Professor Hubert Hondermarck

Professor Hubert Hondermarck

Professor

School of Biomedical Sciences and Pharmacy (Medical Biochemistry)

Career Summary

Biography

Hubert Hondermarck obtained a PhD in neurobiochemistry at the University of Lille in France (1990) and was a post-doctoral researcher at the University of California in Irvine (1990-1993) where he investigated the molecular mechanisms of neuronal cell differentiation using proteomics. He founded a research unit of the French Institute of Health and Medical Research (U908 INSERM) dedicated to the study of growth factor signaling and functional proteomics in breast cancer. In 2011, he relocated to the University of Newcastle to start a new program on the function of neurotrophic growth factors and the impact of the nervous system in cancer initiation and progression.

Research Expertise: Cancer Neurobiology and Proteomics

Hubert Hondermarck research group works on the crosstalk between nerves and cancer cells, and its impact on tumour growth and metastasis. Until recently neurons were thought not to be involved in cancer. However, recent evidence in prostate and breast cancers, including from our laboratory, have shown that nerves actually promote tumour progression and that denervation can suppress both the development of the primary tumor and the outburst of metastases. The objective of this research is to identify the molecular mediators of the cross-talk between nerves and cancer cells that may constitute new and innovative biomarkers and therapeutic targets in oncology. Our methodologies include the analysis of human tumour samples, cell cultures,  proteomics and mass spectrometry analysis. We work in collaboration with neurobiologists, pathologists, clinicians and private companies to translate the results of our research into practical outcomes in oncology.

                    

Figure: Nerve-cancer cell crosstalk.Nerves infiltrate the tumor microenvironment and stimulate cancer cell growth and metastasis through the secretion of neurotransmitters (such as catecholamines, acetylcholine and neuropeptides) initiating signaling pathways for growth and invasion in cancer cells after binding to neurotransmitter receptors (NTRs). Conversely, nerve infiltration in the tumor is mediated through the liberation of neurotrophic growth factors (such as NGF) by cancer cells, resulting in neuron outgrowth (axonogenesis or neo-neurogenesis), as well as autocrine stimulation of cancer cells via the stimulation of corresponding receptor tyrosine kinases (RTKs). This reciprocal interaction fuels tumor development and also impacts the microenvironment, as the liberated neurotransmitters and growth factors can also act on endothelial and immune cells, then contributing to tumor inflammation and neo-angiogenesis. Cancer-induced pain can also be a consequence of tumor innervation. PLCγ, phospholipase C gamma; cAMP, cyclic adenosine monophosphate; STAT, signal transducer activator of transcription; PKC, protein kinase C; MAPK, mitogen-activated protein kinases. From our review Jobling et al. Cancer Res. (2015).

Scientific production

Hubert Hondermarck has published 91 PubMed referenced articles on cancer cell biology and proteomics http://www.ncbi.nlm.nih.gov/pubmed?term=hondermarck, and 2 internationally issued patents in collaboration with biopharmaceutical companies.

Most recent publications 

Boilly B, Faulkner S, Jobling P, Hondermarck H. Nerve dependence: from regeneration to cancer. Cancer Cell. 2017 31:342-354.

Faulkner S, Roselli S, Demont Y, Pundavela J, Choquet G, Leissner P, Oldmeadow C, Attia J, Walker MM, Hondermarck H.ProNGF is a potential diagnostic biomarker for thyroid cancer. Oncotarget. 2016 7:28488-97.

Shargh VH, Hondermarck H, Liang M. Albumin hybrid nanoparticles loaded with tyrosine kinase A inhibitor GNF-5837 for targeted inhibition of breast cancer cell growth and invasion. Int J Pharm. 2016 515:527-534.

Jobling P, Pundavela J, Oliverira SMR, Roselli S, Walker MM, Hondermarck H. Nerve-cancer cell crosstalk: a novel promoter of tumor progression. Cancer Res. 2015, 75, 1-5.

Pundavela J, Roselli S, Faulkner S, Attia J, Scott RJ, Thorne RF, Bradshaw RA, Walker MM, Jobling P, Hondermarck H. Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer. Molecular Oncol. 2015, 9(8):1626-35.

Dun MD, Chalkley RJ, Faulkner S, Keene S, Avery-Kiejda K, Scott RJ, Falkenby LG, Cairns MJ, Larsen MR, Bradshaw RA, Hondermarck
H. Proteotranscriptomic profiling of 231-BR breast cancer cells: identification of potential biomarkers and therapeutic targets for brain metastasis. Mol Cell Proteomics. 2015, 14(9):2316-30.

Roselli S, Pundavela J, Demont Y, Faulkner S, Sheridan K, AttiaJ, Jiang CC, Zhang XD, Walker MM, Hondermarck H. Sortilin is associated with breast cancer aggressiveness and contributes to tumour cell adhesion and invasion. Oncotarget 2015, 6(12):10473-86.

