Profile Image

Associate Professor Mark Lucock

Associate Professor

School of Environmental and Life Sciences (Applied Sciences)

Career Summary

Biography

I arrived at the UoN in 2003. My formative academic years were spent at the University of Leeds, UK, where my lifetimes interest in vitamins, particularly folic acid, emerged out of the seminal work conducted by Leeds Paediatrician, Professor Dick Smithells. His work demonstrated how periconceptional folic acid supplementation could reduce the risk of neural tube defects like spina bifida. His work is considered to be one of the finest contemporary examples of preventative medicine.

Today, my overarching research interest is the role of diet in human ecology. I have established an international reputation in the field of nutritional genetics and epigenetics in relation to genes coding for proteins involved in vitamin D and folate/B vitamin metabolism and function. This is of major significance in defining important clinical phenotypes, and is of evolutionary and developmental relevance. As of June 2017, my authored publication list is 195 articles/chapters/books, and includes several very high impact factor (>20*) research articles (Nature*, Lancet*, BMJ, JNCI, PNAS). My total citation number is 3,036; the highest single paper citation count being 644 and my h index is 27. The scope of publications range from nutrient analysis and nutrient gene interactions to the role of B vitamins and vitamin D in human disease and evolutionary processes. A major theme throughout my career has been on developmental and degenerative conditions related to these vitamins (especially folic acid); in particular, studies have focused on birth defects, pregnancy complications, colon cancer, mood disorders, dementia, autism and cardiovascular disease. I've published several articles in each of these areas.

In 2007 I was sole author of an academic text book for students and researchers titled – Molecular Nutrition and Genomics: Nutrition & the Ascent of Humankind (Wiley). Most importantly, my research publications demonstrate extensive international collaboration (UK, Canada and US), have significant bearing on the fundamental mechanisms underpinning human disease and evolutionary processes, and have been reported in some very high profile journals and media.

Condensing my life's research focus into a single statement it would read: Vitamin biology (B vitamins, and vitamin D) and nutrigenetics, taking a lifecycle approach to human health with a focus on both developmental and degenerative disorders, to include the exposome and how it might interact with genes to alter human biology and disease.

More specific research foci include:

> Role of diet in human ecology (health, disease and evolutionary biology)

> Vitamin chemistry, biochemistry, genetics and evolutionary and health significance

> Vitamins in relation to common developmental and degenerative disorders (nutritional genetic perspective)

> Evolutionary medicine, particularly ancestral genes vs contemporary diet

> Developmental origins of adult disease/epigenetics

> Nutrients and healthy ageing

> Nutritional and natural product pharmacology

> Vitamin D, UV exposure and health

> Folic acid and its dependent genes in human biology

I am a Charted Biologist (CBiol), and an elected Fellow of the Royal Society of Biology (FRSB), London, a measure of esteem broadly equivalent to a DSc. I am also a Fellow of the Royal College of Pathologists (FRCPath), London, which is again a measure of esteem linked to research output.

In the years preceding my move to Australia in July 2003, I held around $450,000 AUD in funding. Since taking up my present position at the UoN, I have received 28 successful grants worth $1,247,181 against a career total of $1,692,701 (as of June 2017).

I have helped lead the establishment of a well equipped PC2 laboratory directed to molecular nutrition that includes real time PCR equipment, dHPLC, LCMS, an imaging platform and other key technologies, and which has recently expanded to include a broad repertoire of tissue culture methodologies. My UoN research/honours students include 10x Honours, 1x Intercalating BMedSci, 1x Masters, 10x PhD, 2xRA and 1x Fellow. Over my career this equates to 10x Honours, 12x PhD, 7x RAs, 7x Intercalating BMedSci students, 1x Masters, 1x Fellow.

Research Expertise

Vitamin Biology with a focus on folic acid and vitamin D. See above for specific research foci.

Teaching Expertise

I am convener for three courses in the Bachelor of Food Science & Human Nutrition Program, all of which I developed and deliver (Micronutrients, Biology of nutrients through the lifecycle, and Functional foods and health claims). In Dec 2005 I was recipient of the Faculty of Science and IT Teaching and Learning Award, and in 2006 I received the Vice Chancellor’s Citation for Outstanding Contributions to Student Learning. I was also a UoN nominee for the National Award of ‘Carrick Citation for Outstanding Contributions to Student Learning’.

Administrative Expertise

I have been Deputy Head of School, SACO, FR&RT & FT&L Committee member and Program Leader.

Collaborations
Many national and International (UK, USA, Canada) collaborators with significant and/or high impact joint research output. The majority of these relate to shared work in my core area of “folic acid chemistry, metabolism and genetics in health and disease”.


Qualifications

  • PhD, University of Leeds - UK
  • Bachelor of Science (Honours), University of Bradford, UK

Keywords

  • Ageing
  • B-Vitamins
  • Birth defects
  • Cancer
  • Developmental Origins
  • Diet in Human Ecology
  • Epigenetics
  • Evolutionary/Darwinian Medicine
  • Folic acid
  • Functional foods and health claims
  • Micronutrients
  • Molecular Nutrition
  • Nutrient bioavailability
  • Nutrition and Human Evolution
  • Nutrition through the lifecycle
  • Nutritional Biochemistry
  • Nutritional Genetics
  • Vascular disease
  • Vitamin B12
  • Vitamin D

Fields of Research

Code Description Percentage
111199 Nutrition and Dietetics not elsewhere classified 30
110399 Clinical Sciences not elsewhere classified 40
060499 Genetics not elsewhere classified 30

Professional Experience

UON Appointment

Title Organisation / Department
Associate Professor University of Newcastle
School of Environmental and Life Sciences
Australia

Academic appointment

Dates Title Organisation / Department
Fellow of the Royal College of Pathologists (FRCPath) Royal College of Pathologists, London
United Kingdom
Fellow of the Royal Society of Biology (FRSB) Royal Society of Biology, London
United Kingdom
1/01/2006 -  Scientific advisor - mandatory fortification of the Australian diet with folic acid FSANZ (Food standards Australia & New Zealand)
Australia

Professional appointment

Dates Title Organisation / Department
Chartered Biologist (CBiol) Royal Society of Biology, London
United Kingdom

Awards

Distinction

Year Award
2006 Vice-Chancellor's Citations for Outstanding Contributions to Student Learning
University of Newcastle

Recognition

Year Award
2005 Faculty of Science & IT Teaching & Learning Award
University of Newcastle

Invitations

Participant

Year Title / Rationale
2007 All invitations relate to folate
Organisation: Several both national and international Description: Invariably based on research expertise and interest in B-vitamins and health
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Book (1 outputs)

Year Citation Altmetrics Link
2007 Lucock MD, Molecular Nutrition and Genomics: Nutrition and the Ascent of Mankind, John Wiley & Sons, Hoboken, 140 (2007) [A1]
DOI 10.1002/9780470129388.fmatter

Chapter (3 outputs)

Year Citation Altmetrics Link
2017 Beckett EL, Veysey M, Lucock M, Joubert B, 'Maternal Folate and DNA Methylation in Offspring', Handbook of Nutrition, Diet, and Epigenetics, SpringerLink, USA (2017)
DOI 10.1007/978-3-319-31143-2_3-1
Co-authors Emma Beckett, Martin Veysey
2002 Lucock M, 'A differential role for folate in developmental disorders, vascular disease and other clinical conditions: the importance of folate status and genotype', , Humana Press, Totowa NJ, 263-298 (2002) [B1]
2000 Lucock MD, 'Folate Metabolism', Progress in Haematology Volume II, Greenwich Medical Media, London 1-30 (2000)

Journal article (128 outputs)

Year Citation Altmetrics Link
2017 Beckett EL, Veysey M, Lucock MD, 'Folate and microRNA: Bidirectional interactions', Clinica Chimica Acta, 474 60-66 (2017) [C1]
DOI 10.1016/j.cca.2017.09.001
Co-authors Emma Beckett, Martin Veysey
2017 Lucock M, Jones P, Veysey M, Beckett E, 'B vitamins and pollution, an interesting, emerging, yet incomplete picture of folate and the exposome', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114 E3878-E3879 (2017)
DOI 10.1073/pnas.1704662114
Citations Scopus - 1Web of Science - 1
Co-authors Patrice Jones, Martin Veysey, Emma Beckett
2017 Lucock M, Beckett E, Martin C, Jones P, Furst J, Yates Z, et al., 'UV-associated decline in systemic folate: implications for human nutrigenetics, health, and evolutionary processes', AMERICAN JOURNAL OF HUMAN BIOLOGY, 29 (2017) [C1]
DOI 10.1002/ajhb.22929
Citations Scopus - 2Web of Science - 2
Co-authors Zoe Yates, Martin Veysey, Emma Beckett, Patrice Jones, John Furst
2017 Beckett EL, Jones P, Veysey M, Duesing K, Martin C, Furst J, et al., 'VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences', AMERICAN JOURNAL OF HUMAN BIOLOGY, 29 (2017) [C1]
DOI 10.1002/ajhb.23010
Co-authors John Furst, Zoe Yates, Patrice Jones, Emma Beckett, Martin Veysey
2017 Beckett EL, Porter T, Boyd L, King K, Niblett S, Yates Z, et al., 'A TAS2R38 genotype dependent response to mandatory folic acid fortification: A comparison of two elderly cohorts.', Journal of Nutrition & Intermediary Metabolism, 8 84-84 (2017)
2017 Beckett EL, Martin C, Boyd L, Porter T, King K, Niblett S, et al., 'Reduced plasma homocysteine levels in elderly Australians following mandatory folic acid fortification ¿ A comparison of two cross-sectional cohorts', Journal of Nutrition and Intermediary Metabolism, 8 14-20 (2017) [C1]
DOI 10.1016/j.jnim.2017.04.001
Co-authors Katrina King, Emma Beckett, Zoe Yates, Martin Veysey
2017 Beckett EL, Duesing K, Boyd L, Yates Z, Veysey M, Lucock M, 'A potential sex dimorphism in the relationship between bitter taste and alcohol consumption', FOOD & FUNCTION, 8 1116-1123 (2017) [C1]
DOI 10.1039/c6fo01759b
Co-authors Emma Beckett, Martin Veysey, Zoe Yates
2016 Yates Z, Lucock M, Veysey M, Choi JH, 'Elevated folic acid results in contrasting cancer cell line growth with implications for mandatory folic acid fortification', Journal of Nutrition and Health, 49 72-79 (2016) [C1]

© 2016 The Korean Nutrition Society. Purpose: The initiation of mandatory folic acid fortification using pteroylmonoglutamic acid (PteGlu) has reduced the rate of congenital malf... [more]

© 2016 The Korean Nutrition Society. Purpose: The initiation of mandatory folic acid fortification using pteroylmonoglutamic acid (PteGlu) has reduced the rate of congenital malformations. However, it also appears to be responsible for several adverse effects, including increased cancer incidence. This may be related to physicho-chemical characteristics of PteGlu. This study examines the potential effect of high concentrations of PteGlu on a population subjected to mandatory folic acid fortification using an in vitro model. Methods: Caco-2 (colorectal cancer) and MCF7 (breast cancer) cell lines were cultured at 6 different PteGlu concentrations (0, 0.1, 1, 50, 250, and 500µg/ml) for 6 days. Cell growth was determined using thiazolyl blue tetrazolium bromide assay. The genotype of dihydrofolate reductase 19bp deletion/insertion (DHFR 19-del) was also scored in cell lines using a restriction fragment length polymorphism technique to examine whether genetic variations may factor in cell proliferation. Results: PteGlu exhibited differential growth promoting properties between cell lines. Caco-2 cells did not show a significant growth difference at low concentrations compared to control, however, at higher concentrations, the growth showed a contrasting trend in the early experimental period, while MCF7 showed enhanced cell growth at all concentrations. The DHFR 19-del genotype differed in the two cell lines. Conclusions: Altered response to PteGlu by Caco-2 and MCF7 may reflect a tissue specific disease aetiology or genotype specific differential enzyme activity, for example by DHFR, to critical levels of PteGlu. As folic acid fortification is a blanket intervention, and DHFR and other enzyme activities vary between individuals, PteGlu intake may have an as yet undefined effect on health. These findings may be relevant when considering mandatory folic acid fortification for disease prevention.

DOI 10.4163/jnh.2016.49.2.72
Co-authors Martin Veysey, Zoe Yates
2016 Jones P, Beckett EL, Yates Z, Veysey M, Lucock M, 'Converging Evolutionary, Environmental and Clinical Ideas on Folate Metabolism', Exploratory Research and Hypothesis in Medicine, 1 34-41 (2016) [C1]
DOI 10.14218/ERHM.2016.00003b
Co-authors Martin Veysey, Zoe Yates, Patrice Jones, Emma Beckett
2016 Beckett EL, Le Gras K, Martin C, Boyd L, Ng X, Duesing K, et al., 'Vitamin D receptor polymorphisms relate to risk of adenomatous polyps in a sex-specific manner', Nutrition and Cancer, 68 193-200 (2016) [C1]

© 2016 Taylor & Francis Group, LLC. Vitamin D receptor (VDR) gene polymorphisms may influence risk for adenomatous polyps (AP), a benign precursor to colon cancer, via modu... [more]

© 2016 Taylor & Francis Group, LLC. Vitamin D receptor (VDR) gene polymorphisms may influence risk for adenomatous polyps (AP), a benign precursor to colon cancer, via modulation of vitamin D sensitive pathways, including cell proliferation and differentiation. However, results have been mixed and any association remains contentious. Failure to clinically exclude the presence of (AP in control cohorts may contribute to the lack of consensus. Therefore, we assessed the role of the FokI, BsmI, ApaI, and TaqI VDR polymorphisms in modifying risk for AP, adjusting for a range of dietary and lifestyle variables. Blood was collected from colonoscopy patients (n = 258) and VDR polymorphisms assessed by restriction fragment length polymorphism. Dietary habits were estimated from food frequency questionnaires. Odds ratios for AP were calculated by genotype, stratified by sex, and adjusted for age, lifestyle, and dietary factors. FokI was associated with modified risk for AP in males, whereas the BsmI/ApaI/TaqI haplotype was associated with modified risk in females. No interaction was found between VDR variants and vitamin D intake. This study offers novel insight into the potential for VDR genetics to contribute to risk for AP and is the first to demonstrate a sex-specific relationship between these polymorphisms and risk for AP.

