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Dr Jennette Sakoff

Conjoint Lecturer

School of Environmental and Life Sciences (Chemistry)

Career Summary

Biography

Research Expertise
Dr Sakoff is an experienced cell biologist and Chief Hospital Scientist in the Department of Medical Oncology at the Calvary Mater Newcastle Hospital. Dr Sakoff is the leader of the Experimental Therapeutics Group. She has made significant contributions to cancer research particularly in the development of small molecules for the treatment of cancer. Areas of expertise includes cell culture, drug screening, cell biology, proteomics, cell cycle analysis, drug combination studies, clinical toxicity.

Teaching Expertise
Selected lectures in drug development.

Qualifications

  • PhD, University of Newcastle

Keywords

  • Breast Cancer
  • Cancer
  • Chemotherapy
  • Drug Development
  • Dynamin
  • Glioblastoma
  • PP2A

Fields of Research

Code Description Percentage
111299 Oncology and Carcinogenesis not elsewhere classified 100

Professional Experience

Professional appointment

Dates Title Organisation / Department
1/01/2016 -  Chair of Calvary Mater Newcastle Research Committee Calvary Mater Newcastle
Australia
1/02/1996 -  Chief Hospital Scientist Calvary Mater Newcastle Hospital
Medical Oncology
Australia

Awards

Research Award

Year Award
2000 Young medical researcher of the year
Unknown
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Grants and Funding

Summary

Number of grants 32
Total funding $3,526,316

Click on a grant title below to expand the full details for that specific grant.


20171 grants / $25,000

Defining and predicting clinical toxicity in GBM patients undergoing temozolomide-radiation treatment: A multivariate study$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor James Lynam, Doctor Jennette Sakoff, Professor Jennifer Martin, Doctor Lisa Lincz, Doctor Michael Fay, Doctor Peter Galettis
Scheme Project Grant
Role Investigator
Funding Start 2017
Funding Finish 2017
GNo G1700586
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20152 grants / $320,000

The Hunter Cancer Biobank (HCB): Maximising community value through validation, annotation and distribution throughout NSW$300,000

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Professor Marjorie Walker, Conjoint Professor Stephen Ackland, Laureate Professor Rodney Scott, Professor John Forbes, Professor Xu Dong Zhang, Doctor Pradeep Tanwar, Doctor Nikola Bowden, Doctor Craig Gedye, Doctor James Lynam, Doctor Kelly Kiejda, Doctor Jennette Sakoff, Mr Loui Rassam, Dr Tara Roberts, Professor Soon Lee, Dr Betty Kan
Scheme Research Infrastructure Grants
Role Investigator
Funding Start 2015
Funding Finish 2018
GNo G1500825
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

The development of new drugs that selectively target breast cancer$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jennette Sakoff, Professor Adam McCluskey
Scheme Project Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1501381
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20142 grants / $35,000

Enhancing radiation effects for the treatment of brain cancer $25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jennette Sakoff, Dr JAYNE Gilbert, Professor Adam McCluskey
Scheme Project Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1301412
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

An Investigation on the Consensus Between Different Genomic and Transcriptomic Results in Breast Cancer$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Ms Heloisa Milioli, Professor Pablo Moscato, Doctor Jennette Sakoff, Professor Regina Berretta
Scheme Jennie Thomas Medical Research Travel Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1401334
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20132 grants / $233,809

The integration of bioinformatics, chemoinformatics, and toxicogenomics methods: a new approach for the identification of combination tailored therapies and novel drug targets in breast cancer$210,000

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Professor Pablo Moscato, Doctor Jennette Sakoff, Professor Regina Berretta
Scheme NSW Premier's Awards for Outstanding Cancer Research: "Big Data, Big Impact" Grant
Role Investigator
Funding Start 2013
Funding Finish 2014
GNo G1300826
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Testing parallels between placental and cancer cell proliferation and fusion: the role of transcription factories$23,809

