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Conjoint Professor Margaret Dunkley

Conjoint Professor

School of Biomedical Sciences and Pharmacy (Immunology and Microbiology)

Career Summary

Biography

I have worked within the University of Newcastle environment for 30 years. Initially I was employed on NHMRC research grants and was the Chief investigator on some of these. The focus of my research has been investigation of immune responses to infectious diseases at mucosal surfaces (lung, intestine, and reproductive tract), and development of effective mucosal vaccines. I am also a member of the VIVA group within the Hunter Medical Research Institute.

For the past 15 years I have been employed by small biotech companies that have had their R&D units embedded within the University of Newcastle. In my industry role I have successfully obtained government AUS-Industry R&D grants. Currently, as a Conjoint Associate Professor in School of Biomedical Sciences and Pharmacy, Faculty of Health, I lecture to Biomedical Sciences students, supervise post-graduate students, and collaborate on research projects within the Discipline of Immunology and Microbiology.

I also Chair the University of Newcastle Biosafety Committee and I am a Vice Chancellor nominated employer representative member of the University OH&S committee. I am employed by Newcastle Innovation to work as the Chief Scientific Officer for Hunter Immunology Ltd (an unlisted public company) and I am responsible for the operation of the Hunter Immunology Ltd R&D Unit which is located within the School of Biomedical Science and Pharmacy in the David Maddison Clinical Sciences Building. In this role I also interact with manufacturing and pre-clinical and clinical research contractors. The focus of Hunter Immunology Ltd is vaccine development.

Research Expertise
Research into immune mechanisms for protection against infectious disease and development of vaccines using both animal models and human clinical trials

Teaching Expertise
Teach in areas of immunology, infectious disease, development of products (such as vaccines, diagnostic kits) and regulatory requirements, clinical trials and quanity control and quality assurance

Administrative Expertise
Chair Insititutional Biosafety Committee for University of Newcastle, have completed MBA (Technology management), manage research and development programs for industry

Collaborations
Vaccine Development, Infectious Disease, Immunology

Qualifications

  • PhD (Pathology), University of Newcastle
  • Bachelor of Science (Biochemistry)(Honours), University of Melbourne
  • Master of Science, University of Melbourne
  • Graduate Certificate of Management (Tech Mgt), Deakin University
  • Graduate Diploma of Managment (Tech Management), Deakin University
  • Master of Business Administration, La Trobe University

Keywords

  • Clinical trials
  • Immunology
  • Infectious diseases
  • Product development
  • Quality assurance
  • Vaccine

Fields of Research

Code Description Percentage
110399 Clinical Sciences not elsewhere classified 40
110799 Immunology not elsewhere classified 40
110899 Medical Microbiology not elsewhere classified 20

Professional Experience

Academic appointment

Dates Title Organisation / Department
1/11/2004 -  Chief Scientific Officer University of Newcastle
Hunter Immunology Ltd
Australia
1/01/2001 - 1/01/2005 Chief Scientist-Vaccines University of Newcastle
VRI Biomedical Ltd Newcastle R&D Unit
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (62 outputs)

Year Citation Altmetrics Link
2016 Clancy RL, Dunkley ML, Sockler J, Mcdonald CF, 'Multi-site placebo-controlled randomised clinical trial to assess protection following oral immunisation with inactivated non-typeable Haemophilus influenzae in chronic obstructive pulmonary disease', Internal Medicine Journal, 46 684-693 (2016) [C1]

© 2016 Royal Australasian College of Physicians. Background: Previous studies identified factors that modify response to an oral non-typeable Haemophilus influenzae (NTHi) vaccin... [more]

© 2016 Royal Australasian College of Physicians. Background: Previous studies identified factors that modify response to an oral non-typeable Haemophilus influenzae (NTHi) vaccine in chronic obstructive pulmonary disease (COPD): severe COPD, moderate-severe exacerbations as end-point and a threshold prevalence of NTHi in the study population. More data are needed to confirm parameters that influence clinical outcomes. Aims: The primary aim was to determine the efficacy of an oral NTHi vaccine (HI-164OV) in reducing the rate of exacerbations requiring systemic corticosteroids or hospitalisation in COPD. Secondary aims included effect on the proportion of patients experiencing such exacerbations, severity of infections and quality of life (St George Respiratory Questionnaire for COPD patients (SGRQ-C)). Methods: This multi-centre, double-blind, placebo-controlled study was conducted at 21 Australian sites for 9 months in 2011. Results: Three-hundred and twenty subjects with COPD, FEV 1 < 60% predicted and =1 moderate-severe exacerbations in the previous 12 months were recruited. The primary and secondary end-points for the intention-to-treat population aged 40-88 years were not achieved, and only 5% of subjects had an H. influenzae-positive sputum sample. Subsequent exploratory analysis of patients < 65years (91 subjects) indicated protection with respect to the primary and most of the secondary end-points, with SGRQ-C symptom scores lower at 3 and 6 months. Conclusion: Patients aged 40-88 years with moderate to severe COPD and low rates of H. influenzae-positive sputum were not protected against exacerbations by HI-1640V. Further studies are needed to confirm protection in subjects aged < 65years. Older age and low colonisation rates appear to affect adversely response to this vaccine.