DOI 10.1080/01635581.2016.1142584
Citations Scopus - 2Web of Science - 2
Co-authors Zoe Yates, Emma Beckett, Martin Veysey
2016 Abbott KA, Veysey M, Lucock M, Niblett S, King K, Burrows T, Garg ML, 'Sex-dependent association between erythrocyte n-3 PUFA and type 2 diabetes in older overweight people.', Br J Nutr, 115 1379-1386 (2016) [C1]
DOI 10.1017/S0007114516000258
Citations Scopus - 1Web of Science - 1
Co-authors Tracy Burrows, Manohar Garg, Martin Veysey, Katrina King
2016 Beckett EL, Duesing K, Martin C, Jones P, Furst J, King K, et al., 'Relationship between methylation status of Vitamin D-related genes, Vitamin D levels, and methyl-donor biochemistry', Journal of Nutrition and Intermediary Metabolism, 6 8-15 (2016) [C1]

© 2016 The Authors. Published by Elsevier Inc. Vitamin D is known for its role in the regulation of gene expression via the Vitamin D receptor, a nuclear transcription factor. Mo... [more]

© 2016 The Authors. Published by Elsevier Inc. Vitamin D is known for its role in the regulation of gene expression via the Vitamin D receptor, a nuclear transcription factor. More recently, a role for Vitamin D in regulating DNA methylation has been identified as an additional mechanism of modulation of gene expression. How methylation status influences Vitamin D metabolism and response pathways is not yet clear. Therefore, we aimed to assess the relationship between plasma 25-hydroxycholecalciferol (25(OH)D) and the methylation status of Vitamin D metabolism enzyme genes (CYP2R1, CYP27B1 and CYP24A1) and the Vitamin D receptor gene (VDR). This analysis was conducted in the context of dietary Vitamin D, and background methyl donor related biochemistry, with adjustment for several dietary and lifestyle variables. Percentage methylation at CpG sites was assessed in peripheral blood cells using methylation sensitive and dependent enzymes and qPCR. Standard analytical techniques were used to determine plasma 25(OH)D and homocysteine, and serum folate and B12, with the relationship to methylation status assessed using multi-variable regression analysis. CYP2R1 and VDR methylation were found to be independent predictors of plasma 25(OH)D, when adjusted for Vitamin D intake and other lifestyle variables. CYP24A1 was related to plasma 25(OH)D directly, but not in the context of Vitamin D intake. Methyl-group donor biochemistry was associated with the methylation status of some genes, but did not alter the relationship between methylation and plasma 25(OH)D. Modulation of methylation status of CYP2R1, CYP24A1 and VDR in response to plasma 25(OH)D may be part of feedback loops involved in maintaining Vitamin D homeostasis, and may explain a portion of the variance in plasma 25(OH)D levels in response to intake and sun exposure. Methyl-group donor biochemistry, while a potential independent modulator, did not alter this effect.

DOI 10.1016/j.jnim.2016.04.010
Citations Scopus - 1
Co-authors Katrina King, Patrice Jones, Emma Beckett, John Furst, Martin Veysey, Zoe Yates
2016 Mingay E, Veysey M, Lucock M, Niblett S, King K, Patterson A, Garg M, 'Sex-dependent association between omega-3 index and body weight status in older Australians', Journal of Nutrition and Intermediary Metabolism, 5 70-77 (2016) [C1]

© 2016 The Authors Background/objectives Restricting energy intake for weight management in older adults has potential to adversely affect nutritional status and result in impair... [more]

© 2016 The Authors Background/objectives Restricting energy intake for weight management in older adults has potential to adversely affect nutritional status and result in impairment of an already compromised immune system. Investigation of alternative strategies to combat adiposity and sustain lean muscle mass in older adults are warranted to minimise the risk of developing chronic diseases. Long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may play an important role through their impact on increased fat oxidation and reduced inflammation. This study aimed to examine the association between erythrocyte membrane LCn-3PUFA and anthropometric measures in an older population. Subjects/methods A cross-sectional sample of older adults (n¿=¿620; age 65¿95 years; 56.3% females) from the Retirement Health and Lifestyle Study (RHLS) was analysed. Anthropometric measurements, including height, weight, body mass index (BMI), waist (WC) and hip circumference (HC) were taken. The fatty acid composition of erythrocyte membranes was analysed via gas chromatography (GC) to determine the omega-3 index (%EPA plus %DHA). Results An inverse association was detected between the omega-3 index and anthropometric measures, BMI (r¿=¿-0.076, p=0.06), WC (r¿=¿-0.118, p¿ < ¿0.01) and waist-to-hip ratio (WHR; r¿=¿-0.149, p¿ < ¿0.001). Stratification of data by sex (females, n¿=¿349; males, n¿=¿271) indicated that these associations were sex-specific. Females displayed an inverse association between the omega-3 index and BMI (r¿=¿-0.146, p¿ < ¿0.01) and WC (r¿=¿-0.125, p¿ < ¿0.05). In contrast, no significant association between the omega-3 index and anthropometric measures was detected in males. After correcting for the potentially confounding effects of age, household income, fish oil supplement status, daily dietary energy intake and total physical activity times, the omega-3 index was inversely associated with BMI and WC in females but not males. Conclusions Omega-3 status was associated with weight status, particularly in older women but not in men. These results suggest the need for sex-based intervention trials to examine the role of dietary intake and/or supplementation of LCn-3PUFA in weight management of older adults.

DOI 10.1016/j.jnim.2016.04.001
Co-authors Martin Veysey, Amanda Patterson, Katrina King, Manohar Garg
2016 Rose M, Veysey M, Lucock M, Niblett S, King K, Baines S, Garg ML, 'Association between erythrocyte omega-3 polyunsaturated fatty acid levels and fatty liver index in older people is sex dependent', Journal of Nutrition and Intermediary Metabolism, 5 78-85 (2016) [C1]

© 2016 The Authors Background/Objectives Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in older people but currently no specific drugs are available for its treat... [more]

© 2016 The Authors Background/Objectives Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in older people but currently no specific drugs are available for its treatment. Omega-3 polyunsaturated fatty acids (n-3PUFA), known for their lipid-lowering, anti-inflammatory and anti-hypertensive properties, may have therapeutic potential for the management of NAFLD. The aim of this study was to determine whether n-3PUFA levels are associated with the prevalence of NAFLD in older adults. Methods A cross-sectional sample of older adults aged 65¿95 years (n¿=¿620) from the Retirement Health and Lifestyle Study (RHLS) was analysed. Fatty Liver Index (FLI) scores, used as an indicator of NAFLD risk, were calculated using a validated a lgorithm that incorporates body mass index, waist circumference, plasma triglycerides and ¿-glutamyl transferase. Omega-3 index scores (O3I, %eicosapentaenoic acid plus %docosahexaenoic acid) were determined by analysing the fatty acid composition of erythrocyte membranes by gas chromatography. Results Following application of exclusion criteria, 475 participants were included in the analysis (age 77.9¿±¿7.0 years; 60.4% females). Of these, 216 participants had FLI scores (=60) suggestive of NAFLD (age 77.0¿±¿6.6 years; 49.1% females). O3I was significantly lower in participants with NAFLD compared to those without NAFLD (p¿ < ¿0.01). A significant inverse relationship was found between O3I and FLI (r¿=¿-0.165; p¿ < ¿0.001). This relationship was gender specific with women, but not men, showing a significant association (r¿=¿-0.206; p¿ < ¿0.001). Conclusions The current study demonstrated a sex-dependent inverse relationship between erythrocyte n-3PUFA concentrations and NAFLD in older adults. The finding supports the proposal for sex-stratified n-3PUFA intervention trials in this high-risk age group.

DOI 10.1016/j.jnim.2016.04.007
Co-authors Surinder Baines, Martin Veysey, Manohar Garg, Katrina King
2016 Olliver M, Veysey M, Lucock M, Niblett S, King K, MacDonald-Wicks L, Garg ML, 'Erythrocyte omega-3 polyunsaturated fatty acid levels are associated with biomarkers of inflammation in older Australians', Journal of Nutrition and Intermediary Metabolism, 5 61-69 (2016) [C1]

© 2016 The Authors Background Elevated levels of pro-inflammatory mediators heighten the risk of developing or aggravating a spectrum of chronic diseases and are a strong predict... [more]

© 2016 The Authors Background Elevated levels of pro-inflammatory mediators heighten the risk of developing or aggravating a spectrum of chronic diseases and are a strong predictor of mortality in elderly cohorts. Omega-3 polyunsaturated fatty acids (n-3PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are known to possess anti-inflammatory properties. However, the relationship between erythrocyte membrane n-3PUFA and inflammation biomarkers has not been well established. Objective This study aimed to determine if n-3PUFA status, together with the omega-3 index (O3I, erythrocyte membrane % EPA plus DHA), is associated with pro-inflammatory mediators in older Australians. Methods The study was a cross-sectional analysis of randomly selected older men and women aged =65 years (n¿=¿620) recruited from the Central Coast of NSW, Australia. Fasted blood samples were analysed for C-reactive protein (CRP), fibrinogen and full blood count using standardised laboratory methods. The fatty acid composition of erythrocyte membranes was analysed via gas chromatography to determine n-3PUFA levels. The relationships between n-3PUFA and inflammatory mediators were evaluated in multivariate regression models after adjusting for known inflammatory confounders. Results After excluding participants who had an inflammatory disease, CRP levels > 10¿mg/L, or who were taking anti-inflammatory medications or n-3PUFA supplements, 126 participants (age 77.6¿±¿7.3 years; females, 46%) were included in the analysis. After multivariate adjustments, O3I was inversely associated with CRP (ß¿=¿-0.209, p¿ < ¿0.05) and monocyte cell counts (ß¿=¿-0.205, p¿ < ¿0.05), and total n-3PUFA was inversely related to WBC (ß¿=¿-0.238, p¿ < ¿0.05), neutrophils (ß¿=¿-0.212, p¿ < ¿0.05) and monocytes (ß¿=¿-0.246, p¿ < ¿0.05). However no association between fibrinogen and O3I or total n-3PUFA was detected. Conclusions This study demonstrated a negative association between O3I and biomarkers of inflammation in an older population. The findings support a potential role for n-3PUFA supplementation in the management of inflammatory diseases.

DOI 10.1016/j.jnim.2016.03.002
Co-authors Katrina King, Martin Veysey, Lesley Wicks, Manohar Garg
2016 Ferguson JJA, Veysey M, Lucock M, Niblett S, King K, MacDonald-Wicks L, Garg ML, 'Association between omega-3 index and blood lipids in older Australians', Journal of Nutritional Biochemistry, 27 233-240 (2016) [C1]

© 2015 Elsevier Inc. Management of hyperlipidaemia remains a cornerstone therapy for the prevention of cardiovascular disease (CVD). Dietary supplementation with n-3 polyunsatura... [more]

© 2015 Elsevier Inc. Management of hyperlipidaemia remains a cornerstone therapy for the prevention of cardiovascular disease (CVD). Dietary supplementation with n-3 polyunsaturated fatty acid (PUFA) has been shown to modulate blood lipid profiles and reduce the risk of developing CVD. However, studies relating objective measures of long-term dietary n-3 PUFA intake and circulating lipid levels in older adults are limited. Thus, we aimed to determine whether there is an association between erythrocyte n-3 PUFA status (omega-3 index, O3I) and blood lipid profiles in older adults. A sample of adults aged 65-95 years who participated in the Retirement Health and Lifestyle Study was evaluated. Outcome measures included O3I (% eicosapentaenoic acid+% docosahexaenoic acid) and fasting blood lipid profiles [total cholesterol (TC), low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol and triglyceride (TG)]. Two hundred and seventy-six subjects were included in the analyses. The mean±SD age was 77.6±7.4 years, and 40.9% were males. O3I was significantly higher in females compared to males. O3I was inversely associated with plasma TG (P < .001) and TC/HDL-cholesterol ratio (P < .05), and positively associated with HDL-cholesterol (P < .05), in all subjects. Associations between O3I and TG were evident in both females (r=-0.250, P < .01) and males (r=-0.225, P < .05). In females only, the odds of being hypertriglyceridaemic were highest in those with lowest O3I (P=006). Trends for hypercholesterolaemia and elevated LDL risk were converse between males and females. Long-term n-3 PUFA status is associated with blood lipid profiles in older Australians. Our findings support the development and implementation of age-specific dietary strategies to reduce the risk of CVD via improving the O3I.

DOI 10.1016/j.jnutbio.2015.09.010
Citations Scopus - 3Web of Science - 1
Co-authors Katrina King, Martin Veysey, Manohar Garg, Lesley Wicks
2015 Lucock M, Jones P, Martin C, Beckett E, Yates Z, Furst J, Veysey M, 'Vitamin D: Beyond Metabolism', Journal of Evidence-Based Complementary and Alternative Medicine, 20 310-322 (2015) [C1]

© 2015, The Author(s) 2015. Interest in vitamin D and the VDR gene is increasing as putative roles in human health and evolutionary processes are explored. This review looks beyo... [more]

© 2015, The Author(s) 2015. Interest in vitamin D and the VDR gene is increasing as putative roles in human health and evolutionary processes are explored. This review looks beyond the classic biochemistry that links vitamin D to calcium homeostasis; it explores how vitamin D interacts with light in a broader perspective than simple skin photosynthesis. It examines how the vitamin influences circadian rhythm, and how it may have helped drive the evolution of skin pigmentation. To this end, the nutrient¿nutrient relationship with folate is also explored. The VDR gene is additionally examined as a factor in the evolutionary selection of skin depigmentation at higher latitudes to allow vitamin D synthesis. Evidence is given to show that VDR polymorphisms exhibit a latitudinal gradient in allele prevalence consistent with such a paradigm. Overall, the review examines new evo-devo ideas that link light-sensitive vitamins to human health/phenotype, both within and across the lifecycle.

