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Dr Karen Mate

Senior Lecturer

School of Biomedical Sciences and Pharmacy (Human Physiology)

Career Summary

Biography

Research Expertise
* Gamete maturation * Fertilization * Reproductive technologies * Contraception * Dementia

Teaching Expertise


Administrative Expertise


Collaborations
Gamete maturation, Fertilization, Reproductive technologies, Contraception, Dementia

Qualifications

  • PhD, University of Newcastle
  • Bachelor of Science (Honours), University of Newcastle

Keywords

  • Biological Science
  • Clinical Science
  • Contraception
  • Fertilization
  • Paediatrics
  • Reproductive Medicine

Fields of Research

Code Description Percentage
111499 Paediatrics and Reproductive Medicine not elsewhere classified 65
069999 Biological Sciences not elsewhere classified 35

Professional Experience

UON Appointment

Title Organisation / Department
Senior Lecturer University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (1 outputs)

Year Citation Altmetrics Link
2012 Mate KE, Rodger JC, Lidbury B, 'Language support for first year human physiology and biology', Sustainable language support practices in science education : Technologies and solutions, IGI Global, Hershey, PA 129-159 (2012) [B1]
Citations Scopus - 1
Co-authors John Rodger

Journal article (53 outputs)

Year Citation Altmetrics Link
2017 Mate KE, Magin PJ, Brodaty H, Stocks NP, Gunn J, Disler PB, et al., 'An evaluation of the additional benefit of population screening for dementia beyond a passive case-finding approach', International Journal of Geriatric Psychiatry, 32 316-323 (2017) [C1]

Copyright © 2016 John Wiley & Sons, Ltd. Objective: General practitioners (GPs) fail to identify more than 50% of dementia cases using the existing passive case-finding app... [more]

Copyright © 2016 John Wiley & Sons, Ltd. Objective: General practitioners (GPs) fail to identify more than 50% of dementia cases using the existing passive case-finding approach. Using data from the ¿Ageing in General Practice¿ study, we sought to establish the additional benefit of screening all patients over the age of 75 for dementia beyond those patients already identified by passive case-finding. Method: Patients were classified as ¿case-finding¿ (n = 425) or ¿screening¿ (n = 1006) based on their answers to four subjective memory related questions or their GP's clinical judgement of their dementia status. Cognitive status of each patient was formally assessed by a research nurse using the Cambridge Cognition Examination (CAMCOG-R). Patients then attended their usual GP for administration of the GP assessment of Cognition (GPCOG) dementia screening instrument, and follow-up care and/or referral as necessary in light of the outcome. Results: The prevalence of dementia was significantly higher in the case-finding group (13.6%) compared to the screening group (4.6%; p < 0.01). The GPCOG had a positive predictive value (PPV) of 61% in the case-finding group and 39% in the screening group; negative predictive value was > 95% in both groups. GPs and their patients both found the GPCOG to be an acceptable cognitive assessment tool. The dementia cases missed via case-finding were younger (p = 0.024) and less cognitively impaired (p = 0.020) than those detected. Conclusion: There is a very limited benefit of screening for dementia, as most people with dementia could be detected using a case-finding approach, and considerable potential for social and economic harm because of the low PPV associated with screening.

DOI 10.1002/gps.4466
Co-authors Parker Magin, Dimity Pond
2016 Brodaty H, Connors MH, Loy C, Teixeira-Pinto A, Stocks N, Gunn J, et al., 'Screening for Dementia in Primary Care: A Comparison of the GPCOG and the MMSE', Dementia and Geriatric Cognitive Disorders, 42 323-330 (2016) [C1]

© 2016 S. Karger AG, Basel. Background/Aims: The General Practitioner Assessment of Cognition (GPCOG) is a brief cognitive test. This study compared the GPCOG to the Mini-Mental ... [more]

© 2016 S. Karger AG, Basel. Background/Aims: The General Practitioner Assessment of Cognition (GPCOG) is a brief cognitive test. This study compared the GPCOG to the Mini-Mental State Examination (MMSE), the most widely used test, in terms of their ability to detect likely dementia in primary care. Methods: General practitioners across three states in Australia recruited 2,028 elderly patients from the community. A research nurse administered the GPCOG and the MMSE, as well as the Cambridge Examination for Mental Disorders of the Elderly Cognitive Scale-Revised that we used to define likely dementia. Results: Overall, the GPCOG and the MMSE were similarly effective at detecting likely dementia. The GPCOG, however, had a higher sensitivity than the MMSE when using published cutpoints. Conclusion: The GPCOG is an effective screening tool for dementia in primary care. It appears to be a viable alternative to the MMSE, whilst also requiring less time to administer.

DOI 10.1159/000450992
Co-authors Dimity Pond
2016 Magin PJ, Morgan S, Tapley A, McCowan C, Parkinson L, Henderson KM, et al., 'Anticholinergic medicines in an older primary care population: a cross-sectional analysis of medicines¿ levels of anticholinergic activity and clinical indications', Journal of Clinical Pharmacy and Therapeutics, 41 486-492 (2016) [C1]

© 2016 John Wiley &amp; Sons Ltd What is known and objectives: Adverse clinical outcomes have been associated with cumulative anticholinergic burden (to which low-potency as we... [more]

