Dr Jude Weidenhofer
Senior Lecturer
School of Biomedical Sciences and Pharmacy (Medical Biochemistry)
- Email:judith.weidenhofer@newcastle.edu.au
- Phone:(02) 4921 8706
Understanding cancer at a molecular level
Dr Jude Weidenhofer is taking her fascination for molecular biology to the next level, as she works to unravel the intricacies of extracellular signalling mechanisms to improve the accuracy of prostate and breast cancer diagnoses.
“I always enjoyed molecular biology in my undergrad degree. I didn’t know what I wanted to do but I knew that I wanted to help. Many young people who want to help patients go on to be doctors, but I wanted to do the kind of helping that helps them."
“That’s where biomedical research comes in.”
Grey areas in cancer medicine
Although survival rates for breast and prostate cancer have improved over the last 30 years, there are still ongoing problems with accurate diagnosis and therefore treatment. Both PSA tests (prostate specific antigen, a pathology test used to assess prostate cancer risk) and mammography screens can be problematic to interpret when it comes to patient prognosis.
“One of the biggest problems is that while we're quite good at treating some cancers, those treatments, and even just the prospect of that treatment, can really affect a person. There are a lot of false positives and false negatives, and so much patient anxiety associated with the diagnostic process."
“Some of these cancers grow so slowly that patients don’t actually need to undergo these drastic treatments in order for them to maintain their standard of living."
“So while researchers are always looking for better ways to treat, we’re also in the business of identifying people that don't actually need treatment.”
“Ideally we need to find a biomarker, or at least a combination of biomarkers, which will tell us which people need treatment, and which people don’t.”
Exosomes: a hot topic
In recent years, exosomes – vesicles secreted by the cell – have become a common theme of medical research.
“The big thinking in the cancer research world is that, by releasing exosomes, tumours can modify their surrounding environment and make it easier for cancerous cells to leave and trigger metastases.”
Exosomes are therefore an exciting potential cancer biomarker, and also give clues into the mechanisms behind cancer itself.
However, when it comes to physically researching them in the lab, exosomes are very tricky to work with.
“How do you define it? How do you know that’s what you’re looking at?
“It’s an exciting place but it’s also very unnerving because it’s all so new.”
There are ongoing discussions in the research community about what exactly constitutes an exosome and how scientists can verify that that is what they have isolated.
“The definition is actually very blurry. One of the suggestions has been that the tetraspanin CD9 is an exosome marker – and this may be, but I felt there had to be more to it than that!”
Tetraspanins and tumours
One of the reasons this suggestion had irked Jude is that she had been working on the group of tetraspanin molecules for many years before they were identified in this context.
“I’m pretty sure that your body doesn’t just put CD9 there so scientists can point at it and call it an exosome.”
Tetraspanins are located in the cell membrane and are responsible for assembling signalling complexes. They are known as scaffolding proteins, meaning they anchor lots of proteins together at one site of the cell membrane.
As part of her work funded by the Prostate Cancer Foundation Australia, in collaboration with Professor Leonie Ashman, Jude’s focus had been on tetraspanins as they have been proposed to have prognostic potential in prostate cancer biopsies.
“The more exosomes were looked at, the more relevant these tetraspanins become.”
And so Jude found her expertise coming into play in a whole new field of cancer research, thanks to funding through HMRI from a generous donation by the CFMEU Northern Mining and Energy Division.
“As prostate cancer progresses, there is less CD9 expressed on the surface of the cancer cells. But they are still packaging the protein into their exosomes which they release.
“We still don’t know why."
One question that Jude is keen to explore in her current research is the role that CD9 plays in affecting what message is sent by exomes to other parts of the body.
"You can't have a signalling body like an exosome which isn't selective - what would be the point?"
By genetically modifying the CD9 protein in a variety of prostate and breast cancer and normal cell lines, she is looking to identify just what it is this protein and the mysterious exosomes are up to.
Understanding cancer at a molecular level
Dr Jude Weidenhofer is focussed on understanding the role tetraspanin proteins improve the accuracy of prostate and breast cancer diagnoses.
Career Summary
Biography
I completed my PhD investigating the molecular and cellular role of the amygdala in the aetiology of schizophrenia in 2006 at the University of Newcastle. Following a post-doctoral position at the Children's Oncology Unit at the Children's Hospital at Westmead investigating the role of TPD52 in breast development and breast cancer I returned to the University of Newcastle in 2008. Whilst this position was as a teaching focused academic, I initiated my own research direction under the supervision of Prof. Leonie Ashman which resulted in successful funding from the Prostate Cancer Foundation of Australia. Since 2011 I have lead my own research group investigating the regulation of the expression of tetraspanin proteins in breast and prostate cancers as well as the role of CD151 in glomerular disease. More recently we have focussed on the role of tetraspanins in the function of extracellular vesicles and the subsequent function of these vesicles in cancer progression.
