Dr Daniel Tan

Dr Daniel Tan

Postdoctoral Researcher

School of Biomedical Sciences and Pharmacy

Career Summary

Biography

Dr Daniel Tan obtained his PhD in Pharmacology in 2018 from the National University of Singapore under the supervision of Professor Fred Wong. He has had experience in modeling various respiratory diseases such as asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis in mice whilst developing novel therapies from natural products. He has an interest in the immunomodulatory and antioxidative potential of drugs for the treatment of acute lung infections, chronic inflammatory lung diseases and exacerbations. He is now working under Laureate Professor Paul Foster and Dr Hock Tay to unravel the mechanisms underpinning the pathophysiology of severe asthma. Dr Daniel Tan is a also young investigator member of the immunopharmacology section of the International Union of Basic and Clinical Pharmacology.

Qualifications

  • Doctor of Philosophy, National University of Singapore

Keywords

  • Asthma
  • COPD
  • Immunology
  • Natural Product
  • Pharmacology

Languages

  • English (Mother)
  • Mandarin (Fluent)

Fields of Research

Code Description Percentage
320103 Respiratory diseases 50
320404 Cellular immunology 50

Professional Experience

UON Appointment

Title Organisation / Department
Postdoctoral Researcher University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

Dates Title Organisation / Department
1/5/2018 - 31/5/2020 Research Fellow

  • Development of novel therapy for experimental IPF in mice
  • Development of novel therapy for experimental asthma in mice
  • Drug development and optimization programme (DDOP)
  • Mentoring students

National University of Singapore
Department of Pharmacology
Singapore

Professional appointment

Dates Title Organisation / Department
1/5/2019 -  Young Investigator

To encourage the organization of international cooperation in immunopharmacology

The International Union of Basic and Clinical Pharmacology (IUPHAR)
Immunopharmacology
United Kingdom

Teaching appointment

Dates Title Organisation / Department
1/8/2018 - 31/5/2020 Lecturer

 LSM3211 Fundamental Pharmacology

National University of Singapore
Department of Pharmacology
Singapore
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (24 outputs)

Year Citation Altmetrics Link
2021 Tran QTN, Tan WSD, Wong WSF, Chai CLL, 'Polypharmacology of andrographolide: beyond one molecule one target', NATURAL PRODUCT REPORTS, 38 682-692 (2021)
DOI 10.1039/d0np00049c
Citations Scopus - 4Web of Science - 4
2020 Liao W, Lim AYH, Tan WSD, Abisheganaden J, Wong WSF, 'Restoration of HDAC2 and Nrf2 by andrographolide overcomes corticosteroid resistance in chronic obstructive pulmonary disease', BRITISH JOURNAL OF PHARMACOLOGY, 177 3662-3673 (2020)
DOI 10.1111/bph.15080
Citations Scopus - 5Web of Science - 6
2020 Cheong DHJ, Tan DWS, Wong FWS, Thai T, 'Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases', PHARMACOLOGICAL RESEARCH, 158 (2020)
DOI 10.1016/j.phrs.2020.104901
Citations Scopus - 33Web of Science - 31
2020 Tran QTN, Tan DWS, Wong WSF, Chai CLL, 'From irreversible to reversible covalent inhibitors: Harnessing the andrographolide scaffold for anti-inflammatory action', EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 204 (2020)
DOI 10.1016/j.ejmech.2020.112481
Citations Scopus - 3Web of Science - 5
2020 Mei D, Tan WSD, Tay Y, Mukhopadhyay A, Wong WSF, 'Therapeutic RNA Strategies for Chronic Obstructive Pulmonary Disease', TRENDS IN PHARMACOLOGICAL SCIENCES, 41 475-486 (2020)
DOI 10.1016/j.tips.2020.04.007
Citations Scopus - 8Web of Science - 7
2020 Tavares LP, Peh HY, Tan WSD, Pahima H, Maffia P, Tiligada E, Levi-Schaffer F, 'Granulocyte-targeted therapies for airway diseases', PHARMACOLOGICAL RESEARCH, 157 (2020)
DOI 10.1016/j.phrs.2020.104881
Citations Scopus - 4Web of Science - 5
2020 Mei D, Tan WSD, Liao W, Heng CKM, Wong WSF, 'Activation of angiotensin II type-2 receptor protects against cigarette smoke-induced COPD', Pharmacological Research, 161 (2020)

