Profile Image

Professor John Attia

Academic Director

School of Medicine and Public Health

Supporting Research Excellence in the Hunter

Although he’s not quite where he imagined he’d be, Professor John Attia admits that there’s never a boring day as Director of the Clinical Research Design, IT and Statistical Support (CReDITSS) Unit.

Professor John Attia

“When I first came across epidemiology, I thought it was probably just going to help me with my own research.

“A major turning point was when I realised I really enjoyed the methods part of it. It’s a really creative process.

“When we sit down with a researcher, we’ll listen to what their question is, what their budget is, what data they have – and we have to think about what's the best way to answer this question within the confines of what is feasible.”

It's not exactly brain surgery ...

As well as working alongside researchers in a consultation capacity, John is not only a researcher himself, he is also a medical doctor. He works at the John Hunter Hospital for three months out of the year as a general physician.

“I always wanted to be a doctor when I was growing up - I really wanted to become a brain surgeon, and I wanted to run a lab too."

“So I went into medical school at the University of Toronto, where they had a joint MD/ PhD program."

“For my first two years at medical school, we studied all the basic sciences, and then I went off and did my PhD in neurobiology."

“After that I did my clinical study years and then went on and did clinical internship."

“Then when I finally got the chance to do a rotation in neurosurgery - I hated it.”

The research environment had also failed to win John over – or so he thought.

John’s PhD project had been entirely lab based, wherein he spent his time searching for an elusive protein thought to be involved with Multiple Sclerosis. Despite trialing a number of scientific methods in his search for the protein, John’s search was fruitless.

“I was working for five years, got nowhere, found nothing and I thought - I'm never going back to research again.”

Evidence-based medicine

Little did John know, there were big changes on the horizon of traditional clinical practice, and those changes incorporated the very field he thought he was finished with.

“Just at the time I was graduating medical school, the whole field in genetic epidemiology was opening up.

“When I did my internship and residency at McMaster University, where the evidence based medicine movement began, I found that I really enjoyed epidemiology and that whole way of approaching and interpreting evidence.

“In hindsight, I recognise now how things work out – the fact that I couldn’t find that protein I was looking for in my PhD, forced me to try all of these different methods.

“That exposure to molecular biology was just what I needed to be able to understand genetic epidemiology.”

“So I brought my basic science and my MD together.”

Around that time, UON was looking to establish epidemiology courses with an emphasis on molecular epidemiology. They had sent out recruitment emails for a Senior Lectureship position via McMaster.

“I applied for that and I got it and things couldn’t have worked out better.”

Vaccination and atherosclerosis

“In 2003, I read a paper in Nature Medicine that really piqued my interest.

“It was looking at the pneumococcal vaccine in mice and how it protected them against the mouse equivalent of atherosclerosis.”

“I looked at it and thought – this is amazing!”

The researchers had found that the “bad cholesterol” which characterises atherosclerosis has molecular similarities to a lipid in the cell wall of the pneumococcal bacteria.

In response to the vaccine, the immune system produces specific antibodies which recognise not only the bacteria but also the fatty deposits in the arteries. Both are marked for degradation by immune cells. Theoretically therefore, the body is protected from infection, and the risk for heart attacks and strokes is reduced at the same time.

“But I looked in the literature and there was nothing on humans.”

Atherosclerosis occurs when fat builds up on the interior walls of blood vessels, causing their diameter to decrease. This increases the risk of heart attack and stroke.

Since this initial publication in Nature, there have been a number of observational studies which find this same connection between the vaccine and heart attack and stroke risk in the human population. But, as any epidemiologist will tell you, correlation does not equal causation.

“I decided that every two years I would put in a grant to the NHMRC, trying to get the money to look at this in the context of a randomised control trial.

“It’s the only way to answer our question– it could be that people heavily invested in their own well-being would want the vaccine and therefore experience these effects, and this would bias the results.”

In 2013, after ten years of trying, John finally got the research grant he had been hoping for.

“We’re now working on a full scale randomised control trial with 6000 patients across five Australian states and territories.

“If we can prove this benefit is real, then one vaccine will work as well as a lifetime of statins or beta blockers - it's the same magnitude of effect in terms of protection.

“Those things cost thousands of dollars plus trying to remember to take your pill every day."

"This is the biggest thing I’ve ever worked on in my career."

Supporting Research Excellence in the Hunter

John's research expertise includes clinical, molecular, and genetic epidemiology methods

Read more

Career Summary

Biography

Professor John Attia obtained a BSc in Physiology (Faculty scholar at McGill University) and then won a 5 year MRC scholarship to complete his MD/PhD in Molecular Genetics (University of Toronto). He trained at McMaster University (Canada) in general internal medicine and obtained his fellowship with the Royal College of Physicians of Canada and the Royal Australasian College of Physicians. During this time he was awarded the Outstanding Housestaff award, the J.T. Walsh award for outstanding Internal Medicine resident, and Best Teacher in Internal Medicine. During his residency, he also completed his MSc in Epidemiology (McMaster University). He has been listed on the NHMRC register of Evidence-Based Medicine experts and has provided epidemiological expertise to the Therapeutic Goods Administration. In 2012, he won the senior research excellence award from both the Faculty of Health (University of Newcastle) and the Hunter Medical Research Institute. 

Between 1999 and 2016, he has collaborated in obtaining $20 million in grant income and published over 400 manuscripts (with another 5 submitted); these have garnered over 7000 citations, leading to an h-index of 42 (Scopus data April 2016). He has also submitted 7 government reports, and 7 book chapters. He has been supervisor or co-supervisor to 26 PhD students (16 graduated and 10 current) and 6 Master’s students (all graduated). He is currently academic director of general medicine at John Hunter Hospital responsible for the foundation and running of the advanced training program for general physicians, one of the only fully supported such programs in the state. He is also co-director of the Clinical Research Design, IT, and Statistical Support (CReDITSS) Unit, a unit that provides methodological and analysis advice to clinical researchers.

Research Expertise
John's research expertise includes clinical, molecular, and genetic epidemiology methods. Clinical epidemiology covers such topics as population- and hospital-based observational studies (cohort, case-control, crossover) and controlled clinical trials as well as studies of diagnostic tests, meta-analyses, and health services research. Molecular epidemiology focuses mainly on evaluation of biomarkers. Genetic epidemiology covers design and analysis of genome-wide association studies of various complex diseases, particularly macular degeneration and stroke. 

Qualifications

  • PhD, University of Toronto
  • Bachelor of Science, McGill University - Canada
  • Master of Science, McMaster University - Canada
  • Doctor of Medicine, University of Toronto

Keywords

  • clinical epidemiology
  • genetic epidemiology
  • public health

Languages

  • French (Fluent)

Fields of Research

Code Description Percentage
010499 Statistics not elsewhere classified 15
110399 Clinical Sciences not elsewhere classified 45
111799 Public Health and Health Services not elsewhere classified 40

Professional Experience

UON Appointment

Title Organisation / Department
Professor University of Newcastle
School of Medicine and Public Health
Australia

Academic appointment

Dates Title Organisation / Department
1/01/2006 -  Epidemiology Expert to the Complementary Medicines Advisory Committee Therapeutic goods administration
Australia
1/01/2003 -  Evidence-based medicine expert to assist groups in developing EBM guidelines NHMRC (National Health & Medical Research Council)

Membership

Dates Title Organisation / Department
Member - Royal Australasian College of Physicians The Royal Australasian College of Physicians
Australia

Awards

Research Award

Year Award
2005 Dudley Homer Vose award
National Heart Foundation of Australia
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Book (5 outputs)

Year Citation Altmetrics Link
2004 D'Este CA, Byles JE, Attia JR, Brown AM, Second Mortality and Cancer Incidence Report, -, Newcastle, Australia (2004) [A2]
Co-authors Julie Byles, Catherine Deste, Meredith Tavener
2004 D'Este CA, Byles JE, Attia JR, Brown AM, Report on the General Health and Medical Study, -, Newcastle, Australia, 463 (2004) [A2]
Co-authors Meredith Tavener, Catherine Deste, Julie Byles
2003 D'Este CA, Byles JE, Attia JR, Brown AM, Literature Review Report, -, Newcastle, Australia (2003) [A2]
Co-authors Meredith Tavener, Julie Byles, Catherine Deste
2003 D'Este CA, Byles JE, Attia JR, Brown AM, Report on the qualitative interviews, -, Newcastle, Australia (2003) [A2]
Co-authors Catherine Deste, Julie Byles, Meredith Tavener
2003 D'Este CA, Byles JE, Attia JR, Brown AM, Interim mortality and cancer incidence report, -, Newcastle, Australia (2003) [A2]
Co-authors Julie Byles, Catherine Deste, Meredith Tavener
Show 2 more books

Chapter (6 outputs)

Year Citation Altmetrics Link
2017 Maguire JM, Holliday EG, Oldmeadow C, Attia J, Henderson MPA, Pare G, 'Genetic Association Studies and Next Generation Sequencing in Stroke: Methods', Stroke Genetics, Springer International Publishing, London (2017)
Co-authors Christopher Oldmeadow, Liz Holliday
2015 Riveros C, Vimieiro R, Holliday EG, Oldmeadow C, Wang JJ, Mitchell P, et al., 'Identification of genome-wide SNP-SNP and SNP-clinical Boolean interactions in Age-related Macular Degeneration', Epistasis: Methods and Protocols, Springer, New York 217-255 (2015) [B1]
DOI 10.1007/978-1-4939-2155-3_12
Citations Scopus - 2
Co-authors Rodney Scott, Pablo Moscato, Christopher Oldmeadow, Liz Holliday, Carlos Riveros
2014 Attia JR, Holliday EG, Ioannidis JPA, Thakkinstian A, McEvoy M, Scott RJ, et al., 'How to use an article about genetic association', Users' Guides to the Medical Literature: Essentials of Evidence-Based Clinical Practice 3e, McGraw Hill Professional, USA (2014)
Co-authors Liz Holliday, Rodney Scott
2013 Holliday EG, Oldmeadow CJ, Maguire JM, Attia JR, 'Candidate gene association studies in stroke', Stroke Genetics, Springer Verlag, London 9-23 (2013) [B1]
Citations Scopus - 1
Co-authors Liz Holliday, Christopher Oldmeadow
2011 Attia JR, 'Moving beyond sensitivity and specificity: Using likelihood ratios to help interpret diagnostic tests', Abnormal Laboratory Results, McGraw Hill, North Ryde, NSW 23-29 (2011) [B2]
2002 Jaeschke R, Guyatt G, Barratt A, Walter S, McAlister F, Attia JR, 'Part 2: Beyond the basics. Therapy and understanding the results. Measures of association', Users' guides to the medical literature : a manual for evidence-based clinical practice, AMA Press, Chicago, Ill. 706 (2002) [B2]
Show 3 more chapters

Journal article (499 outputs)

Year Citation Altmetrics Link
2017 Goodsall TM, Flynn P, Attia JR, 'The scratch test for determining the inferior hepatic margin', MEDICAL JOURNAL OF AUSTRALIA, 206 386-388 (2017) [C1]
DOI 10.5694/mja16.01068
2017 Smith SR, Pockney P, Holmes R, Doig F, Attia J, Holliday E, et al., 'Biomarkers and anastomotic leakage in colorectal surgery: C-reactive protein trajectory is the gold standard.', ANZ J Surg, (2017)
DOI 10.1111/ans.13937
Co-authors Peter Pockney
2017 Kepreotes E, Whitehead B, Attia J, Oldmeadow C, Collison A, Searles A, et al., 'High-flow warm humidified oxygen versus standard low-flow nasal cannula oxygen for moderate bronchiolitis (HFWHO RCT): an open, phase 4, randomised controlled trial', The Lancet, 389 930-939 (2017)

© 2017 Elsevier Ltd Background Bronchiolitis is the most common lung infection in infants and treatment focuses on management of respiratory distress and hypoxia. High-flow warm ... [more]

© 2017 Elsevier Ltd Background Bronchiolitis is the most common lung infection in infants and treatment focuses on management of respiratory distress and hypoxia. High-flow warm humidified oxygen (HFWHO) is increasingly used, but has not been rigorously studied in randomised trials. We aimed to examine whether HFWHO provided enhanced respiratory support, thereby shortening time to weaning off oxygen. Methods In this open, phase 4, randomised controlled trial, we recruited children aged less than 24 months with moderate bronchiolitis attending the emergency department of the John Hunter Hospital or the medical unit of the John Hunter Children's Hospital in New South Wales, Australia. Patients were randomly allocated (1:1) via opaque sealed envelopes to HFWHO (maximum flow of 1 L/kg per min to a limit of 20 L/min using 1:1 air¿oxygen ratio, resulting in a maximum FiO 2 of 0·6) or standard therapy (cold wall oxygen 100% via infant nasal cannulae at low flow to a maximum of 2 L/min) using a block size of four and stratifying for gestational age at birth. The primary outcome was time from ran domisation to last use of oxygen therapy. All randomised children were included in the primary and secondary safety analyses. This trial is registered with the Australian New Zealand Clinical Trials Registry, number ACTRN12612000685819. Findings From July 16, 2012, to May 1, 2015, we randomly assigned 202 children to either HFWHO (101 children) or standard therapy (101 children). Median time to weaning was 24 h (95% CI 18¿28) for standard therapy and 20 h (95% CI 17¿34) for HFWHO (hazard ratio [HR] for difference in survival distributions 0·9 [95% CI 0·7¿1·2] ; log rank p=0·61). Fewer children experienced treatment failure on HFWHO (14 [14%]) compared with standard therapy (33 [33%] ; p=0·0016); of these children, those on HFWHO were supported for longer than were those on standard therapy before treatment failure (HR 0·3; 95% CI 0·2¿0·6; p < 0·0001). 20 (61%) of 33 children who experienced treatment failure on standard therapy were rescued with HFWHO. 12 (12%) of children on standard therapy required transfer to the intensive care unit compared with 14 (14%) of those on HFWHO (difference -1%; 95% CI -7 to 16; p=0·41). Four adverse events occurred (oxygen desaturation and condensation inhalation in the HFWHO group, and two incidences of oxygen tubing disconnection in the standard therapy group); none resulted in withdrawal from the trial. No oxygen-related serious adverse events occurred. Secondary effectiveness outcomes are reported in the Results section. Interpretation HFWHO did not significantly reduce time on oxygen compared with standard therapy, suggesting that early use of HFWHO does not modify the underlying disease process in moderately severe bronchiolitis. HFWHO might have a role as a rescue therapy to reduce the proportion of children requiring high-cost intensive care. Funding Hunter Children's Research Foundation, John Hunter Hospital Charitable Trust, and the University of Newcastle Priority Research Centre GrowUpWell.

DOI 10.1016/S0140-6736(17)30061-2
Citations Scopus - 2Web of Science - 3
Co-authors Adam Collison, Christopher Oldmeadow, Joerg Mattes
2017 Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, et al., 'Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.', Hypertension, (2017)
DOI 10.1161/HYPERTENSIONAHA.117.09438
Co-authors Liz Holliday, Christopher Oldmeadow, Rodney Scott
2017 Willems SM, Wright DJ, Day FR, Trajanoska K, Joshi PK, Morris JA, et al., 'Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness', Nature Communications, 8 (2017)

© The Author(s) 2017. Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To inve... [more]

© The Author(s) 2017. Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (P < 5 × 10 -8 ) in combined analyses. A number of these loci contain genes implicated in structure and function of skeletal muscle fibres (ACTG1), neuronal maintenance and signal transduction (PEX14, TGFA, SYT1), or monogenic syndromes with involvement of psychomotor impairment (PEX14, LRPPRC and KANSL1). Mendelian randomization analyses are consistent with a causal effect of higher genetically predicted grip strength on lower fracture risk. In conclusion, our findings provide new biological insight into the mechanistic underpinnings of grip strength and the causal role of muscular strength in age-related morbidities and mortality.

DOI 10.1038/ncomms16015
Citations Scopus - 1
Co-authors Christopher Oldmeadow
2017 Joshi T, Oldmeadow C, Attia J, Wynne K, 'The duration of intrapartum maternal hyperglycaemia predicts neonatal hypoglycaemia in women with pre-existing diabetes.', Diabet Med, 34 725-731 (2017)
DOI 10.1111/dme.13337
Co-authors Christopher Oldmeadow
2017 Jones MP, Attia JR, 'Sampling: how you choose people is as important as how you analyse their data.', Med J Aust, 206 67-68 (2017)
2017 McCrabb S, Baker AL, Attia J, Balogh ZJ, Lott N, Naylor J, et al., 'Smoke-Free Recovery from Trauma Surgery: A Pilot Trial of an Online Smoking Cessation Program for Orthopaedic Trauma Patients.', Int J Environ Res Public Health, 14 (2017)
DOI 10.3390/ijerph14080847
Co-authors Zsolt Balogh, Billie Bonevski, Luke Wolfenden, Amanda Baker
2017 Attia JR, Jones MP, Hure A, 'Deconfounding confounding part 1: traditional explanations', MEDICAL JOURNAL OF AUSTRALIA, 206 244-+ (2017)
DOI 10.5694/mja16.00491
Citations Web of Science - 1
Co-authors Alexis Hure
2017 Lai JS, Hure AJ, Oldmeadow C, McEvoy M, Byles J, Attia J, 'Prospective study on the association between diet quality and depression in mid-aged women over 9¿years', European Journal of Nutrition, 56 273-281 (2017)

© 2015, Springer-Verlag Berlin Heidelberg. Purpose: To examine the longitudinal association between diet quality and depression using prospective data from the Australian Longitu... [more]

© 2015, Springer-Verlag Berlin Heidelberg. Purpose: To examine the longitudinal association between diet quality and depression using prospective data from the Australian Longitudinal Study on Women¿s Health. Methods: Women born in 1946¿1951 (n¿=¿7877) were followed over 9¿years starting from 2001. Dietary intake was assessed using the Dietary Questionnaire for Epidemiological Studies (version 2) in 2001 and a shortened form in 2007 and 2010. Diet quality was summarised using the Australian Recommended Food Score. Depression was measured using the 10-item Centre for Epidemiologic Depression Scale and self-reported physician diagnosis. Pooled logistic regression models including time-varying covariates were used to examine associations between diet quality tertiles and depression. Women were also categorised based on changes in diet quality during 2001¿2007. Analyses were adjusted for potential confounders. Results: The highest tertile of diet quality was associated marginally with lower odds of depression (OR 0.94; 95¿% CI 0.83, 1.00; P¿=¿0.049) although no significant linear trend was observed across tertiles (OR 1.00; 95¿% CI 0.94, 1.10; P¿=¿0.48). Women who maintained a moderate or high score over 6¿years had a 6¿14¿% reduced odds of depression compared with women who maintained a low score (moderate vs low score¿OR 0.94; 95¿% CI 0.80, 0.99; P¿=¿0.045; high vs low score¿OR 0.86; 95¿% CI 0.77, 0.96; P¿=¿0.01). Similar results were observed in analyses excluding women with prior history of depression. Conclusion: Long-term maintenance of good diet quality may be associated with reduced odds of depression. Randomised controlled trials are needed to eliminate the possibility of residual confounding.

DOI 10.1007/s00394-015-1078-8
Citations Scopus - 1Web of Science - 1
Co-authors Christopher Oldmeadow, Mark Mcevoy, Alexis Hure, Julie Byles
2017 Dunlop AJ, Brown AL, Oldmeadow C, Harris A, Gill A, Sadler C, et al., 'Effectiveness and cost-effectiveness of unsupervised buprenorphine-naloxone for the treatment of heroin dependence in a randomized waitlist controlled trial', Drug and Alcohol Dependence, 174 181-191 (2017) [C1]

© 2017 Background Access to opioid agonist treatment can be associated with extensive waiting periods with significant health and financial burdens. This study aimed to determine... [more]

© 2017 Background Access to opioid agonist treatment can be associated with extensive waiting periods with significant health and financial burdens. This study aimed to determine whether patients with heroin dependence dispensed buprenorphine-naloxone weekly have greater reductions in heroin use and related adverse health effects 12-weeks after commencing treatment, compared to waitlist controls and to examine the cost-effectiveness of this strategy. Methods An open-label waitlist RCT was conducted in an opioid treatment clinic in Newcastle, Australia. Fifty patients with DSM-IV-TR heroin dependence (and no other substance dependence) were recruited. The intervention group (n = 25) received take-home self-administered sublingual buprenorphine-naloxone weekly (mean dose, 22.7 ± 5.7 mg) and weekly clinical review. Waitlist controls (n = 25) received no clinical intervention. The primary outcome was heroin use (self-report, urine toxicology verified) at weeks four, eight and 12. The primary cost-effectiveness outcome was incremental cost per additional heroin-free-day. Results Outcome data were available for 80% of all randomized participants. Across the 12-weeks, treatment group heroin use was on average 19.02 days less/month (95% CI -22.98, -15.06, p < 0.0001). A total 12-week reduction in adjusted costs including crime of $A5,722 (95% CI 3299, 8154) in favor of treatment was observed. Excluding crime, incremental cost per heroin-free-day gained from treatment was $A18.24 (95% CI 4.50, 28.49). Conclusion When compared to remaining on a waitlist, take-home self-administered buprenorphine-naloxone treatment is associated with significant reductions in heroin use for people with DSM-IV-TR heroin dependence. This cost-effective approach may be an efficient strategy to enhance treatment capacity.

DOI 10.1016/j.drugalcdep.2017.01.016
Co-authors Christopher Oldmeadow, A Dunlop
2017 Khaing W, Vallibhakara SA, Attia J, McEvoy M, Thakkinstian A, 'Effects of education and income on cardiovascular outcomes: A systematic review and meta-analysis', European Journal of Preventive Cardiology, 24 1032-1042 (2017) [C1]

© European Society of Cardiology. Objective Previous studies have reported discrepancy effects of education and income on cardiovascular diseases. This systematic review and meta... [more]

© European Society of Cardiology. Objective Previous studies have reported discrepancy effects of education and income on cardiovascular diseases. This systematic review and meta-analysis was therefore conducted which aimed to summarize effects of education and income on cardiovascular diseases. Methods Studies were identified from Medline and Scopus until July 2016. Cohorts were eligible if they assessed associations between education/income and cardiovascular diseases, had at least one outcome including coronary artery diseases, cardiovascular events, strokes and cardiovascular deaths. A multivariate meta-analysis was applied to pool risk effects of these social determinants. Results Among 72 included cohorts, 39, 19, and 14 were studied in Europe, USA, and Asia. Pooled risk ratios of low and medium versus high education were 1.36 (95% confidence interval: 1.11-1.66) and 1.21 (1.06-1.40) for coronary artery diseases, 1.50 (1.17-1.92) and 1.27 (1.09-1.48) for cardiovascular events, 1.23 (1.06-1.43) and 1.17 (1.01-1.35) for strokes, and 1.39 (1.26-1.54) and 1.21 (1.12-1.30) for cardiovascular deaths. The effects of education on all cardiovascular diseases were still present in US and Europe settings, except in Asia this was present only for cardiovascular deaths. Effects of low and medium income versus high on these corresponding cardiovascular diseases were 1.49 (1.16-1.91) and 1.27 (1.10-1.47) for coronary art ery diseases, 1.17 (0.96-1.44) and 1.05 (0.98-1.13) for cardiovascular events, 1.30 (0.99-1.72) and 1.24 (1.00-1.53) for strokes, and 1.76 (1.45-2.14) and 1.34 (1.17-1.54) for cardiovascular deaths. Conclusion Social determinants are risk factors of cardiovascular diseases in developed countries, although high heterogeneity in pooling. Data in Asia countries are still needed to update pooling.

DOI 10.1177/2047487317705916
Citations Scopus - 1Web of Science - 1
Co-authors Mark Mcevoy
2017 Vejakama P, Ingsathit A, McEvoy M, Attia J, Thakkinstian A, 'Progression of chronic kidney disease: an illness-death model approach.', BMC Nephrol, 18 205 (2017)
DOI 10.1186/s12882-017-0604-8
Co-authors Mark Mcevoy
2017 Attia JR, Oldmeadow C, Holliday EG, Jones MP, 'Deconfounding confounding part 2: using directed acyclic graphs (DAGs)', MEDICAL JOURNAL OF AUSTRALIA, 206 480-+ (2017)
DOI 10.5694/mja16.01167
Co-authors Christopher Oldmeadow, Liz Holliday
2017 Sharmin S, Kypri K, Khanam M, Wadolowski M, Bruno R, Attia J, et al., 'Effects of parental alcohol rules on risky drinking and related problems in adolescence: Systematic review and meta-analysis', DRUG AND ALCOHOL DEPENDENCE, 178 243-256 (2017) [C1]
DOI 10.1016/j.drugalcdep.2017.05.011
Co-authors Liz Holliday, Kypros Kypri
2017 Gleeson M, Pyne DB, Elkington LJ, Hall ST, Attia JR, Oldmeadow C, et al., 'Developing a multi-component immune model for evalusating the risk of respiratory illness in athletes', EXERCISE IMMUNOLOGY REVIEW, 23 52-64 (2017) [C1]
Co-authors Sharron Hall, Robin Callister, Christopher Oldmeadow, Lisa Wood, Maree Gleeson
2017 Lertpimonchai A, Rattanasiri S, Arj-Ong Vallibhakara S, Attia J, Thakkinstian A, 'The association between oral hygiene and periodontitis: a systematic review and meta-analysis.', Int Dent J, (2017)
DOI 10.1111/idj.12317
2017 Korda RJ, Soga K, Joshy G, Calabria B, Attia J, Wong D, Banks E, 'Socioeconomic variation in incidence of primary and secondary major cardiovascular disease events: an Australian population-based prospective cohort study (vol 15, 189, 2016)', INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH, 16 (2017)
DOI 10.1186/s12939-016-0502-x
2017 Thibault P, Attia J, Oldmeadow C, 'A prolonged antibiotic protocol to treat persistent Chlamydophila pneumoniae infection improves the extracranial venous circulation in multiple sclerosis.', Phlebology, 268355517712884 (2017)
DOI 10.1177/0268355517712884
Co-authors Christopher Oldmeadow
2017 Iseme RA, McEvoy M, Kelly B, Agnew L, Walker FR, Handley T, et al., 'A role for autoantibodies in atherogenesis', CARDIOVASCULAR RESEARCH, 113 1102-1112 (2017) [C1]
DOI 10.1093/cvr/cvx112
Co-authors Christopher Oldmeadow, Brian Kelly, Rohan Walker, Mark Mcevoy
2017 Joachim N, Colijn JM, Kifley A, Lee KE, Buitendijk GHS, Klein BEK, et al., 'Five-year progression of unilateral age-related macular degeneration to bilateral involvement: the Three Continent AMD Consortium report.', Br J Ophthalmol, 101 1185-1192 (2017)
DOI 10.1136/bjophthalmol-2016-309729
Co-authors Liz Holliday
2017 Boonchan T, Wilasrusmee C, McEvoy M, Attia J, Thakkinstian A, 'Network meta-analysis of antibiotic prophylaxis for prevention of surgical-site infection after groin hernia surgery.', Br J Surg, 104 e106-e117 (2017)
DOI 10.1002/bjs.10441
Co-authors Mark Mcevoy
2017 Hodder RK, Freund M, Bowman J, Wolfenden L, Campbell E, Dray J, et al., 'Effectiveness of a pragmatic school-based universal resilience intervention in reducing tobacco, alcohol and illicit substance use in a population of adolescents: cluster-randomised controlled trial.', BMJ Open, 7 e016060 (2017)
DOI 10.1136/bmjopen-2017-016060
Co-authors Jenny Bowman, Luke Wolfenden, Rebecca Hodder, Julia Dray Uon, Christopher Oldmeadow
2017 Dray J, Bowman J, Campbell E, Freund M, Hodder R, Wolfenden L, et al., 'Effectiveness of a pragmatic school-based universal intervention targeting student resilience protective factors in reducing mental health problems in adolescents', Journal of Adolescence, 57 74-89 (2017) [C1]

© 2017 The Authors Worldwide, 10¿20% of adolescents experience mental health problems. Strategies aimed at strengthening resilience protective factors provide a potential approa... [more]

© 2017 The Authors Worldwide, 10¿20% of adolescents experience mental health problems. Strategies aimed at strengthening resilience protective factors provide a potential approach for reducing mental health problems in adolescents. This study evaluated the effectiveness of a universal, school-based intervention targeting resilience protective factors in reducing mental health problems in adolescents. A cluster randomised controlled trial was conducted in 20 intervention and 12 control secondary schools located in socio-economically disadvantaged areas of NSW, Australia. Data were collected from 3115 students at baseline (Grade 7, 2011), of whom 2149 provided data at follow up (Grade 10, 2014; enrolments in Grades 7 to 10 typically aged 12¿16 years; 50% male; 69.0% retention). There were no significant differences between groups at follow-up for three mental health outcomes: total SDQ, internalising problems, and prosocial behaviour. A small statistically significant difference in favour of the control group was found for externalising problems. Findings highlight the continued difficulties in developing effective, school-based prevention programs for mental health problems in adolescents. Trial registration ANZCTR (Ref no: ACTRN12611000606987).

DOI 10.1016/j.adolescence.2017.03.009
Co-authors Christopher Oldmeadow, Jenny Bowman, Luke Wolfenden, Julia Dray Uon, John Wiggers, Rebecca Hodder
2017 Jones MP, Walker MM, Attia JR, 'Understanding statistical principles in correlation, causation and moderation in human disease', Medical Journal of Australia, 207 104-106.e1 (2017) [C1]
DOI 10.5694/mja16.00697
Citations Web of Science - 1
Co-authors Marjorie Walker
2017 Ewald BD, Oldmeadow C, Attia JR, 'Daily step count and the need for hospital care in subsequent years in a community-based sample of older australians', Medical Journal of Australia, 206 126-130 (2017) [C1]

© 2017 AMPCo Pty Ltd. Produced with Elsevier B.V. All rights reserved. Objectives: To determine the extent to which physical activity reduces the number of hospital bed-days for ... [more]

© 2017 AMPCo Pty Ltd. Produced with Elsevier B.V. All rights reserved. Objectives: To determine the extent to which physical activity reduces the number of hospital bed-days for Australians over 55, using an objective measure of activity. Design, setting and participants: 9784 Newcastle residents aged 55 years or more were invited to participate. 3253 responders were eligible and wore pedometers for one week during 2005e2007; their hospital data from recruitment to 31 March 2015 were analysed (mean follow-up time: 8.2 years). Complete data for 2110 people were available for analysis. Main outcome measures: Mean annual hospital bed-days, according to individual step count. Results: There was a statistically significant reduction in the number of hospital bed-days associated with higher step counts; the incidence rate ratio per extra 1000 steps per day at baseline was 0.91 (95% CI, 0.90e0.94). The disease-specific reductions were significant for admissions for cancer and diabetes, but not for cardiovascular disease. The difference between 4500 and 8800 steps per day (the upper and lower quartile boundaries for step count) was 0.36 bed-days per person per year, after adjusting for age, sex, number of medications, number of comorbidities, smoking and alcohol status, and education. When analysis was restricted to hospital admissions after the first 2 years of follow-up, the difference was 0.29 bed-days per person per year. Conclusions: More active people require less hospital care, and an achievable extra 4300 steps per day would result in an average of one less day in hospital for each 3 years of life.

DOI 10.5694/mja16.00640
Citations Scopus - 2Web of Science - 2
Co-authors Ben Ewald, Christopher Oldmeadow
2017 Malik R, Dau T, Gonik M, Sivakumar A, Deredge DJ, Edeleva EV, et al., 'Common coding variant in SERPINA1 increases the risk for large artery stroke', Proceedings of the National Academy of Sciences of the United States of America, 114 3613-3618 (2017) [C1]

Large artery atherosclerotic stroke (LAS) shows substantial heritability not explained by previous genome-wide association studies. Here, we explore the role of coding variation i... [more]

Large artery atherosclerotic stroke (LAS) shows substantial heritability not explained by previous genome-wide association studies. Here, we explore the role of coding variation in LAS by analyzing variants on the HumanExome BeadChip in a total of 3,127 cases and 9,778 controls from Europe, Australia, and South Asia. We report on a nonsynonymous single-nucleotide variant in serpin family A member 1 (SERPINA1) encoding alpha-1 antitrypsin [AAT; p.V213A; P = 5.99E-9, odds ratio (OR) = 1.22] and confirm histone deacetylase 9 (HDAC9) as a major risk gene for LAS with an association in the 3?-UTR (rs2023938; P = 7.76E-7, OR = 1.28). Using quantitative microscale thermophoresis, we show that M1 (A213) exhibits an almost twofold lower dissociation constant with its primary target human neutrophil elastase (NE) in lipoprotein-containing plasma, but not in lipid-free plasma. Hydrogen/deuterium exchange combined with mass spectrometry further revealed a significant difference in the global flexibility of the two variants. The observed stronger interaction with lipoproteins in plasma and reduced global flexibility of the Val-213 variant most likely improve its local availability and reduce the extent of proteolytic inactivation by other proteases in atherosclerotic plaques. Our results indicate that the interplay between AAT, NE, and lipoprotein particles is modulated by the gate region around position 213 in AAT, far away from the unaltered reactive center loop (357-360). Collectively, our findings point to a functionally relevant balance between lipoproteins, proteases, and AAT in atherosclerosis.

DOI 10.1073/pnas.1616301114
Citations Scopus - 2Web of Science - 1
Co-authors Christopher Levi, Liz Holliday, Lisa Lincz
2017 Rowe CW, Haider AS, Viswanathan D, Jones M, Attia J, Wynne K, Acharya S, 'Insulin resistance correlates with maculopathy and severity of retinopathy in young adults with Type 1 Diabetes Mellitus', Diabetes Research and Clinical Practice, 131 154-160 (2017)
DOI 10.1016/j.diabres.2017.06.022
Co-authors Christopher W Rowe Uon
2017 Harris ML, Oldmeadow C, Hure A, Luu J, Loxton D, Attia J, 'Stress increases the risk of type 2 diabetes onset in women: A 12-year longitudinal study using causal modelling.', PLoS One, 12 e0172126 (2017)
DOI 10.1371/journal.pone.0172126
Co-authors Melissa Harris, Christopher Oldmeadow, Alexis Hure, Deborah Loxton
2017 Schmidt AF, Swerdlow DI, Holmes MV, Patel RS, Fairhurst-Hunter Z, Lyall DM, et al., 'PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study', The Lancet Diabetes and Endocrinology, 5 97-105 (2017)

© 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Background Statin treatment and variants in the gene encoding HMG-CoA redu... [more]

© 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Background Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way offsets their substantial benefits. We sought to investigate the associations of LDL cholesterol-lowering PCSK9 variants with type 2 diabetes and related biomarkers to gauge the likely effects of PCSK9 inhibitors on diabetes risk. Methods In this mendelian randomisation study, we used data from cohort studies, randomised controlled trials, case control studies, and genetic consortia to estimate associations of PCSK9 genetic variants with LDL cholesterol, fasting blood glucose, HbA 1c , fasting insulin, bodyweight, waist-to-hip ratio, BMI, and risk of type 2 diabetes, using a standardised analysis plan, meta-analyses, and weighted gene-centric scores. Findings Data were available for more than 550¿000 individuals and 51¿623 cases of type 2 diabetes. Combined analyses of four independent PCSK9 variants (rs11583680, rs11591147, rs2479409, and rs11206510) scaled to 1 mmol/L lower LDL cholesterol showed associations with increased fasting glucose (0·09 mmol/L, 95% CI 0·02 to 0·15), bodyweight (1·03 kg, 0·24 to 1·82), waist-to-hip ratio (0·006, 0·003 to 0·010), and an odds ratio for type diabetes of 1·29 (1·11 to 1·50). Based on the collected data, we did not identify associations with HbA 1c (0·03%, -0·01 to 0·08), fasting insulin (0·00%, -0·06 to 0·07), and BMI (0·11 kg/m 2 , -0·09 to 0·30). Interpretation PCSK9 variants associated with lower LDL cholesterol were also associated with circulating higher fasting glucose concentration, bodyweight, and waist-to-hip ratio, and an increased risk of type 2 diabetes. In trials of PCSK9 inhibitor drugs, investigators should carefully assess these safety outcomes and quantify the risks and benefits of PCSK9 inhibitor treatment, as was previously done for statins. Funding British Heart Foundation, and University College London Hospitals NHS Foundation Trust (UCLH) National Institute for Health Research (NIHR) Biomedical Research Centre.

DOI 10.1016/S2213-8587(16)30396-5
Citations Scopus - 16Web of Science - 19
Co-authors Liz Holliday
2017 Paterson MA, Smart CEM, Lopez PE, Howley P, McElduff P, Attia J, et al., 'Increasing the protein quantity in a meal results in dose-dependent effects on postprandial glucose levels in individuals with Type 1 diabetes mellitus.', Diabet Med, 34 851-854 (2017)
DOI 10.1111/dme.13347
Co-authors Peter Howley, Bruce King, Patrick Mcelduff
2017 de Vries PS, Sabater-Lleal M, Chasman DI, Trompet S, Ahluwalia TS, Teumer A, et al., 'Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study', PLOS ONE, 12 (2017) [C1]
DOI 10.1371/journal.pone.0167742
Co-authors Mark Mcevoy, Rodney Scott, Liz Holliday, Christopher Oldmeadow
2017 Zhang X, Khan AA, Haq EU, Rahim A, Hu D, Attia J, et al., 'Increasing mortality from ischaemic heart disease in China from 2004 to 2010: disproportionate rise in rural areas and elderly subjects. 438 million person-years follow-up.', Eur Heart J Qual Care Clin Outcomes, 3 47-52 (2017)
DOI 10.1093/ehjqcco/qcw041
Co-authors Christopher Oldmeadow
2017 Jones MP, Beath A, Oldmeadow C, Attia JR, 'Understanding statistical hypothesis tests and power.', Med J Aust, 207 148-150 (2017) [C1]
Citations Web of Science - 1
Co-authors Christopher Oldmeadow
2017 Thomson D, Cowan T, Loten C, Botfield C, Holliday E, Attia J, 'High-flow oxygen in patients undergoing procedural sedation in the emergency department: A retrospective chart review', EMA - Emergency Medicine Australasia, 29 33-39 (2017)

© 2016 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine Objective: Hypoxia is a recognised complication of procedural sedation. This st... [more]

© 2016 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine Objective: Hypoxia is a recognised complication of procedural sedation. This study sought to determine whether there was an association between the use of high-flow oxygen delivery by a non-rebreather (NRB) mask during ED procedural sedation and decreased rates of hypoxia when compared with alternative oxygenation methods. Methods: Records of all procedural sedations performed over a 12 month period in an Australian tertiary ED were reviewed retrospectively. The primary outcome was whether recorded oxygen saturations fell below 90%. Specifics of the oxygen delivery method were noted and data collected included sex, age, indication for sedation, drugs and doses administered, time of day sedation was commenced and staff grade of sedationist. Results: A total of 755 procedural sedations were reviewed. Two hundred and five (27.1%) patients were administered oxygen via NRB mask from the outset of their sedation. NRB administration was associated with a statistically significant decreased rate of hypoxia (1/205 patients vs 23/550 [odds ratio: 0.112; 95% confidence interval: 0.003¿0.0702]; P = 0.0090). This association remained statistically significant when adjusted for confounders. Conclusions: This study demonstrates an association with a statistically significant reduction in hypoxia when high-flow oxygen via NRB mask is administered during emergency procedural sedation. This intervention is simple, safe and inexpensive, and we would advocate that it be evaluated further in prospective trials.

DOI 10.1111/1742-6723.12687
Co-authors Liz Holliday
2017 Pattanaprateep O, McEvoy M, Attia J, Thakkinstian A, 'Evaluation of rational nonsteroidal anti-inflammatory drugs and gastro-protective agents use; association rule data mining using outpatient prescription patterns', BMC MEDICAL INFORMATICS AND DECISION MAKING, 17 (2017) [C1]
DOI 10.1186/s12911-017-0496-3
Co-authors Mark Mcevoy
2017 Daneshi N, Holliday E, Hancock S, Schneider JJ, Scott RJ, Attia J, Milward EA, 'Prevalence of clinically actionable genotypes and medication exposure of older adults in the community', PHARMACOGENOMICS & PERSONALIZED MEDICINE, 10 17-27 (2017)
DOI 10.2147/PGPM.S123719
Co-authors Jennifer Schneider, Rodney Scott, Liz Milward, Liz Holliday
2017 McCrabb S, Baker AL, Attia J, Balogh ZJ, Lott N, Palazzi K, et al., 'Who is More Likely to Use the Internet for Health Behavior Change? A Cross-Sectional Survey of Internet Use Among Smokers and Nonsmokers Who Are Orthopedic Trauma Patients.', JMIR Ment Health, 4 e18 (2017) [C1]
DOI 10.2196/mental.7435
Co-authors Amanda Baker, Billie Bonevski, Zsolt Balogh, Luke Wolfenden
2017 McCrabb S, Balogh Z, Baker AL, Harris IA, Attia J, Lott N, et al., 'Development of an online smoking cessation program for use in hospital and following discharge: Smoke-free recovery', BMJ Innovations, 3 115-122 (2017) [C1]

© 2017, BMJ Publishing Group. All rights reserved. Background Tobacco smoking can have negative health outcomes on recovery from surgery. Although it is recommended best practice... [more]

© 2017, BMJ Publishing Group. All rights reserved. Background Tobacco smoking can have negative health outcomes on recovery from surgery. Although it is recommended best practice to provide patients with advice to quit and follow-up support, provision of postdischarge support is rare. Developing an online smoking cessation program may help address this gap. Objectives This paper describes the development and pretesting of an online smoking cessation program (smoke-free recovery, SFR) tailored to the orthopaedic trauma population for use while in hospital and post-discharge. Methods Drawing on the DoTTI framework for developing an online program, the following steps were followed for program development: (1) design and development; (2) testing early iteration; (3) testing for effectiveness and (4) integration and implementation. This article describes the first two stages of SFR program development. Results SFR is a 10-module online smoking cessation program tailored for patients with orthopaedic trauma. Of the participants who completed testing early iterations, none reported any difficulties orientating themselves to the program or understanding program content. The main themes were that it was ¿helpful¿, provision of ¿help to quit¿ was low and SFR increased thoughts of ¿staying quit post discharge¿. Conclusions This study found that a theory and evidence-based approach as the basis for an online smoking cessation program for patients with orthopaedic trauma was acceptable to users. A randomised controlled trial will be conducted to examine whether the online smoking cessation program is effective in increasing smoking cessation and how it can be integrated and implemented into hospital practice (stages three and four of the DoTTI framework).

DOI 10.1136/bmjinnov-2016-000126
Citations Scopus - 1
Co-authors Amanda Baker, Frans Henskens, Billie Bonevski, Luke Wolfenden, Mark Wallis, Zsolt Balogh
2017 McCrabb S, Baker AL, Attia J, Balogh ZJ, Lott N, Palazzi K, et al., 'Smoking, Quitting, and the Provision of Smoking Cessation Support: A Survey of Orthopaedic Trauma Patients.', J Orthop Trauma, 31 e255-e262 (2017)
DOI 10.1097/BOT.0000000000000872
Co-authors Zsolt Balogh, Amanda Baker, Billie Bonevski, Luke Wolfenden
2017 Bivard A, Lillicrap T, Krishnamurthy V, Holliday E, Attia J, Pagram H, et al., 'MIDAS (Modafinil in Debilitating Fatigue After Stroke): A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial.', Stroke, 48 1293-1298 (2017)
DOI 10.1161/STROKEAHA.116.016293
Co-authors Andrew Bivard, Michael Nilsson, Mark Parsons, Christopher Levi, Liz Holliday
2017 Fealy SM, Taylor RM, Foureur M, Attia J, Ebert L, Bisquera A, Hure AJ, 'Weighing as a stand-alone intervention does not reduce excessive gestational weight gain compared to routine antenatal care: a systematic review and meta-analysis of randomised controlled trials.', BMC Pregnancy Childbirth, 17 36 (2017)
DOI 10.1186/s12884-016-1207-2
Co-authors Alexis Hure, Shanna Fealy, Lyn Ebert
2017 Thomas LC, Hall LA, Attia JR, Holliday EG, Markus HS, Levi CR, 'Seasonal Variation in Spontaneous Cervical Artery Dissection: Comparing between UK and Australian Sites', Journal of Stroke and Cerebrovascular Diseases, 26 177-185 (2017)

© 2017 National Stroke Association Background Cervical artery dissection (CAD) is a lea ding cause of stroke among middle-aged adults, but the etiology is unclear. Some reports o... [more]

© 2017 National Stroke Association Background Cervical artery dissection (CAD) is a lea ding cause of stroke among middle-aged adults, but the etiology is unclear. Some reports of seasonal variation in CAD incidence have been suggested but may reflect extreme climatic conditions. Seasonal variation may implicate more transient seasonal causes such as proinflammatory or hypercoagulable states. This study aimed to assess whether CAD incidence varied with season between UK and Australian sites. Also, this study aimed to determine whether there was a different pattern of seasonal variation between arteries (carotid and vertebral) and any association between CAD incidence and clinical factors. Methods This was a retrospective observational study of patients older than 18 years with radiological diagnosis of internal carotid or vertebral arterial dissection, from sites in Australia and the UK. Clinical variables were compared between autumn-winter and spring-summer and site of dissection. Results A total of 133 CAD cases were documented in Australia and 242 in the UK. There was a seasonal pattern to CAD incidence in countries in both the northern and the southern hemispheres, with a trend for dissection to occur more commonly in autumn, winter, and spring than in summer (incidence rate ratios [IRR] 1.4-1.5, P¿ < ¿.05). CAD counts were also slightly higher in internal carotid than in vertebral artery (IRRs 1.168, 1.43, and 1.127, respectively). Neither systolic blood pressure nor pulse pressure was significantly associated with CAD counts. Conclusions CAD occurs more commonly in cooler months regardless of geographical location, suggesting transient seasonal causes may be important in the pathophysiology. This effect was slightly higher in internal carotid than in vertebral artery, suggesting differing trigger mechanisms between dissection sites.

DOI 10.1016/j.jstrokecerebrovasdis.2016.09.006
Co-authors Christopher Levi, Liz Holliday, Lucy Thomas
2017 Clover KA, Rogers KM, Britton B, Oldmeadow C, Attia J, Carter GL, 'Reduced prevalence of pain and distress during 4¿years of screening with QUICATOUCH in Australian oncology patients.', Eur J Cancer Care (Engl), (2017)
DOI 10.1111/ecc.12636
Co-authors Christopher Oldmeadow, Gregory Carter
2017 Laver DR, Attia J, Oldmeadow C, Quail AW, 'Cardiac Calcium Release Channel (Ryanodine Receptor 2) Regulation by Halogenated Anesthetics', Anesthesiology, 126 495-506 (2017) [C1]

© 2017, the American Society of Anesthesiologists, Inc. Wolters Kluwer Health, Inc. All Rights Reserved. Background: Halogenated anesthetics activate cardiac ryanodine receptor 2... [more]

© 2017, the American Society of Anesthesiologists, Inc. Wolters Kluwer Health, Inc. All Rights Reserved. Background: Halogenated anesthetics activate cardiac ryanodine receptor 2-mediated sarcoplasmic reticulum Ca 2+ release, leading to sarcoplasmic reticulum Ca 2+ depletion, reduced cardiac function, and providing cell protection against ischemia-reperfusion injury. Anesthetic activation of ryanodine receptor 2 is poorly defined, leaving aspects of the protective mechanism uncertain. Methods: Ryanodine receptor 2 from the sheep heart was incorporated into artificial lipid bilayers, and their gating properties were measured in response to five halogenated anesthetics. Results: Each anesthetic rapidly and reversibly activated ryanodine receptor 2, but only from the cytoplasmic side. Relative activation levels were as follows: halothane (approximately 4-fold; n = 8), desflurane and enflurane (approximately 3-fold,n = 9), and isoflurane and sevoflurane (approximately 1.5-fold, n = 7, 10). Half-activating concentrations (K a) were in the range 1.3 to 2.1 mM (1.4 to 2.6 minimum alveolar concentration [MAC]) with the exception of isoflurane (5.3 mM, 6.6 minimum alveolar concentration). Dantrolene (10 µM with 100 nM calmodulin) inhibited ryanodine receptor 2 by 40% but did not alter the K a for halothane activation. Halothane potentiated luminal and cytoplasmic Ca 2+ activation of ryanodine receptor 2 but had no effect on Mg 2+ inhibition. Halothane activated ryanodine receptor 2 in the absence and presence (2 mM) of adenosine triphosphate (ATP). Adenosine, a competitive antagonist to ATP activation of ryanodine receptor 2, did not antagonize halothane activation in the absence of ATP. Conclusions: At clinical concentrations (1 MAC), halothane desflurane and enflurane activated ryanodine receptor 2, whereas isoflurane and sevoflurane were ineffective. Dantrolene inhibition of ryanodine receptor 2 substantially negated the activating effects of anesthetics. Halothane acted independently of the adenine nucleotide-binding site on ryanodine receptor 2. The previously observed adenosine antagonism of halothane activation of sarcoplasmic reticulum Ca 2+ release was due to competition between adenosine and ATP, rather than between halothane and ATP.

DOI 10.1097/ALN.0000000000001519
Citations Scopus - 1Web of Science - 1
Co-authors Tony Quail, Derek Laver, Christopher Oldmeadow
2017 Kable A, Pond D, Hullick C, Chenoweth L, Duggan A, Attia J, Oldmeadow C, 'An evaluation of discharge documentation for people with dementia discharged home from hospital - A cross-sectional pilot study.', Dementia (London), 1471301217728845 (2017)
DOI 10.1177/1471301217728845
Co-authors Dimity Pond, Ashley Kable, Christopher Oldmeadow
2017 Abdullah N, Abdul Murad NA, Mohd Haniff EA, Syafruddin SE, Attia J, Oldmeadow C, et al., 'Predicting type 2 diabetes using genetic and environmental risk factors in a multi-ethnic Malaysian cohort.', Public Health, 149 31-38 (2017)
DOI 10.1016/j.puhe.2017.04.003
Co-authors Rodney Scott, Liz Holliday, Christopher Oldmeadow
2017 Muenchhoff J, Song F, Poljak A, Crawford JD, Mather KA, Kochan NA, et al., 'Plasma apolipoproteins and physical and cognitive health in very old individuals.', Neurobiol Aging, 55 49-60 (2017)
DOI 10.1016/j.neurobiolaging.2017.02.017
Citations Web of Science - 1
Co-authors Mark Mcevoy, Peter Schofield
2017 Siribumrungwong B, Chantip A, Noorit P, Wilasrusmee C, Ungpinitpong W, Chotiya P, et al., 'Comparison of Superficial Surgical Site Infection Between Delayed Primary Versus Primary Wound Closure in Complicated Appendicitis: A Randomized Controlled Trial.', Ann Surg, (2017)
DOI 10.1097/SLA.0000000000002464
Co-authors Mark Mcevoy
2017 Gupta SK, Trethewey S, Brooker B, Rutherford N, Diffey J, Viswanathan S, Attia J, 'Radionuclide bone scan SPECT-CT: lowering the dose of CT significantly reduces radiation dose without impacting CT image quality', AMERICAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 7 63-73 (2017)
2017 Al-Omary MS, Davies AJ, Khan AA, McGee M, Bastian B, Leitch J, et al., 'Heart Failure Hospitalisations in the Hunter New England Area Over 10 years. A Changing Trend', Heart Lung and Circulation, 26 627-630 (2017)

© 2016 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ) Background Heart failure carries... [more]

© 2016 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ) Background Heart failure carries a major burden on our health system, mainly related to the high rate of hospital admission. An understanding of the recent trends in heart failure hospitalisation is essential to the future allocation of health resources. Our aim is to analyse the temporal trends in heart failure hospitalisation. Methods We extracted all separations in the Hunter New England Local Health District between 2005¿2014 (n=40,119) with an ICD 10 code for heart failure (I-50) in the first four diagnoses on discharge. The numbers of hospitalisations were age-standardised to the 2001 Australian population and compared based on gender and remoteness. Results There was a decline in the age-standardised hospitalisation. However, there was a clear inflection point between 2009¿2010, after which the decline levelled off. The absolute number of hospitalisations increased between 2010 and 2014. Heart failure hospitalisation was higher in males compared to females and rural compared to metropolitan inhabitants. Conclusion The gains in heart failure treatment noted in recent years seem to have come to an end. Patients aged 75 years and older are contributing the majority of age-standardised hospitalisations.

DOI 10.1016/j.hlc.2016.10.005
Co-authors Andrew Boyle
2017 Bhaskar S, Bivard A, Stanwell P, Parsons M, Attia JR, Nilsson M, Levi C, 'Baseline collateral status and infarct topography in post-ischaemic perilesional hyperperfusion: An arterial spin labelling study', Journal of Cerebral Blood Flow and Metabolism, 37 1148-1162 (2017) [C1]

© The Author(s) 2016. Focal hyperperfusion after acute ischaemic stroke could be of prognostic value depending upon its spatial localisation and temporal dynamics. Factors associ... [more]

© The Author(s) 2016. Focal hyperperfusion after acute ischaemic stroke could be of prognostic value depending upon its spatial localisation and temporal dynamics. Factors associated with late stage (12-24 h) perilesional hyperperfusion, identified using arterial spin labelling, are poorly defined. A prospective cohort of acute ischaemic stroke patients presenting within 4.5 h of symptom onset were assessed with multi-modal computed tomography acutely and magnetic resonance imaging at 24 ± 8 h. Multivariate logistic regression analysis and receiver operating characteristics curves were used. One hundred and nineteen hemispheric acute ischaemic stroke patients (mean age = 71 ± 12 years) with 24 h arterial spin labelling imaging were included. Forty-Two (35.3%) patients showed perilesional hyperperfusion on arterial spin labelling at 24 h. Several factors were independently associated with perilesional hyperperfusion: good collaterals (71% versus 29%, P < 0.0001; OR = 5, 95% CI = [1.6, 15.7], P = 0.005), major reperfusion (81% versus 48%, P = < 0.0001; OR = 7.5, 95% CI = [1.6, 35.1], P = 0.01), penumbral salvage (76.2% versus 47%, P = 0.002; OR = 6.6, 95% CI = [1.8, 24.5] , P = 0.004), infarction in striatocapsular (OR = 9.5, 95% CI = [2.6, 34], P = 0.001) and in cortical superior division middle cerebral artery (OR = 4.7, 95% CI = [1.4, 15.7] , P = 0.012) territory. The area under the receiver operating characteristic curve was 0.91. Our results demonstrate good arterial collaterals, major reperfusion, penumbral salvage, and infarct topographies involving cortical superior middle cerebral artery and striatocapsular are associated with perilesional hyperperfusion.