DOI 10.1111/imj.13072
Citations Scopus - 2Web of Science - 2
2012 Essilfie A-T, Simpson JL, Dunkley ML, Morgan LC, Oliver BG, Gibson PG, et al., 'Combined haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma', Thorax, 67 588-599 (2012) [C1]
DOI 10.1136/thoraxjnl-2011-200160
Citations Scopus - 63Web of Science - 56
Co-authors Paul Foster, Jodie Simpson, Peter Gibson, Philip Hansbro
2011 Essilfie A-T, Simpson JL, Horvat JC, Preston JA, Dunkley ML, Foster PS, et al., 'Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease', PLoS Pathogens, 7 e1002244 (2011) [C1]
Co-authors Paul Foster, Philip Hansbro, Jodie Simpson, Jay Horvat, Peter Gibson
2011 Clancy RL, Dunkley ML, 'Acute exacerbations in COPD and their control with oral immunization with non-typeable Haemophilus influenzae', Frontiers in Immunology, 2 1-6 (2011) [C1]
DOI 10.3389/fimmu.2011.00007
Citations Scopus - 14Web of Science - 11
2011 Clancy RL, Dunkley ML, 'A vaccine to prevent exacerbations in COPD', Medical Journal of Australia, 195 99-100 (2011) [C3]
Citations Scopus - 3Web of Science - 3
2010 Clancy RL, Dunkley ML, 'Oral non-typable Haemophilus influenzae enhances physiological mechanism of airways protection', Clinical and Experimental Immunology, 161 127-133 (2010) [C1]
DOI 10.1111/j.1365-2249.2010.04142.x
Citations Scopus - 11Web of Science - 12
2010 Tandon MK, Phillips M, Waterer G, Dunkley ML, Comans P, Clancy RL, 'Oral immunotherapy with inactivated nontypeable haemophilus influenzae reduces severity of acute exacerbations in severe COPD', Chest, 137 805-811 (2010) [C1]
DOI 10.1378/chest.09-1382
Citations Scopus - 25Web of Science - 25
2008 Cripps AW, Sutton P, Beagley K, Robertson S, Dunkley ML, 'Mucosal immunology down under: Special Interest Group in Mucosal Immunology workshop, Australasian Society for Immunology, Sydney, Australia, 2 December 2007', Immunology and Cell Biology, 86 557-561 (2008) [C2]
DOI 10.1038/icb.2008.53
Citations Scopus - 1
2006 Cripps AW, Peek K, Dunkley ML, Vento K, Marjason JK, McIntyre ME, et al., 'Safety and immunogenicity of an oral inactivated whole-cell Pseudomonas aeruginosa vaccine administered to healthy human subjects', Infection and Immunity, 74 968-974 (2006) [C1]
DOI 10.1128/IAI.74.2.968-974.2006
Citations Scopus - 28Web of Science - 23
2006 Vorobjova T, Ren Z, Dunkley ML, Clancy RL, Maaroos HI, Labotkin R, et al., 'Response of IgG1 and IgG2 subclasses to Helicobacter pylori in subjects with chronic inflammation of the gastric mucosa, atrophy and gastric cancer in a country with high Helicobacter pylori infection prevalence', APMIS, 114 372-380 (2006) [C1]
DOI 10.1111/j.1600-0463.2006.apm_392.x
Citations Scopus - 5Web of Science - 5
2005 Ren Z, Borody TJ, Pang GT, Dunkley ML, Clancy RL, Xia HHX, et al., 'Evaluation of anti-Helicobacter pylori IgG2 antibody for the diagnosis of Helicobacter pylori infection in western and Chinese populations', Alimentary Pharmacology & Therapeutics, 21 83-89 (2005) [C1]
DOI 10.1111/j.1365-2036.2004.02293.x
Citations Scopus - 4Web of Science - 5
2005 Ren Z, Borody T, Pang GT, Li L-C, Dunkley ML, Clancy RL, 'Selective reduction of anti-Helicobacter pylori IgG subclass antibody in gastric carcinoma', Journal of Gastroenterology and Hepatology, 20 1338-1343 (2005) [C1]
DOI 10.1111/j.1440-1746.2005.03859.x
Citations Scopus - 7Web of Science - 8
2003 Dunkley ML, Rajyaguru S, McCue AL, Cripps AW, Kyd J, 'Pseudomonas aeruginosa-specific IgG1 and IgG2 subclasses in enchancement of pulmonary clearance following passive immunisation in the rat', FEMS Immunology and Medical Microbiology, 39 37-44 (2003) [C1]
DOI 10.1016/S0928-8244(03)00176-7
Citations Scopus - 10Web of Science - 10
2003 Thomas LD, Kyd JM, Bastin DA, Dunkley ML, Cripps A, 'Immunisation with non-integral OMPs promotes pulmonary clearance of Pseudomonas aeruginosa', FEMS Immunology and Medical Microbiology, 37 155-160 (2003) [C1]
DOI 10.1016/S0928-8244(03)00073-7
Citations Scopus - 14Web of Science - 14
2001 Dunkley ML, Clancy RL, 'Influenza-induced bacterial infection: reduced number of airway macrophages', International Congress Series, 0 581-585 (2001) [C1]
2001 Ren Z, Pang G, Clancy R, Chen Li L, Soon Lee C, Batey RG, et al., 'Gastric Carcinoma: T-Cell Response and Vascularity. Shift of the gastric T-cell response in gastric carcinoma', Journal of Gastroenterology and Hepatology, 16 142-148 (2001) [C1]
DOI 10.1046/j.1440-1746.2001.02385.x
2001 Ren ZG, Pang G, Clancy R, Li LC, Lee CS, Batey R, et al., 'Shift of the gastric T-cell response in gastric carcinoma', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 16 142-148 (2001)
DOI 10.1046/j.1440-1746.2001.02385.x
Citations Scopus - 46Web of Science - 42
2000 Thomas LD, Dunkley ML, Moore R, Reynolds S, Bastin DA, Kyd JM, Cripps AW, 'Catalase immunization from Pseudomonas aeruginosa enhances bacterial clearance in the rat lung', Vaccine, 19 348-357 (2000) [C1]
Citations Scopus - 16Web of Science - 13
2000 Ren Z, Pang GT, Lee R, Batey R, Dunkley ML, Borody T, Clancy RL, 'Circulating T-cell response to Helicobacter pylori infection in chronic gastritis', Helicobacter, 5 (3) 135-141 (2000) [C1]
Citations Scopus - 29Web of Science - 29
2000 Ren Z, Pang GT, Batey R, Routley D, Russell A, Musicka M, et al., 'Non-urease producing Helicobacter pylori in chronic gastritis', Australian & New Zealand Journal of Medicine, 30 (5) 578-584 (2000) [C1]
Citations Scopus - 7Web of Science - 9
1999 Black C, Eyers F, Dunkley ML, Clancy RL, Beagley KW, 'Major histocompatibility haplotype does not impact the course of experimentally induced murine vaginal candidiasis', Laboratory Animal Science, 49, No.6 668-672 (1999) [C1]
Citations Scopus - 13Web of Science - 11
1999 Ren Z, Pang GT, Musicka M, Dunkley ML, Batey R, Beagley KW, Clancy RL, 'Coccoid forms of Helicobacter pylori can be viable', Microbios, 97 153-163 (1999) [C1]
Citations Scopus - 17Web of Science - 13
1999 Black C, Eyers F, Russell A, Dunkley ML, Clancy RL, Beagley KW, 'Increased severity of Candida vaginitis in BALB/c nu/nu mice versus the parent strain is not abrogated by adodptive transfer of T cell enriched lymphocytes', Journal of Reproductive Immunology, 45 1-18 (1999) [C1]
Citations Scopus - 21Web of Science - 16
1999 Dunkley ML, Harris S, McCoy R, Musicka M, Eyers F, Beagley L, et al., 'Protection against Helicobacter pylori infection by intestinal immunisation with a 50/52-kDa subunit protein', FEMS Immunology and Medical Microbiology, 24 221-225 (1999) [C1]
Citations Scopus - 14Web of Science - 13
1999 Clancy RL, Corrigan E, Dunkley ML, Eyers F, Beagley KW, 'Recurrent vulvovaginal candidiasis - allergy or immune deficiency?', Int Arch Allergy Immunol, 118(2-4) 349-350 (1999) [C1]
Citations Scopus - 5Web of Science - 5
1999 Clancy RL, Dunkley ML, Pang GT, 'In favor of a tolerant respiratory tract', Mucosal Immunology Update, 7, No.4 15-17 (1999) [C1]
1998 Corrigan E, Clancy RL, Dunkley ML, Eyres F, Beagley KW, 'Cellular immunity in recurrent vulvovaginal candidasis', Clinical Experimental Immunology, 111 574-578 (1998) [C1]
Citations Scopus - 43Web of Science - 32
1998 Black C, Eyers F, Russell A, Dunkley ML, Clancy RL, Beagley KW, 'Acute Neutropenia Decreases Inflammation associated with murine vaginal candodiasis but has no effect on the course of infection', Infection and Immunity, 66, No. 3 1273-1275 (1998) [C1]
Citations Scopus - 46Web of Science - 42
1997 Cripps AW, Dunkley ML, Clancy RL, Kyd J, 'Vaccine strategies against Pseudomonas aeruginosa infection in the lung.', Behring Institute Mitteilungen, 262-268 (1997)