Faulkner, S., Dun, M.D., Hondermarck, H. Proteogenomics: emergence and promise. Cell Mol Life Sci. 2015, 72(:953-7.

Pundavela J, Demont Y, Jobling P, Lincz LF, Roselli S, Thorne RF, Bond D, Bradshaw RA, Walker MM, Hondermarck H. ProNGF correlates with Gleason score and is a potential driver of nerve infiltration in prostate cancer. Am J Pathol. 2014, 184, 3156-62.

Editorial boards

Hubert Hondermarck is a member of the Board of the following Journals: Molecular and Cellular Proteomics (ASBMB), Proteomics Clinical Applications (Wiley), Open Cancer Journal (Bentham) and Frontiers in Endocrinology (Frontiers Media).

Teaching Expertise

Biochemistry, proteomics, cancer biology, bioinformatics.

Course coordinator: HUBS3302 Bioinformatic and functional genomics. HUBS3409. Projects in Biomedical Sciences.

HUBS2209. Human Molecular Sciences.

Administrative Activities

Head of the Discipline of Medical Biochemistry (Faculty of Health and Medicine).


Qualifications

  • PhD (Life Sciences & Health), University of Lille - France

Keywords

  • Cancer biology
  • Cellular and molecular biology
  • Growth factors
  • Proteomics
  • Translational cancer research

Languages

  • French (Mother)

Fields of Research

Code Description Percentage
110106 Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics) 40
111201 Cancer Cell Biology 60

Professional Experience

UON Appointment

Title Organisation / Department
Professor University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
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Grants and Funding

Summary

Number of grants 23
Total funding $3,538,607

Click on a grant title below to expand the full details for that specific grant.


20171 grants / $200,000

Targeting Nerves as a New Therapeutic Strategy in Pancreatic Cancer$200,000

Funding body: Maitland Cancer Appeal Committee

Funding body Maitland Cancer Appeal Committee
Project Team Professor Hubert Hondermarck, Doctor Phil Jobling, Professor Marjorie Walker
Scheme Research Project
Role Lead
Funding Start 2017
Funding Finish 2019
GNo G1700836
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

20164 grants / $216,269

A systems biology capability for the Ramaciotti Centre for Genomics$75,592

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Associate Professor Stuart Cordwell, Associate Professor Steven Djordjevic, Professor Marc Wilkins, Professor Rick Cavicchioli, Professor Nicolle Packer, Professor Gilles Guillemin, Associate Professor Ann Goodchild, Laureate Professor Rodney Scott, Doctor Rick Thorne, Professor Hubert Hondermarck, Dr Dianne McDougald, Dr Garruy Myers, Professor David James, Professor Stephen Simpson, Professor Richard Payne
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2016
Funding Finish 2016
GNo G1600914
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

A systems biology capability for the Ramaciotti Centre for Genomics$72,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Stuart Cordwell, Professor David James, Professor Stephen Simpson, Professor Richard Payne, Professor Rick Cavicchioli, Professor Nicolle Packer, Professor Gilles Guillemin, Associate Professor Ann Goodchild, Laureate Professor Rodney Scott, Doctor Rick Thorne, Professor Hubert Hondermarck, Associate Professor Steven Djordjevic, Dr Dianne McDougald, Dr Garruy Myers
Scheme Equipment Grant
Role Investigator
Funding Start 2016
Funding Finish 2016
GNo G1500600
Type Of Funding Internal
Category INTE
UON Y

A novel biomarker and innovative therapeutic strategy for oesophageal cancer$48,677

Funding body: Hunter New England Local Health District

Funding body Hunter New England Local Health District
Project Team Professor Hubert Hondermarck, Professor Marjorie Walker, Doctor Vanessa Wills, Doctor Phil Jobling, Professor John Attia, Professor Robert Rush
Scheme Project Grant
Role Lead
Funding Start 2016
Funding Finish 2016
GNo G1601109
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Neurotrophins and their receptors as clinical biomarkers and therapeutic targets in prostate cancer.$20,000

Funding body: Hunter Cancer Research Alliance

Funding body Hunter Cancer Research Alliance
Project Team

Phil Jobling, Marjorie Walker, Martin Jarad, Christopher Oldmeadow, Robert Rush, Jay Pundavela, Sam Faulkner, Alison Rutledge, Sonia Rodriguez Oliveira

Scheme Pilot Project
Role Lead
Funding Start 2016
Funding Finish 2017
GNo
Type Of Funding Other Public Sector - Local
Category 2OPL
UON N