DOI 10.1177/0271678X16653133
Citations Scopus - 2Web of Science - 1
Co-authors Michael Nilsson, Mark Parsons, Andrew Bivard, Peter Stanwell, Christopher Levi
2017 Reeves AJ, McEvoy MA, MacDonald-Wicks LK, Barker D, Attia J, Hodge AM, Patterson AJ, 'Calculation of Haem Iron Intake and Its Role in the Development of Iron Deficiency in Young Women from the Australian Longitudinal Study on Women's Health', NUTRIENTS, 9 (2017) [C1]
DOI 10.3390/nu9050515
Co-authors Mark Mcevoy, Amanda Patterson, Lesley Wicks
2017 Scott IA, Attia J, 'Cautionary tales in the interpretation of observational studies of effects of clinical interventions', Internal Medicine Journal, 47 144-157 (2017) [C1]

© 2016 Royal Australasian College of Physicians Observational studies of the effectiveness of clinical interventions are proliferating as more ¿real-world¿ clinical data (so ca... [more]

© 2016 Royal Australasian College of Physicians Observational studies of the effectiveness of clinical interventions are proliferating as more ¿real-world¿ clinical data (so called ¿big data¿) are gathered from clinical registries, administrative datasets and electronic health records. While well-conducted randomised controlled trials (RCT) remain the scientific standard in assessing the efficacy of clinical interventions, well-designed observational studies may add to the evidence base of effectiveness in situations where RCT are of limited value or very difficult to perform. Rather than di smissing observational studies, we need to determine what circumstances may justify doing an observational study and when the study is sufficiently rigorous to be considered reasonably trustworthy. This article proposes criteria by which users of the literature might make such determinations.

DOI 10.1111/imj.13167
Citations Scopus - 2Web of Science - 1
2017 Sharpley CF, Hussain R, Wark SG, Bitsika V, McEvoy MA, Attia JR, 'Prevalence of depressed mood versus anhedonia in older persons: implications for clinical practice', ASIA PACIFIC JOURNAL OF COUNSELLING AND PSYCHOTHERAPY, 8 3-14 (2017)
DOI 10.1080/21507686.2016.1249382
Co-authors Mark Mcevoy
2016 Islam MR, Attia J, Ali L, McEvoy M, Selim S, Sibbritt D, et al., 'Zinc supplementation for improving glucose handling in pre-diabetes: A double blind randomized placebo controlled pilot study', Diabetes Research and Clinical Practice, 115 39-46 (2016) [C1]

© 2016 Elsevier Ireland Ltd. Aims: There are a number of studies showing that zinc supplementation may improve glucose handling in people with established diabetes. We sought to ... [more]

© 2016 Elsevier Ireland Ltd. Aims: There are a number of studies showing that zinc supplementation may improve glucose handling in people with established diabetes. We sought to investigate whether this zinc-dependent improvement in glucose handling could potentially be harnessed to prevent the progression of pre-diabetes to diabetes. In this double-blind randomized placebo-controlled trial, we determined participants' fasting blood glucose levels, (FBG) and Homeostasis Model Assessment (HOMA) parameters (beta cell function, insulin sensitivity and insulin resistance) at baseline and after 6 months of zinc supplementation. Methods: The Bangladesh Institute of Health Sciences Hospital (BIHS) (Mirpur, Dhaka, Bangladesh) database was used to identify 224 patients with prediabetes, of whom 55 met the inclusion criteria and agreed to participate. The participants were randomized either to the intervention or control group using block randomization. The groups received either 30 mg zinc sulphate dispersible tablet or placebo, once daily for six months. Results: After six months, the intervention group significantly improved their FBG concentration compared to the placebo group (5.37 ± 0.20 mmol/L vs 5.69 ± 0.26, p < 0.001) as well as compared to their own baseline (5.37 ± 0.20 mmol/L vs 5.8 ± 0.09, p < 0.001). Beta cell function, insulin sensitivity and insulin resistance all showed a statistically significant improvement as well. Conclusion: To our knowledge this is the first trial to show an improvement in glucose handling using HOMA parameters in participants with prediabetes. Larger randomized controlled trials are warranted to confirm these findings and to explore clinical endpoints.

DOI 10.1016/j.diabres.2016.03.010
Citations Scopus - 2Web of Science - 2
Co-authors Milton Hasnat, Roseanne Peel, Mark Mcevoy
2016 Rosand J, Mitchell BD, Ay H, de Bakker PIW, Gwinn K, Kittner SJ, et al., 'Loci associated with ischaemic stroke and its subtypes (SiGN): A genome-wide association study', The Lancet Neurology, 15 174-184 (2016) [C1]

© 2016 Elsevier Ltd. Background: The discovery of disease-associated loci through genome-wide association studies (GWAS) is the leading genetic approach to the identification of ... [more]

© 2016 Elsevier Ltd. Background: The discovery of disease-associated loci through genome-wide association studies (GWAS) is the leading genetic approach to the identification of novel biological pathways underlying diseases in humans. Until recently, GWAS in ischaemic stroke have been limited by small sample sizes and have yielded few loci associated with ischaemic stroke. We did a large-scale GWAS to identify additional susceptibility genes for stroke and its subtypes. Methods: To identify genetic loci associated with ischaemic stroke, we did a two-stage GWAS. In the first stage, we included 16 851 cases with state-of-the-art phenotyping data and 32 473 stroke-free controls. Cases were aged 16 to 104 years, recruited between 1989 and 2012, and subtypes of ischaemic stroke were recorded by centrally trained and certified investigators who used the web-based protocol, Causative Classification of Stroke (CCS). We constructed case-control strata by identifying samples that were genotyped on nearly identical arrays and were of similar genetic ancestral background. We cleaned and imputed data by use of dense imputation reference panels generated from whole-genome sequence data. We did genome-wide testing to identify stroke-associated loci within each stratum for each available phenotype, and we combined summary-level results using inverse variance-weighted fixed-effects meta-analysis. In the second stage, we did in-silico lookups of 1372 single nucleotide polymorphisms identified from the first stage GWAS in 20 941 cases and 364 736 unique stroke-free controls. The ischaemic stroke subtypes of these cases had previously been established with the Trial of Org 10 172 in Acute Stroke Treatment (TOAST) classification system, in accordance with local standards. Results from the two stages were then jointly analysed in a final meta-analysis. Findings: We identified a novel locus (G allele at rs12122341) at 1p13.2 near TSPAN2 that was associated with large artery atherosclerosis-related stroke (first stage odds ratio [OR] 1·21, 95% CI 1·13-1·30, p=4·50 × 10 -8 ; joint OR 1·19, 1·12-1·26, p=1·30 × 10 -9 ). Our results also supported robust associations with ischaemic stroke for four other loci that have been reported in previous studies, including PITX2 (first stage OR 1·39, 1·29-1·49, p=3·26 × 10 -19 ; joint OR 1·37, 1·30-1·45, p=2·79 × 10 -32 ) and ZFHX3 (first stage OR 1·19, 1·11-1·27, p=2·93 × 10 -7 ; joint OR 1·17, 1·11-1·23, p=2·29 × 10 -10 ) for cardioembolic stroke, and HDAC9 (first stage OR 1·29, 1·18-1·42, p=3·50 × 10 -8 ; joint OR 1·24, 1·15-1·33, p=4·52 × 10 -9 ) for large artery atherosclerosis stroke. The 12q24 locus near ALDH2, which has previously been associated with all ischaemic stroke but not with any specific subtype, exceeded genome-wide significance in the meta-analysis of small artery stroke (first stage OR 1·20, 1·12-1·28, p=6·82 × 10 -8 ; joint OR 1·17, 1·11-1·23, p=2·92 × 10 -9 ). Other loci associated with stroke in previous studies, including NINJ2, were not confirmed. Interpretation: Our results suggest that all ischaemic stroke-related loci previously implicated by GWAS are subtype specific. We identified a novel gene associated with large artery atherosclerosis stroke susceptibility. Follow-up studies will be necessary to establish whether the locus near TSPAN2 can be a target for a novel therapeutic approach to stroke prevention. In view of the subtype-specificity of the associations detected, the rich phenotyping data available in the Stroke Genetics Network (SiGN) are likely to be crucial for further genetic discoveries related to ischaemic stroke. Funding: US National Institute of Neurological Disorders and Stroke, National Institutes of Health.

DOI 10.1016/S1474-4422(15)00338-5
Citations Scopus - 19
Co-authors Christopher Levi, Liz Holliday
2016 Attia JR, Jones MP, 'Introducing an accessible series on statistics for clinicians', MEDICAL JOURNAL OF AUSTRALIA, 205 392-+ (2016)
DOI 10.5694/mja16.00981
Citations Web of Science - 1
2016 Chen MM, O'Mara TA, Thompson DJ, Painter JN, Attia J, Black A, et al., 'GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer', HUMAN MOLECULAR GENETICS, 25 2612-2620 (2016) [C1]
DOI 10.1093/hmg/ddw092
Citations Web of Science - 1
Co-authors Rodney Scott, Liz Holliday, Mark Mcevoy
2016 Painter JN, O'Mara TA, Marquart L, Webb PM, Attia J, Medland SE, et al., 'Genetic risk score mendelian randomization shows that obesity measured as body mass index, but not waist:hip ratio, is causal for endometrial cancer', Cancer Epidemiology Biomarkers and Prevention, 25 1503-1510 (2016) [C1]

Background: The strongest known risk factor for endometrial cancer is obesity. To determine whether SNPs associated with increased body mass index (BMI) or waist-hip ratio (WHR) a... [more]

Background: The strongest known risk factor for endometrial cancer is obesity. To determine whether SNPs associated with increased body mass index (BMI) or waist-hip ratio (WHR) are associated with endometrial cancer risk, independent of measured BMI, we investigated relationships between 77 BMI and 47 WHR SNPs and endometrial cancer in 6,609 cases and 37,926 country-matched controls. Methods: Logistic regression analysis and fixed effects metaanalysis were used to test for associations between endometrial cancer risk and (i) individual BMI orWHRSNPs, (ii) a combined weighted genetic risk score (wGRS) for BMI or WHR. Causality of BMI for endometrial cancer was assessed using Mendelian randomization, with BMIwGRS as instrumental variable. Results: The BMIwGRS was significantly associated with endometrial cancer risk (P -= 3.4 × 10-17). Scaling the effect of the BMIwGRS on endometrial cancer risk by its effect on BMI, the endometrial cancer OR per 5 kg/m2 of genetically predicted BMI was 2.06 [95% confidence interval (CI), 1.89-2.21], larger than the observed effect of BMI on endometrial cancer risk (OR-=1.55; 95% CI, 1.44-1.68, per 5 kg/m2). The association attenuated but remained significant after adjusting for BMI (OR -= 1.22; 95% CI, 1.10-1.39; P -= 5.3 × 10-4). There was evidence of directional pleiotropy (P -= 1.5 × 10-4). BMI SNP rs2075650 was associated with endometrial cancer at study-wide significance (P < 4.0 × 10-4), independent of BMI. Endometrial cancer was not significantly associated with individual WHR SNPs or the WHRwGRS. Conclusions: BMI, but not WHR, is causally associated with endometrial cancer risk, with evidence that some BMI-associated SNPs alter endometrial cancer risk via mechanisms other than measurable BMI. Impact: The causal association between BMI SNPs and endometrial cancer has possible implications for endometrial cancer risk modeling.

DOI 10.1158/1055-9965.EPI-16-0147
Citations Scopus - 3Web of Science - 4
Co-authors Liz Holliday, Mark Mcevoy, Rodney Scott
2016 Okbay A, Baselmans BML, De Neve JE, Turley P, Nivard MG, Fontana MA, et al., 'Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses', Nature Genetics, 48 624-633 (2016) [C1]

© 2016 Nature America, Inc. Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subj... [more]

© 2016 Nature America, Inc. Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (P = 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

DOI 10.1038/ng.3552
Citations Scopus - 49Web of Science - 50
Co-authors Liz Holliday, Christopher Oldmeadow, Rodney Scott
2016 Cheng THT, Thompson DJ, O'Mara TA, Painter JN, Glubb DM, Flach S, et al., 'Five endometrial cancer risk loci identified through genome-wide association analysis', Nature Genetics, 48 667-674 (2016) [C1]

© 2016 Nature America, Inc. We conducted a meta-analysis of three endometrial cancer genome-wide association studies (GWAS) and two follow-up phases totaling 7,737 endometrial ca... [more]

© 2016 Nature America, Inc. We conducted a meta-analysis of three endometrial cancer genome-wide association studies (GWAS) and two follow-up phases totaling 7,737 endometrial cancer cases and 37,144 controls of European ancestry. Genome-wide imputation and meta-analysis identified five new risk loci of genome-wide significance at likely regulatory regions on chromosomes 13q22.1 (rs11841589, near KLF5), 6q22.31 (rs13328298, in LOC643623 and near HEY2 and NCOA7), 8q24.21 (rs4733613, telomeric to MYC), 15q15.1 (rs937213, in EIF2AK4, near BMF) and 14q32.33 (rs2498796, in AKT1, near SIVA1). We also found a second independent 8q24.21 signal (rs17232730). Functional studies of the 13q22.1 locus showed that rs9600103 (pairwise r 2 = 0.98 with rs11841589) is located in a region of active chromatin that interacts with the KLF5 promoter region. The rs9600103[T] allele that is protective in endometrial cancer suppressed gene expression in vitro, suggesting that regulation of the expression of KLF5, a gene linked to uterine development, is implicated in tumorigenesis. These findings provide enhanced insight into the genetic and biological basis of endometrial cancer.

DOI 10.1038/ng.3562
Citations Scopus - 8Web of Science - 7
Co-authors Rodney Scott, Mark Mcevoy, Liz Holliday
2016 Gunathilake R, Oldmeadow C, McEvoy M, Inder KJ, Schofield PW, Nair BR, Attia J, 'The Association Between Obesity and Cognitive Function in Older Persons: How Much Is Mediated by Inflammation, Fasting Plasma Glucose, and Hypertriglyceridemia?', J Gerontol A Biol Sci Med Sci, 71 1603-1608 (2016) [C1]
DOI 10.1093/gerona/glw070
Citations Scopus - 2
Co-authors Mark Mcevoy, Christopher Oldmeadow, Kerry Inder, Peter Schofield
2016 Sridharan S, Steigler A, Spry NA, Joseph D, Lamb DS, Matthews JH, et al., 'Oligometastatic bone disease in prostate cancer patients treated on the TROG 03.04 RADAR trial', Radiotherapy and Oncology, 121 98-102 (2016) [C1]

© 2016 Elsevier Ireland Ltd Background It remains unclear whether eradication of oligometastases by stereotactic body radiation therapy or other means will result in cure or prol... [more]

© 2016 Elsevier Ireland Ltd Background It remains unclear whether eradication of oligometastases by stereotactic body radiation therapy or other means will result in cure or prolongation of survival in some cases, or merely provide palliation. We address this issue with prospectively collected progression and treatment data from the TROG 03.04 RADAR randomised controlled trial for men with locally advanced prostate cancer (PC). Methods Three Fine and Gray competing risk survival models with time-dependent covariates were used to determine whether metastatic progression status at first diagnosis of bony metastases, i.e. number of bony sites involved and presence of prior or simultaneous other sites of progression, impacts on prostate cancer-specific mortality (PCSM) when adjusted for baseline prognostic factors and allocated primary treatment. Results Between 2003 and 2014, 176 of the 1071 subjects developed bone metastases, 152 developed other sites of progression and 91 died of PC. All subjects received secondary treatment using androgen suppression but none received extirpative treatments. The three models found evidence: 1 ¿ of a clear prognostic gradient according to number of bony metastatic sites; 2 ¿ that other sites of progression contributed to PCSM to a lesser extent than bone progression; and 3 ¿ that further bony metastatic progression in men with up to 3 bony metastases had a major impact on PCSM. Conclusion Randomised trials are essential to determine the value of extirpative treatment for oligometastatic bony metastases due to PC.

DOI 10.1016/j.radonc.2016.07.021
Citations Scopus - 3Web of Science - 3
Co-authors Jim Denham, Allison Steigler, Liz Holliday
2016 De Vries PS, Chasman DI, Sabater-Lleal M, Chen MH, Huffman JE, Steri M, et al., 'A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration', Human Molecular Genetics, 25 358-370 (2016) [C1]

© The Author 2015. Published by Oxford University Press. Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concent... [more]

© The Author 2015. Published by Oxford University Press. Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels.We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ~120 000 participants of European ancestry (95 806 participants with data on the X-chromosome). Approximately 10.7 million single-nucleotide polymorphisms and 1.2 million indelswere examined.We identified 41 genome-wide significant fibrinogen loci; of which, 18were newly identified. Therewere no genome-wide significant signals on the X-chromosome. The lead variants of five significant loci were indels. We further identified six additional independent signals, including three rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.

DOI 10.1093/hmg/ddv454
Citations Scopus - 6Web of Science - 7
Co-authors Christopher Oldmeadow, Liz Holliday, Rodney Scott, Mark Mcevoy
2016 Handley TE, Kay-Lambkin FJ, Baker AL, Lewin TJ, Kelly BJ, Inder KJ, et al., 'Investigation of a Suicide Ideation Risk Profile in People with Co-occurring Depression and Substance Use Disorder', Journal of Nervous and Mental Disease, 204 820-826 (2016) [C1]

© Wolters Kluwer Health, Inc. All rights reserved. Disengagement from services is common before suicide, hence identifying factors at treatment presentation that predict future s... [more]

© Wolters Kluwer Health, Inc. All rights reserved. Disengagement from services is common before suicide, hence identifying factors at treatment presentation that predict future suicidality is important. This article explores risk profiles for suicidal ideation among treatment seekers with depression and substance misuse. Participants completed assessments at baseline and 6 months. Baseline demographics, psychiatric history, and current symptoms were entered into a decision tree to predict suicidal ideation at follow-up. Sixty-three percent of participants at baseline and 43.5% at follow-up reported suicidal ideation. Baseline ideation most salient when psychiatric illness began before adulthood, increasing the rate of follow-up ideation by 16%. Among those without baseline ideation, dysfunctional attitudes were the most important risk factor, increasing rates of suicidal ideation by 35%. These findings provide evidence of factors beyond initial diagnoses that increase the likelihood of suicidal ideation and are worthy of clinical attention. In particular, providing suicide prevention resources to those with high dysfunctional attitudes may be beneficial.

DOI 10.1097/NMD.0000000000000473
Citations Scopus - 2Web of Science - 1
Co-authors Amanda Baker, Brian Kelly, Frances Kaylambkin, Kerry Inder, Terry Lewin
2016 Bhaskar S, Bivard A, Stanwell P, Attia JR, Parsons M, Nilsson M, Levi C, 'Association of Cortical Vein Filling with Clot Location and Clinical Outcomes in Acute Ischaemic Stroke Patients', SCIENTIFIC REPORTS, 6 (2016) [C1]
DOI 10.1038/srep38525
Co-authors Michael Nilsson, Andrew Bivard, Christopher Levi, Peter Stanwell, Mark Parsons
2016 Anothaisintawee T, Udomsubpayakul U, McEvoy M, Lerdsitthichai P, Attia J, Thakkinstian A, 'Effect of Lipophilic and Hydrophilic Statins on Breast Cancer Risk in Thai Women: A Cross-sectional Study.', Journal of Cancer, 7 1163-1168 (2016) [C1]
DOI 10.7150/jca.14941
Citations Scopus - 1
Co-authors Mark Mcevoy
2016 Angkananard T, Anothaisintawee T, Eursiriwan S, Gorelik O, McEvoy M, Attia J, Thakkinstian A, 'The association of serum magnesium and mortality outcomes in heart failure patients: A systematic review and meta-analysis.', Medicine (Baltimore), 95 e5406 (2016) [C1]
DOI 10.1097/MD.0000000000005406
Citations Scopus - 1Web of Science - 1
Co-authors Mark Mcevoy
2016 Korda RJ, Soga K, Joshy G, Calabria B, Attia J, Wong D, Banks E, 'Socioeconomic variation in incidence of primary and secondary major cardiovascular disease events: an Australian population-based prospective cohort study', International Journal for Equity in Health, 15 1-10 (2016) [C1]

© 2016 The Author(s). Background: Cardiovascular disease (CVD) disproportionately affects disadvantaged people, but reliable quantitative evidence on socioeconomic variation in C... [more]

© 2016 The Author(s). Background: Cardiovascular disease (CVD) disproportionately affects disadvantaged people, but reliable quantitative evidence on socioeconomic variation in CVD incidence in Australia is lacking. This study aimed to quantify socioeconomic variation in rates of primary and secondary CVD events in mid-age and older Australians. Methods: Baseline data (2006-2009) from the 45 and Up Study, an Australian cohort involving 267,153 men and women aged = 45, were linked to hospital and death data (to December 2013). Outcomes comprised first event - death or hospital admission - for major CVD combined, as well as myocardial infarction and stroke, in those with and without prior CVD (secondary and primary events, respectively). Cox regression estimated hazard ratios (HRs) for each outcome in relation to education (and income and area-level disadvantage), separately by age group (45-64, 65-79, and = 80 years), adjusting for age and sex, and additional sociodemographic factors. Results: There were 18,207 primary major CVD events over 1,144,845 years of follow-up (15.9/1000 person-years), and 20,048 secondary events over 260,357 years (77.0/1000 person-years). For both primary and secondary events, incidence increased with decreasing education, with the absolute difference between education groups largest for secondary events. Age-sex adjusted hazard ratios were highest in the 45-64 years group: for major CVDs, HR (no qualifications vs university degree) = 1.62 (95% CI: 1.49-1.77) for primary events, and HR = 1.49 (1.34-1.65) for secondary events; myocardial infarction HR = 2.31 (1.87-2.85) and HR = 2.57 (1.90-3.47) respectively; stroke HR = 1.48 (1.16-1.87) and HR = 1.97 (1.42-2.74) respectively. Similar but attenuated results were seen in older age groups, and with income. For area-level disadvantage, CVD gradients were weak and non-significant in older people ( > 64 years). Conclusions: Individual-level data are important for quantifying socioeconomic variation in CVD incidence, which is shown to be substantial among both those with and without prior CVD. Findings reinforce the opportunity for, and importance of, primary and secondary prevention and treatment in reducing socioeconomic variation in CVD and consequently the overall burden of CVD morbidity and mortality in Australia.

DOI 10.1186/s12939-016-0471-0
Citations Scopus - 1Web of Science - 2
2016 Faulkner S, Roselli S, Demont Y, Pundavela J, Choquet G, Leissner P, et al., 'ProNGF is a potential diagnostic biomarker for thyroid cancer', Oncotarget, 7 28488-28497 (2016) [C1]

The precursor for nerve growth factor (proNGF) is expressed in some cancers but its clinicopathological significance is unclear. The present study aimed to define the clinicopatho... [more]

The precursor for nerve growth factor (proNGF) is expressed in some cancers but its clinicopathological significance is unclear. The present study aimed to define the clinicopathological significance of proNGF in thyroid cancer. ProNGF expression was analysed by immunohistochemistry in two cohorts of cancer versus benign tumors (adenoma) and normal thyroid tissues. In the first cohort (40 thyroid cancers, 40 thyroid adenomas and 80 normal thyroid tissues), proNGF was found overexpressed in cancers compared to adenomas and normal samples (p < 0.0001). The area under the receiver-operating characteristic (ROC) curve was 0.84 (95% CI 0.75-0.93, p < 0.0001) for cancers versus adenomas, and 0.99 (95% CI 0.98-1.00, p < 0.0001) for cancers versus normal tissues. ProNGF overexpression was confirmed in a second cohort (127 cancers of various histological types and 55 normal thyroid tissues) and using a different antibody (p < 0.0001). ProNGF staining intensity was highest in papillary carcinomas compared to other histological types (p < 0.0001) and there was no significant association with age, gender, tumor size, stage and lymph node status. In conclusion, proNGF is increased in thyroid cancer and should be considered as a new potential diagnostic biomarker.

DOI 10.18632/oncotarget.8652
Citations Scopus - 2Web of Science - 1
Co-authors Christopher Oldmeadow, Marjorie Walker, Hubert Hondermarck
2016 White J, Magin P, Attia J, Sturm J, McElduff P, Carter G, 'Predictors of health-related quality of life in community-dwelling stroke survivors: A cohort study', Family Practice, 33 382-387 (2016) [C1]

© The Author 2016. Published by Oxford University Press. All rights reserved. Background. Impaired health-related quality of life (HRQoL) post stroke is common, though prevalence... [more]

© The Author 2016. Published by Oxford University Press. All rights reserved. Background. Impaired health-related quality of life (HRQoL) post stroke is common, though prevalence estimates vary considerably. Few longitudinal studies explore post-stroke patterns of HRQoL and factors contributing to their change over time. Accurately identifying HRQoL after stroke is essential to understanding the extent of stroke effects. Objectives. This study aimed to assess change in levels of, and identify independent predictors of, HRQoL over the first 12-months post-stroke. Methods. Design. A prospective cohort study. Setting and participants. Community-dwelling stroke survivors in metropolitan Newcastle, New South Wales (NSW), Australia. Consecutively recruited stroke patients (n = 134) participated in face-to-face interviews at baseline, 3, 6, 9 and 12 months. Outcome measure. HRQoL (measured using the Assessment Quality-of-life).Independent measures. Physical and psycho-social functioning, including depression and anxiety (measured via Hospital Anxiety and Depression Scale), disability (Modified Rankin Scale), social support (Multi-dimensional Scale Perceived Social Support) and community participation (Adelaide Activities Profile).Analyses. A linear mixed model was used to establish the predictors of, change in HRQoL over time. Results. On multivariable analysis, HRQOL did not change significantly with time post-stroke. Higher HRQoL scores were independently associated with higher baseline HRQoL (P = 0.03), younger age (P = 0.006), lower disability (P = 0.003), greater community participation (P = 0.001) and no history of depression (P = 0.03). Conclusion. These results contribute to an understanding of HRQoL in the first year post-stroke. Community participation and stroke-related disability are potentially modifiable risk factors affecting post-stroke HRQoL. Interventions aimed at addressing participation and disability post-stroke should be developed and tested.

DOI 10.1093/fampra/cmw011
Co-authors Patrick Mcelduff, Gregory Carter, Parker Magin
2016 Bhaskar S, Bivard A, Parsons M, Nilsson M, Attia JR, Stanwell P, Levi C, 'Delay of late-venous phase cortical vein filling in acute ischemic stroke patients: Associations with collateral status', Journal of Cerebral Blood Flow and Metabolism, 37 671-682 (2016) [C1]

© The Author(s) 2016. Evaluation of the venous system may be useful in stroke prognostication and patient selection for acute intervention strategies. We report a novel phenomeno... [more]

© The Author(s) 2016. Evaluation of the venous system may be useful in stroke prognostication and patient selection for acute intervention strategies. We report a novel phenomenon, delayed-late venous phase cortical vein filling, observed on dynamic computed tomography angiography obtained using multidetector computed tomography scanner, in acute ischemic stroke patients. The aim of this study was to examine the frequency of delayed-late venous phase cortical vein filling and assess its association to baseline collateral status. Dynamic computed tomography angiography images of acute ischemic stroke patients, being assessed for reperfusion therapy, were prospectively studied. Delayed-late venous phase cortical vein filling was defined by late venous phase opacification of cortical veins despite contrast clearance from contralateral cortical veins on dynamic computed tomography angiography. Time to peak of maximum arterial enhancement was recorded. A total of 117 patients (mean age = 70.6 ± 13.3 years; males = 48%) with hemispheric ischemic stroke who underwent acute dynamic computed tomography angiography were included in the study. Overall, 56 (48%) demonstrated delayed-late venous phase cortical vein filling. Poor collateralization (OR = 13.50; 95% CI = (4.2, 43); p = 0.0001) and longer time to peak of maximum arterial enhancement (OR = 3.2; 95% CI = (1.96, 5.3); p= 0.0001) were positively associated with delayed-late venous phase cortical vein filling. Delayed-late venous phase cortical vein filling was independently associated with poor baseline collateral status (75% vs. 15%, p = 0.0001; OR = 14.38; 95% CI = (4.33, 47.8); p = 0.0001). Delayed-late venous phase cortical vein filling is frequently seen in patients with acute ischemic stroke and is associated with poor baseline collateralization.

DOI 10.1177/0271678X16637611
Citations Scopus - 2Web of Science - 3
Co-authors Andrew Bivard, Michael Nilsson, Christopher Levi, Mark Parsons, Peter Stanwell
2016 Seangleulur A, Vanasbodeekul P, Prapaitrakool S, Worathongchai S, Anothaisintawee T, McEvoy M, et al., 'The efficacy of local infiltration analgesia in the early postoperative period after total knee arthroplasty: A systematic review and meta-analysis', European Journal of Anaesthesiology, 33 816-831 (2016) [C1]

BACKGROUND Local infiltration analgesia (LIA) has emerged as an alternative treatment for postoperative pain after total knee arthroplasty (TKA). Its efficacy remains inconclusive... [more]

BACKGROUND Local infiltration analgesia (LIA) has emerged as an alternative treatment for postoperative pain after total knee arthroplasty (TKA). Its efficacy remains inconclusive with inconsistent results from previous studies and meta-analyses. There is no agreement on which local anaesthetic agent and infiltration technique is most effective and well tolerated. OBJECTIVE The objective was to compare LIA after primary TKA with placebo or no infiltration in terms of early postoperative pain relief, mobilisation, length of hospital stay (LOS) and complications when used as a primary treatment or as an adjunct to regional anaesthesia. The role of injection sites, postoperative injection or infusion and multimodal drug injection with ketorolac were also explored. DESIGN A systematic review and meta-analysis of randomised controlled trials (RCTs). DATA SOURCES A literature search was performed using PubMed and SCOPUS up to September 2015. ELIGIBILITY CRITERIA RCTs comparing LIA with placebo or no infiltration after primary TKA in terms of pain score and opioid consumption at 24 and 48 h, mobilisation, LOS and complications were included. RESULTS In total 38 RCTs were included. LIA groups had lower pain scores, opioid consumption and postoperative nausea and vomiting, higher range of motion at 24 h and shorter LOS than no injection or placebo. After subgroup analysis, intraoperative peri-articular but not intra-articular injection had lower pain score at 24 h than no injection or placebo with the pooled mean difference of pain score at rest of -0.89 [95% CI (-1.40 to -0.38); I2=92.0%]. Continuing with postoperative injection or infusion reduced 24-h pain score with the pooled mean difference at rest of -1.50 [95% CI (-1.92 to -1.08); I2=60.5%] . There was no additional benefit in terms of pain relief during activity, opioid consumption, range of movement or LOS when LIA was used as an adjunct to regional anaesthesia. Four out of 735 patients receiving LIA reported deep knee infection, three of whom had had postoperative catheter placement. CONCLUSION LIA is effective for acute pain management after TKA. Intraoperative peri-articular but not intra-articular injection may be helpful in pain control up to 24 h. The use of postoperative intra-articular catheter placement is still inconclusive. The benefit of LIA as an adjunctive treatment to regional anaesthesia was not demonstrated.

DOI 10.1097/EJA.0000000000000516
Citations Scopus - 4Web of Science - 4
Co-authors Mark Mcevoy
2016 Murphy VE, Jensen ME, Mattes J, Hensley MJ, Giles WB, Peek MJ, et al., 'The Breathing for Life Trial: a randomised controlled trial of fractional exhaled nitric oxide (FENO)-based management of asthma during pregnancy and its impact on perinatal outcomes and infant and childhood respiratory health', BMC PREGNANCY AND CHILDBIRTH, 16 (2016)
DOI 10.1186/s12884-016-0890-3
Citations Scopus - 1Web of Science - 1
Co-authors Peter Gibson, Joerg Mattes, Vanessa Murphy, Michael Hensley, Megan Jensen
2016 Lai JS, Oldmeadow C, Hure AJ, McEvoy M, Byles J, Attia J, 'Longitudinal diet quality is not associated with depressive symptoms in a cohort of middle-aged Australian women', British Journal of Nutrition, 115 842-850 (2016) [C1]

Copyright © The Authors 2016. There is increasing evidence for the role of nutrition in the prevention of depression. This study aims to describe changes in diet quality over 12 ... [more]

Copyright © The Authors 2016. There is increasing evidence for the role of nutrition in the prevention of depression. This study aims to describe changes in diet quality over 12 years among participants in the Australian Longitudinal Study on Women's Health in relation to changes in depressive symptoms. Women born between 1946 and 1951 were followed-up for 12 years (2001-2013). Dietary intake was assessed using the Dietary Questionnaire for Epidemiological Studies (version 2) in 2001, 2007 and every 2-3 years after that until 2013. Diet quality was summarised using the Australian Recommended Food Score (ARFS). Depressive symptoms were measured using the ten-item Centre for Epidemiologic Depression Scale at every 2-3-year intervals during 2001-2013. Linear mixed models were used to examine trends in diet quality and its sub-components. The same model including time-varying covariates was used to examine associations between diet quality and depressive symptoms adjusting for confounders. Sensitivity analyses were carried out using the Mediterranean dietary pattern (MDP) index to assess diet quality. Minimal changes in overall diet quality and its sub-components over 12 years were observed. There was a significant association between baseline diet quality and depression (ß=-0 24, P=0 001), but this was lost when time-varying covariates were added (ß=-0 04, P=0 10). Sensitivity analyses showed similar performance for both ARFS and MDP in predicting depressive symptoms. In conclusion, initial associations seen when using baseline measures of diet quality and depressive symptoms disappear when using methods that handle time-varying covariates, suggesting that previous studies indicating a relationship between diet and depression may have been affected by residual confounding.

DOI 10.1017/S000711451500519X
Citations Scopus - 3Web of Science - 2
Co-authors Julie Byles, Christopher Oldmeadow, Alexis Hure, Mark Mcevoy
2016 Attia JR, Jones MP, Suthers B, 'Aiming for the truth: understanding the difference between validity and precision', MEDICAL JOURNAL OF AUSTRALIA, 205 393-+ (2016) [C1]
DOI 10.5694/mja16.00489
2016 Nakayama A, Major G, Holliday E, Attia J, Bogduk N, 'Evidence of effectiveness of a fracture liaison service to reduce the re-fracture rate', Osteoporosis International, 27 873-879 (2016) [C1]

© 2015, The Author(s). Summary: We assessed the ability of a fracture liaison service (FLS) to directly reduce re-fracture risk. Having a FLS is associated with a ~40¿% reductio... [more]

© 2015, The Author(s). Summary: We assessed the ability of a fracture liaison service (FLS) to directly reduce re-fracture risk. Having a FLS is associated with a ~40¿% reduction in the 3-year risk of major bone and ~30¿% of any bone re-fracture. The number needed to treat to prevent a re-fracture is 20. Introduction: FLS have been promoted as the most effective interventions for secondary fracture prevention, and while there is evidence of increased rate of investigation and treatment at institutions with a FLS, only a few studies have considered fracture outcomes directly. We therefore sought to evaluate the ability of our FLS to reduce re-fracture risk. Methods: Historical cohort study of all patients =50¿years presenting over a 6-month period with¿a minimal trauma fracture (MTF) to the emergency departments of a tertiary hospital with a FLS, and one without a FLS. Baseline characteristics, mortality and MTFs over a 3-year follow-up were recorded. Results: Five hundred fifteen patients at the FLS hospital and 416 patients at the non-FLS hospital were studied. Over 3¿years, 63/515 (12¿%) patients at the FLS hospital and 70/416 (17¿%) at the non-FLS hospital had a MTF. All patients were analysed in an intention-to-treat analysis regardless of whether they were seen in the FLS follow-up clinic. Statistical analysis using Cox proportional hazard models in the presence of a competing risk of death from any cause was used. After adjustment for baseline characteristics, there was a ~30¿% reduction in rate of any re-fracture at the FLS hospital (hazard ratio (HR) 0.67, confidence interval (CI) 0.47-0.95, p value 0.025) and a ~40¿% reduction in major re-fractures (hip, spine, femur, pelvis or humerus) (HR 0.59, CI 0.39-0.90, p value 0.013). Conclusions: We found a ~30¿% reduction in any re-fractures and a ~40¿% reduction in major re-fractures at the FLS hospital compared with a similar non-FLS hospital. The number of patients needed to treat to prevent one new fracture over 3¿years is 20.

DOI 10.1007/s00198-015-3443-0
Citations Scopus - 14Web of Science - 15
Co-authors Liz Holliday, Nik Bogduk
2016 Wattanawong K, Rattanasiri S, McEvoy M, Attia J, Thakkinstian A, 'Association between IRF6 and 8q24 polymorphisms and nonsyndromic cleft lip with or without cleft palate: Systematic review and meta-analysis', Birth Defects Research Part A - Clinical and Molecular Teratology, 106 773-788 (2016) [C1]

© 2016 The Authors Birth Defects Research Part A: Clinical and Molecular Teratology Published by Wiley Periodicals, Inc. Background: We conducted a systematic review and meta-ana... [more]

© 2016 The Authors Birth Defects Research Part A: Clinical and Molecular Teratology Published by Wiley Periodicals, Inc. Background: We conducted a systematic review and meta-analysis of interferon regulatory factor 6 and 8q24 polymorphisms with nonsyndromic cleft lip with/without cleft palate (NSCL/P). Methods: Data extraction was independently performed by two reviewers. Genotypic effects of four polymorphisms from 31 studies were pooled separately by ethnicity using a mixed-effect logit model with accounting for heterogeneity. Results: For rs2235371, AA and GA carried, respectively, 51% (95% confidence interval [CI], 37%¿61%) and 42% (95% CI, 32%¿50%) lower risks of NSCL/P than GG genotypes in Asians, but these genotypes were not significant in Caucasians. For rs2013162, only AA was significant, that is, carried 0.65 (95% CI, 0.52¿0.82) times lower odds than CC in Caucasians but not for Asians. For rs642961, AA and GA genotypes, respectively, carried 2.47 (95% CI, 1.41¿4.35) and 1.40 (95% CI, 1.12¿1.75) times higher odds in Asian, and 2.03 (95% CI, 1.52¿2.71) and 1.58 (95% CI, 1.37¿1.82) times higher odds in Caucasians compare with GG genotypes. For rs987525, AA and CA genotypes carried 2.27 (95% CI, 1.43¿3.60) and 1.34 (95% CI, 1.02¿1.77) times higher odds in Asian, and 5.25 (95% CI, 3.98¿6.91) and 2.13 (95% CI¿1.82, 2.49) times higher odds in Caucasians, and 1.42 (95% CI, 1.10¿1.82) and 1.28 (95% CI, 1.09¿1.50) times higher odds in mixed ethnicities compared with CC genotypes. These variant effects remained significant based on applying Bonferroni corrected-thresholds, except in the mixed ethnicity. Conclusion: We show robust variant effects in NSCL/P. Considering them with other genes and risk factors might be useful to improve prediction of NSCL/P occurrence. Birth Defects Research (Part A) 106:773¿788, 2016. © 2016 The Authors Birth Defects Research Part A: Clinical and Molecular Teratology Published by Wiley Periodicals, Inc.

DOI 10.1002/bdra.23540
Citations Scopus - 3Web of Science - 3
Co-authors Mark Mcevoy
2016 Attia JR, Jones MP, Suthers B, 'Aiming for the truth: understanding the difference between validity and precision', MEDICAL JOURNAL OF AUSTRALIA, 205 393-+ (2016) [C1]
DOI 10.5694/mja16.00489
2016 Ashman AM, Collins CE, Weatherall L, Brown LJ, Rollo ME, Clausen D, et al., 'A cohort of Indigenous Australian women and their children through pregnancy and beyond: The Gomeroi gaaynggal study', Journal of Developmental Origins of Health and Disease, 7 357-368 (2016) [C1]

© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2016. Indigenous Australians have high rates of chronic diseases, the c... [more]

© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2016. Indigenous Australians have high rates of chronic diseases, the causes of which are complex and include social and environmental determinants. Early experiences in utero may also predispose to later-life disease development. The Gomeroi gaaynggal study was established to explore intrauterine origins of renal disease, diabetes and growth in order to inform the development of health programmes for Indigenous Australian women and children. Pregnant women are recruited from antenatal clinics in Tamworth, Newcastle and Walgett, New South Wales, Australia, by Indigenous research assistants. Measures are collected at three time points in pregnancy and from women and their children at up to eight time points in the child's first 5 years. Measures of fetal renal development and function include ultrasound and biochemical biomarkers. Dietary intake, infant feeding and anthropometric measurements are collected. Standardized procedures and validated tools are used where available. Since 2010 the study has recruited over 230 women, and retained 66 postpartum. Recruitment is ongoing, and Gomeroi gaaynggal is currently the largest Indigenous pregnancy-through-early-childhood cohort internationally. Baseline median gestational age was 39.1 weeks (31.5-43.2, n=110), median birth weight was 3180 g (910-5430 g, n=110). Over one third (39.3%) of infants were admitted to special care or neonatal nursery. Nearly half of mothers (47.5%) reported tobacco smoking during pregnancy. Results of the study will contribute to knowledge about origins of chronic disease in Indigenous Australians and nutrition and growth of women and their offspring during pregnancy and postpartum. Study strengths include employment and capacity-building of Indigenous staff and the complementary ArtsHealth programme.

DOI 10.1017/S204017441600009X
Citations Scopus - 1Web of Science - 2
Co-authors Clare Collins, Megan Rollo, Caroline Blackwell, E Lumbers, Kirsty Pringle, Roger Smith, Leanne Brown, Kym Rae
2016 Chen MM, O'Mara TA, Thompson DJ, Painter JN, Attia J, Black A, et al., 'GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer', Human molecular genetics, 25 2612-2620 (2016)

© The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. Endometrial cancer is the most common ... [more]

© The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10 -8) at 6p22.3 (rs1740828; P = 2.29 × 10 -8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.

Citations Scopus - 1
Co-authors Rodney Scott, Liz Holliday, Mark Mcevoy
2016 Johnson NA, Kypri K, Latter J, Attia J, McEvoy M, Dunlop A, Scott R, 'Genetic feedback to reduce alcohol consumption in hospital outpatients with risky drinking: Feasibility and acceptability', Public Health Research and Practice, 26 (2016) [C1]

© 2016 Johnson et al. Objective: There have been no trials in healthcare settings of genetic susceptibility feedback in relation to alcohol consumption. The purpose of this study... [more]

© 2016 Johnson et al. Objective: There have been no trials in healthcare settings of genetic susceptibility feedback in relation to alcohol consumption. The purpose of this study was to determine the feasibility and acceptability of conducting a full-scale randomised trial estimating the effect of personalised genetic susceptibility feedback on alcohol consumption in hospital outpatients with risky drinking. Methods: Outpatients =18 years of age who reported drinking more than 14 standard drinks in the past week or in a typical week were asked to provide a saliva sample for genetic testing. Genetic susceptibility feedback was posted to participants 6 months after recruitment. The co-primary outcomes were the proportion of participants who (i) provided a saliva sample that could be genotyped, and (ii) spoke with a genetic counsellor. Secondary outcomes included changes in patients' weekly alcohol consumption; scores on scales measuring readiness to change, importance of changing and confidence in ability to change drinking habits; knowledge about which cancers are alcohol-attributable; and acceptability of the saliva collection procedure and the genetic-feedback intervention. McNemar's test and paired t-tests were used to test for differences between baseline and follow-up in proportions and means, respectively. Results: Of 100 participants who provided a saliva sample, 93 had adequate DNA for at least one genotyping assay. Three participants spoke to a genetic counsellor. Patients' readiness to change their drinking, their views on the importance of changing and their stated confidence in their ability to change increased between baseline and follow-up. There was no increase in patients' knowledge about alcohol-attributable cancers nor any reduction in how much alcohol they drank 4 months after receiving the feedback. Most participant s (80%) were somewhat comfortable or very comfortable with the process used to collect saliva, 84% understood the genetic feedback, 54% found it useful, 10% had sought support to reduce their drinking after receiving the feedback, and 37% reported that the feedback would affect how much they drink in the future. Conclusion: Results of this study suggest it would be feasible to conduct a methodologically robust trial estimating the effect of genetic susceptibility feedback on alcohol consumption in hospital outpatients with risky drinking.

DOI 10.17061/phrp2641645
Co-authors Kypros Kypri, Natalie Johnson, Joanna Latter, Mark Mcevoy, A Dunlop, Rodney Scott
2016 Lillicrap T, Krishnamurthy V, Attia J, Nilsson M, Levi CR, Parsons MW, Bivard A, 'Modafinil In Debilitating fatigue After Stroke (MIDAS): study protocol for a randomised, double-blinded, placebo-controlled, crossover trial', TRIALS, 17 (2016)
Citations Scopus - 1Web of Science - 1
Co-authors Christopher Levi, Mark Parsons, Andrew Bivard, Michael Nilsson
2016 Sarwar G, Bisquera A, Peel R, Hancock S, Grainge C, Attia J, 'The effect of inhaled corticosteroids on bone mineral density measured by quantitative ultrasonography in an older population', Clinical Respiratory Journal, (2016)

© 2016 John Wiley &amp; Sons Ltd. Introduction: Prolonged use of systemic corticosteroids leads to reduced bone mineral density and osteoporosis, in turn increasing the risk of... [more]

© 2016 John Wiley & Sons Ltd. Introduction: Prolonged use of systemic corticosteroids leads to reduced bone mineral density and osteoporosis, in turn increasing the risk of minimal trauma fractures with their associated morbidity and mortality in elderly populations. However, the effect of inhaled corticosteroids on bone mineral density has been debated in the medical literature. Objectives: We aimed to determine the effect of inhaled corticosteroids on bone mineral density measured using calcaneal quantitative ultrasonography in a cohort of older Australians. Methods: Data was collected from the Hunter Community Study, a longitudinal cohort of Australians aged 55-85. Simple and multiple linear regression methods were used to test the cross-sectional association between inhaled corticosteroids and calcaneal bone mineral density measured with quantitative ultrasound at baseline. A causal diagram was used to determine the minimally sufficient number of co-variates necessary to determine the unconfounded effect of inhaled corticosteroids on bone mineral density; these included gender, body mass index, smoking, asthma, alcohol use, age, physical activity, and diet. Results: There were 152 (6.8%) patients on inhaled corticosteroids and 2098 (93%) controls. Simple and multiple linear regression methods showed a non-significant effect of inhaled steroids on BMD with slight decrease of BMD -0.010 g/cm 2 (95% CI -0.042 to 0.022, P=.55) and -0.013 g/cm 2 (95% CI -0.062 to 0.036, P=.61) respectively. Age, gender, body mass index, and smoking were stronger predictors of BMD. Conclusions: No statistically significant relationship was detected between the use of inhaled corticosteroids and reduced bone mineral density in this observational study of a cohort of older Australians.

DOI 10.1111/crj.12576
Co-authors Roseanne Peel, Christopher Grainge
2016 Bhaskar S, Stanwell P, Bivard A, Spratt N, Walker R, Kitsos GH, et al., 'The influence of initial stroke severity on the likelihood of unfavourable clinical outcome and death at 90 days following acute ischemic stroke: A tertiary hospital stroke register study', Neurology India, In press (2016)
Co-authors Michael Nilsson, Neil Spratt, Andrew Bivard, Peter Stanwell, Christopher Levi, Mark Parsons
2016 Hure A, Oldmeadow C, Attia J, 'Invited Commentary: Improving Estimates of Severe Acute Malnutrition Requires More Data', AMERICAN JOURNAL OF EPIDEMIOLOGY, 184 870-872 (2016)
DOI 10.1093/aje/kww131
Co-authors Christopher Oldmeadow, Alexis Hure
2016 Malik R, Traylor M, Pulit SL, Bevan S, Hopewell JC, Holliday EG, et al., 'Low-frequency and common genetic variation in ischemic stroke The METASTROKE collaboration', NEUROLOGY, 86 1217-1226 (2016) [C1]
DOI 10.1212/WNL.0000000000002528
Citations Scopus - 13Web of Science - 13
Co-authors Liz Holliday, Christopher Levi
2016 Anne S, Tse R, Oldmeadow C, Attia JR, Cala AD, 'Immersion of bovine eyeballs after 1 hour in seawater does not result in elevation of postmortem vitreous humor sodium and chloride levels', American Journal of Forensic Medicine and Pathology, 37 108-111 (2016) [C1]

© Copyright 2016 Wolters Kluwer Health, Inc. Elevations in postmortem vitreous sodium chloride (PMVSC) levels may help in differentiating saltwater/seawater drowning (SWD) deaths... [more]

© Copyright 2016 Wolters Kluwer Health, Inc. Elevations in postmortem vitreous sodium chloride (PMVSC) levels may help in differentiating saltwater/seawater drowning (SWD) deaths from immersion deaths not related to drowning (DNRD). It is unclear whether the elevation is related to blood/plasma electrolyte changes after inhalation of seawater as hypothesized in SWDs or possibly caused by electrolyte diffusion and/or osmosis across the outer coats of the eyeball during immersion. Aim: To investigate the changes in bovine PMVSC levels at different time points while immersed in seawater. Methods: Bovine eyeballs were obtained from an abattoir and randomized into 2 groups: A) submerged in seawater ("wet" group) or b) placed in an impermeable plastic bag that was immersed in seawater ("dry" group). The PMVSC levels from 6 eyeballs were measured from each group (without replacement) at 30 minutes, 1 hour, 6 hours, and 12 hours. Results: There was no significant difference in mean PMVSC levels between the 2 groups at 30-minute and 1-hour intervals. A significant difference was noted from 6 hours onward. Discussion: There is no statistically significant elevation in bovine PMVSC levels when immersed in seawater for up to 1 hour. Assuming similar physical properties in humans, any elevations in PMVSC levels in bodies immersed in seawater for less than 1 hour should not be caused by immersion.

DOI 10.1097/PAF.0000000000000229
Citations Scopus - 1Web of Science - 1
Co-authors Christopher Oldmeadow
2016 Garland J, Tse R, Oldmeadow C, Attia J, Anne S, Cala AD, 'Elevation of post mortem vitreous humour sodium and chloride levels can be used as a reliable test in cases of suspected salt water drowning when the immersion times are less than one hour', Forensic Science International, 266 338-342 (2016) [C1]

© 2016 Background Previous studies in salt water drowning deaths (SWD) demonstrated an observable elevation of post mortem vitreous sodium and chloride (PMVSC) levels. It remains... [more]

© 2016 Background Previous studies in salt water drowning deaths (SWD) demonstrated an observable elevation of post mortem vitreous sodium and chloride (PMVSC) levels. It remains unclear what the underlying mechanism responsible for this change is: whether this is due to rapid electrolyte changes from salt water inhalation/ingestion during drowning or from electrolyte diffusion and/or osmosis across the outer coats of the eyeballs during immersion. A recent animal study using sacrificed bovine eyeballs immersed in salt water demonstrated no significant elevations in PMVSC when immersed for less than one hour. Assuming similar physical properties between human and bovine, we extrapolate that an elevation in PMVSC in SWD with immersion times of less than one hour (SWD-1) would not be from immersion, but from drowning. Aim Investigate whether there is an elevation in PMVSC in SWD-1. Methods Retrospective study comparing PMVSC in SWD-1 with controls from 2012 to 2015 inclusive. Results PMVSC in SWD-1 was significantly elevated compared with controls. A PMVSC of 259¿mmol/L has a sensitivity, specificity and likelihood ratio of 0.9, 0.9 and 7.6, respectively. Conclusion The elevation in PMVSC in SWD-1 is due to drowning. A PMVSC of 259¿mmol/L and above is a reliable ancillary test in diagnosing drowning in bodies immersed in salt water for less than one hour.

DOI 10.1016/j.forsciint.2016.06.001
Citations Scopus - 1Web of Science - 1
Co-authors Christopher Oldmeadow
2016 Bolton KA, Avery-Kiejda KA, Holliday EG, Attia J, Bowden NA, Scott RJ, 'A polymorphic repeat in the IGF1 promoter influences the risk of endometrial cancer', ENDOCRINE CONNECTIONS, 5 115-122 (2016) [C1]
DOI 10.1530/EC-16-0003
Citations Web of Science - 1
Co-authors Kelly Kiejda, Nikola Bowden, Liz Holliday, Rodney Scott
2016 O'Brien KM, Williams A, Wiggers J, Wolfenden L, Yoong S, Campbell E, et al., 'Effectiveness of a healthy lifestyle intervention for low back pain and osteoarthritis of the knee: protocol and statistical analysis plan for two randomised controlled trials', BRAZILIAN JOURNAL OF PHYSICAL THERAPY, 20 477-489 (2016)
DOI 10.1590/bjpt-rbf.2014.0189
Co-authors Luke Wolfenden, Christopher Oldmeadow, Christopher M Williams, Serene Yoong, John Wiggers
2016 Searles A, Doran C, Attia J, Knight D, Wiggers J, Deeming S, et al., 'An approach to measuring and encouraging research translation and research impact', HEALTH RESEARCH POLICY AND SYSTEMS, 14 (2016) [C1]
DOI 10.1186/s12961-016-0131-2
Citations Scopus - 3Web of Science - 4
Co-authors Michael Nilsson, Darryl Knight, John Wiggers, Joerg Mattes
2016 Paul CL, Ryan A, Rose S, Attia JR, Kerr E, Koller C, Levi CR, 'How can we improve stroke thrombolysis rates? A review of health system factors and approaches associated with thrombolysis administration rates in acute stroke care', IMPLEMENTATION SCIENCE, 11 (2016) [C1]
DOI 10.1186/s13012-016-0414-6
Citations Scopus - 2Web of Science - 4
Co-authors Chris Paul, Christopher Levi
2016 Hullick C, Conway J, Higgins I, Hewitt J, Dilworth S, Holliday E, Attia J, 'Emergency department transfers and hospital admissions from residential aged care facilities: a controlled pre-post design study.', BMC geriatrics, 16 102 (2016) [C1]
DOI 10.1186/s12877-016-0279-1
Citations Scopus - 2Web of Science - 2
Co-authors Isabel Higgins, Liz Holliday
2016 Thompson DJ, O'Mara TA, Glubb DM, Painter JN, Cheng T, Folkerd E, et al., 'CYP19A1 fine-mapping and Mendelian randomization: Estradiol is causal for endometrial cancer', Endocrine-Related Cancer, 23 77-91 (2016) [C1]

© 2016 The authors. Candidate gene studies have reported CYP19A1 variants to be associated with endometrial cancerandwith estradiol (E2) concentrations.We analyzed2937singlenucle... [more]

© 2016 The authors. Candidate gene studies have reported CYP19A1 variants to be associated with endometrial cancerandwith estradiol (E2) concentrations.We analyzed2937singlenucleotidepolymorphisms (SNPs) in 6608 endometrial cancer cases and 37 925 controls and report the first genome widesignificant association between endometrial cancer and a CYP19A1 SNP (rs727479 in intron 2, P=4.8×10 -11 ). SNP rs727479 was also among those most strongly associated with circulating E2 concentrations in 2767 post-menopausal controls (P=7.4×10 -8 ). The observed endometrial cancer odds ratio per rs727479 A-allele (1.15, CI=1.11-1.21) is compatible with that predicted by theobservedeffectonE 2 concentrations (1.09, CI=1.03-1.21), consistentwith the hypothesis that endometrial cancer risk is driven by E2. From 28 candidate-causal SNPs, 12 co-located with three putative gene-regulatory elements and their risk alleles associated with higher CYP19A1 expression in bioinformatical analyses. For both phenotypes, the associationswith rs727479 were stronger amongwomen with a higher BMI (PinteractionZ0.034 and 0.066 respectively), suggesting a biologically plausible gene-environment interaction.

