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Professor Marjorie Walker

Professor of Anatomical Pathology

School of Medicine and Public Health (Pathology)

An anatomical pathologists' insight into health

With an intense insight into pathology, Professor Marjorie Walker’s work explores several facets: pathology in the gut in dyspepsia and irritable bowel syndrome, the relationship between brain and gut health in gastroenterology, coeliac disease and also unique biomarkers in prostate cancer.

Professor Marjorie Walker

As an anatomical pathologist, Marjorie is the person who traditionally looks down the microscope and diagnoses biopsies to assess normal, inflammatory or cancerous specimens. This vital role is a buffer between the patient and clinician, dealing directly with doctors rather than patients. Marjorie explains that the role is more of a doctor’s doctor – making a diagnosis that the doctor then explains to the patient.

Studying medicine in the UK at the University of Nottingham, Marjorie took a turn on a fortuitous path to anatomic pathology from general practice. Facing a two month gap between the completion of study and commencing General Practice, and not wanting to be idle, Marjorie approached the pathology department to see if there were any jobs available. Marjorie’s honours year study in pathology led to an appointment as a temporary lecturer; teaching and researching in pathology. “Halfway through the term I thought to myself, ‘I actually really like this’ and realised that I didn’t particularly want to go into General Practice. I wanted to stay looking down the microscope and looking after patients that way. I also really enjoyed the teaching side of academia, which is why I’ve stayed halftime academic and halftime diagnostic pathologist,” Marjorie adds.

Here at the University of Newcastle, Marjorie is co director of the Priority Research Centre for Digestive Health and Neurogastrogenterology with Laureate Professor Nick Talley.

At some point in their lives, roughly twenty to twenty five per cent of Australians will have a functional GI disorder: either irritable bowel disorder or functional dyspepsia or both. Within the Priority Research Centre for Digestive Health and Neurogastroenterology Marjorie and an innovative team of researchers are working hard to look at the pathology behind those conditions.

With a focus on exploring the association with the brain, the team is examining how we can alleviate the symptoms by treating the brain or by treating the gut. However, it’s not just treatment looking to treat and alleviate the symptoms, the aim is to actually resolve the underlying physiology behind the conditions.

Marjorie and the team are looking at gut/brain, brain/gut problems: “We know that there are people who have a functional GI disease who have psychological problems such as anxiety and depression. We also know that sometimes in people who have anxiety and depression they can then develop a GI disorder. So our question is what comes first? Brain/gut or gut/brain?”

A fifty / fifty chance

In looking at the studies, and following people up over an extended period of time, what the team has found is that what comes first is in the region of 50/50. “With fifty per cent of those who have a functional disorder it is preceded by an anxiety disorder and in fifty per cent of those who have an anxiety disorder, it is preceded by a gut disorder,” Marjorie adds.

“With treatment options we know that Cognitive Behavioural Therapy is very effective in some people, particularly those with irritable bowel syndrome. However in those patients, not everybody responds, so what we need to do now is to look to see if those who don’t respond – which way around are they – gut to anxiety or anxiety to gut? That’s work that we’re doing across the country, collaborating with researchers across the east coast,” Marjorie explains.

Marjorie’s primary area of interest is in gastroenterology, looking at functional diseases. “These diseases are called ‘functional’ because they don’t have so-called ‘pathology’ and it’s difficult to understand why people have pain if they don’t have pathology. So we’ve decided to look very carefully at some of the outer reaches of pathology, particularly innate-immunity (such as allergy) and what we found in a large series of studies is that patients with functional GI disease (functional dyspepsia and IBS) have got an innate immune problem which we’re now trying to address with treatment. We have found an asthma like reaction in the duodenum (which connects the stomach to the intestine) in dyspepsia.

The treatment involved is a type of anti-asthma treatment. “We’re doing a trial at the moment where we’re ‘damping down the eosinophils’ (a type of white blood cell) in the duodenum using a slow-release steroid which is really poorly absorbed, so people don’t get steroid side-effects. However, they do get the local effects of the steroid shutting down the eosinophils which is what we think is causing the damage and the pain.” In IBS we have found a bug (colonic spirochaetosis) in a small proportion of those with IBS, which is exciting as these respond to antibiotic treatment.

The work in this PRC will have an enormous impact on the health of our nation. These GI conditions may not be terminal conditions, but they do impact seriously upon people’s life. “Giving people a happier life makes for a happier and more productive nation,” Marjorie concludes.

Looking into biomarkers for prostate cancer

The other side of Marjorie’s research involves looking at biomarkers for prostate cancer, another aspect of anatomical pathology. “The molecular people find clever things such as expression of a protein, and they find that in a lab when they look at levels of protein in a test tube. But what we really need to know is what’s going on in the tissues, so I act as the bridge between the lab and the clinician. So if we look at a piece of tissue, we try to discover how much of this protein is being expressed and in what cells and which disease.”

“I’ve been working with Professor Hubert Hondermarck on a very exciting neurotrophic factor called proNGF which is over-expressed in really bad prostate cancers. We’re now looking at circulating proNGF and we’re looking at expression in a whole range of cancers to see if we can use it as a biomarker to tell whether this is a particularly bad cancer,” Marjorie explains.

One of the problems with prostate cancer is that it’s extremely common – in fact a high proportion of men over 70 will be impacted by prostate cancer. However, some of these cancers are very slow growing, and may not be life-threatening. So how do we know if a cancer’s one to worry about?  “As one of my colleagues at Imperial College, London used to say ‘We need to find the tigers amongst the pussycats’.” Marjorie says.

“What I try to do with prostate cancers is to suss out the tigers, and we think we’ve found a way to do that and we’re currently working on refining the method at the University of Newcastle. We’re making great strides and we’re being recognised as the only people to be working in this field in Australia,” Marjorie concludes.

An international focus

Marjorie is adamant that research is not about being isolated, but is about working in collaboration with people around the country and also internationally.

“With my gastroenterology research we have a nationwide collaboration with the Australian Gastrointestinal Research Alliance (AGIRA), and with Laureate Professor Nick Talley and we collaborate with an array of teams in Sweden, in the US and in Europe - it’s a global connection.”

Marjorie also has an interest in coeliac disease and has produced guidelines in conjunction with other coeliac researchers so that health practitioners have a concerted way of looking at patients and dealing with them. “Guidelines are produced by evidence, and evidence-based medicine is the best way to practice medicine,” Marjorie explains.

For example, helping people living with coeliac make the difficult transition from being an adolescent with coeliac to an adult with coeliac is one area that Marjorie has recently helped to produce guidelines for.

“We’ve also recently completed a large study looking at the prevalence of coeliac disease in the Hunter Valley, and we’re now just trying to unravel what the condition is. One in three Australians do not consume gluten now, which makes diagnosis even more difficult as the duodenum will look normal if a person’s not consuming gluten and deciding if coeliac disease is a true diagnosis really requires a gluten challenge,” Marjorie says.

Professor Marjorie Walker

An anatomical pathologists' insight into health

Professor Walker's expertise as a histopathologist is in interpretation of clinical or molecular events in tissue sections.

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Career Summary

Biography

Research Expertise
My expertise as a histopathologist is in interpretation of clinical or molecular events in tissue sections, correlating both routine pathology and immunocytochemistry to demonstrate particular cells or their function or secretion with clinical patient data. My routine pathology skills lie in Dermatopathology, Urology and Gastrointestinal Pathology. I principally research in gastrointestinal and urological pathology. In Urology I particularly focus on prostate cancer research. My current research in gastrointestinal pathology is focused on finding biomarkers and pathology pathways in functional bowel diseases, named functional as there is no discernible organic pathology. Over the next 5 years I plan to complete the investigation of functional bowel disorders and other gastrointestinal disorders to unravel the pathology which occurs in these diseases, and hope to elucidate the cause of these distressing conditions with the aim of devising effective agents for treatment. I also work on coeliac disease, particularly defining parameters for diagnosis of coeliac disease in conjunction with the International Coeliac Definitions Group.

Teaching Expertise
My teaching experience extends across Undergraduate, Masters and Postgraduate levels. I have taught histopathology to undergraduate and graduate entry students from basic principles to systems pathology. I contribute to course design, exam development and marking – In our curriculum review at the JMP I wish to ensure that students see the integration of pathology into clinical medicine. I have lectured on principles of pathology to wide ranging groups, and I give invited lectures at National and International meetings.

Administrative Expertise
I have extensive administrative experience at University level in teaching and admissions to medicine previously at Imperial College.

Chair of the Admissions committee for the JMP. 

I undertake review of papers for Gut, American Journal of Gastroenterology, Alimentary Pharmacology and Therapeutics, Histopathology, Clinical Gastroenterology and Hepatology, Journal of Clinical Pathology, European Journal of Gastroenterology and Hepatology, Clin Chem Acta, European Journal of Surgical Oncology and the British Journal of Medical and Surgical Urology. I also review grants for CRUK and NHMRC (Australia) and am an Editorial Board member of Alimentary Pharmacology and Therapeutics.

I am a member of the Hunter Cancer Biobank, Flagship (Biomarkers) and Management committees, setting up of new histology facilities, supervising Biobank tissue validation and facilitation of cancer research projects at HMRI.

Collaborations

Our research centre, the Australian GastroIntestinal Research Alliance (AGIRA) is an umbrella for our research in the gut

Functional gastrointestinal disorders (FGIDs) – Biomarkers to avoid costly and uncomfortable investigation, novel pathologies and therapies (Funded by NHMRC grants) with Professor Nick Talley, Professor Gerald Holtmann UQ Brisbane

Inflammatory Bowel Disease (IBD) – targeted therapy, hypoxia as a mechanism – with Dr Simon Keely

Epidemiology studies of scope of GI health in the community, and Coeliac Disease – earlier and robust diagnostic markers, appropriate testing and biopsy interpretation – Professor Nick Talley, Professor John Attia, Dr Mark McEvoy

EoE – novel therapies, molecular studies of mechanisms – Professor Jeorg Mattes, Dr Scott Nightingale, Professor Nick Talley

Brain – Gut /Gut – Brain interaction relation to gut health, interventional CBT, MRI mapping of activity in FGID and other inflammation in the gut. Professor Nick Talley, Professor Gerald Holtmann UQ Brisbane, Dr Natasha Koloski

Microbiome – Use of a unique device to study the role of the upper GI microbiome Professor Gerald Holtmann Brisbane

Australia Nepean Duodenal Eosinophilia study - Pathology in Functional Dyspepsia (FD) in an Australian population - Professor Nick Talley Newcastle University, NSW, and Professor Martin Weltman Nepean Hospital University of Sydney

University of Newcastle - Professor Hubert Hondemarck on nerve- cancer interaction in prostate, breast and pancreatic cancer, review on this topic (Nerve-Cancer Cell Crosstalk: a Novel Promoter of Tumour Progression)

International Collaborations

Sweden - Professor Lars Agréus, Karolinska Institute, Professor Jukka Ronkainen) – Kalixanda and PopCol studies (epidemiology by endoscopy in the upper and lower GI tract) - Eosinophilic Oesophagitis, Coeliac Disease, Biomarkers in Functional Dyspepsia (FD) and Irritable Bowel Syndrome (IBS), Smoking and Allergies and Innate Immunity, Effect of Bile Reflux in the Stomach and Oesophagus, GI hormones in Dyspepsia.

King’s College London – Dr Nick Powell, Immunopathology in the gut

Chile/ Leeds UK - I am an expert advisor to the Content study - funded by the EU, a study on iron deficiency and infection in the gastrointestinal tract in children in Brazil, Chile and London  - Professor Jean Crabtree, Leeds, UK, Dr Paul Harris, Santiago, Chile.

Member of the International Coeliac Definitions Group – an international group of physicians with a prime interest in coeliac disease, defining management and diagnosis of coeliac disease.


Qualifications

  • Bachelor of Medical Science (Honours), University of Nottingham - UK
  • Bachelor of Medicine, Bachelor of Surgery, University of Nottingham - UK

Keywords

  • Coeliac Disease
  • Dermatopathology
  • Functional Bowel Disorders
  • GI Pathology
  • Gastrointestinal Disease
  • Pathology
  • Uropathology

Fields of Research

Code Description Percentage
110316 Pathology (excl. Oral Pathology) 100

Professional Experience

UON Appointment

Title Organisation / Department
Professor of Anatomical Pathology University of Newcastle
School of Medicine and Public Health
Australia

Academic appointment

Dates Title Organisation / Department
1/01/2011 -  Conjoint Associate Professor The University of New South Wales
Australia
1/01/2008 -  Honorary Associate Professor The University of Sydney
Australia
1/01/2005 - 31/12/2022 Membership - European Society of Pathology European Society of Pathology
United Kingdom
1/11/2003 -  Trustee Lymphoma Research Trust
United Kingdom
1/01/2001 - 31/12/2022 Membership - British Society of Gastroenterology (Gastroduodenal Section Committee) British Society of Gastroenterology (Gastroduodenal Section Committee)
United Kingdom
1/01/2000 -  Assistant Admissions Tutor Imperial College London
United Kingdom
1/01/1999 -  Membership - British Society for the Study of Vulval Disease British Society for the Study of Vulval Disease
United Kingdom
1/01/1995 -  Membership - Pathology Society of Great Britain Pathology Society of Great Britain
Australia
1/01/1994 -  Membership - British Society of Dermatopathology British Society of Dermatopathology
United Kingdom
1/01/1989 -  Membership - American Gastroenterology Association American Gastroenterological Association
United States
1/01/1985 -  Membership - British Medical Association British Medical Association
United Kingdom
1/10/1984 - 1/10/2003 Senior Lecturer and Honorary Consultant Imperial College London
United Kingdom
1/01/1982 -  Membership - Association of Clinical Pathologists Association of Clinical Pathologists
Australia
1/02/1981 - 1/09/1984 Senior Registrar Imperial College London
United Kingdom
1/12/1979 - 1/01/1981 Research Assistant (Clinical) and Honorary Registrar Imperial College London
United Kingdom
1/09/1977 - 1/11/1979 Lecturer, Honorary SHO and Honorary Registrar Nottingham University
United Kingdom
1/02/1977 - 1/07/1977 Surgical House Officer General Hospital, Nottingham
United Kingdom
1/08/1976 - 1/01/1977 Medical House Officer General Hospital, Nottingham
United Kingdom

Awards

Recognition

Year Award
2006 Excellence in Teaching Award
Imperial College London

Invitations

Keynote Speaker

Year Title / Rationale
2015 Coeliac Disease: An Underestimated Condition
2014 Lymphocytic Duodenosis
2014 Digestive Disease Week Brazil: The bridge between the pathologist and functional diseases
2014 British Society of Gastroenterology Small bowel and nutrition section – Lymphocytic Duodenosis
2014 Digestive Disease Week Brazil: Irritable Bowel Syndrome: infection, inflammation and the brain-gut axis
2014 Digestive Disease Week Brazil: Current understanding of the pathophysiology of functional GI conditions

Participant

Year Title / Rationale
2006 Gastric phenotype as a predictor of gastric cancer?
Organisation: British Society of Gastroenterology Description:
2006 Is “CLO and go” enough to diagnose H. pylori infection?
Organisation: European Helicobacter Study Group Description: Chair: Pathology and Carcinogenesis Workshop

Speaker

Year Title / Rationale
2012 Coeliac Symposium: What is Lymphocytic Duodenosis?
Organisation: British Society of Gastroenterology Description: Digestive Disease Foundation meeting
2012 Eosinophils and Mast Cells in Functional Gastrointestinal Disorders
Organisation: Nottingham GI Research Group
2011 Organ Defined Eosinophilia
Organisation: West London Rheumatology Group
2010 Infection and Gastrointestinal cancer: mechanisms and therapeutic strategies - Is inflammation essential for pathogen induced carcinogenesis?
Organisation: British Society of Gastroenterology
2010 The Kalixanda Study and GI Eosinophilia.
Organisation: John Hunter Hospital/ Nepean Hospital
2010 Symposium on GI Eosinophilia: Paediatric Eosinophilia
Organisation: European Congress of Pathology
2009 D2? Coeliac – histology or serology for diagnosis?
Organisation: British Society of Gastroenterology
2009 Short course: Gastrointestinal Infections: Upper GI Infections – What else besides Helicobacter pylori?
Organisation: European Congress of Pathology
2008 The Kalixanda Study & Eosinophils in the Upper Gastrointestinal Tract
Organisation: Mayo Clinic
2008 Gastroduodenal Symposium Gastric Lumps and Bumps; How Can Pathology Help?
Organisation: British Society of Gastroenterology
2007 Unusual forms of gastritis: Eosinophilic gastritis
Organisation: European Congress of Pathology
2005 GI infections
Organisation: European Congress of Pathology
2004 Diagnostic Dilemmas in Dysplasia – The Viennese Waltz
Organisation: British Society of Gastroenterology
2004 Gastrointestinal Pathology: Intestinal Metaplasia in the oesophagus and stomach – the clinical value of reporting, classification and follow up.
Organisation: Cellular Pathology Update Study Day
2004 Eosinophilic Gastrointestinal Disease
Organisation: British Society of Allergy and Clinical Immunology
2004 Lectures and slide seminars on gastroduodenal inflammatory pathology
Organisation: European Society of Pathology
2003 Barrett’s Oesophagus – a pathologist’s viewpoint
Organisation: British Oesophageal Group
2003 Endoscopic pathology & Intestinal Metaplasia in the Stomach and Duodenum
Organisation: Oxford GI group
2003 Barrett’s oesophagus
Organisation: Chelsea and Westminster GI group
2003 Current Problems in Gastrointestinal Tract Pathology, Classification of Duodenitis
Organisation: European Congress of Pathology
2001 Reporting Gastritis
Organisation: Association of Clinical Pathologists
2000 Intestinal Metaplasia and Dysplasia in the Stomach, Diagnostic Difficulties and Clinical Consequences
Organisation: International Academy of Pathology
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Book (1 outputs)

Year Citation Altmetrics Link
2000 Walker M, Thursz M, Teare J, Brian F, Upper Gastrointestinal Tract: Ulcers and Inflammation (Practical Endoscopy and Pathology), Wiley-Blackwell, Oxford, United Kingdom, 96 (2000) [A2]

Chapter (2 outputs)

Year Citation Altmetrics Link
2004 Walker M, Talley NJ, 'Duodenitis', Encyclopedia of Gastroenterology, Elsevier, San Diego, United States 653-654 (2004) [B1]
DOI 10.1016/B0-12-386860-2/00199-4
Co-authors Nicholas Talley
1995 Ridley M, Walker M, 'Normal variants of external genital morphology', Genital skin disorders : a guide to non-sexually transmitted conditions, Chapman &? Hall Medical, London, United Kingdom 1-8 (1995) [B1]

Journal article (231 outputs)

Year Citation Altmetrics Link
2017 Marks E, Naudin C, Nolan G, Goggins BJ, Burns G, Mateer SW, et al., 'Regulation of IL-12p40 by HIF controls Th1/Th17 responses to prevent mucosal inflammation', Mucosal Immunology, 10 1224-1236 (2017) [C1]

© 2017 Society for Mucosal Immunology. Intestinal inflammatory lesions are inherently hypoxic, due to increased metabolic demands created by cellular infiltration and proliferati... [more]

© 2017 Society for Mucosal Immunology. Intestinal inflammatory lesions are inherently hypoxic, due to increased metabolic demands created by cellular infiltration and proliferation, and reduced oxygen supply due to vascular damage. Hypoxia stabilizes the transcription factor hypoxia-inducible factor-1a (HIF) leading to a coordinated induction of endogenously protective pathways. We identified IL12B as a HIF-regulated gene and aimed to define how the HIF-IL-12p40 axis influenced intestinal inflammation. Intestinal lamina propria lymphocytes (LPL) were characterized in wild-type and IL-12p40 -/- murine colitis treated with vehicle or HIF-stabilizing prolyl-hydroxylase inhibitors (PHDi). IL12B promoter analysis was performed to examine hypoxia-responsive elements. Immunoblot analysis of murine and human LPL supernatants was performed to characterize the HIF/IL-12p40 signaling axis. We observed selective induction of IL-12p40 following PHDi-treatment, concurrent with suppression of Th1 and Th17 responses in murine colitis models. In the absence of IL-12p40, PHDi-treatment was ineffective. Analysis of the IL12B promoter identified canonical HIF-binding sites. HIF stabilization in LPLs resulted in production of IL-12p40 homodimer which was protective against colitis. The selective induction of IL-12p40 by HIF-1a leads to a suppression of mucosal Th1 an d Th17 responses. This HIF-IL12p40 axis may represent an endogenously protective mechanism to limit the progression of chronic inflammation, shifting from pro-inflammatory IL-12p70 to an antagonistic IL-12p40 homodimer.