Research ExpertiseMy current research focus is on understanding the role of three tetraspanin proteins, CD151, CD9 and CD82 in breast and prostate cancers. These proteins show de-regulated expression in these cancers which is consistent with their proposed roles as tumour and metastasis enhancers (CD151) or suppressors (CD9 & CD82). Previously we have investigated the molecular mechanisms underlying their altered expression in cancer with a focus on the role of miRNA and the ubiquitin system. We hope that by improving our understanding of how the expression of these proteins is controlled we can gain valuable insight into how they can be used as both prognostic indicators as well as novel therapeutic targets, particularly for metastatic disease. Currently we are working towards an improved understanding of the make-up and function of extracellular vesicles released by cancer cells in the hope that we can identify biomarkers that can be assessed from blood samples.
Teaching Expertise
My current teaching focusses on human physiology and pathophysiology and analytical techniques for proteins. Previously I have taught genetics, bioinformatics and cancer cell biology, DNA, transcription, translation, protein synthesis and function and molecular biology. I have experience teaching B.Biomed Sci, B.Pharm, M. Pharmacy and B. Medicine and a number of Allied Health degrees.
Administrative Expertise
I have been on the organising committee for several symposiums and research seminar series as well as other research related events. I was the NSW State representative for the Australian Society for Biochemistry and Molecular Biology (ASBMB from 2012-2015). I am the deputy chair of the Institutional Biosafety Committee and also a part of other University and School based steering committees. In a teaching capacity I have co-ordinated several courses at the University of Newcastle.
Qualifications
- Doctor of Philosophy, University of Newcastle
Keywords
- Bioinformatics
- Biomarkers
- Breast Cancer
- Cancer Cell Biology
- Extracellular Vesicles
- Gene & Protein expression regulation
- Molecular Biology
- Prostate Cancer
- Protein biochemistry
- Tetraspanin proteins
Fields of Research
Code | Description | Percentage |
---|---|---|
321109 | Predictive and prognostic markers | 35 |
321101 | Cancer cell biology | 45 |
321107 | Liquid biopsies | 20 |
Professional Experience
UON Appointment
Title | Organisation / Department |
---|---|
Senior Lecturer | University of Newcastle School of Biomedical Sciences and Pharmacy Australia |
Academic appointment
Dates | Title | Organisation / Department |
---|---|---|
1/7/2006 - 1/5/2008 | Post-doctoral Researcher | The Children's Hospital at Westmead Molecular Oncogoly Group Australia |
Membership
Dates | Title | Organisation / Department |
---|---|---|
1/1/2006 - | Membership - Australian Society of Biochemistry and Molecular Biology | Australian Society of Biochemistry and Molecular Biology Australia |
1/1/2006 - | Membership - Australian Society of Medical Research | Australian Society of Medical Research Australia |
Professional appointment
Dates | Title | Organisation / Department |
---|---|---|
1/3/2012 - 31/12/2015 | NSW State Representative | Australian Society of Biochemistry and Molecular Biology Australia |
Invitations
Speaker
Year | Title / Rationale |
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2012 |
Role and regulation of tetraspanins CD151 and CD9 in breast and prostate cancers Organisation: Institut Andre Lwoff |
Publications
For publications that are currently unpublished or in-press, details are shown in italics.
Chapter (2 outputs)
Year | Citation | Altmetrics | Link |
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2020 | Weidenhofer J, 'Genetics', Fundamentals of Anatomy and Physiology For Nursing and Healthcare Students, John Wiley & Sons, UK (2020) | ||
2009 | Weidenhofer J, Byrne JA, 'Isolation of nucleic acids from hard tissues', Handbook of Nucleic Acid Purification, CRC PressI Llc, United States 427-448 (2009) |
Journal article (31 outputs)
Year | Citation | Altmetrics | Link | ||||||||
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2024 |
Paul CL, Verrills NM, Ackland S, Scott R, Goode S, Thomas A, et al., 'The impact of a regionally based translational cancer research collaborative in Australia using the FAIT methodology.', BMC Health Serv Res, 24 320 (2024) [C1]
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2023 |
Barnett MM, Reay WR, Geaghan MP, Kiltschewskij DJ, Green MJ, Weidenhofer J, et al., 'miRNA cargo in circulating vesicles from neurons is altered in individuals with schizophrenia and associated with severe disease.', Sci Adv, 9 eadi4386 (2023) [C1]
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2023 |
Dobhal G, Cottam S, Jankowski H, Weidenhofer J, Goreham RV, 'Isolation and substrate dependence on extracellular vesicle characterisation using atomic force microscopy', Nano Express, 4 035003-035003 (2023) [C1]