DOI 10.1530/ERC-15-0386
Citations Scopus - 7Web of Science - 8
Co-authors Rodney Scott, Liz Holliday, Mark Mcevoy
2016 Paterson MA, Smart CEM, Lopez PE, Mcelduff P, Attia J, Morbey C, King BR, 'Influence of dietary protein on postprandial blood glucose levels in individuals with Type¿1 diabetes mellitus using intensive insulin therapy', Diabetic Medicine, 33 592-598 (2016) [C1]

© 2016 Diabetes UK. Aim: To determine the effects of protein alone (independent of fat and carbohydrate) on postprandial glycaemia in individuals with Type¿1 diabetes mellitus u... [more]

© 2016 Diabetes UK. Aim: To determine the effects of protein alone (independent of fat and carbohydrate) on postprandial glycaemia in individuals with Type¿1 diabetes mellitus using intensive insulin therapy. Methods: Participants with Type¿1 diabetes mellitus aged 7-40¿years consumed six 150¿ml whey isolate protein drinks [0¿g (control), 12.5, 25, 50, 75 and 100] and two 150¿ml glucose drinks (10 and 20¿g) without insulin, in randomized order over 8¿days, 4¿h after the evening meal. Continuous glucose monitoring was used to assess postprandial glycaemia. Results: Data were collected from 27 participants. Protein loads of 12.5 and 50¿g did not result in significant postprandial glycaemic excursions compared with control (water) throughout the 300¿min study period (P¿ > ¿0.05). Protein loads of 75 and 100¿g resulted in lower glycaemic excursions than control in the 60-120¿min postprandial interval, but higher excursions in the 180-300¿min interval. In comparison with 20¿g glucose, the large protein loads resulted in significantly delayed and sustained glucose excursions, commencing at 180¿min and continuing to 5¿h. Conclusions: Seventy-five grams or more of protein alone significantly increases postprandial glycaemia from 3 to 5¿h in people with Type¿1 diabetes mellitus using intensive insulin therapy. The glycaemic profiles resulting from high protein loads differ significantly from the excursion from glucose in terms of time to peak glucose and duration of the glycaemic excursion. This research supports recommendations for insulin dosing for large amounts of protein.

DOI 10.1111/dme.13011
Citations Scopus - 3Web of Science - 3
Co-authors Patrick Mcelduff, Bruce King
2016 Ren S, Hure A, Peel R, D'Este C, Abhayaratna W, Tonkin A, et al., 'Rationale and design of a randomized controlled trial of pneumococcal polysaccharide vaccine for prevention of cardiovascular events: The Australian Study for the Prevention through Immunization of Cardiovascular Events (AUSPICE)', AMERICAN HEART JOURNAL, 177 58-65 (2016)
DOI 10.1016/j.ahj.2016.04.003
Citations Scopus - 1Web of Science - 1
Co-authors D Durrheim, Catherine Deste, Roseanne Peel, David Newby, Alexis Hure, Philip Hansbro, Mark Mcevoy, Christopher Levi
2016 Lai JS, Oldmeadow C, Hure AJ, McEvoy M, Hiles SA, Boyle M, Attia J, 'Inflammation mediates the association between fatty acid intake and depression in older men and women', Nutrition Research, 36 234-245 (2016) [C1]

© 2016 Elsevier Inc. Antioxidants and fatty acids are associated with depression and inflammation, and inflammation appears to predict depression risk; hence, the associations be... [more]

© 2016 Elsevier Inc. Antioxidants and fatty acids are associated with depression and inflammation, and inflammation appears to predict depression risk; hence, the associations between these nutrients and depression may be mediated by inflammation. We hypothesized that inflammatory markers interleukin (IL)-6 and C-reactive protein (CRP) mediate the associations between antioxidant and fatty acid intakes, and depression. Participants were from the Hunter Community Study, a longitudinal cohort of adults aged 55-85 years. Dietary intake was assessed using the Older Australian's Food Frequency Questionnaire. Fasting blood samples were drawn for analysis of nutrient and inflammatory biomarkers. Depressive symptoms were assessed using the 20-item Center for Epidemiologic Studies-Depression scale at baseline and at 5-year follow-up. Linear mixed models were used to investigate longitudinal associations between dietary intakes and depression, and mediation analyses were carried out to determine if IL-6 and/or CRP were the mediators. Analyses were conducted on men and women separately and adjusted for potential confounders. Fruit and monounsaturated fat intakes were negatively associated with depression, whereas total fat and saturated fat intakes were positively associated with depression in both sexes. Omega-3 polyunsaturated fat was inversely associated with depression in men only. IL-6 was a significant mediator of the association between fruits with low carotenoid content and depression in women. CRP significantly mediated the relationship between total fat, saturated fat, and monounsaturated fat intakes and depression in women, and saturated fat intake and depression in men. Our findings raise the possibility that the association between fatty acid intake and depression is partially mediated by inflammatory markers.

DOI 10.1016/j.nutres.2015.11.017
Co-authors Mark Mcevoy, Sarah Hiles, Alexis Hure, Christopher Oldmeadow
2016 Ibrahim-Verbaas CA, Bressler J, Debette S, Schuur M, Smith AV, Bis JC, et al., 'GWAS for executive function and processing speed suggests involvement of the CADM2 gene', Molecular Psychiatry, 21 189-197 (2016) [C1]

© 2016 Macmillan Publishers Limited All rights reserved. To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conduct... [more]

© 2016 Macmillan Publishers Limited All rights reserved. To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information processing speed in non-demented older adults from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium. Neuropsychological testing was available for 5429-32 070 subjects of European ancestry aged 45 years or older, free of dementia and clinical stroke at the time of cognitive testing from 20 cohorts in the discovery phase. We analyzed performance on the Trail Making Test parts A and B, the Letter Digit Substitution Test (LDST), the Digit Symbol Substitution Task (DSST), semantic and phonemic fluency tests, and the Stroop Color and Word Test. Replication was sought in 1311-21860 subjects from 20 independent cohorts. A significant association was observed in the discovery cohorts for the single-nucleotide polymorphism (SNP) rs17518584 (discovery P-value=3.12 × 10 -8) and in the joint discovery and replication meta-analysis (P-value=3.28 × 10 -9 after adjustment for age, gender and education) in an intron of the gene cell adhesion molecule 2 (CADM2) for performance on the LDST/DSST. Rs17518584 is located about 170 kb upstream of the transcription start site of the major transcript for the CADM2 gene, but is within an intron of a variant transcript that includes an alternative first exon. The variant is associated with expression of CADM2 in the cingulate cortex (P-value=4 × 10 -4). The protein encoded by CADM2 is involved in glutamate signaling (P-value=7.22 × 10 -15), gamma-aminobutyric acid (GABA) transport (P-value=1.36 × 10 -11) and neuron cell-cell adhesion (P-value=1.48 × 10 -13). Our findings suggest that genetic variation in the CADM2 gene is associated with individual differences in information processing speed.

DOI 10.1038/mp.2015.37
Citations Scopus - 12Web of Science - 9
Co-authors Liz Holliday, Rodney Scott, Peter Schofield, Christopher Oldmeadow
2016 Bolton KA, Holliday EG, Attia J, Bowden NA, Avery-Kiejda KA, Scott RJ, 'A novel polymorphic repeat in the upstream regulatory region of the estrogen-induced gene EIG121 is not associated with the risk of developing breast or endometrial cancer', BMC Research Notes, 9 (2016) [C1]

© 2016 The Author(s). Background: The estrogen-induced gene 121 (EIG121) has been associated with breast and endometrial cancers, but its mechanism of action remains unknown. In ... [more]

© 2016 The Author(s). Background: The estrogen-induced gene 121 (EIG121) has been associated with breast and endometrial cancers, but its mechanism of action remains unknown. In a genome-wide search for tandem repeats, we found that EIG121 contains a short tandem repeat (STR) in its upstream regulatory region which has the potential to alter gene expression. The presence of this STR has not previously been analysed in relation to breast or endometrial cancer risk. Results: In this study, the lengths of this STR were determined by PCR, fragment analysis and sequencing using DNA from 223 breast cancer patients, 204 endometrial cancer patients and 220 healthy controls to determine if they were associated with the risk of developing breast or endometrial cancer. We found this repeat to be highly variable with the number of copies of the AG motif ranging from 27 to 72 and having a bimodal distribution. No statistically significant association was identified between the length of this STR and the risk of developing breast or endometrial cancer or age at diagnosis. Conclusions: The STR in the upstream regulatory region of EIG121 is highly polymorphic, but is not associated with the risk of developing breast or endometrial cancer in the cohorts analysed here. While this polymorphic STR in the regulatory region of EIG121 appears to have no impact on the risk of developing breast or endometrial cancer, its association with disease recurrence or overall survival remains to be determined.

DOI 10.1186/s13104-016-2086-3
Citations Scopus - 1
Co-authors Liz Holliday, Rodney Scott, Kelly Kiejda, Nikola Bowden
2016 Tantrakul V, Numthavaj P, Guilleminault C, McEvoy M, Panburana P, Khaing W, et al., 'Performance of screening questionnaires for obstructive sleep apnea during pregnancy: A systematic review and meta-analysis', Sleep Medicine Reviews, (2016)

© 2016 The Authors. This review aims to evaluate the performance of obstructive sleep apnea (OSA) screening questionnaires during pregnancy. A systematic review and meta-analysis... [more]

© 2016 The Authors. This review aims to evaluate the performance of obstructive sleep apnea (OSA) screening questionnaires during pregnancy. A systematic review and meta-analysis was performed using MEDLINE Scopus, CINAHL, and the Cochrane library. A bivariate meta-analysis was applied for pooling of diagnostic parameters. Six of the total 4719 articles met the inclusion criteria. The Berlin questionnaire (BQ, N = 604) and Epworth sleepiness scale (ESS, N = 420) were the most frequently used screening tools during pregnancy. The pooled prevalence of OSA during pregnancy was 26.7% (95%CI: 16.9%, 34.4%, I 2 = 83.15%). BQ performance was poor to fair with pooled sensitivity and specificity of 0.66 (95%CI: 0.45, 0.83; I 2 = 78.65%) and 0.62 (95%CI: 0.48, 0.75; I 2 = 81.55%), respectively. BQ performance was heterogeneous depending on type of reference test and pregnancy. Sensitivity increased if diagnosis was based on polysomnography (0.90), and respiratory disturbance index (0.90). However, sensitivity decreased if screening was performed in early pregnancy (=20 weeks gestation: 0.47), and high-risk pregnancy (0.44). Performance of ESS was poor with pooled sensitivity and specificity of 0.44 (95%CI: 0.33, 0.56; I 2 = 32.8%) and 0.62 (95%CI: 0.48, 0.75; I 2 = 81.55%), respectively. In conclusion, BQ and ESS showed poor performance during pregnancy, hence a new OSA screening questionnaire is needed.Registration: PROSPERO registration CRD42015025848.

DOI 10.1016/j.smrv.2016.11.003
Co-authors Mark Mcevoy
2016 Kypri K, Wilson A, Attia J, Sheeran P, Miller P, McCambridge J, 'Social desirability bias in the reporting of alcohol consumption: A randomized trial', Journal of Studies on Alcohol and Drugs, 77 526-531 (2016) [C1]

© 2016, Alcohol Research Documentation Inc. All rights reserved. Objective: To investigate reporting of alcohol consumption, we manipulated the contexts of questions in ways desi... [more]

© 2016, Alcohol Research Documentation Inc. All rights reserved. Objective: To investigate reporting of alcohol consumption, we manipulated the contexts of questions in ways designed to induce social desirability bias. Method: We undertook a two-arm, parallel-group, individually randomized trial at an Australian public university. Students were recruited by email to a web-based ¿Research Project on Student Health Behavior.¿ Respondents answered nine questions about their physical activity, diet, and smoking. They were unknowingly randomized to a group presented with either (A) three questions about their alcohol consumption or (B) seven questions about their alcohol dependence and problems (under a prominent header labeled ¿Alcohol Use Disorders Identification Test¿), followed by the same three alcohol consumption questions from (A). Results: A total of 3,594 students (mean age = 27, SD = 10) responded and were randomized: 1,778 to Group A and 1,816 to Group B. Outcome measures were the number of days they drank alcohol, the typical number of drinks they consumed per drinking day, and the number of days they consumed six or more drinks. The primary analysis included participants with any alcohol consumption in the preceding 4 weeks (1,304 in Group A; 1,340 in Group B) using between-group, two-tailed t tests. Results: In Groups A and B, respectively, means (and SDs) of the number of days drinking were 5.89 (5.92) versus 6.06 (6.12), p = .49; typical number of drinks per drinking day: 4.02 (3.87) versus 3.82 (3.76), p = .17; and number of days consuming six or more drinks: 1.69 (2.94) versus 1.67 (3.25), p = .56. Conclusions: We could not reject the null hypothesis because earlier questions about alcohol dependence and problems showed no sign of biasing the respondents¿ subsequent reports of alcohol consumption. These data support the validity of university students¿ reporting of alcohol consumption in web-based studies.

DOI 10.15288/jsad.2016.77.526
Citations Scopus - 2Web of Science - 3
Co-authors Kypros Kypri, Amanda Wilson
2016 Khan AA, Williams T, Savage L, Stewart P, Ashraf A, Davies AJ, et al., 'Pre-hospital thrombolysis in ST-segment elevation myocardial infarction: A regional Australian experience', Medical Journal of Australia, 205 121-125 (2016) [C1]

© 2016 AMPCo Pty Ltd. Objective: The system of care in the Hunter New England Local Health District for patients with ST-segment elevation myocardial infarction (STEMI) foresees ... [more]

© 2016 AMPCo Pty Ltd. Objective: The system of care in the Hunter New England Local Health District for patients with ST-segment elevation myocardial infarction (STEMI) foresees pre-hospital thrombolysis (PHT) administered by paramedics to patients more than 60 minutes from the cardiac catheterisation laboratory (CCL), and primary percutaneous coronary intervention (PCI) at the CCL for others. We assessed the safety and effectiveness of the pre-hospital diagnosis strategy, which allocates pati ents to PHT or primary PCI according to travel time to the CCL. Design, setting and participants: Prospective, non-randomised, consecutive, single-centre case series of STEMI patients diagnosed on the basis of a pre-hospital electrocardiogram (ECG), from August 2008 to August 2013. All patients were treated at the tertiary referral hospital (John Hunter Hospital, Newcastle). Main outcome measures: The primary efficacy endpoint was all-cause mortality at 12 months; the primary safety endpoint was bleeding. Results: STEMI was diagnosed in 484 patients on the basis of pre-hospital ECG; 150 were administered PHT and 334 underwent primary PCI. The median time from first medical contact (FMC) to PHT was 35 minutes (IQR, 28¿43 min) and to balloon inflation 130 minutes (IQR, 100¿150 min). In the PHT group, 37 patients (27%) needed rescue PCI (median time, 4 h; IQR, 3¿5 h). The 12-month all-cause mortality rate was 7.0% (PHT, 6.7%; PCI, 7.2%). The incidence of major bleeding (TIMI criteria) in the PHT group was 1.3%; no patients in the primary PCI group experienced major bleeding. Conclusion: PHT can be delivered safely by paramedical staff in regional and rural Australia with good clinical outcomes.

DOI 10.5694/mja15.01336
Citations Scopus - 1Web of Science - 3
Co-authors Andrew Boyle, Christopher Oldmeadow
2016 Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, et al., 'Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function', NATURE COMMUNICATIONS, 7 (2016) [C1]
DOI 10.1038/ncomms10023
Citations Scopus - 44Web of Science - 45
Co-authors Mark Mcevoy, Rodney Scott, Liz Holliday
2016 Minelli C, Dean CH, Hind M, Alves AC, Amaral AFS, Siroux V, et al., 'Association of Forced Vital Capacity with the Developmental Gene NCOR2', PLOS ONE, 11 e0147388-e0147388 (2016) [C1]
DOI 10.1371/journal.pone.0147388
Citations Scopus - 2
Co-authors Liz Holliday, Christopher Oldmeadow, Rodney Scott
2016 Kongtharvonskul J, Woratanarat P, McEvoy M, Attia J, Wongsak S, Kawinwonggowit V, Thakkinstian A, 'Efficacy of glucosamine plus diacerein versus monotherapy of glucosamine: a double-blind, parallel randomized clinical trial.', Arthritis Res Ther, 18 1-12 (2016) [C1]
DOI 10.1186/s13075-016-1124-9
Citations Scopus - 1Web of Science - 1
Co-authors Mark Mcevoy
2016 Handley TE, Ventura AD, Browne JL, Rich J, Attia JR, Reddy P, et al., 'Suicidal ideation reported by adults with Type 1 or Type 2 diabetes: results from Diabetes MILES¿Australia', Diabetic Medicine, 33 1582-1589 (2016) [C1]

© 2015 Diabetes UK Aims: To examine the prevalence and correlates of suicidal ideation (SI) in a community-based sample of adults with Type 1 or Type 2 diabetes. Methods: Partici... [more]

© 2015 Diabetes UK Aims: To examine the prevalence and correlates of suicidal ideation (SI) in a community-based sample of adults with Type 1 or Type 2 diabetes. Methods: Participants were 3338 adults aged 18¿70 years with Type 1 diabetes (n = 1376) or Type 2 diabetes (non-insulin: n = 1238; insulin: n = 724) from a national survey administered to a random sample registered with the National Diabetes Services Scheme. Depression and SI were assessed using the Patient Health Questionnaire, and diabetes-specific distress with the Problem Areas In Diabetes scale. Separate logistic regression analyses by diabetes type/treatment were used to determine relative contribution to SI. Results: Overall, we observed a SI rate of 14% in our sample. Participants with Type 2 diabetes using insulin reported more frequent depressive symptoms, and were more likely to report recent SI (19%) compared with those with either Type 1 diabetes or Type 2 diabetes not using insulin (14 and 12%, respectively). After controlling for depression, there was little difference in the prevalence of SI between diabetes types/treatments, but higher diabetes-specific distress significantly increased the odds of SI. Conclusions: As SI is a significant risk factor for a suicide attempt, the findings have implications for healthcare professionals, pointing to the importance of adequate screening and action plans for appropriate follow-up of those reporting depression. Our findings are also indicative of the psychological toll of diabetes more generally, and the need to integrate physical and mental healthcare for people with diabetes.

DOI 10.1111/dme.13022
Citations Scopus - 4Web of Science - 4
Co-authors Jane Rich
2016 Mather KA, Thalamuthu A, Oldmeadow C, Song F, Armstrong NJ, Poljak A, et al., 'Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults', Scientific Reports, 6 (2016) [C1]

Apolipoprotein H (ApoH) is a multi-functional plasma glycoprotein that has been associated with negative health outcomes. ApoH levels have high heritability. We undertook a genome... [more]

Apolipoprotein H (ApoH) is a multi-functional plasma glycoprotein that has been associated with negative health outcomes. ApoH levels have high heritability. We undertook a genome-wide association study of ApoH levels using the largest sample to date and replicated the results in an independent cohort (total N = 1,255). In the discovery phase, a meta-analysis of two cohorts, the Sydney Memory and Ageing Study (Sydney MAS) and the Older Australian Twins Study (OATS) (n = 942) revealed genome-wide significant results in or near the APOH gene on chromosome 17 (top SNP, rs7211380, p = 1 × 10 -11 ). The results were replicated in an independent cohort, the Hunter Community Study (p < 0.002) (n = 313). Conditional and joint analysis (COJO) confirmed the association of the chromosomal 17 region with ApoH levels. The set of independent SNPs identified by COJO explained 23% of the variance. The relationships between the top SNPs and cardiovascular/lipid/cognition measures and diabetes were assessed in Sydney MAS, with suggestive results observed for diabetes and cognitive performance. However, replication of these results in the smaller OATS cohort was not found. This work provides impetus for future research to better understand the contribution of genetics to ApoH levels and its possible impacts on health.

DOI 10.1038/srep23675
Citations Scopus - 1Web of Science - 2
Co-authors Liz Holliday, Rodney Scott, Peter Schofield, Mark Mcevoy, Christopher Oldmeadow
2015 Johnson NA, Kypri K, Latter J, McElduff P, Attia J, Saitz R, et al., 'Effect of telephone follow-up on retention and balance in an alcohol intervention trial', Preventive Medicine Reports, 2 746-749 (2015) [C1]

© 2015 The Authors. Objectives: Telephone follow-up is not currently recommended as a strategy to improve retention in randomized trials. The aims of this study were to estimate ... [more]

© 2015 The Authors. Objectives: Telephone follow-up is not currently recommended as a strategy to improve retention in randomized trials. The aims of this study were to estimate the effect of telephone follow-up on retention, identify participant characteristics predictive of questionnaire completion during or after telephone follow-up, and estimate the effect of including participants who provided follow-up data during or after telephone follow-up on balance between randomly allocated groups in a trial estimating the effect of electronic alcohol screening and brief intervention on alcohol consumption in hospital outpatients with hazardous or harmful drinking. Method: Trial participants were followed up 6. months after randomization (June-December 2013) using e-mails containing a hyperlink to a web-based questionnaire when possible and by post otherwise. Telephone follow-up was attempted after two written reminders and participants were invited to complete the questionnaire by telephone when contact was made. Results: Retention before telephone follow-up was 62.1% (520/837) and 82.8% (693/837) afterward: an increase of 20.7% (173/837). Therefore, 55% (95% CI 49%-60%) of the 317 participants who had not responded after two written reminders responded during or after the follow-up telephone call. Age. < . 55. years, a higher AUDIT-C score and provision of a mobile/cell phone number were predictive of questionnaire completion during or after telephone follow-up. Balance between randomly allocated groups was present before and after inclusion of participants who completed the questionnaire during or after telephone follow-up. Conclusion: Telephone follow-up improved retention in this randomized trial without affecting balance between the randomly allocated groups.

DOI 10.1016/j.pmedr.2015.08.016
Citations Scopus - 1
Co-authors A Dunlop, Patrick Mcelduff, Luke Wolfenden, Natalie Johnson, Kypros Kypri, Joanna Latter
2015 Kelly PJ, Baker AL, Deane FP, Callister R, Collins CE, Oldmeadow C, et al., 'Study protocol: A stepped wedge cluster randomised controlled trial of a healthy lifestyle intervention for people attending residential substance abuse treatment Health behavior, health promotion and society', BMC Public Health, 15 (2015) [C3]

© 2015 Kelly et al.; licensee BioMed Central. Background: Cardiovascular disease and cancer are leading causes of mortality for people with a history of alcohol or other substanc... [more]

© 2015 Kelly et al.; licensee BioMed Central. Background: Cardiovascular disease and cancer are leading causes of mortality for people with a history of alcohol or other substance use disorders. These chronic diseases share the same four primary behavioural risk factors i.e. excessive alcohol use, smoking, low intake of fruit and vegetables and physical inactivity. In addition to addressing problematic alcohol use, there is the potential for substance abuse treatment services to also address these other behaviours. Healthy Recovery is an 8-session group-based intervention that targets these multiple behavioural health risk factors and was developed specifically for people attending substance abuse treatment. This protocol describes a Cancer Institute NSW funded study that assesses the effectiveness of delivering Healthy Recovery for people who are attending residential alcohol and other substance abuse treatment. Methods/Design: The study uses a stepped wedge randomised controlled design, where randomisation occurs at the service level. Participants will be recruited from residential rehabilitation programs provided by The Australian Salvation Army. All participants who (1) currently smoke tobacco and (2) are expected to be in the residential program for the duration of the 5-week intervention will be asked to participate in the study. Those participants residing at the facilities assigned to the treatment condition will complete Healthy Recovery. The intervention is manual guided and will be delivered over a 5-week period, with participants attending 8 group sessions. All participants will continue to complete The Salvation Army residential program, a predominantly 12-step based, modified therapeutic community. Participants in the control condition will complete treatment as usual. Research staff blind to treatment allocation will complete the primary and secondary outcome assessments at baseline and then at weeks 8, 20 and 32 weeks post intervention. Discussion: This study will provide comprehensive data on the effect of delivering a healthy lifestyle intervention (i.e. Healthy Recovery) within a residential substance abuse setting. If shown to be effective, this intervention can be disseminated within other residential substance abuse programs. Trial registration: Australian and New Zealand Clinical Trials Register (ANZCTR): ACTRN12615000165583. Registered 19 th February 2015.

DOI 10.1186/s12889-015-1729-y
Citations Scopus - 4Web of Science - 4
Co-authors Robin Callister, Amanda Baker, Christopher Oldmeadow, Clare Collins
2015 Roselli S, Pundavela J, Demont Y, Faulkner S, Keene S, Attia J, et al., 'Sortilin is associated with breast cancer aggressiveness and contributes to tumor cell adhesion and invasion', Oncotarget, 6 10473-10486 (2015) [C1]

The neuronal membrane protein sortilin has been reported in a few cancer cell lines, but its expression and impact in human tumors is unclear. In this study, sortilin was analyzed... [more]

The neuronal membrane protein sortilin has been reported in a few cancer cell lines, but its expression and impact in human tumors is unclear. In this study, sortilin was analyzed by immunohistochemistry in a series of 318 clinically annotated breast cancers and 53 normal breast tissues. Sortilin was detected in epithelial cells, with increased levels in cancers, as compared to normal tissues (p = 0.0088). It was found in 79% of invasive ductal carcinomas and 54% of invasive lobular carcinomas (p < 0.0001). There was an association between sortilin expression and lymph node involvement (p = 0.0093), suggesting a relationship with metastatic potential. In cell culture, sortilin levels were higher in cancer cell lines compared to non-tumorigenic breast epithelial cells and siRNA knockdown of sortilin inhibited cancer cell adhesion, while proliferation and apoptosis were not affected. Breast cancer cell migration and invasion were also inhibited by sortilin knockdown, with a decrease in focal adhesion kinase and SRC phosphorylation. In conclusion, sortilin participates in breast tumor aggressiveness and may constitute a new therapeutic target against tumor cell invasion.

Citations Scopus - 5Web of Science - 5
Co-authors Marjorie Walker, Hubert Hondermarck, Xu Zhang, Chenchen Jiang
2015 Bidarian-Moniri A, Nilsson M, Rasmusson L, Attia J, Ejnell H, 'The effect of the prone sleeping position on obstructive sleep apnoea', ACTA OTO-LARYNGOLOGICA, 135 79-84 (2015) [C1]
DOI 10.3109/00016489.2014.962183
Citations Scopus - 3Web of Science - 3
Co-authors Michael Nilsson
2015 Squance ML, Reeves G, Attia J, Bridgman H, Guest M, 'Self-reported Lupus flare: Association with everyday home and personal product exposure', Toxicology Reports, 2 880-888 (2015) [C1]

© 2015 Published by Elsevier Ireland Ltd. Background: The number of chemicals in household products has driven concern about potential adverse health through their use. Most rese... [more]

© 2015 Published by Elsevier Ireland Ltd. Background: The number of chemicals in household products has driven concern about potential adverse health through their use. Most research concentrates on product chemicals with reproductive and carcinogenic consequences, however some evidence exists that immune effects can lead to exacerbation of autoimmune illnesses such as lupus (SLE). Objectives: This paper examines household and personal product exposure patterns in a pilot case/control study of female Australians. We also examined associations between common product exposure and SLE symptom exacerbation over a year period. Methods: We enrolled 41 control and 80 SLE participants aged 18-80 years. Qualitative techniques of structured interview and thematic analysis retrospectively explored patterns of product use, and flare history data of SLE participants. Negative binomial regression models explored associations between self-reported flare (SRF) days and exposure to 34 common home product groups. Results: Mean product counts did not differ between participant groups (mean 33.1: SD 11.8), or flare groups (flare mean 32.6:SD 12, no-flare 31.8:SD 6.6). Products used for personal hygiene and general house cleaning were most frequently used.Significant association with increased SRF day relative risk (IRR) was seen for bath oil use (IRR 1.008, CI 1.00-1.02). Paradoxical "protective" effects, (reduced SRF days) were found for cleansing beauty (IRR 0.999, CI 0.998-0.999), make-up (IRR 0.998, CI 0.997-0.999); adhesives (IRR 0.994, CI 0.991-0.997) and paint (IRR 0.99, CI 0.986-0.995). Conclusions: Everyday product exposures can impact on symptom exacerbation in SLE. Some offering protection and others increased health risk. Identifying environmental associations offer the possibility of life-style interventions to reduce illness impact.

DOI 10.1016/j.toxrep.2015.05.010
2015 Rannikmäe K, Davies G, Thomson PA, Bevan S, Devan WJ, Falcone GJ, et al., 'Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease', Neurology, 84 918-926 (2015) [C1]

© 2015 American Academy of Neurology. Objectives: We hypothesized that common variants in the collagen genes COL4A1/COL4A2 are associated with sporadic forms of cerebral small ve... [more]

© 2015 American Academy of Neurology. Objectives: We hypothesized that common variants in the collagen genes COL4A1/COL4A2 are associated with sporadic forms of cerebral small vessel disease. Methods: We conducted meta-analyses of existing genotype data among individuals of European ancestry to determine associations of 1,070 common single nucleotide polymorphisms (SNPs) in the COL4A1/COL4A2 genomic region with the following: intracerebral hemorrhage and its subtypes (deep, lobar) (1,545 cases, 1,485 controls); ischemic stroke and its subtypes (cardioembolic, large vessel disease, lacunar) (12,389 cases, 62,004 controls); and white matter hyperintensities (2,733 individuals with ischemic stroke and 9,361 from population-based cohorts with brain MRI data). We calculated a statistical significance threshold that accounted for multiple testing and linkage disequilibrium between SNPs (p < 0.000084). Results: Three intronic SNPs in COL4A2 were significantly associated with deep intracerebral hemorrhage (lead SNP odds ratio [OR] 1.29, 95% confidence interval [CI] 1.14-1.46, p = 0.00003; r 2 > 0.9 between SNPs). Although SNPs associated with deep intracerebral hemorrhage did not reach our significance threshold for association with lacunar ischemic stroke (lead SNP OR 1.10, 95% CI 1.03-1.18, p = 0.0073), and with white matter hyperintensity volume in symptomatic ischemic stroke patients (lead SNP OR 1.07, 95% CI 1.01-1.13, p = 0.016), the direction of association was the same. There was no convincing evidence of association with white matter hyperintensities in population-based studies or with non-small vessel disease cerebrovascular phenotypes. Conclusions: Our results indicate an association between common variation in the COL4A2 gene and symptomatic small vessel disease, particularly deep intracerebral hemorrhage. These findings merit replication studies, including in ethnic groups of non-European ancestry.

DOI 10.1212/WNL.0000000000001309
Citations Scopus - 18Web of Science - 15
Co-authors Christopher Levi, Liz Holliday
2015 Campbell BCV, Mitchell PJ, Kleinig TJ, Dewey HM, Churilov L, Yassi N, et al., 'Endovascular therapy for ischemic stroke with perfusion-imaging selection', New England Journal of Medicine, 372 1009-1018 (2015) [C1]

Copyright © 2015 Massachusetts Medical Society. Background: Trials of endovascular therapy for ischemic stroke have produced variable results. We conducted this study to test whe... [more]

Copyright © 2015 Massachusetts Medical Society. Background: Trials of endovascular therapy for ischemic stroke have produced variable results. We conducted this study to test whether more advanced imaging selection, recently developed devices, and earlier intervention improve outcomes. Methods: We randomly assigned patients with ischemic stroke who were receiving 0.9 mg of alteplase per kilogram of body weight less than 4.5 hours after the onset of ischemic stroke either to undergo endovascular thrombectomy with the Solitaire FR (Flow Restoration) stent retriever or to continue receiving alteplase alone. All the patients had occlusion of the internal carotid or middle cerebral artery and evidence of salvageable brain tissue and ischemic core of less than 70 ml on computed tomographic (CT) perfusion imaging. The coprimary outcomes were reperfusion at 24 hours and early neurologic improvement (.8-point reduction on the National Institutes of Health Stroke Scale or a score of 0 or 1 at day 3). Secondary outcomes included the functional score on the modified Rankin scale at 90 days. Results: The trial was stopped early because of efficacy after 70 patients had undergone randomization (35 patients in each group). The percentage of ischemic territory that had undergone reperfusion at 24 hours was greater in the endovascular-therapy group than in the alteplase-only group (median, 100% vs. 37%; P < 0.001). Endovascular therapy, initiated at a median of 210 minutes after the onset of stroke, increased early neurologic improvement at 3 days (80% vs. 37%, P = 0.002) and improved the functional outcome at 90 days, with more patients achieving functional independence (score of 0 to 2 on the modified Rankin scale, 71% vs. 40%; P = 0.01). There were no significant differences in rates of death or symptomatic intracerebral hemorrhage. Conclusions: In patients with ischemic stroke with a proximal cerebral arterial occlusion and salvageable tissue on CT perfusion imaging, early thrombectomy with the Solitaire FR stent retriever, as compared with alteplase alone, improved reperfusion, early neurologic recovery, and functional outcome. (Funded by the Australian National Health and Medical Research Council and others; EXTEND-IA ClinicalTrials.gov number, NCT01492725, and Australian New Zealand Clinical Trials Registry number, ACTRN12611000969965.)

DOI 10.1056/NEJMoa1414792
Citations Scopus - 1165Web of Science - 1070
Co-authors Neil Spratt, Christopher Levi, Mark Parsons
2015 Greenop KR, Bailey HD, Miller M, Scott RJ, Attia J, Ashton LJ, et al., 'Breastfeeding and nutrition to 2 years of age and risk of childhood acute lymphoblastic leukemia and brain tumors', Nutrition and Cancer, 67 431-441 (2015) [C1]

© 2015 Taylor &amp; Francis Group, LLC. Acute lymphoblastic leukemia (ALL) and childhood brain tumors (CBT) are 2 of the most common forms of childhood cancer, but little is kn... [more]

© 2015 Taylor & Francis Group, LLC. Acute lymphoblastic leukemia (ALL) and childhood brain tumors (CBT) are 2 of the most common forms of childhood cancer, but little is known of their etiology. In 2 nationwide case-control studies we investigated whether breastfeeding, age of food introduction, or early diet are associated with the risk of these cancers. Cases aged 0-14 years were identified from Australian pediatric oncology units between 2003 and 2007 (ALL) and 2005 and 2010 (CBT) and population-based controls through nationwide random-digit dialing. Mothers completed questionnaires giving details of infant feeding up to the age of 2 yr. Data from 322 ALL cases, 679 ALL controls, 299 CBT cases, and 733 CBT controls were analysed using unconditional logistic regression. Breastfeeding was associated with a reduced risk of ALL [odds ratio (OR) = 0.52, 95% confidence interval (CI): 0.32, 0.84), regardless of duration. Introduction of artificial formula within 14 days of birth was positively associated with ALL (OR = 1.57, 95% CI: 1.03, 2.37), as was exclusive formula feeding to 6 mo (OR = 1.81, 95% CI: 1.07, 3.05). No associations were seen between breastfeeding or formula use and risk of CBT. Our results suggest that breastfeeding and delayed introduction of artificial formula may reduce the risk of ALL but not CBT.

DOI 10.1080/01635581.2015.998839
Citations Scopus - 8Web of Science - 8
Co-authors Rodney Scott
2015 Bidarian-Moniri A, Nilsson M, Attia J, Ejnell H, 'Mattress and pillow for prone positioning for treatment of obstructive sleep apnoea', Acta Oto-Laryngologica, 135 271-276 (2015) [C1]

© 2015 Informa Healthcare. Conclusion: The new mattress and pillow for prone positioning (MPP) is efficient in reducing the apnoea-hypopnoea index (AHI) and oxygen desaturation i... [more]

© 2015 Informa Healthcare. Conclusion: The new mattress and pillow for prone positioning (MPP) is efficient in reducing the apnoea-hypopnoea index (AHI) and oxygen desaturation index (ODI) in most patients with obstructive sleep apnoea (OSA), with satisfactory compliance. Objective: The aim of the present study was to evaluate the effect of the prone body and head sleep position on severity of disease in patients with OSA after 4 weeks of adaptation to a mattress and pillow facilitating prone positioning. Methods: Fourteen patients with mild to severe OSA, 11 men and 3 women with a mean AHI of 26 (min, 6; max, 53) and mean ODI of 21 (min, 6; max, 51) were evaluated. Two polysomnographic (PSG) studies were performed. The first PSG study was without any treatment and the second was after 4 weeks of adaptation to the MPP for prone positioning of the body and the head. Results: Mean AHI and ODI decreased from 26 and 21 to 8 and 7, respectively (p < 0.001) with treatment. The mean time spent in the supine position was reduced from 128 to 10 min (p = 0.02) and the prone time increased from 42 to 174 min (p = 0.02) with the MPP. The mean total sleep time was 390 min during the first PSG study night without treatment and 370 min during the second night with the MPP (p = 0.7). Ten patients (71%) reduced their AHI by at least 50% and reached a value < 10 during treatment. All patients managed to sleep on the MPP for > 4 h per night during the 4-week study.

DOI 10.3109/00016489.2014.968674
Citations Scopus - 1
Co-authors Michael Nilsson
2015 Chan JPL, Thalamuthu A, Oldmeadow C, Armstrong NJ, Holliday EG, McEvoy M, et al., 'Genetics of hand grip strength in mid to late life', Age, 37 1-10 (2015) [C1]

© 2015, American Aging Association. Hand grip strength (GS) is a predictor of mortality in older adults and is moderately to highly heritable, but no genetic variants have been c... [more]

© 2015, American Aging Association. Hand grip strength (GS) is a predictor of mortality in older adults and is moderately to highly heritable, but no genetic variants have been consistently identified. We aimed to identify single nucleotide polymorphisms (SNPs) associated with GS in middle-aged to older adults using a genome-wide association study (GWAS). GS was measured using handheld dynamometry in community-dwelling men and women aged 55¿85 from the Hunter Community Study (HCS, N = 2088) and the Sydney Memory and Ageing Study (Sydney MAS, N = 541). Genotyping was undertaken using Affymetrix microarrays with imputation to HapMap2. Analyses were performed using linear regression. No genome-wide significant results were observed in HCS nor were any of the top signals replicated in Sydney MAS. Gene-based analyses in HCS identified two significant genes (ZNF295, C2CD2), but these results were not replicated in Sydney MAS. One out of eight SNPs previously associated with GS, rs550942, located near the CNTF gene, was significantly associated with GS (p = 0.005) in the HCS cohort only. Study differences may explain the lack of consistent results between the studies, including the smaller sample size of the Sydney MAS cohort. Our modest sample size also had limited power to identify variants of small effect. Our results suggest that similar to various other complex traits, many genetic variants of small effect size may influence GS. Future GWAS using larger samples and consistent measures may prove more fruitful at identifying genetic contributors for GS in middle-aged to older adults.

DOI 10.1007/s11357-015-9745-5
Citations Scopus - 3Web of Science - 3
Co-authors Roseanne Peel, Liz Holliday, Christopher Oldmeadow, Mark Mcevoy, Rodney Scott
2015 Greenop KR, Scott RJ, Attia J, Bower C, de Klerk NH, Norris MD, et al., 'Folate Pathway Gene Polymorphisms and Risk of Childhood Brain Tumors: Results from an Australian Case-Control Study', CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 24 931-937 (2015) [C1]
DOI 10.1158/1055-9965.EPI-14-1248
Citations Scopus - 2Web of Science - 2
Co-authors Rodney Scott
2015 Milne E, Greenop KR, Scott RJ, Haber M, Norris MD, Attia J, et al., 'Folate pathway gene polymorphisms, maternal folic acid use, and risk of childhood acute lymphoblastic leukemia', Cancer Epidemiology Biomarkers and Prevention, 24 48-56 (2015) [C1]

© 2014 American Association for Cancer Research. Background: Several studies suggest that maternal folic acid supplementation before or during pregnancy protects against childhoo... [more]

© 2014 American Association for Cancer Research. Background: Several studies suggest that maternal folic acid supplementation before or during pregnancy protects against childhood acute lymphoblastic leukemia (ALL). We investigated associations between ALL risk and folate pathway gene polymorphisms, and their modification by maternal folic acid supplements, in a population-based case-control study (2003-2007). Methods: All Australian pediatric oncology centers provided cases; controls were recruited by national random digit dialing. Data from 392 cases and 535 controls were included. Seven folate pathway gene polymorphisms (MTHFR 677C > T, MTHFR 1298A > C, MTRR 66A > G, MTR 2756 A > G, MTR 5049 C > A, CBS 844 Ins68, and CBS 2199 T > C) were genotyped in children and their parents. Information on prepregnancy maternal folic acid supplement use was collected. ORs were estimated with unconditional logistic regression adjusted for frequency-matched variables and potential confounders. Case-parent trios were also analyzed. Results: There was some evidence of a reduced risk of ALL among children who had, or whose father had, the MTRR 66GG genotype: ORs 0.60 [95% confidence interval (CI) 0.39-0.91] and 0.64 (95% CI, 0.40-1.03), respectively. The ORs for paternal MTHFR 677CT and TT genotypes were 1.41 (95% CI, 1.02-1.93) and 1.81 (95% CI, 1.06-3.07). ORs varied little by maternal folic acid supplementation. Conclusions: Some folate pathway gene polymorphisms in the child or a parent may influence ALL risk. While biologically plausible, underlying mechanisms for these associations need further elucidation. Impact: Folate pathway polymorphisms may be related to risk of childhood ALL, but larger studies are needed for conclusive results.

DOI 10.1158/1055-9965.EPI-14-0680
Citations Scopus - 4Web of Science - 1
Co-authors Rodney Scott
2015 Kongtharvonskul J, Anothaisintawee T, McEvoy M, Attia J, Woratanarat P, Thakkinstian A, 'Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: A systematic review and network meta-analysis', European Journal of Medical Research, 20 (2015) [C1]

© 2015 Kongtharvonskul et al.; licensee BioMed Central. Background: To conduct a systematic review and network meta-analysis of randomized controlled trials (RCTs) with the aims ... [more]

© 2015 Kongtharvonskul et al.; licensee BioMed Central. Background: To conduct a systematic review and network meta-analysis of randomized controlled trials (RCTs) with the aims of comparing relevant clinical outcomes (that is, visual analog scores (VAS), total and sub-Western Ontario and McMaster Universities Osteo arthritis index (WOMAC) scores, Lequesne algofunctional index, joint space width change, and adverse events) between diacerein, glucosamine, and placebo. Methods: Medline and Scopus databases were searched from inception to 29 August 2014, using PubMed and Scopus search engines and included RCTs or quasi-experimental designs comparing clinical outcomes between treatments. Data were extracted from original studies. A network meta-analysis was performed by applying weight regression for continuous outcomes and a mixed-effect Poisson regression for dichotomous outcomes. Results: Thirty-one of 505 identified studies were eligible. Compared to placebo, glucosamine showed a significant improvement with unstandardized mean differences (UMD) in total WOMAC, pain WOMAC, function WOMAC, and Lequesne score of -2.49 (95% confidence interval (CI) -4.14, -0.83), -0.75 (95% CI: -1.18, -0.32), -4.78 (95% CI: -5.96, -3.59), and -1.03 (95% CI: -1.34, -0.72), respectively. Diacerein clinically improves visual analog scores, function WOMAC, and stiffness WOMAC with UMD values of -2.23 (95% CI: -2.82, -1.64), -6.64 (95% CI: -10.50, -2.78), and -0.68 (95% CI: -1.20, -0.16) when compared to placebo. Conclusions: The network meta-analysis suggests that diacerein and glucosamine are equally efficacious for symptom relief in knee OA, but that the former has more side effects.

DOI 10.1186/s40001-015-0115-7
Citations Scopus - 9Web of Science - 11
2015 Mansour D, Mansour KG, Kenny BW, Attia J, Meads B, 'Driving with a short arm cast in a simulator', JOURNAL OF ORTHOPAEDIC SURGERY, 23 327-330 (2015) [C1]
2015 Davies G, Armstrong N, Bis JC, Bressler J, Chouraki V, Giddaluru S, et al., 'Genetic contributions to variation in general cognitive function: A meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)', Molecular Psychiatry, 20 183-192 (2015) [C1]

© 2015 Macmillan Publishers Limited. General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic c... [more]

© 2015 Macmillan Publishers Limited. General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait in middle-aged and older adults. We conducted a meta-analysis of genome-wide association studies of 31 cohorts (N=53 949) in which the participants had undertaken multiple, diverse cognitive tests. A general cognitive function phenotype was tested for, and created in each cohort by principal component analysis. We report 13 genome-wide significant single-nucleotide polymorphism (SNP) associations in three genomic regions, 6q16.1, 14q12 and 19q13.32 (best SNP and closest gene, respectively: rs10457441, P=3.93 × 10 < sup > -9 < /sup > , MIR2113; rs17522122, P=2.55 × 10 < sup > -8 < /sup > , AKAP6; rs10119, P=5.67 × 10 < sup > -9 < /sup > , APOE/TOMM40). We report one gene-based significant association with the HMGN1 gene located on chromosome 21 (P=1 × 10 < sup > -6 < /sup > ). These genes have previously been associated with neuropsychiatric phenotypes. Meta-analysis results are consistent with a polygenic model of inheritance. To estimate SNP-based heritability, the genome-wide complex trait analysis procedure was applied to two large cohorts, the Atherosclerosis Risk in Communities Study (N=6617) and the Health and Retirement Study (N=5976). The proportion of phenotypic variation accounted for by all genotyped common SNPs was 29% (s.e.=5%) and 28% (s.e.=7%), respectively. Using polygenic prediction analysis, ~1.2% of the variance in general cognitive function was predicted in the Generation Scotland cohort (N=5487; P=1.5 × 10 < sup > -17 < /sup > ). In hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with Alzheimer's disease: TOMM40, APOE, ABCG1 and MEF2C.

DOI 10.1038/mp.2014.188
Citations Scopus - 72Web of Science - 67
Co-authors Rodney Scott, Liz Holliday, Peter Schofield, Christopher Oldmeadow
2015 Sharpley C, Hussain R, Wark S, Mcevoy M, Attia J, 'THE INFLUENCE OF SOCIAL SUPPORT ON PSYCHOLOGICAL DISTRESS IN OLDER PERSONS: AN EXAMINATION OF INTERACTION PROCESSES IN AUSTRALIA.', Psychol Rep, 117 883-896 (2015) [C1]
DOI 10.2466/21.10.PR0.117c27z5
Citations Scopus - 2Web of Science - 1
Co-authors Mark Mcevoy
2015 Sapkota Y, Attia J, Gordon SD, Henders AK, Holliday EG, Rahmioglu N, et al., 'Genetic burden associated with varying degrees of disease severity in endometriosis', MOLECULAR HUMAN REPRODUCTION, 21 594-602 (2015) [C1]
DOI 10.1093/molehr/gav021
Citations Scopus - 10Web of Science - 8
Co-authors Rodney Scott, Mark Mcevoy, Liz Holliday
2015 Greenop KR, Hinwood AL, Fritschi L, Scott RJ, Attia J, Ashton LJ, et al., 'Vehicle refuelling, use of domestic wood heaters and the risk of childhood brain tumours: Results from an Australian case-control study', Pediatric Blood and Cancer, 62 229-234 (2015) [C1]

© 2014 Wiley Periodicals, Inc. The aetiology of childhood brain tumours (CBT) is largely unknown. Damage to germ cells after parental exposure to airborne carcinogens, such as vo... [more]

© 2014 Wiley Periodicals, Inc. The aetiology of childhood brain tumours (CBT) is largely unknown. Damage to germ cells after parental exposure to airborne carcinogens, such as volatile organic compounds and polycyclic aromatic hydrocarbons is one plausible pathway. This analysis aimed to investigate whether parental refuelling of vehicles or the use of domestic wood heaters in key time periods relating to the child's birth was associated with an increased risk of CBT. Procedure: Cases < 15 years of age were recruited through 10 paediatric oncology centres around Australia; controls were recruited through nationwide random-digit dialling, frequency matched to cases on age, sex and State of residence. Exposure to refuelling and wood heaters was ascertained through questionnaires from both parents. Odds ratios (ORs) and confidence intervals (CIs) were estimated using unconditional logistic regression, adjusting for relevant covariates. Results: Data were available for 306 case and 950 control families. Paternal refuelling =4times/month was associated with an increased risk of CBT (OR 1.59, 95% CI: 1.11, 2.29), and a dose-dependent trend was observed (P=0.004). No association was seen for maternal refuelling. Use of closed, but not open, wood heaters before (OR 1.51, 95% CI: 1.05, 2.15) and after (OR 1.44, 95% CI: 1.03, 2.01) the child's birth was associated with increased risk of CBT, but dose-response relationships were weak or absent. Conclusions: Paternal refuelling of vehicles =4times/month and the use of closed wood heaters before the child's birth may increase the risk of CBT. Replication in larger studies is needed.

DOI 10.1002/pbc.25268
Citations Scopus - 2Web of Science - 2
Co-authors Rodney Scott
2015 Vejakama P, Ingsathit A, Attia J, Thakkinstian A, 'Epidemiological study of chronic kidney disease progression: A large-scale population-based cohort study', Medicine (United States), 94 (2015) [C1]

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. The prognostic information about CKD progression, particularly for GFR categories 1 and 2, is still limited. Thi... [more]

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. The prognostic information about CKD progression, particularly for GFR categories 1 and 2, is still limited. This cohort was therefore conducted to determine the CKD progression using a competing risk approach. We conducted a retrospective cohort study linking community health screening with hospitals and death registry data in a province of Thailand, from 1997 to 2011. A competing risk model was applied by treating death as a competing risk factor to estimate 2-, 5-, and 10-year probability of kidney failure and median time for CKD progression from lower to higher GFR category. There were 17,074 non-diabetic and 15,032 diabetic CKD subjects. Diabetic subjects progressed more rapidly through GFR categories with the median times for CKD progression from GFR categories G1 to G2, G2 to G3a, G3a to G3b, G3b to G4, and G4 to G5 of 4.4, 6.1, 4.9, 6.3, and 9.0 years, respectively. Non-diabetic subjects took longertoprogress with the corresponding median timeof9.4, 14.0, 11.0, 13.8, and > 14.3 years. After adjusting for confounders, diabetic subjects were 49% (cause-specific hazard ratio ( < inf > c < /inf > HR) = 1.49, 95% CI: 1.37, 1.62) more likely to develop kidney failure than non-diabetic subjects. Albuminuria categories A3 and A2 were, respectively, 3.40 (95% CI: 3.07, 3.76) and 1.71 (95% CI: 1.53, 1.92) higher risk of kidney failure when compared to A1. For each albumin category, death rate increased as albuminuria increased particularly in diabetic subjects, which was approximately 2 times higher in A3 compared to A1. Considering GFR category, it gradually increased from G1 to G4 and sharply increased from G4 to G5 in both non-diabetic and diabetic subjects. This study has quantified CKD progression in an Asian population within ordinary practice. Diabetic subjects progress through GFR and albuminuria categories and reach kidney failure about twice as rapidly as non-diabetic subjects.

DOI 10.1097/MD.0000000000000475
Citations Scopus - 3Web of Science - 4
2015 Delahunt B, Egevad L, Srigley JR, Steigler A, Murray JD, Atkinson C, et al., 'Validation of International Society of Urological Pathology (ISUP) grading for prostatic adenocarcinoma in thin core biopsies using TROG 03.04 'RADAR' trial clinical data', Pathology, 47 520-525 (2015) [C1]

Copyright © 2015 Royal College of Pathologists of Australasia. All rights reserved. In 2014 a consensus conference convened by the International Society of Urological Pathology (... [more]

Copyright © 2015 Royal College of Pathologists of Australasia. All rights reserved. In 2014 a consensus conference convened by the International Society of Urological Pathology (ISUP) adopted amendments to the criteria for Gleason grading and scoring (GS) for prostatic adenocarcinoma. The meeting defined a modified grading system based on 5 grading categories (grade 1, GS 3+3; grade 2, GS 3+4; grade 3, GS 4+3; grade 4, GS 8; grade 5, GS 9-10). In this study we have evaluated the prognostic significance of ISUP grading in 496 patients enrolled in the TROG 03.04 RADAR Trial. There were 19 grade 1, 118 grade 2, 193 grade 3, 88 grade 4 and 79 grade 5 tumours in the series, with follow-up for a minimum of 6.5 years. On follow-up 76 patients experienced distant progression of disease, 171 prostate specific antigen (PSA) progression and 39 prostate cancer deaths. In contrast to the 2005 modified Gleason system (MGS), the hazards of the distant and PSA progression endpoints, relative to grade 2, were significantly greater for grades 3, 4 and 5 of the 2014 ISUP grading scheme. Comparison of predictive ability utilising Harrell's concordance index, showed 2014 ISUP grading to significantly out-perform 2005 MGS grading for each of the three clinical endpoints.

DOI 10.1097/PAT.0000000000000318
Citations Scopus - 17Web of Science - 18
Co-authors Allison Steigler, Jim Denham
2015 Muenchhoff J, Poljak A, Song F, Raftery M, Brodaty H, Duncan M, et al., 'Plasma protein profiling of mild cognitive impairment and Alzheimer's disease across two independent cohorts', Journal of Alzheimer's Disease, 43 1355-1373 (2015) [C1]
DOI 10.3233/JAD-141266
Citations Scopus - 22Web of Science - 23
Co-authors Peter Schofield, Mark Mcevoy
2015 Peyrot WJ, Lee SH, Milaneschi Y, Abdellaoui A, Byrne EM, Esko T, et al., 'The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects', Molecular Psychiatry, 20 735-743 (2015)

An association between lower educational attainment (EA) and an increased risk for depression has been confirmed in various western countries. This study examines whether pleiotro... [more]

An association between lower educational attainment (EA) and an increased risk for depression has been confirmed in various western countries. This study examines whether pleiotropic genetic effects contribute to this association. Therefore, data were analyzed from a total of 9662 major depressive disorder (MDD) cases and 14 949 controls (with no lifetime MDD diagnosis) from the Psychiatric Genomics Consortium with additional Dutch and Estonian data. The association of EA and MDD was assessed with logistic regression in 15 138 individuals indicating a significantly negative association in our sample with an odds ratio for MDD 0.78 (0.75-0.82) per standard deviation increase in EA. With data of 884 105 autosomal common single-nucleotide polymorphisms (SNPs), three methods were applied to test for pleiotropy between MDD and EA: (i) genetic profile risk scores (GPRS) derived from training data for EA (independent meta-analysis on ~120 000 subjects) and MDD (using a 10-fold leave-one-out procedure in the current sample), (ii) bivariate genomic-relationship-matrix restricted maximum likelihood (GREML) and (iii) SNP effect concordance analysis (SECA). With these methods, we found (i) that the EA-GPRS did not predict MDD status, and MDD-GPRS did not predict EA, (ii) a weak negative genetic correlation with bivariate GREML analyses, but this correlation was not consistently significant, (iii) no evidence for concordance of MDD and EA SNP effects with SECA analysis. To conclude, our study confirms an association of lower EA and MDD risk, but this association was not because of measurable pleiotropic genetic effects, which suggests that environmental factors could be involved, for example, socioeconomic status.