Pseudomonas aeruginosa is an environmentally ubiquitous, extracellular opportunistic gram-negative bacteria that causes significant morbidity and mortality to a disproportionately... [more]

Pseudomonas aeruginosa is an environmentally ubiquitous, extracellular opportunistic gram-negative bacteria that causes significant morbidity and mortality to a disproportionately high degree for infections with this bacteria compared with other gram-negative bacteria. Patients at particular risk of infection are those with compromised respiratory function, in intensive-care support and taking immunocompromising pharmaceutical agents. Once acquired, infection is difficult to eradicate with chemotherapy and attempts to vaccinate against infection have been of little success. Over the past five years, we have pursued the concept of mucosal immunisation against respiratory infection with P. aeruginosa. Initial studies in an acute animal model clearly demonstrated that mucosal immunisation with a killed whole bacterial cell preparation could induce protective immune responses in the lung. Subsequent studies have shown that the protective immune mechanisms were dependent on antigen specific CD4+ T cells, the activation of alveolar macrophages, the recruitment and activation of polymorphs, predominantly neutrophils, the controlled secretion of TNF-alpha, IL-1 and IFN gamma and the presence of antibody. We have hypothesised that the protective response is under the control of T cells. A pre-clinical human trial of an oral whole killed cell preparation has been completed with no adverse side effects. A limited open trial in patients with bronchiectasis has also been completed. Preliminary analysis of the results has demonstrated that after oral vaccination, specific lymphocyte responses were observed to P. aeruginosa.

Citations Scopus - 18
1995 CRIPPS AW, DUNKLEY ML, CLANCY RL, KYD J, 'PULMONARY IMMUNITY TO PSEUDOMONAS-AERUGINOSA', IMMUNOLOGY AND CELL BIOLOGY, 73 418-424 (1995)
DOI 10.1038/icb.1995.65
Citations Web of Science - 32
1995 WILSON NR, DUNKLEY ML, BURET A, YOUNG B, CRIPPS AW, 'HISTOPATHOLOGY OF THE LUNG FOLLOWING INTRATRACHEAL CHALLENGE WITH LIVE PSEUDOMONAS-AERUGINOSA IN INTESTINALLY IMMUNIZED RATS', IMMUNOLOGY AND CELL BIOLOGY, 73 440-445 (1995)
DOI 10.1038/icb.1995.68
Citations Web of Science - 5
1995 DUNKLEY M, PABST R, CRIPPS A, 'AN IMPORTANT ROLE FOR INTESTINALLY DERIVED T-CELLS IN RESPIRATORY DEFENSE', IMMUNOLOGY TODAY, 16 231-236 (1995)
DOI 10.1016/0167-5699(95)80165-0
Citations Scopus - 58Web of Science - 54
1995 CRIPPS AW, DUNKLEY ML, CLANCY RL, KYD J, 'Pulmonary immunity to Pseudomonas aeruginosa', Immunology and Cell Biology, 73 418-424 (1995)

Pseudomonas aeruginosa, an oportunistic bacterial pathogen, is a major course of morbidity and mortality in subjects with compromised respiratory function despite the significant ... [more]

Pseudomonas aeruginosa, an oportunistic bacterial pathogen, is a major course of morbidity and mortality in subjects with compromised respiratory function despite the significant advances in therapeutic practices. The bacteria produces an armoury of products which modify its infective niche to ensure bacterial survival. The role of antibody in protection against pulmonary infection remains poorly defined. Protection appears to be associated with opsonizing antibody whilst some other antibody responses may be deleterious and promote further lung damage. Cell mediated responses are clearly important in protection against infection. This review proposes a vaccine strategy aimed at enhancing specific T cell responses in the lung which, through T cell-derived cytokines, drive the recruitment of neutrophils to the lung and the subsequent activation of these cells results in the clearance of bacteria from the lung. Copyright © 1995, Wiley Blackwell. All rights reserved

DOI 10.1111/j.1440-1711.1995.tb03891.x
Citations Scopus - 36
1995 WILSON N, DUNKLEY M, BURET A, YOUNG B, CRIPPS A, 'Histopathology of the lung following intratracheal challenge with live Pseudomonas aeruginosa in intestinally immunized rats', Immunology and Cell Biology, 73 440-445 (1995)