DOI 10.1038/mi.2016.135
Co-authors Robert Callister, Martin Veysey, Simon Keely, Paul Foster, Nicholas Talley
2017 Powell N, Walker MM, Talley NJ, 'The mucosal immune system: Master regulator of bidirectional gut-brain communications', Nature Reviews Gastroenterology and Hepatology, 14 143-159 (2017) [C1]

Communication between the brain and gut is not one-way, but a bidirectional highway whereby reciprocal signals between the two organ systems are exchanged to coordinate function. ... [more]

Communication between the brain and gut is not one-way, but a bidirectional highway whereby reciprocal signals between the two organ systems are exchanged to coordinate function. The messengers of this complex dialogue include neural, metabolic, endocrine and immune mediators responsive to diverse environmental cues, including nutrients and components of the intestinal microbiota (microbiota-gut-brain axis). We are now starting to understand how perturbation of these systems affects transition between health and disease. The pathological repercussions of disordered gut-brain dialogue are probably especially pertinent in functional gastrointestinal diseases, including IBS and functional dyspepsia. New insights into these pathways might lead to novel treatment strategies in these common gastrointestinal diseases. In this Review, we consider the role of the immune system as the gatekeeper and master regulator of brain-gut and gut-brain communications. Although adaptive immunity (T cells in particular) participates in this process, there is an emerging role for cells of the innate immune compartment (including innate lymphoid cells and cells of the mononuclear phagocyte system). We will also consider how these key immune cells interact with the specific components of the enteric and central nervous systems, and rapidly respond to environmental variables, including the microbiota, to alter gut homeostasis.

DOI 10.1038/nrgastro.2016.191
Citations Scopus - 3Web of Science - 1
Co-authors Nicholas Talley
2017 Faulkner S, Jobling P, Rowe C, Rodriguez-Oliveira S, Roselli S, Thorne R, et al., 'Neurotrophin Receptors TrkA, p75(NTR), and Sortilin Are Increased and Targetable in Thyroid Cancer.', Am J Pathol, (2017)
DOI 10.1016/j.ajpath.2017.09.008
Co-authors Rick Thorne, Hubert Hondermarck, John Attia, Phillip Jobling, Christopher W Rowe Uon, Christopher Oldmeadow, Xu Zhang, Chenchen Jiang
2017 Farrell KE, Keely S, Walker MM, Brichta AM, Graham BA, Callister RJ, 'Altered intrinsic and synaptic properties of lumbosacral dorsal horn neurons in a mouse model of colitis', Neuroscience, 362 152-167 (2017) [C1]

© 2017 IBRO Visceral pain in inflammatory and functional gastrointestinal conditions is a major clinical problem. The exact mechanisms underlying the development of pain, during ... [more]

© 2017 IBRO Visceral pain in inflammatory and functional gastrointestinal conditions is a major clinical problem. The exact mechanisms underlying the development of pain, during and after visceral inflammation are unknown. However, clinical and pre-clinical evidence suggests plasticity within the spinal cord dorsal horn is a contributing factor. Here we use an in vivo preparation and patch-clamp electrophysiology to test whether the synaptic and intrinsic properties of superficial dorsal horn (SDH) neurons are altered 5 days after the induction of mild colitis in adult male mice (i.e. during acute inflammation of the colon). Whole-cell recordings were made from lumbosacral (L6-S1) superficial dorsal horn neurons (SDH), in animals under isoflurane anesthesia. Noxious colorectal distension (CRD) was used to identify SDH neurons with colonic inputs, while stimulation of the hind paw and tail was employed to assess convergent cutaneous input. Following inflammation, a significantly increased proportion of SDH neurons received both colonic and cutaneous inputs, compared to neurons in naïve animals. In addition, the nature and magnitude of responses to CRD and cutaneous stimulation differed in inflamed animals, as was spontaneous excitatory synaptic drive. Conversely, several measures of intrinsic excitability were altered in a manner that would decrease SDH network excitability following colitis. We propose that during inflammation, sensitization of colonic afferents results in increased signaling to the SDH. This is accompanied by plasticity in SDH neurons whereby their intrinsic properties are changed to compensate for altered afferent activity.

DOI 10.1016/j.neuroscience.2017.08.029
Co-authors Brett Graham, Simon Keely, Robert Callister, Alan Brichta
2017 Marks E, Naudin C, Nolan G, Goggins BJ, Burns G, Mateer SW, et al., 'Regulation of IL-12p40 by HIF controls Th1/Th17 responses to prevent mucosal inflammation', MUCOSAL IMMUNOLOGY, 10 1224-1236 (2017) [C1]
DOI 10.1038/mi.2016.135
Co-authors Martin Veysey, Simon Keely, Nicholas Talley, Paul Foster, Robert Callister
2017 Potter MDE, Brienesse SC, Walker MM, Boyle A, Talley NJ, 'The effect of the gluten free diet on cardiovascular risk factors in patients with coeliac disease: A systematic review.', J Gastroenterol Hepatol, (2017)
DOI 10.1111/jgh.14039
2017 Potter MD, Walker MM, Talley NJ, 'Non-coeliac gluten or wheat sensitivity: emerging disease or misdiagnosis?', The Medical journal of Australia, 207 211-215 (2017) [C1]
Co-authors Nicholas Talley
2017 Talley NJ, Walker MM, 'Celiac Disease and Nonceliac Gluten or Wheat Sensitivity The Risks and Benefits of Diagnosis', JAMA INTERNAL MEDICINE, 177 615-616 (2017)
Citations Scopus - 1Web of Science - 1
Co-authors Nicholas Talley
2017 Le Fevre AK, Walker MM, Hadjiashrafy A, Bhatia R, Mattes J, Talley NJ, Nightingale S, 'Elevated Serum Tissue Transglutaminase Antibodies in Children with Eosinophilic Esophagitis', Journal of Pediatric Gastroenterology and Nutrition, 65 69-74 (2017) [C1]

© Copyright2016 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition... [more]

© Copyright2016 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Objectives: This study compared the clinical and histopathological characteristics of children with eosinophilic esophagitis (EoE) and elevated anti-transglutaminase (TTG Ab) with those with EoE and normal TTG Ab titres. Methods: Single-center chart and blinded histopathological review of patients diagnosed with EoE for a 4-year period, who had esophageal and duodenal biopsies taken at time of endoscopy, and TTG Ab measured within 6 months of biopsy. Patients with histology-proven CD were excluded. Results: Elevated TTG Ab was present in 19/34 (54%) of the study cohort, representing 23% of all patients diagnosed with EoE during the study period. Eight had titers > 6× upper limit of normal (ULN) and 4 had > 10× ULN. TTG Ab-positive patients were classified as having either potential CD with (n=3, 16%) and without lymphocytic duodenosis (LD; n=12, 63%), and no CD (n=4, 21%) on human leukocyte antigen typing. There was an increase in duodenal eosinophils in patients with elevated TTG Ab (P=0.01), which remained when patients with LD were excluded (P=0.018). Of 19 patients with EoE and elevated TTG Ab, 5 responded to elimination diet involving exclusion of wheat, including 2 with a sole wheat trigger and TTG Ab > 10× ULN that were CD-associated human leukocyte antigen-negative. Conclusions: Serum TTG Ab was elevated in almost one-quarter of our total EoE cohort, and at least 20% of these patients did not have potential CD, suggesting EoE is a heterogeneous disease with differing immune mechanisms activated in some patients. These findings also support routine esophageal biopsy during upper endoscopy in children with elevated TTG Ab.

DOI 10.1097/MPG.0000000000001437
Citations Scopus - 2Web of Science - 2
Co-authors Nicholas Talley, Joerg Mattes
2017 Jones MP, Walker MM, Attia JR, 'Understanding statistical principles in correlation, causation and moderation in human disease', Medical Journal of Australia, 207 104-106.e1 (2017) [C1]
DOI 10.5694/mja16.00697
Citations Scopus - 1Web of Science - 1
Co-authors John Attia
2017 Walker MM, Talley NJ, 'The Role of Duodenal Inflammation in Functional Dyspepsia', Journal of Clinical Gastroenterology, 51 12-18 (2017) [C1]
DOI 10.1097/MCG.0000000000000740
Citations Scopus - 3Web of Science - 3
Co-authors Nicholas Talley
2017 Wauters L, Nightingale S, Jones M, Talley NJ, Walker MM, 'Letter: functional dyspepsia is associated with duodenal eosinophilia in an Australian paediatric cohort-methodological issues to avoid misinterpretation. Authors' reply', ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 46 388-388 (2017)
DOI 10.1111/apt.14178
Co-authors Nicholas Talley
2017 Wauters L, Nightingale S, Talley NJ, Sulaiman B, Walker MM, 'Functional dyspepsia is associated with duodenal eosinophilia in an Australian paediatric cohort', Alimentary Pharmacology and Therapeutics, 45 1358-1364 (2017) [C1]
DOI 10.1111/apt.14045
Citations Scopus - 4Web of Science - 3
Co-authors Nicholas Talley
2017 Walker MM, Ludvigsson JF, Sanders DS, 'Coeliac disease: review of diagnosis and management', MEDICAL JOURNAL OF AUSTRALIA, 207 173-178 (2017) [C1]
DOI 10.5694/mja16.00788
Citations Web of Science - 1
2017 Duncanson KR, Talley NJ, Walker MM, Burrows TL, 'Food and functional dyspepsia: a systematic review.', J Hum Nutr Diet, (2017)
DOI 10.1111/jhn.12506
Co-authors Tracy Burrows, Nicholas Talley
2017 Walker MM, Ludvigsson JF, Sanders DS, 'Coeliac disease: Review of diagnosis and management', Medical Journal of Australia, 207 173-178 (2017) [C1]

© 2017 AMPCo Pty Ltd. Produced with Elsevier B.V. All rights reserved. Coeliac disease is an immune-mediated systemic disease triggered by exposure to gluten, and manifested by s... [more]

© 2017 AMPCo Pty Ltd. Produced with Elsevier B.V. All rights reserved. Coeliac disease is an immune-mediated systemic disease triggered by exposure to gluten, and manifested by small intestinal enteropathy and gastrointestinal and extra-intestinal symptoms. Recent guidelines recommend a concerted use of clear definitions of the disease. · In Australia, the most recent estimated prevalence is 1.2% in adult men (1:86) and 1.9% in adult women (1:52). Active case finding is appropriate to diagnose coeliac disease in high risk groups. Diagnosis of coeliac disease is important to prevent nutritional deficiency and long term risk of gastrointestinal malignancy. · The diagnosis of coeliac disease depends on clinico-pathological correlation: history, presence of antitransglutaminase antibodies, and characteristic histological features on duodenal biopsy (when the patient is on a gluten-containing diet). Human leucocyte antigen class II haplotypes DQ2 or DQ8 are found in nearly all patients with coeliac disease, but are highly prevalent in the general population at large (56% in Australia) and testing can only exclude coeliac disease for individuals with non-permissive haplotypes. · Adhering to a gluten free diet allows duodenal mucosal healing and alleviates symptoms. Patients should be followed up with a yearly review of dietary adherence and a health check. · Non-coeliac gluten or wheat protein sensitivity is a syndrome characterised by both gastrointestinal and extra-intestinal symptoms related to the ingestion of gluten and possibly other wheat proteins in people who do not have coeliac disease or wheat allergy recognised by diagnostic tests.

DOI 10.5694m/ja16.00788
Citations Scopus - 1
2017 Zhong L, Shanahan ER, Raj A, Koloski NA, Fletcher L, Morrison M, et al., 'Dyspepsia and the microbiome: time to focus on the small intestine', GUT, 66 1168-+ (2017)
DOI 10.1136/gutjnl-2016-312574
Citations Scopus - 3Web of Science - 4
Co-authors Nicholas Talley
2017 Shah A, Talley NJ, Walker M, Koloski N, Morrison M, Burger D, et al., 'Is There a Link Between H. Pylori and the Epidemiology of Crohn¿s Disease?', Digestive Diseases and Sciences, 62 2472-2480 (2017) [C1]
DOI 10.1007/s10620-017-4496-z
Citations Web of Science - 1
Co-authors Nicholas Talley
2017 Le Fevre AK, Walker MM, Hadjiashrafy A, Bhatia R, Mattes J, Talley NJ, Nightingale S, 'Elevated Serum Tissue Transglutaminase Antibodies in Children With Eosinophilic Esophagitis.', Journal of pediatric gastroenterology and nutrition, 65 69-74 (2017) [C1]
DOI 10.1097/mpg.0000000000001437
Co-authors Nicholas Talley, Joerg Mattes
2017 Jones MP, Tack J, Van Oudenhove L, Walker MM, Holtmann G, Koloski NA, Talley NJ, 'Mood and Anxiety Disorders Precede Development of Functional Gastrointestinal Disorders in Patients but Not in the Population', Clinical Gastroenterology and Hepatology, 15 1014-1020.e4 (2017) [C1]
DOI 10.1016/j.cgh.2016.12.032
Citations Scopus - 4
Co-authors Nicholas Talley
2017 Walker MM, Harris AK, 'Pathogenesis of diverticulosis and diverticular disease.', Minerva Gastroenterol Dietol, 63 99-109 (2017)
DOI 10.23736/S1121-421X.16.02360-6
2016 Faulkner S, Roselli S, Demont Y, Pundavela J, Choquet G, Leissner P, et al., 'ProNGF is a potential diagnostic biomarker for thyroid cancer', Oncotarget, 7 28488-28497 (2016) [C1]

The precursor for nerve growth factor (proNGF) is expressed in some cancers but its clinicopathological significance is unclear. The present study aimed to define the clinicopatho... [more]

The precursor for nerve growth factor (proNGF) is expressed in some cancers but its clinicopathological significance is unclear. The present study aimed to define the clinicopathological significance of proNGF in thyroid cancer. ProNGF expression was analysed by immunohistochemistry in two cohorts of cancer versus benign tumors (adenoma) and normal thyroid tissues. In the first cohort (40 thyroid cancers, 40 thyroid adenomas and 80 normal thyroid tissues), proNGF was found overexpressed in cancers compared to adenomas and normal samples (p < 0.0001). The area under the receiver-operating characteristic (ROC) curve was 0.84 (95% CI 0.75-0.93, p < 0.0001) for cancers versus adenomas, and 0.99 (95% CI 0.98-1.00, p < 0.0001) for cancers versus normal tissues. ProNGF overexpression was confirmed in a second cohort (127 cancers of various histological types and 55 normal thyroid tissues) and using a different antibody (p < 0.0001). ProNGF staining intensity was highest in papillary carcinomas compared to other histological types (p < 0.0001) and there was no significant association with age, gender, tumor size, stage and lymph node status. In conclusion, proNGF is increased in thyroid cancer and should be considered as a new potential diagnostic biomarker.

DOI 10.18632/oncotarget.8652
Citations Scopus - 2Web of Science - 1
Co-authors John Attia, Christopher Oldmeadow, Hubert Hondermarck
2016 Hua S, Cook D, Walker MM, Talley NJ, 'Pharmacological treatment of eosinophilic gastrointestinal disorders', Expert Review of Clinical Pharmacology, 9 1195-1209 (2016) [C1]

© 2016 Informa UK Limited, trading as Taylor &amp; Francis Group. Introduction: Eosinophilic gastrointestinal disorders (EGIDs) are increasingly prevalent chronic inflammatory ... [more]

© 2016 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Eosinophilic gastrointestinal disorders (EGIDs) are increasingly prevalent chronic inflammatory diseases characterized by eosinophilic infiltration of the gastrointestinal (GI) tract, in the absence of other known causes of eosinophilia. Areas covered: Clinical management of EGIDs is challenging, as there are currently limited therapeutic options available. The most common EGID is eosinophilic esophagitis (EoE), and rarer forms are eosinophilic gastritis, eosinophilic gastroenteritis, and eosinophilic colitis. Clinical presentation depends on the affected GI site. Recently duodenal eosinophilia has been recognized to commonly be present in patients with functional dyspepsia. This review will provide an overview of the pathogenesis and therapeutic management of EGIDs, with particular focus on the pharmacological strategies for these conditions. Expert commentary: Despite the considerable progress made in understanding the pathogenesis of EGIDs, there is still an urgent need for the development of specific and effective therapeutic approaches. Therapeutic management protocols are required that are based on rigorous clinical investigation in large prospective controlled trials to better understand the risks, benefits and limitations of each therapy. More well-defined and consistent end-points are also required to assess treatment outcomes, as there has been variability between patient reported outcomes, clinical outcomes, and histological outcomes in the studies to date.

DOI 10.1080/17512433.2016.1190268
Citations Scopus - 3Web of Science - 3
Co-authors Susan Hua, Nicholas Talley
2016 Talley NJ, Walker MM, Holtmann G, 'Functional dyspepsia', Current Opinion in Gastroenterology, 32 467-473 (2016) [C1]

© 2016 Wolters Kluwer Health, Inc. All rights reserved. Purpose of review Functional dyspepsia affects 10% of the population. Emerging data are beginning to unravel the pathogene... [more]

© 2016 Wolters Kluwer Health, Inc. All rights reserved. Purpose of review Functional dyspepsia affects 10% of the population. Emerging data are beginning to unravel the pathogenesis of this heterogeneous disorder, and new data on treatment are helping to guide evidencebased practice. In this review, the latest advances are summarized and discussed. Recent findings The Rome IV criteria were published in 2016 and are similar to Rome III but further emphasize the subtypes (postprandial distress syndrome and epigastric pain syndrome) rather than focussing on the syndrome as a whole, and conclude that gastroesophageal reflux disease and irritable bowel syndrome are part of the functional dyspepsia spectrum. Environment is dominant in the pathogenesis. New data implicate herbivore pets and antibiotic exposure for a nongastrointestinal infection but require confirmation. Further experimental data suggest duodenal eosinophils and mast cells can alter enteric neuronal structure and function in functional dyspepsia. Summary Advances in our understanding of functional dyspepsia are changing clinical practice.