DOI 10.1038/mp.2015.50
Citations Scopus - 6
Co-authors Liz Holliday, Rodney Scott
2015 Denham JW, Steigler A, Joseph D, Lamb DS, Spry NA, Duchesne G, et al., 'Radiation dose escalation or longer androgen suppression for locally advanced prostate cancer? Data from the TROG 03.04 RADAR trial', Radiotherapy and Oncology, 115 301-307 (2015) [C1]
DOI 10.1016/j.radonc.2015.05.016
Citations Scopus - 20Web of Science - 17
Co-authors Jim Denham, Liz Holliday, Christopher Oldmeadow, Allison Steigler
2015 Hiles SA, Baker AL, de Malmanche T, McEvoy M, Boyle M, Attia J, 'Unhealthy lifestyle may increase later depression via inflammation in older women but not men', Journal of Psychiatric Research, 63 65-74 (2015) [C1]

© 2015 Elsevier Ltd. Depression and inflammatory markers have a reliable cross-sectional association although less is known about the prospective relationship. The current study ... [more]

© 2015 Elsevier Ltd. Depression and inflammatory markers have a reliable cross-sectional association although less is known about the prospective relationship. The current study investigated whether pro-inflammatory markers are prospectively associated with depression, and whether indicators of unhealthy lifestyle, physical health and psychosocial functioning may drive this association. Participants were drawn from the Hunter Community Study, a community-dwelling cohort of individuals aged 55-85 years (N=1410). Participants completed baseline physiological assessment, health-related questionnaires, and blood sampling for the analysis of inflammatory markers, C-reactive protein (CRP) and interleukin (IL)-6. Participants completed the same depressive symptom questionnaire again after 3.5-5.5 years. Depression outcomes at follow-up were analysed dichotomously using established scale cut-off scores and continuously as a "residual score", representing the variation in follow-up depressive symptoms not explained by baseline symptoms and age. Analyses were conducted on males and females separately. At baseline, indicators of unhealthy lifestyle, physical health and psychosocial functioning were associated with depressive symptoms and inflammatory markers. For males, there were no relationships between inflammatory markers and follow-up depression outcomes. In females, IL-6 was significantly associated with depression outcomes in univariate, but not multivariate analyses. However, IL-6 significantly mediated the association between the predictors of waist-to-hip ratio, smoking and psychological coping at baseline, and follow-up depression outcomes. The results support the inflammatory hypothesis of depression, although females may be more vulnerable to effects. The findings raise the possibility that unhealthy lifestyle and psychosocial stress may drive inflammation and subsequent depressive symptoms.

DOI 10.1016/j.jpsychires.2015.02.010
Citations Scopus - 6Web of Science - 5
Co-authors Amanda Baker, Mark Mcevoy, Sarah Hiles
2015 Nead KT, Sharp SJ, Thompson DJ, Painter JN, Savage DB, Semple RK, et al., 'Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis.', Journal of the National Cancer Institute, 107 (2015) [C1]
DOI 10.1093/jnci/djv178
Citations Scopus - 24Web of Science - 13
Co-authors Rodney Scott, Mark Mcevoy, Liz Holliday
2015 Ren S, Newby D, Li SC, Walkom E, Miller P, Hure A, Attia J, 'Effect of the adult pneumococcal polysaccharide vaccine on cardiovascular disease: a systematic review and meta-analysis.', Open Heart, 2 1-9 (2015) [C1]
DOI 10.1136/openhrt-2015-000247
Co-authors Shuchuen Li, Emily Walkom, Alexis Hure, David Newby
2015 Kypri K, Wilson A, Attia J, Sheeran PJ, McCambridge J, 'Effects of study design and allocation on self-reported alcohol consumption: Randomized trial', Trials, 16 (2015) [C1]

© Kypri et al. Background: What participants think about the nature of a study might affect their behaviour and bias findings. We tested two hypotheses: (1) participants told the... [more]

© Kypri et al. Background: What participants think about the nature of a study might affect their behaviour and bias findings. We tested two hypotheses: (1) participants told they were in an intervention trial would report lower alcohol consumption at follow-up than those told they were in a cohort study; (2) participants told they were in the intervention group in a trial would have lower alcohol consumption at follow-up than those told they were in the control group. Methods: Students from four universities (N = 72,903) were invited to participate in a 'research project on student drinking'. Of 10,415 respondents, 6,788 were moderate to heavy drinkers and were randomized. Group A ('cohort') were informed their drinking would be assessed at baseline and again in one month. Group B ('control') were told the study was an intervention trial and they were in the control group. Group C ('intervention') were told the study was an intervention trial and they were to receive the intervention. All were assessed and directed to read identical online alcohol education material. Whether and how long they accessed the material were recorded. One month later, alcohol intake was reassessed. Results: In relation to hypothesis 1, there were no differences between the groups on the prespecified outcome measures. In relation to hypothesis 2, there were no differences though all point estimates were in the hypothesized direction (that is, 'intervention' < 'control'). The 'cohort' and 'control' groups accessed the material to a similar extent (59% versus 57%) while the 'intervention' group were more likely to access it (78%) and to read it for longer (median 35 s (25th and 75th percentiles: 6, 97) versus medians of 7 s (0, 28) and 8 s (4, 42) for the 'cohort' and 'control' groups, respectively). Conclusions: Although the context given to the research participants significantly influenced access to the online information and reading time, this did not translate into any effect on drinking behaviour, for either hypothesis. This might be because of failure in the experimental paradigm or the possibility of weaker effects using the online approach.

DOI 10.1186/s13063-015-0642-0
Co-authors Amanda Wilson, Kypros Kypri
2015 Dunn A, Marsden DL, Nugent E, Van Vliet P, Spratt NJ, Attia J, Callister R, 'Protocol variations and six-minute walk test performance in stroke survivors: A systematic review with meta-analysis', Stroke Research and Treatment, 2015 1-28 (2015) [C1]
DOI 10.1155/2015/484813
Citations Scopus - 15Web of Science - 2
Co-authors Neil Spratt, Paulette Vanvliet, Robin Callister
2015 Briggs S, Pearce R, Dilworth S, Higgins I, Hullick C, Attia J, 'Clinical pharmacist review: A randomised controlled trial', EMA - Emergency Medicine Australasia, 27 419-426 (2015) [C1]

© 2015 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine. Objectives: To determine if medication review by a clinical pharmacist of olde... [more]

© 2015 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine. Objectives: To determine if medication review by a clinical pharmacist of older patients in the ED impacted on admission to hospital and other outcomes. Methods: A stratified, randomised controlled study comparing the intervention to current practice. A tertiary referral ED in New South Wales, Australia. Older people ( > 70 years) living at home who initially reported taking greater than five medications. Medication review by an experienced hospital pharmacist within the ED. Rate of admission, rate of readmission, length of stay and admission to an aged care facility at 4 months post presentation, and rate of general practitioner acceptance of pharmacist recommendations. Results: The odds of admission decreased for those receiving the intervention (odds ratio [OR] = 0.68, 95% confidence interval [CI] : 0.53, 0.87; P = 0.002). There was no evidence that the intervention affected hospital length of stay for admitted patients (0.09 days change, 95% CI -0.08, 0.25; P = 0.31), the rate of re-presentation (0.08% change, 95% CI -0.12, 0.28; P = 0.44) or admission to an aged care facility. The odds of admission to an aged care facility increased with the Identification of Seniors at Risk score. General practitioners adopted 49% of pharmacists' recommendations. Conclusions: The presence of an experienced pharmacist in the ED reduced hospital admissions. Further study is required to determine longer term impacts of General Medical Practitioner acceptance of pharmacists' recommendations.

DOI 10.1111/1742-6723.12451
Citations Scopus - 5Web of Science - 3
Co-authors Isabel Higgins
2015 Vashum KP, McEvoy MA, Hancock SJ, Islam MR, Peel R, Attia JR, Milton AH, 'Prevalence of and associations with excessive daytime sleepiness in an Australian older population', Asia-Pacific Journal of Public Health, 27 NP2275-NP2284 (2015) [C1]

© 2013 APJPH. The aim of this research is to estimate the prevalence of excessive daytime sleepiness in an older population and associations with sociodemographic, health, and li... [more]

© 2013 APJPH. The aim of this research is to estimate the prevalence of excessive daytime sleepiness in an older population and associations with sociodemographic, health, and lifestyle factors using a cross-sectional, population-based study. Participants were men (1560) and women (1759), aged 55 to 85 years, enrolled in the Hunter Community Study, a longitudinal study of aging. Measurements were self-reported questionnaires, biochemical measures, and clinical measures. Of the 3319 participants, 3053 participants completed the Epworth Sleepiness Scale questionnaire. The prevalence of excessive daytime sleepiness was 15.3% overall and this was higher in males. In adjusted multivariate analysis, gender, working full time, body mass index, high-density and low-density lipoprotein cholesterol, Center for Epidemiologic Studies-Depression scale score, and Kessler psychological distress score were associated with excessive daytime sleepiness. Given the high prevalence of excessive daytime sleepiness observed in this study, further investigation and/or interventions to reduce adverse health outcomes, especially in males is warranted.

DOI 10.1177/1010539513497783
Citations Scopus - 8Web of Science - 4
Co-authors Mark Mcevoy, Roseanne Peel, Milton Hasnat
2015 Abdullah N, Abdul Murad NA, Attia J, Oldmeadow C, Mohd Haniff EA, Syafruddin SE, et al., 'Characterizing the genetic risk for Type 2 diabetes in a Malaysian multi-ethnic cohort.', Diabet Med, 32 1377-1384 (2015) [C1]
DOI 10.1111/dme.12735
Citations Scopus - 1Web of Science - 1
Co-authors Liz Holliday, Christopher Oldmeadow, Rodney Scott
2015 van Dyk M, Mangoni AA, McEvoy M, Attia JR, Sorich MJ, Rowland A, 'Targeted arginine metabolomics: A rapid, simple UPLC-QToF-MS<sup>E</sup> based approach for assessing the involvement of arginine metabolism in human disease', Clinica Chimica Acta, 447 59-65 (2015) [C1]

© 2015 Elsevier B.V.. Background: Nitric oxide synthase (NOS) mediated conversion of arginine (ARG) to citrulline (CIT) is a key pathway for nitric oxide synthesis. ARG is also m... [more]

© 2015 Elsevier B.V.. Background: Nitric oxide synthase (NOS) mediated conversion of arginine (ARG) to citrulline (CIT) is a key pathway for nitric oxide synthesis. ARG is also metabolised by alternate pathways to ornithine (ORN), homoarginine (HMA), N < sup > G < /sup > -monomethyl-L-arginine (MMA), N < sup > G < /sup > ,. N < sup > G < /sup > -dimethyl-L-arginine (ADMA) and N < sup > G < /sup > ,. N < sup > G < /sup > '-dimethyl-L-arginine (SDMA), all of which have the capacity to alter NOS activity. Simultaneous assessment of these analytes, when assessing the impact of arginine metabolism in human disease states, is desirable. Methods: Analytes (ARG, ADMA, SDMA, MMA, HMA, CIT and ORN) were isolated from human plasma by solvent extraction, evaporated and reconstituted. Ultra-performance liquid chromatography (UPLC) was performed on a 150mm×2.1mm T3 HSS column using a gradient mobile phase comprising ammonium formate (10mM, pH3.8) in methanol (1% to 63%). Analytes were detected by time-of-flight mass spectrometry (Q-ToF-MS) in positive ion mode with electrospray ionisation (ESI+). Data were collected using MS < sup > E < /sup > . Results: Solvent extraction provided high recovery ( > 95%). UPLC-QToF-MS < sup > E < /sup > facilitated the separation and quantification of the 7 analytes in an analysis time of 6min. The approach has high sensitivity; LOQ range from 0.005µM (NMMA) to 0.25µM (ARG and ORN), and good precision; intra- and inter-day %RSD are < 6% for all analytes. Conclusions: This approach provides the capacity to quantify 7 key compounds involved in ARG metabolism in a small sample volume, with a short total analysis time. These characteristics make this approach ideal for undertaking a comprehensive characterisation of this pathway in large data sets (e.g. population studies).

DOI 10.1016/j.cca.2015.05.014
Citations Scopus - 4Web of Science - 2
Co-authors Mark Mcevoy
2015 Cheng YC, Anderson CD, Bione S, Keene K, Maguire JM, Nalls M, et al., 'Are myocardial infarction-associated single-nucleotide polymorphisms associated with ischemic stroke? (vol 43, pg 980, 2012)', STROKE, 46 E204-E204 (2015) [C3]
DOI 10.1161/STR.0000000000000073
Co-authors Lisa Lincz, Pablo Moscato, Christopher Levi, Liz Holliday
2015 Hiles SA, Baker AL, de Malmanche T, McEvoy M, Boyle M, Attia J, 'The role of inflammatory markers in explaining the association between depression and cardiovascular hospitalisations', Journal of Behavioral Medicine, 38 609-619 (2015) [C1]

© 2015, Springer Science+Business Media New York. This study investigated whether inflammation may explain the relationship between depression and incident cardiovascular hospita... [more]

© 2015, Springer Science+Business Media New York. This study investigated whether inflammation may explain the relationship between depression and incident cardiovascular hospitalisations. Participants (55¿85¿years) completed baseline depression and physical assessment. Those without self-reported cardiovascular events were followed prospectively for hospital admissions for angina, myocardial infarction and cerebral infarction (median 937¿days). Across 5140 person-years of risk (N¿=¿1692), there were 47 incident cardiovascular hospitalisations (2.8¿%). Controlling for age and gender, interleukin (IL)-6, C-reactive protein (CRP), body mass index (BMI) and waist-to-hip ratio were associated with future cardiovascular events. Mediation analysis showed that CRP accounted for 8.1¿% and IL-6 10.9¿% of the effect of depression on cardiovascular events, and including the indirect effect in the model substantially reduced the direct relationship between depression and cardiovascular hospitalisations. BMI and waist-to-hip ratio accounted for indirect effects of 7.7 and 10.4¿%, respectively. Inflammatory markers partly explain the association between depression and cardiovascular events, although other shared factors also likely contribute.

DOI 10.1007/s10865-015-9637-2
Citations Scopus - 3Web of Science - 3
Co-authors Mark Mcevoy, Sarah Hiles, Amanda Baker
2015 Debette S, Ibrahim Verbaas CA, Bressler J, Schuur M, Smith A, Bis JC, et al., 'Genome-wide studies of verbal declarative memory in nondemented older people: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium', Biological Psychiatry, 77 749-763 (2015) [C1]

© 2015 Society of Biological Psychiatry. BACKGROUND: Memory performance in older persons can reflect genetic influences on cognitive function and dementing processes. We aimed to... [more]

© 2015 Society of Biological Psychiatry. BACKGROUND: Memory performance in older persons can reflect genetic influences on cognitive function and dementing processes. We aimed to identify genetic contributions to verbal declarative memory in a community setting. METHODS: We conducted genome-wide association studies for paragraph or word list delayed recall in 19 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, comprising 29,076 dementia- and stroke-free individuals of European descent, aged =45 years. Replication of suggestive associations (p < 5 × 10 -6 ) was sought in 10,617 participants of European descent, 3811 African-Americans, and 1561 young adults. RESULTS: rs4420638, near APOE, was associated with poorer delayed recall performance in discovery (p = 5.57 × 10 -10 ) and replication cohorts (p = 5.65 × 10 -8 ). This association was stronger for paragraph than word list delayed recall and in the oldest persons. Two associations with specific tests, in subsets of the total sample, reached genome-wide significance in combined analyses of discovery and replication (rs11074779 [HS3ST4], p = 3.11 × 10 -8 , and rs6813517 [SPOCK3], p = 2.58 × 10 -8 ) near genes involved in immune response. A genetic score combining 58 independent suggestive memory risk variants was associated with increasing Alzheimer disease pathology in 725 autopsy samples. Association of memory risk loci with gene expression in 138 human hippocampus samples showed cis-associations with WDR48 and CLDN5, both related to ubiquitin metabolism. CONCLUSIONS: This largest study to date exploring the genetics of memory function in ~40,000 older individuals revealed genome-wide associations and suggested an involvement of immune and ubiquitin pathways.

DOI 10.1016/j.biopsych.2014.08.027
Citations Scopus - 15Web of Science - 12
Co-authors Liz Holliday, Rodney Scott, Peter Schofield, Christopher Oldmeadow, Mark Mcevoy
2015 Greenop KR, Miller M, Bailey HD, Scott RJ, Attia J, Bower C, et al., 'Paternal dietary folate, B6 and B12 intake, and the risk of childhood brain tumors', Nutrition and Cancer, 67 224-230 (2015) [C1]

© 2015, Taylor &amp; Francis Group, LLC. It is biologically plausible that a paternal preconception diet low in nutrients related to DNA integrity could affect sperm DNA and su... [more]

© 2015, Taylor & Francis Group, LLC. It is biologically plausible that a paternal preconception diet low in nutrients related to DNA integrity could affect sperm DNA and subsequently risk of cancer in the offspring. The aim of this analysis was to investigate whether paternal preconception dietary folate, B6, or B12 intake was associated with the risk of childhood brain tumors (CBT) in an Australian case-control study. Cases < 15 years of age were recruited from 10 Australian pediatric oncology centers between 2005 and 2010, and controls from random-digit dialing, frequency-matched to cases on age, sex, and state of residence. Paternal dietary information was obtained by food-frequency questionnaires. Nutrient values were energy adjusted and divided into tertiles for analysis by unconditional logistic regression. In fathers with relevant data (237 cases and 629 controls), no association with dietary folate and B6 and risk of CBT was seen; high B12 intake was associated with an increased risk of CBT (odds ratio highest vs. lowest tertile: 1.74, 95% confidence interval: 1.14, 2.66) without an increasing trend. These results do not support the hypothesis that paternal dietary folate intake influences the risk of CBT. The increased OR observed between dietary B12 intake and risk of CBT is without any certain explanation.

DOI 10.1080/01635581.2015.990571
Citations Scopus - 1Web of Science - 1
Co-authors Rodney Scott
2015 Pundavela J, Roselli S, Faulkner S, Attia J, Scott RJ, Thorne RF, et al., 'Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer', Molecular Oncology, 9 1626-1635 (2015) [C1]
DOI 10.1016/j.molonc.2015.05.001
Citations Scopus - 4Web of Science - 3
Co-authors Marjorie Walker, Rodney Scott, Rick Thorne, Phillip Jobling, John Forbes, Hubert Hondermarck
2015 Smith S, Pockney P, Attia J, 'Corrigendum: A Meta-analysis on the Effect of Sham Feeding Following Colectomy: Should Gum Chewing Be Included in Enhanced Recovery After Surgery Protocols?', Diseases of the colon and rectum, 58 e416 (2015) [O1]
DOI 10.1097/dcr.0000000000000407
Co-authors Peter Pockney
2015 Greenop KR, Miller M, Bailey HD, de Klerk NH, Attia J, Kellie SJ, et al., 'Childhood folate, B6, B12, and food group intake and the risk of childhood brain tumors: results from an Australian case¿control study', Cancer Causes and Control, 26 871-879 (2015) [C1]

© 2015, Springer International Publishing Switzerland. Purpose: The etiology of childhood brain tumors (CBT) is poorly understood, but dietary factors could be involved. In this ... [more]

© 2015, Springer International Publishing Switzerland. Purpose: The etiology of childhood brain tumors (CBT) is poorly understood, but dietary factors could be involved. In this case¿control study of CBT, the possible associations of childhood intake of dietary and supplemental folate, vitamin B6, and vitamin B12 with the risk of CBT were investigated, along with various food groups. Methods: Cases diagnosed between 2005 and 2010 were identified from 10 pediatric oncology centers in Australia and controls by nationwide random-digit dialling. For study children of ages 3¿14¿years, diet in the year before diagnosis (or recruitment) was assessed using food frequency questionnaires. Folate intake was adjusted for bioavailability, and dietary micronutrient intake was energy-adjusted. Micronutrients and food groups were analyzed using logistic regression adjusting for relevant confounders. Principal components analysis was conducted to assess food group intake patterns for analysis. Results: Food and micronutrient data were available for 216 cases and 523 controls. Folate intake was associated with a reduced risk of CBT overall (odds ratio for highest tertile vs. lowest: 0.63, 95¿% confidence interval 0.41, 0.97) and particularly low-grade gliomas (odds ratio for highest tertile vs. lowest: 0.52, 95¿% confidence interval 0.29, 0.92). Vitamin B6 and B12 intake was not associated with CBT risk, nor was processed meat. Conclusions: High folate intake during childhood may reduce the risk of CBT. This potentially important finding needs to be corroborated in other studies. If replicated, these results could have important implications for public health recommendations regarding diet during childhood.

DOI 10.1007/s10552-015-0562-z
Citations Scopus - 1Web of Science - 1
2015 Sansanayudh N, Numthavaj P, Muntham D, Yamwong S, McEvoy M, Attia J, et al., 'Prognostic effect of mean platelet volume in patients with coronary artery disease: A systematic review and meta-analysis', Thrombosis and Haemostasis, 114 1299-1309 (2015) [C1]
DOI 10.1160/TH15-04-0280
Citations Scopus - 7Web of Science - 6
Co-authors Mark Mcevoy
2015 Moir-Meyer GL, Pearson JF, Lose F, The ANECSG, Scott RJ, McEvoy M, et al., 'Rare germline copy number deletions of likely functional importance are implicated in endometrial cancer predisposition', Human Genetics, 134 269-278 (2015) [C1]

© 2014, Springer-Verlag Berlin Heidelberg. Endometrial cancer is the most common invasive gynaecological cancer in women, and relatively little is known about inherited risk fact... [more]

© 2014, Springer-Verlag Berlin Heidelberg. Endometrial cancer is the most common invasive gynaecological cancer in women, and relatively little is known about inherited risk factors for this disease. This is the first genome-wide study to explore the role of common and rare germline copy number variants (CNVs) in predisposition to endometrial cancer. CNVs were called from germline DNA of 1,209 endometrioid endometrial cancer cases and 528 cancer-unaffected female controls. Overall CNV load of deletions or DNA gains did not differ significantly between cases and controls (P¿ > ¿0.05), but cases presented with an excess of rare germline deletions overlapping likely functional genomic regions including genes (P¿=¿8¿×¿10 < sup > -10 < /sup > ), CpG islands (P¿=¿1¿×¿10 < sup > -7 < /sup > ) and sno/miRNAs regions (P¿=¿3¿×¿10 < sup > -9 < /sup > ). On average, at least one additional gene and two additional CpG islands were disrupted by rare deletions in cases compared to controls. The most pronounced difference was that over 30 sno/miRNAs were disrupted by rare deletions in cases for every single disruption event in controls. A total of 13 DNA repair genes were disrupted by rare deletions in 19/1,209 cases (1.6¿%) compared to one gene in 1/528 controls (0.2¿%; P¿=¿0.007), and this increased DNA repair gene loss in cases persisted after excluding five individuals carrying CNVs disrupting mismatch repair genes MLH1, MSH2 and MSH6 (P¿=¿0.03). There were 34 miRNA regions deleted in at least one case but not in controls, the most frequent of which encompassed hsa-mir-661 and hsa-mir-203. Our study implicates rare germline deletions of functional and regulatory regions as possible mechanisms conferring endometrial cancer risk, and has identified specific regulatory elements as candidates for further investigation.

DOI 10.1007/s00439-014-1507-4
Citations Scopus - 3Web of Science - 2
Co-authors Liz Holliday, Mark Mcevoy, Rodney Scott
2015 Painter JN, O'Mara TA, Batra J, Cheng T, Lose FA, Dennis J, et al., 'Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk', HUMAN MOLECULAR GENETICS, 24 1478-1492 (2015) [C1]
DOI 10.1093/hmg/ddu552
Citations Scopus - 17Web of Science - 15
Co-authors Mark Mcevoy, Liz Holliday, Rodney Scott
2015 Kelly AG, Attia J, 'Balancing access and quality in comprehensive stroke care', Neurology, 84 1188-1189 (2015) [C3]
DOI 10.1212/WNL.0000000000001405
2015 Hancock DB, Levy JL, Gaddis NC, Glasheen C, Saccone NL, Page GP, et al., 'Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1', Biological Psychiatry, 78 474-484 (2015) [C1]
DOI 10.1016/j.biopsych.2015.01.003
Citations Scopus - 8Web of Science - 8
Co-authors Liz Holliday, Rodney Scott, Mark Mcevoy
2015 Holliday EG, Traylor M, Malik R, Bevan S, Falcone G, Hopewell JC, et al., 'Genetic Overlap Between Diagnostic Subtypes of Ischemic Stroke', STROKE, 46 615-+ (2015) [C1]
DOI 10.1161/STROKEAHA.114.007930
Citations Scopus - 15Web of Science - 13
Co-authors Rodney Scott, Christopher Levi, Christopher Oldmeadow, Liz Holliday, Lisa Lincz
2015 Sapkota Y, Low SK, Attia J, Gordon SD, Henders AK, Holliday EG, et al., 'Association between endometriosis and the interleukin 1A (IL1A) locus.', Human Reproduction, 30 239-248 (2015) [C1]
DOI 10.1093/humrep/deu267
Citations Scopus - 19Web of Science - 18
Co-authors Liz Holliday, Mark Mcevoy, Rodney Scott
2015 Iseme RA, McEvoy M, Kelly B, Agnew L, Attia J, Walker FR, et al., 'Autoantibodies are not predictive markers for the development of depressive symptoms in a population-based cohort of older adults', European Psychiatry, 30 694-700 (2015) [C1]
DOI 10.1016/j.eurpsy.2015.06.006
Citations Scopus - 1Web of Science - 1
Co-authors Mark Mcevoy, Brian Kelly, Christopher Oldmeadow, Rohan Walker
2015 O'Mara TA, Glubb DM, Painter JN, Cheng T, Dennis J, Australian National Endometrial Cancer Study Group (ANECS), et al., 'Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer.', Endocr Relat Cancer, 22 851-861 (2015) [C1]
DOI 10.1530/ERC-15-0319
Citations Scopus - 5Web of Science - 5
Co-authors Liz Holliday, Rodney Scott, Mark Mcevoy
2015 Chiong FJK, Loewenthal M, Boyle M, Attia J, 'Serum sickness-like reaction after influenza vaccination.', BMJ Case Rep, 2015 (2015) [C3]
DOI 10.1136/bcr-2015-211917
Citations Scopus - 1
2015 Thomas LC, Rivett DA, Attia JR, Levi C, 'Risk factors and clinical presentation of cervical arterial dissection: Preliminary results of a prospective case-control study', Journal of Orthopaedic and Sports Physical Therapy, 45 503-511 (2015) [C1]

Copyright ©2015 Journal of Orthopaedic &amp; Sports Physical Therapy®. All rights reserved. STUDY DESIGN: Cross-sectional case-control study. OBJECTIVES: To identify risk fact... [more]

Copyright ©2015 Journal of Orthopaedic & Sports Physical Therapy®. All rights reserved. STUDY DESIGN: Cross-sectional case-control study. OBJECTIVES: To identify risk factors and clinical presentation of individuals with cervical arterial dissection. BACKGROUND: Cervical arterial dissection is a common cause of stroke in young people and has in rare cases been associated with cervical manipulative therapy. The mechanism is considered to involve pre-existing arterial susceptibility and a precipitating event, such as minor trauma. Identification of individuals at risk or early recognition of a dissection in progress could help expedite medical intervention and avoid inappropriate treatment. METHODS: Participants were individuals 55 years of age or younger from the Hunter region of New South Wales, Australia with radiologically confirmed vertebral or internal carotid artery dissection and an age- and sex-matched comparison group. Participants were interviewed about risk factors, preceding events, and clinical features of their stroke. Physical examination of joint mobility and soft tissue compliance was undertaken. RESULTS: Twenty-four participants with cervical arterial dissection and 21 matched comparisons with ischemic stroke but not dissection were included in the study. Seventeen (71%) of the 24 participants with dissection reported a recent history of minor mechanical neck trauma or strain, with 4 of these 17 reporting recent neck manipulative therapy treatment. Cardiovascular risk factors were uncommon, with the exception of diagnosed migraine. Among the participants with dissection, 67% reported transient ischemic features in the month prior to their admission for dissection. CONCLUSION: Recent minor mechanical trauma or strain to the head or neck appears to be associated with cervical arterial dissection. General cardiovascular risk factors, with the exception of migraine, were not important risk factors for dissection in this cohort. Preceding transient neurological symptoms appear to occur commonly and may assist in the identification of this serious pathology.

DOI 10.2519/jospt.2015.5877
Citations Scopus - 6Web of Science - 4
Co-authors Lucy Thomas, Darren Rivett, Christopher Levi
2015 Kodur S, Ahmad W, Heittarachi M, Reeves G, Attia J, Barker D, Collins N, 'Influence of age on outcome in patients with pulmonary arterial hypertension', Heart Lung and Circulation, 24 719-723 (2015) [C1]

© 2015 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Background: The development of ... [more]

© 2015 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Background: The development of effective orally administered medical therapy for pulmonary arterial hypertension (PAH) has made a significant impact on outcome in patients with PAH. Identification of patient groups likely to derive optimal benefit is important, given cost and potential side effects; the clinical effectiveness of these therapies in older patients with PAH is unclear as the presence of co-morbidity may limit benefits of therapy. Aims: We evaluated the epidemiology of PAH in a contemporary cohort to assess the influence of age on long-term outcome using PAH-specific therapies. Results: A total of 119 patients (88% female; mean age 65±12 years) were reviewed, comprising 52% with underlying connective tissue disease. Bosentan was the PAH specific agent most frequently used. The baseline 6MWT distance in the entire cohort was 304m with age associated with a significant decline in 6MWT. Conclusions: In a large cohort of patients treated with PAH-specific therapies, patients less than 55 years of age showed improvement in 6MWT with older patients demonstrating stabilisation or decline.

DOI 10.1016/j.hlc.2015.01.012
Citations Scopus - 2Web of Science - 2
2015 Inder KJ, Hussain R, Allen J, Brew B, Lewin TJ, Attia J, Kelly BJ, 'Factors associated with personal hopefulness in older rural and urban residents of New South Wales', Advances in Mental Health, 13 43-57 (2015) [C1]

© 2015, Taylor &amp; Francis. Background: As research focuses on the concept of resilience, evidence suggests that greater levels of personal hope may have a mitigating effect ... [more]

© 2015, Taylor & Francis. Background: As research focuses on the concept of resilience, evidence suggests that greater levels of personal hope may have a mitigating effect on the mental health impact of adversity. In view of the adversity affecting rural communities, a better understanding of factors influencing personal hope may help identify foci for mental health promotion and mental illness prevention research and interventions. Aim: To explore the relationship between demographic, socioeconomic and mental health factors and personal hopefulness, including the influence of locality and remoteness. Method: Using data from two community-based longitudinal cohorts from New SouthWales ¿ one urban and one rural ¿ we analysed cross-sectional relationships between a range of factors and personal hopefulness using logistic regression techniques, as part of a common follow-up. Personal hopefulness was measured using a 12-item scale and scores were categorised as low ( < 2.5), medium (2.5¿3.4) and high (=3.5). Results: Of 2774 participants (53% female, mean age 69.1 years [SD 7.3, range 58¿91 years], 36% living outside metropolitan areas) 32% had low, 51% had medium and 17% had high personal hopefulness scores. Several factors displayed univariate associations with personal hopefulness. In the multivariate model, five factors were independently associated with lower personal hopef ulness: being older, having lower perceived prosperity, less frequent socialisation, experiencing high psychological distress or psychological impairment. Hopefulness was not associated with geographical location. Conclusion: The impact of current psychological distress and aspects of adversity on personal hopefulness over time should be further investigated in longitudinal research. Personal hopefulness did not differ across geographical location.

DOI 10.1080/18374905.2015.1039186
Citations Scopus - 1
Co-authors Brian Kelly, Terry Lewin, Kerry Inder
2014 Vashum KP, McEvoy M, Milton AH, McElduff P, Hure A, Byles J, Attia J, 'Dietary zinc is associated with a lower incidence of depression: findings from two Australian cohorts.', J Affect Disord, 166 249-257 (2014) [C1]
DOI 10.1016/j.jad.2014.05.016
Citations Scopus - 30Web of Science - 29
Co-authors Alexis Hure, Milton Hasnat, Mark Mcevoy, Julie Byles, Patrick Mcelduff
2014 Oldmeadow C, Mossman D, Evans T-J, Holliday EG, Tooney PA, Cairns MJ, et al., 'Combined analysis of exon splicing and genome wide polymorphism data predict schizophrenia risk loci.', J Psychiatr Res, 52 44-49 (2014) [C1]
DOI 10.1016/j.jpsychires.2014.01.011
Citations Scopus - 7Web of Science - 7
Co-authors Christopher Oldmeadow, Liz Holliday, Rodney Scott, Murray Cairns, Paul Tooney
2014 Paul CL, Levi CR, D'Este CA, Parsons MW, Bladin CF, Lindley RI, et al., 'Thrombolysis ImPlementation in Stroke (TIPS): Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice - protocol for a cluster randomised controlled trial in acute stroke care', Implementation Science, 9 (2014) [C3]

Background: Stroke is a leading cause of death and disability internationally. One of the three effective interventions in the acute phase of stroke care is thrombolytic therapy w... [more]

Background: Stroke is a leading cause of death and disability internationally. One of the three effective interventions in the acute phase of stroke care is thrombolytic therapy with tissue plasminogen activator (tPA), if given within 4.5 hours of onset to appropriate cases of ischaemic stroke.Objectives: To test the effectiveness of a multi-component multidisciplinary collaborative approach compared to usual care as a strategy for increasing thrombolysis rates for all stroke patients at intervention hospitals, while maintaining accepted benchmarks for low rates of intracranial haemorrhage and high rates of functional outcomes for both groups at three months.Methods and design: A cluster randomised controlled trial of 20 hospitals across 3 Australian states with 2 groups: multi- component multidisciplinary collaborative intervention as the experimental group and usual care as the control group. The intervention is based on behavioural theory and analysis of the steps, roles and barriers relating to rapid assessment for thrombolysis eligibility; it involves a comprehensive range of strategies addressing individual-level and system-level change at each site. The primary outcome is the difference in tPA rates between the two groups post-intervention. The secondary outcome is the proportion of tPA treated patients in both groups with good functional outcomes (modified Rankin Score (mRS < 2) and the proportion with intracranial haemorrhage (mRS =2), compared to international benchmarks.Discussion: TIPS will trial a comprehensive, multi-component and multidisciplinary collaborative approach to improving thrombolysis rates at multiple sites. The trial has the potential to identify methods for optimal care which can be implemented for stroke patients during the acute phase. Study findings will include barriers and solutions to effective thrombolysis implementation and trial outcomes will be published whether significant or not.Trial registration: Australian New Zealand Clinical Trials Registry: ACTRN12613000939796. © 2014 Paul et al.; licensee BioMed Central Ltd.

DOI 10.1186/1748-5908-9-38
Citations Scopus - 5Web of Science - 4
Co-authors Chris Paul, Mark Parsons, Catherine Deste, Rob Sanson-Fisher, Frans Henskens, Christopher Levi
2014 Squance ML, Guest M, Reeves G, Attia J, Bridgman H, 'Exploring lifetime occupational exposure and SLE flare: a patient-focussed pilot study.', Lupus Science & Medicine, 1 1-9 (2014) [C1]
DOI 10.1136/lupus-2014-000023
Citations Scopus - 2
2014 Traylor M, Mäkelä K-M, Kilarski LL, Holliday EG, Devan WJ, Nalls MA, et al., 'A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach.', PLoS Genet, 10 e1004469 (2014) [C1]
DOI 10.1371/journal.pgen.1004469
Citations Scopus - 23Web of Science - 22
Co-authors Liz Holliday, Christopher Levi
2014 Sotgia S, Zinellu A, Mangoni AA, Pintus G, Attia J, Carru C, McEvoy M, 'Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults', PLoS ONE, 9 (2014) [C1]

Background: Despite the increasing interest towards the biological role of L-ergothioneine, little is known about the serum concentrations of this unusual aminothiol in older adul... [more]

Background: Despite the increasing interest towards the biological role of L-ergothioneine, little is known about the serum concentrations of this unusual aminothiol in older adults. We addressed this issue in a representative sample of community-dwelling middle-aged and older adults. Methods: Body mass index, estimated glomerular filtration rate, serum concentrations of L-ergothioneine, taurine, homocysteine, cysteine, glutathione, cysteinylglycine, and glutamylcysteine were evaluated in 439 subjects (age 55-85 years) randomly selected from the Hunter Community Study. Results: Median L-ergothioneine concentration in the entire cohort was 1.01 IQR 0.78-1.33 µmol/L. Concentrations were not affected by gender (P = 0.41) or by presence of chronic medical conditions (P = 0.15). By considering only healthy subjects, we defined a reference interval for L-ergothioneine serum concentrations from 0.36 (90% CI 0.31-0.44) to 3.08 (90% CI 2.45-3.76) µmol/L. Using stepwise multiple linear regression analysis L-ergothioneine was negatively correlated with age (rpartial = 20.15; P = 0.0018) and with glutamylcysteine concentrations (rpartial = 20.13; P = 0.0063). Conclusions: A thorough analysis of serum L-ergothioneine concentrations was performed in a large group of community-dwelling middle-aged and older adults. Reference intervals were established. Age and glutamylcysteine were independently negatively associated with L-ergothioneine serum concentration. © 2014 Sotgia et al.

DOI 10.1371/journal.pone.0084918
Citations Scopus - 9Web of Science - 9
Co-authors Mark Mcevoy
2014 Vashum KP, McEvoy M, Milton AH, Islam MR, Hancock S, Attia J, 'Is serum zinc associated with pancreatic beta cell function and insulin sensitivity in pre-diabetic and normal individuals? Findings from the hunter community study', PLoS ONE, 9 (2014) [C1]

Aim: To determine if there is a difference in serum zinc concentration between normoglycaemic, pre-diabetic and type-2 diabetic groups and if this is associated with pancreatic be... [more]

Aim: To determine if there is a difference in serum zinc concentration between normoglycaemic, pre-diabetic and type-2 diabetic groups and if this is associated with pancreatic beta cell function and insulin sensitivity in the former 2 groups. Method: Cross sectional study of a random sample of older community-dwelling men and women in Newcastle, New South Wales, Australia. Beta cell function, insulin sensitivity and insulin resistance were calculated for normoglycaemic and prediabetes participants using the Homeostasis Model Assessment (HOMA-2) calculator. Result: A total of 452 participants were recruited for this study. Approximately 33% (N = 149) had diabetes, 33% (N = 151) had prediabetes and 34% (N = 152) were normoglycaemic. Homeostasis Model Assessment (HOMA) parameters were found to be significantly different between normoglycaemic and prediabetes groups (p < 0.001). In adjusted linear regression, higher serum zinc concentration was associated with increased insulin sensitivity (p = 0.01) in the prediabetic group. There was also a significant association between smoking and worse insulin sensitivity. Conclusion: Higher serum zinc concentration is associated with increased insulin sensitivity. Longitudinal studies are required to determine if low serum zinc concentration plays a role in progression from pre-diabetes to diabetes. © 2014 Vashum et al.

DOI 10.1371/journal.pone.0083944
Citations Scopus - 11Web of Science - 10
Co-authors Mark Mcevoy, Milton Hasnat
2014 Evans T-J, Milne E, Anderson D, de Klerk NH, Jamieson SE, Talseth-Palmer BA, et al., 'Confirmation of childhood acute lymphoblastic leukemia variants, ARID5B and IKZF1, and interaction with parental environmental exposures.', PLoS One, 9 e110255 (2014) [C1]
DOI 10.1371/journal.pone.0110255
Citations Scopus - 6Web of Science - 7
Co-authors Nikola Bowden, Rodney Scott, Bente Talseth-Palmer, Liz Holliday
2014 White JH, Patterson K, Jordan L-A, Magin P, Attia J, Sturm JW, 'The experience of urinary incontinence in stroke survivors: A follow-up qualitative study', CANADIAN JOURNAL OF OCCUPATIONAL THERAPY-REVUE CANADIENNE D ERGOTHERAPIE, 81 124-134 (2014) [C1]
DOI 10.1177/0008417414527257
Citations Scopus - 4Web of Science - 4
Co-authors Parker Magin
2014 White J, Dickson A, Magin P, Tapley A, Attia J, Sturm J, Carter G, 'Exploring the experience of psychological morbidity and service access in community dwelling stroke survivors: a follow-up study', DISABILITY AND REHABILITATION, 36 1600-1607 (2014) [C1]
DOI 10.3109/09638288.2013.859748
Citations Web of Science - 2
Co-authors Gregory Carter, Parker Magin
2014 Lai JS, Hiles S, Bisquera A, Hure AJ, McEvoy M, Attia J, 'A systematic review and meta-analysis of dietary patterns and depression in community-dwelling adults', AMERICAN JOURNAL OF CLINICAL NUTRITION, 99 181-197 (2014) [C1]
DOI 10.3945/ajcn.113.069880
Citations Scopus - 130Web of Science - 118
Co-authors Alexis Hure, Sarah Hiles, Mark Mcevoy
2014 Holliday EG, Attia J, Hancock S, Koloski N, McEvoy M, Peel R, et al., 'Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome', American Journal of Gastroenterology, 109 770-772 (2014) [C1]
DOI 10.1038/ajg.2014.56
Citations Scopus - 6Web of Science - 8
Co-authors Roseanne Peel, Nicholas Talley, Mark Mcevoy, Liz Holliday, Rodney Scott
2014 Ho YM, Smith SR, Pockney P, Lim P, Attia J, 'A Meta-analysis on the Effect of Sham Feeding Following Colectomy: Should Gum Chewing Be Included in Enhanced Recovery After Surgery Protocols?', DISEASES OF THE COLON & RECTUM, 57 115-126 (2014) [C1]
DOI 10.1097/DCR.0b013e3182a665be
Citations Scopus - 19Web of Science - 18
Co-authors Peter Pockney
2014 Robertson J, Pearson S-A, Attia JR, 'How well do NSW hospital data identify cases of heart failure?', MEDICAL JOURNAL OF AUSTRALIA, 200 25-25 (2014) [C3]
DOI 10.5694/mja13.10207
Citations Scopus - 3Web of Science - 3
2014 Iseme RA, McEvoy M, Kelly B, Agnew L, Attia J, Walker FR, 'Autoantibodies and depression. Evidence for a causal link?', Neuroscience and Biobehavioral Reviews, 40 62-79 (2014) [C1]

Depression is a leading contributor to the global burden of diseases. Despite advances in research, challenges still exist in managing this disorder. Sufferers of autoimmune disea... [more]

Depression is a leading contributor to the global burden of diseases. Despite advances in research, challenges still exist in managing this disorder. Sufferers of autoimmune diseases are often observed to suffer from depression more often than healthy individuals, an association that cannot be completely accounted for by the impact of the disease on the individual. An association between autoimmunity and depressive symptoms also appears to exist in populations with subclinical symptoms. Moreover, researchers have successfully developed murine models illustrating the ability of autoantibodies to induce depressive-like symptoms. This paper will provide an overview of the association between autoantibodies and occurrence of depressive symptoms. Though current evidence appears to support a role for autoantibodies in the pathogenesis of depression, the majority of studies have examined this relationship cross-sectionally, therefore failing to establish a temporal association. Nonetheless, this novel theory meshes with older and newer neurochemical theories of depression. A better understanding of the immuno-pathogenesis underlying depression presents opportunities for more targeted treatment approaches and more timely and appropriate measures of detection. © 2014 Elsevier Ltd.

DOI 10.1016/j.neubiorev.2014.01.008
Citations Scopus - 17Web of Science - 17
Co-authors Mark Mcevoy, Rohan Walker, Brian Kelly
2014 Quilty S, Valler D, Attia J, 'Rural general physicians: Improving access and reducing costs of health care in the bush', Australian Health Review, 38 420-424 (2014) [C1]

Objective To assess the effectiveness of the introduction of a trainee specialist physician into the workforce mix of a rural hospital in the Northern Territory. Methods A retrosp... [more]

Objective To assess the effectiveness of the introduction of a trainee specialist physician into the workforce mix of a rural hospital in the Northern Territory. Methods A retrospective review comparing clinical and non-clinical outcomes during two corresponding 6-month periods in 2011 and 2012, before and after a FRACP Trainee in General and Acute Care Medicine commenced employment in the hospital. Results There was a significant reduction of 18% in total length of stay of admitted adult patients, with a 23% reduction of inter-hospital transfers and a 43% reduction of total aeromedical evacuations after the introduction of the trainee specialist. Although there was a 9% increase in patients presenting to the emergency department, there was a 9% reduction in total adult admissions. There was no change in the overall in-patient mortality rate; however, there was a significant change in the location of death, with an increase in patients dying in Katherine Hospital and a reciprocal decrease in death rate in those who had been transferred to Royal Darwin Hospital after the arrival of the trainee Conclusions The addition of an Advanced Trainee in General Medicine led to a significant change in the capacity of the hospital to care for unwell and complex patients. The role of the hospital in the care of dying patients was redefined and allowed many more people to pass away closer to their community and families. There were considerable savings at Katherine Hospital in terms of reduced bed pressure, reduced hospital bypass behaviour and reduced inter-hospital transfers, and these translated into significant benefits for the tertiary referral hospital in Darwin. A rural general physician can greatly value add to the capacity of a rural hospital and is a highly effective mechanism for reducing the disparities in healthcare access for rural and Indigenous patients. What is known about this topic? There is little research about the clinical and non-clinical impact of the addition of general speciality clinicians into the workforce of rural hospitals. Although there are several regional hospitals in Australia that have general specialists (i.e. emergency department physicians, general physicians and surgeons) and sub-specialists where the volume of patients is adequate to support such a workforce, there has been no published assessment of the impact of the addition of such speciality services. What does this paper add? This paper provides evidence of the cost-effectiveness of the addition of a specialist general physician to the workforce of a remote hospital servicing a large Indigenous population with very high burdens of acute and chronic illnesses in the Northern Territory. The paper demonstrates the potential to significantly add capacity to a rural or regional hospital by moving general speciality care to the hospital rather than, or in addition to, providing other methods of speciality and sub-speciality health care delivery. What are the implications for practitioners? The implications of this paper are that a significantly cost-effective means of addressing health care delivery to rural and remote populations is through the addition of appropriately trained general specialists such as emergency department physicians, general physicians and general surgeons. The implications extend to broader workforce development policies for education providers, speciality colleges and state and federal governments. © AHHA 2014.

DOI 10.1071/AH13197
Citations Scopus - 2Web of Science - 2
2014 Wang JJ, Buitendijk GHS, Rochtchina E, Lee KE, Klein BEK, Van Duijn CM, et al., 'Genetic susceptibility, dietary antioxidants, and long-term incidence of age-related macular degeneration in two populations', Ophthalmology, 121 667-675 (2014) [C1]

Objective To examine effect modification between genetic susceptibility to age-related macular degeneration (AMD) and dietary antioxidant or fish consumption on AMD risk. Design P... [more]

Objective To examine effect modification between genetic susceptibility to age-related macular degeneration (AMD) and dietary antioxidant or fish consumption on AMD risk. Design Pooled data analysis of population-based cohorts. Participants Participants from the Blue Mountains Eye Study (BMES) and Rotterdam Study (RS). Methods Dietary intakes of antioxidants (lutein/zeaxanthin [LZ], ß-carotene, and vitamin C), long-chain omega-3 polyunsaturated fatty acids, and zinc were estimated from food frequency questionnaires. The AMD genetic risk was classified according to the number of risk alleles of CFH (rs1061170) or ARMS2 (rs10490924) as low (no or 1 risk allele) or high (=2 risk alleles). Interactions between dietary intake and genetic risk levels were assessed. Associations between dietary intake and AMD risk were assessed comparing the highest with the 2 lower intake tertiles by genetic risk subgroups using discrete logistic regression, conducted in each study separately and then using pooled data. Participants without AMD lesions at any visit were controls. We adjusted for age and sex in analyses of each cohort sample and for smoking status and study site in pooled-data analyses. Main Outcome Measures All 15-year incident late AMD cases were confirmed by chief investigators of the Beaver Dam Eye Study, BMES, and RS. Intergrader reproducibility was assessed in an early AMD subsample, with 86.4% agreement between BMES and RS graders, allowing for a 1-step difference on a 5-step AMD severity scale. Results In pooled data analyses, we found significant interaction between AMD genetic risk status and LZ intake (P = 0.0009) but nonsignificant interactions between genetic risk status and weekly fish consumption (P = 0.05) for risk of any AMD. Among participants with high genetic risk, the highest intake tertile of LZ was associated with a > 20% reduced risk of early AMD, and weekly consumption of fish was associated with a 40% reduced risk of late AMD. No similar association was evident among participants with low genetic risk. No interaction was detected between ß-carotene or vitamin C and genetic risk status. Conclusions Protection against AMD from greater LZ and fish consumption in persons with high genetic risk based on 2 major AMD genes raises the possibility of personalized preventive interventions. ©2014 by the American Academy of Ophthalmology.

DOI 10.1016/j.ophtha.2013.10.017
Citations Scopus - 25Web of Science - 27
Co-authors Wayne Smith, Liz Holliday
2014 Greenop KR, de Klerk NH, Bower C, Milne E, Miller M, Scott RJ, et al., 'Maternal Dietary Intake of Folate and Vitamins B6 and B12 During Pregnancy and Risk of Childhood Brain Tumors', Nutrition and Cancer, (2014) [C1]

Childhood brain tumors (CBT) are the second most common childhood cancers, yet their etiology is largely unknown. We investigated whether maternal gestational intake of folate and... [more]

Childhood brain tumors (CBT) are the second most common childhood cancers, yet their etiology is largely unknown. We investigated whether maternal gestational intake of folate and vitamins B6 and B12 was associated with CBT risk in a nationwide case-control study conducted 2005-2010. Case children 0-14 years were recruited from all 10 Australian pediatric oncology centers. Control children were recruited by national random digit dialing, frequency matched to cases on age, sex, and state of residence. Dietary intake was ascertained using food frequency questionnaires and adjusted for total energy intake. Data from 293 case and 726 control mothers were analyzed using unconditional logistic regression. The odds ratio (OR) for the highest versus lowest tertile of folate intake was 0.70 [95% confidence interval (CI): 0.48, 1.02]. The ORs appeared lower in mothers who drank alcohol during pregnancy (OR = 0.45, 95% CI: 0.22, 0.93), mothers who took folic acid (OR = 0.67, 95% CI: 0.42, 1.06) or B6/B12 supplements (OR = 0.51, 95% CI: 0.25, 1.06) and in children younger than 5 years (OR = 0.50, 95% CI: 0.27, 0.93). These findings are consistent with folate's crucial role in maintenance of genomic integrity and DNA methylation. Dietary intake of B6 and B12 was not associated with risk of CBT. © 2014 Copyright © Taylor & Francis Group, LLC.

DOI 10.1080/01635581.2014.916326
Citations Scopus - 14Web of Science - 12
Co-authors Rodney Scott
2014 Thakkinstian A, Chailurkit L, Warodomwichit D, Ratanachaiwong W, Yamwong S, Chanprasertyothin S, et al., 'Causal relationship between body mass index and fetuin-A level in the asian population: A bidirectional mendelian randomization study', Clinical Endocrinology, 81 197-203 (2014) [C1]

Objective Fetuin-A is associated with body mass index (BMI) as well as components of the metabolic syndrome. However, it is unclear if fetuin-A affects BMI or the other way around... [more]

Objective Fetuin-A is associated with body mass index (BMI) as well as components of the metabolic syndrome. However, it is unclear if fetuin-A affects BMI or the other way around. We therefore assessed the causal association between fetuin-A and BMI or vice versa, utilizing a bidirectional Mendelian randomization approach. Design and Methods This was a study of 2558 subjects from the Electricity Generating Authority of Thailand (EGAT) cohort. Two polymorphisms, that is, rs2248690 in the alpha2-Hereman-Schmid glycoprotein (AHSG) gene and rs9939609 in the fat mass and obesity-Associated (FTO) gene were genotyped. Bidirectional causal models were constructed using a two-stage least-square instrumental variable (IV) regression. First, rs2248690 locus was used as the instrumental variable for the effect of circulating fetuin-A on BMI, and then, the FTO rs9939609 locus was used as t he instrumental variable for the effect of BMI on circulating fetuin-A. Results Among the 2558 subjects, the prevalence of the minor AHSG (T) and FTO (A) alleles was 17·9% and 22·1%, respectively. The AHSG rs2248690 locus was highly related to serum fetuin-A levels (P < 0·001). Likewise, the FTO rs9939609 locus and BMI were highly associated (P < 0·001). Mendelian randomization analyses showed that circulating fetuin-A, instrumented by the AHSG rs2248690 locus, was associated with BMI (coefficient = 2·26; 95% CI: 0·39, 4·12). In contrast, BMI, instrumented by the FTO rs9939609 locus, was not associated with circulating fetuin-A (coefficient = 0·0007; 95% CI: -0·0242, 0·0256). Conclusion Our findings suggest a causal association leading from circulating fetuin-A to BMI. There was no evidence of reverse causality from BMI to fetuin-A. © 2013 John Wiley & Sons Ltd.

DOI 10.1111/cen.12303
Citations Scopus - 13Web of Science - 10
2014 Joshy G, Korda RJ, Attia J, Liu B, Bauman AE, Banks E, 'Body mass index and incident hospitalisation for cardiovascular disease in 158 546 participants from the 45 and Up Study', International Journal of Obesity, 38 848-856 (2014) [C1]

Objective: To investigate the relationship between fine gradations in body mass index (BMI) and risk of hospitalisation for different types of cardiovascular disease (CVD). Design... [more]

Objective: To investigate the relationship between fine gradations in body mass index (BMI) and risk of hospitalisation for different types of cardiovascular disease (CVD). Design, Subjects and Methods: The 45 and Up Study is a large-scale Australian cohort study initiated in 2006. Self-reported data from 158 546 individuals with no history of CVD were linked prospectively to hospitalisation and mortality data. Hazard ratios (HRs) of incident hospitalisation for specific CVD diagnoses in relation to baseline BMI categories were estimated using Cox regression, adjusting for age, sex, region of residence, income, education, smoking, alcohol intake and health insurance status. Results: There were 9594 incident CVD admissions over 583 100 person-years among people with BMI=20 kg m -2 , including 3096 for ischaemic heart disease (IHD), 1373 for stroke, 411 for peripheral vascular disease (PVD) and 320 for heart failure. The adjusted HR of hospitalisation for all CVD diagnoses combined increased significantly with increasing BMI (P(trend) < 0.0001)). The HR of IHD hospitalisation increased by 23% (95% confidence interval (95% CI): 18-27%) per 5 kg m -2 increase in BMI (compared to BMI 20.0-22.49 kg m -2 , HR (95% CI) for BMI categories were: 22.5-24.99=1.25 (1.08-1.44); 25-27.49=1.43 (1.24-1.65); 27.5-29.99=1.64 (1.42-1.90); 30-32.49=1.63 (1.39-1.91) and 32.5-50=2.10 (1.79-2.45)). The risk of hospitalisation for heart failure showed a significant, but nonlinear, increase with increasing BMI. No significant increase was seen with above-normal BMI for stroke or PVD. For other specific classifications of CVD, HRs of hospitalisation increased significantly with increasing BMI for: hypertension; angina; acute myocardial infarction; chronic IHD; pulmonary embolism; non-rheumatic aortic valve disorders; atrioventricular and left bundle-branch block; atrial fibrillation and flutter; aortic aneurysm; and phlebitis and thrombophlebitis. Conclusion: The risk of hospitalisation for a wide range of CVD subtypes increases with relatively fine increments in BMI. Obesity prevention strategies are likely to benefit from focusing on bringing down the mean BMI at the population level, in addition to targeting those with a high BMI. © 2014 Macmillan Publishers Limited All rights reserved.