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally. Cumulative evidence has implicated renin-angiotensin system (RAS) in the pathogenesis of... [more]

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally. Cumulative evidence has implicated renin-angiotensin system (RAS) in the pathogenesis of COPD. This study aimed to investigate potential protective effects of angiotensin II type-2 receptor (AT2R) activation in cigarette smoke (CS)-induced COPD models. Compound 21 (C21), a selective and potent non-peptide small molecule AT2R agonist, was evaluated for anti-inflammatory, anti-oxidative and anti-remodeling activities in a two-week (acute) and an eight-week (chronic) CS-induced COPD models. C21 inhibited CS-induced increases in macrophage and neutrophil counts, pro-inflammatory cytokines and oxidative damage markers in bronchoalveolar lavage (BAL) fluid, and TGF-ß1 in lung tissues, from COPD models. C21 restored phosphatase activities and reduced phospho-p38 MAPK, phospho-ERK and p65 subunit of NF-¿B levels in CS-exposed lung tissues. C21 also suppressed CS-induced increases in a-Sma, Mmp9, Mmp12 and hydroxyproline levels in lung tissues, and neutrophil elastase activity in BAL fluid. C21 modulated RAS in CS-exposed lungs by downregulating Ang II but upregulating Ang-(1¿7) and Mas receptor levels. C21 prevented CS-induced emphysema and improved lung functions in chronic COPD model. We report here for the first time the protective effects of AT2R agonist C21 against CS-induced COPD, and provide strong evidence for further development of AT2R agonist for the treatment of COPD.

DOI 10.1016/j.phrs.2020.105223
Citations Scopus - 1
2020 Herr DR, Yam TYA, Tan WSD, Koh SS, Wong WSF, Ong W-Y, Chayaburakul K, 'Ultrastructural Characteristics of DHA-Induced Pyroptosis', NEUROMOLECULAR MEDICINE, 22 293-303 (2020)
DOI 10.1007/s12017-019-08586-y
Citations Scopus - 7Web of Science - 7
2019 Tan WSD, Shen H-M, Wong WSF, 'Dysregulated autophagy in COPD: A pathogenic process to be deciphered', PHARMACOLOGICAL RESEARCH, 144 1-7 (2019)
DOI 10.1016/j.phrs.2019.04.005
Citations Scopus - 12Web of Science - 12
2019 Mei D, Tan WSD, Wong WSF, 'Pharmacological strategies to regain steroid sensitivity in severe asthma and COPD', CURRENT OPINION IN PHARMACOLOGY, 46 73-81 (2019)
DOI 10.1016/j.coph.2019.04.010
Citations Scopus - 18Web of Science - 19
2018 Tan WSD, Liao W, Peh HY, Vila M, Dong J, Shen H-M, Wong WSF, 'Andrographolide simultaneously augments Nrf2 antioxidant defense and facilitates autophagic flux blockade in cigarette smoke-exposed human bronchial epithelial cells', TOXICOLOGY AND APPLIED PHARMACOLOGY, 360 120-130 (2018)
DOI 10.1016/j.taap.2018.10.005
Citations Scopus - 20Web of Science - 21
2018 Tan WSD, Liao W, Zhou S, Mei D, Wong W-SF, 'Targeting the renin-angiotensin system as novel therapeutic strategy for pulmonary diseases', CURRENT OPINION IN PHARMACOLOGY, 40 9-17 (2018)
DOI 10.1016/j.coph.2017.12.002
Citations Scopus - 84Web of Science - 80
2018 Dong J, Liao W, Peh HY, Tan WSD, Zhou S, Wong WSF, 'Ribosomal Protein S3 Gene Silencing Protects Against Cigarette Smoke-Induced Acute Lung Injury', MOLECULAR THERAPY-NUCLEIC ACIDS, 12 370-380 (2018)
DOI 10.1016/j.omtn.2018.05.027
Citations Scopus - 8Web of Science - 8
2017 Peh HY, Tan WSD, Chan TK, Pow CW, Foster PS, Wong WSF, 'Vitamin E isoform -tocotrienol protects against emphysema in cigarette smoke-induced COPD', Free Radical Biology and Medicine, 110 332-344 (2017) [C1]