DOI 10.1177/2156587215580491
Citations Scopus - 3
Co-authors Martin Veysey, Zoe Yates, Patrice Jones, John Furst, Emma Beckett
2015 Lucock M, Yates Z, Martin C, Choi JH, Beckett E, Boyd L, et al., 'Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence', BBA Clinical, 3 107-112 (2015) [C1]

© 2015 The Authors. Purpose: The aim of this study is to explore whether a methylation diet influences risk for adenomatous polyps (AP) either independently, or interactively wit... [more]

© 2015 The Authors. Purpose: The aim of this study is to explore whether a methylation diet influences risk for adenomatous polyps (AP) either independently, or interactively with one-carbon metabolism-dependent gene variants, and whether such a diet modifies blood homocysteine, a biochemical phenotype closely related to the phenomenon of methylation. Methods: 249 subjects were examined using selective fluorescence, PCR and food frequency questionnaire to determine homocysteine, nine methylation-related gene polymorphisms, dietary methionine, 5-methyltetrahydrofolate, vitamins B6 and B12. Results: 1). Both dietary methionine and 5-methyltetrahydrofolate intake are significantly associated with plasma homocysteine. 2). Dietary methionine is related to AP risk in 2R3R-TS wildtype subjects, while dietary B12 is similarly related to this phenotype in individuals heterozygous for C1420T-SHMT, A2756G-MS and 844ins68-CBS, and in those recessive for 2R3R-TS. 3). Dietary methionine has a marginal influence on plasma homocysteine level in C1420T-SHMT heterozygotes, while B6 exhibits the same effect on homocysteine in C776G-TCN2 homozygote recessive subjects. Natural 5-methyltetrahydrofolate intake is interesting: Wildtype A1298C-MTHFR, heterozygote C677T-MTHFR, wildtype A2756G-MS and recessive A66G-MSR individuals all show a significant reciprocal association with homocysteine. 4). Stepwise regression of all genotypes to predict risk for AP indicated A2756G-MS and A66G-MSR to be most relevant (p= 0.0176 and 0.0408 respectively). Results were corrected for age and gender. Conclusion: A methylation diet influences methyl group synthesis in the regulation of blood homocysteine level, and is modulated by genetic interactions. Methylation-related nutrients also interact with key genes to modify risk of AP, a precursor of colorectal cancer. Independent of diet, two methylation-related genes (A2756G-MS and A66G-MSR) were directly associated with AP occurrence.

DOI 10.1016/j.bbacli.2014.11.005
Citations Scopus - 6Web of Science - 3
Co-authors Zoe Yates, Emma Beckett, Paul Roach, Martin Veysey
2015 Choi J-H, Yates Z, Martin C, Boyd L, Ng X, Skinner V, et al., 'Gene-Nutrient Interaction between Folate and Dihydrofolate Reductase in Risk for Adenomatous Polyp Occurrence: A Preliminary Report', JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 61 455-459 (2015) [C1]
Co-authors Zoe Yates, Martin Veysey
2015 Choi JH, Yates Z, Martin C, Boyd L, Ng X, Skinner V, et al., 'Genetic variation in glutamate carboxypeptidase II and interaction with dietary natural vitamin C may predict risk for adenomatous polyp occurrence', Asian Pacific Journal of Cancer Prevention, 16 4383-4386 (2015) [C1]

Background: The C1561T variant of the glutamate carboxypeptidase II (GCPII) gene is critical for natural methylfolylpolyglutamte (methylfolate) absorption, and has been associated... [more]

Background: The C1561T variant of the glutamate carboxypeptidase II (GCPII) gene is critical for natural methylfolylpolyglutamte (methylfolate) absorption, and has been associated with perturbations in folate metabolism and disease susceptibility. However, little is known on C1561T-GCPII as a risk factor for colorectal cancer. Therefore, this study examined whether C1561T-GCPII influences folate metabolism and adenomatous polyp occurrence. Materials and Methods: 164 controls and 38 adenomatous polyp cases were analysed to determine blood folate and plasma homocysteine (Hcy) level, dietary intake of natural methylfolate, synthetic pteroylglutamic acid (PteGlu), vitamin C and C1561T-GCPII genotype. Results: In controls and cases, 7.3 and 18.4 percent of subjects respectively, were found to have the CT genotype, increasing the risk for adenomatous polyp occurrence 2.86 times (95% CI:1.37-8.0, p=0.035). Total dietary folate, methylfolate and PteGlu intake and the level of erythrocyte folate and plasma Hcy did not predict the occurrence of an adenomatous polyp. However, dietary natural vitamin C intake was associated with adenomatous polyp risk within C1561T-GCPII CT genotype subjects (p=0.037). Conclusions: The findings suggest that C1561T-GCPII variation may be associated with risk for adenomatous polyp, and vitamin C may modify risk by interacting with the variant gene, its expression product and/or folate substrates.

DOI 10.7314/APJCP.2015.16.10.4383
Co-authors Zoe Yates, Martin Veysey
2015 Beckett EL, Martin C, Duesing K, Jones P, Furst J, Yates Z, et al., 'Vitamin D receptor genotype modulates the correlation between vitamin D and circulating levels of let-7a/b and vitamin D intake in an elderly cohort', Journal of Nutrigenetics and Nutrigenomics, 7 264-273 (2015) [C1]
DOI 10.1159/000381676
Citations Scopus - 9Web of Science - 7
Co-authors Emma Beckett, John Furst, Patrice Jones, Martin Veysey, Zoe Yates
2015 Beckett EL, Martin C, Choi JH, King K, Niblett S, Boyd L, et al., 'Folate status, folate-related genes and serum miR-21 expression: Implications for miR-21 as a biomarker', BBA Clinical, 4 45-51 (2015) [C1]

© 2015. Background: Free circulating microRNA (miRNA) in serum may be valuable biomarkers for disease diagnosis and prognosis. miR-21, the archetypal oncogenic miRNA, has been pr... [more]

© 2015. Background: Free circulating microRNA (miRNA) in serum may be valuable biomarkers for disease diagnosis and prognosis. miR-21, the archetypal oncogenic miRNA, has been proposed as a biomarker for colorectal cancer and its benign precursor, adenomatous polyps. However, it is now becoming clear that circulating miRNA profiles may be sensitive to lifestyle and environmental influences. Dietary components involved in one-carbon metabolism are particularly well placed to modulate miRNA expression through an influence on DNA methylation pathways. Methods: We investigated the role of methyl group donors (folate, B12, cysteine, homocysteine), polymorphisms of the enzymes of one-carbon metabolism, and serum miR-21 expression in a primary case-control cohort (colonoscopy confirmed adenomatous colon polyps vs controls; n. =. 253) and a secondary cross-sectional cohort (over 65s; n. =. 649). The relationships between these parameters and serum miR-21 levels were assessed, stratified by gender. Conclusions: Serum miR-21 expression was related to occurrence of adenomatous polyps in females, but not males. Folate levels and MTHFR-C677T genotype was associated with miR-21 expression in both genders. Additionally, DHFR-19 del and MSR-A66G were associated with miR-21 expression in females and males, respectively. Stimulation with excess folate increased expression of miR-21 in colon cancer cell lines. General significance: This study demonstrates that serum miR-21 expression correlates with folate status and related genetic status. This may have consequences for the proposed use of miR-21 as a colorectal cancer biomarker.

DOI 10.1016/j.bbacli.2015.06.006
Citations Scopus - 10Web of Science - 8
Co-authors Emma Beckett, Martin Veysey, Zoe Yates, Katrina King
2015 Beckett EL, Le Gras KC, Veysey M, Boyd L, Ng X, Yates Z, et al., 'Vitamin D receptor polymorphism Fok1 alters risk for adenomatous polyps in Australian males', Journal of Nutrigenetics and Nutrigenomics, 8 2-2 (2015)
Co-authors Emma Beckett, Zoe Yates, Martin Veysey
2014 Choi JH, Yates Z, Veysey M, Heo YR, Lucock M, 'Contemporary issues surrounding folic acid fortification initiatives', Preventive Nutrition and Food Science, 19 247-260 (2014) [C1]

Copyright © 2014 by The Korean Society of Food Science and Nutrition. All rights Reserved. The impact of folate on health and disease, particularly pregnancy complications and co... [more]

Copyright © 2014 by The Korean Society of Food Science and Nutrition. All rights Reserved. The impact of folate on health and disease, particularly pregnancy complications and congenital malformations, has been extensively studied. Mandatory folic acid fortification therefore has been implemented in multiple countries, resulting in a reduction in the occurrence of neural tube defects. However, emerging evidence suggests increased folate intake may also be associated with unexpected adverse effects. This literature review focuses on contemporary issues of concern, and possible underlying mechanisms as well as giving consideration the future direction of mandatory folic acid fortification. Folate fortification has been associated with the presence of unmetabolized folic acid (PteGlu) in blood, masking of vitamin B 12 deficiency, increased dosage for anti-cancer medication, photo-catalysis of PteGlu leading to potential genotoxicity, and a role in the pathoaetiology of colorectal cancer. Increased folate intake has also been associated with twin birth and insulin resistance in offspring, and altered epigenetic mechanisms of inheritance. Although limited data exists to elucidate potential mechanisms underlying these issues, elevated blood folate level due to the excess use of PteGlu without consideration of an individual's specific phenotypic traits (e.g. genetic background and undiagnosed disease) may be relevant. Additionally, the accumulation of unmetabolized PteGlu may lead to inhibition of dihydrofolate reductase and other enzymes. Concerns notwithstanding, folic acid fortification has achieved enormous advances in public health. It therefore seems prudent to target and carefully monitor high risk groups, and to conduct well focused further research to better understand and to minimize any risk of mandatory folic acid fortification.

DOI 10.3746/pnf.2014.19.4.247
Citations Scopus - 27
Co-authors Martin Veysey, Zoe Yates
2014 Martin C, Yates Z, Veysey M, Lucock MD, 'Vitamin D Receptor Genetics and Calcium Intake in an Elderly Australian Cohort with Osteoporosis', Journal of Nutrigenetics and Nutrigenomics, 7 35-35 (2014)
Co-authors Martin Veysey, Zoe Yates
2014 Beckett EL, Veysey M, Ng X, Boyd L, Tang S, Yates Z, et al., 'Bitter taste phenotype better predicts folate status than tas2r38 bitter receptor genotype alone in a colonoscopy cohort', Journal of Nutrition & Intermediary Metabolism, 1 13-14 (2014)
DOI 10.1016/j.jnim.2014.10.039
Co-authors Emma Beckett
2014 Yates Z, Lucock MD, Beckett E, Veysey M, 'B-vitamins and cognition - food for thought', NEUROLOGY, (2014)
Co-authors Zoe Yates, Emma Beckett, Martin Veysey
2014 Beckett E, Martin C, Duesing K, Yates Z, Veysey M, Lucock MD, 'Vitamin D Receptor Genotype Modulates the Correlation Between Circulating Levels of miR-7a/b and Vitamin D Intake in an Elderly Cohort.', Journal of Nutrigenetics and Nutrigenomics, 7 10-10 (2014)
Co-authors Emma Beckett, Martin Veysey, Zoe Yates
2014 Drever J, Veysey M, Lucock MD, Niblett S, King K, MacDonald-Wicks L, Garg ML, 'Association between n-3 PUFA and blood lipid profile in older Australians.', Journal of Nutrition & Intermediary Metabolism, 1 31-31 (2014)
Co-authors Martin Veysey, Katrina King, Lesley Wicks, Manohar Garg
2014 Abbott K, Veysey M, Lucock MD, Niblett S, King K, MacDonald-Wicks L, Garg ML, 'N-3 pufa status is inversely associated with type 2 diabetes mellitus in older Australians.', Journal of Nutrition & Intermediary Metabolism, 1 31-31 (2014)
Co-authors Lesley Wicks, Manohar Garg, Martin Veysey, Katrina King
2014 Mingay E, Veysey M, Lucock MD, Niblett S, King K, Patterson A, Garg ML, 'Erythrocyte long chain n-3 pufa level is a predictor of body weight status in older Australians.', Journal of Nutrition & Intermediary Metabolism, 1 8-9 (2014)
Co-authors Amanda Patterson, Katrina King, Martin Veysey, Manohar Garg
2014 Olliver M, Veysey M, Lucock MD, Niblett S, King K, MacDonald-Wicks L, Garg ML, 'Erythrocyte n-3pufa levels predict inflammatory status in older Australians.', Journal of Nutrition & Intermediary Metabolism, 1 10-10 (2014)
Co-authors Martin Veysey, Manohar Garg, Lesley Wicks, Katrina King
2014 Rose M, Veysey M, Lucock MD, Niblett S, King K, Baines S, Garg ML, 'N-3 pufa status predicts non-alcoholic fatty liver disease (NAFLD) in older Australians.', Journal of Nutrition & Intermediary Metabolism, 1 9-9 (2014)
Co-authors Martin Veysey, Surinder Baines, Katrina King, Manohar Garg
2014 Lucock MD, Martin CE, Yates ZR, Veysey M, 'Diet and Our Genetic Legacy in the Recent Anthropocene: A Darwinian Perspective to Nutritional Health', Journal of Evidence-Based Complementary and Alternative Medicine, 19 68-83 (2014) [C1]

Nutrient-gene research tends to focus on human disease, although such interactions are often a by-product of our evolutionary heritage. This review explores health in this context... [more]

Nutrient-gene research tends to focus on human disease, although such interactions are often a by-product of our evolutionary heritage. This review explores health in this context, reframing genetic variation/epigenetic phenomena linked to diet in the framework of our recent evolutionary past. This "Darwinian/evolutionary medicine" approach examines how diet helped us evolve among primates and to adapt (or fail to adapt) our metabolome to specific environmental conditions leading to major diseases of civilization. This review presents updated evidence from a diet-gene perspective, portraying discord that exists with respect to health and our overall nutritional, cultural, and activity patterns. While Darwinian theory goes beyond nutritional considerations, a significant component within this concept does relate to nutrition and the mismatch between genes, modern diet, obesogenic lifestyle, and health outcomes. The review argues that nutritional sciences should expand knowledge on the evolutionary connection between food and disease, assimilating it into clinical training with greater prominence. © The Author(s) 2013.