DOI 10.1038/ijo.2013.192
Citations Scopus - 18Web of Science - 16
2014 De Vivo I, Prescott J, Setiawan VW, Olson SH, Wentzensen N, Attia J, et al., 'Genome-wide association study of endometrial cancer in E2C2', HUMAN GENETICS, 133 211-224 (2014) [C1]
DOI 10.1007/s00439-013-1369-1
Citations Scopus - 18Web of Science - 19
Co-authors Liz Holliday, Mark Mcevoy, Rodney Scott
2014 Williams FMK, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, et al., 'Ischemic stroke is associated with the ABO locus: The EuroCLOT study (vol 73, pg 16, 2013)', ANNALS OF NEUROLOGY, 75 166-167 (2014)
DOI 10.1002/ana.24105
Co-authors Liz Holliday, Christopher Levi, Rodney Scott
2014 Woratanarat P, Thaveeratitharm C, Woratanarat T, Angsanuntsukh C, Attia J, Thakkinstian A, 'Meta-analysis of hypercoagulability genetic polymorphisms in perthes disease', Journal of Orthopaedic Research, 32 1-7 (2014) [C1]

Perthes disease is an osteonecrosis of the femoral epiphysis with unclear etiology. This study aimed to systematically review the association between genetic determinants of hyper... [more]

Perthes disease is an osteonecrosis of the femoral epiphysis with unclear etiology. This study aimed to systematically review the association between genetic determinants of hypercoagulability (Factor V Leiden, prothrombin II, and methylenetetrahydrofolate reductase; MTHFR) and Perthes disease. PubMed and Scopus searched from inception to January 2012, data extraction and quality assessment were performed. The odds ratio (OR) for the allele effect was pooled, and heterogeneity and publication bias were assessed. Twelve case-control studies met inclusion criteria and had sufficient data for extraction. There were 824 cases and 2,033 controls with a mean age range of 6.1-14.7 years. The prevalence of the minor allele in controls was 0.015 (95% confidence interval (CI): 0.008, 0.023), 0.012 (95% CI: 0.008, 0.017), and 0.105 (95% CI: 0.044, 0.167) for factor V Leiden, prothrombin II, and MTHFR, respectively. The factor V Leiden allele increased the risk of Perthes with a pooled OR of 3.10 (95% CI: 1.68, 5.72), while prothrombin II and MTHFR had non-significantly pooled OR 1.48 (95% CI: 0.71, 3.08), and 0.97 (95% CI: 0.72, 1.30), respectively. The factor V Leiden mutation is significantly related to Perthes disease, and its screening in at-risk children might be useful in the future. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

DOI 10.1002/jor.22473
Citations Scopus - 12Web of Science - 10
2014 Sansanayudh N, Anothaisintawee T, Muntham D, McEvoy M, Attia J, Thakkinstian A, 'Mean platelet volume and coronary artery disease: A systematic review and meta-analysis', International Journal of Cardiology, 175 433-440 (2014)

Background Platelets with high hemostatic activity play an important role in the pathophysiology of coronary artery disease(CAD) and mean platelet volume(MPV) has been proposed as... [more]

Background Platelets with high hemostatic activity play an important role in the pathophysiology of coronary artery disease(CAD) and mean platelet volume(MPV) has been proposed as an indicator of platelet reactivity. Thus, MPV may emerge as a potential marker of CAD risk. The aim of this study was to conduct a systematic review and meta-analysis comparing mean difference in MPV between patients with CAD and controls and pooling the odds ratio of CAD in those with high versus low MPV. Methods Medline and Scopus databases were searched up to 12 March 2013. All observational studies that considered MPV as a study's factor and measured CAD as an outcome were included. Two reviewers independently selected the studies and extracted the data. Results Forty studies were included in this meta-analysis. The MPV was significantly larger in patients with CAD than controls with the unstandardized mean difference of 0.70 fL (95% CI: 0.55, 0.85). The unstandardized mean difference of MPV in patients with acute coronary event and in patients with chronic stable angina was 0.84 fL (95% CI: 0.63, 1.04) and 0.46 fL (95% CI: 0.11, 0.81) respectively. Patients with larger MPV (= 7.3 fL) also had a greater odds of having CAD than patients with smaller MPV with a pooled odds ratio of 2.28 (95% CI: 1.46, 3.58). Conclusion Larger MPV was associated with CAD. Thus, it might be helpful in risk stratification, or improvement of risk prediction if combining it with other risk factors in risk prediction models. © 2014 Elsevier Ireland Ltd. All rights reserved.

DOI 10.1016/j.ijcard.2014.06.028
Citations Scopus - 39
Co-authors Mark Mcevoy
2014 Handley TE, Kay-Lambkin FJ, Inder KJ, Attia JR, Lewin TJ, Kelly BJ, 'Feasibility of internet-delivered mental health treatments for rural populations', Social Psychiatry and Psychiatric Epidemiology, 49 275-282 (2014) [C1]

Purpose: Rural populations face numerous barriers to mental health care. Although internet-delivered mental health treatments may offer an accessible and cost-effective answer to ... [more]

Purpose: Rural populations face numerous barriers to mental health care. Although internet-delivered mental health treatments may offer an accessible and cost-effective answer to these barriers, there has been little evaluation of the feasibility of this approach among rural communities. Methods: Data were obtained from a random rural community sample through the third wave of the Australian Rural Mental Health Study. Attitudes towards internet-delivered mental health treatments and availability of internet access were explored. Data were analysed to identify sub-groups in whom internet-delivered treatments may be usefully targeted. Results: Twelve hundred and forty-six participants completed the survey (mean age 59 years, 61 % females, 22 % from remote areas). Overall, 75 % had internet access and 20 % would consider using internet-based interventions, with 18 % meeting both of these feasibility criteria. Logistic regression revealed feasibility for internet-delivered mental health treatment was associated with younger age, male gender, being a carer, and a 12-month mental health problem. Participants who had used internet-delivered services in the past were significantly more likely to endorse these treatments as acceptable. Conclusions: Ther e is considerable potential for internet-delivered treatments to increase service accessibility to some sub-groups, particularly among people with mental health problems who are not currently seeking help. Resistance to internet treatments appears to be largely attitudinal, suggesting that enhancing community education and familiarity with such programs may be effective in improving perceptions and ultimately access. © 2013 Springer-Verlag Berlin Heidelberg.

DOI 10.1007/s00127-013-0708-9
Citations Scopus - 5Web of Science - 5
Co-authors Kerry Inder, Brian Kelly, Frances Kaylambkin, Terry Lewin
2014 Greenop KR, Peters S, Bailey HD, Fritschi L, Attia J, Scott RJ, et al., 'Exposure to pesticides and the risk of childhood brain tumors (vol 24, pg 1269, 2013)', CANCER CAUSES & CONTROL, 25 1239-1240 (2014) [O1]
DOI 10.1007/s10552-014-0418-y
Co-authors Rodney Scott
2014 Greenop KR, Miller M, Attia J, Ashton LJ, Cohn R, Armstrong BK, Milne E, 'Maternal consumption of coffee and tea during pregnancy and risk of childhood brain tumors: results from an Australian case-control study', Cancer Causes & Control, (2014) [C1]

Purpose The causes of childhood brain tumors (CBT) are largely unknown, but gestational diet may influence this risk. The aim of this analysis was to investigate whether maternal ... [more]

Purpose The causes of childhood brain tumors (CBT) are largely unknown, but gestational diet may influence this risk. The aim of this analysis was to investigate whether maternal coffee or tea consumption during pregnancy was associated with the risk of CBT. Methods The Australian Study of the Causes of Childhood Brain Tumours was a population-based, Australian case-control study conducted between 2005 and 2010. Case children were recruited from 10 pediatric oncology centers and control children by nationwide random-digit dialing, frequency matched to cases on the basis of age, sex and state of residence. Coffee and tea intake were assessed using a food frequency questionnaire. Results Data on coffee and tea consumption during pregnancy were available from 293 case mothers and 726 control mothers. Odds ratios (ORs) and confidence intervals (CIs) were calculated using multivariable unconditional logistic regression. There was little evidence of an association between gestational consumption of any coffee (OR 1.23, 95 % CI 0.92, 1.64) or tea (OR 1.00, 95 % CI 0.74, 1.36) and CBT risk. Among children aged under 5 years, the OR for any coffee consumption during pregnancy was 1.76 (95 % CI 1.09, 2.84) and for =2 cups per day during pregnancy was 2.52 (95 % CI 1.26, 5.04). There was little evidence that associations with coffee or tea intake differed by parental smoking status. Conclusions These results suggest a positive association between coffee intake =2 cups per day and risk of CBT in younger children, although some estimates are imprecise. There was no association between maternal tea drinking and risk of CBT. © 2014 Springer International Publishing Switzerland.

DOI 10.1007/s10552-014-0437-8
Citations Scopus - 2Web of Science - 2
2014 Milne E, Greenop KR, Fritschi L, Attia J, Bailey HD, Scott RJ, et al., 'Childhood and parental diagnostic radiological procedures and risk of childhood brain tumors', Cancer Causes and Control, 25 375-383 (2014) [C1]

Purpose: Childhood brain tumors (CBT) are the second most common type of childhood cancer and the leading cause of childhood cancer mortality. Few causes of CBT are known, but par... [more]

Purpose: Childhood brain tumors (CBT) are the second most common type of childhood cancer and the leading cause of childhood cancer mortality. Few causes of CBT are known, but parental, fetal, and early life exposures are likely to be important given the early age at diagnosis of many cases. We aimed to investigate whether parents' diagnostic radiological procedures before conception, in the mother during pregnancy or the child's procedures were associated with an increased risk of CBT. Methods: This population-based case-control study was conducted between 2005 and 2010. Cases were identified through all ten Australian pediatric oncology centers, and controls via nationwide random-digit dialing; frequency-matched to cases on age, sex and state of residence. Information on radiological exposures in the time periods of interest was obtained for 306 case and 950 control families through mailed questionnaires. Analysis used unconditional logistic regression, adjusting for matching variables and potential confounders. Results: We found no evidence of positive associations between risk of CBT overall and childhood or parental pre-pregnancy radiological procedures. Increased ORs for high-grade gliomas associated with childhood radiological procedures were based on small numbers and may be due to chance. Conclusions: Given the evidence for an increased risk of CBT in cohort studies of computed tomography (CT) in childhood, the lack of such an association in our study may be due to the reduced intensity of CTs after 2001. Future research to investigate the safety of fetal exposure to more intense procedures like CT scans is needed. © 2014 Springer International Publishing Switzerland.

DOI 10.1007/s10552-014-0338-x
Citations Scopus - 1Web of Science - 1
Co-authors Rodney Scott
2014 Bailey HD, Miller M, Greenop KR, Bower C, Attia J, Marshall GM, et al., 'Paternal intake of folate and vitamins B6 and B12 before conception and risk of childhood acute lymphoblastic leukemia', Cancer Causes and Control, 25 1615-1625 (2014) [C1]

© 2014, Springer International Publishing Switzerland. Purpose: We investigated whether paternal dietary intake of folate before conception is associated with the risk of childho... [more]

© 2014, Springer International Publishing Switzerland. Purpose: We investigated whether paternal dietary intake of folate before conception is associated with the risk of childhood acute lymphoblastic leukemia (ALL) in a nationwide case¿control study. Methods: Data on dietary folate intake during the 6¿months before the child¿s conception were collected from 285 case fathers and 595 control fathers using a dietary questionnaire. Nutrient intake was quantified using a customized computer software package based on Australian food composition databases. Data on folate intake were analyzed using unconditional logistic regression, adjusting for study-matching variables, total energy, and potentially confounding variables. In a subset of 229 cases and 420 controls, data on vitamin B6 and vitamin B12 intake were also analyzed. Results: No consistent associations were seen with paternal dietary intake of folate or vitamin B6. Higher levels of paternal dietary vitamin B12 were appeared to be associated with an increased risk of childhood ALL, with those in the highest tertile of consumption having an OR of 1.51 (0.97, 2.36). The use of supplements containing folate and vitamins B6 or B12 was rare. Conclusions: We did not find any biologically plausible evidence that paternal nutrition in the period leading up to conception was associated with childhood ALL. Our finding for vitamin B12 may be a chance finding, given the number of analyses performed, or be attributable to participation bias because parents with a tertiary education had the lowest level of B12 intake and tertiary education was more common among control than case parents.

DOI 10.1007/s10552-014-0466-3
Citations Scopus - 4Web of Science - 2
2014 White JH, Attia J, Sturm J, Carter G, Magin P, 'Predictors of depression and anxiety in community dwelling stroke survivors: A cohort study', Disability and Rehabilitation, 36 1975-1982 (2014) [C1]

© 2014 Informa UK Ltd. Purpose: Few longitudinal studies explore post-stroke patterns of psychological morbidity and factors contributing to their change over time. We aimed to e... [more]

© 2014 Informa UK Ltd. Purpose: Few longitudinal studies explore post-stroke patterns of psychological morbidity and factors contributing to their change over time. We aimed to explore predictors of post-stroke depression (PSD) and post-stroke anxiety over a 12-month period. Methods: A prospective cohort study. Consecutively recruited stroke patients (n=134) participated in face-to-face interviews at baseline, 3, 6, 9, and 12 months. Primary outcome measures were depression and anxiety (measured via Hospital Anxiety and Depression Scale). Independent variables included disability (Modified Rankin Scale), Quality-of-life (Assessment Quality-of-life), social support (Multi-dimensional Scale Perceived Social Support) and community participation (Adelaide Activities Profile (AAP)). Secondary outcomes were predictors of resolution and development of PSD and anxiety. Results: Anxiety (47%) was more common than depression (22%) at baseline. Anxiety (but not depression) scores improved over time. Anxiety post-stroke was positively associated with baseline PSD (p < 0.0001), baseline anxiety (p < 0.0001) and less disability (p=0.042). PSD was associated with baseline anxiety (p < 0.0001), baseline depression (p=0.0057), low social support (p=0.0161) and low community participation (p < 0.0001). The only baseline factor predicting the resolution of PSD (if depressed at baseline) was increased social support (p=0.0421). Factors that predicted the onset of depression (if not depressed at baseline) were low community participation (p=0.0015) and higher disability (p=0.0057). Conclusion: While more common than depression immediately post-stroke, anxiety attenuates while the burden of depression persists over 12 months. Clinical programs should assess anxiety and depression, provide treatment pathways for those identified, and address modifiable risk factors, especially social support and social engagement.Implications for RehabilitationPsychological distress post stroke is persisting.Multi-disciplinary teams that establish goals with patients promoting social and community engagement could assist in managing psychological morbidity.A shift towards promoting longer-term monitoring and management of stroke survivors must be undertaken, and should consider the factors that support and hinder psychological morbidity.

DOI 10.3109/09638288.2014.884172
Citations Scopus - 15Web of Science - 13
Co-authors Parker Magin, Gregory Carter
2014 Moayyeri A, Hsu Y-H, Karasik D, Estrada K, Xiao S-M, Nielson C, et al., 'Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium', HUMAN MOLECULAR GENETICS, 23 3054-3068 (2014) [C1]
DOI 10.1093/hmg/ddt675
Citations Scopus - 34Web of Science - 33
Co-authors Mark Mcevoy, Roseanne Peel, Liz Holliday, Christopher Oldmeadow, Rodney Scott
2014 Wilasrusmee C, Marjareonrungrung M, Eamkong S, Attia J, Poprom N, Jirasisrithum S, Thakkinstian A, 'Maggot therapy for chronic ulcer: A retrospective cohort and a meta-analysis', ASIAN JOURNAL OF SURGERY, 37 138-147 (2014) [C1]
DOI 10.1016/j.asjsur.2013.09.005
Citations Web of Science - 10
2014 Springelkamp H, Höhn R, Mishra A, Hysi PG, Khor CC, Loomis SJ, et al., 'Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process', Nature Communications, 5 (2014) [C1]

© 2014 Macmillan Publishers Limited. All rights reserved. Glaucoma is characterized by irreversible optic nerve degeneration and is the most frequent cause of irreversible blindn... [more]

© 2014 Macmillan Publishers Limited. All rights reserved. Glaucoma is characterized by irreversible optic nerve degeneration and is the most frequent cause of irreversible blindness worldwide. Here, the International Glaucoma Genetics Consortium conducts a meta-analysis of genome-wide association studies of vertical cup-disc ratio (VCDR), an important disease-related optic nerve parameter. In 21,094 individuals of European ancestry and 6,784 individuals of Asian ancestry, we identify 10 new loci associated with variation in VCDR. In a separate risk-score analysis of five case-control studies, Caucasians in the highest quintile have a 2.5-fold increased risk of primary open-angle glaucoma as compared with those in the lowest quintile. This study has more than doubled the known loci associated with optic disc cupping and will allow greater understanding of mechanisms involved in this common blinding condition.

DOI 10.1038/ncomms5883
Citations Scopus - 31
Co-authors Rodney Scott, Liz Holliday
2014 Loth DW, Artigas MS, Gharib SA, Wain LV, Franceschini N, Koch B, et al., 'Genome-wide association analysis identifies six new loci associated with forced vital capacity', NATURE GENETICS, 46 669-677 (2014) [C1]
DOI 10.1038/ng.3011
Citations Scopus - 41Web of Science - 40
Co-authors Christopher Oldmeadow, Rodney Scott, Liz Holliday
2014 Wilasrusmee C, Anothaisintawee T, Poprom N, McEvoy M, Attia J, Thakkinstian A, 'Diagnostic Scores for Appendicitis: A Systematic Review of Scores¿ Performance', British Journal of Medicine and Medical Research, 4 711-730 (2014) [C1]
DOI 10.9734/BJMMR/2014/5255
Co-authors Mark Mcevoy
2014 Handley TE, Hiles SA, Inder KJ, Kay-Lambkin FJ, Kelly BJ, Lewin TJ, et al., 'Predictors of Suicidal Ideation in Older People: A Decision Tree Analysis', AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 22 1325-1335 (2014) [C1]
DOI 10.1016/j.jagp.2013.05.009
Citations Scopus - 10Web of Science - 7
Co-authors Brian Kelly, Frances Kaylambkin, Terry Lewin, Mark Mcevoy, Roseanne Peel, Kerry Inder, Sarah Hiles
2014 Holliday EG, Traylor M, Malik R, Bevan S, Maguire J, Koblar SA, et al., 'Polygenic Overlap Between Kidney Function and Large Artery Atherosclerotic Stroke', STROKE, 45 3508-+ (2014) [C1]
DOI 10.1161/STROKEAHA.114.006609
Citations Scopus - 3Web of Science - 4
Co-authors Mark Mcevoy, Liz Holliday, Rodney Scott, Christopher Levi, Christopher Oldmeadow
2014 Williams D, Conn J, Talley N, Attia J, 'Reviewing the evidence base for the peripheral sensory examination', International Journal of Clinical Practice, 68 756-760 (2014) [C1]

Background Many students find the peripheral sensory examination confusing. We set out to summarise the evidence base in order to provide guidance on the most useful manoeuvres. M... [more]

Background Many students find the peripheral sensory examination confusing. We set out to summarise the evidence base in order to provide guidance on the most useful manoeuvres. Methods We performed a literature review starting with 5 secondary sources, supplemented by a literature search on MEDLINE. Results A useful approach to neuropathy is to divide these into large fibre sensory neuropathy (LFSN) in which vibration and proprioception are affected, and small fibre sensory neuropathy (SFSN) in which pain and temperature are affected. Positive sensory symptoms such as burning, electric or sunburn pain point to a SFSN; negative symptoms such as loss of sensation, numbness or deep pain point to a LFSN. If LFSN is suspected, the most reproducible and best studied physical examination is a 10g monofilament, but vibration sense is also useful. There is much less data on the best physical examination for a SFSN. The most appropriate diagnostic test for SFSN is quantitative sensory testing, whereas for LFSN a nerve conduction study is indicated. Conclusions A modest amount of evidence is available to guide peripheral sensory examination but more research is needed. © 2014 John Wiley & Sons Ltd.

DOI 10.1111/ijcp.12389
Co-authors Nicholas Talley
2014 Oldmeadow C, Holliday EG, McEvoy M, Scott R, Kwok JBJ, Mather K, et al., 'Concordance between direct and imputed APOE genotypes using 1000 genomes data', Journal of Alzheimer's Disease, 42 391-393 (2014) [C1]

© 2014 - IOS Press and the authors. All rights reserved. There are a growing number of large cohorts of older persons with genome-wide genotyping data available, but APOE is not ... [more]

© 2014 - IOS Press and the authors. All rights reserved. There are a growing number of large cohorts of older persons with genome-wide genotyping data available, but APOE is not included in any of the common microarray platforms. We compared directly measured APOE genotypes with those imputed using microarray data and the '1000 Genomes' dataset in a sample of 320 Caucasians. We find 90% agreement for e2/e3/e4 genotypes and 93% agreement for predicting e4 status, yielding kappa values of 0.81 and 0.84, respectively. More stringent thresholds around allele number estimates can increase this agreement to 90-97% and kappas of 0.90-0.93.

DOI 10.3233/JAD-140846
Citations Scopus - 2Web of Science - 2
Co-authors Liz Holliday, Rodney Scott, Christopher Oldmeadow, Peter Schofield, Mark Mcevoy
2014 Gunathilake R, Krishnamurthy V, Oldmeadow C, Kerr E, Padmakumar C, Attia J, et al., 'Relationships between age, other predictive variables, and the 90-day functional outcome after intravenous thrombolysis for acute ischemic stroke', AUSTRALASIAN JOURNAL ON AGEING, 33 19-19 (2014) [E3]
Co-authors Christopher Levi, Christopher Oldmeadow, Mark Parsons
2014 Tarrant SM, Hardy BM, Byth PL, Brown TL, Attia J, Balogh ZJ, 'Preventable mortality in geriatric hip fracture inpatients', Bone and Joint Journal, 69B 1178-1184 (2014) [C1]

© 2014 The British Editorial Society of Bone &amp; Joint Surgery. There is a high rate of mortality in elderly patients who sustain a fracture of the hip. We aimed to determine... [more]

© 2014 The British Editorial Society of Bone & Joint Surgery. There is a high rate of mortality in elderly patients who sustain a fracture of the hip. We aimed to determine the rate of preventable mortality and errors during the management of these patients. A 12 month prospective study was performed on patients aged > 65 years who had sustained a fracture of the hip. This was conducted at a Level 1 Trauma Centre with no orthogeriatric service. A multidisciplinary review of the medical records by four specialists was performed to analyse errors of management and elements of preventable mortality. During 2011, there were 437 patients aged > 65 years admitted with a fracture of the hip (85 years (66 to 99)) and 20 died while in hospital (86.3 years (67 to 96)). A total of 152 errors were identified in the 80 individual reviews of the 20 deaths. A total of 99 errors (65%) were thought to have at least a moderate effect on death; 45 reviews considering death (57%) were thought to have potentially been preventable. Agreement between the panel of reviewers on the preventability of death was fair. A larger-scale assessment of preventable mortality in elderly patients who sustain a fracture of the hip is required. Multidisciplinary review panels could be considered as part of the quality assurance process in the management of these patients.

DOI 10.1302/0301-620X.96B9.32814$2.00
Citations Scopus - 12Web of Science - 12
Co-authors Zsolt Balogh
2014 Lai JS, Attia JR, McEvoy M, Hure AJ, 'Biochemical Validation of the Older Australian¿s Food Frequency Questionnaire Using Carotenoids and Vitamin E', Nutrients, 6 4906-4917 (2014) [C1]
DOI 10.3390/nu6114906
Citations Scopus - 2Web of Science - 2
Co-authors Mark Mcevoy, Alexis Hure
2014 Islam MR, Attia J, Alauddin M, McEvoy M, McElduff P, Slater C, et al., 'Availability of arsenic in human milk in women and its correlation with arsenic in urine of breastfed children living in arsenic contaminated areas in Bangladesh.', Environmental Health: A Global Access Science Source, 13 1-10 (2014) [C1]
Citations Scopus - 4Web of Science - 3
Co-authors Roseanne Peel, Catherine Deste, Patrick Mcelduff, Mark Mcevoy, Wayne Smith, Milton Hasnat
2014 Johnson NA, Kypri K, Latter J, McElduff P, Saunders JB, Saitz R, et al., 'Prevalence of unhealthy alcohol use in hospital outpatients', Drug and Alcohol Dependence, 144 270-273 (2014) [C1]

© 2014 Elsevier Ireland Ltd. Background: Few studies have examined the prevalence of unhealthy alcohol use in the hospital outpatient setting. Our aim was to estimate the prevale... [more]

© 2014 Elsevier Ireland Ltd. Background: Few studies have examined the prevalence of unhealthy alcohol use in the hospital outpatient setting. Our aim was to estimate the prevalence of unhealthy alcohol use among patients attending a broad range of outpatient clinics at a large public hospital in Australia. Methods: Adult hospital outpatients were invited to complete the Alcohol Use Disorders Identification Test Consumption questions (AUDIT-C) using an iPad as part of a randomised trial testing the efficacy of alcohol electronic screening and brief intervention. Unhealthy alcohol use was defined as an AUDIT-C score =5 among men and =4 among women. Results: Sixty percent (3616/6070) of invited hospital outpatients consented, of whom 89% (3206/3616) provided information on their alcohol consumption (either reported they had not consumed any alcohol in the last 12 months or completed the AUDIT-C). The prevalence of unhealthy alcohol use was 34.7% (95% confidence interval [CI]: 33.0-36.3%). The prevalence among men aged 18-24 years, 25-39 years, 40-59 years and 60 years and older, was 74.4% (95% CI: 68.4-80.4%), 54.3% (95% CI: 48.7-59.8%), 44.1% (95% CI: 39.9-48.3%), and 27.0% (95% CI: 23.6-30.4%), respectively (43.1% overall; 95% CI: 40.8-45.5%). The prevalence among women aged 18-24 years, 25-39 years, 40-59 years, and 60 years and older, was 48.6% (95% CI: 39.2-58.1%), 36.9% (95% CI: 31.2-42.6%), 25.2% (95% CI: 21.5-29.0%) and 14.5% (95% CI: 11.7-17.3%), respectively (24.9% overall; 95% CI: 22.7-27.1%). Conclusion: A large number of hospital outpatients who are not currently seeking treatment for their drinking could benefit from effective intervention in this setting.

DOI 10.1016/j.drugalcdep.2014.08.014
Citations Scopus - 5Web of Science - 4
Co-authors Kypros Kypri, Joanna Latter, Patrick Mcelduff, Natalie Johnson, A Dunlop, Luke Wolfenden
2014 de Zeeuw EL, van Beijsterveldt CEM, Glasner TJ, Bartels M, Ehli EA, Davies GE, et al., 'Polygenic scores associated with educational attainment in adults predict educational achievement and ADHD symptoms in children', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 165 510-520 (2014)

The American Psychiatric Association estimates that 3 to 7 per cent of all school aged children are diagnosed with attention deficit hyperactivity disorder (ADHD). Even after corr... [more]

The American Psychiatric Association estimates that 3 to 7 per cent of all school aged children are diagnosed with attention deficit hyperactivity disorder (ADHD). Even after correcting for general cognitive ability, numerous studies report a negative association between ADHD and educational achievement. With polygenic scores we examined whether genetic variants that have a positive influence on educational attainment have a protective effect against ADHD. The effect sizes from a large GWA meta-analysis of educational attainment in adults were used to calculate polygenic scores in an independent sample of 12-year-old children from the Netherlands Twin Register. Linear mixed models showed that the polygenic scores significantly predicted educational achievement, school performance, ADHD symptoms and attention problems in children. These results confirm the genetic overlap between ADHD and educational achievement, indicating that one way to gain insight into genetic variants responsible for variation in ADHD is to include data on educational achievement, which are available at a larger scale. © 2014 Wiley Periodicals, Inc.

DOI 10.1002/ajmg.b.32254
Citations Scopus - 10
Co-authors Christopher Oldmeadow, Liz Holliday, Rodney Scott
2014 Ewald B, Attia J, McElduff P, 'How many steps are enough? dose-response curves for pedometer steps and multiple health markers in a community-based sample of older Australians', Journal of Physical Activity and Health, 11 509-518 (2014) [C1]

Background: Although an overall public health target of 10,000 steps per day has been advocated, the dose-response relationship for each health benefit of physical activity may di... [more]

Background: Although an overall public health target of 10,000 steps per day has been advocated, the dose-response relationship for each health benefit of physical activity may differ. Methods: A representative community sample of 2458 Australian residents aged 55-85 wore a pedometer for a week in 2005-2007 and completed a health assessment. Age-standardized steps per day were compared with multiple markers of health using locally weighted regression to produce smoothed dose-response curves and then to select the steps per day matching 60% or 80% of the range in each health marker. Results: There is a linear relationship between activity level and markers of inflammation throughout the range of steps per day; this is also true for BMI in women and high density lipoprotein in men. For other markers, including waist:hip ratio, fasting glucose, depression, and SF-36 scores, the benefit of physical activity is mostly in the lower half of the distribution. Conclusions: Older adults have no plateau in the curve for some health outcomes, even beyond 12,000 steps per day. For other markers, however, there is a threshold effect, indicating that most of the benefit is achieved by 8000 steps per day, supporting this as a suitable public health target for older adults. © 2014 Human Kinetics, Inc.

DOI 10.1123/jpah.2012-0091
Citations Scopus - 7Web of Science - 5
Co-authors Patrick Mcelduff, Ben Ewald
2014 McEvoy M, Schofield P, Smith W, Agho K, Mangoni AA, Soiza RL, et al., 'Memory Impairment is Associated with Serum Methylarginines in Older Adults', CURRENT ALZHEIMER RESEARCH, 11 97-106 (2014) [C1]
Citations Scopus - 6Web of Science - 6
Co-authors Peter Schofield, Wayne Smith, Mark Mcevoy, Roseanne Peel
2014 Greenop KR, Peters S, Bailey HD, Fritschi L, Attia J, Scott RJ, et al., 'Erratum to: Exposure to pesticides and the risk of childhood brain tumors', Cancer Causes and Control, 25 1239-1240 (2014)
DOI 10.1007/s10552-014-0418-y
Co-authors Rodney Scott
2014 Abdullah N, Attia J, Oldmeadow C, Scott RJ, Holliday EG, 'The Architecture of Risk for Type 2 Diabetes: Understanding Asia in the Context of Global Findings', INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, (2014) [C1]
DOI 10.1155/2014/593982
Citations Scopus - 18Web of Science - 1
Co-authors Christopher Oldmeadow, Liz Holliday, Rodney Scott
2014 Denham JW, Joseph D, Lamb DS, Spry NA, Duchesne G, Matthews J, et al., 'Short-term androgen suppression and radiotherapy versus intermediate-term androgen suppression and radiotherapy, with or without zoledronic acid, in men with locally advanced prostate cancer (TROG 03.04 RADAR): an open-label, randomised, phase 3 factorial trial', LANCET ONCOLOGY, 15 1076-1089 (2014) [C1]
DOI 10.1016/S1470-2045(14)70328-6
Citations Scopus - 45Web of Science - 44
Co-authors Jim Denham, Allison Steigler, Christopher Oldmeadow
2014 Handley TE, Kay-Lambkin FJ, Inder KJ, Lewin TJ, Attia JR, Fuller J, et al., 'Self-reported contacts for mental health problems by rural residents: Predicted service needs, facilitators and barriers', BMC Psychiatry, 14 (2014) [C1]

© 2014 Handley et al.; licensee BioMed Central Ltd. Background: Rural and remote Australians face a range of barriers to mental health care, potentially limiting the extent to wh... [more]

© 2014 Handley et al.; licensee BioMed Central Ltd. Background: Rural and remote Australians face a range of barriers to mental health care, potentially limiting the extent to which current services and support networks may provide assistance. This paper examines self-reported mental health problems and contacts during the last 12¿months, and explores cross-sectional associations between potential facilitators/barriers and professional and non-professional help-seeking, while taking into account expected associations with socio-demographic and health-related factors. Methods: During the 3-year follow-up of the Australian Rural Mental Health Study (ARMHS) a self-report survey was completed by adult rural residents (N = 1,231; 61% female 77% married; 22% remote location; mean age = 59¿years), which examined socio-demographic characteristics, current health status factors, predicted service needs, self-reported professional and non-professional contacts for mental health problems in the last 12¿months, other aspects of help-seeking, and perceived barriers. Results: Professional contacts for mental health problems were reported by 18% of the sample (including 14% reporting General Practitioner contacts), while non-professional contacts were reported by 16% (including 14% reporting discussions with family/friends). Perceived barriers to health care fell under the domains of structural (e.g., costs, distance), attitudinal (e.g., stigma concerns, confidentiality), and time commitments. Participants with 12-month mental health problems who reported their needs as met had the highest levels of service use. Hierarchical logistic regressions revealed a dose-response relationship between the level of predicted need and the likelihood of reporting professional and non-professional contacts, together with associations with socio-demographic characteristics (e.g., gender, relationships, and financial circumstances), suicidal ideation, and attitudinal factors, but not geographical remoteness. Conclusions: Rates of self-reported mental health problems were consistent with baseline findings, including higher rural contact rates with General Practitioners. Structural barriers displayed mixed associations with help-seeking, while attitudinal barriers were consistently associated with lower service contacts. Developing appropriate interventions that address perceptions of mental illness and attitudes towards help-seeking is likely to be vital in optimising treatment access and mental health outcomes in rural areas.

DOI 10.1186/s12888-014-0249-0
Citations Scopus - 8Web of Science - 5
Co-authors Brian Kelly, Natasha Weaver, Frances Kaylambkin, Kerry Inder, Terry Lewin
2014 Gunathilake R, Krishnamurthy V, Oldmeadow C, Kerr E, Padmakumar C, Attia J, et al., 'Relationships between age, other predictive variables, and the 90-day functional outcome after intravenous thrombolysis for acute ischemic stroke', International Journal of Stroke, 9 E36-E37 (2014) [O1]
DOI 10.1111/ijs.12347
Co-authors Mark Parsons, Christopher Oldmeadow, Christopher Levi
2014 Squance ML, Reeves GEM, Attia J, 'Patient Reported Frequency of Lupus Flare: Associations with Foundation Makeup and Sunscreen Use', Journal of Cosmetics, Dermatological Sciences and Applications, 4 344-354 (2014) [C1]
DOI 10.4236/jcdsa.2014.45046
2014 Golledge J, Clancy P, Maguire J, Lincz L, Koblar S, Mcevoy M, et al., 'Plasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidence', Stroke, 45 1064-1068 (2014) [C1]

BACKGROUND AND PURPOSE - : Studies in rodent models suggest that upregulating angiopoietin-1 (Angpt1) improves stroke outcomes. The aims of this study were to assess the associati... [more]

BACKGROUND AND PURPOSE - : Studies in rodent models suggest that upregulating angiopoietin-1 (Angpt1) improves stroke outcomes. The aims of this study were to assess the association of plasma Angpt1 with stroke occurrence and outcome. METHODS - : Plasma Angpt1 was measured in 336 patients who had experienced a recent stroke and 321 healthy controls with no stroke history. Patients with stroke (n=285) were reassessed at 3 months and plasma Angpt1 concentration on admission compared between those with severe and minor disability as assessed by the modified Rankin scale. In a separate cohort of 4032 community-acquired older men prospectively followed for a minimum of 6 years, the association of plasma Angpt1 with stroke incidence was examined. RESULTS - : Median plasma Angpt1 was 3-fold lower in patients who had experienced a recent stroke (6.42, interquartile range, 4.26-9.53 compared with 17.36; interquartile range, 14.01-22.46 ng/mL; P < 0.001) and remained associated with stroke after adjustment for other risk factors. Plasma Angpt1 concentrations on admission were lower in patients who had severe disability or died at 3 months (median, 5.52; interquartile range, 3.81-8.75 ng/mL for modified Rankin scale 3-6; n=91) compared with those with minor disability (median, 7.04; interquartile range, 4.75-9.92 ng/mL for modified Rankin scale 0-2; n=194), P=0.012, and remained negatively associated with severe disability or death after adjusting for other risk factors. Plasma Angpt1 was not predictive of stroke incidence in community-dwelling older men. CONCLUSIONS - : Plasma Angpt1 concentrations are low after ischemic stroke particularly in patients with poor stroke outcomes at 3 months. Interventions effective at upregulating Angpt1 could potentially improve stroke outcomes. © 2014 American Heart Association, Inc.

DOI 10.1161/STROKEAHA.113.004339
Citations Scopus - 6Web of Science - 4
Co-authors Christopher Levi, Mark Mcevoy, Lisa Lincz
2014 The Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Effects), 'Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: A pooled analysis of 97 prospective cohorts with 1·8 million participants', The Lancet, 383 970-983 (2014) [C1]
DOI 10.1016/S0140-6736(13)61836-X
Citations Scopus - 195
Co-authors Catherine Deste
2014 Gupta SK, Lewis G, Rogers KM, Attia J, Rostron K, O'Neill L, et al., 'Quantitative (99m)Tc DTPA renal transplant scintigraphic parameters: assessment of interobserver agreement and correlation with graft pathologies.', American Journal of Nuclear Medicine and Molecular Imaging, 4 213-224 (2014) [C1]
2014 Dewar DC, White A, Attia J, Tarrant SM, King KL, Balogh ZJ, 'Comparison of postinjury multiple-organ failure scoring systems: Denver versus sequential organ failure assessment', Journal of Trauma and Acute Care Surgery, 77 624-629 (2014) [C1]

Copyright © 2014 by Lippincott Williams &amp; Wilkins. BACKGROUND: The Denver and Sequential Organ Failure Assessment (SOFA) scores have been used widely to describe the epidem... [more]

Copyright © 2014 by Lippincott Williams & Wilkins. BACKGROUND: The Denver and Sequential Organ Failure Assessment (SOFA) scores have been used widely to describe the epidemiology of postinjury multiple-organ failure; however, differences in these scores make it difficult to compare incidence, duration, and mortality of multiple-organ failure. The study aim was to compare the performance of the Denver and SOFA scores with respect to the outcomes of mortality, intensive care unit length of stay (ICU LOS), and ventilator days. METHODS: A 60-month prospective epidemiologic study was undertaken at an Australian Level I trauma center. Data were collected on trauma patients that met inclusion criteria (ICU admission, Injury Severity Score [ISS] 9 15, age 9 18 years, head Abbreviated Injury Scale [AIS] score G 3, survival for 948 hours). Demographics, ISS, physiologic parameters, SOFA and Denver scores, and outcome data were prospectively collected. Sensitivity/specificity and receiver operating characteristic curve were calculated for both scores. Analysis was also completed for a Day 3 postinjury SOFA and Denver score. RESULTS: A total of 140 patients met the inclusion criteria (mean [SD] age, 47 [21] years; ISS, 30; male, 69%; mortality rate, 6%; mean [SD] ICU LOS, 9 [7] days; mean [SD] ventilation period, 6 [7] days). There was no difference in the score performance predicting mortality. Day 3 SOFA score of 4 or greater outperformed the Denver score of greater than 3 when predicting ICU LOS and ventilator days (area under the curve, 0.83 vs. 0.69, 0.86 vs. 0.73, respectively). The SOFA score was more sensitive and the Denver score was more specific when predicting mortality, ICU LOS, and ventilator days. CONCLUSION: Both scores had similar performance predicting mortality; however, the Day 3 SOFA score outperforms the Denver score when predicting ICU LOS and ventilator days. Either score could be superior based on whether one is seeking to optimize specificity or sensitivity. It is important to note that these findings are in a non-head-injured population and that there are practical difficulties using the SOFA in head-injured patients. LEVEL OF EVIDENCE: Diagnostic study, level II.

DOI 10.1097/TA.0000000000000406
Citations Scopus - 11Web of Science - 11
Co-authors Zsolt Balogh
2014 Wang G, Murphy VE, Namazy J, Powell H, Schatz M, Chambers C, et al., 'The risk of maternal and placental complications in pregnant women with asthma: A systematic review and meta-analysis', Journal of Maternal-Fetal and Neonatal Medicine, 27 934-942 (2014) [C1]

Objective: To investigate if maternal asthma is associated with an increased risk of maternal and placental complications in pregnancy. Methods: Electronic databases were searched... [more]

Objective: To investigate if maternal asthma is associated with an increased risk of maternal and placental complications in pregnancy. Methods: Electronic databases were searched for the following terms: (asthma or wheeze) and (pregnan* or perinat* or obstet*). Cohort studies published between January 1975 and March 2012 were considered for inclusion. Forty publications met the inclusion criteria, reporting at least one maternal or placental complication in pregnant women with and without asthma. Relative risk (RR) with 95% confidence intervals (CIs) was calculated. Results: Maternal asthma was associated with a significantly increased risk of cesarean section (RR=1.31, 95%CI=[1.22-1.39]), gestational diabetes (RR=1.39, 95%CI=[1.17-1.66] ), hemorrhage (antepartum: RR=1.25, 95%CI=[1.10-1.42]; postpartum: RR=1.29, 95%CI=[1.18-1.41] ), placenta previa (RR=1.23, 95%CI=[1.07-1.40]), placental abruption (RR=1.29, 95%CI=[1.14-1.47] ) and premature rupture of membranes (RR=1.21, 95%CI=1.07-1.37). Moderate to severe asthma significantly increased the risk of cesarean section (RR=1.19, 95%CI=[1.09-1.31]) and gestational diabetes (RR=1.19, 95%CI=[1.06-1.33] ) compared to mild asthma. Bronchodilator use was associated with a significantly lowered risk of gestational diabetes (RR=0.64, 95%CI=[0.57-0.72]). Conclusions: Pregnant women with asthma are at increased risk of maternal and placental complications, and women with moderate/severe asthma may be at particular risk. Further studies are required to elucidate whether adequate control of asthma during pregnancy reduces these risks. © 2014 Informa UK Ltd. All rights reserved.

DOI 10.3109/14767058.2013.847080
Citations Scopus - 18Web of Science - 18
Co-authors Vanessa Murphy, Peter Gibson
2014 Napthali K, Boyle M, Tran H, Schofield PW, Peel R, McEvoy M, et al., 'Thyroid antibodies, autoimmunity and cognitive decline: is there a population-based link?', Dement Geriatr Cogn Dis Extra, 4 140-146 (2014) [C1]
DOI 10.1159/000362716
Co-authors Roseanne Peel, Christopher Oldmeadow, Peter Schofield, Mark Mcevoy
2014 Jackel D, Attia J, Pickles R, 'General medicine advanced training: lessons from the John Hunter training programme.', Intern Med J, 44 302-306 (2014) [C2]
DOI 10.1111/imj.12357
2013 Johnson NA, Kypri K, Saunders JB, Saitz R, Attia J, Dunlop A, et al., 'The hospital outpatient alcohol project (HOAP): protocol for an individually randomized, parallel-group superiority trial of electronic alcohol screening and brief intervention versus screening alone for unhealthy alcohol use.', Addict Sci Clin Pract, 8 14 (2013) [C3]
DOI 10.1186/1940-0640-8-14
Citations Scopus - 4
Co-authors Patrick Mcelduff, Natalie Johnson, Luke Wolfenden, A Dunlop, Kypros Kypri
2013 Handley TE, Attia JR, Inder KJ, Kay-Lambkin FJ, Barker D, Lewin TJ, Kelly BJ, 'Longitudinal course and predictors of suicidal ideation in a rural community sample.', Australian & New Zealand Journal of Psychiatry, 47 1032-1040 (2013) [C1]
DOI 10.1177/0004867413495318
Citations Scopus - 7Web of Science - 6
Co-authors Frances Kaylambkin, Kerry Inder, Terry Lewin, Brian Kelly
2013 Vashum KP, McEvoy M, Shi Z, Milton AH, Islam MR, Sibbritt D, et al., 'Is dietary zinc protective for type 2 diabetes? Results from the Australian longitudinal study on women's health', BMC Endocrine Disorders, 13 (2013) [C1]
DOI 10.1186/1472-6823-13-40
Citations Scopus - 11Web of Science - 10
Co-authors Amanda Patterson, Milton Hasnat, Deborah Loxton, Mark Mcevoy, Julie Byles
2013 Walsh B, Slater S, Nair B, Attia J, 'The relationship between the apolipoprotein E e4 allele and hippocampal MRI volume in community dwelling individuals with mild Alzheimer's disease', Degenerative Neurological and Neuromuscular Disease, 3 11-14 (2013) [C1]
DOI 10.2147/DNND.S40835
2013 Johnson NA, Kypri K, Attia J, 'Development of an electronic alcohol screening and brief intervention program for hospital outpatients with unhealthy alcohol use.', JMIR Res Protoc, 2 e36 (2013) [C1]
DOI 10.2196/resprot.2697
Citations Scopus - 5
Co-authors Natalie Johnson, Kypros Kypri
2013 Gunathilake R, Oldmeadow C, McEvoy M, Kelly B, Inder K, Schofield P, Attia J, 'Mild Hyponatremia Is Associated With Impaired Cognition And Falls In Community-Dwelling Older Persons', Journal of the American Geriatrics Society, 61 1838-1839 (2013) [C1]
DOI 10.1111/jgs.12468
Citations Scopus - 20Web of Science - 18
Co-authors Christopher Oldmeadow, Brian Kelly, Peter Schofield, Mark Mcevoy, Kerry Inder
2013 Thakkinstian A, McKay GJ, Silvestri J, Chakravarthy U, Attia J, 'FIVE AUTHORS REPLY', AMERICAN JOURNAL OF EPIDEMIOLOGY, 177 1024-1025 (2013) [C3]
DOI 10.1093/aje/kwt068
2013 Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, et al., 'Genome-wide association analyses identify 18 new loci associated with serum urate concentrations', Nature Genetics, 45 145-154 (2013)

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Glo... [more]

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout. © 2013 Nature America, Inc. All rights reserved.

DOI 10.1038/ng.2500
Co-authors Rodney Scott, Liz Holliday, Christopher Oldmeadow
2013 Attia JR, Pearce R, 'The use, misuse and abuse of dabigatran', MEDICAL JOURNAL OF AUSTRALIA, 198 356-357 (2013) [C3]
DOI 10.5694/mja12.10729
Citations Scopus - 7Web of Science - 7
2013 Yadav S, Cotlarciuc I, Munroe PB, Khan MS, Nalls MA, Bevan S, et al., 'Genome-Wide Analysis of Blood Pressure Variability and Ischemic Stroke', Stroke, 44 2703-2709 (2013) [C1]
DOI 10.1161/STROKEAHA.113.002186
Citations Scopus - 9Web of Science - 7
Co-authors Mark Mcevoy, Rodney Scott, Liz Holliday
2013 Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, et al., 'Genome-wide association analyses identify 18 new loci associated with serum urate concentrations', Nature Genetics, 45 145-154 (2013) [C1]

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from &gt;140,000 individuals of European ancestry within the ... [more]

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout. © 2013 Nature America, Inc. All rights reserved.