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2022 |
Tiburcius S, Krishnan K, Patel V, Netherton J, Sathish C, Weidenhofer J, et al., 'Triple Surfactant Assisted Synthesis of Novel Core-Shell Mesoporous Silica Nanoparticles with High Surface Area for Drug Delivery for Prostate Cancer', BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 95 331-340 (2022) [C1]
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2022 |
Tiburcius S, Krishnan K, Jose L, Patel V, Ghosh A, Sathish C, et al., 'Egg-yolk core-shell mesoporous silica nanoparticles for high doxorubicin loading and delivery to prostate cancer cells', NANOSCALE, 14 6830-6845 (2022) [C1]
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2022 |
Mate K, Weidenhofer J, 'Considerations and strategies for effective online assessment with a focus on the biomedical sciences', FASEB BioAdvances, 4 9-21 (2022) [C1] The COVID-19 pandemic in 2020 caused many universities to rapidly transition into online learning and assessment. For many this created a marked shift in design of assessments in ... [more] The COVID-19 pandemic in 2020 caused many universities to rapidly transition into online learning and assessment. For many this created a marked shift in design of assessments in an attempt to counteract the lack of invigilation of examinations conducted online. While disruptive for both staff and students, this sudden change provided a much needed reconsideration of the purpose of assessment. This review considers the implications of transitioning to online assessment providing practical strategies for achieving authentic assessment of students online, while ensuring standards and accountability against professional accrediting body requirements. The case study presented demonstrates that an online multiple choice assessment provides similar rigor in assessment to invigilated examination of the same concepts in human physiology. Online assessment has the added benefit of enabling rapid and specific feedback to large cohorts of students on their personal performance, allowing students to target their weaker areas for remediation. This has implications for improving both pedagogy and efficiency in assessment of large cohorts where the default is often to assess basic recall knowledge in a multiple choice assessment. This review examines the key elements for implementation of online assessments including consideration of the role of assessment in teaching and learning, the rationale for online delivery, accessibility of the assessment from both a technical and equity perspective, academic integrity as well as the authenticity and structure of the assessment.
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2022 |
Onyiba CI, Scarlett CJ, Weidenhofer J, 'The Mechanistic Roles of Sirtuins in Breast and Prostate Cancer.', Cancers, 14 5118 (2022) [C1]
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2020 |
Turner A, Bond DR, Vuong QV, Chalmers A, Beckett EL, Weidenhofer J, Scarlett CJ, 'Elaeocarpus reticulatus fruit extracts reduce viability and induce apoptosis in pancreatic cancer cells in vitro', Molecular Biology Reports, 47 2073-2084 (2020) [C1]
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2020 |
Bond DR, Kahl R, Brzozowski JS, Jankowski H, Naudin C, Pariyar M, et al., 'Tetraspanin CD9 is regulated by MiR-518f-5p and functions in breast cell migration and in vivo tumor growth', Cancers, 12 (2020) [C1]
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2019 |
Predebon MJ, Bond DR, Brzozowski J, Jankowski H, Deane F, Tarleton M, et al., 'The bispidinone derivative 3,7-Bis-[2-(S)-amino-3-(1H-indol-3-yl)-propionyl]-1,5-diphenyl-3,7-diazabicyclo[3.3.1]nonan-9-one dihydrochloride induces an apoptosis-mediated cytotoxic effect on pancreatic cancer cells in vitro', Molecules, 24 (2019) [C1]
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2018 |
Brzozowski JS, Jankowski H, Bond DR, McCague SB, Munro BR, Predebon MJ, et al., 'Lipidomic profiling of extracellular vesicles derived from prostate and prostate cancer cell lines.', Lipids Health Dis, 17 211 (2018) [C1]
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2018 |
Brzozowski JS, Bond DR, Jankowski H, Goldie BJ, Burchell R, Naudin C, et al., 'Extracellular vesicles with altered tetraspanin CD9 and CD151 levels confer increased prostate cell motility and invasion', Scientific Reports, 8 1-13 (2018) [C1]
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2018 |
Bond DR, Naudin C, Carroll AP, Goldie BJ, Brzozowski JS, Jankowski HM, et al., 'miR-518f-5p decreases tetraspanin CD9 protein levels and differentially affects non-tumourigenic prostate and prostate cancer cell migration and adhesion', ONCOTARGET, 9 1980-1991 (2018) [C1]
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2018 |
Goldsmith CD, Bond D, Jankowski H, Weidenhofer JC, Stathopoulos C, Roach PD, Scarlett CJ, 'The Olive Biophenols Oleuropein and Hydroxytyrosol Selectively Reduce Proliferation, Influence the Cell Cycle, and Induce Apoptosis in Pancreatic Cancer Cells', International Journal of Molecular Sciences, 19 (2018) [C1]
