Dr Huw McCarthy
Postdoctoral Researcher
School of Biomedical Sciences and Pharmacy
Career Summary
Biography
Qualifications
- Bachelor of Biomedical Sciences (Hons), University of Newcastle
Keywords
- Cancer Immunology
- Immunology
Languages
- English (Mother)
Fields of Research
Code | Description | Percentage |
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320409 | Tumour immunology | 50 |
320404 | Cellular immunology | 50 |
Professional Experience
UON Appointment
Title | Organisation / Department |
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Postdoctoral Researcher | University of Newcastle School of Biomedical Sciences and Pharmacy Australia |
Publications
For publications that are currently unpublished or in-press, details are shown in italics.
Journal article (3 outputs)
Year | Citation | Altmetrics | Link | ||||||||
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2024 |
Mayall JR, Horvat JC, Mangan NE, Chevalier A, McCarthy H, Hampsey D, et al., 'Interferon-epsilon is a novel regulator of NK cell responses in the uterus', EMBO Molecular Medicine, 16 267-293 [C1]
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2023 |
Mccarthy H, Keely S, 'Re-evaluating the Role of Deep Crypt Secretory Cells in Intestinal Homeostasis', CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 15 1020-1021 (2023)
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2020 |
Lee JM, Mayall JR, Chevalier A, McCarthy H, Van Helden D, Hansbro PM, et al., 'Chlamydia muridarum infection differentially alters smooth muscle function in mouse uterine horn and cervix', American Journal of Physiology - Endocrinology and Metabolism, 318 E981-E994 (2020) [C1] Lee JM, Mayall JR, Chevalier A, McCarthy H, Van Helden D, Hansbro PM, Horvat JC, Jobling P. Chlamydia muridarum infection differentially alters smooth muscle function in mouse ute... [more] Lee JM, Mayall JR, Chevalier A, McCarthy H, Van Helden D, Hansbro PM, Horvat JC, Jobling P. Chlamydia muridarum infection differentially alters smooth muscle function in mouse uterine horn and cervix. Am J Physiol Endocrinol Metab 318: E981 E994, 2020. First published April 21, 2020; doi:10.1152/ajpendo.00513. 2019. Chlamydia trachomatis infection is a primary cause of reproductive tract diseases including infertility. Previous studies showed that this infection alters physiological activities in mouse oviducts. Whether this occurs in the uterus and cervix has never been investigated. This study characterized the physiological activities of the uterine horn and the cervix in a Chlamydia muridarum (Cmu)-infected mouse model at three infection time points of 7, 14, and 21 days postinfection (dpi). Cmu infection significantly decreased contractile force of spontaneous contraction in the cervix (7 and 14 dpi; P < 0.001 and P < 0.05, respectively), but this effect was not observed in the uterine horn. The responses of the uterine horn and cervix to oxytocin were significantly altered by Cmu infection at 7 dpi (P < 0.0001), but such responses were attenuated at 14 and 21 dpi. Cmu infection increased contractile force to prostaglandin (PGF2_) by 53 83% in the uterine horn. This corresponded with the increased messenger ribonucleic acid (mRNA) expression of Ptgfr that encodes for its receptor. However, Cmu infection did not affect contractions of the uterine horn and cervix to PGE2 and histamine. The mRNA expression of Otr and Ptger4 was inversely correlated with the mRNA expression of Il1b, Il6 in the uterine horn of Cmu-inoculated mice (P < 0.01 to P < 0.001), suggesting that the changes in the Otr and Ptger4 mRNA expression might be linked to the changes in inflammatory cytokines. Lastly, this study also showed a novel physiological finding of the differential response to PGE2 in mouse uterine horn and cervix.
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Nova |
Grants and Funding
Summary
Number of grants | 1 |
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Total funding | $4,972 |
Click on a grant title below to expand the full details for that specific grant.
20231 grants / $4,972
Neutrophil Extracellular Traps in Colorectal Cancer$4,972
Funding body: University of Newcastle
Funding body | University of Newcastle |
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Project Team | Doctor Huw McCarthy, Doctor Grace Burns |
Scheme | Pilot Funding Scheme |
Role | Lead |
Funding Start | 2023 |
Funding Finish | 2023 |
GNo | G2300458 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Research Supervision
Number of supervisions
Current Supervision
Commenced | Level of Study | Research Title | Program | Supervisor Type |
---|---|---|---|---|
2023 | PhD | Targeting Mucosal Healing Pathways for the Prevention of Anastomotic Leaks. | PhD (Immunology & Microbiol), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2023 | PhD | Investigating The Gut - Lung Axis In Respiratory Infections In Inflammatory Bowel Disease | PhD (Immunology & Microbiol), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
Dr Huw McCarthy
Position
Postdoctoral Researcher
Gastrointestinal Research Group
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing
Contact Details
huw.mccarthy@newcastle.edu.au |
Office
Room | HMRI Level 3 East |
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Building | HMRI level 3 East |
Location | HMRI , |