DOI 10.1177/2156587213503345
Citations Scopus - 10
Co-authors Martin Veysey, Zoe Yates
2014 Lucock M, Yates Z, Martin C, Choi JH, Boyd L, Tang S, et al., 'Vitamin D, folate, and potential early lifecycle environmental origin of significant adult phenotypes.', Evolution, Medicine, and Public Health, 2014 69-91 (2014) [C1]
DOI 10.1093/emph/eou013
Co-authors John Furst, Paul Roach, Martin Veysey, Zoe Yates
2014 Martin CE, Veysey M, Yates Z, Lucock MD, 'Vitamin D: Genetics, Environment & Health', Food and Nutritional Disorders, 3 1-19 (2014) [C1]
DOI 10.4172/2324-9323.1000155
Co-authors Zoe Yates, Martin Veysey
2013 Lucock M, Leeming R, 'Autism, seasonality and the environmental perturbation of epigenome related vitamin levels', Medical Hypotheses, 80 750-755 (2013) [C1]
DOI 10.1016/j.mehy.2013.03.003
Citations Scopus - 4Web of Science - 2
2013 Lucock MD, Martin C, Boyd L, Naumovski N, Roach P, Yates Z, Veysey M, 'Response to 'calcium, phosphate and the risk of cardiovascular events and all-cause mortality in a population with stable coronary heart disease'', HEART, 99 349-350 (2013) [C3]
DOI 10.1136/heartjnl-2012-302480
Co-authors Martin Veysey, Paul Roach, Zoe Yates
2013 Lucock M, Yates Z, Boyd L, Naylor C, Choi J, Ng X, et al., 'Vitamin C-related nutrient-nutrient and nutrient-gene interactions that modify folate status', European Journal of Nutrition, 52 569-582 (2013) [C1]
DOI 10.1007/s00394-012-0359-8
Citations Scopus - 14Web of Science - 9
Co-authors Martin Veysey, Zoe Yates, Paul Roach
2013 Lucock M, Yates Z, Martin C, Choi J, Boyd L, Tang S, et al., 'Hydrogen sulphide-related thiol metabolism and nutrigenetics in relation to hypertension in an elderly population', Genes & Nutrition, 8 221-229 (2013) [C1]
DOI 10.1007/s12263-012-0317-3
Citations Scopus - 5Web of Science - 6
Co-authors Zoe Yates, Paul Roach, Martin Veysey
2012 Lucock MD, 'Dietary supplements and altered mortality: A conflict of evolutionary medicine', Archives of Internal Medicine, 172 448-449 (2012) [C3]
Citations Scopus - 2Web of Science - 1
2012 Lucock MD, Glanville T, Yates ZR, Walker J, Furst JE, Simpson N, 'Solar cycle predicts folate-sensitive neonatal genotypes at discrete phases of the first trimester of pregnancy: A novel folate-related human embryo loss hypothesis', Medical Hypotheses, 79 210-215 (2012) [C1]
Citations Scopus - 8Web of Science - 6
Co-authors Zoe Yates, John Furst
2011 Lucock MD, Ng X, Boyd L, Skinner VM, Wai R, Tang S, et al., 'TAS2R38 bitter taste genetics, dietary vitamin C, and both natural and synthetic dietary folic acid predict folate status, a key micronutrient in the pathoaetiology of adenomatous polyps', Food & Function, 2 457-465 (2011) [C1]
DOI 10.1039/c1fo10054h
Citations Scopus - 15Web of Science - 12
Co-authors Zoe Yates, Martin Veysey, Paul Roach
2011 Lucock M, 'Folic acid: Beyond metabolism', Journal of Evidence-Based Complementary and Alternative Medicine, 16 102-113 (2011) [C3]

Mandatory and discretionary fortification with folic acid is eliminating deficiency of this vitamin. Blood levels of the vitamin have never been higher, with hematologic folate va... [more]

Mandatory and discretionary fortification with folic acid is eliminating deficiency of this vitamin. Blood levels of the vitamin have never been higher, with hematologic folate values commonly exceeding the upper range of calibration. The synthetic analog (pteroylmonoglutamic acid) prevents neural tube defects and lowers homocysteine, both positive attributes, yet negative correlates of pteroylmonoglutamic acid are increasingly reported. These involve increased risk for common cancers (ie, colon, breast, prostate) and antimetabolite effects on natural killer cells and at dihydrofolate reductase, a critical gatekeeper enzyme. This review, however, takes a different, human ecological perspective, examining novel folate-related phenomena distinct from the classic metabolic role of the vitamin in maintaining health and well-being. An argument is developed that at molecular, cellular, and organism levels, folate is crucial to some important events that link light to life. © The Author(s) 2011.