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2017 |
Naudin C, Smith B, Bond DR, Dun MD, Scott RJ, Ashman LK, et al., 'Characterization of the early molecular changes in the glomeruli of Cd151 -/- mice highlights induction of mindin and MMP-10.', Scientific Reports, 7 15987-15987 (2017) [C1]
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2017 |
Goldie BJ, Fitzsimmons C, Weidenhofer J, Atkins JR, Wang DO, Cairns MJ, 'miRNA Enriched in Human Neuroblast Nuclei Bind the MAZ Transcription Factor and Their Precursors Contain the MAZ Consensus Motif', FRONTIERS IN MOLECULAR NEUROSCIENCE, 10 (2017) [C1]
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2016 |
Weidenhofer JC, Colvin EK, Bond DR, Scarlett CJ, 'Animal models of pancreatic cancer and their application in clinical research', Gastrointestinal Cancer : Targets and Therapy, 2016 31-39 (2016) [C1]
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2014 |
Vuong QV, Sadeqzadeh E, Hirun S, Goldsmith CD, Zammitt N, Bowyer MB, et al., 'Phenolic Compounds, Antioxidant and Anti-Cancer Properties of the Australian Maroon Bush Scaevola spinescens (Goodeniaceae)', Journal of Bioanalysis & Biomedicine, S12 (2014) [C1]
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2014 |
Roselli S, Kahl RGS, Copeland BT, Naylor MJ, Weidenhofer J, Muller WJ, Ashman LK, 'Deletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model', BMC Cancer, 14 (2014) [C1] Background: Tetraspanins are transmembrane proteins that serve as scaffolds for multiprotein complexes containing, for example, integrins, growth factor receptors and matrix metal... [more] Background: Tetraspanins are transmembrane proteins that serve as scaffolds for multiprotein complexes containing, for example, integrins, growth factor receptors and matrix metalloproteases, and modify their functions in cell adhesion, migration and transmembrane signaling. CD151 is part of the tetraspanin family and it forms tight complexes with ß1 and ß4 integrins, both of which have been shown to be required for tumorigenesis and/or metastasis in transgenic mouse models of breast cancer. High levels of the tetraspanin CD151 have been linked to poor patient outcome in several human cancers including breast cancer. In addition, CD151 has been implicated as a promoter of tumor angiogenesis and metastasis in various model systems.Methods: Here we investigated the effect of Cd151 deletion on mammary tumorigenesis by crossing Cd151-deficient mice with a spontaneously metastasising transgenic model of breast cancer induced by the polyoma middle T antigen (PyMT) driven by the murine mammary tumor virus promoter (MMTV).Results: Cd151 deletion did not affect the normal development and differentiation of the mammary gland. While there was a trend towards delayed tumor onset in Cd151 -/- PyMT mice compared to Cd151 +/+ PyMT littermate controls, this result was only approaching significance (Log-rank test P-value =0.0536). Interestingly, Cd151 deletion resulted in significantly reduced numbers and size of primary tumors but did not appear to affect the number or size of metastases in the MMTV/PyMT mice. Intriguingly, no differences in the expression of markers of cell proliferation, apoptosis and blood vessel density was observed in the primary tumors.Conclusion: The findings from this study provide additional evidence that CD151 acts to enhance tumor formation initiated by a range of oncogenes and strongly support its relevance as a potential therapeutic target to delay breast cancer progression. © 2014 Roselli et al.; licensee BioMed Central Ltd.
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2014 |
Bond DB, Brzozowski J, Skelding KA, Roselli SR, Weidenhofer J, 'Use of tetraspanins CD151 and CD9 as biomarkers for breast cancer', Breast Cancer Management, 3 123-126 (2014) [C3]
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2014 |
Mate K, Riveros C, Weidenhofer J, Goldie B, Scott J, Moscato P, et al., 'Strategies for Enhancing Communication between Students, Academics and Researchers participating in Large-Scale Undergraduate Research Projects', International Journal of Innovation in Science and Mathematics Education, 22 14-29 (2014) [C1]
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2013 |
Mate K, Sim A, Weidenhofer J, Milward L, Scott J, 'Investigation of the human disease osteogenesis imperfecta: A research-based introduction to concepts and skills in biomolecular analysis', Biochemistry & Molecular Biology Education, 41 103-109 (2013) [C1]
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2012 |
Tynan R, Weidenhofer JC, Hinwood M, Cairns MJ, Day TA, Walker FR, 'A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia', Brain Behavior and Immunity, 26 469-479 (2012) [C1]
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2009 |