This paper examines the histology of rat lungs following intestinal immunization with killed mucoid Pseudomonas aerugtnosa and subsequent pulmonary challenge with live P. aerugino... [more]

This paper examines the histology of rat lungs following intestinal immunization with killed mucoid Pseudomonas aerugtnosa and subsequent pulmonary challenge with live P. aeruginosa. The lungs of non-immune challenged rats developed a confluent haemorrhagic pneumonitis with degeneration and sloughing of the mucosa of the airways; perivascular infiltration with mononuclear cells was apparent 1¿2 h post-challenge; some neutrophils were present by 2 h post-challenge; by 12h post-challenge oedema and intra-alveolar haemorrhage were prominent and Gram-negative organisms were seen in large quantities. In contrast, immunized challenged animals showed a pronounced neutrophilic response 1¿2 h post-challenge; by 12 h post-challenge patchy abscesses were apparent with resolving inflammation and no organisms visible. The findings suggest that intestinal immunization prevents the development of fatal P. aeruginosa infections in the lung by accelerating the recruitment of polymorphonuclear neutrophils Copyright © 1995, Wiley Blackwell. All rights reserved

DOI 10.1111/j.1440-1711.1995.tb03894.x
Citations Scopus - 5
1995 CLANCY R, PANG G, DUNKLEY M, TAYLOR D, CRIPPS A, 'ACUTE ON CHRONIC-BRONCHITIS - A MODEL OF MUCOSAL IMMUNOLOGY', IMMUNOLOGY AND CELL BIOLOGY, 73 414-417 (1995)
DOI 10.1038/icb.1995.64
Citations Scopus - 16Web of Science - 15
1995 KYD JM, DUNKLEY ML, CRIPPS AW, 'ENHANCED RESPIRATORY CLEARANCE OF NONTYPABLE HAEMOPHILUS-INFLUENZAE FOLLOWING MUCOSAL IMMUNIZATION WITH P6 IN A RAT MODEL', INFECTION AND IMMUNITY, 63 2931-2940 (1995)
Citations Scopus - 74Web of Science - 69
1994 CRIPPS AW, DUNKLEY ML, CLANCY RL, 'MUCOSAL AND SYSTEMIC IMMUNIZATIONS WITH KILLED PSEUDOMONAS-AERUGINOSA PROTECT AGAINST ACUTE RESPIRATORY-INFECTION IN RATS', INFECTION AND IMMUNITY, 62 1427-1436 (1994)
Citations Scopus - 61Web of Science - 61
1994 DUNKLEY ML, CLANCY RL, CRIPPS AW, 'A ROLE FOR CD4(+) T-CELLS FROM ORALLY IMMUNIZED RATS IN ENHANCED CLEARANCE OF PSEUDOMONAS-AERUGINOSA FROM THE LUNG', IMMUNOLOGY, 83 362-369 (1994)
Citations Scopus - 53Web of Science - 51
1994 BURET A, DUNKLEY ML, PANG G, CLANCY RL, CRIPPS AW, 'PULMONARY IMMUNITY TO PSEUDOMONAS-AERUGINOSA IN INTESTINALLY IMMUNIZED RATS - ROLES OF ALVEOLAR MACROPHAGES, TUMOR-NECROSIS-FACTOR-ALPHA, AND INTERLEUKIN-1-ALPHA', INFECTION AND IMMUNITY, 62 5335-5343 (1994)
Citations Scopus - 62Web of Science - 64
1993 KYD J, DUNKLEY M, CLANCY R, CRIPPS A, 'VARIATION IN PROTECTION FOLLOWING IMMUNIZATION WITH P6 TO NONTYPABLE HAEMOPHILUS-INFLUENZAE CHALLENGE', JOURNAL OF LEUKOCYTE BIOLOGY, 112-112 (1993)
1993 BURET A, DUNKLEY ML, CRIPPS AW, 'EFFECTOR MECHANISMS OF PULMONARY IMMUNITY TO PSEUDOMONAS-AERUGINOSA FOLLOWING INTESTINAL IMMUNIZATION', AMERICAN REVIEW OF RESPIRATORY DISEASE, 147 A204-A204 (1993)
1993 BURET A, DUNKLEY M, CLANCY RL, CRIPPS AW, 'EFFECTOR MECHANISMS OF INTESTINALLY INDUCED IMMUNITY TO PSEUDOMONAS-AERUGINOSA IN THE RAT LUNG - ROLE OF NEUTROPHILS AND LEUKOTRIENE B4', INFECTION AND IMMUNITY, 61 671-679 (1993)
Citations Scopus - 35Web of Science - 37
1993 DUNKLEY ML, MADSEN G, HUSBAND AJ, 'HETEROGENEITY OF HELPER T-CELL SUBSETS IN PEYER PATCHES', IMMUNOLOGY LETTERS, 37 181-186 (1993)
DOI 10.1016/0165-2478(93)90029-2
Citations Scopus - 3Web of Science - 2
1993 DUNKLEY ML, BURET AG, CRIPPS AW, 'A ROLE FOR IFN-GAMMA IN ENHANCED BACTERIAL CLEARANCE OF PSEUDOMONAS-AERUGINOSA FROM THE LUNG FOLLOWING INTESTINAL IMMUNIZATION WITH KILLED BACTERIA', JOURNAL OF LEUKOCYTE BIOLOGY, 111-111 (1993)
1990 Husband A, Dunkley M, 'Helper T cell control of mucosal immune responses', Today's Life Science, 2 22-31 (1990)
Citations Scopus - 3
1990 DUNKLEY ML, HUSBAND AJ, UNDERDOWN BJ, 'COGNATE T-CELL HELP IN THE INDUCTION OF IGA RESPONSES INVIVO', IMMUNOLOGY, 71 16-19 (1990)
Citations Scopus - 13Web of Science - 16
1990 DUNKLEY ML, HUSBAND AJ, 'ROUTES OF PRIMING AND CHALLENGE FOR IGA ANTIBODY-CONTAINING CELL RESPONSES IN THE INTESTINE', IMMUNOLOGY LETTERS, 26 165-170 (1990)
DOI 10.1016/0165-2478(90)90140-L
Citations Scopus - 19Web of Science - 23
1990 Dunkley ML, Husband AJ, 'The role of non-B cells in localizing an IgA plasma cell response in the intestine', Regional Immunology, 3 336-340 (1990)
Citations Scopus - 25
1989 Dunkley ML, Husband AJ, 'Role of antigen in migration patterns of T cell subsets arising from gut-associated lymphoid tissue.', Regional immunology, 2 213-224 (1989)