20155 grants / $1,211,250

High resolution fourier transform mass spectrometry platform for the discovery of novel cancer biomarkers and drug targets using label-free and isobaric-tagged approaches for quantitative proteomics.$500,000

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Professor Xu Dong Zhang, Doctor Matt Dun, Professor Jennifer Martin, Professor Hubert Hondermarck, Laureate Professor John Aitken, Doctor Nikki Verrills, Doctor Pradeep Tanwar, Laureate Professor Rodney Scott, Professor Maria Kavallaris, Dr Darren Saunders
Scheme Research Equipment Grant
Role Investigator
Funding Start 2015
Funding Finish 2016
GNo G1500599
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Advanced Technical Support for Oncology Single Cell Analysis Technologies$300,000

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Laureate Professor Rodney Scott, Professor Xu Dong Zhang, Professor Hubert Hondermarck, Conjoint Professor Stephen Ackland, Doctor Craig Gedye, Doctor Pradeep Tanwar, Doctor Chen Chen Jiang, Doctor Matt Dun, Professor Paul de Souza, Associate Professor Kevin Spring, Dr Tao Liu
Scheme Research Infrastructure Grants
Role Investigator
Funding Start 2015
Funding Finish 2018
GNo G1500824
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Inhibiting Trk tyrosine kinase receptors in cancer$200,000

Inhibiting Trk tyrosine kinase receptors in cancer

Funding body: Ignyta Inc. (San Diego, California)

Funding body Ignyta Inc. (San Diego, California)
Project Team

Hubert Hondermarck

Scheme Private
Role Lead
Funding Start 2015
Funding Finish 2015
GNo
Type Of Funding International - Non Competitive
Category 3IFB
UON N

High resolution fourier transform mass spectrometry platform for the discovery of novel cancer biomarkers and drug targets using label-free and isobaric-tagged approaches for quantitative proteomics.$196,250

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Xu Dong Zhang, Doctor Matt Dun, Professor Jennifer Martin, Professor Hubert Hondermarck, Laureate Professor John Aitken, Doctor Nikki Verrills, Doctor Pradeep Tanwar, Laureate Professor Rodney Scott, Professor Maria Kavallaris, Dr Darren Saunders
Scheme Equipment Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1500935
Type Of Funding Internal
Category INTE
UON Y

Nerves and Neurotrophins as New Therapeutic Targets in Cervical Cancer$15,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Hubert Hondermarck, Doctor Phil Jobling, Professor Marjorie Walker, Ms Janine Lombard, Doctor Jay Pundavela
Scheme Project Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1501579
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20144 grants / $499,487

High Throughput Image Capture Platform for Translational Cancer Research$282,614

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Conjoint Professor Stephen Ackland, Laureate Professor Rodney Scott, Professor John Forbes, Professor Xu Dong Zhang, Professor Marjorie Walker, Professor Hubert Hondermarck, Doctor Craig Gedye, Doctor Rick Thorne, Mr Loui Rassam, Doctor Stephen Braye
Scheme Research Equipment Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1400626
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Visualisation of microparticles for development of biomarkers and targeted drug delivery mechanisms$125,199

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Associate Professor Christopher Scarlett, Doctor Kathryn Skelding, Doctor Jude Weidenhofer, Doctor Matt Dun, Doctor Kelly Kiejda, Professor Adam McCluskey, Ms Elham Sadeqzadeh, Professor Hubert Hondermarck, Doctor Rick Thorne, Laureate Professor Rodney Scott
Scheme Research Equipment Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1400627
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

JuLI Stage $71,674

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Pradeep Tanwar, Professor Eileen McLaughlin, Professor Robin Callister, Professor Xu Dong Zhang, Professor Murray Cairns, Professor Brett Nixon, Professor Hubert Hondermarck, Associate Professor Phillip Dickson, Doctor Nikki Verrills, Doctor Matt Dun, Doctor Jessie Sutherland, Doctor Janani Kumar, Doctor Jay Horvat, Doctor Susan Hua, Associate Professor Liz Milward, Associate Professor Estelle Sontag, Professor Dirk Van Helden, Doctor Janet Bristow, Doctor Jean-Marie Sontag
Scheme Equipment Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1500860
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Prostate Cancer: A new protein for improving diagnosis, prognosis and treatment$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Severine Roselli, Professor Hubert Hondermarck
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1401520
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20134 grants / $361,096

Triple Quadrupole Mass Spectrometer with nano-infusion for targeted protein quantification$300,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Mark Baker, Laureate Professor John Aitken, Conjoint Professor Bogdan Dlugogorski, Professor Hubert Hondermarck
Scheme Equipment Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1200137
Type Of Funding Internal
Category INTE
UON Y

12th World Congress of the Human Proteome Organization (HUPO), Yokohama Japan, 14 - 18 September 2013$1,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Professor Hubert Hondermarck
Scheme Travel Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300864
Type Of Funding Internal
Category INTE
UON Y