Weidenhofer JC, Ashman LK, 'CD151 (CD151 molecule (Raph blood group))', Atlas of Genetics and Cytogenetics in Oncology and Haematology, - - (2009) [C1]
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2009 |
Weidenhofer JC, Scott R, Tooney PA, 'Investigation of the expression of genes affecting cytomatrix active zone function in the amygdala in schizophrenia: Effects of antipsychotic drugs', Journal of Psychiatric Research, 43 282-290 (2009) [C1]
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2006 |
Weidenhofer JC, Bowden NA, Scott R, Tooney PA, 'Altered gene expression in the amygdala in schizophrenia: Up-regulation of genes located in the cytomatrix active zone', Molecular and Cellular Neuroscience, 31 243-250 (2006) [C1]
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2006 |
Weidenhofer JC, Yip JR, Zavitsanou K, Huang XF, Chahl LA, Tooney PA, 'Immunohistochemical localisation of the NK1 receptor in the human amygdala: Preliminary investigation in schizophrenia', Progress in Neuro-Psychopharmacology and Biological Psychiatry, 30 1313-1321 (2006) [C1]
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2006 |
Bowden NA, Weidenhofer JC, Scott R, Schall U, Todd J, Michie PT, Tooney PA, 'Preliminary investigation of gene expression profiles in peripheral blood lymphocytes in schizophrenia', Schizophrenia Research, 82 175-183 (2006) [C1]
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Show 28 more journal articles |
Conference (33 outputs)
Year | Citation | Altmetrics | Link | |||||
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2023 |
Barnett M, Reay W, Geaghan M, Kiltschewskij D, Green M, Weidenhofer J, et al., 'CIRCULATING VESICULAR MIRNA DERIVED FROM NEURONS ARE ASSOCIATED WITH COGNITIVE IMPAIRMENT AND TREATMENT RESISTANCE IN INDIVIDUALS WITH SCHIZOPHRENIA', EUROPEAN NEUROPSYCHOPHARMACOLOGY, CANADA, Montreal (2023)
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2021 |
Mate K, Weidenhofer J, 'ARE ONLINE EXAMINATIONS A VIABLE
ALTERNATIVE TO PAPER-BASED
EXAMINATIONS FOR ASSESSMENT OF
HUMAN PHYSIOLOGY?', Sydney (2021)
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2020 |
Jankowski H, Munro B, Brzozowski J, Scarlett C, Skelding K, Weidenhofer J, 'Extracellular vesicles identify novel prostate cancer biomarkers', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2020)
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2019 |
Mate K, Weidenhofer J, Smith J, Yates Z, Evans S, 'The invisible academics', Proceedings of The Australian Conference on Science and Mathematics Education, Sydney (2019) [E1]
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2015 |
Jankowski H, Goldie B, Brzozowski J, Bond D, Scarlett C, Skelding KA, Weidenhofer J, 'Differences in extracellular vesicle nucleic acid content show promise as prostate cancer biomarkers', Boston, MA (2015) [O1]
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2015 |
Naudin C, Weidenhofer J, Roselli S, Keely S, 'Induction of Mindin is Associated with Pathological Changes in the Kidney of Cd151(-/-) Mice', FASEB JOURNAL (2015) [E3]
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2015 |
Brzozowski J, Coldie B, Jankowski H, Bond D, Scarlett C, Dun M, et al., 'THE EFFECTS OF ALTERED CD9 AND CD151 EXPRESSION ON PROSTATE EXOSOMES', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2015) [E3]
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2015 |
Jankowski H, Goldie B, Brzozowski J, Bond D, Scarlett C, Skelding K, Weidenhofer J, 'PROSTATE CANCER BIOMARKERS: ARE EXTRACELLULAR VESICLES THE SOLUTION?', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2015) [E3]
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2015 |
Bond D, Turner A, Richmond R, Sadeqzadeh E, Vuong Q, Bhuyan D, et al., 'THE SEARCH FOR NOVEL TREATMENT AGENTS FOR PANCREATIC CANCER: TALES FROM THE LAND AND SEA', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2015) [E3]
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2015 |
Predebon M, Bond D, Brzozowski J, Jankowski H, Deane F, Tarleton M, et al., 'A BISPIDINONE ANALOGUE INDUCES AN APOPTOSIS-MEDIATED CYTOTOXIC EFFECT ON PANCREATIC CANCER CELLS IN VITRO', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2015) [E3]
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2014 |
Bond DR, Passfield C, Cairns M, Ashman LK, Weidenhofer J, 'Posttranscriptional regulation of tetraspanins CD151 & CD9 in breast & prostate cancers', CANCER RESEARCH, San Diego, CA (2014) [E3]
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2014 |
Sadeqzadeh E, Vuong QV, Goldsmith CD, Nguyen VT, Bhuyan DJ, Trung TD, et al., 'A NATURAL PRODUCT DRUG DISCOVERY PIPELINE FOR NOVEL PANCREATIC CANCER THERAPIES: A NEW CANCER RESEARCH HUB FOR THE HUNTER REGION OF NSW', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
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2013 |
Weidenhofer J, Bond D, Copeland B, Ashman L, 'Tetraspanin protein turnover rates vary in prostate cancer cell lines', BJU INTERNATIONAL (2013) [E3]