Studies of the migration of antigen-specific regulatory T cell subsets responding to gut immunization were undertaken to clarify their migratory potential and the role of antigen ... [more]

Studies of the migration of antigen-specific regulatory T cell subsets responding to gut immunization were undertaken to clarify their migratory potential and the role of antigen in their localization. In initial experiments, lymphocytes collected from the thoracic duct of rats after immunization of Peyer's patches (PP) with keyhole limpet hemocyanin (KLH), were enriched for T helper (Th) cells and labelled with the fluorochrome H33342. In other experiments, a higher frequency of antigen-specific T cells was achieved by short-term culture of the enriched Th cells in the presence of KLH and the blast cells labelled with 3H-thymidine. The distribution of both populations was determined after injection into immunized and unimmunized syngeneic recipients. Whereas the uncultured population (predominantly small Th cells) localized almost exclusively in follicular lymphoid tissues, the cells expanded by secondary culture (predominantly Th blasts) appeared in the gut lamina propria (LP) initially, then in PP and mesenteric lymph nodes. The Th blasts in the LP were almost always seen in close proximity to the gut epithelium. However, the migration of neither population appeared to be influenced significantly by antigen, in contrast to previous findings with regard to IgA-committed B cells. The initial subepithelial location of Th blasts in the gut LP and their subsequent appearance in PP may provide a mechanism by which antigen presented by epithelial cells could influence B cell differentiation in PP through modulation of signals expressed by these T cells.

Citations Scopus - 12
1987 Dunkley ML, Husband AJ, 'Antigen-specific helper T cells in the intestine: origin and migration.', Advances in Experimental Medicine and Biology, 216 A 119-130 (1987)
1987 DUNKLEY ML, HUSBAND AJ, 'DISTRIBUTION AND FUNCTIONAL-CHARACTERISTICS OF ANTIGEN-SPECIFIC HELPER T-CELLS ARISING AFTER PEYER PATCH IMMUNIZATION', IMMUNOLOGY, 61 475-482 (1987)
Citations Scopus - 29Web of Science - 43
1986 DUNKLEY ML, HUSBAND AJ, 'THE INDUCTION AND MIGRATION OF ANTIGEN-SPECIFIC HELPER-CELLS FOR IGA RESPONSES IN THE INTESTINE', IMMUNOLOGY, 57 379-385 (1986)
Citations Scopus - 22Web of Science - 34
1985 DUNKLEY M, CRIPPS A, SCICCHITANO R, CLANCY R, 'RYE GRASS ALLERGEN INDUCED LYMPHOCYTE-PROLIFERATION', ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, 3 77-83 (1985)
Citations Scopus - 1
1985 HUSBAND AJ, DUNKLEY ML, 'LACK OF SITE OF ORIGIN EFFECTS ON DISTRIBUTION OF IGA ANTIBODY-CONTAINING CELLS', IMMUNOLOGY, 54 215-221 (1985)
Citations Scopus - 8Web of Science - 16
1984 HUSBAND AJ, DUNKLEY ML, 'T-CELL REGULATION OF THE MUCOSAL IGA IMMUNE-RESPONSE', JOURNAL OF LEUKOCYTE BIOLOGY, 36 417-417 (1984)
1984 HUSBAND AJ, DUNKLEY ML, CRIPPS AW, CLANCY RL, 'ANTIGEN-SPECIFIC RESPONSE AMONG LYMPHOCYTES-T FOLLOWING INTESTINAL ADMINISTRATION OF ALLOANTIGENS', AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 62 687-699 (1984)
DOI 10.1038/icb.1984.65
Citations Scopus - 11Web of Science - 16
1984 HUSBAND AJ, DUNKLEY ML, SCICCHITANO R, SHELDRAKE RF, 'INDUCTION AND DELIVERY OF MUCOSAL IMMUNE-RESPONSES', JOURNAL OF DENTAL RESEARCH, 63 465-469 (1984)
DOI 10.1177/00220345840630032001
Citations Web of Science - 1
1981 Russell PJ, Cunningham J, Dunkley M, Wilkinson NM, 'The role of suppressor T cells in the expression of autoimmune haemolytic anaemia in NZB mice', Clinical and Experimental Immunology, 45 496-503 (1981)

The course of haemolytic anaemia in NZB mice has been altered by injection of spleen cells from diseased mice into younger ones before the onset of clinical disease. Recipients gr... [more]

The course of haemolytic anaemia in NZB mice has been altered by injection of spleen cells from diseased mice into younger ones before the onset of clinical disease. Recipients greater than 6 weeks of age developed early-onset autoimmune disease; recipients less than 6 weeks of age recovered from early induced disease and showed a delay in the onset of spontaneous disease as compared with untreated NZB mice. This delay was due to the induction in the young mice of splenic suppressor cells. These cells were non-adherent to nylon wool and suppressed autoantibody formation on transfer to old Coombs-positive recipients. Suppressor cells active against autoantibody-producing cells may be present in young untreated NZB mice, but not in sufficient numbers to suppress autoantibody production on adoptive transfer to Coombs-positive recipients; however, when Ig-negative cells from the spleens of very young NZB mice were transferred together with Ig-positive cells from Coombs-positive donor mice to irradiated NZB recipients, the autoantibody production of the transferred B cells was suppressed in some cases. Suppressor cell activity could also be induced by co-culture of spleen cells from old Coombs-positive and young Coombs-negative NZB mice in vitro.