DOI 10.1038/ng.2500
Citations Scopus - 204Web of Science - 196
Co-authors Liz Holliday, Rodney Scott, Christopher Oldmeadow
2013 Buitendijk GHS, Rochtchina E, Myers C, Van Duijn CM, Lee KE, Klein BEK, et al., 'Prediction of age-related macular degeneration in the general population: The three continent AMD consortium', Ophthalmology, 120 2644-2655 (2013) [C1]
DOI 10.1016/j.ophtha.2013.07.053
Citations Scopus - 34Web of Science - 40
Co-authors Liz Holliday
2013 Schache M, Richardson AJ, Mitchell P, Wang JJ, Rochtchina E, Viswanathan AC, et al., 'Genetic association of refractive error and axial length with 15q14 but not 15q25 in the Blue Mountains Eye Study Cohort', Ophthalmology, 120 292-297 (2013) [C1]
Citations Scopus - 13Web of Science - 10
Co-authors Rodney Scott, Liz Holliday
2013 Handley TE, Kay-Lambkin FJ, Baker AL, Lewin TJ, Kelly BJ, Inder KJ, et al., 'Incidental treatment effects of CBT on suicidal ideation and hopelessness', JOURNAL OF AFFECTIVE DISORDERS, 151 275-283 (2013) [C1]
DOI 10.1016/j.jad.2013.06.005
Citations Scopus - 8Web of Science - 7
Co-authors Amanda Baker, Frances Kaylambkin, Kerry Inder, Terry Lewin, Brian Kelly
2013 McEvoy MA, Schofield P, Smith W, Agho K, Mangoni AA, Soiza RL, et al., 'Serum methylarginines and incident depression in a cohort of older adults', Journal of Affective Disorders, 151 493-499 (2013) [C1]
DOI 10.1016/j.jad.2013.06.033
Citations Scopus - 7Web of Science - 6
Co-authors Wayne Smith, Brian Kelly, Peter Schofield, Mark Mcevoy, Kerry Inder, Roseanne Peel
2013 Hunt JJ, Lumsdaine W, Attia J, Balogh ZJ, 'AO type-C distal radius fractures: the influence of computed tomography on surgeon's decision-making', ANZ JOURNAL OF SURGERY, 83 676-678 (2013) [C3]
DOI 10.1111/j.1445-2197.2012.06311.x
Citations Scopus - 4Web of Science - 4
Co-authors Zsolt Balogh
2013 Williams FMK, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, et al., 'Ischemic stroke is associated with the ABO locus: The EuroCLOT Study', Annals of Neurology, 73 16-31 (2013) [C1]
Citations Scopus - 49Web of Science - 45
Co-authors Rodney Scott, Christopher Levi, Liz Holliday
2013 Minelli C, De Grandi A, Weichenberger CX, Goegele M, Modenese M, Attia J, et al., 'Importance of Different Types of Prior Knowledge in Selecting Genome-Wide Findings for Follow-Up', GENETIC EPIDEMIOLOGY, 37 205-213 (2013) [C1]
DOI 10.1002/gepi.21705
Citations Scopus - 7Web of Science - 5
2013 Thompson JR, Goegele M, Weichenberger CX, Modenese M, Attia J, Barrett JH, et al., 'SNP Prioritization Using a Bayesian Probability of Association', GENETIC EPIDEMIOLOGY, 37 214-221 (2013) [C1]
DOI 10.1002/gepi.21704
Citations Scopus - 5Web of Science - 3
2013 Kongtharvonskul J, Attia J, Thamakaison S, Kijkunasathian C, Woratanarat P, Thakkinstian A, 'Clinical outcomes of double- vs single-bundle anterior cruciate ligament reconstruction: A systematic review of randomized control trials', SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, 23 1-14 (2013) [C1]
DOI 10.1111/j.1600-0838.2011.01439.x
Citations Scopus - 12Web of Science - 11
2013 Greenop KR, Peters S, Bailey HD, Fritschi L, Attia J, Scott RJ, et al., 'Exposure to pesticides and the risk of childhood brain tumors', CANCER CAUSES & CONTROL, 24 1269-1278 (2013) [C1]
DOI 10.1007/s10552-013-0205-1
Citations Scopus - 18Web of Science - 17
Co-authors Rodney Scott
2013 Rattanasiri S, McDaniel DO, McEvoy M, Anothaisintawee T, Sobhonslidsuk A, Attia J, Thakkinstian A, 'The association between cytokine gene polymorphisms and graft rejection in liver transplantation: A systematic review and meta-analysis', TRANSPLANT IMMUNOLOGY, 28 62-70 (2013) [C1]
DOI 10.1016/j.trim.2012.10.003
Citations Scopus - 3Web of Science - 3
Co-authors Mark Mcevoy
2013 Rietveld CA, Medland SE, Derringer J, Yang J, Esko T, Martin NW, et al., 'GWAS of 126,559 individuals identifies genetic variants associated with educational attainment', Science, 340 1467-1471 (2013) [C1]
Citations Scopus - 221Web of Science - 215
Co-authors Liz Holliday, Rodney Scott, Christopher Oldmeadow
2013 Magee CA, Holliday EG, Attia JR, Kritharides L, Banks E, 'Investigation of the relationship between sleep duration, all-cause mortality, and preexisting disease', Sleep Medicine, 14 591-596 (2013) [C1]
Citations Scopus - 20Web of Science - 18
Co-authors Liz Holliday
2013 Stambolian D, Wojciechowski R, Oexle K, Pirastu M, Li X, Raffel LJ, et al., 'Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error', Human Molecular Genetics, 22 2754-2764 (2013) [C1]
Citations Scopus - 22Web of Science - 22
Co-authors Liz Holliday, Rodney Scott
2013 Ranasinghe WKB, Attia J, Oldmeadow C, Lawrentschuk N, Robertson J, Ranasinghe T, et al., 'Bladder carcinoma in situ (CIS) in Australia: a rising incidence for an under-reported malignancy', BJU International, 112 46-52 (2013) [C1]
DOI 10.1111/bju.12052
Citations Scopus - 2Web of Science - 3
Co-authors Christopher Oldmeadow
2013 Holliday S, Magin P, Oldmeadow C, Attia J, Dunbabin J, Henry J, et al., 'An examination of the influences on New South Wales general practitioners regarding the provision of opioid substitution therapy', Drug and Alcohol Review, 32 495-503 (2013) [C1]
DOI 10.1111/dar.12046
Citations Scopus - 7Web of Science - 5
Co-authors Parker Magin, A Dunlop, Christopher Oldmeadow
2013 Allen J, Inder KJ, Lewin TJ, Attia JR, Kay-Lambkin FJ, Baker AL, et al., 'Integrating and extending cohort studies: lessons from the eXtending Treatments, Education and Networks in Depression (xTEND) study', BMC Medical Research Methodology, 13 (2013) [C1]
DOI 10.1186/1471-2288-13-122
Citations Scopus - 5Web of Science - 4
Co-authors Terry Lewin, Kerry Inder, Frances Kaylambkin, Brian Kelly, Amanda Baker
2013 Gupta K, Dhawan A, Abel C, Talley N, Attia J, 'A re-evaluation of the scratch test for locating the liver edge', BMC GASTROENTEROLOGY, 13 (2013) [C1]
DOI 10.1186/1471-230X-13-35
Citations Scopus - 3Web of Science - 5
Co-authors Nicholas Talley
2013 Vejakama P, Thakkinstian A, Ingsathit A, Dhanakijcharoen P, Attia J, 'Prognostic factors of all-cause mortalities in continuous ambulatory peritoneal dialysis: a cohort study', BMC NEPHROLOGY, 14 (2013) [C1]
DOI 10.1186/1471-2369-14-28
Citations Scopus - 3Web of Science - 2
2013 Courtney RJ, Paul CL, Sanson-Fisher RW, Macrae FA, Carey ML, Attia J, McEvoy M, 'Individual- and provider-level factors associated with colorectal cancer screening in accordance with guideline recommendation: a community-level perspective across varying levels of risk', BMC PUBLIC HEALTH, 13 (2013) [C1]
DOI 10.1186/1471-2458-13-248
Citations Scopus - 8Web of Science - 5
Co-authors Chris Paul, Mariko Carey, Mark Mcevoy, Rob Sanson-Fisher
2013 Robertson J, McElduff P, Pearson S-A, Henry DA, Inder KJ, Attia JR, 'The health services burden of heart failure: an analysis using linked population health data-sets (vol 12, pg 103, 2012)', BMC HEALTH SERVICES RESEARCH, 13 (2013) [O1]
DOI 10.1186/1472-6963-13-179
Citations Scopus - 1Web of Science - 1
Co-authors Patrick Mcelduff, Kerry Inder, Mddah01
2013 Allen J, Inder KJ, Lewin TJ, Attia JR, Kelly BJ, 'Construct validity of the Assessment of Quality of Life - 6D (AQoL-6D) in community samples', HEALTH AND QUALITY OF LIFE OUTCOMES, 11 (2013) [C1]
DOI 10.1186/1477-7525-11-61
Citations Scopus - 12Web of Science - 11
Co-authors Terry Lewin, Brian Kelly, Kerry Inder
2013 Allen J, Inder KJ, Harris ML, Lewin TJ, Attia JR, Kelly BJ, 'Quality of life impact of cardiovascular and affective conditions among older residents from urban and rural communities', HEALTH AND QUALITY OF LIFE OUTCOMES, 11 (2013) [C1]
DOI 10.1186/1477-7525-11-140
Citations Scopus - 5Web of Science - 5
Co-authors Terry Lewin, Brian Kelly, Kerry Inder, Melissa Harris
2013 Mangoni AA, Zinellu A, Carru C, Attia JR, McEvoy M, 'Serum thiols and cardiovascular risk scores: a combined assessment of transsulfuration pathway components and substrate/product ratios', JOURNAL OF TRANSLATIONAL MEDICINE, 11 (2013) [C1]
DOI 10.1186/1479-5876-11-99
Citations Scopus - 7Web of Science - 7
Co-authors Mark Mcevoy
2013 Holliday S, Magin P, Dunbabin J, Oldmeadow C, Henry J-M, Lintzeris N, et al., 'An Evaluation of the Prescription of Opioids for Chronic Nonmalignant Pain by Australian General Practitioners', PAIN MEDICINE, 14 62-74 (2013) [C1]
DOI 10.1111/j.1526-4637.2012.01527.x
Citations Scopus - 13Web of Science - 11
Co-authors Parker Magin, A Dunlop, Christopher Oldmeadow
2013 Numthavaj P, Tanjararak K, Roongpuvapaht B, McEvoy M, Attia J, Thakkinstian A, 'Efficacy of Mitomycin C for postoperative endoscopic sinus surgery: a systematic review and meta-analysis', CLINICAL OTOLARYNGOLOGY, 38 198-207 (2013) [C1]
DOI 10.1111/coa.12114
Citations Scopus - 8Web of Science - 9
Co-authors Mark Mcevoy
2013 Talseth-Palmer B, Holliday EG, Evans T-J, McEvoy MA, Attia JR, Grice DM, et al., 'Continuing difficulties in interpreting CNV data: Lessons from a genome-wide CNV association study of Australian HNPCC/lynch syndrome patients', BMC Medical Genomics, 6 1-13 (2013) [C1]
Citations Scopus - 10Web of Science - 10
Co-authors Bente Talseth-Palmer, Mark Mcevoy, Liz Holliday, Rodney Scott
2013 Williams N, Hardy BM, Tarrant S, Enninghorst N, Attia J, Oldmeadow C, Balogh ZJ, 'Changes in hip fracture incidence, mortality and length of stay over the last decade in an Australian major trauma centre.', Archives of Osteoporosis, 8 (2013) [C1]
DOI 10.1007/s11657-013-0150-3
Citations Scopus - 14Web of Science - 14
Co-authors Christopher Oldmeadow, Zsolt Balogh
2013 Holliday EG, Magee CA, Kritharides L, Banks E, Attia J, 'Short Sleep Duration Is Associated with Risk of Future Diabetes but Not Cardiovascular Disease: a Prospective Study and Meta-Analysis', PLOS ONE, 8 (2013) [C1]
DOI 10.1371/journal.pone.0082305
Citations Scopus - 45Web of Science - 41
Co-authors Liz Holliday
2013 Mangoni AA, Zinellu A, Carru C, Attia JR, McEvoy M, 'Transsulfuration Pathway Thiols and Methylated Arginines: The Hunter Community Study', PLOS ONE, 8 (2013) [C1]
DOI 10.1371/journal.pone.0054870
Citations Scopus - 2Web of Science - 2
Co-authors Mark Mcevoy
2013 Islam MR, Arslan I, Attia J, McEvoy M, McElduff P, Basher A, et al., 'Is Serum Zinc Level Associated with Prediabetes and Diabetes?: A Cross-Sectional Study from Bangladesh', PLOS ONE, 8 (2013) [C1]
DOI 10.1371/journal.pone.0061776
Citations Scopus - 14Web of Science - 11
Co-authors Patrick Mcelduff, Mark Mcevoy, Milton Hasnat, Roseanne Peel
2013 McEvoy MA, Schofield PW, Smith WT, Agho K, Mangoni AA, Soiza RL, et al., 'Serum Methylarginines and Spirometry-Measured Lung Function in Older Adults', PLOS ONE, 8 (2013) [C1]
DOI 10.1371/journal.pone.0058390
Citations Scopus - 2Web of Science - 2
Co-authors Roseanne Peel, Wayne Smith, Peter Schofield, Mark Mcevoy
2013 Sun C, Young TL, Mackey DA, Van Zuydam NR, Doney ASF, Palmer CNA, et al., 'Genetic loci for retinal arteriolar microcirculation', PLoS One, 8 (2013) [C1]
DOI 10.1371/journal.pone.0065804
Citations Scopus - 6Web of Science - 8
Co-authors Liz Holliday, Rodney Scott
2013 Jensen RA, Sim X, Li X, Cotch MF, Ikram MK, Holliday EG, et al., 'Genome-wide association study of retinopathy in individuals without diabetes', PLoS One, 8 (2013) [C1]
DOI 10.1371/journal.pone.0054232
Citations Scopus - 6Web of Science - 6
Co-authors Rodney Scott, Liz Holliday
2013 Holliday EG, Smith AV, Cornes BK, Buitendijk GHS, Jensen RA, Sim X, et al., 'Insights into the genetic architecture of early stage age-related macular degeneration: A genome-wide association study meta-analysis', PLoS One, 8 (2013) [C1]
DOI 10.1371/journal.pone.0053830
Citations Scopus - 56Web of Science - 51
Co-authors Rodney Scott, Patrick Mcelduff, Liz Holliday
2013 Sukrat B, Wilasrusmee C, Siribumrungwong B, McEvoy M, Okascharoen C, Attia J, Thakkinstian A, 'Hemoglobin Concentration and Pregnancy Outcomes: A Systematic Review and Meta-Analysis', BIOMED RESEARCH INTERNATIONAL, 1-9 (2013) [C1]
DOI 10.1155/2013/769057
Citations Scopus - 10Web of Science - 6
Co-authors Mark Mcevoy
2012 Gogele M, Minelli C, Thakkinstian A, Yurkiewich A, Pattaro C, Pramstaller PP, et al., 'Methods for meta-analyses of genome-wide association studies: Critical assessment of empirical evidence', American Journal of Epidemiology, 175 739-749 (2012) [C1]
Citations Scopus - 28Web of Science - 26
2012 'Online-Only Abstracts', Colorectal Disease, 14 648-652 (2012)
DOI 10.1111/j.1463-1318.2012.03031.x
2012 Milne E, Greenop KR, Scott R, Bailey HD, Attia JR, Dalla-Pozza L, et al., 'Parental prenatal smoking and risk of childhood acute lymphoblastic leukemia', American Journal of Epidemiology, 175 43-53 (2012) [C1]
Citations Scopus - 53Web of Science - 46
Co-authors Rodney Scott
2012 Thakkinstian A, McEvoy MA, Chakravarthy U, Chakrabarti S, McKay GJ, Ryu E, et al., 'The association between complement component 2/complement factor B polymorphisms and age-related macular degeneration: A HuGE review and meta-analysis', American Journal of Epidemiology, 176 361-372 (2012) [C1]
Citations Scopus - 36Web of Science - 33
Co-authors Mark Mcevoy
2012 Wilasrusmee C, Sukrat B, McEvoy MA, Attia JR, Thakkinstian A, 'Systematic review and meta-analysis of safety of laparoscopic versus open appendicectomy for suspected appendicitis in pregnancy', British Journal of Surgery, 99 1470-1478 (2012) [C1]
Citations Scopus - 45Web of Science - 35
Co-authors Mark Mcevoy
2012 Vejakama P, Thakkinstian A, Attia JR, 'Renoprotective effects of renin-angiotensin-aldosterone system blockers in type 2 diabetes: Demystifying multiple treatment comparisons in a network meta-analysis. Reply', Diabetologia, 55 2549-2550 (2012) [C3]
2012 Vejakama P, Thakkinstian A, Lertrattananon D, Ingsathit A, Ngarmukos C, Attia JR, 'Reno-protective effects of renin-angiotensin system blockade in type 2 diabetic patients: A systematic review and network meta-analysis', Diabetologia, 55 566-578 (2012) [C1]
Citations Scopus - 66Web of Science - 64
2012 Courtney RJ, Paul CL, Sanson-Fisher RW, Macrae FA, Carey ML, Attia JR, McEvoy MA, 'Colorectal cancer screening in Australia: A community-level perspective', Medical Journal of Australia, 196 516-520 (2012) [C1]
DOI 10.5694/mja11.10661
Citations Scopus - 13Web of Science - 11
Co-authors Chris Paul, Rob Sanson-Fisher, Mariko Carey, Mark Mcevoy
2012 Murphy VE, Namazy JA, Powell H, Schatz M, Chambers C, Attia J, Gibson PG, 'A Meta-Analysis of Adverse Perinatal Outcomes in Women With Asthma EDITORIAL COMMENT', OBSTETRICAL & GYNECOLOGICAL SURVEY, 67 77-78 (2012) [C3]
DOI 10.1097/OGX.0b013e318247c54d
Co-authors Peter Gibson
2012 Hiles SA, Baker AL, De Malmanche T, Attia JR, 'Interleukin-6, C-reactive protein and interleukin-10 after antidepressant treatment in people with depression: A meta-analysis', Psychological Medicine, 42 2015-2026 (2012) [C1]
DOI 10.1017/S0033291712000128
Citations Scopus - 55Web of Science - 53
Co-authors Sarah Hiles, Amanda Baker
2012 Cheng YC, Anderson CD, Bione S, Keene K, Maguire JM, Nalls M, et al., 'Are myocardial infarction-associated single-nucleotide polymorphisms associated with ischemic stroke?', Stroke, 43 980-U143 (2012) [C1]
Citations Scopus - 16Web of Science - 17
Co-authors Pablo Moscato, Christopher Levi, Rodney Scott, Lisa Lincz, Liz Holliday
2012 Gupta SK, Lewis G, Rogers K, Attia JR, 'Quantitative Tc-99m DTPA renal transplant scintigraphy predicts graft survival in the very early postoperative period', Nuclear Medicine Communications, 33 1292-1299 (2012) [C1]
Citations Scopus - 5Web of Science - 6
2012 Suthers BG, Pickles RW, Boyle MJ, Nair BR, Cook J, Attia JR, 'The effect of context on performance of an acute medical unit: Experience from an Australian tertiary hospital', Australian Health Review, 36 320-324 (2012) [C1]
Citations Scopus - 3Web of Science - 5
2012 Bailey HD, Miller M, Langridge A, De Klerk NH, Van Bockxmeer FM, Attia JR, et al., 'Maternal dietary intake of folate and vitamins B6 and B12 during pregnancy and the risk of childhood acute lymphoblastic leukemia', Nutrition and Cancer, 64 1122-1130 (2012) [C1]
DOI 10.1080/01635581.2012.707278
Citations Scopus - 24Web of Science - 19
Co-authors Rodney Scott
2012 Suthers B, Hansbro PM, Thambar S, McEvoy MA, Peel R, Attia JR, 'Pneumococcal vaccination may induce anti-oxidized low-density lipoprotein antibodies that have potentially protective effects against cardiovascular disease', Vaccine, 30 3983-3985 (2012) [C1]
Citations Scopus - 7Web of Science - 8
Co-authors Mark Mcevoy, Philip Hansbro, Roseanne Peel
2012 Guest M, Boggess MM, Attia JR, 'Relative risk of elevated hearing threshold compared to ISO1999 normative populations for Royal Australian Air Force male personnel', Hearing Research, 285 65-76 (2012) [C1]
Citations Scopus - 5Web of Science - 5
Co-authors Catherine Deste
2012 Hiles SA, Baker AL, De Malmanche T, Attia JR, 'A meta-analysis of differences in IL-6 and IL-10 between people with and without depression: Exploring the causes of heterogeneity', Brain, Behavior, and Immunity, 26 1180-1188 (2012) [C1]
Citations Scopus - 81Web of Science - 78
Co-authors Amanda Baker, Sarah Hiles
2012 Woratanarat P, Angsanuntsukh C, Rattanasiri S, Attia JR, Woratanarat T, Thakkinstian A, 'Meta-analysis of pinning in supracondylar fracture of the humerus in children', Journal of Orthopaedic Trauma, 26 48-53 (2012) [C1]
Citations Scopus - 29Web of Science - 19
2012 Reid MG, Parkinson L, Gibson RE, Schofield PW, D'Este CA, Attia JR, et al., 'Memory Complaint Questionnaire performed poorly as screening tool: Validation against psychometric tests and affective measures', Journal of Clinical Epidemiology, 65 199-205 (2012) [C1]
Citations Scopus - 16Web of Science - 14
Co-authors Catherine Deste, Julie Byles, L Parkinson, Peter Schofield, Meredith Tavener
2012 Handley T, Inder KJ, Kelly BJ, Attia JR, Lewin TJ, Fitzgerald MN, Kay-Lambkin FJ, 'You've got to have friends: The predictive value of social integration and support in suicidal ideation among rural communities', Social Psychiatry and Psychiatric Epidemiology, 47 1281-1290 (2012) [C1]
Citations Scopus - 18Web of Science - 17
Co-authors Terry Lewin, Frances Kaylambkin, Kerry Inder, Brian Kelly
2012 Magee CA, Kritharides L, Attia JR, McElduff P, Banks E, 'Short and long sleep duration are associated with prevalent cardiovascular disease in Australian adults', Journal of Sleep Research, 21 441-447 (2012) [C1]
Citations Scopus - 36Web of Science - 29
Co-authors Patrick Mcelduff
2012 White JH, Gray KR, Magin PJ, Attia JR, Sturm J, Carter G, Pollack M, 'Exploring the experience of post-stroke fatigue in community dwelling stroke survivors: A prospective qualitative study', Disability and Rehabilitation, 34 1376-1384 (2012) [C1]
Citations Scopus - 23Web of Science - 21
Co-authors Parker Magin, Gregory Carter
2012 White JH, Miller B, Magin PJ, Attia JR, Sturm J, Pollack M, 'Access and participation in the community: A prospective qualitative study of driving post-stroke', Disability and Rehabilitation, 34 831-838 (2012) [C1]
Citations Scopus - 21Web of Science - 20
Co-authors Parker Magin
2012 Collins NJ, Hatton R, Ng K, Bhagwandeen R, Attia JR, Oldmeadow CJ, Jayasinghe R, 'Percutaneous device closure of patent foramen ovale using the premere occlusion device: Initial experience, procedural, and intermediate-term results', Journal of Invasive Cardiology, 24 164-168 (2012) [C1]
Citations Scopus - 3Web of Science - 2
Co-authors Christopher Oldmeadow
2012 Bellenguez C, Bevan S, Gschwendtner A, Spencer CCA, Burgess AI, Pirinen M, et al., 'Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke', Nature Genetics, 44 328-333 (2012) [C1]
DOI 10.1038/ng.1081
Citations Scopus - 207Web of Science - 175
Co-authors Liz Holliday, Christopher Levi
2012 Nyholt DR, Low S-K, Anderson CA, Painter JN, Uno S, Morris AP, et al., 'Genome-wide association meta-analysis identifies new endometriosis risk loci', Nature Genetics, 44 1355-1359 (2012) [C1]
Citations Scopus - 120Web of Science - 102
Co-authors Liz Holliday, Mark Mcevoy, Rodney Scott
2012 Holliday EG, Maguire JM, Evans T-J, Koblar SA, Jannes J, Sturm J, et al., 'Common variants at 6p21.1 are associated with large artery atherosclerotic stroke', Nature Genetics, 44 1147-1153 (2012) [C1]
Citations Scopus - 86Web of Science - 80
Co-authors Mark Mcevoy, Christopher Oldmeadow, Christopher Levi, Roseanne Peel, Mark Parsons, Pablo Moscato, Wayne Smith, Lisa Lincz, Rodney Scott, Liz Holliday
2012 Okada Y, Sim X, Go MJ, Wu J-Y, Gu D, Takeuchi F, et al., 'Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations', Nature Genetics, 44 904-909 (2012) [C1]
Citations Scopus - 89Web of Science - 91
Co-authors Liz Holliday, Rodney Scott, Christopher Oldmeadow
2012 Siribumrungwong B, Noorit P, Wilasrusmee C, Attia JR, Thakkinstian A, 'A systematic review and meta-analysis of randomised controlled trials comparing endovenous ablation and surgical intervention in patients with varicose vein', European Journal of Vascular and Endovascular Surgery, 44 214-233 (2012) [C1]
Citations Scopus - 81Web of Science - 65
2012 Lechner-Scott J, Spencer B, De Malmanche T, Attia JR, Fitzgerald M, Trojano M, et al., 'The frequency of CSF oligoclonal banding in multiple sclerosis increases with latitude', Multiple Sclerosis Journal, 18 974-982 (2012) [C1]
DOI 10.1177/1352458511431729
Citations Scopus - 29Web of Science - 22
Co-authors Jeannette Lechner-Scott
2012 Jackson N, Barlow M, Leitch J, Attia JR, 'Treating atrial fibrillation: Pulmonary vein isolation with the cryoballoon technique', Heart Lung and Circulation, 21 427-432 (2012) [C1]
Citations Scopus - 11Web of Science - 7
2012 Hiew C, Duggan A, De Malmanche T, Hatton R, Baker FA, Attia JR, Collins N, 'Prevalence of Helicobacter pylori positivity in patients undergoing percutaneous coronary intervention', Internal Medicine Journal, 42 289-293 (2012) [C1]
DOI 10.1111/j.1445-5994.2010.02260.x
Citations Scopus - 3Web of Science - 3
2012 Courtney RJ, Paul CL, Sanson-Fisher RW, Macrae F, Attia JR, McEvoy MA, 'Current state of medical-advice-seeking behaviour for symptoms of colorectal cancer: determinants of failure and delay in medical consultation', Colorectal Disease, 14 e222-e229 (2012) [C1]
Citations Scopus - 14Web of Science - 9
Co-authors Chris Paul, Mark Mcevoy, Rob Sanson-Fisher
2012 Thakkinstian A, Attia JR, Anothaisintawee T, Nickel JC, 'a-blockers, antibiotics and anti-inflammatories have a role in the management of chronic prostatitis/chronic pelvic pain syndrome', BJU International, 110 1014-1022 (2012) [C1]
Citations Scopus - 30Web of Science - 23
2012 Murphy VE, Namazy JA, Powell H, Schatz M, Chambers C, Attia JR, Gibson PG, 'Severity of asthma in pregnancy affects perinatal outcomes - Authors' Reply', BJOG - An International Journal of Obstetrics and Gynaecology, 119 508-509 (2012) [C3]
DOI 10.1111/j.1471-0528.2011.03258.x
Citations Scopus - 1Web of Science - 1
Co-authors Vanessa Murphy, Peter Gibson
2012 Courtney RJ, Paul CL, Sanson-Fisher RW, Macrae FA, Carey ML, Attia JR, McEvoy MA, 'Colorectal cancer risk assessment and screening recommendation: A community survey of healthcare providers' practice from a patient perspective', BMC Family Practice, 13 1-9 (2012) [C1]
Citations Scopus - 4Web of Science - 3
Co-authors Chris Paul, Mariko Carey, Mark Mcevoy, Rob Sanson-Fisher
2012 Courtney RJ, Paul CL, Sanson-Fisher RW, Macrae FA, Attia JR, McEvoy MA, 'Factors associated with consultation behaviour for primary symptoms potentially indicating colorectal cancer: A cross-sectional study on response to symptoms', BMC Gastroenterology, 12 1-9 (2012) [C1]
Citations Scopus - 9Web of Science - 8
Co-authors Rob Sanson-Fisher, Mark Mcevoy, Chris Paul
2012 Gwynn JD, Flood VM, D'Este CA, Attia JR, Turner N, Cochrane J, et al., 'Poor food and nutrient intake among Indigenous and non-Indigenous rural Australian children', BMC Pediatrics, 12 1-14 (2012) [C1]
Citations Scopus - 11Web of Science - 11
Co-authors John Wiggers, Catherine Deste, Josephine Gwynn
2012 Handley T, Inder KJ, Kay-Lambkin FJ, Stain HJ, Fitzgerald M, Lewin TJ, et al., 'Contributors to suicidality in rural communities: Beyond the effects of depression', BMC Psychiatry, 12 105 (2012) [C1]
Citations Scopus - 17Web of Science - 16
Co-authors Helen Stain, Kerry Inder, Frances Kaylambkin, Terry Lewin, Brian Kelly
2012 Allen J, Inder KJ, Lewin TJ, Attia JR, Kelly BJ, 'Social support and age influence distress outcomes differentially across urban, regional and remote Australia: An exploratory study', BMC Public Health, 12 928 (2012) [C1]
Citations Scopus - 13Web of Science - 13
Co-authors Brian Kelly, Terry Lewin, Kerry Inder
2012 Thomas L, Rivett DA, Attia JR, Levi CR, 'Risk factors and clinical presentation of craniocervical arterial dissection: A prospective study', BMC Musculoskeletal Disorders, 13 1-6 (2012) [C3]
Co-authors Darren Rivett, Christopher Levi, Lucy Thomas
2012 Robertson J, McElduff P, Pearson S-A, Henry DA, Inder KJ, Attia JR, 'The health services burden of heart failure: An analysis using linked population health data-sets', BMC Health Services Research, 12 1-11 (2012) [C1]
Citations Scopus - 21Web of Science - 22
Co-authors Patrick Mcelduff, Kerry Inder
2012 Islam MR, Khan I, Hassan SMN, McEvoy MA, D'Este CA, Attia JR, et al., 'Association between type 2 diabetes and chronic arsenic exposure in drinking water: A cross sectional study in Bangladesh', Environmental Health, 11 1-8 (2012) [C1]
Citations Scopus - 35Web of Science - 10
Co-authors Catherine Deste, Mark Mcevoy, Milton Hasnat, Roseanne Peel
2012 Dudding TE, Attia JR, 'Maternal factor V Leiden and adverse pregnancy outcome: Deciding whether or not to test', Journal of Maternal-Fetal & Neonatal Medicine, 25 889-894 (2012) [C1]
Citations Scopus - 4Web of Science - 2
Co-authors T Dudding
2012 White JH, Magin PJ, Attia JR, Sturm J, Carter GL, Pollack M, 'Trajectories of psychological distress after stroke', Annals of Family Medicine, 10 435-442 (2012) [C1]
Citations Scopus - 18Web of Science - 15
Co-authors Gregory Carter, Parker Magin
2012 Islam MR, Khan I, Attia JR, Hassan SMN, McEvoy MA, D'Este CA, et al., 'Association between hypertension and chronic arsenic exposure in drinking water: A cross-sectional study in Bangladesh', International Journal of Environmental Research and Public Health, 9 4522-4536 (2012) [C1]
Citations Scopus - 18Web of Science - 13
Co-authors Catherine Deste, Mark Mcevoy, Milton Hasnat
2011 Numthavaj P, Thakkinstian A, Dejthevaporn C, Attia JR, 'Corticosteroid and antiviral therapy for Bell's palsy: A network meta-analysis', BMC Neurology, 11 1 (2011) [C1]
DOI 10.1186/1471-2377-11-1
Citations Scopus - 28Web of Science - 26
2011 Moxey AJ, McEvoy MA, Bowe SJ, Attia JR, 'Spirituality, religion, social support and health among older Australian adults', Australasian Journal on Ageing, 30 82-88 (2011) [C1]
DOI 10.1111/j.1741-6612.2010.00453.x
Citations Scopus - 13Web of Science - 12
Co-authors Mark Mcevoy
2011 Kypri K, McCambridge J, Wilson AJ, Attia JR, Sheeran P, Bowe S, Vater T, 'Effects of study design and allocation on participant behaviour- ESDA: Study protocol for a randomized controlled trial', Trials, 12 42 (2011) [C3]
DOI 10.1186/1745-6215-12-42
Citations Scopus - 18Web of Science - 18
Co-authors Amanda Wilson, Kypros Kypri
2011 Thakkinstian A, McKay GJ, McEvoy MA, Chakravarthy U, Chakrabarti S, Silvestri G, et al., 'Systematic review and meta-analysis of the association between complement component 3 and age-related macular degeneration: A HuGE review and meta-analysis', American Journal of Epidemiology, 173 1365-1379 (2011) [C1]
DOI 10.1093/aje/kwr025
Citations Scopus - 73Web of Science - 67
Co-authors Mark Mcevoy
2011 Thompson JR, Attia JR, Minelli C, 'The meta-analysis of genome-wide association studies', Briefings in Bioinformatics, 12 259-269 (2011) [C1]
DOI 10.1093/bib/bbr020
Citations Scopus - 36Web of Science - 33
2011 Anothaisintawee T, Attia J, Nickel JC, Thammakraisorn S, Numthavaj P, McEvoy M, Thakkinstian A, 'Management of chronic prostatitis/chronic pelvic pain syndrome: A systematic review and network meta-analysis', Journal of Urology, 186 546-547 (2011)
DOI 10.1016/j.juro.2011.04.035
Co-authors Mark Mcevoy
2011 Reid A, Glass DC, Bailey HD, Milne E, de Klerk NH, Downie P, Fritschi L, 'Risk of childhood acute lymphoblastic leukaemia following parental occupational exposure to extremely low frequency electromagnetic fields', BRITISH JOURNAL OF CANCER, 105 1409-1413 (2011) [C1]
DOI 10.1038/bjc.2011.365
Citations Scopus - 10Web of Science - 6
2011 Bailey HD, Milne E, De Klerk NH, Fritschi L, Attia JR, Cole C, Armstrong BK, 'Exposure to house painting and the use of floor treatments and the risk of childhood acute lymphoblastic leukemia', International Journal of Cancer, 128 2405-2414 (2011) [C1]
DOI 10.1002/ijc.25572
Citations Scopus - 15Web of Science - 13
2011 Bailey HD, Armstrong BK, De Klerk NH, Fritschi L, Attia JR, Scott R, et al., 'Exposure to professional pest control treatments and the risk of childhood acute lymphoblastic leukemia', International Journal of Cancer, 129 1678-1688 (2011) [C1]
Citations Scopus - 18Web of Science - 17
Co-authors Rodney Scott
2011 Ongugo K, Hall JJ, Attia JR, 'Implementing tuberculosis control in Papua New Guinea: A clash of culture and science?', Journal of Community Health, 36 423-430 (2011) [C1]
DOI 10.1007/s10900-010-9324-8
Citations Scopus - 7Web of Science - 7
Co-authors John Hall
2011 Thakkinstian A, Attia JR, 'Treatment of chronic prostatitis/chronic pelvic pain syndrome - Reply', JAMA - Journal of the American Medical Association, 305 1298-1299 (2011) [C3]
2011 Anothaisintawee T, Attia JR, Nickel JC, Thammakraisorn S, Numthavaj P, McEvoy MA, Thakkinstian A, 'Management of chronic prostatitis/ Chronic pelvic pain syndrome: A systematic review and network meta-analysis', JAMA: The Journal of the American Medical Association, 305 78-86 (2011) [C1]
DOI 10.1001/jama.2010.1913
Citations Scopus - 111Web of Science - 83
Co-authors Mark Mcevoy
2011 Ngamjanyaporn P, Thakkinstian A, Verasertniyom O, Chatchaipun P, Vanichapuntu M, Nantiruj K, et al., 'Pharmacogenetics of cyclophosphamide and CYP2C19 polymorphism in Thai systemic lupus erythematosus', Rheumatology International, 31 1215-1218 (2011) [C1]
DOI 10.1007/s00296-010-1420-7
Citations Scopus - 10Web of Science - 7
2011 Bailey HD, De Klerk NH, Fritschi L, Attia JR, Daubenton JD, Armstrong BK, Milne E, 'Refuelling of vehicles, the use of wood burners and the risk of acute lymphoblastic leukaemia in childhood', Paediatric and Perinatal Epidemiology, 25 528-539 (2011) [C1]
Citations Scopus - 7Web of Science - 6
2011 Guest M, D'Este CA, Attia JR, Boggess M, Brown A, Tavener M, et al., 'Impairment of color vision in aircraft maintenance workers', International Archives of Occupational and Environmental Health, 84 723-733 (2011) [C1]
DOI 10.1007/s00420-010-0600-9
Citations Scopus - 4Web of Science - 3
Co-authors Catherine Deste, Meredith Tavener
2011 Osmotherly PG, McElduff P, Attia JR, 'Factor Structure of the Neck Disability Index RESPONSE', SPINE, 36 1816-1816 (2011) [C3]
DOI 10.1097/BRS.0b013e31822b4321
Co-authors Patrick Mcelduff, Peter Osmotherly
2011 Pickering PM, Osmotherly PG, Attia JR, McElduff P, 'An examination of outcome measures for pain and dysfunction in the cervical spine: A factor analysis', Spine, 36 581-588 (2011) [C1]
DOI 10.1097/brs.0b013e3181d762da
Citations Scopus - 19Web of Science - 17
Co-authors Patrick Mcelduff, Peter Osmotherly
2011 Osmotherly PG, McElduff P, Attia JR, 'In response: Factor structure of the Neck Disability Index', Spine, 36 1816 (2011) [C3]
Co-authors Patrick Mcelduff, Peter Osmotherly
2011 Oldmeadow CJ, Riveros RC, Holliday EG, Scott R, Moscato PA, Wang JJ, et al., 'Sifting the wheat from the chaff: Prioritizing GWAS results by identifying consistency across analytical methods', Genetic Epidemiology, 35 745-754 (2011) [C1]
DOI 10.1002/gepi.20622
Citations Scopus - 8Web of Science - 7
Co-authors Carlos Riveros, Christopher Oldmeadow, Pablo Moscato, Liz Holliday, Rodney Scott
2011 Milne E, Royle JA, Bennett LC, De Klerk NH, Bailey HD, Bower C, et al., 'Maternal consumption of coffee and tea during pregnancy and risk of childhood ALL: Results from an Australian case-control study', Cancer Causes & Control, 22 207-218 (2011) [C1]
DOI 10.1007/s10552-010-9688-1
Citations Scopus - 14Web of Science - 12
Co-authors Rodney Scott
2011 Bryant JL, Bonevski B, Paul CL, McElduff P, Attia JR, 'A systematic review and meta-analysis of the effectiveness of behavioural smoking cessation interventions in selected disadvantaged groups', Addiction, 106 1568-1585 (2011) [C1]
DOI 10.1111/j.1360-0443.2011.03467.x
Citations Scopus - 47Web of Science - 48
Co-authors Patrick Mcelduff, Chris Paul, Amanda Wilson, Billie Bonevski
2011 Guest M, Boggess MM, D'Este CA, Attia JR, Brown A, 'An observed relationship between vestibular function and auditory thresholds in aircraft-maintenance workers', Journal of Occupational and Environmental Medicine, 53 146-152 (2011) [C1]
DOI 10.1097/jom.0b013e318204fa7f
Citations Scopus - 4Web of Science - 4
Co-authors Catherine Deste
2011 Guest M, Attia JR, D'Este CA, Boggess MM, Brown AM, Gibson RE, et al., 'Peripheral neuropathy in military aircraft maintenance workers in Australia', Journal of Occupational and Environmental Medicine, 53 381-387 (2011) [C1]
DOI 10.1097/jom.0b013e318212226d
Co-authors Meredith Tavener, Catherine Deste
2011 Handley T, Inder KJ, Kelly BJ, Attia JR, Kay-Lambkin FJ, 'Urban-rural influences on suicidality: Gaps in the existing literature and recommendations for future research', Australian Journal of Rural Health, 19 279-283 (2011) [C1]
DOI 10.1111/j.1440-1584.2011.01235.x
Citations Scopus - 6Web of Science - 5
Co-authors Frances Kaylambkin, Kerry Inder, Brian Kelly
2011 Maguire JM, Thakkinstian A, Levi CR, Lincz L, Bisset L, Sturm J, et al., 'Impact of COX-2 rs5275 and rs20417 and GPIIIa rs5918 polymorphisms on 90-day ischemic stroke functional outcome: A novel finding', Journal of Stroke and Cerebrovascular Diseases, 20 134-144 (2011) [C1]
DOI 10.1016/j.jstrokecerebrovasdis.2009.10.011
Citations Scopus - 31Web of Science - 31
Co-authors Rodney Scott, Lisa Lincz, Christopher Levi
2011 McKay GJ, Patterson CC, Chakravarthy U, Dasari S, Klaver CC, Vingerling JR, et al., 'Evidence of association of APOE with age-related macular degeneration - A pooled analysis of 15 studies', Human Mutation, 32 1407-1416 (2011) [C1]
Citations Scopus - 56Web of Science - 48
2011 Khor CC, Davila S, Breunis WB, Lee YC, Shimizu C, Wright VJ, et al., 'Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease', Nature Genetics, 43 1241-1248 (2011) [C1]
Citations Scopus - 138Web of Science - 126
Co-authors Liz Holliday, Rodney Scott
2011 Thomas L, Rivett DA, Attia JR, Parsons MW, Levi CR, 'Risk factors and clinical features of craniocervical arterial dissection', Manual Therapy, 16 351-356 (2011) [C1]
DOI 10.1016/j.math.2010.12.008
Citations Scopus - 31Web of Science - 30
Co-authors Christopher Levi, Lucy Thomas, Mark Parsons, Darren Rivett
2011 Jones LJ, Craven P, Attia JR, Thakkinstian A, Wright IM, 'Network meta-analysis of indomethacin versus ibuprofen versus placebo for PDA in preterm infants', Archives of Disease in Childhood-Fetal and Neonatal Edition, 96 F45-F52 (2011) [C1]
DOI 10.1136/adc.2009.168682
Citations Scopus - 45Web of Science - 41
Co-authors Ian Wright
2011 McGettigan P, Lincz L, Attia JR, McElduff P, Bissett L, Peel R, et al., 'The risk of coronary thrombosis with cyclo-oxygenase-2 inhibitors does not vary with polymorphisms in two regions of the cyclo-oxygenase-2 gene', British Journal of Clinical Pharmacology, 72 707-714 (2011) [C1]
DOI 10.1111/j.1365-2125.2011.03957.x
Citations Scopus - 7Web of Science - 8
Co-authors Patrick Mcelduff, Roseanne Peel, Lisa Lincz, Mddah01, Barrie Stokes
2011 Gwynn JD, Flood VM, D'Este CA, Attia JR, Turner N, Cochrane J, Wiggers JH, 'The reliability and validity of a short FFQ among Australian Aboriginal and Torres Strait Islander and non-Indigenous rural children', Public Health Nutrition, 14 388-401 (2011) [C1]
DOI 10.1017/s1368980010001928
Citations Scopus - 16Web of Science - 14
Co-authors John Wiggers, Josephine Gwynn, Catherine Deste
2011 Nair BR, Heim C, Krishnan C, D'Este CA, Marley J, Attia JR, 'The effect of Baroque music on behavioural disturbances in patients with dementia', Australasian Journal on Ageing, 30 11-15 (2011) [C1]
DOI 10.1111/j.1741-6612.2010.00439.x
Citations Scopus - 13Web of Science - 7
Co-authors Catherine Deste
2011 Ranasinghe WKB, Wright TA, Attia JR, McElduff P, Doyle T, Bartholomew M, et al., 'Effects of bariatric surgery on urinary and sexual function', BJU International, 107 88-94 (2011) [C1]
DOI 10.1111/j.1464-410x.2010.09509.x
Citations Scopus - 25Web of Science - 19
Co-authors Patrick Mcelduff
2011 Murphy VE, Namazy JA, Powell H, Schatz M, Chambers C, Attia JR, Gibson PG, 'A meta-analysis of adverse perinatal outcomes in women with asthma', BJOG: An International Journal of Obstetrics and Gynaecology, 118 1314-1323 (2011) [C1]
DOI 10.1111/j.1471-0528.2011.03055.x
Citations Scopus - 119Web of Science - 110
Co-authors Vanessa Murphy, Peter Gibson
2010 Lees KR, Bluhmki E, Von Kummer R, Brott TG, Toni D, Grotta JC, et al., 'Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials', The Lancet, 375 1695-1703 (2010) [C1]
DOI 10.1016/S0140-6736(10)60491-6
Citations Scopus - 1081Web of Science - 977
Co-authors Mark Parsons, Christopher Levi
2010 Tran HA, Reeves GEM, Lyons TJ, Attia JR, 'Histopathologic findings of autoimmunity in thyroid, pituitary, and adrenal diseases in chronic Hepatitis C postmortem cases', Endocrine Practice, 16 566-569 (2010) [C1]
DOI 10.4158/EP09359.OR
Citations Scopus - 1Web of Science - 1
2010 Attia JR, Thakkinstian A, McElduff P, Milne E, Dawson S, Scott R, et al., 'Detecting genotyping error using measures of degree of Hardy-Weinberg disequilibrium', Statistical Applications in Genetics and Molecular Biology, 9 17 (2010) [C1]
DOI 10.2202/1544-6115.1463
Citations Scopus - 12Web of Science - 6
Co-authors Patrick Mcelduff, Rodney Scott
2010 Janssen H, Bernhardt J, Collier JM, Sena ES, McElduff P, Attia JR, et al., 'An enriched environment improves sensorimotor function post-ischemic stroke', Neurorehabilitation and Neural Repair, 24 802-813 (2010) [C1]
DOI 10.1177/1545968310372092
Citations Scopus - 51Web of Science - 46
Co-authors Patrick Mcelduff, Michael Nilsson, Neil Spratt
2010 Ikram MK, Xueling S, Jensen RA, Cotch MF, Hewitt AW, Ikram MA, et al., 'Four Novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation In Vivo', Plos Genetics, 6 1-12 (2010) [C1]
DOI 10.1371/journal.pgen.1001184
Citations Scopus - 71Web of Science - 69
Co-authors Liz Holliday, Rodney Scott
2010 Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, Gilbert M, et al., 'Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk', Cancer Epidemiology, 34 328-337 (2010) [C1]
DOI 10.1016/j.canep.2010.03.005
Citations Scopus - 37Web of Science - 38
Co-authors Ian Symonds, Mark Mcevoy, Rodney Scott
2010 Wang JJ, Attia JR, 'Study Designs in Epidemiology and Levels of Evidence', American Journal of Ophthalmology, 149 367-370 (2010) [C2]
Citations Scopus - 7Web of Science - 6
2010 Holliday EG, Scott R, Attia JR, 'Evidence-based medicine in the era of biomarkers: Teaching a new dog old tricks?', Clinical Pharmacology and Therapeutics, 88 740-742 (2010) [C2]
DOI 10.1038/clpt.2010.214
Citations Scopus - 5Web of Science - 3
Co-authors Rodney Scott, Liz Holliday
2010 Smith DR, Attia JR, McEvoy MA, 'Exploring new frontiers in occupational epidemiology: The Hunter Community Study (HCS) from Australia', Industrial Health, 48 244-248 (2010) [C1]
DOI 10.2486/indhealth.48.244
Citations Scopus - 6Web of Science - 6
Co-authors Mark Mcevoy
2010 Milne E, Royle JA, Miller M, Bower C, De Klerk NH, Bailey HD, et al., 'Maternal folate and other vitamin supplementation during pregnancy and risk of acute lymphoblastic leukemia in the offspring', International Journal of Cancer, 126 2690-2699 (2010) [C1]
DOI 10.1002/ijc.24969
Citations Scopus - 45Web of Science - 36
Co-authors Rodney Scott
2010 Schofield PW, Lee SJ, Lewin TJ, Lyall G, Moyle J, Attia JR, McEvoy MA, 'The Audio Recorded Cognitive Screen (ARCS): A flexible hybrid cognitive test instrument', Journal of Neurology Neurosurgery and Psychiatry, 81 602-607 (2010) [C1]
DOI 10.1136/jnnp.2009.188003
Citations Scopus - 19Web of Science - 18
Co-authors Terry Lewin, Peter Schofield, Mark Mcevoy
2010 Kamanamool N, McEvoy MA, Attia JR, Ingsathit A, Ngamjanyaporn P, Thakkinstian A, 'Efficacy and adverse events of mycophenolate mofetil versus cyclophosphamide for induction therapy of lupus nephritis: Systematic review and meta-analysis', Medicine, 89 227-235 (2010) [C1]
DOI 10.1097/MD.0b013e3181e93d00
Citations Scopus - 43Web of Science - 36
Co-authors Mark Mcevoy
2010 Lemmens R, Buysschaert I, Geelen V, Fernandez-Cadenas I, Montaner J, Schmidt H, et al., 'The Association of the 4q25 susceptibility variant for atrial fibrillation with stroke is limited to stroke of cardioembolic etiology', Stroke, 41 1850-1857 (2010) [C1]
DOI 10.1161/STROKEAHA.110.587980
Citations Scopus - 41Web of Science - 44
Co-authors Christopher Levi
2010 Limsuwan T, Thakkinstian A, Verasertniyom O, Vanichapuntu M, Attia JR, Janwityanujit S, Nantiruj K, 'Possible protective effects of the Glu27 allele of beta(2)-Adrenergic receptor polymorphism in Thai asthmatic patients', Asian Pacific Journal of Allergy and Immunology, 28 107-114 (2010) [C1]
Citations Scopus - 4Web of Science - 2
2010 Bailey HD, Milne E, De Klerk N, Fritschi L, Bower C, Attia JR, Armstrong BK, 'Representativeness of child controls recruited by random digit dialling', Paediatric and Perinatal Epidemiology, 24 293-302 (2010) [C1]
DOI 10.1111/j.1365-3016.2010.01099.x
Citations Scopus - 29Web of Science - 28
2010 Guest M, Boggess M, Attia JR, D'Este CA, Brown A, Gibson RE, et al., 'Hearing impairment in F-111 maintenance workers: The study of health outcomes in aircraft maintenance personnel (SHOAMP) general health and medical study', American Journal of Industrial Medicine, 53 1159-1169 (2010) [C1]
DOI 10.1002/ajim.20867
Citations Scopus - 10Web of Science - 9
Co-authors Catherine Deste, Meredith Tavener
2010 McEvoy MA, Smith WT, D'Este CA, Duke JM, Peel R, Schofield PW, et al., 'Cohort Profile: The Hunter Community Study', International Journal of Epidemiology, 39 1452-1463 (2010) [C1]
DOI 10.1093/ije/dyp343
Citations Scopus - 72Web of Science - 73
Co-authors Wayne Smith, Ben Ewald, Catherine Deste, Mddah01, Rodney Scott, Roseanne Peel, Julie Byles, Peter Schofield, Mark Mcevoy
2010 Ewald BD, McEvoy MA, Attia JR, 'Pedometer counts superior to physical activity scale for identifying health markers in older adults', British Journal of Sports Medicine, 44 756-761 (2010) [C1]
DOI 10.1136/bjsm.2008.048827
Citations Scopus - 22Web of Science - 17
Co-authors Mark Mcevoy, Ben Ewald
2010 Wood LG, Attia JR, McElduff P, McEvoy MA, Gibson PG, 'Assessment of dietary fat intake and innate immune activation as risk factors for impaired lung function', European Journal of Clinical Nutrition, 64 818-825 (2010) [C1]
DOI 10.1038/ejcn.2010.68
Citations Scopus - 7Web of Science - 7
Co-authors Peter Gibson, Lisa Wood, Mark Mcevoy, Patrick Mcelduff
2010 Marsden DL, Spratt NJ, Walker R, Barker DJ, Attia JR, Pollack MR, et al., 'Trends in stroke attack rates and case fatality in the Hunter Region, Australia 1996-2008', Cerebrovascular Diseases, 30 500-507 (2010) [C1]
DOI 10.1159/000319022
Citations Scopus - 21Web of Science - 22
Co-authors Neil Spratt, Mark Parsons, Christopher Levi
2010 Hiew C, Williams T, Hatton R, Narasimhan S, O'Connor S, Baker F, et al., 'Influence of age on long-term outcome after emergent percutaneous coronary intervention for ST-elevation myocardial infarction', Journal of Invasive Cardiology, 22 273-277 (2010) [C1]
Citations Scopus - 8Web of Science - 7
Co-authors Patrick Mcelduff, Seshasayee Narasimhan
2010 Bailey HD, Armstrong BK, De Klerk NH, Fritschi L, Attia JR, Lockwood L, et al., 'Exposure to Diagnostic Radiological Procedures and the Risk of Childhood Acute Lymphoblastic Leukemia', Cancer Epidemiology Biomarkers & Prevention, 19 2897-2909 (2010) [C1]
DOI 10.1158/1055-9965.EPI-10-0542
Citations Scopus - 16Web of Science - 11
2010 Gwynn JD, Hardy LL, Wiggers JH, Smith WT, D'Este CA, Turner N, et al., 'The validation of a self-report measure and physical activity of Australian Aboriginal and Torres Strait Islander and non-Indigenous rural children', Australian and New Zealand Journal of Public Health, 34 S57-S65 (2010) [C1]
DOI 10.1111/j.1753-6405.2010.00555.x
Citations Scopus - 14Web of Science - 11
Co-authors Wayne Smith, Catherine Deste, John Wiggers, Josephine Gwynn
2010 Arj-Ong S, Thakkinstian A, McEvoy MA, Attia JR, 'A systematic review and meta-analysis of tumor necrosis factor alpha-308 polymorphism and Kawasaki disease', Pediatrics International, 52 527-532 (2010) [C1]
DOI 10.1111/j.1442-200X.2010.03105.x
Citations Scopus - 13Web of Science - 11
Co-authors Mark Mcevoy
2010 Gupta SK, McGrath S, Rogers K, Attia JR, Lewis G, Viswanathan S, et al., 'Fixed dose (555 MBq; 15 mCi) radioiodine for the treatment of hyperthyroidism: outcome and its predictors', Internal Medicine Journal, 40 854-857 (2010) [C1]
DOI 10.1111/j.1445-5994.2010.02348.x
Citations Scopus - 9Web of Science - 7
2010 Ashton KA, Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, Scott R, 'Toll-Like Receptor (TLR) and Nucleosome-binding Oligomerization Domain (NOD) gene polymorphisms and endometrial cancer risk', BMC Cancer, 10 1-7 (2010) [C1]
DOI 10.1186/1471-2407-10-382
Citations Scopus - 31Web of Science - 28
Co-authors Rodney Scott, Ian Symonds, Mark Mcevoy
2010 Loten C, Attia JR, Hullick C, Marley J, McElduff P, 'Point of care troponin decreases time in the emergency department for patients with possible acute coronary syndrome: A randomised controlled trial', Emergency Medicine Journal, 27 194-198 (2010) [C1]
DOI 10.1136/emj.2008.069427
Citations Scopus - 21Web of Science - 18
Co-authors Patrick Mcelduff
2009 Ashton KA, Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, et al., 'Estrogen receptor polymorphisms and the risk of endometrial cancer', BJOG: An International Journal of Obstetrics and Gynaecology, 116 1053-1061 (2009) [C1]
DOI 10.1111/j.1471-0528.2009.02185.x
Citations Scopus - 36Web of Science - 34
Co-authors Ian Symonds, Mark Mcevoy, Rodney Scott
2009 Loten C, Attia JR, Hullick C, Marley J, McElduff P, 'Validation of a point of care troponin assay in real life emergency department conditions', Emergency Medicine Australasia, 21 286-292 (2009) [C1]
DOI 10.1111/j.1742-6723.2009.01198.x
Citations Scopus - 7Web of Science - 6
Co-authors Patrick Mcelduff
2009 Loten C, Isbister GK, Jamcotchian MA, Hullick C, McElduff P, Attia JR, Marley J, 'Adverse outcomes following emergency department discharge of patients with possible acute coronary syndrome', Emergency Medicine Australasia, 21 455-464 (2009) [C1]
DOI 10.1111/j.1742-6723.2009.01229.x
Citations Scopus - 7Web of Science - 8
Co-authors Geoffrey Isbister, Patrick Mcelduff
2009 Brown A, Gibson RE, Tavener MA, Guest M, D'Este CA, Byles JE, et al., 'Sexual function in F-111 maintenance workers: The study of health outcomes in aircraft maintenance personnel', Journal of Sexual Medicine, 6 1569-1578 (2009) [C1]
DOI 10.1111/j.1743-6109.2009.01237.x
Citations Scopus - 3Web of Science - 3
Co-authors Catherine Deste, Meredith Tavener, Julie Byles
2009 Milne E, Royle JA, De Klerk NH, Blair E, Bailey H, Cole C, et al., 'Fetal growth and risk of childhood acute lymphoblastic leukemia: Results from an Australian case-control study', American Journal of Epidemiology, 170 221-228 (2009) [C1]
DOI 10.1093/aje/kwp117
Citations Scopus - 30Web of Science - 27
Co-authors Rodney Scott
2009 Minelli C, Thompson JR, Abrams KR, Thakkinstian A, Attia JR, 'The quality of meta-analyses of Genetic Association Studies: A veview with recommendations', American Journal of Epidemiology, 170 1333-1343 (2009) [C1]
DOI 10.1093/aje/kwp350
Citations Scopus - 27Web of Science - 26
2009 Miles S, Rogers KM, Thomas P, Soans B, Attia JR, Abel C, et al., 'A comparison of single-photon emission CT lung scintigraphy and CT pulmonary angiography for the diagnosis of pulmonary embolism', Chest, 136 1546-1553 (2009) [C1]
DOI 10.1378/chest.09-0361
Citations Scopus - 53Web of Science - 43
Co-authors Catherine Deste, Michael Hensley
2009 McCambridge J, Kypri K, Attia JR, Elbourne D, 'Re: Promoting regular mammography screening I: A systematic assessment of validity in a randomized trial', Journal of the National Cancer Institute, 101 1029-1030 (2009) [C3]
DOI 10.1093/jnci/djp154
Citations Scopus - 2Web of Science - 2
Co-authors Kypros Kypri
2009 Parsons MW, Miteff F, Bateman GA, Spratt NJ, Loiselle A, Attia JR, Levi CR, 'Acute ischemic stroke imaging-guided tenecteplase treatment in an extended time window', Neurology, 72 915-921 (2009) [C1]
DOI 10.1212/01.wnl.0000344168.05315.9d
Citations Scopus - 77Web of Science - 67
Co-authors Mark Parsons, Christopher Levi, Neil Spratt
2009 Hallinan R, Crettol S, Agho K, Attia JR, Besson J, Croquette-Krokar M, et al., 'Cannabis and benzodiazepines as determinants of methadone trough plasma concentration variability in maintenance treatment: A transnational study', European Journal of Clinical Pharmacology, 65 1113-1120 (2009) [C1]
DOI 10.1007/s00228-009-0706-8
Citations Scopus - 12Web of Science - 10
2009 Ashton KA, Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, et al., 'Polymorphisms in TP53 and MDM2 combined are associated with high grade endometrial cancer', Gynecologic Oncology, 113 109-114 (2009) [C1]
DOI 10.1016/j.ygyno.2008.12.036
Citations Scopus - 32Web of Science - 32
Co-authors Rodney Scott, Ian Symonds, Mark Mcevoy
2009 Attia JR, Ioannidis JPA, Thakkinstian A, McEvoy MA, Scott R, Minelli C, et al., 'How to use an article about genetic association A: Background concepts', JAMA: Journal of the American Medical Association, 301 74-81 (2009) [C1]
DOI 10.1001/jama.2008.901
Citations Scopus - 71Web of Science - 71
Co-authors Rodney Scott, Mark Mcevoy
2009 Attia JR, Ioannidis JPA, Thakkinstian A, McEvoy MA, Scott R, Minelli C, et al., 'How to use an article about genetic association B: Are the results of the study valid?', JAMA: Journal of the American Medical Association, 301 191-197 (2009) [C1]
DOI 10.1001/jama.2008.946
Citations Scopus - 101Web of Science - 102
Co-authors Mark Mcevoy, Rodney Scott
2009 Attia JR, Ioannidis JPA, Thakkinstian A, McEvoy MA, Scott R, Minelli C, et al., 'How to use an article about genetic association C: What are the results and will they help me in caring for my patients?', JAMA: Journal of the American Medical Association, 301 304-308 (2009) [C1]
DOI 10.1001/jama.2008.993
Citations Scopus - 50Web of Science - 47
Co-authors Mark Mcevoy, Rodney Scott
2009 Hallinan R, Byrne A, Agho K, McMahon CG, Tynan P, Attia JR, 'Hypogonadism in men receiving methadone and buprenorphine maintenance treatment', International Journal of Andrology, 32 131-139 (2009) [C1]
DOI 10.1111/j.1365-2605.2007.00824.x
Citations Scopus - 43Web of Science - 29
2009 Thakkinstian A, Thompson JR, Minelli C, Attia JR, 'Choosing between per-genotype, per-allele, and trend approaches for initial detection of gene-disease association', Journal of Applied Statistics, 36 633-646 (2009) [C1]
DOI 10.1080/02664760802484990
Citations Scopus - 16Web of Science - 13
2009 Anothaisintawee T, Rattanasiri S, Ingsathit A, Attia JR, Thakkinstian A, 'Prevalence of chronic kidney disease: A systematic review and meta-analysis', Clinical Nephrology, 71 244-254 (2009) [C1]
Citations Scopus - 16Web of Science - 15
2009 Lowe J, Mensch M, McElduff P, Fitzgerald M, Attia JR, 'Does an advanced insulin education programme improve outcomes and health service use for people with Type 2 diabetes? A 5-year follow-up of the Newcastle Empowerment course', Diabetic Medicine, 26 1277-1281 (2009) [C1]
DOI 10.1111/j.1464-5491.2009.02858.x
Citations Scopus - 2Web of Science - 1
Co-authors Patrick Mcelduff
2009 Narasimhan S, McKay K, Attia JR, 'Staff perspectives of a cardiac short stay unit', Australian Journal of Advanced Nursing, 26 23-28 (2009) [C1]
Citations Scopus - 1Web of Science - 1
Co-authors Seshasayee Narasimhan
2009 Tran HA, Reeves GE, Gibson R, Attia JR, 'Development of thyroid diseases in the treatment of chronic hepatitis C with alpha-interferon may be a good prognosticator in achieving a sustained virological response: A meta-analysis', Journal of Gastroenterology and Hepatology, 24 1163-1168 (2009) [C1]
DOI 10.1111/j.1440-1746.2009.05874.x
Citations Scopus - 18Web of Science - 15
2009 MacDonald K, Lowe J, Barker DJ, Mensch M, Attia JR, 'Effect of popular takeaway foods on blood glucose levels in type 1 diabetes mellitus patients on intensive insulin therapy', International Journal of Clinical Practice, 63 189-194 (2009) [C1]
DOI 10.1111/j.1742-1241.2008.01970.x
Citations Scopus - 11Web of Science - 10
2009 Xu L, Dibley M, D'Este CA, Phillips M, Porteous JE, Attia JR, 'Food groups and risk of forearm fractures in postmenopausal women in Chengdu, China', Climacteric, 12 222-229 (2009) [C1]
DOI 10.1080/13697130802626958
Citations Scopus - 13Web of Science - 12
Co-authors Catherine Deste
2009 Ewald BD, Duke JM, Thakkinstian A, Attia JR, Smith WT, 'Physical activity of older Australians measured by pedometry', Australasian Journal on Ageing, 28 127-133 (2009) [C1]
DOI 10.1111/j.1741-6612.2009.00372.x
Citations Scopus - 15Web of Science - 12
Co-authors Ben Ewald, Wayne Smith
2008 Osmotherly PG, Attia JR, Thakkinstian A, 'Can clinical measures of upper quarter postural muscle performance predict neck pain in visual display terminal operators?', Journal of Back and Musculoskeletal Rehabilitation, 21 113-120 (2008) [C1]
Citations Scopus - 1Web of Science - 1
Co-authors Peter Osmotherly
2008 Ewald BD, Ewald D, Thakkinstian A, Attia JR, 'Meta-analysis of B type natriuretic peptide and N-terminal pro B natriuretic peptide in the diagnosis of clinical heart failure and population screening for left ventricular systolic dysfunction', Internal Medicine Journal, 38 101-113 (2008) [C1]
DOI 10.1111/j.1445-5994.2007.01454.x
Citations Scopus - 64Web of Science - 59
Co-authors Ben Ewald
2008 Ashton KA, Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, et al., 'The influence of the Cyclin D1 870 G\A polymorphism as an endometrial cancer risk factor', BMC Cancer, 8 1-6 (2008) [C1]
DOI 10.1186/1471-2407-8-272
Citations Scopus - 8Web of Science - 7
Co-authors Mark Mcevoy, Ian Symonds, Rodney Scott
2008 Davis SM, Donnan GA, Parsons MW, Levi CR, Butcher KS, Peeters A, et al., 'Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): A placebo-controlled randomised trial', The Lancet Neurology, 7 299-309 (2008) [C1]
DOI 10.1016/s1474-4422(08)70044-9
Citations Scopus - 666Web of Science - 608
Co-authors Christopher Levi, Mark Parsons
2008 Dudding TE, Heron J, Thakkinstian A, Nurk E, Golding J, Pembrey M, et al., 'Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: A genetic association study and meta-analysis', Journal of Thrombosis and Haemostasis, 6 1868-1875 (2008) [C1]
DOI 10.111/j.1538-7836.2008.03134.x
Citations Scopus - 39Web of Science - 7
Co-authors T Dudding, Rodney Scott
2008 Hallinan R, Byrne A, Agho K, McMahon C, Tynan P, Attia JR, 'Erectile dysfunction in men receiving methadone and buprenorphine maintenance treatment', Journal of Sexual Medicine, 5 684-692 (2008) [C1]
DOI 10.1111/j.1743-6109.2007.00702.x
Citations Scopus - 78Web of Science - 62
2008 Ryan RL, King BR, Anderson DG, Attia JR, Collins CE, Smart CE, 'Influence of and optimal insulin therapy for a low-glycemic index meal in children with type 1 diabetes receiving intensive insulin therapy', Diabetes Care, 31 1485-1490 (2008) [C1]
DOI 10.2337/dc08-0331
Citations Scopus - 22Web of Science - 18
Co-authors Bruce King, Clare Collins
2008 Thakkinstian A, Dmitrienko S, Gerbase-Delima M, McDaniel DO, Inigo P, Chow KM, et al., 'Association between cytokine gene polymorphisms and outcomes in renal transplantation: A meta-analysis of individual patient data', Nephrology Dialysis Transplantation, 23 3017-3023 (2008) [C1]
DOI 10.1093/ndt/gfn185
Citations Scopus - 34Web of Science - 35
Co-authors Mark Mcevoy
2008 Minelli C, Thompson JR, Abrams KR, Thakkinstian A, Attia JR, 'How should we use information about HWE in the meta-analyses of genetic association studies', International Journal of Epidemiology, 37 136-146 (2008) [C1]
DOI 10.1093/ije/dym234
Citations Scopus - 72Web of Science - 67
2008 White JH, Magin PJ, Attia JR, Pollack MR, Sturm J, Levi CR, 'Exploring poststroke mood changes in community-dwelling stroke survivors: A qualitative study', Archives of Physical Medicine and Rehabilitation, 89 1701-1707 (2008) [C1]
DOI 10.1016/j.apmr.2007.12.048
Citations Scopus - 16Web of Science - 13
Co-authors Christopher Levi, Parker Magin
2008 Quain DA, Parsons MW, Loudfoot AR, Spratt NJ, Evans MK, Russell ML, et al., 'Improving access to acute stroke therapies: A controlled trial of organised pre-hospital and emergency care', Medical Journal of Australia, 189 429-433 (2008) [C1]
Citations Scopus - 78Web of Science - 66
Co-authors Mark Parsons, Neil Spratt, Christopher Levi, Patrick Mcelduff
2008 Thompson JR, Minelli C, Abrams KR, Thakkinstian A, Attia JR, 'Combining information from related meta-analyses of genetic association studies', Journal of the Royal Statistical Society: Applied Statistics, 57 103-115 (2008) [C1]
DOI 10.1111/j.1467-9876.2007.00603.x
Citations Scopus - 3Web of Science - 3
2008 Maguire JM, Thakkinstian A, Sturm J, Levi CR, Lincz L, Parsons MW, et al., 'Polymorphisms in platelet glycoprotein 1b [alpha] and factor VII and risk of ischemic stroke', Stroke, 39 1710-1716 (2008) [C1]
DOI 10.1161/strokeaha.107.507228
Citations Scopus - 30Web of Science - 28
Co-authors Christopher Levi, Lisa Lincz, Mark Parsons
2008 Lowe J, Linjawi S, Mensch M, James K, Attia JR, 'Flexible eating and flexible insulin dosing in patients with diabetes: Results of an intensive self-management course', Diabetes Research and Clinical Practice, 80 439-443 (2008) [C1]
DOI 10.1016/j.diabres.2008.02.003
Citations Scopus - 46Web of Science - 40
2008 D'Este CA, Attia JR, Brown AM, Gibson RE, Gibberd RW, Tavener MA, et al., 'Cancer incidence and mortality in aircraft maintenance workers', American Journal of Industrial Medicine, 51 16-23 (2008) [C1]
DOI 10.1002/ajim.20540
Citations Scopus - 5Web of Science - 5
Co-authors Catherine Deste, Meredith Tavener, Robert Gibberd
2008 Shi Z, McEvoy MA, Luu J, Attia JR, 'Dietary fat and sleep duration in Chinese men and women', International Journal of Obesity, 32 1835-1840 (2008) [C1]
DOI 10.1038/ijo.2008.191
Citations Scopus - 41Web of Science - 36
Co-authors Mark Mcevoy
2008 Thakkinstian A, Tran HA, Reeves GE, Murch S, Attia JR, 'A clinical decision rule to aid ordering of serum and urine protein electrophoresis for case-finding of paraproteins in hospitalized inpatients', Journal of General Internal Medicine, 23 1688-1692 (2008) [C1]
DOI 10.1007/s11606-008-0712-z
Citations Scopus - 4Web of Science - 4
2008 Osmotherly PG, Attia JR, 'The interplay of static and dynamic postural factors in neck pain', Hong Kong Physiotherapy Journal, 26 9-17 (2008) [C1]
DOI 10.1016/S1013-7025(09)70003-X
Citations Scopus - 3
Co-authors Peter Osmotherly
2007 Tran HA, Attia JR, Jones TL, Batey RG, 'Pegylated interferon-alpha 2 beta in combination with ribavirin does not aggravate thyroid dysfunction in comparison to regular interferon-alpha 2 beta in a hepatitis C population: Meta-analysis', Journal of Gastroenterology and Hepatology, 22 472-476 (2007) [C1]
DOI 10.1111/j.1440-1746.2006.04771.x
Citations Scopus - 24Web of Science - 22
2007 Attia JR, Thakkinstian A, Wang Y, Lincz L, Parsons MW, Sturm J, et al., 'The PAI-1 4G/5G gene polymorphism and ischemic stroke: An association study and meta-analysis', Journal of Stroke and Cerebrovascular Diseases, 16 173-179 (2007) [C1]
DOI 10.1016/j.jstrokecerebrovasdis.2007.03.002
Citations Scopus - 33
Co-authors Christopher Levi, Lisa Lincz, Mark Parsons, Rodney Scott
2007 Bailey H, Henley N, Robertson L, Armstrong B, Attia JR, Milne E, 'Applying Persuasion Principles Did Not Increase Questionnaire Response: A Randomised Controlled Trial of a Fridge Magnet Gift', Australasian Epidemiologist, 14 6-10 (2007) [C1]
2007 'Poster Abstracts', Internal Medicine Journal, 37 A109-A120 (2007)
DOI 10.1111/j.1445-5994.2007.01511.x
2007 White JH, Alston MK, Marquez JL, Sweetapple AL, Pollack MR, Attia JR, et al., 'Community-Dwelling Stroke Survivors: Function Is Not the Whole Story With Quality of Life', Archives of Physical Medicine and Rehabilitation, 88 1140-1146 (2007) [C1]
DOI 10.1016/j.apmr.2007.06.003
Citations Scopus - 27Web of Science - 26
Co-authors Jodie Marquez, Christopher Levi
2007 Honoki K, Stojanovski E, McEvoy MA, Fujii H, Tsujiuchi T, Kido A, et al., 'Prognostic significance of p16(INK4a) alteration for Ewing sarcoma - A meta-analysis', Cancer, 110 1351-1360 (2007) [C1]
DOI 10.1002/cncr.22908
Citations Scopus - 22Web of Science - 21
Co-authors Elizabeth Stojanovski, Mark Mcevoy
2007 Duke JM, McEvoy MA, Sibbritt DW, Guest M, Smith WT, Attia JR, 'Vibrotactile threshold measurement for detecting peripheral neuropathy: Defining variability and a normal range for clinical and research use', Diabetologia, 50 2305-2312 (2007) [C1]
DOI 10.1007/s00125-007-0813-y
Citations Scopus - 19Web of Science - 17
Co-authors Wayne Smith, Mark Mcevoy
2007 Wark PA, Bucchieri F, Johnston SL, Gibson PG, Hamilton L, Mimica J, et al., 'IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations', Journal of Allergy and Clinical Immunology, 120 586-593 (2007) [C1]
DOI 10.1016/j.jaci.2007.04.046
Citations Scopus - 106Web of Science - 98
Co-authors Peter Wark, Joanna Latter, Peter Gibson
2006 Jm S, Ms S, Gj H, Attia JR, Thakkinstian A, Yi Q, et al., 'Association between phosphodiesterase 4D gene and ischaemic stroke', Journal of Neurology, Neurosurgery and Psychiatry Online, 77 1067-1069 (2006) [C1]
DOI 10.1136/jnnp.2006.092106
Citations Scopus - 57Web of Science - 55
2006 Schofield PW, Gibson RE, Tavener MA, Attia JR, D'Este CA, Guest M, et al., 'Neuropsychological health in F-111 aircraft maintenance workers', NeuroToxicology, 27 852-860 (2006) [C1]
DOI 10.1016/j.neuro.2006.02.002
Citations Scopus - 11Web of Science - 11
Co-authors Peter Schofield, Meredith Tavener, Catherine Deste
2006 Reeves GEM, Squance ML, Duggan AE, Murugasu RR, Wilson RJ, Wong RC, et al., 'Diagnostic accuracy of coeliac serological tests: a prospective study', EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 18 493-501 (2006)
DOI 10.1097/00042737-200605000-00006
Citations Scopus - 78Web of Science - 67
2006 Khoshdel A, Thakkinstian A, Carney SL, Attia JR, 'Estimation of an age-specific reference interval for pulse wave velocity: a meta-analysis', Journal of Hypertension, 24 1231-1237 (2006) [C1]
DOI 10.1097/01.hjh.0000234098.85497.31
Citations Scopus - 44Web of Science - 40
2006 Attia JR, Page JH, 'A graphic framework for teaching critical appraisal of randomised controlled trials', Equine Veterinary Journal, 38 7-9 (2006) [C1]
DOI 10.2746/042516406775374199
Citations Scopus - 1Web of Science - 1
2006 Thakkinstian A, Han PY, McEvoy MA, Smith WT, Hoh J, Magnusson K, et al., 'Systematic review and meta-analysis of the association between complementary factor HY402H polymorphisms and age-related macular degeneration', Human Molecular Genetics, 15 2784-2790 (2006) [C1]
DOI 10.1093/hmg/ddl220
Citations Scopus - 163Web of Science - 149
Co-authors Wayne Smith, Mark Mcevoy
2006 Hallinan R, Ray J, Byrne A, Agho KE, Attia JR, 'Therapeutic thresholds in methadone maintenance treatment: A receiver operating characteristic analysis', Drug and Alcohol Dependence, 81 129-136 (2006) [C1]
DOI 10.1016/j.drugalcdep.2005.06.005
Citations Scopus - 16Web of Science - 18
2006 Khoshdel A, Attia JR, Carney SL, 'Basic concepts in meta-analysis: a primer for clinicians', International Journal of Clinical Practice, 60 1287-1294 (2006) [C1]
DOI 10.1111/j.1742-1241.2006.01078.x
Citations Scopus - 25Web of Science - 22
2006 Zhang X, Attia JR, D'Este CA, Ma X-Y, 'The relationship between higher blood pressure and ischaemic, haemorrhagic stroke among Chinese and Caucasians: meta-analysis', European Journal of Cardiovascular Prevention and Rehabilitation, 13 429-437 (2006) [C1]
DOI 10.1097/01.hjr.0000214607.99113.b8
Citations Scopus - 23Web of Science - 18
Co-authors Catherine Deste
2006 Osmotherly PG, Attia JR, 'The healthy worker survivor effect in a study of neck muscle performance measures in call-centre operators', Work, 26 399-406 (2006) [C1]
Citations Scopus - 5
Co-authors Peter Osmotherly
2006 Xu L, Phillips M, D'Este CA, Dibley MJ, Porteous JE, Attia JR, 'Diet, activity, and other lifestyle risk factors for forearm fracture in postmenopausal women in China: a case-control study', Menopause - The Journal of the North American Menopause Society, 13 102-110 (2006) [C1]
DOI 10.1097/01.gme.0000191206.20738.da
Citations Scopus - 4Web of Science - 5
Co-authors Catherine Deste
2006 Attia JR, D'Este CA, Schofield PW, Brown AM, Gibson RE, Tavener MA, et al., 'Mental health in F-111 maintenance workers: the study of Health Outcomes in Aircraft Maintenance Personnel (SHOAMP) general health and medical study', Journal of Occupational and Environmental Medicine, 48 682-691 (2006) [C1]
DOI 10.1097/01.jom.0000205985.00559.84
Citations Scopus - 12Web of Science - 10
Co-authors Meredith Tavener, Peter Schofield, Catherine Deste
2006 Thakkinstian A, Bowe SJ, McEvoy MA, Smith WT, Attia JR, 'Association between apolipoprotein E polymorphisms and age-related macular degeneration: A HuGE review and meta-analysis', American Journal of Epidemiology, 164 813-822 (2006) [C1]
DOI 10.1093/aje/kwj279
Citations Scopus - 64Web of Science - 53
Co-authors Mark Mcevoy, Wayne Smith
2005 Thakkinstian A, McEvoy MA, Minelli C, Gibson PG, Hancox B, Duffy D, et al., 'Systematic review and meta-analysis of the association between beta(2)-adrenoceptor polymorphisms and asthma: A HuGE review', American Journal of Epidemiology, 162 201-211 (2005) [C1]
DOI 10.1093/aje/kwi184
Citations Scopus - 272Web of Science - 266
Co-authors Peter Gibson, Mark Mcevoy
2005 Minelli C, Thompson JR, Abrams KR, Thakkinstian A, Attia JR, 'The choice of a genetic model in the meta-analysis of molecular association studies', International Journal of Epidemiology, 34 1319-1328 (2005) [C1]
DOI 10.1093/ije/dyi169
Citations Scopus - 115Web of Science - 110
2005 Attia J, Schofield P, 'What now for Alzheimer's disease? An epidemiological evaluation of the AD2000 trial', Australian Prescriber, 28 134-135 (2005)
Citations Scopus - 1
Co-authors Peter Schofield
2005 Lindqvist PG, Merlo J, Dudding T, Attia J, 'Rebuttal: Meta-analysis of the relationship of factor V Leiden and intrauterine growth restriction-based on solid evidence? (multiple letters) [6]', Thrombosis and Haemostasis, 94 230-232 (2005)
Co-authors T Dudding
2005 Zhang X, Attia JR, D'Este CA, Yu XH, Wu XG, 'A risk score predicted coronary heart disease and stroke in a Chinese cohort', Journal of Clinical Epidemiology, 58 951-958 (2005) [C1]
DOI 10.1016/j.jclinepi.2005.01.013
Citations Scopus - 36Web of Science - 30
Co-authors Catherine Deste
2005 Settakorn J, Rangdaeng S, Arpornchayanon O, Lekawanvijit S, Bhoopat L, Attia JR, 'Why were limbs amputated? An evaluation of 216 surgical specimens from Chiang Mai University', Archives of Orthopaedic and Trauma Surgery, 125 701-705 (2005) [C1]
DOI 10.1007/s00402-005-0060-y
Citations Scopus - 12Web of Science - 6
2005 Thakkinstian A, McElduff P, D'Este CA, Duffy D, Attia JR, 'A method for meta-analysis of molecular association studies', Statistics in Medicine, 24 1291-1306 (2005) [C1]
DOI 10.1002/sim.2010
Citations Scopus - 395Web of Science - 392
Co-authors Catherine Deste, Patrick Mcelduff
2005 Chiarelli PE, Bower W, Wilson AJ, Attia JR, Sibbritt DW, 'Estimating the prevalence of urinary and faecal incontinence in Australia: systematic review', Australasian Journal on Ageing, 24 19-27 (2005) [C1]
DOI 10.1111/j.1741-6612.2005.00063.x
Citations Scopus - 19Web of Science - 20
Co-authors Amanda Wilson, Pauline Chiarelli
2004 Xu L, McElduff P, D'Este CA, Attia JR, 'Does dietary calcium have a protective effect on bone fractures in women? A meta-analysis of observational studies', The British Journal of Nutrition, 91 625-634 (2004) [C1]
DOI 10.1079/BJN20031085
Citations Scopus - 24Web of Science - 21
Co-authors Catherine Deste, Patrick Mcelduff
2004 Attia JR, Nair BR, Mears SR, Hitchcock K, 'Patient-oxygen dissociation curves: surveying the spectrum of oxygen-delivery methods', MJA, 181 677-678 (2004) [C1]
Citations Scopus - 4Web of Science - 3
2004 Attia JR, Nair BR, Sibbritt DW, Ewald BD, Paget NS, Wellard RF, et al., 'Generating pre-test probabilities: a neglected area in clinical decision making', Medical Journal of Australia, 180 449-454 (2004) [C1]
Citations Scopus - 31Web of Science - 23
Co-authors Ben Ewald
2004 Zhang X, Attia JR, D'Este CA, Yu X, 'Prevalence and Magnitude of Classical Risk Factors for Stroke in a Cohort of 5092 Chinese Steelworkers Over 13.5 Years of Follow-up', Stroke, 35 1052-1056 (2004) [C1]
DOI 10.1161/01.STR.0000125305.12859.ff
Citations Scopus - 37Web of Science - 32
Co-authors Catherine Deste
2004 Rodsutti J, Hensley M, Thakkinstian A, D'Este C, Attia J, 'A clinical decision rule to prioritize polysomnography in patients with suspected sleep apnea', SLEEP, 27 694-699 (2004) [C1]
Citations Scopus - 24Web of Science - 23
Co-authors Michael Hensley, Catherine Deste
2004 Kelly H, Attia JR, Andrews R, Heller RF, 'The number needed to vaccinate (NNV) and population extensions of the NNV: comparison of influenza and pneumococcal vaccine programmes for people aged 65 years and over', Vaccine, 22 2192-2198 (2004) [C1]
DOI 10.1016/j.vaccine.2003.11.052
Citations Scopus - 46Web of Science - 43
2004 Ewald BD, Attia JR, 'Which test to detect microalbuminuria in diabetic patients?', Australian Family Physician, 33 565-568 (2004) [C1]
Citations Scopus - 19
Co-authors Ben Ewald
2004 Attia JR, Dudding TE, Infante-Rivard C, 'Addendum to: The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: A meta-analysis', Thrombosis and Haemostasis, 92 434 (2004) [C3]
Citations Scopus - 2
Co-authors T Dudding
2004 Thakkinstian A, D'Este CA, Eisman J, Nguyen T, Attia JR, 'Meta-Analysis of Molecular Association Studies: Vitamin D Receptor Gene Polymorphisms and BMD as a Case Study', Journal of Bone & Mineral Research, 19 419 (2004) [C1]
DOI 10.1359/JBMR.0301265
Citations Scopus - 166Web of Science - 139
Co-authors Catherine Deste
2004 Thakkinstian A, D'Este CA, Attia JR, 'Haplotype analysis of VDR gene polymorphisms: a meta-analysis', Osteoporosis International: with other metabolic bone diseases, 15 729-734 (2004) [C1]
DOI 10.1007/s00198-004-1601-x
Citations Scopus - 53Web of Science - 44
Co-authors Catherine Deste
2004 Attia JR, D'Este CA, Levi CR, 'The progress trial three years later. HOPE trial may shed some light', BMJ, 329 1403-1404 (2004) [C1]
DOI 10.1136/bmj.329.7479.1403-d
Co-authors Christopher Levi, Catherine Deste
2004 Attia J, Eikelboom JW, Chunilal SD, Ginsberg JS, Mehra MR, 'Review: Clinical gestalt strategies and clinical prediction rules have similar discriminate pretest probabilities of pulmonary embolism', Evidence-Based Medicine, 9 155 (2004)
DOI 10.1136/ebm.9.5.155
2004 Dudding TE, Attia JR, 'The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: a meta-analysis', Journal of Thrombosis and Haemostasis, 91 700-711 (2004) [C2]
Citations Scopus - 105Web of Science - 82
Co-authors T Dudding
2004 Scott R, Crooks R, Rose L, Attia JR, Thakkinstian A, Thomas L, et al., 'Germline Missense Changes in the APC Gene and Their Relationship to Disease', Hereditary Cancer in Clinical Practice, 2 81-91 (2004) [C1]
DOI 10.1186/1897-4287-2-2-81
Co-authors Rodney Scott
2004 Xf Z, Attia JR, D'Este CA, Yu X, Wu X, 'Prevalence and magnitude of classical risk factors for coronary heart disease in a cohort of 4400 Chinese steelworkers over 13.5 years' follow-up', European Journal of Cardiovascular Prevention & Rehabilitation, 11 113-120 (2004) [C1]
DOI 10.1097/01.hjr.0000125480.31039.37
Citations Scopus - 16Web of Science - 15
Co-authors Catherine Deste
2004 Attia JR, 'Statistics with common sense', Australian Prescriber, 27 66-66 (2004)
2003 Page J, Attia JR, 'Using Bayes nomogram to help interpret odds ratios', EBM Online Evidence-based Medicine, 8 132-134 (2003) [C2]
Citations Scopus - 7
2003 Chiarelli PE, Bower W, Wilson AJ, Sibbritt DW, Attia JR, 'The prevalence of urinary incontinence in the community: a systematic review', Commonwealth Department of Health and Aged Care, (2003) [C3]
Co-authors Amanda Wilson, Pauline Chiarelli
2003 Chiarelli PE, Bower W, Wilson AJ, Sibbritt DW, Attia JR, 'The prevalence of faecal incontinence: a systematic review', Commonwealth Department of Health and Aged Care, (2003) [C3]
Co-authors Pauline Chiarelli, Amanda Wilson
2003 Page J, Attia J, 'Using Bayes' nomogram to help interpret odds ratios.', ACP journal club, 139 (2003)
Citations Scopus - 4
2003 Nair BR, Attia JR, Bowe SJ, Mears SR, Hitchcock K, 'Interns are from Venus, consultants are from Mars: differential perception among clinicians', Medical Journal of Australia, 179 659-661 (2003) [C1]
Citations Scopus - 1Web of Science - 1
2003 Wang Y, Levi CR, Attia JR, D'Este CA, Spratt N, Fisher JD, 'Seasonal Variation in Stroke in the Hunter Region, Australia: A 5-Year Hospital-Based Study, 1995-2000', Stroke: a journal of cerebral circulation, 34 1144-1150 (2003) [C1]
DOI 10.1161/01.STR.0000067703.71251.B6
Citations Scopus - 84Web of Science - 80
Co-authors Neil Spratt, Christopher Levi, Catherine Deste
2003 Chunilal S, Eikelboom JW, Attia JR, Miniati M, Panju A, Simel DL, Ginsberg JS, 'Does this Patient Have Pulmonary Embolism?', JAMA, 290 2849-2858 (2003) [C1]
DOI 10.1001/jama.290.21.2849
Citations Scopus - 124Web of Science - 98
2003 Edwards MJ, Agho KE, Attia JR, Diaz P, Hayes T, Illingworth A, Roddick LG, 'Case-Control Study of Cleft Lip or Palate After Maternal Use of Topical Corticosteroids During Pregnancy', American Journal of Medical Genetics, 120 459-463 (2003) [C1]
DOI 10.1002/ajmg.a.20130
Citations Scopus - 51Web of Science - 44
2003 Attia J, 'Moving beyond sensitivity and specificity: Using likelihood ratios to help interpret diagnostic tests', Australian Prescriber, 26 111-113 (2003)