Citations Scopus - 3
2011 Lucock MD, 'Folic acid: Beyond metabolism', Journal of Evidence-Based Complementary and Alternative Medicine, 16 102-113 (2011) [C1]
DOI 10.1177/1533210110392950
Citations Scopus - 6
2010 Lucock MD, Glanville T, Ovadia L, Yates ZR, Walker J, Simpson N, 'Photoperiod at conception predicts C677T-MTHFR genotype: A novel gene-environment interaction', American Journal of Human Biology, 22 484-489 (2010) [C1]
DOI 10.1002/ajhb.21022
Citations Scopus - 16Web of Science - 10
Co-authors Zoe Yates
2010 Naumovski N, Veysey M, Ng X, Boyd L, Dufficy L, Blades BL, et al., 'The folic acid endophenotype and depression in an elderly population', Journal of Nutrition, Health and Aging, 14 829-833 (2010) [C1]
DOI 10.1007/s12603-010-0135-5
Citations Scopus - 5Web of Science - 5
Co-authors Zoe Yates, Paul Roach, Martin Veysey, Maureen Townley-Jones
2009 Ng X, Boyd L, Dufficy L, Naumovski N, Blades BL, Travers C, et al., 'Folate nutritional genetics and risk for hypertension in an elderly population sample', Journal of Nutrigenetics and Nutrigenomics, 2 1-8 (2009) [C1]
DOI 10.1159/000160079
Citations Scopus - 12Web of Science - 11
Co-authors Maureen Townley-Jones, Martin Veysey, Zoe Yates, Paul Roach
2009 Smith DR, Lucock MD, 'Should folate supplements be integrated with workplace nutrition programs?', Industrial Health, 47 449-451 (2009) [C3]
DOI 10.2486/indhealth.47.449
Citations Scopus - 2Web of Science - 1
2009 Leeming RJ, Lucock MD, 'Autism: Is there a folate connection?', Journal of Inherited Metabolic Disease, 32 400-402 (2009) [C2]
DOI 10.1007/s10545-009-1093-0
Citations Scopus - 8Web of Science - 8
2009 Sohn K-J, Jang H, Campan M, Weisenberger DJ, Dickhout J, Wang Y-C, et al., 'The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: A possible molecular basis for the site-specific cancer risk modification', International Journal of Cancer, 124 1999-2005 (2009) [C1]
DOI 10.1002/ijc.24003
Citations Scopus - 54Web of Science - 52
Co-authors Zoe Yates
2009 Lucock MD, Yates ZR, 'Folic acid fortification: A double-edged sword', Current Opinion in Clinical Nutrition & Metabolic Care, 12 555-564 (2009) [C1]
DOI 10.1097/mco.0b013e32833192bc
Citations Scopus - 63Web of Science - 48
Co-authors Zoe Yates
2008 Ng X, Lucock M, Veysey M, 'Physicochemical effect of pH and antioxidants on mono- and triglutamate forms of 5-methyltetrahydrofolate, and evaluation of vitamin stability in human gastric juice: Implications for folate bioavailability (vol 106, pg 200, 2008)', FOOD CHEMISTRY, 110 1000-1000 (2008) [C3]
DOI 10.1016/j.foodchem.2008.04.001
Co-authors Martin Veysey
2008 Ng X, Lucock MD, Veysey MJ, 'Physicochemical effect of pH and antioxidants on mono- and triglutamate forms of 5-methyltetrahydrofolate, and evaluation of vitamin stability in human gastric juice: Implications for folate bioavailability', Food Chemistry, 106 200-210 (2008) [C1]
DOI 10.1016/j.foodchem.2007.05.057
Citations Scopus - 13Web of Science - 12
Co-authors Martin Veysey
2007 Adams MC, Lucock MD, Stuart JE, Fardell S, Baker K, Ng X, 'Preliminary evidence for involvement of the folate gene polymorphism 19 bp deletion-DHFR in occurrence of autism', Neuroscience Letters, 422 24-29 (2007) [C1]
DOI 10.1016/j.neulet.2007.05.025
Citations Scopus - 37Web of Science - 37
Co-authors John Stuart
2007 Lucock MD, Yates ZR, Ng X, Veysey MJ, Blades BL, Travers C, et al., 'Preliminary evidence for genetic selection of 677T-MTHFR by natural annual cycle of folate abundance', Journal of Nutrigenetics and Nutrigenomics, 1 24-29 (2007) [C1]
DOI 10.1159/000109872
Citations Scopus - 10Web of Science - 8
Co-authors Martin Veysey, Zoe Yates, Paul Roach
2006 Dufficy L, Naumovski N, Ng X, Blades BL, Yates ZR, Travers C, et al., 'G80A reduced folate carrier SNP influences the absorption and cellular translocation of dietary folate and its association with blood pressure in an elderly population', Life Sciences, 79 957-966 (2006) [C1]
DOI 10.1016/j.lfs.2006.05.009
Citations Scopus - 22Web of Science - 21
Co-authors Zoe Yates, Martin Veysey, Paul Roach
2006 Glanville T, Yates ZR, Ovadia L, Walker JJ, Lucock MD, Simpson NAB, 'Fetal folate C677T methylenetetrahydrofolate reductase gene polymorphism and low birth weight', Journal of Obstetrics and Gynaecology, 26 11-14 (2006) [C1]
DOI 10.1080/01443610500363865
Citations Scopus - 11
Co-authors Zoe Yates
2006 Lucock MD, Yates ZR, 'Synergy between 677 TT MTHFR genotype and related folate SNPs regulates homocysteine level', Nutrition Research, 26 180-185 (2006) [C1]
DOI 10.1016/j.nutres.2006.01.001
Citations Scopus - 7Web of Science - 6
Co-authors Zoe Yates
2006 Lucock MD, 'Synergy of genes and nutrients: The case of homocysteine', Current Opinion in Clinical Nutrition and Metabolic Care, 9 748-756 (2006) [C1]
DOI 10.1097/01.mco.0000247468.18790.1e
Citations Scopus - 24Web of Science - 17
2005 Lucock MD, Ng X, Veysey MJ, Yates ZR, 'Folic acid: An essential nutrient with added health benefits', Biologist, 52 21-27 (2005) [C1]
Citations Scopus - 2
Co-authors Zoe Yates, Martin Veysey
2005 Lucock MD, Roach PD, 'The antifolate activity of tea catechins (letter)', Cancer Research, 65 8573-8573 (2005) [C3]
Citations Scopus - 4Web of Science - 3
Co-authors Paul Roach
2005 Lucock MD, Yates Z, 'Folic acid - vitamin and panacea or genetic time bomb?', Nature Reviews Genetics, 6 235-240 (2005) [C1]
DOI 10.1038/nrg1558
Citations Scopus - 99Web of Science - 85
Co-authors Zoe Yates
2005 Yates ZR, Lucock MD, 'G80A reduced folate carrier SNP modulates cellular uptake of folate and affords protection against thrombosis via a non homocysteine related mechanism', Life Sciences, 77 2735-2742 (2005) [C1]
DOI 10.1016/j.lfs.2005.02.029
Citations Scopus - 36Web of Science - 37
Co-authors Zoe Yates
2005 Lucock MD, Yates ZR, 'Human genetic selection by folates', Nature Reviews Genetics, 6 online (2005) [C3]
Co-authors Zoe Yates
2004 Sohn K-J, Croxford R, Yates ZR, Lucock MD, Kim Y-I, 'Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate', Journal of the National Cancer Institute, 96 134-144 (2004) [C1]
DOI 10.1093/jnci/djh
Citations Scopus - 176Web of Science - 164
Co-authors Zoe Yates
2004 Sohn K-J, Smirnakis F, Moskovitz DN, Novakovic P, Yates ZR, Lucock MD, et al., 'Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate', GUT, 53 1825-1831 (2004) [C1]
DOI 10.1136/gut.2004.042713
Citations Scopus - 21Web of Science - 20
Co-authors Zoe Yates
2004 Blackburn A, Bibby MC, Lucock MD, Nicolaou A, 'Temporal evaluation of methionine synthase and related metabolites in the MAC15A mouse adenocarcinoma animal model', International Journal of Cancer, 112 577-584 (2004) [C1]
DOI 10.1002/ijc.20451
Citations Scopus - 3Web of Science - 2
2004 Lucock MD, 'Is folic acid the ultimate functional food component for disease prevention?', British Medical Journal, 328 211-214 (2004) [C1]
DOI 10.1136/bmj.328.7433.211
Citations Web of Science - 115
2004 Lucock M, 'Is folic acid the ultimate functional food component for disease prevention?', BMJ, 328 211-214 (2004)
DOI 10.1136/bmj.328.7433.211
Citations Scopus - 133
2004 Lucock MD, 'Is folic acid the ultimate functional food component for disease prevention?', BMJ USA, 4 127-130 (2004) [C1]
2003 Lucock MD, Yates ZR, Glanville T, Leeming R, Simpson N, Daskalakis I, 'A critical role for B-vitamin nutrition in human developmental and evolutionary biology', Nutrition Research, 23 1463-1475 (2003) [C1]
DOI 10.1016/S0271-5317(03)00156-8
Citations Scopus - 44Web of Science - 29
Co-authors Zoe Yates
2003 Yates Z, Lucock M, 'Interaction between common folate polymorphisms and B-vitamin nutritional status modulates homocysteine and risk for a thrombotic event', MOLECULAR GENETICS AND METABOLISM, 79 201-213 (2003) [C1]
DOI 10.1016/S1096-7192(03)00093-3
Citations Scopus - 16Web of Science - 15
Co-authors Zoe Yates
2002 Lucock M, Yates Z, 'Correspondence: Measurement of red blood cell methylfolate', Lancet, 360 (2002) [C3]
2002 Lucock M, Yates Z, 'Measurement of red blood cell methylfolate', LANCET, 360 1021-1022 (2002) [C1]
DOI 10.1016/S0140-6736(02)11105-6
Citations Scopus - 9Web of Science - 5
Co-authors Zoe Yates
2002 Yates Z, Lucock M, 'Methionine synthase, polymorphism A2756G is associated with susceptibility for thromboembolic events and altered B vitamin/thiol metabolism', HAEMATOLOGICA, 87 751-756 (2002) [C1]
Citations Scopus - 18Web of Science - 18
Co-authors Zoe Yates
2002 Lucock M, Yates Z, Hall K, Leeming R, Rylance G, MacDonald A, Green A, 'The impact of phenylketonuria on folate metabolism', MOLECULAR GENETICS AND METABOLISM, 76 305-312 (2002) [C1]
DOI 10.1016/S1096-7192(02)00113-0
Citations Scopus - 14Web of Science - 12
Co-authors Zoe Yates
2002 Lucock M, Yates Z, Hall K, Leeming R, Rylance G, MacDonald A, Green A, 'The impact of phenylketonuria on folate metabolism', Molecular Genetics and Metabolism, 1096-7206 (2002) [C1]
2002 Glanville T, Yates Z, Ovadia L, Walker JJ, Lucock MD, Simpson NAB, 'Folate gene Polymorphism and fetal growth restriction.', British Journal of Obstetrics and Gynaecology, 109 481-481 (2002)
Co-authors Zoe Yates
2001 Lucock M, Daskalakis I, Yates Z, 'C677T MTHFR genotypes show graded response to vitamin B-12 dependent regeneration of tetrahydrofolate, the main congener of all cellular folates', NUTRITION RESEARCH, 21 1357-1362 (2001) [C1]
DOI 10.1016/S0271-5317(01)00345-1
Citations Scopus - 2Web of Science - 1
Co-authors Zoe Yates
2001 Lucock M, Yates Z, Daskalakis I, 'C677T MTHFR genotypes show graded response to vitamin B12 dependent regeneration of tetrahydrofolate, the main congenor of all cellular folates', Nutrition Research, 0271-5317 (2001) [C1]
2001 Lucock M, Daskalakis I, Hinkins M, Yates Z, 'An examination of polymorphic genes and folate metabolism in mothers affected by a spina bifida pregnancy', MOLECULAR GENETICS AND METABOLISM, 73 322-332 (2001) [C1]
DOI 10.1006/mgme.2001.3205
Citations Scopus - 28Web of Science - 25
Co-authors Zoe Yates
2001 Lucock M, Daskalakis I, Hinkins M, Yates Z, 'An examination of polymorphic genes and folate metabolism in mothers affected by a spina bifida pregnancy', Molecular Genetics and Metabolism, 1096-7206 (2001) [C1]
2001 Lucock M, Yates Z, 'Update on folic acid and neural tube defects: 'Comment' article', Clinical Nutrition, 10 25-33 (2001) [C1]
Co-authors Zoe Yates
2001 Lucock MD, Yates Z, Cade A, '12 Channel coulometric electrochemical detection for the identification of polyglutamate homology amongst cellular folates.', PTERIDINES, 12 59-59 (2001)
Co-authors Zoe Yates
2001 Yates Z, Lucock MD, 'C677T MTHFR genotype is a risk factor for thromboembolism: comparison of T allele frequency and homocysteine level between female thromboembolic and non-thromboembolic vascular patients, NTD mothers and matched NTD controls.', PTERIDINES, 12 92-92 (2001)
Co-authors Zoe Yates
2001 Lucock MD, Yates Z, Cade A, 'Gastro-intestinal pH modulates facile interconvertion of native formylfolates during absorption.', PTERIDINES, 12 60-60 (2001)
Co-authors Zoe Yates
2000 Lucock M, Daskalakis I, 'New perspectives on folate status: a differential role for the vitamin in cardiovascular disease, birth defects and other conditions', BRITISH JOURNAL OF BIOMEDICAL SCIENCE, 57 254-260 (2000)
Citations Scopus - 25Web of Science - 16
2000 Lucock M, Daskalakis I, Briggs D, Yates Z, Levene M, 'Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: Influence of 677c -\ t methylenetetrahydrofolate reductase and 2756a -\ g methionine synthase genotypes', MOLECULAR GENETICS AND METABOLISM, 70 27-44 (2000) [C1]
DOI 10.1006/mgme.2000.2994
Citations Scopus - 43Web of Science - 39
Co-authors Zoe Yates
2000 Lucock M, 'Folic acid: Nutritional biochemistry, molecular biology, and role in disease processes', MOLECULAR GENETICS AND METABOLISM, 71 121-138 (2000)
DOI 10.1006/mgme.2000.3027
Citations Scopus - 468Web of Science - 414
1999 Lucock MD, Daskalakis I, Schorah CJ, Lumb CH, Oliver M, Devitt H, et al., 'Folate-homocysteine interrelations: Potential new markers of folate status', MOLECULAR GENETICS AND METABOLISM, 67 23-35 (1999)
DOI 10.1006/mgme.1999.2813
Citations Scopus - 22Web of Science - 23
1999 Lucock MD, 'Food fortification with folic acid', eBMJ, (1999)
1998 Schorah CJ, Devitt H, Lucock M, Dowell AC, 'The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study', EUROPEAN JOURNAL OF CLINICAL NUTRITION, 52 407-411 (1998)
DOI 10.1038/sj.ejcn.1600576
Citations Scopus - 71Web of Science - 57
1998 Lucock MD, Daskalakis I, Lumb CH, Schorah CJ, Levene MI, 'Impaired regeneration of monoglutamyl tetrahydrofolate leads to cellular folate depletion in mothers affected by a spina bifida pregnancy', MOLECULAR GENETICS AND METABOLISM, 65 18-30 (1998)
DOI 10.1006/mgme.1998.2738
Citations Scopus - 20Web of Science - 19
1998 Lucock MD, 'What is meant by folic acid and folate status.', BRITISH JOURNAL OF BIOMEDICAL SCIENCE, 55 54-54 (1998)
1997 Lucock MD, Wild J, Lumb CH, Oliver M, Kendall R, Daskalakis I, et al., 'Risk of neural tube defect-affected pregnancy is associated with a block in maternal one-carbon metabolism at the level of N-5-methyltetrahydrofolate:homocysteine methyltransferase', BIOCHEMICAL AND MOLECULAR MEDICINE, 61 28-40 (1997)
DOI 10.1006/bmme.1997.2580
Citations Scopus - 23Web of Science - 21
1997 Lucock MD, Lumb CH, Wild J, Daskalakis I, Schorah CJ, Kendall R, Levene MI, 'Methyl group utilisation versus production in NTD and control subjects: Influence of vitamin B12.', PTERIDINES, 8 156-157 (1997)
1997 Lucock MD, Lumb CH, Wild J, Oliver M, Daskalakis I, Schorah CJ, et al., 'Elevated homocysteine in subjects with a previous NTD pregnancy is associated with increased hexaglutamyl methylfolate consistent with impaired B12 Dependant Methionine Synthase activity.', PTERIDINES, 8 85-86 (1997)
1997 Lucock MD, Daskalakis I, Lumb CH, OLIVER M, Wild J, Schorah CJ, Levene MI, 'One carbon metabolic parameters and NTD', PTERIDINES, 8 155-155 (1997)
1997 Lucock MD, Lumb CH, Wild J, Oliver M, Daskalakis I, Schorah CJ, et al., 'Methionine synthase activity is dependant upon intracellular methylfolate levels in control but not NTD subjects where utilisation of hexaglutamyl methylfolate is limiting for remethylation of homocysteine.', PTERIDINES, 8 156-156 (1997)
1996 Schorah CJ, Wild J, Lucock M, 'Folate dose may mask small differences in folate metabolism', AMERICAN JOURNAL OF CLINICAL NUTRITION, 63 976-976 (1996)
1996 Daskalakis I, Lucock MD, Anderson A, Wild J, Schorah CJ, Levene MI, 'Determination of plasma total homocysteine and cysteine using HPLC with fluorescence detection and an ammonium 7-fluoro-2,1,3-benzoxadiazole-4-sulphonate (SBD-F) derivatization protocol optimized for antioxidant concentration, derivatization reagent concentration, temperature and matrix pH', BIOMEDICAL CHROMATOGRAPHY, 10 205-212 (1996)
DOI 10.1002/(SICI)1099-0801(199609)10:5&lt;205::AID-BMC589&gt;3.3.CO;2-G
Citations Scopus - 55Web of Science - 50
1996 Lucock MD, Daskalakis I, Schorah CJ, Levene MI, Hartley R, 'Analysis and biochemistry of blood folate', BIOCHEMICAL AND MOLECULAR MEDICINE, 58 93-112 (1996)
DOI 10.1006/bmme.1996.0037
Citations Scopus - 18Web of Science - 18
1996 Lucock MD, Daskalakis IG, Wild J, Anderson A, Schorah CJ, Lean MEJ, Levene MI, 'The influence of dietary folate and methionine on the metabolic disposition of endotoxic homocysteine', BIOCHEMICAL AND MOLECULAR MEDICINE, 59 104-111 (1996)
DOI 10.1006/bmme.1996.0074
Citations Scopus - 18Web of Science - 19
1995 LUCOCK MD, GREEN M, PRIESTNALL M, DASKALAKIS I, LEVENE MI, HARTLEY R, 'OPTIMIZATION OF CHROMATOGRAPHIC CONDITIONS FOR THE DETERMINATION OF FOLATES IN FOODS AND BIOLOGICAL TISSUES FOR NUTRITIONAL AND CLINICAL-WORK', FOOD CHEMISTRY, 53 329-338 (1995)
DOI 10.1016/0308-8146(95)93941-J
Citations Scopus - 31Web of Science - 31
1995 LUCOCK MD, GREEN M, LEVENE MI, 'METHYLFOLATE MODULATES POTASSIUM-EVOKED NEURO-SECRETION - EVIDENCE FOR A ROLE AT THE PTERIDINE COFACTOR LEVEL OF TYROSINE 3-HYDROXYLASE', NEUROCHEMICAL RESEARCH, 20 727-736 (1995)
DOI 10.1007/BF01705542
Citations Scopus - 9Web of Science - 6
1995 LUCOCK MD, PRIESTNALL M, DASKALAKIS I, SCHORAH CJ, WILD J, LEVENE MI, 'NONENZYMATIC DEGRADATION AND SALVAGE OF DIETARY-FOLATE - PHYSICOCHEMICAL FACTORS LIKELY TO INFLUENCE BIOAVAILABILITY', BIOCHEMICAL AND MOLECULAR MEDICINE, 55 43-53 (1995)
DOI 10.1006/bmme.1995.1030
Citations Scopus - 42Web of Science - 36
1995 WILD J, LUCOCK MD, SCHORAH CJ, 'PERICONCEPTIONAL FOLATE AND NEURAL-TUBE DEFECTS', AMERICAN JOURNAL OF CLINICAL NUTRITION, 61 615-616 (1995)
Citations Scopus - 1Web of Science - 1
1995 HABIBZADEH N, WILD J, LUCOCK MD, SCHORAH CJ, 'ONE-CARBON METABOLISM IN PREGNANCIES COMPLICATED BY NEURAL-TUBE DEFECTS', LANCET, 345 791-791 (1995)
DOI 10.1016/S0140-6736(95)90669-X
Citations Scopus - 2
1995 LUCOCK MD, WILD J, LEVENE MI, 'ENZYME DEFECT AS A RISK FACTOR FOR SPINA-BIFIDA', LANCET, 346 1495-1496 (1995)
DOI 10.1016/S0140-6736(95)92517-1
Citations Scopus - 5Web of Science - 5
1994 LUCOCK MD, NAYEEMUDDIN FA, HABIBZADEH N, SCHORAH CJ, HARTLEY R, LEVENE MI, 'METHYLFOLATE EXHIBITS A NEGATIVE IN-VITRO INTERACTION WITH IMPORTANT DIETARY METAL-CATIONS', FOOD CHEMISTRY, 50 307-310 (1994)
DOI 10.1016/0308-8146(94)90138-4
Citations Scopus - 6Web of Science - 5
1994 LUCOCK MD, WILD J, SCHORAH CJ, LEVENE MI, HARTLEY R, 'THE METHYLFOLATE AXIS IN NEURAL-TUBE DEFECTS - IN-VITRO CHARACTERIZATION AND CLINICAL INVESTIGATION', BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY, 52 101-114 (1994)
DOI 10.1006/bmmb.1994.1040
Citations Scopus - 36Web of Science - 33
1993 LUCOCK MD, GREEN M, HARTLEY R, LEVENE MI, 'PHYSICOCHEMICAL AND BIOLOGICAL FACTORS INFLUENCING METHYLFOLATE STABILITY - USE OF DITHIOTHREITOL FOR HPLC ANALYSIS WITH ELECTROCHEMICAL DETECTION', FOOD CHEMISTRY, 47 79-86 (1993)
DOI 10.1016/0308-8146(93)90307-2
Citations Scopus - 13Web of Science - 14
1993 LUCOCK MD, LEVENE MI, HARTLEY R, 'MODULATION OF POTASSIUM EVOKED SECRETORY FUNCTION IN RAT CEREBELLAR SLICES MEASURED BY REAL-TIME MONITORING - EVIDENCE OF A POSSIBLE ROLE FOR METHYLFOLATE IN CEREBRAL TISSUE', NEUROCHEMICAL RESEARCH, 18 617-623 (1993)
DOI 10.1007/BF00966940
Citations Scopus - 8Web of Science - 6
1991 LUCOCK MD, WILD J, HARTLEY R, LEVENE MI, SCHORAH CJ, 'VITAMINS TO PREVENT NEURAL-TUBE DEFECTS', LANCET, 338 894-895 (1991)
Citations Scopus - 4Web of Science - 3
1991 HARTLEY R, GREEN M, LUCOCK MD, RYAN S, FORSYTHE WI, 'SOLID-PHASE EXTRACTION OF OXCARBAZEPINE AND ITS METABOLITES FROM PLASMA FOR ANALYSIS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY', BIOMEDICAL CHROMATOGRAPHY, 5 212-215 (1991)
DOI 10.1002/bmc.1130050507
Citations Scopus - 18Web of Science - 13
1991 HARTLEY R, FORSYTHE WI, MCLAIN B, NG PC, LUCOCK MD, 'DAILY VARIATIONS IN STEADY-STATE PLASMA-CONCENTRATIONS OF CARBAMAZEPINE AND ITS METABOLITES IN EPILEPTIC CHILDREN', CLINICAL PHARMACOKINETICS, 20 237-244 (1991)
Citations Scopus - 22Web of Science - 22
1990 HARTLEY R, LUCOCK MD, NG PC, FORSYTHE WI, MCLAIN B, BOWMER CJ, 'FACTORS INFLUENCING PLASMA-LEVEL DOSE RATIOS OF CARBAMAZEPINE AND ITS MAJOR METABOLITES IN EPILEPTIC CHILDREN', THERAPEUTIC DRUG MONITORING, 12 438-444 (1990)
DOI 10.1097/00007691-199009000-00006
Citations Scopus - 19Web of Science - 17
1989 LUCOCK MD, HARTLEY R, SMITHELLS RW, 'A RAPID AND SPECIFIC HPLC-ELECTROCHEMICAL METHOD FOR THE DETERMINATION OF ENDOGENOUS 5-METHYLTETRAHYDROFOLIC ACID IN PLASMA USING SOLID-PHASE SAMPLE PREPARATION WITH INTERNAL STANDARDIZATION', BIOMEDICAL CHROMATOGRAPHY, 3 58-63 (1989)
DOI 10.1002/bmc.1130030204
Citations Scopus - 39Web of Science - 35
1989 LUCOCK MD, WILD J, SMITHELLS RW, HARTLEY R, 'INVIVO CHARACTERIZATION OF THE ABSORPTION AND BIOTRANSFORMATION OF PTEROYLMONOGLUTAMIC ACID IN MAN - A MODEL FOR FUTURE STUDIES', BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY, 42 30-42 (1989)
DOI 10.1016/0885-4505(89)90038-8
Citations Scopus - 41Web of Science - 37
1989 LUCOCK M, WILD J, SMITHELLS R, HARTLEY R, 'BIOTRANSFORMATION OF PTEROYLMONOGLUTAMIC ACID DURING ABSORPTION - IMPLICATIONS OF MICHAELIS-MENTEN KINETICS', EUROPEAN JOURNAL OF CLINICAL NUTRITION, 43 631-635 (1989)
Citations Scopus - 27Web of Science - 28
1988 Forsythe WI, Hartley R, Lucock MD, McClain B, Ng P, 'Diurnal variation of carbamazepine plasma levels in epileptic children at steady state: Clinical implications and interpretations.', IRISH JOURNAL OF MEDICAL SCIENCE, 278-278 (1988)
1987 LUCOCK M, HARTLEY R, WILD NJ, 'HPLC DETERMINATION OF VITAMIN-K1 IN NEONATAL PLASMA FOLLOWING ORAL OR PARENTERAL SUPPLEMENTATION WITH KONAKION', JOURNAL OF LIQUID CHROMATOGRAPHY, 10 191-203 (1987)
DOI 10.1080/01483918708074200
Citations Scopus - 5Web of Science - 4
1987 HARTLEY R, LUCOCK M, FORSYTHE WI, SMITHELLS RW, 'SOLID-PHASE EXTRACTION OF CARBAMAZEPINE AND 2 MAJOR METABOLITES FROM PLASMA FOR ANALYSIS BY HPLC', JOURNAL OF LIQUID CHROMATOGRAPHY, 10 2393-2409 (1987)
DOI 10.1080/01483918708068920
Citations Scopus - 12Web of Science - 16
1987 HARTLEY R, LUCOCK M, BECKER M, 'IMPROVED HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC PROCEDURE FOR THE DETERMINATION OF CHLORMETHIAZOLE LEVELS FOLLOWING SOLID-PHASE EXTRACTION FROM PLASMA', JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 415 357-364 (1987)
DOI 10.1016/S0378-4347(00)83227-2
Citations Scopus - 7Web of Science - 5
1986 PICKARD CE, STEWART AD, HARTLEY R, LUCOCK MD, 'A RAPID HPLC METHOD FOR MONITORING PLASMA-LEVELS OF CAFFEINE AND THEOPHYLLINE USING SOLID-PHASE EXTRACTION COLUMNS', ANNALS OF CLINICAL BIOCHEMISTRY, 23 440-446 (1986)
Citations Scopus - 29Web of Science - 30
1986 HARTLEY R, LUCOCK M, BECKER M, SMITH IJ, FORSYTHE WI, 'SOLID-PHASE EXTRACTION OF ACETAZOLAMIDE FROM BIOLOGICAL-FLUIDS AND SUBSEQUENT ANALYSIS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY', JOURNAL OF CHROMATOGRAPHY, 377 295-305 (1986)
DOI 10.1016/S0378-4347(00)80785-9
Citations Scopus - 25Web of Science - 25
1986 HARTLEY R, LUCOCK M, COOKMAN JR, BECKER M, SMITH IJ, SMITHELLS RW, FORSYTHE WI, 'HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF CARBAMAZEPINE AND CARBAMAZEPINE 10,11-EPOXIDE IN PLASMA AND SALIVA FOLLOWING SOLID-PHASE SAMPLE EXTRACTION', JOURNAL OF CHROMATOGRAPHY, 380 347-356 (1986)
DOI 10.1016/S0378-4347(00)83663-4
Citations Scopus - 22Web of Science - 19
Show 125 more journal articles