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Giavanna Angeli, Doctor Jorge Tolosa Gonzalez, Doctor Brett Locker, Doctor Jennette Sakoff
Scheme Research Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1301207
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

20127 grants / $750,454

The role of clathrin in the spindle assembly checkpoint and as an anticancer target$239,760

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Ms Megan Chircop, Professor Adam McCluskey, Prof Phillip Robinson, Doctor Jennette Sakoff
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2014
GNo G1101106
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

High-Resolution Isoelectric Phosphoprotein Signalling System for Signalling Research, Biomarker Validation and Drug Development – Equipment Grant$143,394

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Rick Thorne, Professor Xu Dong Zhang, Professor Hubert Hondermarck, Conjoint Professor Stephen Ackland, Doctor Lisa Lincz, Doctor Jennette Sakoff, Emeritus Professor Leonie Ashman
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200555
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Identification of a novel target for the treatment of hormone positive breast cancer$30,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jennette Sakoff, Dr JAYNE Gilbert, Professor Adam McCluskey
Scheme Breast Cancer Project Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200716
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Mitotane pharmacodynamics in Adrenocortical Cancer in children and adults $20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Stephen Ackland, Doctor Jennette Sakoff, Ms MADHU Garg
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2013
GNo G1200319
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

The role of clathrin in the spindle assembly checkpoint and as an anticancer target$15,000

Funding body: NSW Trade & Investment

Funding body NSW Trade & Investment
Project Team Professor Adam McCluskey, Doctor Jennette Sakoff
Scheme TechVouchers Program
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200796
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Ultrasonic Homogenizer System and -80 ºC Freezers for chemical and biological sample storage$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Adam McCluskey, Professor Eileen McLaughlin, Professor Peter Lewis, Ms Belinda Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Associate Professor Ian Grainge
Scheme Equipment Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100986
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20115 grants / $1,610,603

Priority Research Centre for Cancer$555,811

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Stephen Ackland, Professor Xu Dong Zhang, Professor John Forbes, Emeritus Professor Leonie Ashman, Doctor Nikola Bowden, Professor Gordon Burns, Conjoint Professor Jim Denham, Professor Hubert Hondermarck, Doctor Lisa Lincz, Doctor Jennette Sakoff, Associate Professor Peter Stanwell, Doctor Rick Thorne, Doctor Nikki Verrills
Scheme Priority Research Centre
Role Investigator
Funding Start 2011
Funding Finish 2016
GNo G1101013
Type Of Funding Internal
Category INTE
UON Y

Development of pthaladyn-based dynamin I-selective inhibitors for treatment of epilepsy$544,831

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Adam McCluskey, Prof Phillip Robinson, Professor Terence O'Brien, Ms Megan Chircop, Doctor Jennette Sakoff
Scheme Development Grants
Role Investigator
Funding Start 2011
Funding Finish 2013
GNo G1000740
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Chemical Biology$444,961

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Adam McCluskey, Doctor Warwick Belcher, Associate Professor Ian Grainge, Professor Christopher Grof, Professor Peter Lewis, Professor Eileen McLaughlin, Doctor Shaun Roman, Emeritus Professor Ray Rose, Doctor Jennette Sakoff, Doctor Nikki Verrills
Scheme Priority Research Centre
Role Investigator
Funding Start 2011
Funding Finish 2015
GNo G1100052
Type Of Funding Internal
Category INTE
UON Y

Computational prediction and functional clarification of novel drug combination strategies for the treatment of brain tumours$50,000

Funding body: Maitland Cancer Appeal Committee

Funding body Maitland Cancer Appeal Committee
Project Team Professor Pablo Moscato, Dr DAN Johnstone, Professor Regina Berretta, Doctor Luke Mathieson, Professor Manuel Graeber, Doctor Jennette Sakoff
Scheme Research Project
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100275
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Eppendorf mastercycler pro with thermomixer comfort and 5430R centrifuge$15,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Eileen McLaughlin, Professor Peter Lewis, Professor Adam McCluskey, Conjoint Professor Keith Jones, Professor Brett Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Associate Professor Ian Grainge, Doctor Janet Bristow, Doctor Xiao Yang
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100028
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20101 grants / $35,000