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2013 |
Bond D, Cairns M, Ashman L, Weidenhofer J, 'Post-transcriptional regulation of CD151 & CD9 by miRNAs in prostate cancer', BJU INTERNATIONAL (2013) [E3]
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2012 |
Bond DR, Cairns MJ, Ashman LK, Weidenhofer JC, 'Investigating micro-RNA regulation of tetraspanins CD151 and CD9 in prostate cancer', Febs Journal, Seville, Spain (2012) [E3]
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2011 |
Naudin C, Weidenhofer JC, Scott R, Ashman LK, Roselli SM, 'Induction of mindin expression is associated with glomerular basement membrane damage in Cd151(-/-) mice', Nephrology, Adelaide, SA (2011) [E3]
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2006 |
Weidenhofer JC, Bowden NA, Scott R, Tooney PA, 'Dysfunction of genes regulating membrane exocytosis in schizophrenia (Poster presentation)', Australian and New Zealand Journal of Psychiatry (Vol 40, noS2), Fremantle, Western Australia (2006) [E3]
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2005 |
Bowden NA, Weidenhofer JC, Scott R, Schall UA, Todd J, Michie PT, Tooney PA, 'Classification of schizophrenia using differential gene expression in peripheral blood lymphocytes', Human Genetics Society of Australasia, Newcastle (2005) [E3]
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2004 |
Bowden NA, Weidenhofer JC, Scott R, Todd J, Case V, Schall UA, Tooney PA, 'Altered Expression of Brain Related Genes in Lymphocytes in Schizophrenia', American Journal of Medical Genetics, Ireland (2004) [E3]
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2004 |
Weidenhofer JC, Bowden NA, Scott R, Tooney PA, 'Gene Profiling in the Amygdala in Schizophrenia', American Journal of Medical Genetics, Ireland (2004) [E3]
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2004 |
Bowden NA, Weidenhofer JC, Scott R, Todd J, Case V, Schall UA, Tooney PA, 'Differental Gene Expression in Peripheral Blood Lymphocytes in Schizophrenia', Proceedings of the Australian Neuroscience Society, Melbourne (2004) [E3]
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2004 |
Weidenhofer JC, Bowden NA, Scott R, Tooney PA, 'Altered Gene Expression Profiles in the Amygdala in Schizophrenia', Proceedings of the Australian Neuroscience Society, Melbourne (2004) [E3]
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2004 |
Bowden NA, Weidenhofer JC, Scott R, Todd J, Case V, Schall UA, Tooney PA, 'Distinct Gene Expression Profiles due to Age in Schizophrenia', Proceedings of the Australian Neuroscience Society, Melbourne (2004) [E3]
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Show 30 more conferences |
Grants and Funding
Summary
Number of grants | 19 |
---|---|
Total funding | $1,546,095 |
Click on a grant title below to expand the full details for that specific grant.
20231 grants / $10,000
Improving Outcomes of Cancer Patients$10,000
Funding body: Crestani Family Foundation
Funding body | Crestani Family Foundation |
---|---|
Project Team | Doctor Jude Weidenhofer, Doctor Michael Bourke, Professor Christopher Scarlett |
Scheme | Scholarships in Radiotherapy |
Role | Lead |
Funding Start | 2023 |
Funding Finish | 2024 |
GNo | G2301402 |
Type Of Funding | C3300 – Aust Philanthropy |
Category | 3300 |
UON | Y |
20221 grants / $65,000
Quality Advancement for Biobanking – Fostering Collaboration and Maximizing Patient Benefit$65,000
Funding body: Mark Hughes Foundation
Funding body | Mark Hughes Foundation |
---|---|
Project Team | Professor Rodney Scott, Kim Alexander, Ms Cassandra Griffin, Professor Christine Paul, Mr Ricardo Vilain, Doctor Jude Weidenhofer |
Scheme | Research Funding |
Role | Investigator |
Funding Start | 2022 |
Funding Finish | 2022 |
GNo | G2200887 |
Type Of Funding | Scheme excluded from IGS |
Category | EXCL |
UON | Y |
20191 grants / $15,000
A new diagnostic test for prostate cancer$15,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Mr Brayden March, Doctor Sam Faulkner, Doctor Jude Weidenhofer, Doctor Peter Pockney |
Scheme | Research Grant |
Role | Investigator |
Funding Start | 2019 |
Funding Finish | 2020 |
GNo | G1901603 |
Type Of Funding | C3300 – Aust Philanthropy |
Category | 3300 |
UON | Y |
20162 grants / $28,750
Circulating exosomes in pancreatic cancer as a source of novel diagnostic biomarkers$23,750
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Christopher Scarlett, Doctor Jude Weidenhofer, Associate Professor Kelly Kiejda |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2016 |
Funding Finish | 2016 |
GNo | G1601070 |
Type Of Funding | Grant - Aust Non Government |
Category | 3AFG |
UON | Y |
Equipment Grant: Developing Synthetic Exosomes to Target and Deliver Anti-Cancer Agents to Prostate Cancer$5,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Mr Joshua Brzozowski, Doctor Jude Weidenhofer, Associate Professor Kathryn Skelding, Professor Christopher Scarlett |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2016 |