DOI 10.1097/MOG.0000000000000306
Citations Scopus - 5Web of Science - 6
Co-authors Nicholas Talley
2016 Walker MM, Keely SJ, Scott RJ, Talley NJ, 'Genetics, Mucosal Inflammation, and the Environment in Post-Infectious Chronic Gut Syndromes', The American Journal of Gastroenterology Supplements, 3 46-51 (2016) [C1]
DOI 10.1038/ajgsup.2016.14
Co-authors Simon Keely, Nicholas Talley, Rodney Scott
2016 Goodsall TM, Talley NJ, Rassam L, Wood NK, Zala A, Jones M, Walker MM, 'Unique pathology of colonic spirochaetosis characterised by mucosal eosinophilia is linked to diarrhoea and IBS', Gut, 66 978-979 (2016)
DOI 10.1136/gutjnl-2016-312405
Citations Scopus - 2Web of Science - 2
Co-authors Nicholas Talley
2016 Witte A-B, Walker MM, Talley NJ, Aro P, Ronkainen J, Marrazzo V, et al., 'Decreased Number of Duodenal Endocrine Cells with Unaltered Serotonin-Containing Cells in Functional Dyspepsia', AMERICAN JOURNAL OF GASTROENTEROLOGY, 111 1852-1853 (2016)
DOI 10.1038/ajg.2016.468
Citations Scopus - 2
Co-authors Nicholas Talley
2016 Ludvigsson JF, Agreus L, Ciacci C, Crowe SE, Geller MG, Green PHR, et al., 'Transition from childhood to adulthood in coeliac disease: The Prague consensus report', Gut, 65 1242-1251 (2016) [C1]

© 2016 Published by the BMJ Publishing Group Limited. The process of transition from childhood to adulthood is characterised by physical, mental and psychosocial development. Dat... [more]

© 2016 Published by the BMJ Publishing Group Limited. The process of transition from childhood to adulthood is characterised by physical, mental and psychosocial development. Data on the transition and transfer of care in adolescents/young adults with coeliac disease (CD) are scarce. In this paper, 17 physicians from 10 countries (Sweden, Italy, the USA, Germany, Norway, the Netherlands, Australia, Britain, Israel and Denmark) and two representatives from patient organisations (Association of European Coeliac Societies and the US Celiac Disease Foundation) examined the literature on transition from childhood to adulthood in CD. Medline (Ovid) and EMBASE were searched between 1900 and September 2015. Evidence in retrieved reports was evaluated using the Grading of Recommendation Assessment, Development and Evaluation method. The current consensus report aims to help healthcare personnel manage CD in the adolescent and young adult and provide optimal care and transition into adult healthcare for patients with this disease. In adolescence, patients with CD should gradually assume exclusive responsibility for their care, although parental support is still important. Dietary adherence and consequences of non-Adherence should be discussed during transition. In most adolescents and young adults, routine small intestinal biopsy is not needed to reconfirm a childhood diagnosis of CD based on European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) or North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) criteria, but a biopsy may be considered where paediatric diagnostic criteria have not been fulfilled, such as, in a patient without biopsy at diagnosis, additional serology (endomysium antibody) has not been performed to confirm 10-fold positivity of tissue transglutaminase antibodies or when a no biopsy strategy has been adopted in an asymptomatic child.

DOI 10.1136/gutjnl-2016-311574
Citations Scopus - 8Web of Science - 7
2016 Walker MM, 'Inflammation, Genetics, Dysbiosis, and the Environment: New Paradigms for Diagnosis in Complex Chronic Gut Syndromes.', J Clin Gastroenterol, 50 Suppl 1 S4-S5 (2016) [C1]
DOI 10.1097/MCG.0000000000000613
2016 Gang L, Hsu A, Cooley MA, Jarnicki AG, Nair PM, Haw TJ, et al., 'Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases', Journal of Clinical Investigation Insight, 1 (2016) [C1]
DOI 10.1172/jci.insight.86380
Citations Web of Science - 10
Co-authors Michael Fricker, Alan Hsu, Philip Hansbro, Darryl Knight, Jay Horvat, Peter Wark
2016 Napthali K, Koloski N, Walker MM, Talley NJ, 'Women and Functional Dyspepsia', WOMENS HEALTH, 12 241-250 (2016) [C1]
DOI 10.2217/whe.15.88
Citations Scopus - 1Web of Science - 1
Co-authors Nicholas Talley
2016 Talley NJ, Walker MM, 'Established and Emerging Eosinophilic Gastrointestinal Diseases (EGIDs): Seeing Red and Looking Ahead', DIGESTIVE DISEASES AND SCIENCES, 61 2453-2455 (2016)
DOI 10.1007/s10620-016-4240-0
Co-authors Nicholas Talley
2016 Walker MM, Harris AK, Edwards GC, Talley NJ, 'A GP primer to understanding biopsy reports of the lower gastrointestinal tract', AUSTRALIAN FAMILY PHYSICIAN, 45 408-413 (2016)
Co-authors Nicholas Talley
2015 Roselli S, Pundavela J, Demont Y, Faulkner S, Keene S, Attia J, et al., 'Sortilin is associated with breast cancer aggressiveness and contributes to tumor cell adhesion and invasion', Oncotarget, 6 10473-10486 (2015) [C1]

The neuronal membrane protein sortilin has been reported in a few cancer cell lines, but its expression and impact in human tumors is unclear. In this study, sortilin was analyzed... [more]

The neuronal membrane protein sortilin has been reported in a few cancer cell lines, but its expression and impact in human tumors is unclear. In this study, sortilin was analyzed by immunohistochemistry in a series of 318 clinically annotated breast cancers and 53 normal breast tissues. Sortilin was detected in epithelial cells, with increased levels in cancers, as compared to normal tissues (p = 0.0088). It was found in 79% of invasive ductal carcinomas and 54% of invasive lobular carcinomas (p < 0.0001). There was an association between sortilin expression and lymph node involvement (p = 0.0093), suggesting a relationship with metastatic potential. In cell culture, sortilin levels were higher in cancer cell lines compared to non-tumorigenic breast epithelial cells and siRNA knockdown of sortilin inhibited cancer cell adhesion, while proliferation and apoptosis were not affected. Breast cancer cell migration and invasion were also inhibited by sortilin knockdown, with a decrease in focal adhesion kinase and SRC phosphorylation. In conclusion, sortilin participates in breast tumor aggressiveness and may constitute a new therapeutic target against tumor cell invasion.

Citations Scopus - 6Web of Science - 6
Co-authors Hubert Hondermarck, Xu Zhang, Chenchen Jiang, John Attia
2015 Collison AM, Sokulsky LA, Sherrill JD, Nightingale S, Hatchwell L, Talley NJ, et al., 'TNF-related apoptosis-inducing ligand (TRAIL) regulates midline-1, thymic stromal lymphopoietin, inflammation, and remodeling in experimental eosinophilic esophagitis', Journal of Allergy and Clinical Immunology, 136 971-982 (2015) [C1]

© 2015 American Academy of Allergy, Asthma &amp; Immunology. Background Eosinophilic esophagitis (EoE) is an inflammatory disorder of the esophagus defined by eosinophil infilt... [more]

© 2015 American Academy of Allergy, Asthma & Immunology. Background Eosinophilic esophagitis (EoE) is an inflammatory disorder of the esophagus defined by eosinophil infiltration and tissue remodeling with resulting symptoms of esophageal dysfunction. TNF-related apoptosis-inducing ligand (TRAIL) promotes inflammation through upregulation of the E3 ubiquitin-ligase midline-1 (MID1), which binds to and deactivates the catalytic subunit of protein phosphatase 2Ac, resulting in increased nuclear factor ¿B activation. Objective We sought to elucidate the role of TRAIL in EoE. Methods We used Aspergillus fumigatus to induce EoE in TRAIL-sufficient (wild-type) and TRAIL-deficient (TRAIL -/- ) mice and targeted MID1 in the esophagus with small interfering RNA. We also treated mice with recombinant thymic stromal lymphopoietin (TSLP) and TRAIL. Results TRAIL deficiency and MID1 silencing with small interfering RNA reduced esophageal eosinophil and mast cell numbers and protected against esophageal circumference enlargement, muscularis externa thickening, and collagen deposition. MID1 expression and nuclear factor ¿B activation were reduced in TRAIL -/- mice, whereas protein phosphatase 2Ac levels were increased compared with those seen in wild-type control mice. This was associated with reduced expression of CCL24, CCL11, CCL20, IL-5, IL-13, IL-25, TGFB, and TSLP. Treatment with TSLP reconstituted hallmark features of EoE in TRAIL -/- mice and recombinant TRAIL induced esophageal TSLP expression in vivo in the absence of allergen. Post hoc analysis of gene array data demonstrated significant upregulation of TRAIL and MID1 in a cohort of children with EoE compared with that seen in controls. Conclusion TRAIL regulates MID1 and TSLP, inflammation, fibrosis, smooth muscle hypertrophy, and expression of inflammatory effector chemokines and cytokines in experimental EoE.

DOI 10.1016/j.jaci.2015.03.031
Citations Scopus - 4Web of Science - 3
Co-authors Joerg Mattes, Nicholas Talley, Adam Collison
2015 Talley NJ, Holtmann G, Walker MM, 'Therapeutic strategies for functional dyspepsia and irritable bowel syndrome based on pathophysiology', Journal of Gastroenterology, 50 601-613 (2015) [C1]

© 2015, Springer Japan. Functional gastrointestinal disorders (FGIDs) are common and distressing. They are so named because a defined pathophysiology in terms of structural or bi... [more]

© 2015, Springer Japan. Functional gastrointestinal disorders (FGIDs) are common and distressing. They are so named because a defined pathophysiology in terms of structural or biochemical pathways is lacking. Traditionally FGIDs have been conceptualized as brain¿gut disorders, with subgroups of patients demonstrating visceral hypersensitivity and motility abnormalities as well as psychological distress. However, it is becoming apparent that there are certain structural or biochemical gut alterations among subsets with the common FGIDs, most notably functional dyspepsia (FD) and irritable bowel syndrome (IBS). For example, a sodium channel mutation has been identified in IBS that may account for 2¿% of cases, and subtle intestinal inflammation has been observed in both IBS and FD. Other research has implicated early life events and stress, autoimmune disorders and atopy and infections, the gut microbiome and disordered mucosal immune activation in patients with IBS or FD. Understanding the origin of symptoms in FGIDs will allow therapy to be targeted at the pathophysiological changes, not at merely alleviating symptoms, and holds hope for eventual cure in some cases. For example, there are promising developments in manipulating the microbiome through diet, prebiotics and antibiotics in IBS, and testing and treating patients for Helicobacter pylori infection remains a mainstay of therapy in patients with dyspepsia and this infection. Locally acting drugs such as linaclotide have been an advance in treating the symptoms of constipation-predominant IBS, but do not alter the natural history of the disease. A role for a holistic approach to patients with FGIDs is warranted, as brain-to-gut and gut-to-brain pathways appear to be activated.

DOI 10.1007/s00535-015-1076-x
Citations Scopus - 17Web of Science - 13
Co-authors Nicholas Talley
2015 Walker MM, Talley NJ, Inganäs L, Engstrand L, Jones MP, Nyhlin H, et al., 'Colonic spirochetosis is associated with colonic eosinophilia and irritable bowel syndrome in a general population in Sweden', Human Pathology, 46 277-283 (2015) [C1]

Irritable bowel syndrome (IBS) is a functional disorder defined by symptoms in the absence of overt pathology. Colonic spirochetosis (CS), defined by histologic observation of spi... [more]

Irritable bowel syndrome (IBS) is a functional disorder defined by symptoms in the absence of overt pathology. Colonic spirochetosis (CS), defined by histologic observation of spirochetal strains of Brachyspira in colonic biopsies, is uncommon and considered of doubtful significance. We aimed to determine the prevalence of CS in the general population, identify subtle colon pathologies, and evaluate a link with symptoms of IBS. Colonoscopy was performed in 745 subjects (aged 19-70 years, mean age 51 years, 43% male) with biopsies (ileum and 4 colonic sites) from a random population sample, Stockholm, Sweden, who completed a validated questionnaire of gastrointestinal symptoms; IBS was identified by Rome III criteria. CS was identified by histology and immunohistochemistry. In a general population, 17 individuals (2.28%; 95% confidence interval, 1.2%-3.5%) were diagnosed as having CS by histology; 6 (35%) had IBS. CS was always present in the sigmoid colon, but only 14 rectal biopsies. Eosinophils were increased in colon biopsies in CS cases versus controls, in the transverse (P =.02), sigmoid colon (P =.001), and rectum (P =.0005) with subepithelial eosinophil clusters (P =.053). Lymphoid follicles (at any site) were present in 13 CS (P =.0003). There was a 3-fold increased risk of IBS in CS (odds ratio, 3.59; 95% confidence interval, 1.27-10.11; P =.015). Polyps and diverticular disease were similar in CS cases and controls. The prevalence of CS in a general population is 2% and associated with nonconstipating IBS. Colonic eosinophilia with lymphoid follicles may signify the presence of CS.

DOI 10.1016/j.humpath.2014.10.026
Citations Scopus - 13Web of Science - 12
Co-authors Nicholas Talley
2015 Jobling P, Pundavela J, Oliveira SMR, Roselli S, Walker MM, Hondermarck H, 'Nerve-Cancer Cell Cross-talk: A Novel Promoter of Tumor Progression', CANCER RESEARCH, 75 1777-1781 (2015) [C1]
DOI 10.1158/0008-5472.CAN-14-3180
Citations Scopus - 25Web of Science - 24
Co-authors Phillip Jobling, Hubert Hondermarck
2015 Pundavela J, Roselli S, Faulkner S, Attia J, Scott RJ, Thorne RF, et al., 'Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer', Molecular Oncology, 9 1626-1635 (2015) [C1]
DOI 10.1016/j.molonc.2015.05.001
Citations Scopus - 5Web of Science - 4
Co-authors Phillip Jobling, John Forbes, Rick Thorne, Rodney Scott, Hubert Hondermarck, John Attia
2015 Zala AV, Walker MM, Talley NJ, 'Emerging drugs for functional dyspepsia', Expert Opinion on Emerging Drugs, 20 221-233 (2015) [C1]

© 2015 Informa UK, Ltd. Introduction: Functional dyspepsia (FD) is a relatively common gastrointestinal clinical condition that remains poorly understood. Controversies remain re... [more]

© 2015 Informa UK, Ltd. Introduction: Functional dyspepsia (FD) is a relatively common gastrointestinal clinical condition that remains poorly understood. Controversies remain regarding the definition, pathophysiology and optimum treatment the current treatment of FD is limited and no established regimen is available.Areas covered: Recent advances have improved our understanding of the pathophysiology of the disease and have led to the development of newer tailored therapies. Novel agents such as the motilin receptor agonist camicinal and the muscarinic M1 and M2 receptor antagonist acotiamide appear promising; however, the need for a safe and efficacious treatment remains largely unmet. This review describes the currently available management options for FD and critically evaluates emerging therapies.Expert opinion: The optimal treatment for FD is yet to be determined. A proton pump inhibitor or a prokinetic agent constitutes primary treatment. Helicobacter pylori testing and eradication is recommended. Based on currently available data, acotiamide appears promising, particularly in postprandial distress syndrome. Further large-scale multicentered trials are required to define the duration of treatment and the side-effect profile.

DOI 10.1517/14728214.2015.1009827
Citations Scopus - 12Web of Science - 9
Co-authors Nicholas Talley
2015 Keely S, Walker MM, Marks E, Talley NJ, 'Immune dysregulation in the functional gastrointestinal disorders', European Journal of Clinical Investigation, 45 1350-1359 (2015) [C1]
DOI 10.1111/eci.12548
Citations Scopus - 14Web of Science - 12
Co-authors Simon Keely, Nicholas Talley
2015 Koloski NA, Jones M, Weltman M, Kalantar J, Bone C, Gowryshankar A, et al., 'Identification of early environmental risk factors for irritable bowel syndrome and dyspepsia', Neurogastroenterology and Motility, 27 1317-1325 (2015) [C1]

© 2015 John Wiley &amp; Sons Ltd. Background: The role of childhood environment including exposure to infection via siblings and pets in irritable bowel syndrome (IBS) and dysp... [more]

© 2015 John Wiley & Sons Ltd. Background: The role of childhood environment including exposure to infection via siblings and pets in irritable bowel syndrome (IBS) and dyspepsia is relatively unknown. We assessed proxy measures of microbial exposure in early childhood to assess if these are associated with IBS and functional dyspepsia in later life. Methods: Participants (n¿=¿767, response rate¿=¿53%) were a random population sample from Sydney, Australia who previously responded to a validated survey. IBS and functional dyspepsia were defined using Rome III criteria. Early environmental risk factors assessed included type of birth delivery, premature birth, breastfeeding, bedroom sharing, and pet exposure (the latter two then combined as early hygiene factors) up to 5¿years of age. Post infectious IBS (PI-IBS) was assessed by development of IBS following gastroenteritis. Key Results: In this sample, in adult life 17% developed IBS (of which 20% had PI-IBS) and 12% functional dyspepsia. Development of IBS was associated with childhood factors-a shorter duration of breastfeeding (odds ratios [OR]¿=¿0.87, 95% CI: 0.78-0.97, p¿=¿0.01), sharing a bedroom (OR¿=¿1.89, 95% CI: 1.73-3.08, p¿=¿0.01), exposure to a herbivore pet (OR¿=¿1.65 (1.10, 2.48), p¿=¿0.02), and hygiene factors (OR¿=¿4.39; 95% CI: 1.89-10.21, p¿=¿0.001). The sole factor associated with functional dyspepsia was exposure to a herbivore pet (1.79; 95% CI: 1.19-2.87, p¿=¿0.02). Conclusions & Inferences: Childhood environment factors, particularly bedroom sharing and pet exposure, combined with subsequent risk of microbial exposure are a risk factor for IBS in later life. These associations however need confirmation to rule out any risk of a type I error.

DOI 10.1111/nmo.12626
Citations Scopus - 11Web of Science - 11
Co-authors Nicholas Talley
2015 Keely S, Veysey M, Walker MM, Talley NJ, 'Letter: oxidative stress, cause or consequence of constipation-associated colorectal cancer?', Aliment Pharmacol Ther, 42 941-942 (2015) [C3]
DOI 10.1111/apt.13349
Co-authors Simon Keely, Martin Veysey, Nicholas Talley
2015 Walker MM, 'Histopathology diagnosis of coeliac disease - Clinicopathological correlation is key!', Gastroenterology and Hepatology from Bed to Bench, 8 309-310 (2015) [C3]
Citations Scopus - 3
2015 Marks E, Goggins BJ, Cardona J, Cole S, Minahan K, Mateer S, et al., 'Oral Delivery of Prolyl Hydroxylase Inhibitor: AKB-4924 Promotes Localized Mucosal Healing in a Mouse Model of Colitis.', Inflammatory bowel diseases, 21 267-275 (2015) [C1]
DOI 10.1097/mib.0000000000000277
Citations Scopus - 9Web of Science - 8
Co-authors Simon Keely
2015 Walker MM, Harris AK, Edwards GC, Talley NJ, 'A GP primer for understanding upper gastrointestinal tract biopsy reports', AUSTRALIAN FAMILY PHYSICIAN, 44 706-711 (2015) [C1]
Citations Web of Science - 2
Co-authors Nicholas Talley
2014 Pundavela J, Demont Y, Jobling P, Lincz LF, Roselli S, Thorne RF, et al., 'ProNGF correlates with Gleason score and is a potential driver of nerve infiltration in prostate cancer', American Journal of Pathology, 184 3156-3162 (2014) [C1]

© 2014 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved. Nerve infiltration is essential to prostate cancer progression, but the mecha... [more]

© 2014 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved. Nerve infiltration is essential to prostate cancer progression, but the mechanism by which nerves are attracted to prostate tumors remains unknown. We report that the precursor of nerve growth factor (proNGF) is overexpressed in prostate cancer and involved in the ability of prostate cancer cells to induce axonogenesis. A series of 120 prostate cancer and benign prostate hyperplasia (BPH) samples were analyzed by IHC for proNGF. ProNGF was mainly localized in the cytoplasm of epithelial cells, with marked expression in cancer compared with BPH. Importantly, the proNGF level positively correlated with the Gleason score (n = 104, t < inf > B < /inf > = 0.51). A higher level of proNGF was observed in tumors with a Gleason score of =8 compared with a Gleason score of 7 and 6 (P < 0.001). In vitro, proNGF was detected in LNCaP, DU145, and PC-3 prostate cancer cells and BPH-1 cells but not in RWPE-1 immortalized nontumorigenic prostate epithelial cells or primary normal prostate epithelial cells. Co-culture of PC12 neuronal-like cells or 50B11 neurons with PC-3 cells resulted in neurite outgrowth in neuronal cells that was inhibited by blocking antibodies against proNGF, indicating that prostate cancer cells can induce axonogenesis via secretion of proNGF. These data reveal that ProNGF is a biomarker associated with high-risk prostate cancers and a potential driver of infiltration by nerves.

