAL TISSUES FOR NUTRITIONAL AND CLINICAL-WORK', FOOD CHEMISTRY, 53 329-338 (1995)
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1995 |
LUCOCK MD, GREEN M, LEVENE MI, 'METHYLFOLATE MODULATES POTASSIUM-EVOKED NEURO-SECRETION - EVIDENCE FOR A ROLE AT THE PTERIDINE COFACTOR LEVEL OF TYROSINE 3-HYDROXYLASE', NEUROCHEMICAL RESEARCH, 20 727-736 (1995)
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1995 |
LUCOCK MD, PRIESTNALL M, DASKALAKIS I, SCHORAH CJ, WILD J, LEVENE MI, 'NONENZYMATIC DEGRADATION AND SALVAGE OF DIETARY-FOLATE - PHYSICOCHEMICAL FACTORS LIKELY TO INFLUENCE BIOAVAILABILITY', BIOCHEMICAL AND MOLECULAR MEDICINE, 55 43-53 (1995)
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1995 |
WILD J, LUCOCK MD, SCHORAH CJ, 'PERICONCEPTIONAL FOLATE AND NEURAL-TUBE DEFECTS', AMERICAN JOURNAL OF CLINICAL NUTRITION, 61 615-616 (1995)
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1995 |
HABIBZADEH N, WILD J, LUCOCK MD, SCHORAH CJ, 'ONE-CARBON METABOLISM IN PREGNANCIES COMPLICATED BY NEURAL-TUBE DEFECTS', LANCET, 345 791-791 (1995)
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1995 |
LUCOCK MD, WILD J, LEVENE MI, 'ENZYME DEFECT AS A RISK FACTOR FOR SPINA-BIFIDA', LANCET, 346 1495-1496 (1995)
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1994 |
LUCOCK MD, NAYEEMUDDIN FA, HABIBZADEH N, SCHORAH CJ, HARTLEY R, LEVENE MI, 'METHYLFOLATE EXHIBITS A NEGATIVE IN-VITRO INTERACTION WITH IMPORTANT DIETARY METAL-CATIONS', FOOD CHEMISTRY, 50 307-310 (1994)
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1994 |
LUCOCK MD, WILD J, SCHORAH CJ, LEVENE MI, HARTLEY R, 'THE METHYLFOLATE AXIS IN NEURAL-TUBE DEFECTS - IN-VITRO CHARACTERIZATION AND CLINICAL INVESTIGATION', BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY, 52 101-114 (1994)
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1993 |
LUCOCK MD, GREEN M, HARTLEY R, LEVENE MI, 'PHYSICOCHEMICAL AND BIOLOGICAL FACTORS INFLUENCING METHYLFOLATE STABILITY - USE OF DITHIOTHREITOL FOR HPLC ANALYSIS WITH ELECTROCHEMICAL DETECTION', FOOD CHEMISTRY, 47 79-86 (1993)
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1993 |
LUCOCK MD, LEVENE MI, HARTLEY R, 'MODULATION OF POTASSIUM EVOKED SECRETORY FUNCTION IN RAT CEREBELLAR SLICES MEASURED BY REAL-TIME MONITORING - EVIDENCE OF A POSSIBLE ROLE FOR METHYLFOLATE IN CEREBRAL TISSUE', NEUROCHEMICAL RESEARCH, 18 617-623 (1993)
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1991 |
LUCOCK MD, WILD J, HARTLEY R, LEVENE MI, SCHORAH CJ, 'VITAMINS TO PREVENT NEURAL-TUBE DEFECTS', LANCET, 338 894-895 (1991)
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1991 |
HARTLEY R, GREEN M, LUCOCK MD, RYAN S, FORSYTHE WI, 'SOLID-PHASE EXTRACTION OF OXCARBAZEPINE AND ITS METABOLITES FROM PLASMA FOR ANALYSIS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY', BIOMEDICAL CHROMATOGRAPHY, 5 212-215 (1991)
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1991 |
HARTLEY R, FORSYTHE WI, MCLAIN B, NG PC, LUCOCK MD, 'DAILY VARIATIONS IN STEADY-STATE PLASMA-CONCENTRATIONS OF CARBAMAZEPINE AND ITS METABOLITES IN EPILEPTIC CHILDREN', CLINICAL PHARMACOKINETICS, 20 237-244 (1991)
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1990 |