Funding Finish | 2016 |
GNo | G1601042 |
Type Of Funding | Grant - Aust Non Government |
Category | 3AFG |
UON | Y |
20145 grants / $603,199
Tetraspanin CD9; more than just an exosome marker - A novel biomarker to target for prostate cancer$400,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Doctor Jude Weidenhofer, Associate Professor Kathryn Skelding, Professor Matt Dun, Ms Belinda Goldie, Doctor Danielle Bond |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2014 |
Funding Finish | 2017 |
GNo | G1400921 |
Type Of Funding | C3300 – Aust Philanthropy |
Category | 3300 |
UON | Y |
Visualisation of microparticles for development of biomarkers and targeted drug delivery mechanisms$125,199
Funding body: Cancer Institute NSW
Funding body | Cancer Institute NSW |
---|---|
Project Team | Professor Christopher Scarlett, Associate Professor Kathryn Skelding, Doctor Jude Weidenhofer, Professor Matt Dun, Associate Professor Kelly Kiejda, Professor Adam McCluskey, Doctor Elham Sadeqzadeh, Professor Hubert Hondermarck, Doctor Rick Thorne, Professor Rodney Scott |
Scheme | Research Equipment Grant |
Role | Investigator |
Funding Start | 2014 |
Funding Finish | 2014 |
GNo | G1400627 |
Type Of Funding | Other Public Sector - State |
Category | 2OPS |
UON | Y |
Developing Synthetic Exosomes to Target and Deliver Anti-Cancer Agents to Prostate Cancer Cells$37,500
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Mr Joshua Brzozowski, Doctor Jude Weidenhofer, Associate Professor Kathryn Skelding |
Scheme | Postgraduate Research Scholarship |
Role | Lead |
Funding Start | 2014 |
Funding Finish | 2016 |
GNo | G1401405 |
Type Of Funding | Grant - Aust Non Government |
Category | 3AFG |
UON | Y |
Identification and evaluation of anti-pancreatic cancer activity of cytotoxic compounds extracted from Australian sea sponges: a pilot study$20,500
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Christopher Scarlett, Doctor Quan Vuong, Doctor Jude Weidenhofer, Doctor Rick Thorne, Professor Michael Bowyer, Associate Professor Troy Gaston |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2014 |
Funding Finish | 2015 |
GNo | G1401452 |
Type Of Funding | Grant - Aust Non Government |
Category | 3AFG |
UON | Y |
A new frontier in breast cancer: Can small molecules in the blood predict outcome?$20,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Associate Professor Kelly Kiejda, Doctor Jude Weidenhofer, Professor Rodney Scott |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2014 |
Funding Finish | 2014 |
GNo | G1401454 |
Type Of Funding | Grant - Aust Non Government |
Category | 3AFG |
UON | Y |
20131 grants / $24,596
Ultra-Low Temperature Cryogenic Freezer$24,596
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Doctor Jude Weidenhofer, Doctor Rick Thorne, Associate Professor Kathryn Skelding, Associate Professor Nikki Verrills, Professor Pradeep Tanwar, Associate Professor Phillip Dickson, Professor Murray Cairns, Professor Hubert Hondermarck, Professor Xu Dong Zhang, Associate Professor Estelle Sontag, Doctor Chen Chen Jiang, Prof LIZ Milward, Doctor Jean-Marie Sontag, Associate Professor Paul Tooney, Doctor Severine Roselli Dayas, Professor Matt Dun, Professor Chris Dayas, Doctor Lin Kooi Ong, Professor Dirk Van Helden, Mr Ben Copeland, Doctor Gabrielle Briggs, Emeritus Professor Leonie Ashman, Emeritus Professor John Rostas |
Scheme | Equipment Grant |
Role | Lead |
Funding Start | 2013 |
Funding Finish | 2013 |
GNo | G1201189 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
20124 grants / $355,550
The Hunter Cancer Biobank (HCB): Maximising community value through validation, annotation and distribution throughout NSW$292,300
Funding body: Cancer Institute NSW
Funding body | Cancer Institute NSW |
---|---|
Project Team | Emeritus Professor John Forbes, Conjoint Professor Stephen Ackland, Professor Rodney Scott, Conjoint Associate Professor Barbara Young, Professor Hubert Hondermarck, Emeritus Professor Leonie Ashman, Professor Xu Dong Zhang, Associate Professor Kelly Kiejda, Associate Professor Nikki Verrills, Doctor Jennette Sakoff, Ms Janine Lombard, Doctor Jude Weidenhofer, Professor Pradeep Tanwar |
Scheme | Research Infrastructure Grants |
Role | Investigator |
Funding Start | 2012 |
Funding Finish | 2015 |
GNo | G1200798 |
Type Of Funding | Other Public Sector - State |
Category | 2OPS |
UON | Y |
Microscopic illumination system for advanced fluorescent protein technology$34,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Doctor Rick Thorne, Professor Xu Dong Zhang, Professor Murray Cairns, Associate Professor Nikki Verrills, Doctor Charles De Bock, Doctor Jude Weidenhofer, Doctor Severine Roselli Dayas, Associate Professor Kathryn Skelding, Emeritus Professor Leonie Ashman, Professor Hubert Hondermarck |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2012 |
Funding Finish | 2012 |