DOI 10.1016/j.ajpath.2014.08.009
Citations Scopus - 9Web of Science - 6
Co-authors Phillip Jobling, Rick Thorne, Hubert Hondermarck, Danielle Bond, Lisa Lincz
2014 Ludvigsson JF, Bai JC, Biagi F, Card TR, Ciacci C, Ciclitira PJ, et al., 'Diagnosis and management of adult coeliac disease: Guidelines from the British society of gastroenterology', Gut, 63 1210-1228 (2014) [C1]

A multidisciplinary panel of 18 physicians and 3 nonphysicians from eight countries (Sweden, UK, Argentina, Australia, Italy, Finland, Norway and the USA) reviewed the literature ... [more]

A multidisciplinary panel of 18 physicians and 3 nonphysicians from eight countries (Sweden, UK, Argentina, Australia, Italy, Finland, Norway and the USA) reviewed the literature on diagnosis and management of adult coeliac disease (CD). This paper presents the recommendations of the British Society of Gastroenterology. Areas of controversies were explored through phone meetings and web surveys. Nine working groups examined the following areas of CD diagnosis and management: classification of CD; genetics and immunology; diagnostics; serology and endoscopy; follow-up; gluten-free diet; refractory CD and malignancies; quality of life; novel treatments; patient support; and screening for CD.

DOI 10.1136/gutjnl-2013-306578
Citations Scopus - 215Web of Science - 195
2014 Ford AC, Talley NJ, Walker MM, Jones MP, 'Increased prevalence of autoimmune diseases in functional gastrointestinal disorders: case-control study of 23 471 primary care patients', ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 40 827-834 (2014) [C1]
DOI 10.1111/apt.12903
Citations Scopus - 6Web of Science - 5
Co-authors Nicholas Talley
2014 Walker MM, Talley NJ, 'Review article: Bacteria and pathogenesis of disease in the upper gastrointestinal tract - Beyond the era of Helicobacter pylori', Alimentary Pharmacology and Therapeutics, 39 767-779 (2014) [C1]

Background Study of the upper gastrointestinal microbiome has shown that other bacteria besides Helicobacter pylori flourish despite the hostile environment. Whilst H. pylori is ... [more]

Background Study of the upper gastrointestinal microbiome has shown that other bacteria besides Helicobacter pylori flourish despite the hostile environment. Whilst H. pylori is the most studied bacteria in this region with a defined role in inflammation and neoplasia, it is apparent that other bacteria may contribute to UGI disease. Aim To review current knowledge of bacteria inhabiting the oesophagus, stomach and duodenum. Methods Published studies on the upper gastrointestinal microbiome (extracted from PubMed during the last 20 years). Results The stomach is a hostile environment for bacteria; however, recent studies categorising the microbiota have shown surprising results. Helicobacter pylori has been intensively studied since 1984 and recent sequencing analysis of other gastric microbiota shows that H. pylori is not alone. Composition can be influenced by acid suppression, gastritis and abundance of H. pylori. Eradication of H. pylori, whilst decreasing gastric cancer is associated with an increase in asthma, reflux and obesity. A future approach may be to selectively eradicate bacteria which predispose to inflammation and cancer as opposed to a comprehensive knockout policy. In the oesophagus, viridans streptococci are the most common bacteria influenced by both oral and gastric bacteria. Oesophagitis and Barrett's oesophagus are characterised by a significant decrease in Gram-positive bacteria and an increase in Gram-negative bacteria. An inverse association of H. pylori and oesophageal adenocarcinoma is described. The duodenal microbiome has been shown to influence small intestinal bacterial overgrowth, irritable bowel syndrome and coeliac disease. The numbers of bacteria recoverable by culture are variable in the stomach mucosa and gastric juice, typically 10 2 -10 4 colony-forming units (CFU)/g or mL and in the oesophagus, up to 10 4 bacteria per mm 2 mucosal surface. In the small bowel, in health, 10 3 CFU/mL are normal. Conclusion This review highlights current knowledge of upper gastrointestinal bacteria and associations with disease. © 2014 John Wiley & Sons Ltd.

DOI 10.1111/apt.12666
Citations Scopus - 38Web of Science - 36
Co-authors Nicholas Talley
2014 Walker MM, Harris Diez PR, Crabtree JE, 'Commentary: Duodenal intraepithelial lymphocytosis in children without coeliac disease', Alimentary Pharmacology and Therapeutics, 39 1430-1431 (2014) [C3]
DOI 10.1111/apt.12779
Citations Scopus - 1Web of Science - 1
2014 Walker MM, Aggarwal KR, Shim LSE, Bassan M, Kalantar JS, Weltman MD, et al., 'Duodenal eosinophilia and early satiety in functional dyspepsia: Confirmation of a positive association in an Australian cohort', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 29 474-479 (2014) [C1]
DOI 10.1111/jgh.12419
Citations Scopus - 35Web of Science - 32
Co-authors Nicholas Talley
2014 Jones MP, Walker MM, Ford AC, Talley NJ, 'Editorial: The overlap of atopy and functional gastrointestinal disorders in primary care - Authors' reply', Alimentary Pharmacology and Therapeutics, 40 1244-1245 (2014) [C3]
DOI 10.1111/apt.12961
Co-authors Nicholas Talley
2014 Jones MP, Walker MM, Ford AC, Talley NJ, 'The overlap of atopy and functional gastrointestinal disorders among 23 471 patients in primary care', Alimentary Pharmacology and Therapeutics, 40 382-391 (2014) [C1]

Background Activation of the immune system has been demonstrated in atopy and functional gastrointestinal disorders (FGIDs). Previous data from our group have suggested a connecti... [more]

Background Activation of the immune system has been demonstrated in atopy and functional gastrointestinal disorders (FGIDs). Previous data from our group have suggested a connection between immune dysregulation, FGIDs and mood disorders. Aim To investigate if these data translate to clinical practice and examine connections from the perspective of FGIDs to determine whether atopy and FGIDs are connected via mood disorders. Methods Evidence of irritable bowel syndrome (IBS), functional dyspepsia (FD) and constipation was sought from the medical records of 30 000 primary care records over a minimum 5 year period. The same records yielded diagnoses of four atopic conditions (asthma, eczema, allergic rhinitis/hay fever and conjunctivitis). Results Atopic conditions were found in excess among all FGID groups considered when compared with controls. In the groups with IBS alone (OR = 1.43, 1.29-1.58), FD alone (OR = 1.41, 1.26-1.58) and those with multiple FGIDs (OR = 1.92, 1.75-2.12) there was elevated prevalence of asthma compared with controls without a FGID. Across disorders the excess was generally highest among patients diagnosed with multiple FGIDs (rhinitis/hay fever OR = 3.74, 3.32-4.20; conjunctivitis OR = 3.00, 2.49-3.62) and was only partly explained by a common association between both FGIDs and atopic conditions with mood disorders, although not for every atopic/FGID combination (rhinitis/hay fever OR = 2.60, 2.29-2.96, conjunctivitis OR = 2.34, 1.90-2.87). Conclusions Irritable bowel syndrome, functional dyspepsia and constipation share an association with atopy that is only partly explained via a common connection with mood disorders. These data have important implications for understanding both the pathophysiology of functional gastrointestinal disorders and development of new treatments. © 2014 John Wiley & Sons Ltd.

DOI 10.1111/apt.12846
Citations Scopus - 24Web of Science - 22
Co-authors Nicholas Talley
2014 Walker MM, Powell N, Talley NJ, 'Atopy and the gastrointestinal tract--a review of a common association in unexplained gastrointestinal disease.', Expert Rev Gastroenterol Hepatol, 8 289-299 (2014) [C1]
DOI 10.1586/17474124.2014.881716
Citations Scopus - 19Web of Science - 16
Co-authors Nicholas Talley
2013 Talley NJ, Walker MM, 'Novel insights into the pathology of upper gut symptoms: new syndromes, new diseases.', Med J Aust, 199 440-441 (2013) [C3]
Citations Web of Science - 2
Co-authors Nicholas Talley
2013 Low LCM, Kinderlerer A, Walker MM, Setterfield J, 'A woman with asthma and hemorrhagic bullae', INTERNATIONAL JOURNAL OF DERMATOLOGY, 52 793-794 (2013) [C3]
DOI 10.1111/j.1365-4632.2012.05837.x
Citations Scopus - 2Web of Science - 2
2013 Romero D, Kawano Y, Bengoa N, Walker MM, Maltry N, Niehrs C, et al., 'Downregulation of Dickkopf-3 disrupts prostate acinar morphogenesis through TGF-beta/Smad signalling', JOURNAL OF CELL SCIENCE, 126 1858-1867 (2013) [C1]
DOI 10.1242/jcs.119388
Citations Scopus - 14Web of Science - 14
2013 Harris PR, Serrano CA, Villagran A, Walker MM, Thomson M, Duarte I, et al., 'Helicobacter pylori-associated hypochlorhydria in children, and development of iron deficiency', JOURNAL OF CLINICAL PATHOLOGY, 66 343-347 (2013) [C1]
DOI 10.1136/jclinpath-2012-201243
Citations Scopus - 21Web of Science - 18
2013 Ludvigsson JF, Aro P, Walker MM, Vieth M, Agreus L, Talley NJ, et al., 'Celiac disease, eosinophilic esophagitis and gastroesophageal reflux disease, an adult population-based study', SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 48 808-814 (2013) [C1]
DOI 10.3109/00365521.2013.792389
Citations Scopus - 26Web of Science - 24
Co-authors Nicholas Talley
2013 Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PHR, et al., 'The Oslo definitions for coeliac disease and related terms', Gut, 62 43-52 (2013) [C1]
DOI 10.1136/gutjnl-2011-301346
Citations Scopus - 510Web of Science - 430
2013 Magalhaes Queiroz DM, Harris PR, Sanderson IR, Windle HJ, Walker MM, Camargos Rocha AM, et al., 'Iron Status and Helicobacter pylori Infection in Symptomatic Children: An International Multi-Centered Study', PLOS ONE, 8 (2013) [C1]
DOI 10.1371/journal.pone.0068833
Citations Scopus - 29Web of Science - 21
2012 Ronkainen J, Walker MM, Aro P, Storskrubb T, Talley NJ, Ahmed ZB, et al., 'Lymphocytic oesophagitis, a condition in search of a disease?', GUT, 61 (2012) [C3]
DOI 10.1136/gutjnl-2012-302329
Citations Web of Science - 6
Co-authors Nicholas Talley
2012 Koloski NA, Jones M, Talley NJ, 'Authors' response', Gut, 61 1776-1777 (2012) [C3]
Citations Scopus - 7Web of Science - 5
Co-authors Nicholas Talley
2012 Darrington RS, Campa VM, Walker M, Bengoa-Vergniory N, Gorrono-Etxebarria I, Uysal-Onganer P, et al., 'Distinct expression and activity of GSK-3a and GSK-3ß in prostate cancer', International Journal of Cancer, 131 E872-E883 (2012) [C1]
DOI 10.1002/ijc.27620
Citations Scopus - 23Web of Science - 21
2012 Chopra S, Rowe E, Laniado M, Walker M, 'Relationship between chronic inflammation at prostate biopsy and transition zone prostate volume enlargement in a prospectively UK screened population', Journal of Clinical Urology, 5 115-119 (2012)

The aim of this study was to evaluate the relationship between histological prostatic inflammation and prostate volume at the time of prostate biopsy. From a prospective prostate ... [more]

The aim of this study was to evaluate the relationship between histological prostatic inflammation and prostate volume at the time of prostate biopsy. From a prospective prostate cancer screening study, 137 men aged 50¿65 years, underwent prostate biopsies negative for cancer, forming the study population. Biopsy criteria were prostate specific antigen (PSA) =4 ng/ml (n = 40), or between 1.1 and 4ng/ml with a percent free PSA (%fPSA) < 25% (n = 97). Total gland (TG) and transition zone (TZ) volumes were measured prior to TRUS guided biopsy. Histological classification included chronic inflammation (CIlymphocyte predominant), active inflammation (AI-neutrophil predominant), and benign prostatic tissue (BPT-no inflammatory cells). A logistic regression analysis was performed using age, TPSA, %fPSA, histology, TZ and TG volume, TZ/TG ratio, PSA density, and transition zone PSA density as continuous variables. We also mailed validated self-administered symptom scores to men in the three histological subgroups (men without cancer) at a median of follow up of 6.5 years (range 5.9¿7.1 years) after screening and biopsy. Histological chronic inflammation (n = 78, 57%) at biopsy was associated with a larger mean TG volume (30.8cc) than active inflammation (n =7, 22.7cc) and benign prostatic tissue (n = 52, 25.9cc). On bivariate analysis, chronic inflammation was associated with greater TZ volume (p = 0.0015) and TZ/TG ratio (p = 0.0008). On multivariate analysis, chronic inflammation was the only independent variable associated with a greater ratio of the TZ to TG volume (odds ratio 478, p = 0.005). IPPS symptoms scores were completed and returned by 88 men (66% compliance). In men with chronic inflammation (49), active inflammation (5), and benign tissue (30), the mean IPSS scores were 10.9, 7.2, and 8.7, respectively. These differences did not reach statistical significance p = 0.05. In this younger screened population, chronic inflammation was associated with greater prostate gland volume secondary to transition zone volume enlargement. Further research is needed to establish a causally related link for this observation. © 2011, British Association of Urological Surgeons. All rights reserved.

DOI 10.1016/j.bjmsu.2011.08.002
Citations Scopus - 1
2012 Sanders DSA, Grabsch H, Harrison R, Bateman A, Going J, Goldin R, et al., 'Comparing virtual with conventional microscopy for the consensus diagnosis of Barrett's neoplasia in the AspECT Barrett's chemoprevention trial pathology audit', Histopathology, 61 795-800 (2012) [C1]
Citations Scopus - 14Web of Science - 13
2012 Low LCM, Carton J, Walker M, Tudor-Williams G, Hardman C, 'Intrauterine Herpes Simplex Virus Infection Presenting with Hypopigmented Lesions', PEDIATRIC DERMATOLOGY, 29 515-517 (2012) [C1]
DOI 10.1111/j.1525-1470.2011.01542.x
Citations Scopus - 3Web of Science - 4
2012 Reebye V, Cano LQ, Lavery DN, Brooke GN, Powell SM, Chotai D, et al., 'Role of the HSP90-associated cochaperone p23 in enhancing activity of the androgen receptor and significance for prostate cancer', Molecular Endocrinology, 26 1694-1706 (2012) [C1]
DOI 10.1210/me.2012-1056
Citations Scopus - 18Web of Science - 17
2012 Khan MAA, Kar A, Walker MM, Lloyd J, Vale JA, Mayer EK, 'A Case of Squamous Cell Carcinoma of the Renal Pelvis in association with Schistosoma hematobium', CASE REPORTS IN ONCOLOGICAL MEDICINE, (2012) [C1]
DOI 10.1155/2012/352401
2012 Mayer EK, Undre S, Cohen DC, Walker MM, Vale JA, Patel A, '"An Unusual Urological Tumour": Above the Collar and below the Belt', CASE REPORTS IN ONCOLOGICAL MEDICINE, (2012) [C1]
DOI 10.1155/2012/480826
2012 Walker MM, Woodward J, 'A clinicopathological approach to the diagnosis of coeliac disease', Diagnostic Histopathology, 18 402-410 (2012) [C1]

Coeliac disease is defined as a small bowel enteropathy due to immune mediated damage on exposure to gluten in the diet, occurring in those with a genetic predisposition to this c... [more]

Coeliac disease is defined as a small bowel enteropathy due to immune mediated damage on exposure to gluten in the diet, occurring in those with a genetic predisposition to this condition. Previously considered rare, the prevalence of coeliac disease is increasing due to a genuine rise in incidence and also better detection. The diagnosis of coeliac disease involves many disciplines, presentation is varied and if the diagnosis is delayed there is a risk of poor quality of life and a small increase in malignancy. Serology is a first line test, followed by confirmatory small intestinal biopsy. This review discusses the clinicopathological approach to diagnosis, through serology and biopsy and discusses complications which occur in some individuals, namely refractory coeliac disease and dermatitis herpetiformis. The entity of non-coeliac gluten sensitivity is also entering the spectrum of coeliac diagnosis and may lead to an extension of the diagnostic parameters of coeliac disease. © 2012 Elsevier Ltd.