© 2016 John Wiley & Sons Ltd What is known and objectives: Adverse clinical outcomes have been associated with cumulative anticholinergic burden (to which low-potency as well as high-potency anticholinergic medicines contribute). The clinical indications for which anticholinergic medicines are prescribed (and thus the ¿phenotype¿ of patients with anticholinergic burden) have not been established. We sought to establish the overall prevalence of prescribing of anticholinergic medicines, the prevalence of prescribing of low-, medium- and high-potency anticholinergic medicines, and the clinical indications for which the medicines were prescribed in an older primary care population. Methods: This was a cross-sectional analysis of a cohort study of Australian early-career general practitioners¿ (GPs¿) clinical consultations ¿ the Registrar Clinical Encounters in Training (ReCEnT) study. In ReCEnT, GPs collect detailed data (including medicines prescribed and their clinical indication) for 60 consecutive patients, on up to three occasions 6 months apart. Anticholinergic medicines were categorized as levels 1 (low-potency) to 3 (high-potency) using the Anticholinergic Drug Scale (ADS). Results: During 2010¿2014, 879 early-career GPs (across five of Australia's six states) conducted 20 555 consultations with patients aged 65 years or older, representing 35 506 problems/diagnoses. Anticholinergic medicines were prescribed in 10·4% [95% CIs 9·5¿10·5] of consultations. Of the total anticholinergic load of prescribed medicines (¿community anticholinergic load¿) 72·7% [95% CIs 71·0¿74·3] was contributed by Level 1 medicines, 0·8% [95% CIs 0·5¿1·3] by Level 2 medicines and 26·5% [95% CIs 24·8¿28·1] by Level 3 medicines. Cardiac (40·0%), Musculoskeletal (16·9%) and Respiratory (10·6%) were the most common indications associated with Level 1 anticholinergic prescription. For Level 2 and 3 medicines (combined data), Psychological (16·1%), Neurological (16·1%), Musculoskeletal (15·7%) and Urological (11·1%) indications were most common. What is new and conclusion: Anticholinergic medicines are frequently prescribed in Australian general practice, and the majority of the ¿community¿ anticholinergic burden is contributed by ¿low¿-anticholinergic potency medicines whose anticholinergic effects may be largely ¿invisible¿ to prescribing GPs. Furthermore, the clinical ¿phenotype¿ of the patient with high anticholinergic burden may be very different to common stereotypes (patients with urological, psychological or neurological problems), potentially making recognition of risk of anticholinergic adverse effects additionally problematic for GPs.

DOI 10.1111/jcpt.12413
Citations Scopus - 2Web of Science - 2
Co-authors Dimity Pond, L Parkinson, Parker Magin
2015 Mate KE, Kerr KP, Pond D, Williams EJ, Marley J, Disler P, et al., 'Impact of Multiple Low-Level Anticholinergic Medications on Anticholinergic Load of Community-Dwelling Elderly With and Without Dementia', Drugs and Aging, 32 159-167 (2015) [C1]
DOI 10.1007/s40266-014-0230-0
Citations Scopus - 9Web of Science - 8
Co-authors Parker Magin, Dimity Pond, Karen Kerr
2014 Kerr KP, Mate KE, Magin PJ, Marley J, Stocks NP, Disler P, Pond CD, 'The prevalence of co-prescription of clinically relevant CYP enzyme inhibitor and substrate drugs in community-dwelling elderly Australians', JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 39 383-389 (2014) [C1]
DOI 10.1111/jcpt.12163
Citations Scopus - 7Web of Science - 6
Co-authors Karen Kerr, Parker Magin, Dimity Pond
2014 Evans S, Berry C, Mate KE, 'A case-based interactive format for very large undergraduate classes in introductory bioscience supports and improves student learning', International Journal of Innovation in Science and Mathematics Education, 22 1-10 (2014) [C1]

A sound understanding of bioscience and an ability to use that knowledge in solving complex problems is required for the development of proficient health practitioners. This paper... [more]

A sound understanding of bioscience and an ability to use that knowledge in solving complex problems is required for the development of proficient health practitioners. This paper describes the continuing development of a bioscience course designed specifically for this purpose; it uses a problem based approach to teach the skill of applying knowledge of basic scientific concepts to clinical case scenarios. Face to face teaching hours were divided equally between lectures (to introduce inexperienced learners to the material) and problem based interactive tutorials (to model and practice the skill of applying basic knowledge to clinical case scenarios). The difficulty of finding sufficient teaching staff with a strong scientific and clinical background was addressed by using a large group interactive format for tutorials, along with the use of an electronic audience response system. This approach resulted in an increase of both academic performance and student satisfaction, with no diminution of the perceived level of support provided to students.