Review (3 outputs)

Year Citation Altmetrics Link
2014 Beckett EL, Yates Z, Veysey M, Duesing K, Lucock M, 'The role of vitamins and minerals in modulating the expression of microRNA', Nutrition Research Reviews (2014) [C1]

A growing number of studies in recent years have highlighted the importance of molecular nutrition as a potential determinant of health and disease. In particular, the ability of ... [more]

A growing number of studies in recent years have highlighted the importance of molecular nutrition as a potential determinant of health and disease. In particular, the ability of micronutrients to regulate the final expression of gene products via modulation of transcription and translation is now being recognised. Modulation of microRNA (miRNA) by nutrients is one pathway by which nutrition may mediate gene expression. MiRNA, a class of non-coding RNA, can directly regulate gene expression post-transcriptionally. In addition, miRNA are able to indirectly influence gene expression potential at the transcriptional level via modulation of the function of components of the epigenetic machinery (DNA methylation and histone modifications). These mechanisms interact to form a complex, bi-directional regulatory circuit modulating gene expression. Disease-specific miRNA profiles have been identified in multiple disease states, including those with known dietary risk factors. Therefore, the role that nutritional components, in particular, vitamins and minerals, play in the modulation of miRNA profiles, and consequently health and disease, is increasingly being investigated, and as such is a timely subject for review. The recently posited potential for viable exogenous miRNA to enter human blood circulation from food sources adds another interesting dimension to the potential for dietary miRNA to contribute to gene modulation. © 2014 The Authors.

DOI 10.1017/S0954422414000043
Citations Scopus - 7Web of Science - 8
Co-authors Emma Beckett, Zoe Yates, Martin Veysey
2014 Beckett EL, Yates Z, Veysey M, Duesing K, Lucock M, 'The role of vitamins and minerals in modulating the expression of microRNA', Nutrition Research Reviews (2014)

Copyright © The Authors 2014. A growing number of studies in recent years have highlighted the importance of molecular nutrition as a potential determinant of health and disease.... [more]

Copyright © The Authors 2014. A growing number of studies in recent years have highlighted the importance of molecular nutrition as a potential determinant of health and disease. In particular, the ability of micronutrients to regulate the final expression of gene products via modulation of transcription and translation is now being recognised. Modulation of microRNA (miRNA) by nutrients is one pathway by which nutrition may mediate gene expression. miRNA, a class of non-coding RNA, can directly regulate gene expression post-transcriptionally. In addition, miRNA are able to indirectly influence gene expression potential at the transcriptional level via modulation of the function of components of the epigenetic machinery (DNA methylation and histone modifications). These mechanisms interact to form a complex, bi-directional regulatory circuit modulating gene expression. Disease-specific miRNA profiles have been identified in multiple disease states, including those with known dietary risk factors. Therefore, the role that nutritional components, in particular, vitamins and minerals, play in the modulation of miRNA profiles, and consequently health and disease, is increasingly being investigated, and as such is a timely subject for review. The recently posited potential for viable exogenous miRNA to enter human blood circulation from food sources adds another interesting dimension to the potential for dietary miRNA to contribute to gene modulation.

DOI 10.1017/S0954422414000043
Citations Scopus - 2
Co-authors Zoe Yates, Martin Veysey, Emma Beckett
2014 Beckett EL, Martin C, Yates Z, Veysey M, Duesing K, Lucock M, 'Bitter taste genetics-the relationship to tasting, liking, consumption and health', Food and Function (2014) [C1]

© 2014 The Royal Society of Chemistry. Bitter is the most complex of human tastes, and is arguably the most important. Aversion to bitter taste is important for detecting toxic c... [more]

© 2014 The Royal Society of Chemistry. Bitter is the most complex of human tastes, and is arguably the most important. Aversion to bitter taste is important for detecting toxic compounds in food; however, many beneficial nutrients also taste bitter and these may therefore also be avoided as a consequence of bitter taste. While many polymorphisms in TAS2R genes may result in phenotypic differences that influence the range and sensitivity of bitter compounds detected, the full extent to which individuals differ in their abilities to detect bitter compounds remains unknown. Simple logic suggests that taste phenotypes influence food preferences, intake and consequently health status. However, it is becoming clear that genetics only plays a partial role in predicting preference, intake and health outcomes, and the complex, pleiotropic relationships involved are yet to be fully elucidated. This journal is

DOI 10.1039/c4fo00539b
Citations Scopus - 4Web of Science - 3
Co-authors Martin Veysey, Zoe Yates, Emma Beckett

Conference (61 outputs)