DOI 10.1016/j.mpdhp.2012.08.011
Citations Scopus - 2
2012 Fanous RN, Mayer EK, Vale J, Lloyd J, Walker MM, 'Primary renal embryonal rhabdomyosarcoma in adults: a case report and review of the literature.', Case reports in oncological medicine, 2012 460749 (2012) [C1]
DOI 10.1155/2012/460749
2011 Walker MM, Warwick A, Ung C, Talley NJ, 'The role of eosinophils and mast cells in intestinal functional disease', Current Gastroenterology Reports, 13 323-330 (2011) [C1]
DOI 10.1007/s11894-011-0197-5
Citations Scopus - 38
Co-authors Nicholas Talley
2011 Robinson MJ, Tuke PW, Erlwein O, Tettmar KI, Kaye S, Naresh KN, et al., 'No Evidence of XMRV or MuLV Sequences in Prostate Cancer, Diffuse Large B-Cell Lymphoma, or the UK Blood Donor Population.', Advances in Virology, 2011 1-6 (2011) [C1]
DOI 10.1155/2011/782353
Citations Scopus - 10
2011 Ashby J, Ahmed A, Walker M, Wilkinson D, 'The utility of a diagnostic skin biopsy clinic within the genitourinary medicine clinic', International Journal of STD and AIDS, 22 417-418 (2011)
DOI 10.1258/ijsa.2011.010493
Citations Scopus - 1
2011 Brooke GN, Culley RL, Dart DA, Mann DJ, Gaughan L, McCracken SR, et al., 'FUS/TLS is a novel mediator of androgen-dependent cell-cycle progression and prostate cancer growth', Cancer Research, 71 914-924 (2011) [C1]
DOI 10.1158/0008-5472.CAN-10-0874
Citations Scopus - 23Web of Science - 21
2011 Lavery DN, Villaronga MA, Walker M, Patel A, Belandia B, Bevan CL, 'Repression of androgen receptor activity by HEYL, a third member of the hairy/enhancer-of-split-related family of Notch effectors', Journal of Biological Chemistry, 286 7796-7808 (2011) [C1]
DOI 10.1074/jbc.M110.198655
Citations Scopus - 23Web of Science - 22
2011 Walker MM, Talley NJ, 'Clinical value of duodenal biopsies - Beyond the diagnosis of coeliac disease', Pathology Research and Practice, 207 538-544 (2011) [C2]
DOI 10.1016/j.prp.2011.08.001
Citations Scopus - 14Web of Science - 14
Co-authors Nicholas Talley
2010 Uysal-Onganer P, Kawano Y, Caro M, Walker M, Diez S, Darrington RS, et al., 'Wnt-11 promotes neuroendocrine-likedifferentiation, survival and migration of prostatecancer cells.', Molecular Cancer, 9 55-65 (2010) [C1]
DOI 10.1186/1476-4598-9-55
Citations Scopus - 66Web of Science - 60
2010 Robinson MJ, Erlwein OW, Kaye S, Weber J, Cingoz O, Patel A, et al., 'Mouse DNA contamination in human tissue tested for XMRV', Retrovirology, 7 108-108 (2010) [C1]
DOI 10.1186/1742-4690-7-108
Citations Scopus - 96Web of Science - 96
2010 Walker M, Murray JA, Ronkainen J, Aro P, Storskrubb T, D'Amato M, et al., 'Detection of Celiac Disease and Lymphocytic Enteropathy by Parallel Serology and Histopathology in a Population-Based Study', Gastroenterology, 139 112-119 (2010) [C1]
DOI 10.1053/j.gastro.2010.04.007
Citations Scopus - 140Web of Science - 132
Co-authors Nicholas Talley
2010 Khamri W, Walker M, Clark P, Atherton JC, Thursz MR, Bamford KB, et al., 'Helicobacter pylori stimulates dendritic cells to induce interleukin-17 expression from CD4+ T lymphocytes', Infection and Immunity, 78 845-853 (2010) [C1]
DOI 10.1128/IAI.00524-09
Citations Scopus - 55Web of Science - 40
2010 Walker M, Salehian SS, Murray CE, Rajendran A, Hoare JM, Negus R, et al., 'Implications of eosinophilia in the normal duodenal biopsy - An association with allergy and functional dyspepsia', Alimentary Pharmacology and Therapeutics, 31 1229-1236 (2010) [C1]
DOI 10.1111/j.1365-2036.2010.04282.x
Citations Scopus - 59Web of Science - 47
Co-authors Nicholas Talley
2009 Kogianni G, Walker M, Waxman J, Sturge J, 'Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate cancer progression', European Journal of Cancer, 45 685-693 (2009) [C1]
DOI 10.1016/j.ejca.2008.11.023
Citations Scopus - 27Web of Science - 26
2009 Walker M, Talley NJ, Prabhakar M, Pennaneac'H CJ, Aro P, Ronkainen J, et al., 'Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia', Alimentary Pharmacology and Therapeutics, 29 765-773 (2009) [C1]
DOI 10.1111/j.1365-2036.2009.03937.x
Citations Scopus - 115Web of Science - 100
Co-authors Nicholas Talley
2008 Diss JKJ, Fraser SP, Walker M, Patel A, Latchman DS, Djamgoz MBA, 'ß-Subunits of voltage-gated sodium channels in human prostate cancer: Quantitative in vitro and in vivo analyses of mRNA expression', Prostate Cancer and Prostatic Diseases, 11 325-333 (2008) [C1]
DOI 10.1038/sj.pcan.4501012
Citations Scopus - 32Web of Science - 27
2008 Walker M, Teare L, McNulty C, 'Gastric cancer and Helicobacter pylori: The bug, the host or the environment?', Postgraduate Medical Journal, 84 169-170 (2008) [C3]
DOI 10.1136/pgmj.2008.068346
Citations Scopus - 5Web of Science - 3
2008 Storskrubb T, Aro P, Ronkainen J, Sipponen P, Nyhlin H, Talley NJ, et al., 'Serum biomarkers provide an accurate method for diagnosis of atrophic gastritis in a general population: The Kalixanda study', Scandinavian Journal of Gastroenterology, 43 1448-1455 (2008) [C1]
DOI 10.1080/00365520802273025
Citations Scopus - 72Web of Science - 67
Co-authors Nicholas Talley
2008 Walker M, Ellis SM, Auza MJ, Patel A, Clark P, 'The intercellular adhesion molecule, cadherin-10, is a marker for human prostate luminal epithelial cells that is not expressed in prostate cancer', Modern Pathology, 21 85-95 (2008) [C1]
DOI 10.1038/modpathol.3800988
Citations Scopus - 12Web of Science - 11
2007 Khamri W, Worku ML, Anderson AE, Walker M, Hawgood S, Reid KBM, et al., 'Helicobacter infection in the surfactant protein D-deficient mouse', Helicobacter (Oxford), 12 112-123 (2007) [C1]
DOI 10.1111/j.1523-5378.2007.00480.x
Citations Scopus - 7Web of Science - 7
2007 Ronkainen J, Storskrubb T, Hindley LA, Harmsen WS, Zinsmeister AR, Agreus L, et al., 'Non-ulcer Dyspepsia and Duodenal Eosinophilia: An Adult Endoscopic Population-Based Case-Control Study', Clinical Gastroenterology and Hepatology, 5 1175-1183 (2007) [C1]
DOI 10.1016/j.cgh.2007.05.015
Citations Scopus - 122Web of Science - 111
Co-authors Nicholas Talley
2007 Anderson AE, Worku ML, Khamri W, Bamford KB, Walker M, Thursz MR, 'TLR9 polymorphisms determine murine lymphocyte responses to Helicobacter: Results from a genome-wide scan', European Journal of Immunology, 37 1548-1561 (2007) [C1]
DOI 10.1002/eji.200636562
Citations Scopus - 12Web of Science - 11
2007 Ronkainen J, Talley NJ, Aro P, Storskrubb T, Johansson S-E, Lind T, et al., 'Prevalence of oesophageal eosinophils and eosinophilic oesophagitis in adults: The population-based Kalixanda study', Gut, 56 615-620 (2007) [C1]
DOI 10.1136/gut.2006.107714
Citations Scopus - 194Web of Science - 170
Co-authors Nicholas Talley
2006 Kawano Y, Kitaoka M, Hamada Y, Walker M, Waxman J, Kypta RM, 'Regulation of prostate cell growth and morphogenesis by Dickkopf-3', Oncogene, 25 6528-6539 (2006) [C1]
DOI 10.1038/sj.onc.1209661
Citations Scopus - 85Web of Science - 79
2006 Diss JKJ, Faulkes DJ, Walker MM, Patel A, Foster CS, Budhram-Mahadeo V, et al., 'Brn-3a neuronal transcription factor functional expression in human prostate cancer', PROSTATE CANCER AND PROSTATIC DISEASES, 9 83-91 (2006)
DOI 10.1038/sj.pcan.4500837
Citations Scopus - 15Web of Science - 15
2006 Rowe EWJ, Laniado ME, Walker M, Anup P, 'Incidental acute prostatic inflammation is associated with a lower percentage of free prostate-specific antigen than other benign conditions of the prostate: A prospective screening study', BJU International, 97 1039-1042 (2006) [C1]
DOI 10.1111/j.1464-410X.2006.06132.x
Citations Scopus - 9Web of Science - 4
2005 Khamri W, Moran AP, Worku ML, Karim QN, Walker M, Annuk H, et al., 'Variations in Helicobacter pylori lipopolysaccharide to evade the innate immune component surfactant protein D', Infection and Immunity, 73 7677-7686 (2005) [C1]
DOI 10.1128/IAI.73.11.7677-7686.2005
Citations Scopus - 44Web of Science - 44
2005 Belandia B, Powell SM, Garcia-Pedrero JM, Walker M, Bevan CL, Parker MG, 'Hey1, a mediator of Notch signaling, is an androgen receptor corepressor', Molecular and Cellular Biology, 25 1425-1436 (2005) [C1]
DOI 10.1128/MCB.25.4.1425-1436.2005
Citations Scopus - 91Web of Science - 86
2005 Moran AP, Khamri W, Walker M, Thursz MR, 'Role of surfactant protein D (SP-D) in innate immunity in the gastric mucosa: Evidence of interaction with Helicobacter pylori lipopolysaccharide', Journal of Endotoxin Research, 11 357-362 (2005) [C1]
DOI 10.1179/096805105X76832
Citations Scopus - 12Web of Science - 13
2005 Zhu H, Mazor M, Kawano Y, Walker MM, Leung HY, Armstrong K, et al., 'Erratum: Analysis of Wnt gene expression in prostate cancer: Mutual inhibition by WNT11 and the androgen receptor (Cancer Research (November 1, 2004) 64 (7918-7926))', Cancer Research, 65 8057 (2005)
2005 Diss JKJ, Stewart D, Pani F, Foster CS, Walker M, Patel A, Djamgoz MBA, 'A potential novel marker for human prostate cancer: Voltage-gated sodium channel expression in vivo', Prostate Cancer and Prostatic Diseases, 8 266-273 (2005) [C1]
DOI 10.1038/sj.pcan.4500796
Citations Scopus - 94Web of Science - 85
2005 Smith RD, Tran-Dang MA, Khoubehi B, Witherow R, Patel A, Walker MM, 'Stromal nodules and vessel wall proliferation in TURP specimens are associated with failure of medical therapy with alpha blockers', BJU INTERNATIONAL, 95 76-76 (2005)
2005 Rowe EWJ, Laniado ME, Walker M, Patel A, 'Prostate cancer detection in men with a 'normal' total prostate-specific antigen (PSA) level using percentage free PSA: A prospective screening study', BJU International, 95 1249-1252 (2005) [C1]
DOI 10.1111/j.1464-410X.2005.05514.x
Citations Scopus - 5Web of Science - 2
2004 Zhu H, Mazor M, Kawano Y, Walker M, Leung HY, Armstrong K, et al., 'Analysis of Wnt gene expression in prostate cancer: Mutual inhibition by WNT11 and the androgen receptor', Cancer Research, 64 7918-7926 (2004) [C1]
DOI 10.1158/0008-5472.CAN-04-2704
Citations Scopus - 83Web of Science - 71
2004 Dave U, Thursz MR, Ebrahim HY, Burke MM, Townsend ER, Walker M, 'Distribution of laminins in the basement membranes of the upper gastrointestinal tract and Barrett's oesophagus', Journal of Pathology, 202 299-304 (2004) [C1]
DOI 10.1002/path.1526
Citations Scopus - 4Web of Science - 4
2004 Swinn MJ, Walker M, Harbin LJ, Adshead JM, Witherow RO, Vale JA, Patel A, 'Biopsy of the red patch at cystoscopy: Is it worthwhile?', European Urology, 45 471-474 (2004) [C1]
DOI 10.1016/j.eururo.2003.11.019
Citations Scopus - 17Web of Science - 14
2004 Dave U, Taylor-Robinson SD, Walker M, Mahon M, Puri BK, Thursz MR, et al., 'In vitro 1H-magnetic resonance spectroscopy of Barrett's esophageal mucosa using magic angle spinning techniques', European Journal of Gastroenterology and Hepatology, 16 1199-1205 (2004) [C1]
DOI 10.1097/00042737-200411000-00019
Citations Scopus - 12Web of Science - 9
2004 Hemmaway C, Walker M, Deal J, Matutes E, Bain BJ, 'Teaching cases from the Royal Marsden and St Mary's Hospitals case 25. A young boy with massive bilateral renal enlargement', Leukemia and Lymphoma, 45 1301-1303 (2004) [C1]
DOI 10.1080/10428190310001657822
Citations Scopus - 2Web of Science - 2
2003 Laniado ME, McMullen I, Walker M, Patel A, 'Use and rationale of a multicompartment microcassette for site-specific biopsies of the prostate in a consecutive cohort of men', Prostate Cancer and Prostatic Diseases, 6 50-52 (2003) [C1]
DOI 10.1038/sj.pcan.4500624
Citations Scopus - 6Web of Science - 4
2003 Jenks PJ, Jeremy AHT, Robinson PA, Walker M, Crabtree JE, 'Long-term infection with Helicobacter felis and inactivation of the tumour suppressor gene p53 cumulatively enhance the gastric mutation frequency in Big Blue® transgenic mice', Journal of Pathology, 201 596-602 (2003) [C1]
DOI 10.1002/path.1488
Citations Scopus - 30Web of Science - 24
2003 Walker M, 'What is tropical sprue?', Journal of Gastroenterology and Hepatology, 18 887-890 (2003) [C3]
DOI 10.1046/j.1440-1746.2003.03127.x
Citations Scopus - 25Web of Science - 14
2002 Crabtree JE, Court M, Walker MM, Wang JT, Coulson PS, Coggle S, et al., 'The effects of chronic schistosomiasis on murine Helicobacter gastric epithelial cell proliferation.', GASTROENTEROLOGY, 122 A226-A226 (2002)
2002 Walker MM, Negus RP, Rice A, Loh V, Teare J, Thursz MR, 'Gastric biopsy: Where from and how many using the updated Sydney system to evaluate gastritis, atrophy and intestinal metaplasia?', GASTROENTEROLOGY, 122 A332-A332 (2002)
2002 Walker MM, Marshall JC, Morgan MY, 'Helicobacter pylori (Hp) infection in alcohol misusers: Dyspepsia, endoscopy and gastroduodenal pathology.', GASTROENTEROLOGY, 122 A475-A476 (2002)
2002 Walker MM, Negus RP, Rice A, Loh V, Teare J, Thursz MR, 'Gastric biopsy: Where from and how many using the updated Sydney system to evaluate gastritis, atrophy, and intestinal metaplasia?', GUT, 50 A104-A104 (2002)
2002 Dave U, Walker MM, Ebrahim H, Townsend E, Burke M, Thursz MR, 'Laminins: Distribution in normal upper GI tract and Barrett's oesophagus', GUT, 50 A125-A125 (2002)
2002 Murray E, Khamri W, Walker M, Eggleton P, Moran AP, Ferris JA, et al., 'Expression of surfactant protein D in the human gastric mucosa and during Helicobacter pylori infection', Infection and Immunity, 70 1481-1487 (2002) [C1]
DOI 10.1128/IAI.70.3.1481-1487.2002
Citations Scopus - 40Web of Science - 40
2002 Osborn M, Pelling N, Walker M, Fisher C, Nicholson AG, 'The value of 'mesothelium-associated' antibodies in distinguishing between metastatic renal cell carcinomas and mesotheliomas', Histopathology, 41 301-307 (2002) [C1]
DOI 10.1046/j.1365-2559.2002.01527.x
Citations Scopus - 22Web of Science - 15
2002 Walker M, 'Cyclooxygenase-2 expression in early gastric cancer, intestinal metaplasia and Helicobacter pylori infection', European Journal of Gastroenterology and Hepatology, 14 347-349 (2002) [C3]
DOI 10.1097/00042737-200204000-00001
Citations Scopus - 17Web of Science - 13
2002 Walker M, 'Gleason score on biopsy: Is it reliable for predicting the final grade on pathology? (Editorial comment )', BMJ: British Medical Journal, 90 698-699 (2002) [C3]
DOI 10.1046/j.1464-410X.2002.t01-1-02990.x
2002 Walker M, Worku M, Coggle S, Thursz MR, 'A novel method for assessing gastritis in the murine model demonstrates genetically determined variation in response to Helicobacter felis infection', Helicobacter (Oxford), 7 265-268 (2002) [C1]
DOI 10.1046/j.1523-5378.2002.00091.x
Citations Scopus - 10Web of Science - 8
2002 Markou A, Vale J, Vadgama B, Walker M, Franks S, 'Testicular leydig cell tumor presenting as primary infertility.', Hormones (Athens, Greece), 1 251-254 (2002)
2001 Bull JH, Ellison G, Patel A, Muir G, Walker M, Underwood M, et al., 'Identification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray', British Journal of Cancer, 84 1512-1519 (2001) [C1]
DOI 10.1054/bjoc.2001.1816
Citations Scopus - 94
2001 Morris-Jones R, Walker M, Staughton RCD, Sheridan DJ, Rajappan K, Leonard J, Hardman C, 'Lichen myxoedematosus with associated cardiac abnormalities.', British Journal of Dermatology, 144 594-596 (2001) [C1]
DOI 10.1046/j.1365-2133.2001.04091.x
2001 Dave U, Loh V, Teare J, Thursz MR, Walker MM, 'Active inflammation and intestinal metaplasia at the cardia are not related to GORD', GASTROENTEROLOGY, 120 A424-A424 (2001)
2001 Dave U, Mahadeva U, Loh V, Hills K, Thursz MR, Walker MM, 'Peri Z-line biopsy during routine upper GI enddoscopy: From where and how many?', GASTROENTEROLOGY, 120 A428-A428 (2001)
2001 Crabtree JE, Court M, Walker MM, Coulson PS, Coggle S, Robinson PA, et al., 'The effects of chronic schistosomiasis on murine Helicobacter induced gastritis', GASTROENTEROLOGY, 120 A707-A707 (2001)
2001 Sutton P, Danon SJ, Walker M, Thompson LJ, Wilson J, Kosaka T, Lee A, 'Post-immunisation gastritis and helicobacter infection in the mouse: A long term study', Gut, 49 467-473 (2001) [C1]
DOI 10.1136/gut.49.4.467
Citations Scopus - 66
2001 Thilagarajah R, Witherow RO, Walker M, 'Oral cimetidine gives effective symptom relief in painful bladder disease: A prospective, randomized, double-blind placebo-controlled trial', BJU International, 87 207-212 (2001) [C1]
DOI 10.1046/j.1464-410X.2001.02031.x
Citations Web of Science - 63
2001 Walker M, 'Gastric mucosal immune response in Helicobacter pylori infection in children - Men are not mice and more paediatric studies are needed', Digestive and Liver Disease, 33 7-9 (2001) [C1]
Citations Scopus - 1
2000 Morris-Jones R, Walker M, Hardman C, 'Multicentric reticulohistiocytosis associated with Sjogren's syndrome', British Journal of Dermatology, 143 649-650 (2000) [C1]
DOI 10.1046/j.1365-2133.2000.03730.x
Citations Scopus - 15
2000 Walker MM, Teare JP, Negus R, Rice AJ, Loh V, 'Are all five biopsy sites of the updated Sydney system essential to assess gastritis?', GASTROENTEROLOGY, 118 A1320-A1320 (2000)
2000 Marshall JK, Irvine EJ, 'Increased intestinal permeability precedes Crohn's disease (CD) in a subject with familial risk.', GASTROENTEROLOGY, 118 A1356-A1356 (2000)
2000 Marshall JC, Karim NQ, Worku M, Morgan MY, Walker MM, 'Motility and survival of Helicobacter pylori in alcoholic beverages.', GASTROENTEROLOGY, 118 A1356-A1356 (2000)
2000 Griffiths AE, Walker MM, Loh V, Thursz MR, 'Polymorphisms in IL-1 beta and IL-1 receptor antagonist genes increase the risk of gastric atrophy and intestinal metaplasia in patients infected with Helicobacter pylori.', GUT, 47 A53-A54 (2000)
2000 Walker MM, Negus R, Rice AJ, Loh V, Teare J, Thursz MR, 'Are all five sites of the Sydney system essential to assess H-pylori and gastritis?', GUT, 47 A57-A57 (2000)
2000 Walker MM, Worku ML, Karim QN, Thursz MR, 'Mice are not men: The Sydney system does not discriminate the genetically determined degree of gastritis in H-felis infection.', GUT, 47 A62-A62 (2000)
2000 Cassell PG, Saker PJ, Huxtable SJ, Kousta E, Jackson AE, Hattersley AT, et al., 'Evidence that single nucleotide polymorphism in the uncoupling protein 3 [UCP3] gene influences fat distribution in women of European and Asian origin', Diabetologia, 43 1558-1564 (2000)

Aims/hypothesis. Uncoupling proteins are mitochondrial transmembrane carriers implicated in the regulation of energy balance. Dysfunction of UCP3 (the predominant uncoupling prote... [more]

Aims/hypothesis. Uncoupling proteins are mitochondrial transmembrane carriers implicated in the regulation of energy balance. Dysfunction of UCP3 (the predominant uncoupling protein in skeletal muscle) might therefore be expected to reduce thermogenic capacity, alter energy homeostasis and influence predisposition to obesity and Type II (non-insulin-dependent) diabetes mellitus. A variant in the putative promoter region of UCP3 (-55 c¿t) has recently been identified, and an association with obesity reported in French subjects. Our aim was to study the pathophysiological role of this variant in diabetes-related and obesity-related traits using two distinct ethnic populations. Methods. The -55 c¿t variant was genotyped in 85 South Indian and 150 European parent-offspring trios ascertained through Type II diabetic probands and in 455 South Indian subjects initially recruited to an urban survey into the prevalence of diabetes. Results. In South Indian and European parent-offspring trios there was no preferential transmission of either allele at the -55 c¿t polymorphism to diabetic offspring (South Indians, p = 0.60; Europeans, p = 0.15). When family members were analysed for intermediate traits, the t-allele was associated with increased waist-to-hip ratio but only in females (South Indian mothers p = 0.036, daughters p = 0.032: European mothers p = 0.037, daughters p = 0.14). These findings were replicated in South Indian females from the population-based survey (p = 0.039). Conclusion/interpretation. The consistent association between the t-allele at this locus and increased waist-to-hip ratio in women from three separate data sets indicates that variation at this polymorphism (or another locus with which it is in linkage disequilibrium) influences fat distribution but that this effect is restricted to females.