2014 Mate K, Riveros C, Weidenhofer J, Goldie B, Scott J, Moscato P, et al., 'Strategies for Enhancing Communication between Students, Academics and Researchers participating in Large-Scale Undergraduate Research Projects', International Journal of Innovation in Science and Mathematics Education, 22 14-29 (2014) [C1]
Co-authors Judith Weidenhofer, Carlos Riveros, Liz Milward, Pablo Moscato
2013 Pond CD, Mate KE, Phillips J, Stocks NP, Magin PJ, Weaver N, Brodaty H, 'Predictors of agreement between general practitioner detection of dementia and the revised Cambridge Cognitive Assessment (CAMCOG-R)', INTERNATIONAL PSYCHOGERIATRICS, 25 1639-1647 (2013) [C1]
DOI 10.1017/S1041610213000884
Citations Scopus - 5Web of Science - 5
Co-authors Natasha Weaver, Dimity Pond, Parker Magin
2013 Mate K, Sim A, Weidenhofer J, Milward L, Scott J, 'Investigation of the human disease osteogenesis imperfecta: A research-based introduction to concepts and skills in biomolecular analysis', Biochemistry & Molecular Biology Education, 41 103-109 (2013) [C1]
DOI 10.1002/bmb.20672
Citations Scopus - 1
Co-authors Liz Milward, Alistair Sim, Judith Weidenhofer
2012 Pond CD, Brodaty H, Stocks NP, Gunn J, Marley JE, Disler P, et al., 'Ageing in general practice (AGP) trial: A cluster randomised trial to examine the effectiveness of peer education on GP diagnostic assessment and management of dementia', BMC Family Practice, 13 1-9 (2012) [C3]
Citations Scopus - 13Web of Science - 12
Co-authors Graeme Horton, Parker Magin, Dimity Pond
2012 Mate KE, Pond CD, Magin PJ, Goode SM, McElduff P, Stocks NP, 'Diagnosis and disclosure of a memory problem is associated with quality of life in community based older Australians with dementia', International Psychogeriatrics, 24 1962-1971 (2012) [C1]
Citations Scopus - 8Web of Science - 8
Co-authors Patrick Mcelduff, Parker Magin, Dimity Pond
2011 Zhang F, Lidbury BA, Richardson AM, Yates BF, Gardiner MG, Bridgeman AJ, et al., 'Sustainable language support practices in science education: Technologies and solutions', Sustainable Language Support Practices in Science Education: Technologies and Solutions, 1-246 (2011)

The effective communication of science through language, including reading, writing, listening, speaking, and visual representation, is an essential part of scientific learning, u... [more]

The effective communication of science through language, including reading, writing, listening, speaking, and visual representation, is an essential part of scientific learning, understanding, and practice. Language is the medium by which scientific reasoning occurs, whether be it formal language or symbolic representations of scientific phenomena. Sustainable Language Support Practices in Science Education: Technologies and Solutions presents cases on the results of a study done in Australia on first-year university students and the impact of new techniques of language acquisition on science education. The project covered biology, chemistry, and physics. Nearly 3,400 students were involved in the project, drawn from the University of Canberra, the University of Technology-Sydney, the University of Sydney, the University of Tasmania, and the University of Newcastle in Australia. This book serves as the latest research available on meta-cognitive assessment and language needs for a diverse student body; it is a vital resource for academics and practitioners designing and implementing science education around the world today. © 2012 by IGI Global. All rights reserved.

DOI 10.4018/978-1-61350-062-0
Co-authors John Rodger
2010 Pond CD, Brodaty H, Gunn J, Stocks N, Disler P, Mate KE, et al., 'GP identification of dementia: effect of gender, age and size of practice', Alzheimer's & Dementia, 6 S364-S365 (2010) [C3]
Co-authors Dimity Pond, Parker Magin
2009 Kitchener AL, Harman A, Kay DJ, McCartney CA, Mate KE, Rodger JC, 'Immunocontraception of Eastern Grey kangaroos (Macropus giganteus) with recombinant brushtail possum (Trichosurus vulpecula) ZP3 protein', Journal of Reproductive Immunology, 79 156-162 (2009) [C1]
DOI 10.1016/j.jri.2008.10.004
Citations Scopus - 16Web of Science - 10
Co-authors John Rodger
2009 Kitchener AL, Kay DJ, Walters B, Menkhorst P, McCartney CA, Buist JM, et al., 'The immune response and fertility of koalas (Phascolarctos cinereus) immunised with porcine zonae pellucidae or recombinant brushtail possum ZP3 protein', Journal of Reproductive Immunology, 82 40-47 (2009) [C1]