Properties of diagnostic tests have traditionally been described using sensitivity, specificity, and positive and negative predictive values. These measures, however, reflect popu... [more]

Properties of diagnostic tests have traditionally been described using sensitivity, specificity, and positive and negative predictive values. These measures, however, reflect population characteristics and do not easily translate to individual patients. Likelihood ratios are a more practical way of making sense of diagnostic test results and have immediate clinical relevance. In general a useful test provides a high positive likelihood ratio and a small negative likelihood ratio.

Citations Scopus - 82
2003 Attia JR, Thakkinstian A, D'Este CA, 'Meta-analyses of molecular association studies: Methodologic lessons for genetic epidemiology', The Journal of Clinical Epidemiology, 297-303 (2003) [C1]
DOI 10.1016/S0895-4356(03)00011-8
Citations Scopus - 247Web of Science - 239
Co-authors Catherine Deste
2003 Attia J, Nair K, Price JM, Jacobs A, 'On abandoning ties and avoiding nose rings [7]', British Medical Journal, 327 345 (2003)
Citations Scopus - 2
2003 Wang Y, Levi CR, D'Este CA, Attia JR, Fisher JD, 'Variation of Stroke Attack Rates in Rural, Urban, and Coalfields Areas of the Hunter Region, Australia 1995-2000', Journal of Stroke & Cerebrovascular Diseases, 12 103-110 (2003) [C1]
DOI 10.1053/jscd.2003.12
Citations Scopus - 3
Co-authors Christopher Levi, Catherine Deste
2002 Nair BR, Attia JR, Mears S, Hitchcock K, 'Evidence-based physicians' dressing: a crossover trial', Medical Journal of Australia, 177(2) 681-682 (2002) [C1]
Citations Scopus - 19Web of Science - 17
2002 Attia JR, Page J, Heller R, Dobson A, 'Impact numbers in health policy decisions', Journal of Epidemiology & Community Health, 56 600-605 (2002) [C1]
Citations Scopus - 20Web of Science - 14
2002 Heller R, Dobson A, Attia JR, Page J, 'Impact numbers: measures of risk factor impact on the whole population from case-control and cohort studies', Journal of Epidemiology & Community Health, 56 606-610 (2002) [C1]
Citations Scopus - 31Web of Science - 23
2002 McElduff P, Attia JR, Ewald BD, Cockburn JD, Heller R, 'Estimating the contribution of individual risk factors to disease in a person with more than one risk factor', The Journal of Clinical Epidemiology, 55 588-592 (2002) [C1]
Citations Scopus - 18Web of Science - 14
Co-authors Patrick Mcelduff, Ben Ewald
2001 Attia JR, Ray J, Cook D, Douketis J, Ginsberg J, Geerts W, 'Deep vein thrombosis and its prevention in critically ill adults', Archives of Internal medicine, 161 1268-1279 (2001) [C1]
Citations Scopus - 224Web of Science - 184
2001 Edmond K, Attia JR, D'Este CA, Condon J, 'Drowning and near-drowning in Northern Territory children', Medical Journal of Australia, 175 605-608 (2001) [C1]
Citations Scopus - 11Web of Science - 10
Co-authors Catherine Deste
2001 Attia J, Page J, 'A graphic framework for teaching critical appraisal of randomized controlled trials.', ACP journal club, 134 (2001)

Students of evidence-based medicine often try unsuccessfully to commit to memory a particular critical appraisal framework (often lengthy), or they have to depend on pocket cards ... [more]

Students of evidence-based medicine often try unsuccessfully to commit to memory a particular critical appraisal framework (often lengthy), or they have to depend on pocket cards and are lost without them. We have described a pedagogic aid: a flow diagram of an RCT, which has been developed over years of teaching residents. This diagram focuses on the steps in an RCT, and by drawing arrows, it highlights the biases possible at each step. This diagram serves as a framework on which the list of critical appraisal questions can be hung and is easy to remember.

2001 Attia J, Page J, 'A graphic framework for teaching critical appraisal of randomised controlled trials', Evidence-Based Medicine, 6 68-69 (2001)

Students of evidence-based medicine often try unsuccessfully to commit to memory a particular critical appraisal framework (often lengthy), or they have to depend on pocket cards ... [more]

Students of evidence-based medicine often try unsuccessfully to commit to memory a particular critical appraisal framework (often lengthy), or they have to depend on pocket cards and are lost without them. We have described a pedagogic aid: a flow diagram of an RCT, which has been developed over years of teaching residents. This diagram focuses on the steps in an RCT, and by drawing arrows, it highlights the biases possible at each step. This diagram serves as a framework on which the list of critical appraisal questions can be hung and is easy to remember.

DOI 10.1136/ebm.6.3.68
Citations Scopus - 2
2001 Attia JR, Page J, 'Editorial: A graphic framework for teaching critical appraisal of randomzied controlled trials', Internal Medicine Journal, 134 A11-A12 (2001) [C2]
2000 Cook D, Attia JR, Weaver B, McDonald E, Meade M, Crowther M, 'Venous Thromboembolic Disease: An Observational Study in Medical-Surgical Intensive Care Unit Patients', Journal of Critical Care, 15 127-132 (2000) [C1]
Citations Scopus - 75Web of Science - 61
2000 Attia J, Margetts P, Guyatt G, 'Review: Sensitive thyrotropin testing in unselected inpatients has low diagnostic accuracy. Commentary', Evidence-Based Medicine, 5 29 (2000)
DOI 10.1136/ebm.5.1.29
Citations Scopus - 1
2000 Attia J, Hatala R, Cook DJ, Wong JG, 'Review: The physical examination can exclude the diagnosis of meningitis in low-risk adults. Commentary', Evidence-Based Medicine, 5 28 (2000)
DOI 10.1136/ebm.5.1.28
Citations Scopus - 1
1999 Attia J, Margetts P, Guyatt G, 'Diagnosis of thyroid disease in hospitalized patients - A systematic review', ARCHIVES OF INTERNAL MEDICINE, 159 658-665 (1999)
DOI 10.1001/archinte.159.7.658
Citations Scopus - 63Web of Science - 44
1999 Attia J, Hatala R, Cook DJ, Wong JG, 'Does this adult patient have acute meningitis?', JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 282 175-181 (1999)
DOI 10.1001/jama.282.2.175
Citations Scopus - 158Web of Science - 114
1999 Douketis JD, Feightner JW, Attia J, Feldman WF, 'Periodic health examination, 1999 update: 1. Detection, prevention and treatment of obesity', CANADIAN MEDICAL ASSOCIATION JOURNAL, 160 513-525 (1999)
Citations Scopus - 140Web of Science - 107
1998 Attia J, Cook DJ, 'Prognosis in anoxic and traumatic coma', CRITICAL CARE CLINICS, 14 497-+ (1998)
DOI 10.1016/S0749-0704(05)70013-0
Citations Scopus - 47Web of Science - 33
1998 Attia JR, Cook D, 'Indicators of poor neurologic prognosis in patients comatose due to intracranial bleeds and trauma: a systematic review and critical appraisal of the evidence.', Clinical Intensive Care, 9 129-133 (1998)
Citations Scopus - 1
1996 Attia JR, Cook D, 'Indicators of poor neurological prognosis in patients with anoxic coma: a systematic review and critical appraisal of the evidence.', Clinical Intensive Care, 7 244-247 (1996)
Citations Scopus - 1
1995 Attia J, Gupta S, Dunn RJ, 'Expression and secretion of a soluble form of myelin-associated glycoprotein (MAG).', Methods in molecular biology (Clifton, N.J.), 39 363-384 (1995)
Citations Scopus - 1
1993 ATTIA J, HICKS L, OIKAWA K, KAY CM, DUNN RJ, 'STRUCTURAL-PROPERTIES OF THE MYELIN-ASSOCIATED GLYCOPROTEIN ECTODOMAIN', JOURNAL OF NEUROCHEMISTRY, 61 718-726 (1993)
Citations Scopus - 10Web of Science - 9
1989 ATTIA J, TROPAK M, JOHNSON PW, NEWERLYABRANOW W, PAWSON T, RODER JC, DUNN RJ, 'MODULATED ADHESION - A PROPOSAL FOR THE ROLE OF MYELIN-ASSOCIATED GLYCOPROTEIN IN MYELIN WRAPPING', CLINICAL CHEMISTRY, 35 717-720 (1989)
Citations Scopus - 10Web of Science - 11
1989 JOHNSON PW, ATTIA J, RICHARDSON CD, RODER JC, DUNN RJ, 'SYNTHESIS OF SOLUBLE MYELIN-ASSOCIATED GLYCOPROTEIN IN INSECT AND MAMMALIAN-CELLS', GENE, 77 287-296 (1989)
DOI 10.1016/0378-1119(89)90076-0
Citations Scopus - 7Web of Science - 12
1987 Fitt PS, Sharma N, Attia J, Korecky B, 'Studies of adenosine incorporation in Langendorff rat heart and rat heart mitochondria', Molecular and Cellular Biochemistry: an international journal for chemical biology in health and disease, 78 37-46 (1987)
Cheng THT, Thompson D, Painter J, O'Mara T, Gorman M, Martin L, et al., 'Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.', Sci Rep, 5 17369 [C1]
DOI 10.1038/srep17369
Citations Scopus - 3Web of Science - 2
Co-authors Rodney Scott, Mark Mcevoy, Liz Holliday
Okbay A, Beauchamp JP, Fontana MA, Lee JJ, Pers TH, Rietveld CA, et al., 'Genome-wide association study identifies 74 loci associated with educational attainment.', Nature, 533 539-542 [C1]
DOI 10.1038/nature17671
Citations Scopus - 65Web of Science - 68
Co-authors Christopher Oldmeadow, Liz Holliday, Rodney Scott
Gorski M, van der Most PJ, Teumer A, Chu AY, Li M, Mijatovic V, et al., '1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.', Sci Rep, 7 45040
DOI 10.1038/srep45040
Citations Web of Science - 2
Co-authors Rodney Scott, Mark Mcevoy, Liz Holliday
Show 496 more journal articles

Review (1 outputs)

Year Citation Altmetrics Link
2004 Attia JR, 'Statistics with common sense', Australian Prescriber (2004) [D2]

Conference (95 outputs)

Year Citation Altmetrics Link
2017 Potter MDE, Brogan G, Walker MM, Mcevoy M, Hancock S, Holliday E, et al., 'Susceptibility for celiac disease based on tissue transglutaminase seroprevalence and HLA genotype in a community study', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2017)
Co-authors Nicholas Talley, Mark Mcevoy, Marjorie Walker
2017 Visser M, Goodin P, Lillicrap T, Krishnamurthy V, Attia J, Pagram H, et al., 'Modulation of resting-state networks in stroke survivors with severe post-stroke fatigue', INTERNATIONAL JOURNAL OF STROKE (2017)
Co-authors Andrew Bivard, Michael Nilsson
2016 Kepreotes E, Whitehead B, Lee M, Collison A, Goddard B, Cheese L, et al., 'HIGH-FLOW OXYGEN COMPARED TO STANDARD NASAL CANNULA OXYGEN DOES NOT REDUCE THE MEDIAN TIME ON OXYGEN FOR INFANTS WITH MODERATE BRONCHIOLITIS', RESPIROLOGY (2016)
Co-authors Joerg Mattes, Adam Collison, Christopher Oldmeadow
2016 Biswas M, Daneshi N, Dias T, Rasiah R, Mate K, Holliday E, et al., 'Prevalence of drug and gene interactions for cardiovascular drugs in older Australians' (2016)
Co-authors David Newby, Liz Holliday, Liz Milward, Rohan Rasiah, Karen Kerr, Karen Mate
2016 Faulkner S, Jobling P, Rowe C, Oldmeadow C, Roselli S, Thorne R, et al., 'CLINICOPATHOLOGICAL SIGNIFICANCE OF PRONGF RECEPTORS IN THYROID CANCER', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2016)
Co-authors Hubert Hondermarck, Rick Thorne, Phillip Jobling, Christopher Oldmeadow, Marjorie Walker
2016 Chiong F, Holliday E, Hancock S, Oakley S, Atria J, 'ASSOCIATION BETWEEN ELEVATED RHEUMATOID FACTOR AND CARDIOVASCULAR DISEASE HOSPITALISATION IN A NON-CLINICAL POPULATION', INTERNAL MEDICINE JOURNAL (2016)
Co-authors Liz Holliday, Stephen Oakley
2016 Kelly PJ, Baker AL, Deane FP, Callister R, Collins C, Oldmeadow C, et al., 'ADDRESSING SMOKING, DIET AND PHYSICAL ACTIVITY WITHIN RESIDENTIAL SUBSTANCE ABUSE TREATMENT: RESULTS FROM A STEPPED WEDGE RANDOMISED CONTROLLED TRIAL', INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE (2016)
Co-authors Robin Callister, Amanda Baker, Clare Collins, Christopher Oldmeadow
2016 McCrabb S, Bonevskil B, Attia J, Baker A, Lott N, Balogh Z, et al., 'INTERNET USE AMONG ORTHOPAEDIC TRAUMA PATIENTS', INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE (2016)
Co-authors Zsolt Balogh, Amanda Baker, Luke Wolfenden
2016 Hodder RK, Freund M, Bowman J, Wolfenden L, Campbell E, Dray J, et al., 'EFFECTIVENESS OF A SCHOOL-BASED PROTECTIVE FACTOR INTERVENTION IN REDUCING ADOLESCENT TOBACCO, ALCOHOL AND ILLICIT SUBSTANCE USE', INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE (2016)
Co-authors Christopher Oldmeadow, Luke Wolfenden, Julia Dray Uon, John Wiggers, Rebecca Hodder, Jenny Bowman
2016 Hodder RK, Freund M, Bowman J, Campbell E, Wolfenden L, Dray J, et al., 'EFFECTIVENESS OF A UNIVERSAL SCHOOL-BASED INTERVENTION IN REDUCING ADOLESCENT TOBACCO, ALCOHOL AND ILLICIT SUBSTANCE USE WITHIN STUDENT SUBGROUPS: EXPLORATORY ASSESSMENT', INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE (2016)
Co-authors Christopher Oldmeadow, Rebecca Hodder, John Wiggers, Julia Dray Uon, Luke Wolfenden, Jenny Bowman
2016 McCrabb S, Bonevski B, Attia J, Baker A, Lott N, Balogh Z, et al., 'ANXIETY, DEPRESSION AND SUBSTANCE ABUSE AMONG ORTHOPAEDIC TRAUMA PATIENTS', INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE (2016)
Co-authors Amanda Baker, Billie Bonevski, Zsolt Balogh, Luke Wolfenden
2016 Paul CL, Ryan A, Attia JR, D'Este CA, Kerr E, Jayakody A, et al., 'THROMBOLYSIS IMPLEMENTATION IN STROKE (TIPS): VARIATION IN 'READINESS TO CHANGE' AND ENGAGEMENT WITH TRANSLATION STRATEGIES', INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE (2016)
Co-authors Catherine Deste, Chris Paul, Rob Sanson-Fisher, Frans Henskens, Christopher Levi
2016 Paul CL, Attia JR, D'Este CA, Ryan A, Kerr E, Henskens F, Levi CR, 'THROMBOLYSIS IMPLEMENTATION IN STROKE (TIPS): OUTCOMES OF A CLUSTER RANDOMISED TRIAL OF MULTIDISCIPLINARY COLLABORATIVE QUALITY IMPROVEMENT', INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE (2016)
Co-authors Frans Henskens, Catherine Deste, Christopher Levi, Chris Paul
2016 Angkananard T, Anothaisintawee T, Eursiriwan S, Mcevoy M, Attia J, Thakkinstian A, 'The prognostic effect of serum magnesium concentration in patients with heart failure', EUROPEAN JOURNAL OF HEART FAILURE (2016)
Co-authors Mark Mcevoy
2016 Maguire JM, Holliday E, Levi C, Attia J, Koblar S, Sturm J, et al., 'Helping stroke physicians choose who to thrombolyse -Targeting Optimal Thrombolysis Outcomes" -Preliminary data.', Neurology genetics (2016)
Co-authors Liz Holliday, Christopher Levi, Lisa Lincz
2015 Daneshi N, Graham M, Holliday E, Schneider J, Kerr KP, Rasiah R, et al., 'Clinically actionable pharmacogenomic variants in community-dwelling older Australians.', ASMR XXIII NSW Scientific Meeting: Programme and Abstracts (2015) [E3]
Co-authors Rodney Scott, Liz Milward, Rohan Rasiah, Liz Holliday, Karen Kerr, Jennifer Schneider
2015 Harris ML, Oldmeadow C, Hure A, Loxton D, Luu J, Attia J, 'Increased risk of type 2 diabetes in women: does perceived stress hold the key?' (2015) [O1]
Co-authors Alexis Hure, Melissa Harris
2015 Biswas M, Daneshi N, Rasiah R, Mate K, Holliday E, Attia J, et al., 'Prevalence of cytochrome P450 (CYP) substrate-inhibitor interactions in patients on clopidogrel and frequency of CYP2C19*2 gene variants', Australasian Pharmaceutical Science Association (APSA)- Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Joint Scientific Meeting. Book of Poster Abstracts (2015) [E3]
Co-authors Rohan Rasiah, Liz Milward, Karen Mate, Liz Holliday, Karen Kerr
2015 Bolton KA, Holliday EG, McEvoy M, Attia J, Proietto A, Otton G, et al., 'A novel short tandem repeat in the upstream regulatory region of the estrogen-induced gene EIG121 is potentially involved in cancer risk' (2015)
Co-authors Nikola Bowden, Liz Holliday, Rodney Scott
2015 Sarwar G, Attia J, Bisquera A, 'NEUTRAL EFFECT OF INHALED CORTICOSTEROIDS ON BONE MINERAL DENSITY', RESPIROLOGY (2015) [E3]
2015 Paul CL, Levi C, Ryan A, Kerr E, Henskens F, Attia J, et al., 'Variation in site 'readiness' and engagement in an implementation trial', 4th Annual NHMRC Symposium on Research Translation jointly with CIPHER (2015) [E3]
Co-authors Catherine Deste, Rob Sanson-Fisher, Frans Henskens, Christopher Levi, Chris Paul
2015 Bhaskar S, Bivard A, Parsons M, Nilsson M, Attia J, Stanwell P, Levi C, 'Delay of late-venous phase cortical vein filling in acute ischemic stroke patients' (2015) [E3]
Co-authors Andrew Bivard, Mark Parsons, Michael Nilsson, Christopher Levi, Peter Stanwell
2015 Pundavela J, Roselli S, Demont Y, Faulkner S, Attia J, Keene S, et al., 'The neuronal protein sortilin is expressed in aggressive breast cancers and participates in tumor cell growth and invasion', CANCER RESEARCH (2015) [E3]
DOI 10.1158/1538-7445.SABCS14-P6-01-11
Co-authors Hubert Hondermarck, Marjorie Walker
2015 Faulkner S, Roselli S, Demont Y, Choquet G, Leissner P, Oldmeadow C, et al., 'ProNGF AS A NEW BIOMARKER IN THYROID CANCER', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2015) [E3]
Co-authors Hubert Hondermarck, Marjorie Walker, Christopher Oldmeadow
2015 Makaroff AP, Attia J, Levi C, 'Seasonal variation in cervical arterial dissection in the Hunter New England region, New South Wales: a retrospective cohort study', Connect Physiotherapy Conference 2015: Conference Abstract E-book (2015) [E3]
Co-authors Christopher Oldmeadow, Christopher Levi, Lucy Thomas
2014 Denham JW, Joseph DJ, Lamb DS, Spry N, Duchesne GM, Matthews J, et al., 'Main oncologic endpoints of the TROG 03.04 (RADAR) Trial for men with locally advanced prostate cancer', JOURNAL OF CLINICAL ONCOLOGY (2014)
Citations Web of Science - 4
Co-authors Allison Steigler, Jim Denham
2014 Mather KA, Thalamuthu A, Oldmeadow C, Song F, Armstrong NJ, Poljak A, et al., 'Genome-wide significant results identified for plasma apolipoprotein h levels', Alzheimer's & Dementia (2014) [E3]
DOI 10.1016/j.jalz.2014.05.1526
Co-authors Rodney Scott, Christopher Oldmeadow, Peter Schofield, Liz Holliday, Mark Mcevoy
2014 Chouraki VA, Jakobsdottir J, Mather K, Adams H, Mollon J, Oldmeadow C, et al., 'A genome-wide meta-analysis of plasma clusterin levels in the charge consortium', Alzheimer's & Dementia (2014) [E3]
DOI 10.1016/j.jalz.2014.05.1159
Co-authors Liz Holliday, Christopher Oldmeadow, Rodney Scott
2014 Gunathilake R, Krishnamurthy V, Oldmedow C, Kerr E, Padmakumar C, Attia J, et al., 'Relationships between age, other predictive variables and the 90-day functional outcome after intravenous thrombolysis for acute ischemic stroke', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Co-authors Christopher Levi, Mark Parsons, Christopher Oldmeadow
2014 Kerr E, Sanson-Fisher RW, Paul CL, DEste C, Parsons M, Bladin C, et al., 'Thrombolysis ImPlementation in Stroke (TIPS): Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice: An overview of data collected during the baseline period', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Co-authors Christopher Levi, Frans Henskens, Mark Parsons, Chris Paul, Catherine Deste, Rob Sanson-Fisher
2014 Bidarian-Moniri A, Nilsson M, Attia J, Ejnell H, 'Prone positioning for treatment of obstructive sleep apnoea', JOURNAL OF SLEEP RESEARCH (2014) [E3]
Co-authors Michael Nilsson
2014 Bolton KA, Holliday EG, McEvoy M, Attia J, Proietto A, Otton G, et al., 'A highly polymorphic AG repeat in the upstream regulatory region of the estrogen gene EIG121 is a potential modifier of endometrial cancer risk.', Asia-Pacific Journal of Clinical Oncology (2014) [E3]
DOI 10.1111/ajco.12335
Co-authors Mark Mcevoy, Liz Holliday, Rodney Scott, Kelly Kiejda, Nikola Bowden
2014 Lai J, Hure A, McEvoy M, Byles J, Attia J, 'Diet Quality And Depressive Symptoms In Mid-age Australian Women: Results From Preliminary Analysis', International Society for Affective Disorders Oral Abstract Book (2014) [E3]
Co-authors Mark Mcevoy, Julie Byles, Alexis Hure
2013 Dickson A, White J, Magin P, Attia J, Sturm J, Carter G, et al., 'Exploring the experience of psychological morbidity and service access in community dwelling stroke survivors: A qualitative follow up study', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Citations Scopus - 2
Co-authors Gregory Carter, Parker Magin, Patrick Mcelduff
2013 Lai JS, Hiles S, Hure AJ, McEvoy M, Attia J, 'SYSTEMATIC REVIEW AND META-ANALYSIS OF DIETARY PATTERNS AND DEPRESSION: OBSERVATIONAL STUDIES', ANNALS OF NUTRITION AND METABOLISM (2013) [E3]
Co-authors Mark Mcevoy, Alexis Hure
2013 Collins N, Kodur S, Ahmad W, Barker D, Davies A, Attia J, 'Influence of Age on Outcome in Treatment of Pulmonary Arterial Hypertension', Heart, Lung and Circulation (2013) [E3]
DOI 10.1016/j.hlc.2013.05.190
2013 Thomas J, Parsons O, Traylor M, Li L, Bevan S, Sudlow C, et al., 'The impact of CCS and TOAST classification systems on genetic associations with ischaemic stroke', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Co-authors Liz Holliday, Christopher Levi
2013 Nyholt DR, Low S-K, Anderson CA, Painter JN, Uno S, Morris AP, et al., 'Meta-Analysis of GWA Studies Identifies New Endometriosis Risk Loci', REPRODUCTIVE SCIENCES (2013) [E3]
Co-authors Rodney Scott, Liz Holliday, Mark Mcevoy
2012 White JH, Magin PJ, Attia JR, Sturm J, Carter GL, McElduff P, Pollack MR, 'Trajectories of psychological distress: A longitudinal cohort study', Neurorehabilitation & Neural Repair: WCNR 2012 Oral Abstracts (2012) [E3]
Co-authors Gregory Carter, Parker Magin, Patrick Mcelduff
2012 White JH, Magin PJ, Attia JR, Sturm J, Carter GL, McElduff P, Pollack MR, 'Exploring post stroke changes in community dwelling stroke survivors: A mixed methods longitudinal cohort study', Neurorehabilitation & Neural Repair: WCNR 2012 Oral Abstracts (2012) [E3]
Co-authors Parker Magin, Gregory Carter, Patrick Mcelduff
2012 Islam MR, Khan I, Hassan SMN, McEvoy MA, D'Este CA, Attia JR, et al., 'Association between hypertension and chronic exposure in Bangladesh', Hypertension (2012) [E3]
Co-authors Mark Mcevoy, Milton Hasnat, Catherine Deste
2012 Minelli C, Gogele M, Thakkinstian A, Yurkiewich A, Pattaro C, Pramstaller PP, et al., 'Methods for meta-analyses of genome-wide association studies: Critical assessment of empirical evidence', Genetic Epidemiology (2012) [E3]
2012 Holliday S, Magin PJ, Dunbabin JS, Oldmeadow CJ, Henry J-M, Lintzeris N, et al., 'Motivating factors amongst NSW general practitioners regarding the prescription of opioid substitution therapy', Drug and Alcohol Review (2012) [E3]
Citations Web of Science - 1
Co-authors Parker Magin, A Dunlop, Christopher Oldmeadow
2012 Ewald BD, McElduff P, Attia JR, 'How many steps are enough? Dose response curves for objectively measured physical activity in an Australian community based sample', Journal of Science and Medicine in Sport (2012) [E3]
Co-authors Ben Ewald, Patrick Mcelduff
2012 Talseth-Palmer B, Holliday EG, Evans T-J, McEvoy MA, Attia JR, Grice DM, et al., 'A genome-wide CNV association study of Australian HNPCC/Lynch syndrome patients', Proceedings of the Australian Health & Medical Research Congress 2012 (2012) [E3]
Co-authors Liz Holliday, Rodney Scott, Bente Talseth-Palmer, Mark Mcevoy
2012 Ranasinghe WKB, Attia JR, Oldmeadow CJ, Lawrentschuk N, Robertson J, Ranasinghe T, et al., 'Bladder carcinoma in situ in Australia: A rising incidence for an under-reported malignancy', Asia-Pacific Journal of Clinical Oncology (2012) [E3]
Citations Scopus - 1
Co-authors Christopher Oldmeadow
2011 Courtney RJ, Paul CL, Sanson-Fisher RW, Macrae FA, Carey ML, Attia JR, McEvoy MA, 'Colorectal cancer screening in Australia: A community-level perspective', Asia-Pacific Journal of Clinical Oncology: COSA 38th Annual Scientific Meeting Poster Abstracts (2011) [E3]
DOI 10.5694/mja11.10661
Co-authors Mark Mcevoy, Mariko Carey, Rob Sanson-Fisher, Chris Paul
2011 Maguire JM, Holliday EG, Sturm J, Golledge J, Lewis M, Koblar S, et al., 'Australian stroke genetics collaborative: Genetic associations with ischaemic stroke functional outcome', International Journal of Stroke (2011) [E3]
Co-authors Christopher Levi, Liz Holliday, Lisa Lincz, Rodney Scott, Pablo Moscato, Mark Parsons
2011 White JH, Magin PJ, Attia JR, Sturm J, Carter GL, Fitzgerald MN, et al., 'Post-stroke depression and anxiety: A longitudinal cohort study', Journal of Neurology (2011) [E3]
Co-authors Parker Magin, Gregory Carter, Patrick Mcelduff
2011 Holliday S, Magin PJ, Dunlop AJ, Dunbabin JS, Henry J, Goode SM, et al., 'Opioid analgesics in chronic non-cancer pain: A quality use of medicines study', Drug and Alcohol Review (2011) [E3]
Co-authors Parker Magin, A Dunlop
2011 White JH, Magin PJ, Attia JR, Sturm J, Carter GL, Fitzgerald MN, et al., 'Post-stroke depression and anxiety: A longitudinal cohort study', Cerebrovascular Diseases (2011) [E3]
Co-authors Parker Magin, Gregory Carter, Patrick Mcelduff
2011 Russell ML, Evans MK, Royan AT, Magin PJ, Lasserson D, Attia JR, et al., 'Referral and triage of patients with TIAs to an acute access clinic: Risk-stratification performance in an Australian setting', International Journal of Stroke (2011) [E3]
Co-authors Christopher Levi, Patrick Mcelduff, Mark Parsons, Parker Magin, Neil Spratt
2011 White JH, Magin PJ, Attia JR, Sturm J, Carter GL, Pollack MR, 'Trajectories of psychological distress after stroke: A longitudinal, mixed methods cohort study', Stroke Society of Australasia Annual Scientific Meeting 2011 (SSA-ASM) (2011) [E3]
Co-authors Parker Magin, Gregory Carter
2011 Thomas L, Rivett DA, Levi CR, 'Risk factors and clinical presentation of craniocervical arterial dissection. A prospective study: Preliminary results', Physiotherapy: Abstracts, World Physical Therapy 2011 (2011) [E3]
Citations Scopus - 12Web of Science - 12
Co-authors Christopher Levi, Darren Rivett, Lucy Thomas
2011 Khan I, Hassan S, McEvoy MA, D'Este CA, Attia JR, Peel R, Hasnat MA, 'Association between type 2 diabetes and chronic arsenic exposure in Bangladesh', Epidemiology (2011) [E3]
Citations Web of Science - 2
Co-authors Catherine Deste, Roseanne Peel, Milton Hasnat, Mark Mcevoy
2011 Nickel J, Attia JR, Anothaisintawee T, Thakkinstian A, 'a-blockers, antibiotics and anti-inflammatories have a role in management of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)', Urology (2011) [E3]
2011 Allen J, Inder KJ, Kelly BJ, Attia JR, Lewin TJ, 'An interaction of social support and remoteness in the prediction of psychological distress', Journal of Epidemiology and Community Health (2011) [E3]
Co-authors Brian Kelly, Kerry Inder, Terry Lewin
2011 Ambikaipaker V, Mathew A, Attia JR, 'Serum tumour markers: a retrospective analysis. A guide in using serum tumour markers in predicting malignancy', Journal of Gastroenterology and Hepatology (2011) [E3]
2011 Holland R, Dunlop AJ, Hinman J, Ribbons K, Sadler CW, Gill AJ, et al., 'Buprenorphine-naloxone vs wait list control RCT: Health service utilisation and health economic outcomes', Drug and Alcohol Review (2011) [E3]
Co-authors Patrick Mcelduff, A Dunlop
2011 Gupta S, Lewis G, Rogers K, Attia J, 'QUANTITATIVE RENAL TRANSPLANT SCINTIGRAPHY: PATHOLOGICAL CORRELATION (ANZAPNM Award Entry)', INTERNAL MEDICINE JOURNAL (2011) [E3]
2010 Murphy VE, Namazy JA, Powell GH, Gibson PG, Chambers C, Attia JR, Schatz M, 'A meta-analysis of adverse perinatal outcomes in asthmatic women: Effect of asthma on placental and neonatal outcomes', American Journal of Respiratory and Critical Care Medicine (2010) [E3]
Co-authors Vanessa Murphy, Peter Gibson
2010 White JH, Magin PJ, Attia JR, Sturm J, Pollack MR, 'Exploring goal setting in stroke survivors: a prospective study', Cerebrovascular Diseases: European Stroke Conference (2010) [E3]
Co-authors Parker Magin
2010 White JH, Magin PJ, Attia JR, Sturm J, McElduff P, Pollack MR, 'Exploring post-stroke mood changes in community-dwelling stroke survivors: a prospective qualitative study', Cerebrovascular Diseases: European Stroke Conference (2010) [E3]
Co-authors Parker Magin, Patrick Mcelduff
2010 White JH, Magin PJ, Attia JR, Sturm J, McElduff P, Pollack MR, 'Exploring post-stroke mood changes in community-dwelling stroke survivors: a longitudinal cohort study', Cerebrovascular Diseases: European Stroke Conference (2010) [E3]
Co-authors Parker Magin, Patrick Mcelduff
2010 White J, Miller B, Magin PJ, Attia JR, Sturm J, 'Access and participation in the community: A prospective cohort qualitative study of driving post-stroke', Cerebrovascular Diseases: European Stroke Conference (2010) [E3]
Co-authors Parker Magin
2010 Miles S, Rogers K, Thomas P, Allen L, Soans B, Abel C, et al., 'Comparing the reliability of reporting of single photon emission computed tomography ventilation-perfusion scintigraphy (SPECT-VQ) and CT pulmonary angiogram (CTPA) in pulmonary embolism (PE) diagnosis', European Respiratory Society Annual Congress 2010. Abstracts (2010) [E3]
Co-authors Catherine Deste, Michael Hensley
2010 Maguire JM, Thakkinstian A, Levi CR, Lincz L, Bissett KE, Sturm J, et al., 'Genetic influences on ischemic stroke 90-day functional outcome: A novel association', Circulation (2010) [E3]
Co-authors Christopher Levi, Rodney Scott, Lisa Lincz
2010 Hiles SA, Attia JR, Baker AL, 'Changes in interleukin-6, C-reactive protein and interleukin-10 in people with depression following antidepressant treatment: A meta-analysis', Brain, Behavior, and Immunity (2010) [E3]
Co-authors Amanda Baker
2010 Hiles SA, Attia JR, Baker AL, 'Interleukin-6 in people with and without depression: Exploring moderators using meta-analytic techniques', Brain, Behavior, and Immunity (2010) [E3]
Co-authors Amanda Baker
2010 Dunlop A, Lintzeris N, Gill T, Sadler C, Ribbons K, Attia J, et al., 'EFFECTIVENESS AND COST EFFECTIVENESS OF UNSUPERVISED BUPRENORPHINE-NALOXONE VERSUS WAIT LIST CONTROL RCT', DRUG AND ALCOHOL REVIEW (2010) [E3]
Co-authors Patrick Mcelduff, A Dunlop
2010 Murphy VE, Namazy J, Powell GH, Gibson PG, Chambers C, Attia JR, Schatz M, 'A meta-analysis of adverse perinatal outcomes in asthmatic women: Effect of asthma on maternal and neonatal outcomes', Respirology (2010) [E3]
Co-authors Vanessa Murphy, Peter Gibson
2010 Murphy VE, Namazy J, Powell GH, Schatz M, Chambers C, Attia JR, Gibson PG, 'A meta-analysis of adverse perinatal outcomes in asthmatic women: Effect of asthma on size at birth and timing of birth', Respirology (2010) [E3]
Co-authors Vanessa Murphy, Peter Gibson
2010 Talseth-Palmer B, Holliday EG, Evans T-J, McPhillips M, McEvoy MA, Attia JR, Scott R, 'A modern approach to the search for modifying genetic loci infleuncing the high breast cancer incidence seen in an Australian HNPCC/Lynch Syndrome cohort', Proceedings of the Australian Health and Medical Research Congress 2010 (2010) [E3]
Co-authors Rodney Scott, Mark Mcevoy, Bente Talseth-Palmer, Liz Holliday
2010 Ranasinghe WKB, Wright T, Doyle TE, Attia JR, McElduff P, Persad R, 'Bariatric surgery: An added benefit for obese females with urinary incontinence?', BJU International (2010) [E3]
Co-authors Patrick Mcelduff
2009 Henry D, Lincz L, Attia JR, McElduff P, Bisset L, Peel R, et al., 'Polymorphisms in two regions of the cyclo-oxygenase-2 gene associated with variation in risk of coronary thrombosis with cyclo-oxygenase-2 inhibitors', Basic & Clinical Pharmacology & Toxicology (2009) [E3]
DOI 10.1111/j.1742-7843.2009.00436.x
Co-authors Lisa Lincz, Patrick Mcelduff, Roseanne Peel
2009 Osmotherly PG, Attia JR, McElduff P, 'The composite neck pain and disability questionnaire: Development and factor structure', Australian Journal of Physiotherapy: eSupplements (2009) [E3]
Co-authors Peter Osmotherly, Patrick Mcelduff
2009 Pickering PM, Osmotherly PG, Attia JR, McElduff P, 'An examination of outcome measures for pain and dysfunction in the cervical spine: A factor analysis', Australian Journal of Physiotherapy: eSupplements (2009) [E3]
Co-authors Patrick Mcelduff, Peter Osmotherly
2009 Maguire J, Thakkinstian A, Attia JR, Lincz L, Bisset L, Sturm J, et al., 'Impact of COX-2 RS5275, RS20417 and GPIIIA RS5918 polymorphisms on 90 day ischaemic stroke functional outcome: A novel association', Cerebrovascular Diseases (2009) [E3]
DOI 10.1159/000221772
Co-authors Rodney Scott, Christopher Levi, Lisa Lincz
2009 Jones LJ, Craven PD, Attia JR, Thakkinstian A, Wright IM, 'Administration of intravenous ibuprofen for significant PDA in preterm infants at greater than 24 h of life: Does it increase the risk of chronic lung disease (CLD)?', Journal of Paediatrics and Child Health (2009) [E3]
DOI 10.1111/j.1440-1754.2009.01475.x
Co-authors Ian Wright
2009 Henry D, Lincz L, Attia J, McElduff P, Bisset L, Peel R, et al., 'Polymorphisms in Two Regions of the Cyclo-Oxygenase-2 Gene Associated with Variation in Risk of Coronary Thrombosis with Cyclo-Oxygenase-2 Inhibitors', PHARMACOEPIDEMIOLOGY AND DRUG SAFETY (2009) [E3]
Co-authors Patrick Mcelduff, Lisa Lincz, Roseanne Peel
2008 Jones LJ, Craven PD, Attia JR, Wright I, 'Early targeted indomethacin: Where is the evidence?', Journal of Paediatrics and Child Health (2008) [E3]
DOI 10.1111/j.1440-1754.2008.01297.x
2008 Miles S, Rogers K, Thomas P, Soans B, Attia JR, Abel C, et al., 'Lung single photon emission computed tomography (SPECT): A useful tool for diagnosing pulmonary embolism', Respirology (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252_9.x
Co-authors Catherine Deste, Michael Hensley
2008 Boggess MM, Guest M, D'Este CA, Attia JR, 'Statistical methods to compare hearing thresholds to ISO-7029', Occupational & Environmental Medicine (2008) [E3]
Co-authors Catherine Deste
2008 Guest M, D'Este CA, Attia JR, Boggess MM, 'Impairment of hearing and balance in aircraft maintenance technicians', Occupational & Environmental Medicine (2008) [E3]
Co-authors Catherine Deste
2008 White JH, Magin PJ, Pollack MR, Attia JR, Sturm J, 'The long-term experience of altered mood in community dwelling stroke survivors: Methodology and preliminary findings of a longitudinal qualitative study', 2008 General Practice & Primary Health Care Research Conference: Program & Abstracts (2008) [E3]
Co-authors Parker Magin
2008 Wood LG, Attia JR, McElduff P, McEvoy MA, Flood V, Gibson PG, 'Dietary fat and an activated innate immune response are associated with reduced FEV1', Asia Pacific Journal of Clinical Nutrition (2008) [E3]
Co-authors Mark Mcevoy, Peter Gibson, Patrick Mcelduff, Lisa Wood
2008 Ashton KA, Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, et al., 'Combined tp53 r72p and mdm2 snp309 genotypes are associated with high grade endometrial cancer', ASMR XVII NSW Scientific Meeting: Programme and Abstracts (2008) [E3]
Co-authors Ian Symonds, Mark Mcevoy, Rodney Scott
2008 Oakley PW, Nair BR, Attia JR, 'Teaching hospital based formative assessment can predict Trainee performance in RACP written examination', ANZAME Conference 2008. Conference Program, Abstracts and Papers (2008) [E3]
2007 Maguire J, Sturm J, Attia JR, Whyte S, Bisset L, Lincz L, et al., 'A case-control genetic association study to examine platelet glycoprotein polymorphisms and ischaemic stroke risk', Internal Medicine Journal (2007) [E3]
Co-authors Lisa Lincz, Mark Parsons, Christopher Levi
2006 D'Este C, Attia J, Brown A, Schofield P, Tavener M, Gibson R, Horsley K, 'SHOAMP: The study of health outcomes in aircraft maintenance personnel.', NEUROTOXICOLOGY (2006)
Co-authors Meredith Tavener, Peter Schofield, Catherine Deste
2006 Ronan A, Thakkinstian A, Zakaria S, Settakorn J, Moscovis SM, Scott R, et al., 'The role of MTHFR polymorphisms and dietary folate in childhood cancer', Program of the 11th International Congress of Human Genetics (2006) [E3]
Co-authors Rodney Scott
2005 Guest M, Wigney DJ, Attia JR, D'Este CA, Brown A, Boggess M, 'Hearing Loss in Australian Military Aircraft Personnel', AIOH : 23rd Annual Conference of the Australian Institute of Occupational Hygienists & Annual General Meeting : conference proceedings : 3rd to 7th December 2005, Crowne Plaza, Terrigal, N.S.W (2005) [E2]
Co-authors Catherine Deste
2003 Osmotherly PG, Attia JR, 'Deep cervical flexor muscle performance and neck pain in call centre operators - a pilot study', Musculoskeletal Physiotherapy Australia 13th Biennial Conference (2003) [E3]
Co-authors Peter Osmotherly
2003 Wang Y, Levi CR, D'Este CA, Attia JR, Spratt N, Fisher J, 'Seasonal variation in stroke in the Hunter Region, Australia a five-year hospital-based study, 1995-2000', STROKE (2003)
Co-authors Catherine Deste, Christopher Levi, Neil Spratt
2003 Thakkinstian A, D'Este C, Eisman J, Nguyen T, Attia J, 'Meta-analysis of molecular association studies: The vitamin D receptor gene polymorphisms and bone mineral density as a case study.', JOURNAL OF BONE AND MINERAL RESEARCH (2003)
Co-authors Catherine Deste
Show 92 more conferences