DOI 10.1007/s001250051569
Citations Scopus - 77
1999 Karim QN, Thursz MR, Murray E, Eggleton P, Reid KB, Worku M, Walker MM, 'Kinetic impairment of Helicobacter pylori by the collectin surfactant protein D.', GASTROENTEROLOGY, 116 A745-A745 (1999)
1999 Marshall JC, Morgan MY, Walker MM, 'Upper GI pathology in relation to Helicobacter pylori (Hp) status in alcohol abusers', GUT, 44 A118-A118 (1999)
1999 Marshall JC, Karim QN, Worku ML, Morgan MY, Walker MM, 'Motility and survival of Helicobacter pylori in alcoholic beverages', GUT, 45 A15-A15 (1999)
1999 Walker MM, Karim QN, Worku M, Murray E, Eggleton P, Reid KBM, Thursz MR, 'Direct observation of kinetics and agglutination of Helicobacter pylori with the collectin, surfactant protein D', GUT, 45 A41-A42 (1999)
1999 Walker M, 'HTLV-I infection and the low prevalence of Helicobacter pylori infection in Japan', European Journal of Gastroenterology and Hepatology, 11 481-483 (1999) [C1]
Citations Scopus - 4
1999 Worku ML, Sidebotham RL, Walker M, Keshavarz T, Karim QN, 'The relationship between Helicobacter pylori motility, morphology and phase of growth: Implications for gastric colonization and pathology', Microbiology, 145 2803-2811 (1999) [C1]
Citations Scopus - 28Web of Science - 29
1998 Gummett P, Walker MM, Loh V, Thomas HJW, Teare JP, Thursz MR, 'Advantages of near patient testing for H-pylori using infrared isotope analysis.', GASTROENTEROLOGY, 114 A141-A141 (1998)
DOI 10.1016/S0016-5085(98)80575-1
1998 MacDonald S, Thursz MR, Eggleton P, Reid KBM, Walker MM, 'Surfactant protein D expression in normal and H-pylori-infected human gastric antral mucosa.', GASTROENTEROLOGY, 114 A1028-A1029 (1998)
DOI 10.1016/S0016-5085(98)84186-3
1998 Walker MM, Macdonald S, Thursz MR, Eggleton P, Reid KBM, 'Surfactant protein D expression in normal and H-pylori infected human gastric antral mucosa', GUT, 42 A77-A77 (1998)
1998 Gummett P, Walker MM, Loh V, Thomas HJW, Teare JP, Thursz MR, 'Advantages of near patient testing for H-pylori using infra-red isotope analysis', GUT, 42 A81-A81 (1998)
1998 Walker MM, Thursz MR, Karim QN, MacDonald S, Murray E, Eggleton P, Reid KBM, 'The role of the collectin surfactant protein D in Helicobacter pylori infection', GUT, 43 A16-A16 (1998)
1998 Griffiths AE, Walker MM, Thursz MR, 'Allele 2 of the IL-1 receptor antagonist gene predisposes to chronic H-pylori infection', GUT, 43 A26-A26 (1998)
1998 Griffiths AE, Walker MM, Thursz MR, 'Influence of polymorphisms in the IL-10 and TNFa promoter regions on the outcome of H-pylori infection', GUT, 43 A31-A31 (1998)
1998 Thilagarajah R, Witherow RO, Walker M, 'Quantitative histopathology can aid diagnosis in painful bladder syndrome', Journal of Clinical Pathology, 51 211-214 (1998) [C1]
Citations Web of Science - 6
1998 Walker M, Crabtree JE, 'Helicobacter pylori infection and the pathogenesis of duodenal ulceration', Annals of the New York Academy of Sciences, 859 96-111 (1998) [C1]
DOI 10.1111/j.1749-6632.1998.tb11114.x
Citations Scopus - 52Web of Science - 43
1998 Sidebotham RL, Dhir NK, Elder JB, Spencer J, Walker MM, Schrager J, 'Changes to mucins in uninvolved mucosa and at the tumour site in gastric adenocarcinoma of intestinal type (vol 94, pg 87, 1998)', CLINICAL SCIENCE, 94 333-333 (1998)
1998 Sidebotham RL, Dhir NK, Elder JB, Spencer J, Walker M, Schrager J, 'Changes to mucins in uninvolved mucosa and at the tumour site in gastric adenocarcinoma of intestinal type', Clinical Science, 94 87-99 (1998) [C1]
Citations Scopus - 1Web of Science - 2
1998 Griffiths AE, Thursz MR, Walker MM, Baron JH, 'The immcnogenetics of h. pylori', Zeitschrift fur Gastroenterologie, 36 1092 (1998)

Background The importance of the host in influencing the outcome of H. pylori (Hp) infection is becoming increasingly accepted. The identity of the host genes involved, however, r... [more]

Background The importance of the host in influencing the outcome of H. pylori (Hp) infection is becoming increasingly accepted. The identity of the host genes involved, however, remains unknown. Potential candidate genes include MHC class II genes, cylokine genes and genes involved in mucosal protection and repair. Aim The purpose of this study was to determine if certain polymorphisms, of known functional significance, in the tumour necrosis factor (TNF), Interleukin (IL)-l, IL-10 and mannose binding lectin (MBL) genes, were associated with outcome of Hp infection. Methods From a large DNA bank, matched case and control cohorts of 100150 subjects each of duodenal ulcer (DU), Hp+ non-ulcer dyspepsia (NUD) and Hp-NUD were assembled. Gene polymorphisms were screened by PCR followed by restriction fragment length polymorphism analysis (for TNF308 and IL-1 ß-511 ) or by sequence specific oligonucleotide hybridisation techniques. Allele frequencies were compared between the groups using standard odds ratios and chi squared tests. Results Four TNF and two IL-10 polymorphisms were studied and showed no association with outcome. However individuals homozygous for allele 2 of the IL-1 receptor antagonist gene intron 2 VNTR did show a trend towards increased risk of ulcer (p=0,09). This is the same allele that has been associated with increased severity of inflammation in ulcerative colitis and SLE. The MBL codon 52 mutation was found in 15% of Hp+ patients but only 4% of uninfected controls; odds ratio -3.97 (95%CI 1.33-15.94), p=0.007. Conclusions A known deficiency in innate immunity has been shown to predispose to Hp infection. No genes associated with particular outcome of infection have yet been identified.

1998 Sidebotham RL, Dhir NK, Elder JB, Spencer J, Walker MM, Schrager J, 'Correction: Changes to mucins in uninvolved mucosa and at the tumour site in gastric adenocarcinoma of intestinal type (Clinical Science (1998) 94 (87-99))', Clinical Science, 94 333 (1998)
1997 Thilagarajah R, Vale JA, Witherow RO, Walker M, 'A clinicopathological approach to cystitis -recommendations for simplified pathology reporting', British Journal of Urology (BJU) International, 79 567-571 (1997) [C1]
Citations Scopus - 5Web of Science - 5
1997 Griffiths AE, Thursz MR, Walker MM, 'Do intestinal metaplasia and gastric atrophy reverse after H-pylori eradication?', GASTROENTEROLOGY, 112 A134-A134 (1997)
1997 Walker MM, Sarraf CE, Griffiths AE, Thursz M, Calam J, 'Ultrastructure of neuroendocrine cells in the duodenum of Helicobacter pylori positive patients with duodenal ulcer.', GASTROENTEROLOGY, 112 A324-A324 (1997)
1997 Gibbons AH, Legon S, Walker M, Ghatei M, Calem J, 'The effect of gastrin-releasing peptide on gastrin and somatostatin messenger RNAs in humans infected with Helicobacter pylori', Gastroenterology, 112 1940-1947 (1997) [C1]
DOI 10.1053/gast.1997.v112.pm9178686
Citations Scopus - 27Web of Science - 27
1997 Griffiths AE, Thursz MR, Pryce D, Walker MM, 'Reflux symptoms in the long term follow up of patients after Helicobacter pylori eradication', GUT, 40 W10-W10 (1997)
1997 Griffiths AE, Thursz MR, Walker MM, 'Do intestinal metaplasia and gastric atrophy reverse after H-pylori eradication?', GUT, 41 A48-A49 (1997)
Citations Web of Science - 10
1997 Sullivan J, Thursz MR, Griffiths AE, Walker MM, 'E-cadherin expression in precursor lesions of gastric carcinoma', GUT, 41 A28-A28 (1997)
1997 Griffiths AE, Walker MM, Mantafounis D, Thursz MR, 'The -308 polymorphism in the TNF alpha gene is not associated with increased risk of duodenal ulcer', GUT, 41 A171-A171 (1997)
1997 Hardman CM, Garioch JJ, Leonard JJ, Thomas HJW, Walker M, Lortan JE, et al., 'Absence of Toxicity of Oats in Patients with Dermatitis Herpetiformis', New England Journal of Medicine, 337 1884-1887 (1997) [C1]
DOI 10.1056/NEJM199712253372604
Citations Scopus - 111
1997 Griffiths AE, Walker M, 'Helicobacter pylori and its role in peptic ulcer disease', Nutrition and Food Science, 97 141-145 (1997) [C1]
DOI 10.1108/00346659710179679
1997 Walker M, Baron JH, 'Hunterian peptic ulcers and Helicobacter pylori.', Annals of the Royal College of Surgeons of England, 79 368-371 (1997) [C1]
Citations Scopus - 2Web of Science - 2
1996 Gibbons AH, Jordinson M, Legon S, Walker MM, Calam J, 'Somatostatin mRNA expression is reduced in inflamed gastric mucosa in rats', GASTROENTEROLOGY, 110 A116-A116 (1996)
1996 Pryce DI, Harris AW, Gabe SM, Karim QN, Beveridge I, Langworthy H, et al., 'One week of lansoprazole, clarithromycin and metronidazole eradicates Helicobacter pylori', GASTROENTEROLOGY, 110 A235-A235 (1996)
Citations Web of Science - 12
1996 Walker MM, Harris AW, LeRoux PH, Baron JH, Misiewicz JJ, 'D cells in the antrum are decreased in Helicobacter pylori positive patients with duodenal ulcer due to active inflammation in the foveolar pits.', GASTROENTEROLOGY, 110 A290-A290 (1996)
Citations Web of Science - 1
1996 Harris AW, Gummett PA, Walker M, Misiewicz JJ, Baron JH, 'Relation between gastric acid output, Helicobacter pylori, and gastric metaplasia in the duodenal bulb', Gut, 39 513-520 (1996) [C1]
Citations Scopus - 55Web of Science - 55
1996 Birch HA, Glass JM, Vale J, Walker M, 'Myxoid renal cell carcinoma: Histological, immunocytochemical and ultrastructural study', Journal of Clinical Pathology, 49 1015-1017 (1996) [C1]
Citations Scopus - 2Web of Science - 2
1996 Harris AW, Walker M, Smolka A, Waller JM, Baron JH, Misiewicz JJ, 'Parietal cells in the duodenal bulb and their relation to Helicobacter pylori infection', Journal of Clinical Pathology, 49 309-312 (1996) [C1]
Citations Scopus - 3Web of Science - 2
1996 Walker M, Pretolani S, Gasbarrini G, 'Gastric carcinoma and gastric lymphoma', Current Opinion in Gastroenterology, 12 33-36 (1996) [C1]
Citations Web of Science - 11
1996 Harris AW, Pryce DI, Gabe SM, Karim QN, Walker M, Langworthy H, et al., 'Lansoprazole, clarithromycin and metronidazole for seven days in Helicobacter pylori infection', Alimentary Pharmacology and Therapeutics, 10 1005-1008 (1996) [C1]
Citations Scopus - 42Web of Science - 46
1996 Sarker SK, Mendiola R, Spigelman A, Walker M, Coleman D, 'DNA ploidy on cytologic and tissue sections of breast lumps: A comparison using image analysis', Analytical and Quantitative Cytology and Histology, 18 19-22 (1996) [C1]
Citations Scopus - 4
1996 Walker MM, Pretolani S, Gasbarrini G, 'Gastric carcinoma and gastric lymphoma', Current Opinion in Gastroenterology, 12 33-36 (1996)

The association of gastric adenocarcinoma of intestinal type with gastric lymphoma is well established and the sequence of events leading to this outcome has been studied extensiv... [more]

The association of gastric adenocarcinoma of intestinal type with gastric lymphoma is well established and the sequence of events leading to this outcome has been studied extensively in the past year. Significant developments include recognition of differing host response to Helicobacter pylori, co-factors and the strain of the bacteria in the malignant process. The successful treatment of low grade B cell lymphomas with antimicrobial therapy is further evidence that this tumour is a result of H. pylori infection, although caution must be exercised in selecting suitable cases for treatment.