DOI 10.1016/j.jri.2009.07.001
Citations Scopus - 14Web of Science - 10
Co-authors John Rodger
2008 Czarny NA, Mate KE, Rodger JC, 'Acrosome stability in the spermatoza of dasyurid marsupials', Reproduction, Fertility and Development, 20 295-302 (2008) [C1]
DOI 10.1071/RD07178
Citations Scopus - 8Web of Science - 7
Co-authors John Rodger
2007 McCartney CA, Harris MS, Rodger JC, Mate KE, 'Towards a ZP-Based contraceptive for marsupials: Comparative analysis and developmental expression of marsupial ZP genes', Molecular Reproduction and Development, 74 1581-1589 (2007) [C1]
DOI 10.1002/mrd.20707
Citations Scopus - 3Web of Science - 3
Co-authors Merrilee Harris, John Rodger
2004 Magarey GM, Mate KE, 'Comparison of glucose metabolism in vivo- and in vitro-matured tammar wallaby oocytes and its relationship to developmental potential following intracytoplasmic sperm injection', Reproduction Fertility and Development, 16 617-623 (2004) [C1]
DOI 10.1071/RD03062
Citations Scopus - 2Web of Science - 2
2004 Sidhu KS, Mate KE, Gunasekera T, Veal D, Hetherington L, Baker MA, et al., 'A flow cytometric assay for global estimation of tyrosine phosphorylation associated with capacitation of spermatozoa from two marsupial species, the tammar wallaby (Macropus eugenii) and the brushtail possum (Trichosurus vulpecula)', Reproduction, 127 95-103 (2004) [C1]
DOI 10.1530/rep.1.00073
Citations Scopus - 29Web of Science - 26
Co-authors John Aitken, John Rodger, Mark Baker
2003 Magarey GM, Rodger JC, Buist JM, Mate KE, 'Effects of repeated superovulation and surgical oocyte collection on ovarian response and natural breeding ability of the tammar wallaby (Macropus eugenii)', REPRODUCTION, 125 701-707 (2003) [C1]
Citations Scopus - 11Web of Science - 10
Co-authors John Rodger
2003 Sidhu KS, Mate KE, Molinia FC, Berg DK, Rodger JC, 'Ionic calcium levels in oviduct explant-conditioned media from an Australian marsupial, the brushtail possum (Trichosurus vulpecula) and its relevance to in vitro fertilization', ZYGOTE, 11 285-291 (2003) [C1]
DOI 10.1017/S0967199403002338
Citations Scopus - 8Web of Science - 6
Co-authors John Rodger
2003 Magarey GM, Mate KE, 'Fertilization following intracytoplasmic sperm injection of in vivo and in vitro matured oocytes from an Australian marsupial, the tammar wallaby (Macropus eugenii)', ZYGOTE, 11 339-346 (2003)
DOI 10.1017/S0967199403002430
Citations Scopus - 10Web of Science - 8
2003 Magarey GM, Mate KE, 'Timing and ultrastructure of events following intracytoplasmic sperm injection in a marsupial, the tammar wallaby (Macropus eugenii)', Reproduction Fertility and Development, 15 397-406 (2003) [C1]
DOI 10.1071/RD03033
Citations Scopus - 3Web of Science - 3
2003 Mate KE, Buist JM, Duckworth JA, 'Expression in Escherichia coli and immunological characterization of three zona pellucida proteins (ZP1, ZP2, and ZP3) from a marsupial, the brushtail possum (Trichosurus vulpeecula)', MOLECULAR REPRODUCTION AND DEVELOPMENT, 64 136-143 (2003)
DOI 10.1002/mrd.10240
Citations Scopus - 15Web of Science - 15
2002 Glazier AM, Mate KE, Rodger JC, 'In vitro and in vivo maturation of oocytes from gonadotrophin-treated brushtail possums', MOLECULAR REPRODUCTION AND DEVELOPMENT, 62 504-512 (2002) [C1]
DOI 10.1002/mrd.10154
Citations Scopus - 9Web of Science - 10
Co-authors John Rodger
2000 Mate KE, Sidhu KS, Molinia FC, Glazier AM, Rodger JC, 'Sperm binding and penetration of the zona pellucida in vitro but not sperm-egg fusion in an Australian marsupial, the brushtail possum (Trichosurus vulpecula)', ZYGOTE, 8 189-196 (2000) [C1]
DOI 10.1017/S0967199400000976
Citations Scopus - 23Web of Science - 22
Co-authors John Rodger
1999 Sidhu KS, Mate KE, Molinia FC, Rodger JC, 'Induction of thumbtack sperm during coculture with oviduct epithelial cell monolayers in a marsupial, the brushtail possum (Trichosurus vulpecula)', BIOLOGY OF REPRODUCTION, 61 1356-1361 (1999) [C1]
DOI 10.1095/biolreprod61.5.1356
Citations Scopus - 12Web of Science - 12
Co-authors John Rodger
1999 Mate KE, Buist JM, 'Timing and regulatory aspects of oocyte maturation in vitro in the tammar wallaby (Macropus eugenii)', Reproduction, Fertility and Development, 11 247-254 (1999)