Report (6 outputs)

Year Citation Altmetrics Link
2014 Gwynn JD, Blunden SV, Turner N, Flood V, Attia J, Smith W, et al., 'Many Rivers Diabetes Prevention Project: An Aboriginal community governed program of research and health promotion for children. Final Report August 2014', NSW MInistry of Health (2014) [R1]
Co-authors Catherine Deste, Wayne Smith, John Wiggers, Josephine Gwynn
2014 Gwynn JD, Blunden SV, Turner N, Flood V, Attia J, Smith W, et al., 'Many Rivers Diabetes Prevention Project: An Aboriginal community governed program of research and health promotion for children. Short Report.', NSW MInistry of Health, 27 (2014) [R1]
Co-authors John Wiggers, Catherine Deste, Wayne Smith, Josephine Gwynn
2004 D'Este C, Attia J, Byles JE, Brown A, Smith S, Tavener MA, Scientific Advisory Committee, 'Study of Health Outcomes in Aircraft Maintenance Personnel. Volume 4. Mortality and Cancer Incidence Study. Second Report.', Department of Defence and Department of Veterans' Affairs, 155 (2004)
Co-authors Julie Byles, Meredith Tavener, Catherine Deste
2004 D'Este C, Byles JE, Attia J, Brown A, Smith S, Tavener MA, Scientific Advisory Committee, 'Study of Health Outcomes in Aircraft Maintenance Personnel. Volume 2. Mortality and Cancer Incidence Study. Interim Report.', Department of Defence and Department of Veterans' Affairs, 105 (2004)
Co-authors Meredith Tavener, Julie Byles, Catherine Deste
2003 Byles J, D'Este C, Attia J, Brown A, Tavener MA, Smith S, Scientific Advisory Committee members, 'Study of Health Outcomes in Aircraft Maintenance Personnel. Volume 1. Literature Review. Final Report.', Department of Defence and Department of Veterans' Affairs, 148 (2003)
Co-authors Julie Byles, Catherine Deste
2003 Adams J, Milne L, Tavener MA, Byles JE, D'Este C, Attia J, et al., 'Study of Health Outcomes in Aircraft Maintenance Personnel. Volume 3. Qualitative Interviews. Final Report.', Department of Defence and Department of Veterans' Affairs, 88 (2003)
Co-authors Catherine Deste, Meredith Tavener
Show 3 more reports
Edit

Grants and Funding

Summary

Number of grants 88
Total funding $19,155,185

Click on a grant title below to expand the full details for that specific grant.


20178 grants / $1,776,841

Partnering with local government councils for scalable physical activity promotion in community parks$1,060,745

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Ronald Plotnikoff, Professor David Lubans, Professor Adrian Bauman, Associate Professor Mitch Duncan, Professor John Attia
Scheme Partnership Projects
Role Investigator
Funding Start 2017
Funding Finish 2021
GNo G1601350
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Does a targeted intervention improve medication safety after discharge and improve outcomes for people with dementia and their carers?$544,096

Funding body: Department of Health

Funding body Department of Health
Project Team Associate Professor Ashley Kable, Professor Dimity Pond, Professor John Attia, Conjoint Associate Professor Andrew Searles, Doctor Christopher Oldmeadow, Doctor Carolyn Hullick, Anne Fullerton
Scheme Dementia and Aged Care Services Research and Innovation Funding Round (DACS)
Role Investigator
Funding Start 2017
Funding Finish 2019
GNo G1601301
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

What type of leadership is required to improve the provision of evidenced-based best practice in acute stroke care?$50,000

Funding body: NSW Agency for Clinical Innovation (ACI)

Funding body NSW Agency for Clinical Innovation (ACI)
Project Team Associate Professor Christine Paul, Conjoint Professor Chris Levi, Professor Rebecca Mitchell, Doctor Andrew Bivard, Professor John Attia, Dr Martin Jude, Ms Annika Ryan
Scheme Research Project
Role Investigator
Funding Start 2017
Funding Finish 2018
GNo G1700672
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

PhD Scholarships Program 2017 - Panwar$40,000

Funding body: NSW Ministry of Health

Funding body NSW Ministry of Health
Project Team Dr Rakshit Panwar, Professor John Attia, Conjoint Professor Tony Quail, Professor Rinaldo Bellomo
Scheme PhD Scholarships Program
Role Lead
Funding Start 2017
Funding Finish 2018
GNo G1700884
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Preventable Mortality and the Immune System in Geriatric Hip Fracture$30,000

Funding body: NSW Ministry of Health

Funding body NSW Ministry of Health
Project Team Professor Zsolt Balogh, Professor John Attia, Mr Seth Tarrant
Scheme PhD Scholarships Program
Role Investigator
Funding Start 2017
Funding Finish 2018
GNo G1700883
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Using the Swedish National Population Medical Registry System to Explore Predictors of Post-Stroke Mood State and Cognitive Function$27,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Rohan Walker, Professor Michael Nilsson, Professor John Attia, Dr Leeanne Carey
Scheme Project Grant
Role Investigator
Funding Start 2017
Funding Finish 2017
GNo G1700296
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Quantification of genome-wide DNA methylation of 4-year-old offspring from a prospective cohort of pregnancy and childhood$20,000

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Alexis Hure, Miss Rachael Taylor, Professor John Attia
Scheme Research Grant
Role Investigator
Funding Start 2017
Funding Finish 2017
GNo G1700379
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Health technology evaluation$5,000

Funding body: CSIRO - Commonwealth Scientific and Industrial Research Organisation

Funding body CSIRO - Commonwealth Scientific and Industrial Research Organisation
Project Team Professor John Attia, Doctor Luke Wolfenden, Professor Vijay Varadharajan, Dr Craig Dalton, Conjoint Associate Professor Andrew Searles, Ms Jane Gray
Scheme ON Prime
Role Lead
Funding Start 2017
Funding Finish 2017
GNo G1701038
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20168 grants / $2,469,784

Telehealth and Advanced CT Imaging Combined Study (TACTICS)$992,098

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Chris Levi, Doctor Andrew Bivard, Professor John Attia, Professor Christopher Bladin, Professor Stephen Davis, Professor Geoff Donnan, Professor Craig Anderson, Dr Bruce Campbell, Professor Mark Parsons, Dr Rohan Grimley
Scheme Partnership Projects
Role Investigator
Funding Start 2016
Funding Finish 2021
GNo G1600728
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Efficacy and cost effectiveness of varying levels of technology-delivered personalised feedback on dietary patterns in motivating young Australian adults to improve diet quality and eating habits: The$595,601

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Clare Collins, Professor Helen Truby, Professor John Attia, Doctor Melinda Hutchesson, Associate Professor Tracy Burrows, Professor Robin Callister, Dr Leanne Hides, Professor Billie Bonevski, Conjoint Professor Christopher Doran
Scheme Targeted Call for Research - Preventing Obesity in 18-24 year olds
Role Investigator
Funding Start 2016
Funding Finish 2019
GNo G1500925
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The role of adjuvant zoledronic acid in locally advanced prostate cancer$384,133

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Jim Denham, Professor David Joseph, Professor G Duchesne, Professor John Attia
Scheme Project Grant
Role Investigator
Funding Start 2016
Funding Finish 2017
GNo G1500121
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

HMRI MRSP Infrastructure (12-16) Brain and Mental Health Program – Stroke and Brain Injury$325,297

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Neil Spratt, Professor Mark Parsons, Associate Professor Rohan Walker, Doctor Coralie English, Professor Michael Nilsson, Conjoint Professor Chris Levi, Doctor Andrew Bivard, Aprof JANE Maguire, Conjoint Professor Parker Magin, Associate Professor Sarah Johnson, Professor John Attia
Scheme NSW MRSP Infrastructure Grant
Role Investigator
Funding Start 2016
Funding Finish 2016
GNo G1600733
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

SMS4dadsDefence Health$64,120

Funding body: Defence Health Foundation

Funding body Defence Health Foundation
Project Team Associate Professor Richard Fletcher, Doctor Chris May, Doctor Geoffrey Skinner, Associate Professor Frances Kay-Lambkin, Professor John Attia, Professor Brian Kelly
Scheme Booster Grant
Role Investigator
Funding Start 2016
Funding Finish 2017
GNo G1601266
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

SMS4dadsRCT$49,858

Funding body: Beyond Blue Ltd

Funding body Beyond Blue Ltd
Project Team Associate Professor Richard Fletcher, Doctor Chris May, Doctor Geoffrey Skinner, Associate Professor Frances Kay-Lambkin, Professor John Attia, Professor Jan Nicholson, Professor Louise Newman, Professor Brian Kelly, Associate Professor Adrian Dunlop, Professor Alan Hayes
Scheme Research Grant
Role Investigator
Funding Start 2016
Funding Finish 2017
GNo G1601020
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

A novel biomarker and innovative therapeutic strategy for oesophageal cancer$48,677

Funding body: Hunter New England Local Health District

Funding body Hunter New England Local Health District
Project Team Professor Hubert Hondermarck, Professor Marjorie Walker, Doctor Vanessa Wills, Doctor Phil Jobling, Professor John Attia, Professor Robert Rush
Scheme Project Grant
Role Investigator
Funding Start 2016
Funding Finish 2016
GNo G1601109
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

2016 International Visitor from University of Sheffield, UK$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor John Attia, Professor Michael Campbell
Scheme International Research Visiting Fellowship
Role Lead
Funding Start 2016
Funding Finish 2016
GNo G1500955
Type Of Funding Internal
Category INTE
UON Y

20155 grants / $2,287,186

Helping stroke physicians choose who to thrombolyse - the "Targeting Optimal Thrombolysis Outcomes" (TOTO) study$1,069,514

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Liz Holliday, Aprof JANE Maguire, Associate Professor Vincent Thijs, Dr Simon Koblar, Conjoint Associate Professor Jonathan Sturm, Professor John Attia, Doctor Lisa Lincz, Doctor Andrew Bivard
Scheme Project Grant
Role Investigator
Funding Start 2015
Funding Finish 2019
GNo G1400237
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

A practice change intervention to increase the provision of antenatal care addressing maternal alcohol consumption during pregnancy: a stepped-wedge trial$779,672

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor John Wiggers, Professor Elizabeth Elliott, Associate Professor Adrian Dunlop, Professor Ian Symonds, Professor John Attia, Doctor Luke Wolfenden, Professor Chris Rissel
Scheme Partnership Projects
Role Investigator
Funding Start 2015
Funding Finish 2020
GNo G1500584
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

A practice change intervention to increase the provision of antenatal care addressing maternal alcohol consumption during pregnancy: a stepped-wedge trial$318,000

Funding body: Hunter New England Local Health District

Funding body Hunter New England Local Health District
Project Team Professor John Wiggers, Professor Elizabeth Elliott, Associate Professor Adrian Dunlop, Professor Ian Symonds, Professor John Attia, Doctor Luke Wolfenden, Professor Chris Rissel
Scheme Partnership Projects Partner Funding
Role Investigator
Funding Start 2015
Funding Finish 2019
GNo G1500682
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

A practice change intervention to increase the provision of antenatal care addressing maternal alcohol consumption during pregnancy: a stepped-wedge trial$80,000

Funding body: NSW Office of Preventative Health

Funding body NSW Office of Preventative Health
Project Team Professor John Wiggers, Professor Elizabeth Elliott, Associate Professor Adrian Dunlop, Professor Ian Symonds, Professor John Attia, Doctor Luke Wolfenden, Professor Chris Rissel
Scheme Partnership Projects Partner Funding
Role Investigator
Funding Start 2015
Funding Finish 2019
GNo G1500683
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

A practice change intervention to increase the provision of antenatal care addressing maternal alcohol consumption during pregnancy: a stepped-wedge trial$40,000

Funding body: Foundation for Alcohol Research and Education

Funding body Foundation for Alcohol Research and Education
Project Team Professor John Wiggers, Professor Elizabeth Elliott, Associate Professor Adrian Dunlop, Professor Ian Symonds, Professor John Attia, Doctor Luke Wolfenden, Professor Chris Rissel
Scheme Partnership Projects Partner Funding
Role Investigator
Funding Start 2015
Funding Finish 2019
GNo G1500681
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20148 grants / $3,043,679

Does pneumococcal vaccination protect against cardiovascular disease? $1,840,507

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor John Attia, Professor Catherine D'Este, Dr Walter Abhayaratna, Professor Andrew Tonkin, Conjoint Professor Chris Levi, Conjoint Professor David Durrheim, Professor Joseph Hung, Associate Professor Mark McEvoy, Doctor Alexis Hure
Scheme Project Grant
Role Lead
Funding Start 2014
Funding Finish 2019
GNo G1300127
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Reducing unnecessary ordering of pathology tests in hospitalised patients$372,927

Funding body: HCF Health and Medical Research Foundation

Funding body HCF Health and Medical Research Foundation
Project Team Professor John Attia, Conjoint Professor Christopher Doran, Caprf ANDREW Searles, Laureate Professor Robert Sanson-Fisher, Conjoint Professor Anne Duggan, Conjoint Associate Professor Huy Tran, Mr Nigel Lyons, Ms Tracy McCosker, Doctor Alexis Hure
Scheme Health Services Research Grants Program
Role Lead
Funding Start 2014
Funding Finish 2017
GNo G1301000
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Reducing unnecessary ordering of pathology tests in hospitalised patients$372,927

Funding body: HCF Health and Medical Research Foundation

Funding body HCF Health and Medical Research Foundation
Project Team Professor John Attia, Conjoint Professor Christopher Doran, Caprf ANDREW Searles, Laureate Professor Robert Sanson-Fisher, Conjoint Professor Anne Duggan, Conjoint Associate Professor Huy Tran, Mr Nigel Lyons, Ms Tracy McCosker, Doctor Alexis Hure
Scheme Health Services Research Grants Program
Role Lead
Funding Start 2014
Funding Finish 2017
GNo G1301000
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Evaluation of a tailored online hospital and post-discharge smoking cessation program for orthopaedic trauma surgery patients$370,818

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Billie Bonevski, Professor Zsolt Balogh, Professor Amanda Baker, Professor Ian Harris, Professor John Attia, Conjoint Professor Christopher Doran, Dr Johnson George, Doctor Luke Wolfenden
Scheme Partnership Projects
Role Investigator
Funding Start 2014
Funding Finish 2017
GNo G1300686
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Genetic and Environmental Determinants of Depressive Symptoms: Trajectory and Outcomes in a Longitudinal Population Data Set$30,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Brian Kelly, Associate Professor Paul Tooney, Laureate Professor Rodney Scott, Professor John Attia, Professor Murray Cairns, Professor Vaughan Carr
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1400594
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Biological characterisation of genetic associations for large artery atherosclerotic stroke$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Liz Holliday, Laureate Professor Rodney Scott, Conjoint Professor Chris Levi, Professor John Attia, Aprof JANE Maguire
Scheme Stroke Research Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301340
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

The role of perceived stress on the onset of type 2 diabetes in women.$21,500

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Melissa Harris, Professor John Attia, Doctor Judy Luu, Professor Deb Loxton
Scheme Research Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301440
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

A descriptive observational study of infants aged < 24 months with severe bronchiolitis requiring critical care$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Elizabeth Kepreotes, Professor Joerg Mattes, Doctor Peter Harrigan, Conjoint Associate Professor Bruce Whitehead, Professor John Attia, Doctor Mark Lee
Scheme Critical Care and HMRI BRICs Nursing Research and Innovation Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1401451
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20134 grants / $150,000

A genome wide association study on childhood brain tumours$115,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Laureate Professor Rodney Scott, Doctor Frank Alvaro, Miss Tiffany Evans, Professor John Attia, Doctor Liz Holliday, Dr Elizabeth Milne, Professor Bruce Armstrong
Scheme Research Grant
Role Investigator
Funding Start 2013
Funding Finish 2015
GNo G1301149
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Hunter Community Study$15,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor John Attia
Scheme Project Grant
Role Lead
Funding Start 2013
Funding Finish 2015
GNo G1300200
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

The genetic determinants of brain haemorrhage associated with stroke thrombolysis$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Chris Levi, Professor John Attia, Doctor Liz Holliday, Dr Simon Koblar, Laureate Professor Rodney Scott, Conjoint Associate Professor Jonathan Sturm, Associate Professor Jonathan Rosand, Doctor Lisa Lincz, Aprof JANE Maguire
Scheme Near Miss Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300475
Type Of Funding Internal
Category INTE
UON Y

The genetic determinants of brain haemorrhage associated with stroke thrombolysis$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi, Professor John Attia, Doctor Liz Holliday, Dr Simon Koblar, Laureate Professor Rodney Scott, Conjoint Associate Professor Jonathan Sturm, Associate Professor Jonathan Rosand, Doctor Lisa Lincz, Aprof JANE Maguire
Scheme Near Miss
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300704
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20125 grants / $1,191,242

An olfactory 'stress test' for early detection of Alzheimer's disease$775,073

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Schofield, Professor John Attia, Professor Alison Jones, Conjoint Associate Professor Grant Bateman
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2015
GNo G1100221
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Double blind randomised controlled trial of electronic alcohol screening and brief intervention (e-SBI) for hospital outpatients$370,169

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Kypros Kypri, Doctor Natalie Johnson, Professor John Saunders, Professor Richard Saitz, Professor John Attia
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2015
GNo G1100111
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Validation of the food frequency questionnaire used in the Hunter Community Study using carotenoids and fatty acids$25,000

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Alexis Hure, Professor John Attia, Associate Professor Mark McEvoy
Scheme Research Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200266
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

The genetic determinants of brain haemorrhage associated with stroke thrombolysis$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Chris Levi, Professor John Attia, Doctor Liz Holliday, Laureate Professor Rodney Scott, Conjoint Associate Professor Jonathan Sturm, Doctor Lisa Lincz
Scheme Near Miss Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200675
Type Of Funding Internal
Category INTE
UON Y

Plasma protein profiles in normal brain ageing and early stages of dementia$1,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Perminder Sachdev, Dr Anne Poljak, Professor John Attia, Conjoint Professor Peter Schofield, Dr John Crawford, Professor Mark Duncan
Scheme Discovery Projects
Role Lead
Funding Start 2012
Funding Finish 2014
GNo G1200767
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

20111 grants / $1,075,461

Implementation of quality use of advanced CT imaging in acute stroke$1,075,461

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Mark Parsons, Conjoint Professor Chris Levi, Professor Geoff Donnan, Professor Stephen Davis, Professor John Attia, Professor Christopher Bladin, Mr Qing Yang, Associate Professor Peter Mitchell, Associate Professor Stacy Goergen, Professor Ramamohanarao Kotagiri
Scheme Partnership Projects
Role Investigator
Funding Start 2011
Funding Finish 2015
GNo G1000535
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

201010 grants / $1,946,277

Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice. A cluster randomised controlled trial in acute stroke care$800,532

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Robert Sanson-Fisher, Conjoint Professor Chris Levi, Associate Professor Christine Paul, Conjoint Professor Cate d'Este, Professor Mark Parsons, Professor Christopher Bladin, Professor Richard Lindley, Professor John Attia
Scheme Partnership Projects
Role Investigator
Funding Start 2010
Funding Finish 2016
GNo G0189781
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Men, Depression and Social Networks in Rural Communities: Linking Epidemiologic Evidence to Effective Interventions$324,809

Funding body: Beyond Blue Ltd

Funding body Beyond Blue Ltd
Project Team Professor Brian Kelly, Professor John Attia, Associate Professor Frances Kay-Lambkin, Conjoint Associate Professor Terry Lewin, Professor Amanda Baker, Mr Trevor Hazell, Doctor Kerry Inder
Scheme Research Grant
Role Investigator
Funding Start 2010
Funding Finish 2012
GNo G1000456
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Xstrata Coal Fellow in Depression$300,000

Funding body: Xstrata Coal Australia Pty Ltd

Funding body Xstrata Coal Australia Pty Ltd
Project Team Professor Brian Kelly, Professor John Attia, Associate Professor Frances Kay-Lambkin, Conjoint Associate Professor Terry Lewin, Professor Amanda Baker, Mr Trevor Hazell, Doctor Kerry Inder
Scheme Xstrata Coal Fellow in Depression
Role Investigator
Funding Start 2010
Funding Finish 2012
GNo G0900102
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Genetic associations of early retinal pathologic phenotypes: Data pooling and meta-analyses of multiple populations$182,438

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Jie Wang, Professor Eric Boerwinkle, Dr Gerald Liew, Professor Pablo Moscato, Dr Shyong Tai, Dr Alexander Hewitt, Professor John Attia, Associate Professor Yik Teo, Professor Ronald Klein, Doctor Patrick McElduff
Scheme Project Grant
Role Lead
Funding Start 2010
Funding Finish 2012
GNo G1101153
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Experimental Studies of the Effects of the Research Process on Participant Behaviour$178,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Kypros Kypri, Dr Jim McCambridge, Professor John Attia, Mr Steven Bowe
Scheme Discovery Projects
Role Investigator
Funding Start 2010
Funding Finish 2012
GNo G0190025
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Persistence of depressive symptoms and factors associated with depressive symptoms, across urban, rural and regional communities$55,500

Funding body: Australian Rotary Health

Funding body Australian Rotary Health
Project Team Professor Brian Kelly, Professor John Attia, Doctor Kerry Inder
Scheme Mental Health Research Grant
Role Investigator
Funding Start 2010
Funding Finish 2013
GNo G0900233
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice. A cluster randomised controlled trial in acute stroke care $50,000

Funding body: Victorian Department of Health

Funding body Victorian Department of Health
Project Team Laureate Professor Robert Sanson-Fisher, Conjoint Professor Chris Levi, Associate Professor Christine Paul, Conjoint Professor Cate d'Este, Professor Mark Parsons, Professor Christopher Bladin, Professor Richard Lindley, Professor John Attia
Scheme Project Grant
Role Investigator
Funding Start 2010
Funding Finish 2014
GNo G1100824
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Implementation of thrombolytic therapy in acute stroke. A cluster randomised trial$30,000

Funding body: BellBerry Limited

Funding body BellBerry Limited
Project Team Conjoint Professor Chris Levi, Professor John Attia, Associate Professor Christine Paul, Professor Mark Parsons, Professor Christopher Bladin, Professor Richard Lindley, Conjoint Professor Cate d'Este
Scheme Near Miss
Role Investigator
Funding Start 2010
Funding Finish 2014
GNo G0900221
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Zinc as a target for prevention of type-2 diabetes$15,000

Funding body: Hunter Children`s Research Foundation

Funding body Hunter Children`s Research Foundation
Project Team Professor John Attia, Doctor Milton Hasnat, Associate Professor Mark McEvoy, Doctor Amanda Patterson, Doctor Sham Acharya, Mr Steven Bowe
Scheme Research Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G1000450
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Genetic influences in colorectal cancer: a global consortium$9,998

Funding body: Hunter Children`s Research Foundation

Funding body Hunter Children`s Research Foundation
Project Team Laureate Professor Rodney Scott, Professor John Attia, Associate Professor Mark McEvoy
Scheme Research Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0900152
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20095 grants / $1,419,923

Australian stroke genetics collaborative - Genome-wide association study in ischaemic stroke$1,108,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Chris Levi, Conjoint Associate Professor Jonathan Sturm, Professor John Attia, Laureate Professor Rodney Scott, Doctor Lisa Lincz, Dr Simon Koblar, Professor Pablo Moscato
Scheme Project Grant
Role Investigator
Funding Start 2009
Funding Finish 2011
GNo G0188856
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

LDX analyser (fingerprick unit) x4, piCo Smokerlyzer (Carboxymeter)x4, Universal cardboard disposable mouthpieces for piCo smokerlyzer x4 and Universal d pieces for piCo Smokerlyzer x4$20,775

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Amanda Baker, Associate Professor Frances Kay-Lambkin, Doctor Alyna Turner, Associate Professor Juanita Todd, Professor Robin Callister, Doctor Sally Hunt, Professor Brian Kelly, Professor John Attia, Professor Jennifer Bowman, Doctor Paula Wye
Scheme Equipment Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189849
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Development and transfer of data linkage key and dataset for SHOAMP data and blood samples$13,387

Funding body: Department of Veterans` Affairs

Funding body Department of Veterans` Affairs
Project Team Conjoint Professor Cate d'Este, Professor John Attia
Scheme Research Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G1000008
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Vascular Ischaemia Study$10,400

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi, Professor John Attia, Laureate Professor Rodney Scott, Doctor Michael Seldon, Doctor Lisa Lincz, Conjoint Associate Professor Jonathan Sturm
Scheme Research Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0900120
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20082 grants / $861,224

Genes and environment in the risk of early age-related macular degeneration: a population-based case-control study$701,224

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor John Attia, Conjoint Professor Wayne Smith, Professor Pablo Moscato
Scheme Project Grant
Role Lead
Funding Start 2008
Funding Finish 2010
GNo G0189168
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

HMRI Senior Research Fellow$160,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor John Attia, Emeritus Professor Maree Gleeson, Laureate Professor Rodney Scott, Conjoint Professor Vaughan Carr, Conjoint Professor Stephen Ackland, Professor Michael Hazelton, Professor Trevor Day
Scheme Senior Fellowship
Role Lead
Funding Start 2008
Funding Finish 2009
GNo G0188558
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20077 grants / $219,708

Systematic Review of the effects of Long Work Hours on Workplace Safety & Performance$69,000

Funding body: National Occupational Health & Safety Commission

Funding body National Occupational Health & Safety Commission
Project Team

Maya Guest

Scheme Tender
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON N

Prevention of heart disease by pneumococcal vaccination$50,000

Funding body: Pfizer Australia

Funding body Pfizer Australia
Project Team Professor Phil Hansbro, Dr Sukumaran Thambar, Professor John Attia, Associate Professor Mark McEvoy
Scheme Cardiovascular Lipid Research Grants
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0186642
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Cancer Cluster Study$48,030

Funding body: Newcastle Innovation

Funding body Newcastle Innovation
Project Team Doctor Maya Guest, Ms Sandra McBurnie, Professor John Attia, Conjoint Professor Cate d'Este
Scheme Administered Research
Role Investigator
Funding Start 2007
Funding Finish 2008
GNo G0188347
Type Of Funding Internal
Category INTE
UON Y

Healthy Airways and Obstructive Lung Disease (HAROLD)$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Wayne Smith, Professor Lisa Wood, Professor John Attia, Professor Regina Berretta, Professor Pablo Moscato
Scheme Project Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187246
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Hewlett Packard 7890 series gas chromatograph with accessories$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Lisa Wood, Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Professor Jodie Simpson, Doctor Vanessa Murphy, Laureate Professor Paul Foster, Professor Phil Hansbro, Conjoint Associate Professor Vicki Clifton, Professor Clare Collins, Conjoint Professor Wayne Smith, Professor John Attia
Scheme Equipment Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188191
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

The impact of Asymmetrical Dimethylarginine on Cognition in a population-based cohort$7,678

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Mark McEvoy, Conjoint Professor Wayne Smith, Conjoint Professor Peter Schofield, Professor John Attia
Scheme Pilot Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187872
Type Of Funding Internal
Category INTE
UON Y

Genetic polymorphisms in the native thrombolytic systems as risk factors for ischaemic stroke.$5,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi, Professor John Attia, Laureate Professor Rodney Scott, Dr Amanda Thrift
Scheme Research Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187320
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20068 grants / $748,641

Prevention of heart disease by pneumococcal vaccination$55,000

Funding body: Pfizer Cardiovascular lipid research grants

Funding body Pfizer Cardiovascular lipid research grants
Project Team

Suku Thambar

Scheme Cardiovascular Lipid Research Grants
Role Investigator
Funding Start 2006
Funding Finish 2007
GNo
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON N

The impact of Anticholinergic activity, apolipoprotein E and high-affinity choline transporter genotype on cognition in a population-based co-hort: a pilot study$15,500

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Mark McEvoy, Conjoint Professor Peter Schofield, Conjoint Professor Wayne Smith, Doctor Janine Duke, Professor John Attia
Scheme Project Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186170
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

The rEMISS Study. Exploring the Experience of Mood Disturbance in community dwelling Stroke Survivors: a longitudinal study$14,500

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team

Chris Levi

Scheme Charitable Trusts and Foundations Project
Role Investigator
Funding Start 2006
Funding Finish 2007
GNo
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON N

Is pneumococcal vaccination protective for cardiovascular disease? Elucidating the relationship between pneumococcal vaccination and protective anti-oxidised LDL antibodies$13,448

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor John Attia
Scheme Pilot Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0186696
Type Of Funding Internal
Category INTE
UON Y

Elucidating the mechanics of transgenerational toxicity in the ageing male$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Shaun Roman, Professor John Attia, Dr Elizabeth Gillam
Scheme Near Miss Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186080
Type Of Funding Internal
Category INTE
UON Y

10 year follow-up of patients attending a flexible eating insulin education program$10,000

Funding body: Novo Nordisk Foundation

Funding body Novo Nordisk Foundation
Project Team

Julia Lowe

Scheme Project Grant
Role Investigator
Funding Start 2006
Funding Finish 2007
GNo
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON N

Identification of single nucleotide polymorphisms that are associated with an increased risk of colectoral cancer$9,050

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Laureate Professor Rodney Scott, Professor Robyn Ward, Assoc. Prof Nicholas Hawkins, Professor John Attia, Conjoint Professor David Sibbritt, Professor Pablo Moscato
Scheme Near Miss Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186073
Type Of Funding Internal
Category INTE
UON Y

20054 grants / $166,088

Genetic polymorphisms in the native thrombolytic and thrombotic systems as risk factors for ischaemic stroke$106,488

Funding body: National Heart Foundation of Australia

Funding body National Heart Foundation of Australia
Project Team Conjoint Professor Chris Levi, Professor John Attia, Laureate Professor Rodney Scott, Dr Amanda Thrift
Scheme Grant-In-Aid
Role Investigator
Funding Start 2005
Funding Finish 2006
GNo G0184034
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Prevalence and risk factors for peripheral neuropathy in newly-diagnosed type 2 diabetes$30,000

Funding body: Diabetes Australia

Funding body Diabetes Australia
Project Team Conjoint Professor Wayne Smith, Professor John Attia, Conjoint Associate Professor Julia Lowe, Doctor Janine Duke
Scheme Research Grant
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0185002
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

The effect of dietary folate, environmental toxins, and genetic polymorphisms in parents and children in determining the risk of childhood acute lymphoblastic leukaemia$20,000

Funding body: Royal Australasian College of Physicians

Funding body Royal Australasian College of Physicians
Project Team Professor John Attia, Doctor Anne Ronan
Scheme Arnott Fellowship in Cancer Research
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0185060
Type Of Funding Not Known
Category UNKN
UON Y

Kryos cryogenic vessel controller$9,600

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team

McEvoy

Scheme Infrastructure Grants
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo
Type Of Funding Not Known
Category UNKN
UON N

20044 grants / $256,065

Nature, nuture and acute childhood lymphoblastic leukaemia$193,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Rodney Scott, Professor John Attia
Scheme Project Grant
Role Investigator
Funding Start 2004
Funding Finish 2006
GNo G0183209
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Ambient baroque music in dementia$30,000

Funding body: Bernard Judd Foundation

Funding body Bernard Judd Foundation
Project Team Professor Kichu Nair, Professor John Attia, Conjoint Professor John Marley
Scheme Research Grant
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0184809
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Novel genetic and environmental risk factors in atherothrombosis: The role of variation in Cox-2, tpA and PAI-1 activity$28,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi, Conjoint Professor David Henry, Dr Patricia McGettigan, Professor John Attia, Professor Mark Parsons, Dr Michael Seldon, Laureate Professor Rodney Scott
Scheme Research Grant
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0183749
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Visit of Mrs Ammarin Thakkinstain 1 March 2004 to 30 May 2004$4,565

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor John Attia
Scheme Visitor Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0183802
Type Of Funding Internal
Category INTE
UON Y

20031 grants / $195,000

Research Fellows in Epidemiology$195,000

Funding body: Vicent Fairfax Family Foundation

Funding body Vicent Fairfax Family Foundation
Project Team Professor Julie Byles, Professor John Attia, Conjoint Professor Wayne Smith
Scheme Research Grant
Role Investigator
Funding Start 2003
Funding Finish 2005
GNo G0182726
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20024 grants / $1,173,786

Study of health outcomes in aircraft maintenance personnel (Phase II and III)$893,786

Funding body: Commonwealth department of veterans affairs

Funding body Commonwealth department of veterans affairs
Project Team

Catherine D'Este

Scheme Tender
Role Investigator
Funding Start 2002
Funding Finish 2004
GNo
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON N

Study of health outcomes in aircraft maintenance personnel (Phase I)$275,000

Funding body: Commonwealth department of veterans affairs

Funding body Commonwealth department of veterans affairs
Project Team

Catherine D'Este

Scheme Tender
Role Investigator
Funding Start 2002
Funding Finish 2003
GNo
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON N

American-Heart Association/Asia Pacific Scientific Forum, Hawaii, 23-26 April 2002$2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor John Attia
Scheme Travel Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0181696
Type Of Funding Internal
Category INTE
UON Y

World Congress of Epidemiology, Montreal, Canada 18-22 August, 2002$2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor John Attia
Scheme Travel Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0182156
Type Of Funding Internal
Category INTE
UON Y

20012 grants / $68,600

The Genetic Origins of Childhood Cancer.$40,000

Funding body: John Hunter Children`s Hospital Research Foundation

Funding body John Hunter Children`s Hospital Research Foundation
Project Team Laureate Professor Rodney Scott, Professor John Attia, Doctor Frank Alvaro
Scheme Research Grant (Defunct)
Role Investigator
Funding Start 2001
Funding Finish 2001
GNo G0181219
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Development of two courses in molecular and genetic epidemiology.$28,600

Funding body: Commonwealth Department of Health & Aged Care

Funding body Commonwealth Department of Health & Aged Care
Project Team Professor John Attia, Professor Julie Byles
Scheme Innovative Projects in Relation to PHERP
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0180974
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20001 grants / $9,200

The effect of angiotensin-converting enzyme gene variants on survival post-myocardial infarction and on response to ACE inhibitors.$9,200

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor John Attia
Scheme Early Career Researcher Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0179327
Type Of Funding Internal
Category INTE
UON Y

19981 grants / $96,480

Tea tree oil as a topical decolonisation solution for adult inpatients with Methicillin-resistant Staphylococcus Aureas$96,480

Funding body: Rural Industries Research & Development Corporation

Funding body Rural Industries Research & Development Corporation
Project Team Professor John Attia, Meredith Caelli, Assoc. Prof T Riley
Scheme Research and Development Project
Role Lead
Funding Start 1998
Funding Finish 2000
GNo G0177627
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y
Edit

Research Supervision

Number of supervisions

Completed20
Current18

Total current UON EFTSL

Masters0.15
PhD2.83

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2017 PhD Management of Weight and Health in Type II Diabetes. PhD (Nutrition & Dietetics), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2017 PhD Olfaction, The Olfactory Stress Test and Cognition in Community Dwelling Elders PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2017 Masters The Impact of Reduction in Left Ventricular End Diastolic Pressure in Patients with ST-segment Elevation Myocardial Infarction. M Philosophy (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2017 PhD Occupational Exposure and Chronic Disease in the Hunter Valley PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2017 PhD The Aim of the Study is to Compare Quality and Cost of Care in the Public and Private Systems for a Number of Common Conditions. PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2017 PhD An Exploration of Strategies to Enhance the Care of Acutely Unwell Older People: A System Wide Model of Care PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2017 PhD Measuring Research Impact in Australia's Medical Research Institutes PhD (Behavioural Science), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2016 Masters Heart Failure Outcomes in Hunter New England Area M Philosophy (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2016 PhD IS RISK-BASED LICENSING EFFECTIVE IN REDUCING ASSAULTS? PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2015 PhD Can Individualized Blood Pressure (BP) Targets Reduce the Incidence of New-Onset Acute Kidney Injury Among Critically Ill Patients With Shock? PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2014 PhD Defining the Immune System and Preventable Mortality in Geriatric Hip Fractures PhD (Surgical Science), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2014 PhD Antenatal Weighing and Gestational Weight Gain PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2014 PhD Smoke-Free Recovery: Smoking Cessation for Hospitalised Patients PhD (Behavioural Science), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2014 PhD Modifiable Parent Factors in the Initiation of Adolescent Risky Drinking
Sonia Sharmin
PhD (Behavioural Science), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2013 PhD Impact of Dietary Protein on Postprandial Blood Glucose Levels in Type 1 Diabetes Mellitus PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2012 PhD Genetic And Non-Genetic Studies Of Type 2 Diabetes In Three Susceptible Asian Populations: Malay, Chinese And Indian PhD (Medical Genetics), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2012 PhD Potential Cardio-Protective Effect of Pneumococcal Vaccine PhD (Clinical Pharm), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2012 PhD The Role of Autoimmunity and Inflammation in Chronic Disease PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle Principal Supervisor

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2016 PhD Diet and Depression in Community-Dwelling Adults PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle Principal Supervisor
2015 PhD Health Determinants in Australian Communities: A Multilevel Investigation of the Influence of Personal and Contextual Characteristics PhD (Psychiatry), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2015 PhD The Role of Zinc in Chronic Disease PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2015 PhD Environmental Determinants of Lupus Flares PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2014 PhD Exploring the Long-Term Experience of Psychological Morbidity in Community-Dwelling Stroke Survivors PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2014 PhD The Inflammation Hypothesis of Depression: Cross Sectional Associations, Temporal Relationships and the Confounds of Comorbidity PhD (Psychiatry), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2014 PhD The Optimal Timing of Surgical Fracture Stabilization in Trauma Patients PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2014 Masters The Relationship Between Early Alzheimer's Disease, Apolipoprotein E Genotyping & Hippocampal MRI Volumes M Philosophy (ComMed&ClinEpid), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2013 PhD Suicide in Urban and Rural Australia: Determinants, Moderators and Treatment Options for Suicidal Thoughts and Behaviours PhD (Psychiatry), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2012 Masters Systematic Review and Network Meta-Analysis of Intravenous Ibuprofen Vs. Intravenous Indomethacin Vs. Placebo in the Management of Clinically and/or Echocardiographically Important Patent Ductus Arteriosus in Preterm Infants at Greater than 24 Hours of Life M Philosophy (ComMed&ClinEpid), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2012 PhD Factor V Leiden and Adverse Pregnancy Outcome PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle Sole Supervisor
2012 PhD The Food and Nutrient Intake and Physical Activity of Australian Aboriginal and Torres Strait Islander and Non-Indigenous Rural Children PhD (Behavioural Science), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2012 PhD The Study of Health Outcomes in Aircraft Maintenance Personnel: Sensory System Effects PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2010 PhD The Clinical Efficacy of Tea Tree Oil as an Alternative Topical Decolonisation Agent for Adult Inpatients with Meticillin-Resistant Staphylococcus Aureus PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle Sole Supervisor
2010 PhD Genetic Polymorphisms of Platelet Glycoprotein and Cyclooxygenase-2 Genes and Their Influence on Risk of Ischaemic Stroke, 90 Day Post-Stroke Outcome, and Gene-Environment Interactions PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2007 PhD Clinical Epidemiology of B Natriuretic Peptides as Tests for Heart Failure in Australian General Practice PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2006 PhD Cardiovascular Risk Factors in Asians and Caucasians PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2004 PhD Meta-analysis of Molecular Association Studies PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle Principal Supervisor
2004 PhD Molecular Epidemiological Study of Childhood Cancer PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle Principal Supervisor
2003 PhD Diet, Lifestyle, and Risk Factors for Forearm Fracture in Postmenopausal Women PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle Principal Supervisor
Edit

Research Projects

Humira and Endothelial Function in Rheumatoid Arthritis 2 (HEART RA - 2) 2015 -

Hunter HEART-RA will answer many questions regarding cardiovascular disease in ACPA-positive RA. However, it will not evaluate ACPA-negative RA patient group and cannot answer the question of when, at which stage in the development of RA, cardiovascular risk becomes elevated and which inflammatory and non-inflammatory processes may be responsible. Hunter HEAT-RA-2 has been designed to investigate these questions in greater detail. 

Hunter HEART-RA-2 is an extension of Hunter HEART-RA consisting of 2 parts.

Part 1: Randomised Controlled Trial evaluating the Effect of the TNF-Inhibitor drug Humira (adalimumab) upon cardiovascular risk as measured by a platform of cardiovascular assessments. This second study will include ACPA-negative RA patients and more comprehensive assessments of cardiovascular function and inflammatory burden.

Part 2: Cross-Sectional Study evaluating cardiovascular risk in First Degree Relatives of patients with Rheumatoid Arthritis, Healthy Unrelated Controls and people with immunological markers of rheumatoid arthritis without clinical disease.  

In both parts of this study there will be a platform of assessments of articular inflammation, cardiovascular function and laboratory assessments. In addition to the routine assessments of inflammatory burden (clinical joint counts, ESR and CRP) musculoskeletal ultrasound will be used to detect subclinical joint inflammation.  The platform of cardiovascular assessments include endothelial function (EndoPAT), central arterial pressure indices, aortic stiffness (carotid-femoral pulse wave velocity) and carotid ultrasound (carotid intimal medial thickness and carotid plaque measurement). Participants will have a range of genetic and immunological tests and a sub-group will participate in studies of NETosis. 

Grants

Humira and Endothelial Function in Rheumatoid Arthritis - 2 (HEART-RA-2)

Funding body: Abbvie Pharmaceuticals

Funding body Abbvie Pharmaceuticals
Description

Interim analysis in Hunter HEART-RA-1 confirmed that endothelial function correlates inversely with inflammatory burden in patients with anti-CCP positive rheumatoid arthritis (RA). However, it appears that other disease-specific but non-inflammatory mechanisms may contribute to cardiovascular disease in RA. This might include genetic factors, abnormalities of lipid transport and newly described immune mechanisms such as NETosis. HEART-RA-1 also only evaluated patients with anti-CCP positive RA. 

HEART-RA-2 will consist of 2 parts:

Part 1, a randomised controlled trial will evaluate the effect of Humira upon endothelial function in anti-CCP antibody positive and anti-CCP antibody negative patients with RA. 

Part 2 will evaluate non-inflammatory mechanisms of cardiovascular disease by taking inflammation out of the equation. This will be done by studying people with Pre-RA i.e. who have evidence of RA on blood test of on ultrasound but no clinical evidence of RA.

Scheme Abbvie Investigator-Initiated Grant

Collaborators

Name Organisation
Professor John Richard Attia University of Newcastle
Professor Phil Michael Hansbro University of Newcastle

Edit

News

PhD Opportunity - Biomarker for early Alzheimer's disease

PhD Opportunity - Biomarker for early Alzheimer's disease

October 20, 2017

A PhD opportunity exists for someone with biological and analytic skills who would be interested in taking advantage of collected data from an NHMRC funded study focussed on a novel potential biomarker for early Alzheimer's disease under the supervision of Conjoint Associate Professor Peter Schofield and Professor John Attia.

sleep

sleep linked to diabetes

December 12, 2013

Getting less than six hours sleep each night (compared to seven hours) may increase type 2 diabetes risk by 30 per cent but has less impact on heart disease than previously thought, researchers from the University of Newcastle have found.

HMRI

New study shows genetic role in education

May 31, 2013

A multinational consortium of medical researchers and social scientists has found a link between educational attainment and tiny variations in a person's genetic sequence.

Professor John Attia

Position

Academic Director
CReDITSS Unit
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Email john.attia@newcastle.edu.au
Phone (02) 4042 0500
Fax (02) 40420039

Office

Room 3014
Building Hunter Medical Research Institute Building
Location Kookaburra Circuit, John Hunter Hospital Campus New Lambton NSW 2305

,
Edit