20124 grants / $494,694

High-Resolution Isoelectric Phosphoprotein Signalling System for Signalling Research, Biomarker Validation and Drug Development – Equipment Grant$143,394

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Rick Thorne, Professor Xu Dong Zhang, Professor Hubert Hondermarck, Conjoint Professor Stephen Ackland, Doctor Lisa Lincz, Doctor Jennette Sakoff, Emeritus Professor Leonie Ashman
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200555
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Microscopic illumination system for advanced fluorescent protein technology$34,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Rick Thorne, Professor Xu Dong Zhang, Professor Murray Cairns, Doctor Nikki Verrills, Doctor Charles De Bock, Doctor Jude Weidenhofer, Doctor Severine Roselli, Doctor Kathryn Skelding, Emeritus Professor Leonie Ashman, Professor Hubert Hondermarck
Scheme Equipment Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100983
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Does Ubiquitination control the altered expression of tetraspanin proteins in Breast Cancer?$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jude Weidenhofer, Emeritus Professor Leonie Ashman, Professor Hubert Hondermarck
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200169
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20111 grants / $555,811

Priority Research Centre for Cancer$555,811

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Stephen Ackland, Professor Xu Dong Zhang, Professor John Forbes, Emeritus Professor Leonie Ashman, Doctor Nikola Bowden, Professor Gordon Burns, Conjoint Professor Jim Denham, Professor Hubert Hondermarck, Doctor Lisa Lincz, Doctor Jennette Sakoff, Associate Professor Peter Stanwell, Doctor Rick Thorne, Doctor Nikki Verrills
Scheme Priority Research Centre
Role Investigator
Funding Start 2011
Funding Finish 2016
GNo G1101013
Type Of Funding Internal
Category INTE
UON Y
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Research Supervision

Number of supervisions

Completed4
Current14

Total current UON EFTSL

PhD3.75

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2017 PhD Neuro-Cancer Crosstalk in Pancreatic Cancer PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle Principal Supervisor
2017 PhD Comparison of Histone Post-translational Modifications in Sperm Cells of Infertile and Fertile Men by Mass Spectrometry. PhD (Biological Sciences), Faculty of Science, The University of Newcastle Co-Supervisor
2017 PhD Nerve Infiltration and its Impact in Breast and Prostate Cancer PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle Principal Supervisor
2017 PhD A Novel Biomarker and Innovative Therapeutic Strategy for Oesophageal Cancer PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle Principal Supervisor
2017 PhD Nerve Dependence in Human Cancers PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Principal Supervisor
2015 PhD The Role of mTOR Hyperactivation in the Pathogenesis of PCOS PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2015 PhD Early serous ovarian carcinogenesis : Understanding the genetic and lifestyle factors PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2015 PhD Genesis of ovarian cancer: understanding the mechanisms of oviductal epithelial cell homoeostasis PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2015 PhD Targeting Thyroid Cancer Cells for Diagnosis and Treatment PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2014 PhD ProNGF and its Receptors in Pancreatic Cancer and Melanoma PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle Principal Supervisor
2014 PhD The Nerve-Cancer Connection in Ovarian Cancer PhD (Human Physiology), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2014 PhD Role of mTOR signalling in Ovarian Cancer PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2014 PhD To Study the Female Lower Reproductive Tract Cell Dynamics, Homeostasis and Cancer PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2013 PhD Role of WNT Signalling in Endometrial Homeostasis and Cancer PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2017 PhD Multifunctional Nanomedicines Based on Albumin for Targeted Breast Cancer Therapy PhD (Pharmacy), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2017 PhD Wnt Signalling in Germ Cells and Reproductive Tract Development PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2015 PhD Role of FAT1 Cadherin in Neuronal Differentiation PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2015 PhD ProNGF/NGF and Nerve Infiltration in Prostate and Breast Cancer PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle Principal Supervisor
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News

Hubert Hondermarck

Study strikes a nerve with the spread of cancer

March 27, 2017

A group led by University of Newcastle biochemistry researcher Hubert Hondermarck has found parallels between tissue regeneration, nerve growth and tumour development, confirming for the first time that the nervous system is strongly implicated in the onset and spread of cancer.

John Forbes

International spotlight on cancer research

October 23, 2013

Four of North America's leading cancer researchers will give keynote presentations at the international Translational Cancer Research Conference in Newcastle from tomorrow until Friday.

Professor Hubert Hondermarck

Position

Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Medical Biochemistry

Contact Details

Email hubert.hondermarck@newcastle.edu.au
Phone (02) 4921 8830
Fax (02) 4921 7903

Office

Room LS3-35
Building Life Sciences
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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