Oocytes from a marsupial, the tammar wallaby (Macropus eugenii), resemble those of eutherian mammals in their ability to resume meiosis in vitro when cultured under suitable condi... [more]

Oocytes from a marsupial, the tammar wallaby (Macropus eugenii), resemble those of eutherian mammals in their ability to resume meiosis in vitro when cultured under suitable conditions. Culture for 42-48 h in Eagle's minimum essential medium (EMEM) supplemented with 10% fetal calf serum, and 10 µg mL -1 porcine luteinizing hormone (pLH) was required in order for oocytes, collected from the large antral follicles ( > 2 mm diameter) of tammar wallabies (primed with 6 mg of porcine follicle stimulating hormone twice daily for four days), to proceed to metaphase II (MII) of meiosis. Under these conditions, chromatin condensation was observed within 4-8 h of culture in 61% of oocytes; metaphase I (MI) chromosomes were observed from 18-30 h of culture (66%); and most oocytes (76%) progressed to MII by 42 h in vitro. The addition of cycloheximide, a protein synthesis inhibitor, at concentrations of 1-100 µg mL -1 , prevented maturation of tammar wallaby oocytes in vitro. This effect was reversible, as oocytes washed free of cycloheximide after 4 h of incubation were able to progress to MII. The addition of cycloheximide to wallaby oocytes at MI of meiosis prevented normal progression to MII suggesting that proteins critical for nuclear maturation are synthesized throughout the maturation process. Genistein, a protein kinase inhibitor decreased maturation of wallaby oocytes in a dose dependent manner. However, the concentration required to significantly inhibit maturation of wallaby oocytes (60 µg mL -1 ) was greater than that required for eutherian species. Most wallaby oocytes were able to undergo germinal vesicle breakdown (GVBD) in the presence of high concentrations of genistein but produced abnormal chromatin configurations and were unable to progress to MII. Future studies will examine whether cytoplasmic changes occur in marsupial oocytes in vitro and their temporal relationship to nuclear maturation.