Citations Scopus - 4
1978 Shortman K, Dunkley M, Ryden A, 'Some requirements for a linear cell dose response in vitro assay for the T-cell progenitors of cytotoxic lymphocytes', Journal of Immunological Methods, 19 369-385 (1978)

To develop a precise assay for the T-cell progenitors of cytotoxic lymphocytes (CL-progenitors), lymphoid cells were cultured under optimal conditions in Marbrook vessels with mit... [more]

To develop a precise assay for the T-cell progenitors of cytotoxic lymphocytes (CL-progenitors), lymphoid cells were cultured under optimal conditions in Marbrook vessels with mitomycin-treated allogeneic stimulator cells, and the total level of CL produced 5 days later estimated by a modified 51 Cr release assay. Conditions were adjusted so an arithmetically linear cell dose response relationship was obtained. Three aspects of the cell dose response curve required attention. (1) At low responding cell inputs a macrophage-like cell became limiting (despite the presence of allogeneic macrophages in the stimulating cell population), leading to a lag in the response. This limitation was overcome by adding a low level of irradiated syngeneic macrophages, or by using irradiated syngeneic spleen 'filler' cells. (2) The slope of the resultant linear dose response region could be reduced if desired by changing from cellophane dialysis membranes to 0.1 µ pore size nuclepore membranes, suggesting a stimulatory role for some higher molecular weight soluble factor produced in the cultures. (3) At higher responding cell inputs a marked and extensive plateu was obtained. CL developing early in the response appeared to be destroying the allogeneic stimulator cells causing the response to be self-limiting. This problem was overcome by using a responding cell concentration lower than commonly employed. Assays using mixed leukocyte cultures in the lag or plateau regions could give misleading values for CL-progenitor activity. It is suggested that some examples of apparent synergism in CL generation may have resulted from these effects, rather than T-cell helper T-cell progenitor interactions. © 1978.

DOI 10.1016/0022-1759(78)90021-2
Citations Scopus - 7
1977 Shortman K, Ryden A, Dunkley M, Von Boehmer H, 'Some requirements for the response of separated T-cell sub-populations to the mitogens phytohaemagglutinin and concanavalin A', Australian Journal of Experimental Biology and Medical Science, 55 585-603 (1977)

The proliferative response of various separated populations of mouse spleen and thymus lymphocytes to the mitogen phytohaemagglutinin (PHA) was not a direct function of the level ... [more]

The proliferative response of various separated populations of mouse spleen and thymus lymphocytes to the mitogen phytohaemagglutinin (PHA) was not a direct function of the level of responsive T cells, but was governed by other regulatory effects. These included a stimulation by adherent macrophages, an inhibition by a separate population of adherent cells and an adherent cell independent restriction of proliferation at high cell concentration. In contrast, the proliferative response to Concanavalin A (Con A) was more closely related to the level of responsive T cells. All density and electrophoretically isolated sub-sets of splenic T cells appeared capable of a proliferative response to PHA and Con A, although under some conditions the PHA responsiveness of certain fractions was suppressed. In the thymus, the minor low T subpopulation appeared capable of response to both mitogens, and accounted for all the activity of the unfractioned thymus cells. No response to either mitogen could be obtained from the major, high T thymocyte population.

Citations Scopus - 7
1974 Miller RG, Dunkley M, 'Quantitative analysis of the

Using 51 Cr-labelled P-815 mastocytoma cells as target cells and CS7BL/6 spleen cells sensitized against DBA/2 antigens as effector cells, it is shown that the variation in the o... [more]

Using 51 Cr-labelled P-815 mastocytoma cells as target cells and CS7BL/6 spleen cells sensitized against DBA/2 antigens as effector cells, it is shown that the variation in the observed specific 51 Cr release over a broad range of experimental conditions can be explained on the basis of a simple physical model of the interaction process. The model assumes that a target cell can be destroyed only after contact with an effector cell, contact takes place on a random basis, one contact is sufficient, and that one effector cell can kill several targets with unchanged efficiency. The fraction of target cells destroyed (f) depends only on the incubation time (t), the number of effector cells (n) and a constant interaction probability (d). Thus f = 1 - e -ndt . However, the experimental measurement, the fraction of 51 Cr specifically released into the supernatant during the assay, may not be the same as the fraction of target cells destroyed because it takes considerable time for the releasable 51 Cr to be released from a damaged target cell. This can be overcome experimentally by following the standard 37 °C incubation with a further incubation at 45 °C during which there are no new lytic events but all previously damaged target cells release the remainder of their releasable 51 Cr. The model enables one to obtain accurate measurements of relative effector cell frequency over a broad range of experimental conditions. © 1974.

DOI 10.1016/0008-8749(74)90212-3
Citations Scopus - 98
1974 Dunkley M, Miller RG, Shortman K, 'A modified

An improved 51 Cr release assay for cytotoxic lymphocytes has been developed. The assay system combines the technical advantages of a titration tray method with a modification wh... [more]

An improved 51 Cr release assay for cytotoxic lymphocytes has been developed. The assay system combines the technical advantages of a titration tray method with a modification which enables a more quantitative measure of the cytotoxicity of sensitized cell preparations in a shorter time. A simple mathematical model describing the cytotoxic lymphocyte-target cell interaction has been shown to apply to this system. The advantages and limitations of the assay system are discussed and the recommended procedure is described in detail. © 1974.

DOI 10.1016/0022-1759(74)90088-X
Citations Scopus - 27
Show 59 more journal articles

Conference (21 outputs)