HARTLEY R, LUCOCK MD, NG PC, FORSYTHE WI, MCLAIN B, BOWMER CJ, 'FACTORS INFLUENCING PLASMA-LEVEL DOSE RATIOS OF CARBAMAZEPINE AND ITS MAJOR METABOLITES IN EPILEPTIC CHILDREN', THERAPEUTIC DRUG MONITORING, 12 438-444 (1990)
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1989 |
LUCOCK MD, HARTLEY R, SMITHELLS RW, 'A RAPID AND SPECIFIC HPLC-ELECTROCHEMICAL METHOD FOR THE DETERMINATION OF ENDOGENOUS 5-METHYLTETRAHYDROFOLIC ACID IN PLASMA USING SOLID-PHASE SAMPLE PREPARATION WITH INTERNAL STANDARDIZATION', BIOMEDICAL CHROMATOGRAPHY, 3 58-63 (1989)
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1989 |
LUCOCK MD, WILD J, SMITHELLS RW, HARTLEY R, 'INVIVO CHARACTERIZATION OF THE ABSORPTION AND BIOTRANSFORMATION OF PTEROYLMONOGLUTAMIC ACID IN MAN - A MODEL FOR FUTURE STUDIES', BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY, 42 30-42 (1989)
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1989 |
LUCOCK M, WILD J, SMITHELLS R, HARTLEY R, 'BIOTRANSFORMATION OF PTEROYLMONOGLUTAMIC ACID DURING ABSORPTION - IMPLICATIONS OF MICHAELIS-MENTEN KINETICS', EUROPEAN JOURNAL OF CLINICAL NUTRITION, 43 631-635 (1989)
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1988 |
Forsythe WI, Hartley R, Lucock MD, McClain B, Ng P, 'Diurnal variation of carbamazepine plasma levels in epileptic children at steady state: Clinical implications and interpretations.', IRISH JOURNAL OF MEDICAL SCIENCE, 278-278 (1988) |
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1987 |
LUCOCK M, HARTLEY R, WILD NJ, 'HPLC DETERMINATION OF VITAMIN-K1 IN NEONATAL PLASMA FOLLOWING ORAL OR PARENTERAL SUPPLEMENTATION WITH KONAKION', JOURNAL OF LIQUID CHROMATOGRAPHY, 10 191-203 (1987)
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1987 |
HARTLEY R, LUCOCK M, FORSYTHE WI, SMITHELLS RW, 'SOLID-PHASE EXTRACTION OF CARBAMAZEPINE AND 2 MAJOR METABOLITES FROM PLASMA FOR ANALYSIS BY HPLC', JOURNAL OF LIQUID CHROMATOGRAPHY, 10 2393-2409 (1987)
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1987 |
HARTLEY R, LUCOCK M, BECKER M, 'IMPROVED HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC PROCEDURE FOR THE DETERMINATION OF CHLORMETHIAZOLE LEVELS FOLLOWING SOLID-PHASE EXTRACTION FROM PLASMA', JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 415 357-364 (1987)
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1986 |
PICKARD CE, STEWART AD, HARTLEY R, LUCOCK MD, 'A RAPID HPLC METHOD FOR MONITORING PLASMA-LEVELS OF CAFFEINE AND THEOPHYLLINE USING SOLID-PHASE EXTRACTION COLUMNS', ANNALS OF CLINICAL BIOCHEMISTRY, 23 440-446 (1986)
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1986 |
HARTLEY R, LUCOCK M, BECKER M, SMITH IJ, FORSYTHE WI, 'SOLID-PHASE EXTRACTION OF ACETAZOLAMIDE FROM BIOLOGICAL-FLUIDS AND SUBSEQUENT ANALYSIS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY', JOURNAL OF CHROMATOGRAPHY, 377 295-305 (1986)
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1986 |
HARTLEY R, LUCOCK M, COOKMAN JR, BECKER M, SMITH IJ, SMITHELLS RW, FORSYTHE WI, 'HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF CARBAMAZEPINE AND CARBAMAZEPINE 10,11-EPOXIDE IN PLASMA AND SALIVA FOLLOWING SOLID-PHASE SAMPLE EXTRACTION', JOURNAL OF CHROMATOGRAPHY, 380 347-356 (1986)
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