Citations Scopus - 8
1999 McCartney CA, Mate KE, 'Cloning and characterisation of a zona pellucida 3 cDNA from a marsupial, the brushtail possum Trichosurus vulpecula', ZYGOTE, 7 1-9 (1999)
DOI 10.1017/S0967199499000337
Citations Scopus - 23Web of Science - 41
1999 Mate KE, Buist JM, 'Timing and regulatory aspects of oocyte maturation in vitro in the tammar wallaby (Macropus eugenii)', REPRODUCTION FERTILITY AND DEVELOPMENT, 11 247-254 (1999)
DOI 10.1071/RD99069
Citations Web of Science - 10
1999 Sidhu KS, Mate KE, Molinia FC, Glazier AM, Rodger JC, 'Secretory proteins from the female reproductive tract of the brushtail possum (Trichosurus vulpecula): binding to sperm and effects on sperm survival in vitro', REPRODUCTION FERTILITY AND DEVELOPMENT, 11 329-336 (1999) [C1]
DOI 10.1071/RD00010
Citations Scopus - 8Web of Science - 7
Co-authors John Rodger
1998 Sidhu KS, Mate KE, Rodger JC, 'Sperm-oviduct epithelial cell monolayer co-culture: An in vitro model of sperm-female tract interactions in a marsupial, the tammar wallaby (Macropus eugenii)', Journal of Reproduction and Fertility, 114 55-61 (1998)

Oviduct epithelial cell (OEC) monolayers were prepared from the isthmic and ampullary parts of the oviducts of FSH-primed tammar wallabies. Co-culture experiments found that 50-60... [more]

Oviduct epithelial cell (OEC) monolayers were prepared from the isthmic and ampullary parts of the oviducts of FSH-primed tammar wallabies. Co-culture experiments found that 50-60% of wallaby spermatozoa attached immediately to OEC monolayers, tracheal cell monolayer controls, and the surface of culture dishes with and without Matrigel coating. Spermatozoa were considered to be attached if they remained on the culture surface after rapidly pipetting the co-culture medium five times. The percentages of attached and unattached spermatozoa were calculated from the number of spermatozoa recovered in the agitated supernatant. After 2 h co-culture the percentage of attached spermatozoa rose to 60-80%. After 6 h co-culture the number of spermatozoa attached to OEC monolayers derived from the oviductal isthmus remained high and only a small percentage were recovered in the agitated supernatant (unattached spermatozoa 3.85 ± 0.76%, P = 0.67). However, after 6 h co-culture of spermatozoa with OEC monolayers derived from the ampulla and with the controls the percentage of attached spermatozoa declined significantly (unattached spermatozoa: ampullary monolayer 23.08 ± 4.80%, P < 0.01; tracheal monolayer 23.23 ± 5.18%, P < 0.01; Matrigel 27.23 ± 7.76%, P < 0.01; plastic surface 28.19 ± 5.30%, P < 0.01). After 6 h co-culture with ampullary and isthmic OEC monolayers, the percentage motility of both attached and unattached spermatozoa was maintained at 64.00 ± 1.90% and 56.66 ± 3.18% and 62.00 ± 3.11% and 52.00 ± 2.43%, respectively, and was then maintained at = 35% after 24 h incubation. In the controls, that is, tracheal monolayer and Matrigel, the motility of attached spermatozoa declined rapidly to 48.66 ± 2.15% and 33.63 ± 8.66%, respectively, at 6 h, and all spermatozoa were immotile after 24 h incubation. However, the motility of unattached spermatozoa in the controls (tracheal monolayer and Matrigel) was maintained at 57.33 ± 3.00% and 34.54 ± 9.27%, respectively, until 6 h and then declined rapidly, and all spermatozoa were immotile after 24 h incubation. Co-culture of wallaby spermatozoa with OEC monolayers also induced acrosomal modifications that were followed by acrosomal loss. At 6 h incubation 38.92 ± 3.98% of spermatozoa on ampullary OEC monolayers and 36.50 ± 3.81% spermatozoa on isthmic OEC monolayers had shed their acrosome. Acrosomal loss during co-culture with both isthmic and ampullary OEC monolayers was significantly (P < 0.01) greater than that observed on tracheal epithelial monolayer (24.42 ± 1.90%, P < 0.01), Matrigel (20.70 ± 2.71%, P < 0.01) and plastic (15.54 ± 2.49%, P < 0.01). Co-culturing spermatozoa with OEC monolayers also induced a transformation from streamlined orientation of sperm head and tail to T-shaped (thumbtack) orientation in a small number (10-15%) of motile spermatozoa after 6 h incubation (data not shown). The significance of these results in relation to the role of the oviduct in sperm capacitation is discussed.

Citations Scopus - 8
Co-authors John Rodger
1998 Mate KE, McCartney CA, 'Sequence and analysis of zona pellucida 2 cDNA (ZP2) from a marsupial, the brushtail possum, Trichosurus vulpecula', Molecular Reproduction and Development, 51 322-329 (1998)

All mammalian eggs are surrounded by the zona pellucida, an extracellular coat involved in vital functions during fertilization and early development. The zona pellucida glycoprot... [more]

All mammalian eggs are surrounded by the zona pellucida, an extracellular coat involved in vital functions during fertilization and early development. The zona pellucida glycoproteins are promising antigenic targets for development of contraceptive vaccines to control pest populations of marsupials in Australia and New Zealand. Our current understanding of the function of the zona pellucida glycoproteins is based almost entirely on the mouse and may not be representative of gamete interactions in all eutherian or marsupial mammals. This study reports the isolation and characterization of the ZP2 gene from the brushtail possum (Trichosurus vulpecula). The brushtail possum ZP2 mRNA is 2,182 nucleotides long with an open reading frame coding for a polypeptide chain of 712 amino acids with a molecular mass of 79,542 d. The deduced amino acid sequence of possum ZP2 is 48 to 55% identical to that of eutherian mammals. It shares several structural characteristics including N-linked glycosylation sites, location and number of cysteine residues, and hydropathy profile. The brushtail possum ZP2 gene is expressed exclusively in the ovary. Further studies are planned to elucidate the specific site of ZP2 expression within the ovary and its function during fertilization in marsupials.