Year Citation Altmetrics Link
2011 Hansbro PM, Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, et al., 'Infection-induced neutrophilic allergic airways disease is resistant to steroid treatment', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authors Peter Gibson, Jay Horvat, Jodie Simpson, Paul Foster, Philip Hansbro
2011 Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, Beagley KW, et al., 'Investigation of infection-induced steroid resistant asthma', Respirology, Perth, WA (2011) [E3]
Co-authors Jay Horvat, Jodie Simpson, Peter Gibson, Paul Foster, Philip Hansbro
2010 Hansbro PM, Essilfie A-T, Simpson JL, Dunkley ML, Horvat JC, Gibson PG, Foster PS, 'Haemophilus influenzae induces IL-17-mediated neutrophilic allergic airways disease', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
Citations Scopus - 65Web of Science - 60
Co-authors Peter Gibson, Paul Foster, Jay Horvat, Jodie Simpson, Philip Hansbro
2009 Essilfie A-T, Simpson JL, Dunkley ML, Foster PS, Gibson PG, Hansbro PM, 'Haemophilus influenzae infection induces features of neutrophilic asthma', Respirology, Darwin, NT (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Philip Hansbro, Paul Foster, Jodie Simpson, Peter Gibson
2008 Virago M-CE, Dunkley ML, 'A journey past the sun and back: Using art psychotherapy to investigate the connection between immunological and psychosocial function following a diagnosis of melanoma', Psycho-Oncology, Irvine, CA (2008) [E3]
Citations Web of Science - 1
2008 Virago M-CE, Dunkley ML, Hazelton MJ, 'What the hand draws, the eye sees and the soul hears: art psychotherapy and the BodyMind in psycho-oncology: the possibility of mixed methods research and art psychotherapy', Psycho-Oncology, Madrid, Spain (2008) [E3]
DOI 10.1002/pon.1389
Co-authors Michael Hazelton
2008 Essilfie A-T, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Haemophilus influenzae (Hi) infection in asthma may drive the development of neutrophilic asthma (NA)', Respirology, Melbourne, VIC (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Paul Foster, Philip Hansbro, Jay Horvat, Peter Gibson, Jodie Simpson
2008 Hansbro PM, Essilfie A-T, Simpson JL, Dunkley ML, Gibson PG, Foster PS, 'Haemophilus influenzae (HI) infection induces features of neutrophilic asthma', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book, Canberra, ACT (2008) [E3]
Co-authors Philip Hansbro, Jodie Simpson, Paul Foster, Peter Gibson
2007 Essiflie A, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Elucidating the association between Haemophilus influenzae infection and neutrophilic allergic airways disease using mouse models', Immuno 2007: 13th International Congress of Immunology. Abstracts and Posters, Rio de Janeiro, Brazil (2007) [E3]
Co-authors Paul Foster, Philip Hansbro, Peter Gibson, Jodie Simpson, Jay Horvat
2006 Virago MCE, Dunkley M, Hzelton M, Collins SM, 'Looking at the connection between the immune system and psychosocial function: A PhD research project', PSYCHO-ONCOLOGY (2006)
2005 Dunkley M, 'Mucosal vaccination for bacterial respiratory infection', TISSUE ANTIGENS, Melbourne, AUSTRALIA (2005)
2004 Clancy RL, Pang GT, Yu Jun D, Elahi S, Dunkley ML, 'Allergy and Clinical Immunology International: journal of the World Allergy Organization', John Bienenstock, Johannes Ring, Alkis G. Togias, Unknown (2004) [E1]
2003 Clancy R, Pang G, Yu DJ, Elahi S, Dunkley M, 'The management of mucosal dysregulation using Lactobacillus acidophilus (Lavri-1)', ALLERGY FRONTIERS AND FUTURES, Southampton, BERMUDA (2003)
1996 Clancy RL, Pang GT, Dunkley ML, Grissell T, 'Peyer's patch driven protection against influenza using a biomembrane carrier system', OPTIONS FOR THE CONTROL OF INFLUENZA III, CAIRNS, AUSTRALIA (1996)
1995 CRIPPS AW, DUNKLEY ML, CLANCY RL, WALLACE F, BURET A, TAYLOR DC, 'An animal model to study the mechanisms of immunity induced in the respiratory tract by intestinal immunization', ADVANCES IN MUCOSAL IMMUNOLOGY, PTS A AND B, PRAGUE, CZECH REPUBLIC (1995)
Citations Scopus - 6Web of Science - 5
1995 CRIPPS AW, DUNKLEY ML, TAYLOR DC, COUSINS S, CLANCY RL, 'Immunity to Pseudomonas aeruginosa induced by OprF following intestinal immunization', ADVANCES IN MUCOSAL IMMUNOLOGY, PTS A AND B, PRAGUE, CZECH REPUBLIC (1995)
Citations Scopus - 6Web of Science - 4
1995 BURET A, DUNKLEY M, CLANCY RL, CRIPPS AW, 'The protective role of pulmonary neutrophils in rats intestinally immunized with Pseudomonas aeruginosa', ADVANCES IN MUCOSAL IMMUNOLOGY, PTS A AND B, PRAGUE, CZECH REPUBLIC (1995)
Citations Scopus - 4Web of Science - 3
1995 DUNKLEY ML, CRIPPS AW, CLANCY RL, 'Immunity to respiratory Pseudomonas aeruginosa infection: P-aeruginosa -specific T cells arising after intestinal immunization', ADVANCES IN MUCOSAL IMMUNOLOGY, PTS A AND B, PRAGUE, CZECH REPUBLIC (1995)
Citations Scopus - 6Web of Science - 6
1995 DUNKLEY ML, CRIPPS AW, REINBOTT PW, CLANCY RL, 'Immunity to respiratory Pseudomonas aeruginosa infection: The role of gut-derived T helper cells and immune serum', ADVANCES IN MUCOSAL IMMUNOLOGY, PTS A AND B, PRAGUE, CZECH REPUBLIC (1995)
Citations Scopus - 13Web of Science - 11
1993 BURET A, DUNKLEY ML, PANG G, COUCH L, CRIPPS AW, 'MACROPHAGE-MEDIATED PULMONARY IMMUNITY TO PSEUDOMONAS-AERUGINOSA (PA) IN INTESTINALLY IMMUNIZED RATS', JOURNAL OF LEUKOCYTE BIOLOGY (1993)
1993 WILSON NR, DUNKLEY M, BURET A, YOUNG B, CRIPPS AW, 'LUNG HISTOLOGY IN INTESTINALLY IMMUNIZED RATS AFTER INTRATRACHEAL CHALLENGE WITH LIVE PSEUDOMONAS-AERUGINOSA', JOURNAL OF LEUKOCYTE BIOLOGY (1993)
Show 18 more conferences

Patent (2 outputs)

Year Citation Altmetrics Link
2006 Cripps A, Kyd J, Clancy R, Dunkley M, Antigenic composition of a Pseudomonas aeruginosa (2006) [I1]
2005 Dunkley ML, A vaccine formulated for administration to mucosa of the lungs (2005) [I2]
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Grants and Funding

Summary

Number of grants 16
Total funding $789,755

Click on a grant title below to expand the full details for that specific grant.