Citations Scopus - 9
1995 Baker BS, Garioch JJ, Bokth S, Thomas H, Walker M, Leonard JN, Fry L, 'Lack of proliferative response by gluten-specific T cells in the blood and gut of patients with Dermatitis Herpetiformis', Journal of Autoimmunity, 8 561-574 (1995) [C1]
Citations Scopus - 5Web of Science - 5
1995 Birley HDL, Luzzi GA, Taylor-Robinson D, Walker M, Renton AM, 'Retinoic acid derivatives and HPV infection', International Journal of STD and AIDS, 6 368-368 (1995) [C1]
1995 Brace W, Bain B, Walker M, Catovsky D, 'Teaching cases from the Royal Marsden Hospital. Case 9: An elderly patient with unusual circulating cells', Leukemia and Lymphoma, 18 529-530 (1995) [C1]
Citations Scopus - 4
1995 HARRIS AW, WALKER MM, WALLER JM, BARON JH, MISIEWICZ JJ, 'GASTRIC METAPLASM IN THE DUODENAL BULB BEFORE AND 6 MONTHS AFTER ERADICATION OF HELICOBACTER-PYLORI', GASTROENTEROLOGY, 108 A108-A108 (1995)
DOI 10.1016/0016-5085(95)23097-1
Citations Web of Science - 2
1995 LEROUX PH, HARRIS AW, WALKER MM, MISIEWICZ JJ, BARON JH, 'GASTRIC-ACID OUTPUT, BACTERIAL LOAD AND GASTRITIS IN HELICOBACTER-PYLORI POSITIVE PATIENTS WITH DUODENAL-ULCER', GASTROENTEROLOGY, 108 A147-A147 (1995)
DOI 10.1016/0016-5085(95)23251-6
Citations Web of Science - 1
1995 Logan RPH, Walker M, Misiewicz JJ, Gummett PA, Karim QN, Baron JH, 'Changes in the intragastric distribution of Helicobacter pylori during treatment with omeprazole', Gut, 36 12-16 (1995) [C1]
Citations Scopus - 292Web of Science - 338
1995 Purohit A, Ghilchik MW, Duncan L, Wang DY, Singh A, Walker M, Reed MJ, 'Aromatase activity and interleukin-6 production by normal and malignant breast tissues', Journal of Clinical Endocrinology and Metabolism, 80 3052-3058 (1995) [C1]
Citations Scopus - 158Web of Science - 154
1995 Walker M, Smolka A, Waller JM, Evans DJ, 'Identification of parietal cells in gastric body mucosa with HMFG-2 monoclonal antibody', Journal of Clinical Pathology, 48 832-834 (1995) [C1]
Citations Scopus - 9Web of Science - 10
1994 Logan RPH, Gummett PA, Schaufelberger HD, Greaves RRFH, Mendelson GM, Walker M, et al., 'Eradication of Helicobacter pylori with clarithromycin and omeprazole', Gut, 35 323-326 (1994) [C1]
Citations Scopus - 190Web of Science - 207
1994 Logan RHP, Gummett PA, Misiewicz JJ, Karim QN, Walker M, Baron JH, 'One week's anti-Helicobacter pylori treatment for duodenal ulcer', Gut, 35 15-18 (1994) [C1]
Citations Scopus - 43Web of Science - 48
1994 Birley HDL, Luzzi GA, Walker M, Ryait B, Taylor-Robinson D, Renton AM, 'The association of human papillomavirus infection with balanoposthitis: A description of five cases with proposals for treatment', International Journal of STD and AIDS, 5 139-141 (1994) [C1]
Citations Scopus - 7Web of Science - 4
1993 Walker M, Lessing MPA, 'Fatal pulmonary infection due to Mycobacterium fortuitum', Journal of Clinical Pathology, 46 271-272 (1993) [C1]
Citations Scopus - 15Web of Science - 13
1993 Walker M, Duffy T, 'Relative friendly death certificates.', Journal of Clinical Pathology, 46 782-783 (1993) [C3]
DOI 10.1136/jcp.46.8.782-c
Citations Web of Science - 1
1993 Coldham NG, Lai LC, Ghilchik MW, Walker M, James VHT, Reed MJ, 'The effect of treatment with 4-hydroxyandrostenedione or medroxyprogesterone acetate on human breast tumour regression', Anticancer Research: international journal of cancer research and treatment, 13 753-758 (1993) [C1]
Citations Scopus - 3Web of Science - 3
1993 LOGAN RPH, GUMMETT PA, MISIEWICZ JJ, KARIM QN, WALKER MM, BARON JH, '2-WEEK ERADICATION REGIMEN FOR METRONIDAZOLE-RESISTANT HELICOBACTER-PYLORI', ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 7 149-153 (1993)
Citations Web of Science - 21
1993 Logan RPH, Gummett PA, Misiewicz JJ, Karim QN, Walker M, Baron JH, 'Two-week eradication regimen for metronidazole-resistant helicobacter pylori', Alimentary Pharmacology and Therapeutics, 7 149-153 (1993) [C1]
Citations Scopus - 17
1993 Walker M, Logan RPH, Gummett PA, Baron JH, Misiewicz JJ, 'The influence of Helicobacter pylori eradication on the structure of duodenal ulcer scars', European Journal of Gastroenterology and Hepatology, 56 S97-S98 (1993) [C1]
Citations Web of Science - 5
1993 Hillman RJ, Ryait BK, Botcherby M, Walker M, Taylor-Robinson D, 'Human papillomavirus DNA in the urogenital tracts of men with genital dermatoses: Evidence for multifocal infection', International Journal of STD and AIDS, 4 147-154 (1993) [C1]
Citations Scopus - 11Web of Science - 11
1993 Birley HDL, Walker M, Luzzi GA, Bell R, Taylor-Robinson D, Byrne M, Renton AM, 'Clinical features and management of current balanitis; association with atopy and genital washing', Sexually Transmitted Infections, 69 400-403 (1993) [C1]
Citations Scopus - 48Web of Science - 40
1992 Baker BS, Brent L, Valdimarsson H, Powles AV, Al-Imara L, Walker M, Fry L, 'Is epidermal cell proliferation in psoriatic skin grafts on nude mice driven by T-cell derived cytokines?', British Journal of Dermatology, 126 105-110 (1992) [C1]
DOI 10.1111/j.1365-2133.1992.tb07805.x
Citations Scopus - 30
1992 Logan RPH, Hurlimann S, Gummett PA, Walker M, Karim ON, Baron JH, Misiewicz JJ, 'How quickly does Helicobacter pylori (H. pylori) recur after treatment?', Gut, 33 S3-S3 (1992) [C1]
DOI 10.1136/gut.33.1_Suppl.S3
1992 Logan RPH, Gummett PA, Hegarty BT, Walker M, Baron JH, Misiewicz JJ, 'Clarithromycin and omeprazole for Helicobacter pylori', Lancet, 340 239-239 (1992) [C3]
DOI 10.1016/0140-6736(92)90502-T
Citations Scopus - 86Web of Science - 99
1992 HILLMAN RJ, WALKER MM, HARRIS JRW, TAYLORROBINSON D, 'PENILE DERMATOSES - A CLINICAL AND HISTOPATHOLOGICAL STUDY', GENITOURINARY MEDICINE, 68 166-169 (1992)
Citations Scopus - 36Web of Science - 28
1992 Hillman RJ, Waldron S, Walker M, Harris JRW, 'Granuloma annulare of the penis', Sexually Transmitted Infections, 68 47-49 (1992) [C1]
Citations Scopus - 15Web of Science - 16
1991 Logan RPH, Polson RJ, Misiewicz JJ, Rao G, Karim NQ, Newell D, et al., 'Simplified single sample 13Carbon urea breath test for Helicobacter pylori: Comparison with histology, culture, and ELISA serology', Gut, 32 1461-1464 (1991) [C1]
Citations Scopus - 196Web of Science - 195
1991 Logan RPH, Gummett PA, Misiewicz JJ, Karim QN, Walker M, Baron JH, 'One week eradication regimen for Helicobacter pylori', Lancet, 338 1249-1252 (1991) [C1]
DOI 10.1016/0140-6736(91)92111-E
Citations Scopus - 151Web of Science - 173
1991 Watson JAS, Walker M, Smith NP, Hunt DM, 'Malignant chondroid syringoma - A rare cause of secondary bone tumour', Clinical and Experimental Dermatology, 16 306-307 (1991) [C1]
Citations Web of Science - 17
1991 Logan RPH, Dill S, Bauer FE, Walker M, Hirschl AM, Gummett PA, et al., 'The European 13C-urea breath test for the detection of Helicobacter pylori', European Journal of Gastroenterology and Hepatology, 3 915-921 (1991) [C1]
Citations Scopus - 254Web of Science - 246
1991 Hillman RJ, Harris JRW, Walker M, 'Value of performing biopsies in genitourinary clinics', Sexually Transmitted Infections, 67 73-73 (1991) [C3]
Citations Scopus - 1Web of Science - 1
1990 Baron JH, Karim QN, Walker M, 'H pylori and duodenal ulcer', Gut, 31 242-243 (1990) [C3]
1990 Walker M, Karim QN, Payne A, Baron JH, 'Distribution of Campylobacter pylori in the upper and lower gastrointestinal tract: a microbiological and histological study', Journal of Clinical Pathology, 43 82-82 (1990) [C3]
1990 Francis ND, Logan RPH, Walker M, Polson RJ, Boylston AW, Pinching AJ, et al., 'Campylobacter pylori in the upper gastrointestinal tract of patients with HIV-1 infection', Journal of Clinical Pathology, 43 60-62 (1990) [C1]
Citations Scopus - 28Web of Science - 31
1990 Logan RPH, Polson RJ, Baron JH, Walker M, 'New spiral bacterium in the gastric mucosa: Gastrospirillum hominis', Journal of Clinical Pathology, 43 262-262 (1990) [C3]
Citations Scopus - 13Web of Science - 7
1990 Logan RPH, Polson RJ, Rao G, Walker M, Pedley S, Harris JRW, et al., 'Helicobacter pylori and HIV infection', Lancet, 335 1456-1456 (1990) [C3]
Citations Scopus - 11Web of Science - 10
1990 Doble A, Walker M, Harris JRW, Taylor-Robinson D, Witherow OR, 'Intraprostatic antibody deposition in chronic abacterial prostatitis', British Journal of Urology (BJU) International, 65 598-605 (1990) [C1]
Citations Web of Science - 46
1990 Holder P, Plail R, Walker M, Witherow OR, 'Cystitis glandularis - Reversal with intravesical steroid therapy', British Journal of Urology (BJU) International, 65 547-548 (1990) [C1]
Citations Web of Science - 4
1989 Walker M, 'Comprehensive health organizations: the better way?', Health care, 31 45 (1989)
1989 Walker MM, Francis ND, Logan RPH, Poulson RJ, Boylston AW, Pinching AJ, et al., 'Campylobacter pylori in the upper gastrointestinal tract of patients with HIV infection', Gastroduodenal pathology and Campylobacter pylori: proceedings of the first meeting of the European Campylobacter Pylori Study Group. ICS847, 553-556 (1989)
Citations Scopus - 4
1989 McFadden JP, Powles AV, Walker M, 'Rosacea induced by PUVA therapy', British Journal of Dermatology, 121 413-413 (1989) [C3]
DOI 10.1111/j.1365-2133.1989.tb01440.x
Citations Scopus - 6
1989 Logan RPH, Walker M, Francis ND, Kitchen V, Polson RJ, Pinching AJ, Baron JH, 'Campylobacter pylori in acquired immunodeficiency syndrome', Gastroenterology, 96 1229-1229 (1989) [C3]
Citations Scopus - 3
1989 Doble A, Thomas BJ, Walker M, Harris JRW, Witherow OR, Taylor-Robinson D, 'The role of Chlamydia trachomatis in chronic abacterial prostatitis: A study using ultrasound guided biopsy', Journal of Urology, 141 332-333 (1989) [C1]
Citations Web of Science - 66
1989 Logan RPH, Karim QN, Polson RJ, Walker M, Baron JH, Lord MG, et al., 'Gastrospirillum hominis infections of the stomach', Lancet, 2 672-672 (1989) [C1]
DOI 10.1016/S0140-6736(89)90909-4
Citations Scopus - 4Web of Science - 5
1989 Coelho LGV, Payne A, Karim QN, Baron JH, Walker M, 'Campylobacter pylori in esophagus antrum, and duodenum. A histological and microbiological study', Digestive Diseases and Sciences, 34 445-448 (1989) [C1]
Citations Scopus - 23Web of Science - 25
1989 Byrne MA, Walker M, Leonard J, Pryce D, Taylor-Robinson D, 'Recognising covert disease in women with chronic vulval symptoms attending an STD clinic: Value of detailed examination including colposcopy', Sexually Transmitted Infections, 65 46-49 (1989) [C1]
Citations Scopus - 11Web of Science - 13
1989 Witherow OR, Gillespie L, McMullen L, Goldin RD, Walker M, 'Painful bladder syndrome - A clinical and immunopathological study', British Journal of Urology (BJU) International, 64 158-161 (1989) [C1]
Citations Web of Science - 13
1989 Doble A, Thomas BJ, Furr PM, Walker M, Harris JRW, Witherow OR, Taylor-Robinson D, 'A search for infectious agents in chronic abacterial prostatitis using ultrasound guided biopsy', British Journal of Urology (BJU) International, 64 297-301 (1989) [C1]
Citations Web of Science - 33
1988 Shaikh NA, Beaconsfield T, Walker M, Ghilchik MW, 'Postirradiation angiosarcoma of the breast - A case report', European Journal of Surgical Oncology, 14 449-451 (1988) [C1]
Citations Scopus - 44
1987 Coelho LG, Das SS, Karim QN, Walker M, Queiroz DM, Mendes EN, et al., 'Campylobacter pyloridis in the upper gastrointestinal tract: a Brazilian study.', Arquivos de Gastroenterologia, 24 5-9 (1987) [C1]
Citations Scopus - 10
1987 Forbat LN, Walker M, Gribble RJ, Baron JH, 'Lack of clinical value of biopsy of duodenal ulcer at endoscopy.', Gastrointestinal Endoscopy, 33 269-270 (1987) [C3]
Citations Scopus - 1
1987 McMullen L, Walker M, Bain LA, Karim QN, Baron JH, 'Histological identification of Campylobacter using Gimenez technique in gastric antral mucosa', Journal of Clinical Pathology, 40 464-465 (1987) [C1]
Citations Scopus - 35Web of Science - 43
1987 Lambrianides AL, Walker M, Rosin RD, 'Primary retroperitoneal teratoma in adults', Urology, 29 310-312 (1987) [C1]
Citations Scopus - 27Web of Science - 20
1986 GRIFFITHS CEM, LEONARD JN, WALKER MM, 'ACQUIRED ICHTHYOSIS AND SARCOIDOSIS', CLINICAL AND EXPERIMENTAL DERMATOLOGY, 11 296-298 (1986)
DOI 10.1111/j.1365-2230.1986.tb00463.x
Citations Scopus - 11Web of Science - 10
Show 228 more journal articles

Review (11 outputs)

Year Citation Altmetrics Link
2011 Webster P, Wujanto L, Fisher C, Walker M, Ramakrishnan R, Naresh K, et al., 'Malignancies confined to disused arteriovenous fistulae in renal transplant patients: An important differential diagnosis', American Journal of Nephrology (2011) [D1]
DOI 10.1159/000328908
Citations Scopus - 10Web of Science - 13
2011 Walker M, Marray JA, 'An update in the diagnosis of coeliac disease', Histopathology (2011) [D1]
DOI 10.1111/j.1365-2559.2010.03680.x
Citations Scopus - 50Web of Science - 47
2011 Walker M, Talley NJ, 'Clinical value of duodenal biopsies - Beyond the diagnosis of coeliac disease', Pathology Research and Practice (2011) [D1]
DOI 10.1016/j.prp.2011.08.00
2010 Powell N, Walker M, Talley NJ, 'Gastrointestinal eosinophils in health, disease and functional disorders', Nature Reviews Gastroenterology and Hepatology (2010) [D1]
DOI 10.1038/nrgastro.2010.5
Citations Scopus - 49Web of Science - 39
Co-authors Nicholas Talley
2010 Goddard AF, Badreldin R, Pritchard DM, Walker M, Warren B, 'The management of gastric polyps', Gut (2010) [D1]
DOI 10.1136/gut.2009.182089
Citations Scopus - 72Web of Science - 63
2008 Walker M, Talley NJ, 'Functional Gastrointestinal Disorders and the Potential Role of Eosinophils', Gastroenterology Clinics of North America (2008) [D1]
DOI 10.1016/j.gtc.2008.02.007
Citations Scopus - 17Web of Science - 14
Co-authors Nicholas Talley
2003 Walker M, 'Is intestinal metaplasia of the stomach reversible?', Gut (2003) [D1]
DOI 10.1136/gut.52.1.1
Citations Scopus - 40Web of Science - 34
2003 Walker M, Whittle BJR, 'British Journal of Clinical Pharmacology review series Clinical research methods in gastroenterology', British Journal of Clinical Pharmacology (2003) [D1]
DOI 10.1046/j.1365-2125.2003.01940.x
Citations Scopus - 1
2003 Walker M, 'Biopsy assessment of drug efficacy in the gastrointestinal tract.', British Journal of Clinical Pharmacology (2003) [D1]
DOI 10.1046/j.1365-2125.2003.01981.x
2001 Logan RPH, Walker M, 'ABC of the upper gastrointestinal tract: epidemiology and diagnosis of Helicobacter pylori infection.', British Medical Journal (2001) [D1]
Citations Scopus - 127Web of Science - 99
1987 Walker M, Griffiths CEM, Weber J, Leonard JN, Forster JM, Powles AV, et al., 'Dermatological conditions in HIV infection', British Medical Journal (1987) [D1]
Citations Scopus - 9Web of Science - 9
Show 8 more reviews

Conference (56 outputs)