DOI 10.1002/(SICI)1098-2795(199811)51:3&amp;lt;322::AID-MRD12&amp;gt;3.0.CO;2-4
Citations Scopus - 19
1998 Mate KE, McCartney CA, 'Sequence and analysis of the zona pellucida 2 gene (ZP2), from a marsupial, the brushtail possum, Trichosurus vulpecula.', BIOLOGY OF REPRODUCTION, 58 187-187 (1998)
1998 Sidhu KS, Mate KE, Rodger JC, 'Sperm-oviduct epithelial cell monolayer co-culture: an in vitro model of sperm-female tract interactions in a marsupial, the tammar wallaby (Macropus eugenii)', JOURNAL OF REPRODUCTION AND FERTILITY, 114 55-61 (1998)
Citations Scopus - 7Web of Science - 11
Co-authors John Rodger
1998 Mate KE, Molinia FC, Rodger JC, 'Manipulation of the fertility of marsupials for conservation of endangered species and control of over-abundant populations', ANIMAL REPRODUCTION SCIENCE, 53 65-76 (1998)
DOI 10.1016/S0378-4320(98)00127-4
Citations Scopus - 19Web of Science - 19
Co-authors John Rodger
1998 Mate KE, 'Timing of zona pellucida formation in the tammar wallaby (Macropus eugenii) and brushtail possum (Trichosurus vulpecula)', ANIMAL REPRODUCTION SCIENCE, 53 237-252 (1998)
DOI 10.1016/S0378-4320(98)00116-X
Citations Scopus - 13Web of Science - 11
1998 Mate KE, McCartney CA, 'Sequence and analysis of zona pellucida 2 cDNA (ZP2) from a marsupial, the brushtail possum, Trichosurus vulpecula', MOLECULAR REPRODUCTION AND DEVELOPMENT, 51 322-329 (1998)
DOI 10.1002/(SICI)1098-2795(199811)51:3&lt;322::AID-MRD12&gt;3.0.CO;2-4
Citations Web of Science - 18
1996 Mate KE, 'Cytoplasmic maturation of the marsupial oocyte during the periovulatory period', REPRODUCTION FERTILITY AND DEVELOPMENT, 8 509-519 (1996)
DOI 10.1071/RD9960509
Citations Scopus - 25Web of Science - 23
1996 Mate KE, Rodger JC, 'Capacitation and the acrosome reaction in marsupial spermatozoa', REPRODUCTION FERTILITY AND DEVELOPMENT, 8 595-603 (1996)
DOI 10.1071/RD9960595
Citations Scopus - 17Web of Science - 16
Co-authors John Rodger
1995 DANDEKAR P, MATE KE, TALBOT P, 'PERIVITELLINE SPACE OF MARSUPIAL OOCYTES - EXTRACELLULAR-MATRIX OF THE UNFERTILIZED OOCYTE AND FORMATION OF A CORTICAL GRANULE ENVELOPE FOLLOWING THE CORTICAL REACTION', MOLECULAR REPRODUCTION AND DEVELOPMENT, 41 368-373 (1995)
DOI 10.1002/mrd.1080410313
Citations Scopus - 24Web of Science - 24
1994 MATE KE, KOSOWER NS, WHITE IG, RODGER JC, 'FLUORESCENT LOCALIZATION OF THIOLS AND DISULFIDES IN MARSUPIAL SPERMATOZOA BY BROMOBIMANE LABELING', MOLECULAR REPRODUCTION AND DEVELOPMENT, 37 318-325 (1994)
DOI 10.1002/mrd.1080370311
Citations Scopus - 22Web of Science - 20
Co-authors John Rodger
1994 MATE KE, ROBINSON ES, VANDEBERG JL, PEDERSEN RA, 'TIMETABLE OF IN-VIVO EMBRYONIC-DEVELOPMENT IN THE GREY SHORT-TAILED OPOSSUM (MONODELPHIS-DOMESTICA)', MOLECULAR REPRODUCTION AND DEVELOPMENT, 39 365-374 (1994)
Citations Scopus - 59Web of Science - 54
1993 SISTINA Y, LIN M, MATE KE, RODGER JC, 'INDUCTION OF THE MARSUPIAL SPERM ACROSOME REACTION IN-VITRO BY TREATMENT WITH DIACYLGLYCEROLS', JOURNAL OF REPRODUCTION AND FERTILITY, 99 335-341 (1993)
Citations Scopus - 16Web of Science - 16
Co-authors John Rodger
1993 MATE KE, RODGER JC, 'ROLE OF DIACYLGLYCEROLS AND CALCIUM IN THE MARSUPIAL ACROSOME REACTION', JOURNAL OF REPRODUCTION AND FERTILITY, 99 367-373 (1993)
Citations Scopus - 5Web of Science - 5
Co-authors John Rodger
1993 SISTINA Y, LIN MJ, MATE KE, ROBINSON ES, RODGER JC, 'THE UNIQUE STABILITY OF THE MARSUPIAL SPERM ACROSOMAL MEMBRANES EXAMINED BY UNPROTECTED FREEZE-THAWING AND TREATMENT WITH THE DETERGENT TRITON-X-100', REPRODUCTION FERTILITY AND DEVELOPMENT, 5 1-14 (1993)
DOI 10.1071/RD9930001
Citations Scopus - 25Web of Science - 27
Co-authors John Rodger
1993 RODGER JC, COUSINS SJ, MATE KE, HINDS LA, 'OVARIAN-FUNCTION AND ITS MANIPULATION IN THE TAMMAR WALLABY, MACROPUS-EUGENII', REPRODUCTION FERTILITY AND DEVELOPMENT, 5 27-38 (1993)
DOI 10.1071/RD9930027
Citations Scopus - 16Web of Science - 15
Co-authors John Rodger
1993 MATE KE, RODGER JC, 'INVITRO MATURATION OF OOCYTES FROM A MARSUPIAL, THE TAMMAR WALLABY (MACROPUS-EUGENII)', MOLECULAR REPRODUCTION AND DEVELOPMENT, 34 329-336 (1993)
DOI 10.1002/mrd.1080340314
Citations Scopus - 13Web of Science - 14
Co-authors John Rodger
1992 MATE KE, GILES I, RODGER JC, 'EVIDENCE THAT CORTICAL GRANULE FORMATION IS A PERIOVULATORY EVENT IN MARSUPIALS', JOURNAL OF REPRODUCTION AND FERTILITY, 95 719-728 (1992)
Citations Scopus - 28Web of Science - 30
Co-authors John Rodger
1992 RODGER JC, GILES I, MATE KE, 'UNEXPECTED OOCYTE GROWTH AFTER FOLLICULAR ANTRUM FORMATION IN 4 MARSUPIAL SPECIES', JOURNAL OF REPRODUCTION AND FERTILITY, 96 755-763 (1992)
Citations Scopus - 26Web of Science - 23
Co-authors John Rodger
1991 MATE KE, RODGER JC, 'STABILITY OF THE ACROSOME OF THE BRUSH-TAILED POSSUM (TRICHOSURUS-VULPECULA) AND TAMMAR WALLABY (MACROPUS-EUGENII) INVITRO AND AFTER EXPOSURE TO CONDITIONS AND AGENTS KNOWN TO CAUSE CAPACITATION OR ACROSOME REACTION OF EUTHERIAN SPERMATOZOA', JOURNAL OF REPRODUCTION AND FERTILITY, 91 41-48 (1991)
Citations Scopus - 42Web of Science - 50
Co-authors John Rodger
1991 RODGER JC, COUSINS SJ, MATE KE, 'A SIMPLE GLYCEROL-BASED FREEZING PROTOCOL FOR THE SEMEN OF A MARSUPIAL TRICHOSURUS-VULPECULA, THE COMMON BRUSHTAIL POSSUM', REPRODUCTION FERTILITY AND DEVELOPMENT, 3 119-125 (1991)
DOI 10.1071/RD9910119
Citations Scopus - 26Web of Science - 27
Co-authors John Rodger
1988 RODGER JC, MATE KE, 'A PMSG GNRH METHOD FOR THE SUPEROVULATION OF THE MONOVULATORY BRUSH-TAILED POSSUM (TRICHOSURUS-VULPECULA)', JOURNAL OF REPRODUCTION AND FERTILITY, 83 885-891 (1988)
Citations Scopus - 40Web of Science - 42
Co-authors John Rodger
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Conference (23 outputs)