New small molecules for the treatment of neuroblastoma$35,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Dr JAYNE Gilbert, Doctor Jennette Sakoff, Ms Megan Chircop
Scheme Paediatric Oncology Project Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0900192
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20072 grants / $352,000

FACSAria - Fluorescence activated cell sorter$300,000

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Doctor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
Scheme Research Infrastructure Grants
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187666
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

HMRI Contribution toward FACSAria - Fluorescence activated cell sorter$52,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
Scheme Equipment Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188207
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

20061 grants / $11,000

Overcoming radiation resistance in malignant melanoma$11,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Lisa Lincz, Doctor Jennette Sakoff
Scheme Project Grant
Role Investigator
Funding Start 2006
Funding Finish 2007
GNo G0186528
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20031 grants / $50,000

High Pressure and Fluorous Approaches to fostriecin libraries: New Therapeutic Opportunities.$50,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Adam McCluskey, Assoc. Prof David Young, Doctor Jennette Sakoff
Scheme Discovery Projects
Role Investigator
Funding Start 2003
Funding Finish 2003
GNo G0182117
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

20021 grants / $10,000

New targets for chemotherapy: anti-cancer drugs that target protein phosphatases$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Adam McCluskey, Conjoint Professor Stephen Ackland, Doctor Jennette Sakoff
Scheme Project Grant
Role Investigator
Funding Start 2002
Funding Finish 2002
GNo G0181459
Type Of Funding Internal
Category INTE
UON Y

20013 grants / $23,450

Synergistic interaction between thymidylate synthase and protein phosphatase inhibition in colon cancer cells$10,450

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Jennette Sakoff
Scheme Early Career Researcher Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0181233
Type Of Funding Internal
Category INTE
UON Y

Predicting bone marrow regeneration in cancer patients through the use of telomere quantitative (Q)-FISH$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Lisa Lincz, Doctor Jennette Sakoff
Scheme Lions Club of Stroud
Role Investigator
Funding Start 2001
Funding Finish 2001
GNo G0181502
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Pulse Education Prize for 2001$3,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jennette Sakoff
Scheme Research Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0181503
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20003 grants / $45,000

Influence of Haematopoetic stem cell telorase activity on bone marrow recovery following myoablative therapy.$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Lisa Lincz, Ms Kerry Fagan, Doctor Jennette Sakoff
Scheme Research Grant
Role Investigator
Funding Start 2000
Funding Finish 2000
GNo G0180171
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

A counter-intuitive anticancer treatment.$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jennette Sakoff
Scheme Research Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0180205
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Young Medical Researcher of the Year.$5,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jennette Sakoff
Scheme Research Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0180182
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

19991 grants / $25,000

Selective Inhibitors of Protein Phosphatases as Anti-cancer agents$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jennette Sakoff, Professor Adam McCluskey, Conjoint Professor Stephen Ackland
Scheme Research Grant
Role Lead
Funding Start 1999
Funding Finish 1999
GNo G0178390
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y
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Research Supervision

Number of supervisions

Completed1
Current1

Total current UON EFTSL

PhD0.2

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2016 PhD Development of Morphlocks to Further Understanding of Dynamin's Allosteric Regulation PhD (Chemistry), Faculty of Science, The University of Newcastle Co-Supervisor

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2017 PhD Breast Cancer Intrinsic Subtypes: A Critical Conception in Bioinformatics PhD (Biological Sciences), Faculty of Science, The University of Newcastle Co-Supervisor
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Dr Jennette Sakoff

Position

Conjoint Lecturer
Experimental Therapeutics Group
School of Environmental and Life Sciences
Faculty of Science

Focus area

Chemistry

Contact Details

Email jennette.sakoff@newcastle.edu.au
Phone (02) 40143560
Fax (02) 4968 0384

Office

Room .
Building Department of Medical Oncology
Location Calvary Mater Newcastle Hospital

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