Year Citation Altmetrics Link
2017 Beckett EL, Martin C, King K, Niblett S, Ferguson J, Abbott K, et al., 'Omega-3 Index Predicts Cognitive Impairment Score in an MTHFR-C677T Dependent Manner', Omega-3 Index Predicts Cognitive Impairment Score in an MTHFR-C677T Dependent Manner (2017)
DOI 10.1159/000480052
Co-authors Martin Veysey, Katrina King, Emma Beckett, Manohar Garg
2016 Beckett EL, Duesing K, Boyd L, Yates Z, Veysey M, Lucock MD, 'The influence of bitter taste phenotype on alcohol consumption; the presence of a sex dimorphism', Journal of the Australasian College of Nutritional and Environmental Medicine (2016)
Co-authors Emma Beckett, Martin Veysey, Zoe Yates
2016 Beckett EL, Duesing K, Martin C, Jones P, Furst J, King K, et al., 'Plasma calcidiol and serum folate levels independently predict the methylation status of the vitamin D receptor gene CpG island' (2016)
Co-authors Zoe Yates, John Furst, Katrina King, Martin Veysey, Emma Beckett
2016 Beckett EL, Duesing K, Martin C, Jones P, Furst J, King K, et al., 'Plasma 25-hydroxycholecalciferol and serum folate levels are independent predictors of the methylation status of the vitamin D receptor gene' (2016)
Co-authors Emma Beckett, John Furst, Martin Veysey, Zoe Yates, Katrina King
2016 Beckett EL, Duesing K, Boyd L, Ng X, Yates Z, Veysey M, Lucock M, 'Bitter taste phenotype and TAS2R38 A49P genotype influence alcohol consumption in males but not females', Journal of Nutrition & Intermediary Metabolism (2016)
DOI 10.1016/j.jnim.2015.12.188
Co-authors Emma Beckett
2015 Garg M, Abbott K, Veysey M, Lucock M, Niblett S, King K, Burrows T, 'Association Between Omega-3 Index and Type 2 Diabetes in Older Overweight/Obese People is Sex Dependent', FASEB JOURNAL (2015) [E3]
Co-authors Manohar Garg, Martin Veysey, Tracy Burrows, Katrina King
2015 Kheir AO, King K, Niblett S, Martin C, Beckett E, Yates Z, et al., 'The relationship between non-alcoholic fatty liver disease and homocysteine', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2015) [E3]
Co-authors Katrina King, Martin Veysey, Zoe Yates, Emma Beckett
2015 Beckett E, Duesing K, Yates Z, Lucock M, Veysey M, 'miR-21 as a biomarker for adenomatous colon polyps: a potential sex dimorphism', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2015) [E3]
Co-authors Martin Veysey, Zoe Yates, Emma Beckett
2015 Siow W, Niblett S, King K, Yates Z, Lucock M, Veysey M, 'NAFLD fibrosis score predicts an increased risk of colorectal polyps', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2015) [E3]
Co-authors Katrina King, Martin Veysey, Zoe Yates
2015 Beckett EL, Martin C, Choi JH, Boyd L, Duesing K, Yates Z, et al., 'Correlation between nutrient intake and circulating microRNA-21' (2015)
Co-authors Emma Beckett, Zoe Yates, Martin Veysey
2015 Beckett EL, veysey M, Boyd L, Ng X, yates Z, Duesing K, Lucock MD, 'Bitter taste phenotype influences total energy intake but not composition' (2015)
Co-authors Martin Veysey, Emma Beckett, Zoe Yates
2015 Martin CE, Beckett EL, Yates Z, Veysey M, Lucock MD, 'Dietary vitamin B12 intake and cognitive decline in an Australian population' (2015)
Co-authors Martin Veysey, Zoe Yates, Emma Beckett
2015 Veysey M, King K, Niblett SH, Martin C, Beckett EL, Yates ZR, et al., 'Homocysteine Status Is a Predictor of Non-Alcoholic Fatty Liver Disease and Is Genotype Dependent', GASTROENTEROLOGY (2015) [E3]
Co-authors Katrina King, Martin Veysey, Zoe Yates, Emma Beckett
2014 Siow W, Niblett SH, King K, Yates ZR, Lucock M, Veysey M, 'Prevalence and Associations of Non-Alcoholic Fatty Liver Disease in the Elderly', GASTROENTEROLOGY (2014)
Co-authors Martin Veysey, Katrina King, Zoe Yates
2014 Siow W, Niblett SH, King K, Yates ZR, Lucock M, Veysey M, 'Fatty Liver Index and NAFLD Fibrosis Score in an Elderly Population', GASTROENTEROLOGY (2014)
Co-authors Katrina King, Martin Veysey, Zoe Yates
2014 Veysey M, Siow W, Niblett S, King K, Yates Z, Lucock M, 'Hepatic fibrosis in an elderly population', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Co-authors Katrina King, Martin Veysey, Zoe Yates
2014 Veysey M, Siow W, Niblett S, King K, Yates Z, Lucock M, 'White cell counts and non-alcoholic fatty liver disease', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Co-authors Martin Veysey, Zoe Yates
2014 Beckett EL, Veysey M, Duesing K, Yates Z, Lucock MD, 'Low density lipoprotein and total cholesterol levels predict circulating miR-152 expression in males, but not females, in an elderly cohort' (2014)
Co-authors Zoe Yates, Martin Veysey, Emma Beckett
2013 Veysey M, Siow W, Choi J-H, Martin C, Tang S, Yates ZR, Lucock M, 'A Bitter Taste Gene (P49a Variant of Tas2r38) Interacts With A1298c-MTHFR to Modify Risk for Adenomas in an Australian Population', GASTROENTEROLOGY (2013) [E3]
Co-authors Martin Veysey, Zoe Yates
2013 Choi J, Siow W, Yates Z, Lucock M, Veysey M, 'Influence of synthetic folic acid concentration on Caco-2 cell growth', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013) [E3]
Co-authors Martin Veysey, Zoe Yates
2013 Siow W, Niblett S, King K, Yates Z, Hampe T, Lucock M, Veysey M, 'Prevalence of non-alcoholic fatty liver disease in an elderly Australian population', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013) [E3]
Co-authors Katrina King, Martin Veysey, Zoe Yates
2013 Siow W, Niblett S, King K, Yates Z, Martin C, Lucock M, Veysey M, 'A community-based study of dietary macro and micronutrients and the risk of colorectal cancer in an elderly Australian population', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013) [E3]
Co-authors Katrina King, Martin Veysey, Zoe Yates
2013 Martin C, Lucock MD, Yates Z, Veysey M, 'Changing patterns of dietary B-vitamin intake and influence of the related C677T-MTHFR polymorphism in an elderly population: Effect on the hypertensive phenotype' (2013)
Co-authors Zoe Yates, Martin Veysey
2013 Beckett E, Martin C, Duesing K, Yates Z, Veysey, Lucock MD, 'Circulating miRNAs (155, 15a and 182) correlate with blood folate in an MTHFR genotype dependent manner' (2013)
Co-authors Zoe Yates, Emma Beckett, Martin Veysey
2011 Choi J-H, Yates ZR, Boyd L, Veysey MJ, Lucock MD, 'Dietary folate vitamers as potential risk factors in the aetiology of adenomatous polyps', Australasian Medical Journal (2011) [E3]
Co-authors Zoe Yates, Martin Veysey
2011 Yates ZR, Kho J, Choi J-H, Boyd L, Ng X, Skinner V, et al., 'C776G TCNII genotype influences the relationship between blood vitamin B12 and cellular folate', Australasian Medical Journal (2011) [E3]
Co-authors Zoe Yates, Martin Veysey
2011 Naylor C, Lucock MD, Veysey MJ, Naumovski N, Boyd L, Dufficy L, et al., 'Folate nutritional genetics and degenerative disorders in the elderly with special reference to hypertension and depression', Australasian Medical Journal (2011) [E3]
Co-authors Zoe Yates, Martin Veysey, Paul Roach
2010 Niblett S, King K, Lucock MD, Roach P, Lewis P, Kennedy D, et al., 'Is Retirement village living good for health? Comparing the health of older adults living in retirement villages and the community' (2010)
Co-authors Zoe Yates, Martin Veysey, Paul Roach, Katrina King
2010 Chang J, Lucock MD, Wai R, Boyd L, Ng X, Skinner VM, et al., 'Dietary folic acid, red cell folate and the risk of adenomatous polyps in an Australian population', Journal of Gastroenterology and Hepatology. Special Issue: Australian Gastroenterology Week 2010 (2010) [E3]
Co-authors Martin Veysey, Zoe Yates, Paul Roach
2009 Veysey MJ, Boyd L, Wai R, Ng X, Skinner V, Tang S, et al., 'Preliminary data to support a relationship between taste genetics, folate status, folate genes and the development of colonic adenomas: A novel nutrigenomic circuit', Gastro 2009 UEGW/WCOG: Scientific Programme & EACCME (2009) [E3]
Co-authors Martin Veysey, Zoe Yates, Paul Roach
2009 Boyd L, Lucock MD, Wai R, Ng X, Yates ZR, Skinner V, et al., 'Folate status: A recognised determinant of colorectal neoplasia may be modified by bitter taste perception and genetics', Proceedings of the Nutrition Society of Australia (2009) [E3]
Co-authors Martin Veysey, Zoe Yates, Paul Roach
2008 Yates ZR, Lucock MD, 'Folate and the C677T-MTHFR variant: Impact on population health', Journal of Nutrigenetics and Nutrigenomics (2008) [E3]
DOI 10.1159/000128589
Co-authors Zoe Yates
2008 Ng X, Boyd L, Dufficy L, Naumovski N, Blades BL, Travers C, et al., 'Folate genes and risk for hypertension in an elderly population sample', 3rd Asia Pacific Nutrigenomics Conference: Conference Program & Information (2008) [E3]
Co-authors Paul Roach, Martin Veysey, Zoe Yates
2008 Wai RKH, Boyd L, Ng X, King K, Skinner V, Roach PD, et al., 'Preliminary evidence that bitter taste perception can modify folate status: A recognised risk factor for colorectal neoplasia', Journal of Gastroenterology and Hepatology (2008) [E3]
Co-authors Zoe Yates, Martin Veysey, Paul Roach
2008 Boyd L, Wai RKH, Ng X, King K, Skinner V, Roach PD, et al., 'A preliminary study to examine whether common folate polymorphisms are risk factors for the development of adenomatous polyps', Journal of Gastroenterology and Hepatology (2008) [E3]
Co-authors Martin Veysey, Zoe Yates, Paul Roach
2007 Pengelly AR, Lucock MD, Roach PD, 'A method for assessing the variation in Flavonoid levels of Dodonaea viscosa subspecies Angustifolia, a traditional wound healing medicinal herb', 50 Years of the Phytochemical Society of Europe: Highlights in the Evolution of Phytochemistry. Abstract Book (2007) [E3]
Co-authors Paul Roach
2007 Veysey M, Lucock MD, Roach P, Lewis P, Skinner V, Niblett S, et al., 'Is Retirement Village Living Good for You? The Central Coast Centre for Vascular Health Retirement Village Health & Lifestyle Study' (2007)
Co-authors Paul Roach, Martin Veysey, Zoe Yates
2006 Roach PD, Dufficy L, Naumovski N, Ng X, Blades BL, Travers C, et al., 'The association of dietary folate with serum and red cell folate is modulated by the G80A reduced folate carrier single nucloetide polymorphism in an elderly population sample', The Proceedings of the Nutrition Society of Australia (2006) [E3]
Co-authors Martin Veysey, Paul Roach
2006 Blades BL, Naumovski N, Roach PD, Lucock MD, Travers C, Lewis PR, et al., 'Vitamin B12 is a better inverse correlate for homocysteine than folate in an elderly population sample', Atherosclerosis Supplements (2006) [E3]
Co-authors Paul Roach, Martin Veysey
2006 Roach PD, Naumovski N, Blades BL, Lucock MD, Travers C, Lewis PR, et al., 'Serum vitamin B12 is inversely related to blood pressure and anxiety in elderly women but not in elderly men', Atherosclerosis Supplements (2006) [E3]
Co-authors Martin Veysey, Paul Roach
2006 Naumovski N, Blades BL, Lucock MD, Travers C, Lewis PR, Sturm J, Veysey MJ, 'Serum vitamin B12 is inversely related to blood pressure and anxiety in women but not men in an elderly population sample', Heart Foundation Conference and Scientific Meeting (2006) [E3]
Co-authors Martin Veysey
2006 Naumovski N, Roach PD, Blades BL, Lucock MD, Travers C, Lewis PR, et al., 'Homocysteine, vitamin B12 and folate in an elderly population sample', Heart Foundation Conference and Scientific Meeting (2006) [E3]
Co-authors Paul Roach, Martin Veysey
2006 Roach PD, Dufficy L, Naumovski N, Ng X, Blades BL, Travers C, et al., 'The association of blood pressure with dietary folate in elderly females and its modulation by the G80A reduced folate carrier SNP', Program & Abstracts Australian Atherosclerosis Society (2006) [E3]
Co-authors Martin Veysey, Paul Roach
2006 Veysey M, Lewis P, Lucock MD, Roach P, Kennedy D, Skinner V, niblett S, 'Is retirement village living good for you? Evaluating the health and lifestyle of older adults living in retirement villages compared to those living within the community.' (2006)
Co-authors Martin Veysey, Paul Roach
2006 Skinner V, Niblett S, Naumovski N, Blades B, Roach P, Lucock MD, et al., 'Is it good for your cardiovascular health to live in a retirement village?' (2006)
Co-authors Paul Roach, Martin Veysey
2005 Roach PD, Naumovski N, Dufficy L, Lucock MD, Blades BL, Lewis (Ext) PR, et al., 'Folate, viamin B12, plasma thiols and cognitive funciton in an elderly population sample', Asia Pacific Journal of Clinical Nutrition (2005) [E3]
Co-authors Paul Roach, Martin Veysey
2005 Roach PD, Blades BL, Lucock MD, Naumovski N, Dufficy L, Lewis (Ext) PR, et al., 'Serum Vitamin B12 is Inversely Related to Blood Pressure in Women but not Men in an Elderly Population Sample', Proceedings of Annual Scientific Meeting 2005 (2005) [E3]
Co-authors Martin Veysey, Paul Roach
2004 Novakovic P, Sohn KJ, Chiang EP, Dickhout J, Yates Z, Lucock M, et al., 'Effect of MTHFR C677T polymorphism on the intracellular methionine cycle and DNA methylation in colon cancer cells', FASEB JOURNAL (2004)
Co-authors Zoe Yates
2004 Moskovitz DN, Sohn KJ, Smirnakis F, Novakovic P, Yates ZR, Lucock MD, et al., 'Effects of folylpolyglutamyl synthetase modulation on chemosensitivity of colon cancer cells to 5 fluorouracil and methotrexate', CDDW Abstracts (2004) [E3]
Co-authors Zoe Yates
2003 Glanville T, Yates Z, Hopkins S, Walker JJ, Lucock M, Simpson N, 'Growth restriction is associated with fetal carriage of A66G methionine synthase reductase SNP', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2003) [E1]
DOI 10.1016/j.ajog.2003.10.618
Citations Web of Science - 1
2002 Glanville T, Yates Z, Ovadia L, Walker JJ, Lucock M, Simpson N, 'Folate gene MTHFR C677T polymorphism and fetal growth restriction', Journal of Obstetrics and Gynaecology, 22(Supp1) S31-S32 (2002) [E1]
2002 Lucock M, Yates Z, Goodall E, Achilli G, '12 Channel coulometric electrochemical detection for the identification of polyglutamate homology amongst cellular folates' (2002) [E1]
2002 Lucock M, Yates Z, Cade A, 'Gastro intestinal pH modulates facile interconvertion of native formylfolates during absorption' (2002) [E1]
2002 Yates Z, Lucock M, 'C677T MTHFR Genotype is a Risk Factor for Thromboembolism: Comparison of T Allele Frequency and Homocysteine Level between Female Thromboembolic and Non-Thromboembolic Vascualr Patients, NTD Mother and Matched NTD Controls' (2002) [E1]
2002 Glanville T, Yates Z, Ovadia L, Walker JJ, Lucock MD, Simpson NAB, 'Folate polymorphisms C677T Methylenetetrahydrofolate reductase and A2756G Methionine synthase and fetal growth restriction' (2002)
Co-authors Zoe Yates
2000 Blackburn A, Yates Z, Lucock MD, Bibby MC, Nicolaou A, 'Folate profiling in a methionine dependent mouse colon tumour model.' (2000)
Co-authors Zoe Yates
1999 Hodge D, Holland PC, Penter R, Lucock MD, Overend H, Grant P, 'Vascular endothelial factors in children with insulin dependent diabetes.' (1999)
1997 Lucock MD, Lumb C, Wild J, Oliver M, Daskalakis I, Schorah C, et al., 'Elevated homocysteine in subjects with a previous NTD pregnancy is associated with increased hexaglutamyl methylfolate consistent with impaired B-12 dependent methionine synthase activity.', CHEMISTRY AND BIOLOGY OF PTERIDINES AND FOLATES 1997 (1997)
Citations Web of Science - 1
1997 Lucock MD, Daskalakis IG, Lumb C, Oliver M, Wild J, Schorah C, Levene MI, 'One carbon metabolic parameters and NTD.', CHEMISTRY AND BIOLOGY OF PTERIDINES AND FOLATES 1997 (1997)
1997 Lucock MD, Lumb C, Wild J, Oliver M, Daskalakis I, Schorah CJ, et al., 'Methionine synthase activity is dependent upon intracellular methylfolate level in control but not NTD subjects where utilization of hexaglutamyl methylfolate is limiting for remethylation of homocysteine.', CHEMISTRY AND BIOLOGY OF PTERIDINES AND FOLATES 1997 (1997)
Citations Web of Science - 2
1997 Lucock MD, Lumb C, Wild J, Daskalakis I, Schorah CJ, Kendall R, Levene MI, 'Methyl group utilization versus production in NTD and control subjects: Influence of vitamin B-12', CHEMISTRY AND BIOLOGY OF PTERIDINES AND FOLATES 1997 (1997)
Show 58 more conferences

Other (2 outputs)

Year Citation Altmetrics Link
2013 Beckett EL, Lucock, 'Health Check: the untrue story of antioxidants vs free radicals', The Conversation (2013)
Co-authors Emma Beckett
2013 Lucock MD, 'Nutrigenomics: how nutrition and genetics impact health', The Conversation (2013)

Thesis / Dissertation (1 outputs)

Year Citation Altmetrics Link
1991 Lucock MD, Improved HPLC analysis of folylmonoglutamates: Application in selected nutritional and metabolic studies, University of Leeds (1991)
Edit

Grants and Funding

Summary

Number of grants 30
Total funding $1,306,695

Click on a grant title below to expand the full details for that specific grant.