Year Citation Altmetrics Link
2016 Biswas M, Daneshi N, Dias T, Rasiah R, Mate K, Holliday E, et al., 'Prevalence of drug and gene interactions for cardiovascular drugs in older Australians', Sydney (2016)
Co-authors Liz Holliday, Rohan Rasiah, Liz Milward, John Attia, Karen Kerr, David Newby
2016 Kerr KP, Mate KE, Barnett M, Pond D, Magin P, 'The effect of anticholinergic load over time in community-dwelling elderly Australians', Melbourne (2016)
Co-authors Karen Kerr, Parker Magin
2015 Biswas M, Daneshi N, Rasiah R, Mate K, Holliday E, Attia J, et al., 'Prevalence of cytochrome P450 (CYP) substrate-inhibitor interactions in patients on clopidogrel and frequency of CYP2C19*2 gene variants', Australasian Pharmaceutical Science Association (APSA)- Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Joint Scientific Meeting. Book of Poster Abstracts, Hobart, Tasmania (2015) [E3]
Co-authors Rohan Rasiah, Karen Kerr, Liz Milward, John Attia, Liz Holliday
2015 Kerr KP, Mate KE, Prince B, Pond D, Magin PJ, 'Effects of general practitioner education on the prescription of anticholinergic medications.', Hong Kong (2015) [E3]
Co-authors Parker Magin, Karen Kerr, Dimity Pond
2014 Kerr KP, Mate KE, Williams E, Pond D, Magin PJ, 'Factors associated with a high anticholinergic burden in elderly Australians with and without dementia', ASCEPT-MPGPCR Joint Scientific Meeting, Melbourne (2014) [E3]
Co-authors Dimity Pond, Parker Magin, Karen Kerr
2013 Pond C, Magin P, Brodaty H, Gunn J, Stocks N, Phllips J, et al., 'Improving GP detection and management of dementia: outcomes of an RCT', 2013 Primary Health Care Research Conference: Program & Abstracts, Sydney (2013) [E3]
Co-authors Dimity Pond
2013 Kerr KP, Mate KE, Williams E, Pond D, Magin PJ, 'Anticholinergic load in community dwelling elderly Australians with dementia', ASCEPT Annual Scientific Meeting, Melbourne, Vic (2013) [E3]
Co-authors Parker Magin, Karen Kerr, Dimity Pond
2013 Evans SM, Berry C, Mate K, 'Targeting the Bioscience-practice nexus to facilitate learning in first year nursing students', Proceedings of The Australian Conference on Science and Mathematics Education, Canberra, ACT (2013)
2012 Pond CD, Brodaty H, Stocks NP, Gunn J, Disler P, Paterson NE, et al., 'Improving general practitioner identification rates of dementia: The effectiveness of medical detailing plus audit', IPA 2012: International Psychigeriatric Association International Meeting Abstracts, Cairns (2012) [E3]
Co-authors Dimity Pond, Parker Magin, Natasha Weaver
2012 Kerr KP, Mate KE, Pond CD, Magin PJ, Stocks N, Marley JE, Disler P, 'Prescribing in the elderly - cytochrome P450 (CYP) enzyme inhibitors and substrates', ASCEPT-APSA 2012 Oral Abstracts, Sydney, NSW (2012) [E3]
Co-authors Dimity Pond, Parker Magin, Karen Kerr
2012 Mate KE, Kerr KP, Pond CD, Magin PJ, 'Potentially inappropriate medications in the elderly - A case study', Symposium Program. Interprofessional Education for Quality Use of Medicines, Newcastle Beach, NSW (2012) [E3]
Co-authors Karen Kerr, Parker Magin, Dimity Pond
2012 Kerr KP, Mate KE, Pond CD, Magin PJ, 'An ACE inhibitor and a Sartan - Is there a place for this combination? A real-life case study for students in the health professions', Symposium Program. Interprofessional Education for Quality Use of Medicines, Newcastle Beach, NSW (2012) [E3]
Co-authors Dimity Pond, Karen Kerr, Parker Magin
2012 Pond CD, Mate KE, Phillips J, Goode SM, Paterson NE, Magin PJ, et al., 'A particularly difficult diagnosis to make: Factors that facilitate GP diagnosis of dementia', 2012 Primary Health Care Research Conference: Program & Abstracts, Canberra, ACT (2012) [E3]
Co-authors Dimity Pond, Parker Magin
2011 Pond CD, Brodaty H, Stocks N, Paterson NE, Magin PJ, Gunn J, et al., 'The attitudes of Australian general practitioners to breaking news of dementia: A qualitative and quantitative exploration', Alzheimer's and Dementia, Paris, France (2011) [E3]
Co-authors Dimity Pond, Parker Magin
2011 Pond CD, Goode SM, Mate KE, Magin PJ, Brodaty H, Brodaty H, Marley JE, 'GP evaluation of a dementia education project', 2011 PHC Research Conference Abstracts, Brisbane, QLD (2011) [E3]
Co-authors Dimity Pond, Parker Magin
2010 Mate KE, Pond CD, Swain J, Goode SM, Magin PJ, 'The relationship of GP diagnosis of dementia with patient depression and quality of life measures', 2010 Primary Health Care Research Conference: Program & Abstracts, Darwin, NT (2010) [E3]
Co-authors Parker Magin, Dimity Pond
2010 Pond CD, Mate KE, Swain J, Goode SM, Magin PJ, Brodaty H, et al., 'Dementia detection in general practice: Clinical diagnosis or brief screening instrument?', 2010 Primary Health Care Research Conference: Program & Abstracts, Darwin, NT (2010) [E3]
Co-authors Parker Magin, Dimity Pond
2009 Pond CD, Swain J, Mate KE, 'Dementia in general practice', Alzheimer's and Dementia, Vienna, Austria (2009) [E3]
DOI 10.1016/j.jalz.2009.04.067
Co-authors Dimity Pond
2009 Pond CD, Magin PJ, Paterson NE, Horton GL, Goode SM, Swain J, et al., 'Diagnosing dementia in general practice: A team approach?', National Dementia Research Forum 2009, Sydney, NSW (2009) [E3]
Co-authors Graeme Horton, Parker Magin, Dimity Pond
2008 Pond CD, Mate KE, 'The detection and management of demetia in Australian general practice', Alzheimer's and Dementia, Chicago, IL (2008) [E3]
Co-authors Dimity Pond
2007 Czarny NA, Mate KE, Rodger JC, 'Acrosome stability in Dasyurid marsupials', Australian Mammal Society 53rd Scientific Meeting. Programme and Abstracts, Armidale (2007) [E3]
Co-authors John Rodger
2007 Pond CD, Bridges-Webb C, Beilby J, Brodaty H, Gunn J, Mate KE, Stocks N, 'The detection of dementia by Australian general practitioners', Australian and New Zealand Journal of Psychiatry, Melbourne (2007) [E3]
Co-authors Dimity Pond
2004 McCartney CA, Mate KE, 'Characterization of the marsupial zona pellucida.', BIOLOGY OF REPRODUCTION, Univ British Columbia, Vancouver, CANADA (2004)
Show 20 more conferences
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Grants and Funding

Summary

Number of grants 1
Total funding $26,694

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $26,694

The impact of changes in the anticholinergic load of medication regimens on the cognitive status and quality of life of people with dementia.$26,694

Funding body: The Mason Foundation

Funding body The Mason Foundation
Project Team Doctor Karen Mate, Doctor Karen Kerr, Professor Dimity Pond, Conjoint Professor Parker Magin
Scheme Medical and Scientific Research Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1400836
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y
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Research Supervision

Number of supervisions

Completed1
Current0

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2009 PhD Advances in Assisted Reproductive Techniques for Conservation of Australian Carnivorous Marsupials PhD (Biological Sciences), Faculty of Science, The University of Newcastle Co-Supervisor
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Dr Karen Mate

Position

Senior Lecturer
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Human Physiology

Contact Details

Email karen.mate@newcastle.edu.au
Phone (02) 4921 5983
Fax (02) 4921 7903

Office

Room LS350
Building Life Sciences
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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