Year Citation Altmetrics Link
2017 Potter MDE, Brogan G, Walker MM, Mcevoy M, Hancock S, Holliday E, et al., 'Susceptibility for celiac disease based on tissue transglutaminase seroprevalence and HLA genotype in a community study', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2017)
Co-authors Mark Mcevoy, John Attia, Nicholas Talley
2017 Koloski NA, Jones MP, Walker MM, Zala AV, Veysey M, Holtmann GJ, Talley NJ, 'PROTON PUMP INHIBITORS, IRRITABLE BOWEL SYNDROME AND FUNCTIONAL DYSPEPSIA - A RANDOM POPULATION BASED STUDY', GASTROENTEROLOGY, Chicago, IL (2017)
Co-authors Martin Veysey, Nicholas Talley
2017 Koloski NA, Jones MP, Walker MM, Zala AV, Veysey M, Holtmann GJ, Talley NJ, 'SELF-REPORTED ASTHMA AND FOOD ALLERGY ARE INDEPENDENT RISK FACTORS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS. A RANDOM POPULATION BASED STUDY', GASTROENTEROLOGY, Chicago, IL (2017)
Co-authors Nicholas Talley, Martin Veysey
2017 Koloski NA, Jones MP, Walker MM, Zala AV, Veysey M, Holtmann GJ, Talley NJ, 'EVIDENCE FOR AN ASSOCIATION BETWEEN CONDITIONS OF IMMUNE DYSREGULATION AND FUNCTIONAL GASTROINTESTINAL DISORDERS. FINDINGS FROM A RANDOM POPULATION BASED STUDY', GASTROENTEROLOGY, Chicago, IL (2017)
Co-authors Nicholas Talley, Martin Veysey
2017 Liu G, Cooley MA, Jarnicki AG, Hsu AC-Y, Nair PM, Haw TJ, et al., 'FIUBLIN-1C PLAYS CRITICAL ROLES IN LUNG REMODELLING IN IDIOPATHIC PULMONARY FIBROSIS', RESPIROLOGY (2017)
Co-authors Darryl Knight, Jay Horvat, Philip Hansbro, Alan Hsu, Michael Fricker
2016 Faulkner S, Jobling P, Rowe C, Oldmeadow C, Roselli S, Thorne R, et al., 'CLINICOPATHOLOGICAL SIGNIFICANCE OF PRONGF RECEPTORS IN THYROID CANCER', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2016)
Co-authors John Attia, Rick Thorne, Christopher Oldmeadow, Hubert Hondermarck, Phillip Jobling
2016 Pundavela J, Dona A, Walker M, Hondermarck H, Ramadan S, 'A NOVEL SCREENING TEST FOR PROSTATE DISEASE USING NUCLEAR MAGNETIC RESONANCE (NMR)', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2016)
Co-authors Saadallah Ramadan, Hubert Hondermarck
2016 McPherson ZE, Horvath-Puho E, Sorensen HT, Norgaard M, McElduff P, McElduff S, et al., 'IRRITABLE BOWEL SYNDROME IS A RISK FACTOR FOR GLAUCOMA; ANALYSIS OF TWO EUROPEAN POPULATION-BASED COHORT STUDIES', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2016)
Co-authors Mark Mcevoy, Nicholas Talley, Patrick Mcelduff
2015 Kheir A, Koloski N, Holtmann G, Walker M, Veysey M, Talley N, 'What keeps gastroenterologists in the public sector busy? A prospective one month snapshot audit', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2015) [E3]
Co-authors Martin Veysey, Nicholas Talley
2015 Walker M, Goodsall T, Zala A, Talley N, Rassam L, Wood N, 'Colonic spirochaetosis, commensal or pathogen?', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2015) [E3]
Co-authors Nicholas Talley
2015 Zala A, Bollipo S, Talley N, Walker M, 'Herpes simplex oesophagitis: inhaled steroids treatment for eosinophilic oesophagitis not always safe', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2015) [E3]
Co-authors Nicholas Talley
2015 Shah A, Talley N, Koloski N, Burger D, Martin N, Walker M, Holtmann G, 'Hen or egg: is there a link between inflammatory bowel and coeliac disease', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2015) [E3]
Co-authors Nicholas Talley
2015 Wauters L, Nightingale S, Sulaiman B, Talley N, Walker M, 'OP-23 FUNCTIONAL DYSPEPSIA IS ASSOCIATED WITH DUODENAL EOSINOPHILIA IN A PEDIATRIC COHORT.', Journal of pediatric gastroenterology and nutrition (2015) [E3]
DOI 10.1097/01.mpg.0000472227.39787.b8
Co-authors Nicholas Talley
2015 Collison AM, Sokulsky LA, Sherrill JD, Nightingale S, Hatchwell L, Talley NJ, et al., 'TRAIL Signalling Is Pro-Inflammatory in Eosinophilic Esophagitis', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Houston, TX (2015) [E3]
Co-authors Joerg Mattes, Adam Collison, Nicholas Talley
2015 Pundavela J, Roselli S, Demont Y, Faulkner S, Attia J, Keene S, et al., 'The neuronal protein sortilin is expressed in aggressive breast cancers and participates in tumor cell growth and invasion', CANCER RESEARCH, San Antonio, TX (2015) [E3]
DOI 10.1158/1538-7445.SABCS14-P6-01-11
Co-authors Hubert Hondermarck, John Attia
2015 Faulkner S, Roselli S, Demont Y, Choquet G, Leissner P, Oldmeadow C, et al., 'ProNGF AS A NEW BIOMARKER IN THYROID CANCER', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2015) [E3]
Co-authors Hubert Hondermarck, Christopher Oldmeadow, John Attia
2015 Nielsen S, Sulaiman B, Goode S, Young B, Koegelenberg A, Thorne R, et al., 'THE ESSENTIAL ROLE OF ANATOMICAL PATHOLOGISTS IN TISSUE BIOBANKING - A WIN- WIN SITUATION', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2015) [E3]
Co-authors Rick Thorne, John Forbes, Rodney Scott
2015 Faulkner S, Lincz L, McElduff P, Scott R, Thorne R, Walker M, et al., 'COMPARING DIGITAL VERSUS VISUAL SCORING METHODS FOR IMMUNOHISTOCHEMICAL STAINING: A CASE STUDY IN THE HUNTER CANCER BIOBANK', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2015) [E3]
Co-authors Lisa Lincz, Rick Thorne, Hubert Hondermarck, Rodney Scott, Patrick Mcelduff
2014 Shah A, Talley NJ, Walker M, Koloski N, Shanahan ER, Morrison M, et al., 'Is geographic variability of incidence and prevalence of Crohn's Disease linked to Helicobacter pylori? An ecologic study', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Co-authors Nicholas Talley
2014 Zala A, Bollipo S, Walker MM, Talley NJ, 'Endoscopic and histologic findings in food bolus obstruction: Not all eosinophilic esophagitis', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Co-authors Nicholas Talley
2014 Faulkner S, Roselli S, Thorne RF, Scarlett CJ, Walker MM, Hondermarck H, 'PRONGF AND SORTILIN EXPRESSION AND FUNCTION IN PANCREATIC CANCER', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
Co-authors C Scarlett, Hubert Hondermarck, Rick Thorne
2013 Patel N, Blackwell VJ, Patel P, Walker MM, Williams HR, 'THE DIAGNOSTIC UTILITY OF ENDOSCOPIC DUODENAL BIOPSIES FOR GASTROINTESTINAL INVESTIGATION', GUT, Glasgow, SCOTLAND (2013) [E3]
DOI 10.1136/gutjnl-2013-304907.670
2012 Aggarwal KR, Walker MM, Shim L, Powell N, Bassan MS, Kalantar JS, et al., 'Duodenal Eosinophilia and Early Satiety in Functional Dyspepsia (FD): Confirmation of a Positive Biomarker Association for FD in an Australian Cohort', GASTROENTEROLOGY, San Diego, CA (2012) [E3]
Citations Web of Science - 1
Co-authors Nicholas Talley
2012 Rakhra GS, Villagran A, Harris PR, Walker MM, Crabtree JE, 'Increased Duodenal Intra Epithelial Lymphocytes (IELs) are Associated With Recurrent Abdominal Pain and Parasite Infection but Not Helicobacter pylori in a Paediatric Chilean Cohort', GASTROENTEROLOGY, San Diego, CA (2012) [E3]
Citations Web of Science - 1
2012 Powell N, Walker MM, Talley NJ, Ronkainen J, Aro P, Storskrubb T, et al., 'Smoking is associated with disordered homeostasis of small intestinal and proximal colonic mucosal mast cells', Gastroenterology: 2012 DDW Abstract Supplement, San Diego, CA (2012) [E3]
Co-authors Nicholas Talley
2012 Walker MM, Rakhra GS, Villagran A, Harri PR, Crabtree JE, 'INCREASED DUODENAL INTRA EPITHELIAL LYMPHOCYTES (IELS) ARE ASSOCIATED WITH RECURRENT ABDOMINAL PAIN AND PARASITE INFECTION BUT NOT HELICOBACTER PYLORI IN A PAEDIATRIC CHILEAN COHORT', GUT (2012) [E3]
DOI 10.1136/gutjnl-2012-302514c.132
2012 Nayagam S, Lloyd K, Byrne E, Walker MM, Williams HRT, 'INVESTIGATIONS FOR COELIAC DISEASE IN IRON DEFICIENCY ANAEMIA-ARE WE FOLLOWING BSG GUIDELINES?', GUT (2012) [E3]
DOI 10.1136/gutjnl-2012-302514d.183
2012 Walker MM, Aggarwal KR, Shim L, Powell N, Bassan M, Kalantar JS, et al., 'Duodenal eosinophilia and early satiety in functional dyspepsia (FD): Confirmation of a positive biomarker association for FD in an Australian cohort', Gut, Liverpool, UK (2012) [E3]
Co-authors Nicholas Talley
2011 Maisnam D, Walker MM, Seneviratne S, 'Audit of Duodenal Biopsy Subsequent to Positive Coeliac Serology, and Reaudit of Coeliac Serology Testing after Histopathological Diagnosis of Lymphocytic Duodenosis', JOURNAL OF PATHOLOGY, Univ Cambridge, Dept Pathol, Cambridge, ENGLAND (2011) [E3]
2011 Queiroz DMM, Harris P, Sanderson I, Rocha AMC, Rocha GA, Villagran A, et al., 'IRON DEFICIENCY ANAEMIA (IDA) AND H. PYLORI INFECTION IN CHILDREN: A MULTICENTERED STUDY', HELICOBACTER, Dublin, IRELAND (2011) [E3]
2010 Duval C, Bransfield K, Walker MM, Varro A, Robinson PA, Crabtree JE, 'LONG-TERM INFECTION OF HELICOBACTER PYLORI 48GX, AND OUTPUT STRAINS 12.2 AND 12.3, RESULTS IN HYPERGASTRINAEMIA, GASTRIC CARCINOIDS AND DYSPLASIA IN MONGOLIAN GERBILS', GUT, Liverpool, ENGLAND (2010) [E3]
DOI 10.1136/gut.2009.208983f
2010 Walker MM, Warwick A, Ung C, Talley NJ, Kjelstrom L, Nyhlin H, et al., 'THE POPCOL STUDY: EPIDEMIOLOGY BY ENDOSCOPY IN A SWEDISH ADULT RANDOM POPULATION. INTRAEPITHELIAL LYMPHOCYTE AND EOSINOPHIL COUNTS IN THE NORMAL COLON AND IRRITABLE BOWEL SYNDROME', GUT, Liverpool, ENGLAND (2010) [E3]
DOI 10.1136/gut.2009.209049i
Co-authors Nicholas Talley
2009 Chopra S, Mayer K, Havranek E, Walker MM, Patel A, 'Does presence of Perineural invasion at biopsy correlate to upgrading of Gleason score/stage of radical prostatectomy specimens?', BJU INTERNATIONAL, Gold Coast, AUSTRALIA (2009) [E3]
2009 Sandhu DK, Foxx-Orenstein AE, Jensen KL, Smyrk TC, Zinsmeister AR, Walker MM, Talley NJ, 'Serotonin, Eosinophils and Mast Cells in Functional Bowel Disorders: Regional Differences in the Gastrointestinal Tract', GASTROENTEROLOGY, Chicago, IL (2009) [E3]
Co-authors Nicholas Talley
2009 Walker MM, Salehian SS, Murray CE, Hoare JM, Negus R, Powell N, Talley NJ, 'IMPLICATIONS OF EOSINOPHILS IN DUODENAL BIOPSIES: AN ASSOCIATION WITH ATOPY, ALLERGY, MEDICATION AND EARLY SATIETY', GUT, Glasgow, SCOTLAND (2009) [E3]
Co-authors Nicholas Talley
2008 Kogianni G, Walker MM, Waxman J, Sturge J, 'Endo180 expression by tumour cells with an invasive phenotype correlates with prostate cancer progression', EJC SUPPLEMENTS, Lyon, FRANCE (2008) [E3]
DOI 10.1016/S1359-6349(08)71480-0
2008 Rahim MN, Hoare JM, Walker MM, Negus R, Macnaughtan J, 'Lymphocytic duodenosis: Clinical presentation and investigation in a retrospective study of 55 patients', GASTROENTEROLOGY (2008) [E3]
2008 Walker MM, Murray CE, Rahim MN, Hoare JM, Negus R, Talley NJ, 'Eosinophilia is overlooked in routine duodenal biopsy practice and is linked to a history of atopy or medication', GASTROENTEROLOGY (2008) [E3]
Co-authors Nicholas Talley
2008 Walker MM, Talley NJ, Prabhakar M, Pennaneach CJ, Rorkainen J, Aro P, et al., 'Duodenal mast cell hyperplasia and nerve proximity in irritable bowel syndrome', GASTROENTEROLOGY (2008) [E3]
Co-authors Nicholas Talley
2008 Rahim M, Macnaughtan J, Hoare J, Negus R, Walker MM, 'Lymphocytic duodenosis: Clinical presentation and investigation in a retrospective study of 55 patients', GUT, Brimingham, ENGLAND (2008) [E3]
2008 Walker MM, Talley NJ, Prabhakar M, Pennaneac'h C, Aro P, Ronkainen J, et al., 'Duodenal mastocytosis in irritable bowel syndrome: An adult endoscopic population-based case-control study (Kalixanda)', GUT, Brimingham, ENGLAND (2008) [E3]
Co-authors Nicholas Talley
2008 Khamri W, Walker MM, Atherton JC, Thursz MR, Bamford KB, Lechler RI, Lombardi G, 'Helicobacter pylori stimulates dendritic cells to induce IL-17 expression from CD4(+) T lymphocytes', IMMUNOLOGY, Glasgow, SCOTLAND (2008) [E3]
2008 Kogianni G, Walker MM, Waxman J, Sturge J, 'ENDO180 EXPRESSION BY TUMOUR CELLS WITH AN INVASIVE PHENOTYPE CORRELATES WITH PROSTATE CANCER PROGRESSION', ANTICANCER RESEARCH (2008) [E3]
2007 Talley NJ, Walker MM, Aro P, Ronkainen JA, Storskrubb T, Hindley LA, et al., 'Duodenal eosinophilia and mast cell infiltration in functional dyspepsia (FD) and irritable bowel syndrome (IBS): Duodenal eosinophilia a biomarker for FD but not IBS in adults?', GASTROENTEROLOGY, Washington, DC (2007)
Citations Web of Science - 2
Co-authors Nicholas Talley
2007 Walker MM, Murray JA, Ronkainen JA, Aro P, Storskrubb T, Vieth M, et al., 'Lymphocytic duodenosis (LD) in a population based study (Kalixanda) - Sorting the wheat from the chaff', GASTROENTEROLOGY, Washington, DC (2007)
Co-authors Nicholas Talley
2006 Tran-Dang M-A, Smith RD, Khoubehi B, Patel A, Walker MM, 'Stromal nodules and vessel wall thickening in TURP specimens are associated with failure of alpha-blocker treatment', JOURNAL OF PATHOLOGY, Manchester, ENGLAND (2006)
2006 Ronkainen J, Talley NJ, Aro P, Storskrubb T, Bolling-Sternevald E, Lind T, et al., 'Prevalence of eosinophilia and eosinophilic Esophagitis in adults in the community: A random population based study (Kalixanda)', GASTROENTEROLOGY, Los Angeles, CA (2006)
Citations Web of Science - 5
Co-authors Nicholas Talley
2006 Walker MM, Goldin RD, Vieth M, Stolte M, Ronkainen J, Aro P, et al., 'A practical method for counting Intraepithelial lymphocytes in duodenal biopsies: Data from a population-based endoscopic study', GASTROENTEROLOGY, Los Angeles, CA (2006)
Co-authors Nicholas Talley
2005 Murray JA, Walker MM, Agreus L, Storskrubb T, Ronkainen J, Aro P, Talley NJ, 'Celiac disease: Defining the abnormal threshold for the intra-epithelial lymphocyte count in a random population-based endoscopic study', GASTROENTEROLOGY, Chicago, IL (2005)
Co-authors Nicholas Talley
2003 Walker MM, 'Classification of duodenitis and villous atrophy', UPDATE IN PATHOLOGY, PROCEEDINGS, Ljubljana, SLOVENIA (2003)
2003 Walker MM, Ebrahim H, Burke M, Townsend E, Thursz M, 'Columnar lined oesophagus (CLO) a tissue culture model for basement membrane manipulation', GASTROENTEROLOGY, ORLANDO, FLORIDA (2003)
DOI 10.1016/S0016-5085(03)82067-X
2002 Walker MM, Smolka AJ, Coggle S, Dubois A, 'Acute Helicobacter pylori infection and H,K-ATPase expression: Digital immunoquantitation of proton pumps in non-human primates', GUT, ATHENS, GREECE (2002)
2002 Walker MM, Crabtree J, Wang J, Coulson P, Coggle S, Robinson P, Telford J, 'The effects of chronic Schistosomiasis on murine Helicobacter gastric epithelial cell proliferation', GUT, ATHENS, GREECE (2002)
1996 Walker M, Dixon MF, 'Gastric metaplasia: Its role in duodenal ulceration', Alimentary Pharmacology and Therapeutics, Supplement, Edinburgh, UK (1996) [E2]
Citations Scopus - 30Web of Science - 29
1993 Walker MM, Logan RPH, Gummett PA, Baron JH, Misiewicz JJ, 'The influence of Helicobacter pylori eradication on the structure of duodenal ulcer scars', European Journal of Gastroenterology and Hepatology (1993)

Objectives: To determine the quality of duodenal ulcer healing following treatment with standard regimens of Helicobacter pylori eradication, or with omeprazole, ranitidine and de... [more]

Objectives: To determine the quality of duodenal ulcer healing following treatment with standard regimens of Helicobacter pylori eradication, or with omeprazole, ranitidine and de nol. Design: The study was designed to determine whether changes in gastric metaplasia and microvilli occur at an ultrastructural level before and after various treatments. Patients and methods: Twelve patients with duodenal ulcers (nine males, three females), all judged positive for H. pylori by the [ 13 C]-urea breath test, were studied. Bi opsies were obtained immediately before treatment and 1 month later. Four standard treatment regimens were instituted for 1 month, comprising (1) 1 week of eradication therapy (one tablet de nol each day, 500 mg amoxycillin each day and 2 g metronidazole on each of the last 3 days), (2) 40 mg omeprazole each morning, (3) 300 mg ranitidine each morning and (4) one tablet de nol each day. The groups were matched for age and sex. Gastric (fundus, body and antrum) and duodenal biopsies (edge of duodenal ulcer or its scar) were taken and studied by light microscopy; the duodenal biopsies were also examined by electron microscopy. All ulcers were endoscopically healed after 1 month. Results: After treatment, all the biopsies in the eradication group were negative for H. pylori, but present in one or more sites in all the other treatment groups. However, the duodenal inflammatory response decreased in all groups. There was no apparent change in gastric metaplasia or the quality of microvilli in response to any of the four treatments. Conclusions: Healing of ulcer sites after eradication of H. pylori is a prolonged process. At the ultrastructural level, epithelial integrity was not restored within the time-scale of this study.

Citations Scopus - 3
1993 Logan R, Poison R, Walker M, Gummett P, Baron H, Misiewicz G, 'Defining the role of Helicobacter pylori in relationship to relapse of duodenal ulcer.', Third workshop of the European Helicobacter pylori Study Group. Proceedings., Toledo, Spain (1993) [E1]
Show 53 more conferences
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Grants and Funding

Summary

Number of grants 11
Total funding $3,507,415

Click on a grant title below to expand the full details for that specific grant.


20172 grants / $220,000

Targeting Nerves as a New Therapeutic Strategy in Pancreatic Cancer$200,000

Funding body: Maitland Cancer Appeal Committee

Funding body Maitland Cancer Appeal Committee
Project Team Professor Hubert Hondermarck, Doctor Phil Jobling, Professor Marjorie Walker
Scheme Research Project
Role Investigator
Funding Start 2017
Funding Finish 2019
GNo G1700836
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

A therapy against pancreatic cancer and associated pain $20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Hubert Hondermarck, Doctor Phil Jobling, Professor Marjorie Walker, Doctor Rick Thorne
Scheme Project Grant
Role Investigator
Funding Start 2017
Funding Finish 2017
GNo G1701538
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20163 grants / $284,677

Biomarkers for functional gut disorders Australia (BFGD Australia)$216,000

Funding body: Commonwealth Diagnostics International Inc

Funding body Commonwealth Diagnostics International Inc
Project Team Laureate Professor Nick Talley, Professor Marjorie Walker, Professor Gerald Holtmann, Associate Professor Michael Jones, Associate Professor Simon Keely
Scheme Commonwealth Laboratories Study
Role Investigator
Funding Start 2016
Funding Finish 2017
GNo G1601324
Type Of Funding International - Non Competitive
Category 3IFB
UON Y

A novel biomarker and innovative therapeutic strategy for oesophageal cancer$48,677

Funding body: Hunter New England Local Health District

Funding body Hunter New England Local Health District
Project Team Professor Hubert Hondermarck, Professor Marjorie Walker, Doctor Vanessa Wills, Doctor Phil Jobling, Professor John Attia, Professor Robert Rush
Scheme Project Grant
Role Investigator
Funding Start 2016
Funding Finish 2016
GNo G1601109
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Utilising nanotechnology to target eosinophilic GI disease (EGID)$20,000

Funding body: ausEE Inc.

Funding body ausEE Inc.
Project Team Doctor Susan Hua, Laureate Professor Nick Talley, Professor Marjorie Walker
Scheme Research Grant
Role Investigator
Funding Start 2016
Funding Finish 2016
GNo G1600470
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20153 grants / $380,520

The Hunter Cancer Biobank (HCB): Maximising community value through validation, annotation and distribution throughout NSW$300,000

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Professor Marjorie Walker, Conjoint Professor Stephen Ackland, Laureate Professor Rodney Scott, Professor John Forbes, Professor Xu Dong Zhang, Doctor Pradeep Tanwar, Doctor Nikola Bowden, Doctor Craig Gedye, Doctor James Lynam, Doctor Kelly Kiejda, Doctor Jennette Sakoff, Mr Loui Rassam, Dr Tara Roberts, Professor Soon Lee, Dr Betty Kan
Scheme Research Infrastructure Grants
Role Lead
Funding Start 2015
Funding Finish 2018
GNo G1500825
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Pathophysiology of functional dyspepsia: Integration of upper gut function, inflammation and a systems biology approach$65,520

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Gerald Holtmann, Laureate Professor Nick Talley, Associate Professor Michael Jones, Professor Marjorie Walker
Scheme Project Grant
Role Investigator
Funding Start 2015
Funding Finish 2018
GNo G1500455
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Nerves and Neurotrophins as New Therapeutic Targets in Cervical Cancer$15,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Hubert Hondermarck, Doctor Phil Jobling, Professor Marjorie Walker, Ms Janine Lombard, Doctor Jay Pundavela
Scheme Project Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1501579
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20143 grants / $2,622,218

Development and validation of a blood test to identify IBS$1,600,000

Funding body: Prometheus Therapeutics & Diagnostics

Funding body Prometheus Therapeutics & Diagnostics
Project Team

Laureate Professor Nick Talley

Scheme Research Grant
Role Investigator
Funding Start 2014
Funding Finish 2017
GNo
Type Of Funding International - Non Competitive
Category 3IFB
UON N

Functional dyspepsia: Characterisation of the immunopathology and testing a novel therapeutic strategy.$739,604

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Nick Talley, Professor Marjorie Walker, Associate Professor Michael Jones, Dr Nick Powell, Mrs Natasha Koloski, Professor Gerald Holtmann
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2017
GNo G1300107
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

High Throughput Image Capture Platform for Translational Cancer Research$282,614

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Conjoint Professor Stephen Ackland, Laureate Professor Rodney Scott, Professor John Forbes, Professor Xu Dong Zhang, Professor Marjorie Walker, Professor Hubert Hondermarck, Doctor Craig Gedye, Doctor Rick Thorne, Mr Loui Rassam, Doctor Stephen Braye
Scheme Research Equipment Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1400626
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y
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Research Supervision

Number of supervisions

Completed7
Current9

Total current UON EFTSL

PhD1.9

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2017 PhD Improving the Role of Pharmacists in Primary Care of IBD Patients PhD (Pharmacy), Faculty of Health and Medicine, The University of Newcastle Principal Supervisor
2017 PhD The Role of Wheat Proteins in Dyspepsia PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2017 PhD Immune characterisation of patients with functional gastrointestinal and motility disorders PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2017 PhD The Impact of Surgery, Inflammation and Sepsis on Neutrophil Extracellular Trap (NET) Formation and Subsequent Metastatic Disease in Colorectal Cancer PhD (Surgical Science), Faculty of Health and Medicine, The University of Newcastle Principal Supervisor
2017 PhD Modulation of the Microbiota in Irritable Bowel Syndrome PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2017 PhD Mechanisms of Stress-Induced Intestinal Inflammation in GI Disease PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2017 PhD Nerve Dependence in Human Cancers PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2016 PhD Dietary factors influencing functional and motility disorders of the gastrointestinal tract PhD (Human Physiology), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2014 PhD Functional Dyspepsia and Gastroparesis in Health and Diabetes: Characterisation of Gastrointestinal Sensorimotor Patterns and Mucosal Permeability PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2012 Masters Detection of Possible Intracellular Bacteria in Bladder Biopsies of Women with Overactive Bladder Symptoms Biological Sciences, Unknown Sole Supervisor
2011 Masters Functional Dyspepsia and the Transient Receptor Potential Vanilloid 1. Biological Sciences, Imperial College London Sole Supervisor
2010 Masters Allergic Immune Pathways in Functional Bowel Disease in the Lower Gastrointestinal Tract Biological Sciences, Imperial College London Sole Supervisor
2009 Masters Eosinophils, Mast cells, Serotonin and Neural Pathways in the Upper Gastrointestinal Tract in Functional Gastrointestinal Disorders: Functional Dyspepsia and Irritable Bowel Syndrome Biological Sciences, Imperial College London Sole Supervisor
2008 Masters Eosinophils, mast cells and the brain-gut axis in the duodenum of patients with non-ulcer dyspepsia Biological Sciences, Unknown Sole Supervisor
2003 PhD Laminins in Barrett’s oesophagus Biological Sciences, Imperial College London Sole Supervisor
2003 PhD The utility of free/total PSA ratios as a screening tool in the detection of prostate cancer in men aged 50-65 years Biological Sciences, Imperial College London Sole Supervisor
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Research Collaborations

The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.

Country Count of Publications
United Kingdom 216
Australia 87
United States 35
Sweden 18
Germany 7
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News

Think you’re gluten intolerant? Perhaps think again

September 4, 2017

Researchers from the University of Newcastle (UON) have highlighted the potential risks of following a gluten-free diet, urging the community to only drastically change their eating habits if formally diagnosed with coeliac disease.

Professor Marjorie Walker

New approach for diagnosing and treating coeliac disease

August 21, 2017

A review article led by the University of Newcastle (UON) has revealed a recommended approach for the diagnosis and management of coeliac disease in Australia.

Hubert Hondermarck

Study strikes a nerve with the spread of cancer

March 27, 2017

A group led by University of Newcastle biochemistry researcher Hubert Hondermarck has found parallels between tissue regeneration, nerve growth and tumour development, confirming for the first time that the nervous system is strongly implicated in the onset and spread of cancer.

Professor Marjorie Walker

Position

Professor of Anatomical Pathology
School of Medicine and Public Health
Faculty of Health and Medicine

Focus area

Pathology

Contact Details

Email marjorie.walker@newcastle.edu.au
Phone (02) 4921 5316
Mobile 0409 258 746

Office

Room BB107
Building Bowman Building
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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