20173 grants / $91,045

Researcher Equipment Grant$49,789

UON 2017 Researcher Equipment Grant

Institution Number: G1701160

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team

Emma Beckett, Chris Scarlett, Jude Weidenhofer, Dean Sculley, Martin Veysey, Zoe Yates, Danielle Bond

Scheme Researcher Equipment Grant
Role Investigator
Funding Start 2017
Funding Finish 2017
GNo
Type Of Funding Internal
Category INTE
UON N

Light Sensitive Vitamins - Relationship with Environmental and Genetic Factors$31,531

Funding body: Central Coast Local Health District

Funding body Central Coast Local Health District
Project Team Associate Professor Mark Lucock, Associate Professor Martin Veysey, Doctor Emma Beckett
Scheme Research Grant
Role Lead
Funding Start 2017
Funding Finish 2020
GNo G1700259
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Taste receptor genetics, the microbiota and metabolic disease risk – a pilot study $9,725

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Emma Beckett, Associate Professor Mark Lucock
Scheme Ourimbah Strategic Pilot Grant
Role Investigator
Funding Start 2017
Funding Finish 2017
GNo G1701265
Type Of Funding Internal
Category INTE
UON Y

20121 grants / $24,500

Phase I and II detoxification genes; the correlation of epigenetic modifications with nutritional status, lifestyle factors, health and disease$24,500

Funding body: CSIRO - Energy Technology

Funding body CSIRO - Energy Technology
Project Team Associate Professor Mark Lucock, Associate Professor Martin Veysey, Doctor Zoe Yates, Miss Emma Beckett, Dr Konsta Duesing
Scheme Postgraduate Research Scholarship
Role Lead
Funding Start 2012
Funding Finish 2015
GNo G1200845
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20102 grants / $103,420

Vitamin-related nutrigenetic research to support PhD studies$67,056

Consumable budget to support a number of PhD projects on vitamin-related nutrigenetic research

Funding body: Central Coast Health Teaching & Research Unit

Funding body Central Coast Health Teaching & Research Unit
Project Team

Mark Lucock, Martin Veysey

Scheme Postgraduate Research Scholarship
Role Lead
Funding Start 2010
Funding Finish 2017
GNo
Type Of Funding Other Public Sector - State
Category 2OPS
UON N

Is retirement village living good for health: Comparing the health of older adults living in retirement villages and the community$36,364

Funding body: Valhalla Village Pty Ltd

Funding body Valhalla Village Pty Ltd
Project Team Associate Professor Martin Veysey, Dr Peter Lewis, Associate Professor Mark Lucock, Doctor Paul Roach, Dr David Kennedy
Scheme Linkage Projects Partner Funding
Role Investigator
Funding Start 2010
Funding Finish 2011
GNo G1000936
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

20091 grants / $61,281

The Association between Folate Nutritional Status and Folate Gene Polymorphisms in an Elderly Australian Population$61,281

Funding body: Central Coast Local Health District

Funding body Central Coast Local Health District
Project Team Associate Professor Martin Veysey, Doctor Zoe Yates, Associate Professor Mark Lucock, Doctor Paul Roach
Scheme Research Sponsorship Scholarship
Role Investigator
Funding Start 2009
Funding Finish 2011
GNo G0190658
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

20084 grants / $685,923

Is retirement village living good for health: Comparing the health of older adults living in retirement villages and the community$390,173

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Associate Professor Martin Veysey, Dr Peter Lewis, Associate Professor Mark Lucock, Doctor Paul Roach, Dr David Kennedy
Scheme Linkage Projects
Role Investigator
Funding Start 2008
Funding Finish 2010
GNo G0188386
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Is retirement village living good for health: Comparing the health of older adults living in retirement villages and the community$195,750

Funding body: Central Coast Local Health District

Funding body Central Coast Local Health District
Project Team Associate Professor Martin Veysey, Dr Peter Lewis, Associate Professor Mark Lucock, Doctor Paul Roach, Dr David Kennedy
Scheme Linkage Projects Partner Funding
Role Investigator
Funding Start 2008
Funding Finish 2014
GNo G0188995
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Is retirement village living good for health: Comparing the health of older adults living in retirement villages and the community$85,000

Funding body: UnitingCare Ageing NSW.ACT

Funding body UnitingCare Ageing NSW.ACT
Project Team Associate Professor Martin Veysey, Dr Peter Lewis, Associate Professor Mark Lucock, Doctor Paul Roach, Dr David Kennedy
Scheme Linkage Projects Partner Funding
Role Investigator
Funding Start 2008
Funding Finish 2010
GNo G0189230
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Is retirement village living good for health: Comparing the health of older adults living in retirement villages and the community$15,000

Funding body: Urbis Pty Ltd

Funding body Urbis Pty Ltd
Project Team Associate Professor Martin Veysey, Dr Peter Lewis, Associate Professor Mark Lucock, Doctor Paul Roach, Dr David Kennedy
Scheme Linkage Projects Partner Funding
Role Investigator
Funding Start 2008
Funding Finish 2010
GNo G0189232
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

20073 grants / $55,088

The role of folic acid nutritional genetics in common chronic degenerative disorders$29,424

Funding body: Central Coast Local Health District

Funding body Central Coast Local Health District
Project Team Associate Professor Mark Lucock, Mrs Lyndell Boyd
Scheme Research Sponsorship Scholarship
Role Lead
Funding Start 2007
Funding Finish 2009
GNo G0187843
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Bitter taste phenotype, dietary pattern and nutritional genetics in the aetiopathology of human colonic adenoma/cancer$15,000

AI on UoN Pilot Grant

Funding body: Faculty of Science and IT, University of Newcastle

Funding body Faculty of Science and IT, University of Newcastle
Project Team

Zoe Yates, Mark Lucock

Scheme UoN Pilot Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo
Type Of Funding Internal
Category INTE
UON N

Maternal probiotic treatment protects against colonic and immune dysfunctions induced by neonatal stress$10,664

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Deborah Hodgson, Doctor Michelle Adams, Associate Professor Mark Lucock
Scheme Pilot Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187857
Type Of Funding Internal
Category INTE
UON Y

20053 grants / $50,044

2005 RIBG allocation$31,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Mark Lucock
Scheme Research Infrastructure Block Grant (RIBG)
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0185844
Type Of Funding Internal
Category INTE
UON Y

Vitamin B12 and Autism$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Michelle Adams, Associate Professor Mark Lucock
Scheme Project Grant
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0184636
Type Of Funding Internal
Category INTE
UON Y

Central Coast Vascular Health in Retirement Village Residents Study, Phase 1$9,044

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Martin Veysey, Associate Professor Mark Lucock
Scheme Project Grant
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0184680
Type Of Funding Internal
Category INTE
UON Y

20048 grants / $177,316

PhD - Physio-chemical properties and genetic factors that influence folic acid bioavailability and metabolism: Implications in health and disease$66,084

Funding body: Central Coast Health Teaching & Research Unit

Funding body Central Coast Health Teaching & Research Unit
Project Team Associate Professor Mark Lucock, Miss Xiaowei Ng
Scheme Postgraduate Research Scholarship
Role Lead
Funding Start 2004
Funding Finish 2007
GNo G0184604
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

B-vitamin nutrigenomics in risk for, and progression of, dementia-Pfizer Neuroscience Grant$44,000

Pfizer neuroscience research grant funded a BioRad real time PCR machine

Funding body: Pfizer

Funding body Pfizer
Project Team

Jonathan Sturm, Martin Veysey, Mark Lucock

Scheme Pfizer Neuroscience Research Grant
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON N

Centrifugal Evaporator and Solid Phase Vacuum Manifold System$20,534

Funding body: Faculty of Science and Information Technology, The University of Newcastle | Australia

Funding body Faculty of Science and Information Technology, The University of Newcastle | Australia
Scheme Faculty Large Equipment Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo
Type Of Funding Internal
Category INTE
UON N

Vitamin B12 and gene interactions in autism$20,000

Funding body: Hunter Children`s Research Foundation

Funding body Hunter Children`s Research Foundation
Project Team Doctor Michelle Adams, Associate Professor Mark Lucock, Conjoint Associate Professor John Stuart
Scheme Research Grant
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0184142
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Equipment Funding for a Leica Inverted Microscope$10,000

Funding body: Faculty of Science and Information Technology, University of Newcastle

Funding body Faculty of Science and Information Technology, University of Newcastle
Scheme Small Research Grants
Role Lead
Funding Start 2004
Funding Finish 2004
GNo
Type Of Funding Internal
Category INTE
UON N

Equipment Grant for Bio-Tek Absorbance Microplate Reader$9,164

IGS Funding for a microplate reader

Funding body: Faculty of Science and IT, University of Newcastle

Funding body Faculty of Science and IT, University of Newcastle
Scheme Strategic Small Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo
Type Of Funding Internal
Category INTE
UON N

Salary for Vitamin B12 and Autism Study$5,000

Salary for a Research Assistant

Funding body: Faculty of Science and IT, University of Newcastle

Funding body Faculty of Science and IT, University of Newcastle
Project Team

Dr Michelle Adams, Mark Lucock

Scheme Funded through the School of Applied Sciences
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo
Type Of Funding Internal
Category INTE
UON N

Equipment Grant-RIB for Microfuge$2,534

RIB Grant to purchase a Microfuge

Funding body: University of Newcastle

Funding body University of Newcastle
Scheme RIB Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo
Type Of Funding Internal
Category INTE
UON N

20035 grants / $58,078

3 months salary for research assistant$15,000

Salary for visiting research scholar

Funding body: Faculty of Science and Information Technology, University of Newcastle

Funding body Faculty of Science and Information Technology, University of Newcastle
Project Team

Mark Lucock and Zoe Yates

Scheme Small Research Grants
Role Lead
Funding Start 2003
Funding Finish 2004
GNo
Type Of Funding Internal
Category INTE
UON N

School Start up funds for Nutritional Genetics Study$13,078

Funding body: Faculty of Science and Information Technology, University of Newcastle

Funding body Faculty of Science and Information Technology, University of Newcastle
Project Team

Mark Lucock

Scheme Faculty Strategic Small Grant
Role Lead
Funding Start 2003
Funding Finish 2004
GNo
Type Of Funding Internal
Category INTE
UON N

B-vitamin nutrition and genetics in degenerative and development disorders: A study of nutrient-nutrient, nutrient-gene and gene-gene interactions$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Mark Lucock
Scheme New Staff Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0183548
Type Of Funding Internal
Category INTE
UON Y

Effect of Proton Pump Inhibitors and Genetic Variation on B-Vitamin Bioavailability $10,000

Funding body: Central Coast Health

Funding body Central Coast Health
Project Team

Martin Veysey

Scheme Research Grant
Role Investigator
Funding Start 2003
Funding Finish 2003
GNo
Type Of Funding External
Category EXTE
UON N

B-vitamin nutrition and genetics in degenerative and development disorders: A study of nutrient-nutrient, nutrient-gene and gene-gene interactions$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Scheme New Staff Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo
Type Of Funding Internal
Category INTE
UON N
Edit

Research Supervision

Number of supervisions

Completed12
Current5

Total current UON EFTSL

PhD0.85

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2017 PhD Light Sensitive Vitamins' Relationship with Environmental and Genetic Factors PhD (Food Science), Faculty of Science, The University of Newcastle Principal Supervisor
2017 PhD Determinants of Sour Taste and Consequences for Dietary Habits PhD (Food Science), Faculty of Science, The University of Newcastle Principal Supervisor
2007 PhD The role of folic acid nutritional genetics in common chronic degenerative disorders Food Science & Biotechnology, University of Newcastle Co-Supervisor
2004 PhD Physico-chemical Properties and Genetic Factors that influence the Bioavailability and Metabolism of Folic Acid: Implications in Health and Disease Food Science & Biotechnology, University of Newcastle Principal Supervisor
2003 PhD Investigation of Anti-inflammatory Properties in Dodonaea Species Food Science & Biotechnology, University of Newcastle Co-Supervisor

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2016 PhD Folate and Vitamin D: The Role of Nutritional Status and Nutrigenetics in Predicting Levels of Extracellular microRNA and Circulating DNA Methylation Status PhD (Food Science), Faculty of Science, The University of Newcastle Principal Supervisor
2016 PhD Genotype-Phenotype Relationships Relevant to the Lifecycle with Special Reference to Vitamin Nutrition PhD (Food Science), Faculty of Science, The University of Newcastle Co-Supervisor
2014 PhD The Role of Folic Acid Related Nutritional Genetics in Common Chronic Degenerative Disorders PhD (Food Science), Faculty of Science, The University of Newcastle Principal Supervisor
2014 PhD In Vitro and In Vivo Approaches to the Examination of Folate-Related Nutritional Genetics in Health and Disease PhD (Food Science), Faculty of Science, The University of Newcastle Co-Supervisor
2009 PhD Physico-Chemical Properties and Genetic Factors That Influence the Bioavailability and Metabolism of Folic Acid: Implications in Health and Diseases PhD (Food Science), Faculty of Science, The University of Newcastle Principal Supervisor
2009 PhD Flavonoid Profile and Bioactivity of Dodonaea Viscosa (Australian Hop Bush) - An Indigenous Shrub PhD (Food Science), Faculty of Science, The University of Newcastle Co-Supervisor
2008 PhD The Effect of Temperature Management on the Quality of Broccoli and Table Grapes Exported from Australia PhD (Food Science), Faculty of Science, The University of Newcastle Co-Supervisor
2007 PhD Optimisation Of Polysaccharides from Echinacea Purpurea PhD (Food Science), Faculty of Science, The University of Newcastle Co-Supervisor
2006 Honours THE EFFECT OF NUTRITION AND GENETIC VARIANTS OF VITAMIN B12 METABOLISM ON BIOCHEMICAL AND CLINICAL PHENOTYPE IN AN ELDERLY POPULATION Food Science & Biotechnology, University of Newcastle Co-Supervisor
2006 Honours The effect of temperature on (-)-epigallochatechin gallate, the major catechin in green tea Food Science & Biotechnology, University of Newcastle Co-Supervisor
2005 Honours Does the G80A reduced folate carrier variant alter the cellular level of folate and as a consequence plasma homocysteine, and is this influenced by folate intake Food Prcessing Technology, University of Newcastle Co-Supervisor
2005 Honours Is cognitive function related to plasma thiol disposition in an elderly population Food Science & Biotechnology, University of Newcastle Co-Supervisor
Edit

News

Health Check

Health check: antioxidants vs free radicals

October 9, 2013

Health Check: the untrue story of antioxidants vs free radicals

Associate Professor Mark Lucock

Position

Associate Professor
Human Molecular Nutrition
School of Environmental and Life Sciences
Faculty of Science

Focus area

Applied Sciences

Contact Details

Email mark.lucock@newcastle.edu.au
Phone (02) 4348 4109
Fax (02) 4348 4145

Office

Room E1.25
Building Science Offices.
Location Ourimbah
10 Chittaway Road
Ourimbah, NSW 2258
Australia
Edit