GNo | G1100983 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
Does Ubiquitination control the altered expression of tetraspanin proteins in Breast Cancer?$25,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Doctor Jude Weidenhofer, Emeritus Professor Leonie Ashman, Professor Hubert Hondermarck |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2012 |
Funding Finish | 2012 |
GNo | G1200169 |
Type Of Funding | Contract - Aust Non Government |
Category | 3AFC |
UON | Y |
PULSE - Education Prize$4,250
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Doctor Jude Weidenhofer |
Scheme | PULSE Education Prize |
Role | Lead |
Funding Start | 2012 |
Funding Finish | 2012 |
GNo | G1200157 |
Type Of Funding | Scheme excluded from IGS |
Category | EXCL |
UON | Y |
20113 grants / $410,000
Identifying the mechanisms underlying altered expression and mode of action of tetraspanins CD151 and CD9 in metastasis: progression to targeted treatment for prostate cancer$375,000
Funding body: Prostate Cancer Foundation of Australia
Funding body | Prostate Cancer Foundation of Australia |
---|---|
Project Team | Emeritus Professor Leonie Ashman, Doctor Jude Weidenhofer |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2011 |
Funding Finish | 2013 |
GNo | G1000863 |
Type Of Funding | Aust Competitive - Non Commonwealth |
Category | 1NS |
UON | Y |
Investigation of the function of CD151 in the glomerular filtration barrier and identification of genetic modifiers of glomerular diseases$25,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Doctor Severine Roselli Dayas, Doctor Jude Weidenhofer, Emeritus Professor Leonie Ashman |
Scheme | Near Miss Grant |
Role | Investigator |
Funding Start | 2011 |
Funding Finish | 2011 |
GNo | G1001053 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
IMPLEN NanoPhotometer pearl$10,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Murray Cairns, Associate Professor Paul Tooney, Professor Alan Brichta, Emeritus Professor John Rostas, Emeritus Professor Patricia Michie, Conjoint Professor Keith Jones, Prof ULLI Schall, Associate Professor Phillip Dickson, Professor Rohan Walker, Doctor Rick Thorne, Professor Chris Dayas, Associate Professor Nikki Verrills, Doctor Janet Bristow, Doctor Severine Roselli Dayas, Associate Professor Kathryn Skelding, Doctor Jude Weidenhofer, Prof LIZ Milward, Doctor Charles De Bock, Doctor Julie Merriman-Jones, Doctor Jing Qin Wu, Doctor Bing Liu, Doctor Dan Johnstone, Ms Belinda Goldie, Doctor Natalie Beveridge |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2011 |
Funding Finish | 2011 |
GNo | G1100030 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
20101 grants / $34,000
ABI 7500 Real Time PCR System $34,000
Funding body: NHMRC (National Health & Medical Research Council)
Research Supervision
Number of supervisions
Current Supervision
Commenced | Level of Study | Research Title | Program | Supervisor Type |
---|---|---|---|---|
2022 | PhD | Quantitation of Sirtuin Proteins, Messenger RNAs, and their Regulatory Non-coding RNAs in Extracellular Vesicles Derived from Breast and Prostate Cancer | PhD (Medical Biochemistry), College of Health, Medicine and Wellbeing, The University of Newcastle | Principal Supervisor |
2018 | PhD | Nucleic Acid Biomarkers of Neurological Disorders from Brain-Derived Serum Extracellular Vesicles | PhD (Medical Genetics), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
Past Supervision
Year | Level of Study | Research Title | Program | Supervisor Type |
---|---|---|---|---|
2019 | PhD | Identification of Biomarkers and Novel Targets for Prostate Cancer from Extracellular Vesicles | PhD (Medical Biochemistry), College of Health, Medicine and Wellbeing, The University of Newcastle | Principal Supervisor |
2018 | PhD | Characterisation of the Membrane Composition and Function of Extracellular Vesicles from Prostate Cells | PhD (Medical Biochemistry), College of Health, Medicine and Wellbeing, The University of Newcastle | Principal Supervisor |
2015 | PhD | The Tetraspanin CD151's Role in the Kidney and Mapping of Genetic Modifiers of Glomerular Diseases | PhD (Medical Biochemistry), College of Health, Medicine and Wellbeing, The University of Newcastle | Principal Supervisor |
2015 | PhD | Post-Transcriptional Regulation of Tetraspanins CD151 and CD9 by Micro-RNAs in Prostate and Breast Cancers | PhD (Medical Biochemistry), College of Health, Medicine and Wellbeing, The University of Newcastle | Principal Supervisor |
2013 | PhD | Tetraspanins as Biomarkers and Causative Proteins in Prostate Cancer | PhD (Medical Biochemistry), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
Dr Jude Weidenhofer
Position
Senior Lecturer
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing
Focus area
Medical Biochemistry
Contact Details
judith.weidenhofer@newcastle.edu.au | |
Phone | (02) 4921 8706 |
Fax | (02) 43494538 |
Office
Room | HO147 |
---|---|
Location | Ourimbah 10 Chittaway Road Ourimbah, NSW 2258 Australia |