20071 grants / $20,000

Elucidation of the association between Haemophilus influenzae infection and neutrophilic asthma.$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Phil Hansbro, Professor Jodie Simpson, Laureate Professor Paul Foster, Conjoint Professor Margaret Dunkley
Scheme Project Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187206
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20041 grants / $100,000

Vaccine for oral, vaginal and systemic candidiasis$100,000

Top-up grant for successful BIF grant

Funding body: Biotechnology innovation fund (AUS-industry)

Funding body Biotechnology innovation fund (AUS-industry)
Scheme Unknown
Role Lead
Funding Start 2004
Funding Finish 2004
GNo
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON N

20031 grants / $100,000

Therapeutic Oral vaccine for Bronchitis$100,000

Top-up grant for successful BIF grant

Funding body: DSRD

Funding body DSRD
Scheme Unknown
Role Lead
Funding Start 2003
Funding Finish 2004
GNo
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON N

20021 grants / $10,000

Effects of early life exposure to bacteria on resistance to respiratory infection in adulthood$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Deborah Hodgson, Conjoint Professor Margaret Dunkley
Scheme Project Grant
Role Investigator
Funding Start 2002
Funding Finish 2002
GNo G0181265
Type Of Funding Internal
Category INTE
UON Y

20011 grants / $12,000

Evaluation of soluble H. influenzae and P. aeruginosa antigen preparations for protection against respiratory infection.$12,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Margaret Dunkley
Scheme Project Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0180032
Type Of Funding Internal
Category INTE
UON Y

20001 grants / $2,400

Options for the control of influenza IV Hersonissos, Crete, Greece 23-28 September 2000.$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Margaret Dunkley
Scheme Travel Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0179831
Type Of Funding Internal
Category INTE
UON Y

19991 grants / $1,138

29th Annual Conference of the Australasian Society for Immunology Dunedin, New Zealand.$1,138

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Margaret Dunkley
Scheme Travel Grant
Role Lead
Funding Start 1999
Funding Finish 1999
GNo G0179078
Type Of Funding Internal
Category INTE
UON Y

19982 grants / $217,556

Dual influenza/bacteria respiratory infection - effect on the host immune response$200,556

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Margaret Dunkley, Emeritus Professor Robert Clancy
Scheme Project Grant
Role Lead
Funding Start 1998
Funding Finish 2000
GNo G0177162
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Testing the efficacy of an oral Pseudomonas aeruginosa vaccine in the Cystic Fibrosis mouse.$17,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Margaret Dunkley
Scheme Project Grant
Role Lead
Funding Start 1998
Funding Finish 1998
GNo G0177218
Type Of Funding Internal
Category INTE
UON Y

19973 grants / $137,193

Bacterial respiratory infection - immune elimination and viral interaction$62,193

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Margaret Dunkley, Assoc. Prof A Cripps, Emeritus Professor Robert Clancy
Scheme Project Grant
Role Lead
Funding Start 1997
Funding Finish 1997
GNo G0176232
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

EPICS Elite Flow Cytometer$60,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Kenneth Beagley, Professor Gordon Burns, Conjoint Professor Margaret Dunkley, Emeritus Professor Robert Clancy
Scheme Equipment Grant
Role Investigator
Funding Start 1997
Funding Finish 1997
GNo G0176352
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Is immunisation protective in an immunocompromised state?$15,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Conjoint Professor Kenneth Beagley, Conjoint Professor Margaret Dunkley, Conjoint Associate Professor Michael Boyle
Scheme Small Grant
Role Investigator
Funding Start 1997
Funding Finish 1997
GNo G0176714
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

19961 grants / $12,000

Determination of an immune pathogenesis for recurrent thrush in women$12,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Robert Clancy, Dr Gerald Pang, Conjoint Professor Margaret Dunkley
Scheme Project Grant
Role Investigator
Funding Start 1996
Funding Finish 1996
GNo G0175802
Type Of Funding Internal
Category INTE
UON Y

19951 grants / $1,466

8th Intern. Congress of Mucosal Immunology, USA, 16-20 July$1,466

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Margaret Dunkley
Scheme Travel Grant
Role Lead
Funding Start 1995
Funding Finish 1995
GNo G0176856
Type Of Funding Internal
Category INTE
UON Y

19942 grants / $176,002

94,95,96 GRANT. Mucosal immunity to pathogenic bacteria in the lung.$174,282

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Assoc. Prof A Cripps, Conjoint Professor Margaret Dunkley, Emeritus Professor Robert Clancy
Scheme Project Grant
Role Investigator
Funding Start 1994
Funding Finish 1995
GNo G0173012
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

American Lung Assoc/American Thoracic Soc Int Conference - Boston - 21-25 May 1994$1,720

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Margaret Dunkley
Scheme Travel Grant
Role Lead
Funding Start 1994
Funding Finish 1994
GNo G0175051
Type Of Funding Internal
Category INTE
UON Y
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Research Supervision

Number of supervisions

Completed6
Current0

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2008 PhD A Journey Past the Sun - Group Art Psychotherapy for People with Melanoma: An Investigation Using Narrative and Immunological and Psychosocial Measures PhD (Behavioural Science), Faculty of Health and Medicine, The University of Newcastle Principal Supervisor
2006 Honours Haemophilus influenzae in neutrophilic asthma model (Ama-Tawiah Essilfie) Microbiology, University of Newcastle Principal Supervisor
2002 Honours Evaluation of soluble Pseudomonas aeruginosa antigen preparations for protection against respiratory infection (Angela Ferguson) Microbiology, University of Newcastle Sole Supervisor
2001 PhD Pseudomonas aeruginosa: Development of a mucosal vaccine for respiratory infection (Linda Thomas) Microbiology, University of Canberra Co-Supervisor
1998 Honours Host defence mechanisms in respiratory Pseudomonas aeruginosa infection (Daphne Sawlwin) Microbiology, University of Newcastle Sole Supervisor
1998 Honours The role of antibody in protection against acute respiratory infection with Pseudomonas aeruginosa (Amanda McCue) Microbiology, University of Newcastle Sole Supervisor
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Conjoint Professor Margaret Dunkley

Position

Conjoint Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Immunology and Microbiology

Contact Details

Email margaret.dunkley@newcastle.edu.au
Phone 02 40420233
Fax NIL

Office

Room HMRI 2416
Building HMRI building
Location HMRI, Lot 1 Kookaburra Circuit, New Lambton Heights, NSW 2305

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