Inflammation and oxidative stress contribute to emphysema in COPD. Although corticosteroids are the standard of care for COPD, they do not reduce oxidative stress, and a subset of... [more]

Inflammation and oxidative stress contribute to emphysema in COPD. Although corticosteroids are the standard of care for COPD, they do not reduce oxidative stress, and a subset of patients is steroid-resistant. Vitamin E isoform ¿-tocotrienol possesses both anti-inflammatory and anti-oxidative properties that may protect against emphysema. We aimed to establish the therapeutic potential of ¿-tocotrienol in cigarette smoke-induced COPD models in comparison with prednisolone. BALB/c mice were exposed to cigarette smoke for 2 weeks or 2 months. ¿-Tocotrienol and prednisolone were given orally. Bronchoalveolar lavage (BAL) fluid and lung tissues were assessed for inflammation, oxidative damage, and regulation of transcription factor activities. Emphysema and lung function were also evaluated. ¿-Tocotrienol dose-dependently reduced cigarette smoke-induced BAL fluid neutrophil counts and levels of cytokines, chemokines and oxidative damage biomarkers, and pulmonary pro-inflammatory and pro-oxidant gene expression, but restored lung endogenous antioxidant activities. ¿-Tocotrienol acted by inhibiting nuclear translocation of STAT3 and NF-¿B, and up-regulating Nrf2 activation in the lungs. In mice exposed to 2-month cigarette smoke, ¿-tocotrienol ameliorated bronchial epithelium thickening and destruction of alveolar sacs in lungs, and improved lung functions. In comparison with prednisolone, ¿-tocotrienol demonstrated better anti-oxidative efficacy, and protection against emphysema and lung function in COPD. We revealed for the first time the anti-inflammatory and antioxidant efficacies of ¿-tocotrienol in cigarette smoke-induced COPD models. In addition, ¿-tocotrienol was able to attenuate emphysematous lesions and improve lung function in COPD. ¿-Tocotrienol may have therapeutic potential for the treatment of COPD.

DOI 10.1016/j.freeradbiomed.2017.06.023
Citations Scopus - 10Web of Science - 12
Co-authors Paul Foster
2017 Tan WSD, Liao W, Zhou S, Wong WSF, 'Is there a future for andrographolide to be an anti-inflammatory drug? Deciphering its major mechanisms of action', BIOCHEMICAL PHARMACOLOGY, 139 71-81 (2017)
DOI 10.1016/j.bcp.2017.03.024
Citations Scopus - 80Web of Science - 76
2017 Dong J, Liao W, Peh HY, Chan TK, Tan WSD, Li L, et al., 'Ribosomal protein S3 gene silencing protects against experimental allergic asthma', BRITISH JOURNAL OF PHARMACOLOGY, 174 540-552 (2017)
DOI 10.1111/bph.13717
Citations Scopus - 3Web of Science - 3
2017 Chan TK, Tan WSD, Peh HY, Wong WSF, 'Aeroallergens Induce Reactive Oxygen Species Production and DNA Damage and Dampen Antioxidant Responses in Bronchial Epithelial Cells', JOURNAL OF IMMUNOLOGY, 199 39-47 (2017)
DOI 10.4049/jimmunol.1600657
Citations Scopus - 22Web of Science - 21
2016 Liao W, Tan WSD, Wong WSF, 'Andrographolide Restores Steroid Sensitivity To Block Lipopolysaccharide/IFN-gamma-Induced IL-27 and Airway Hyperresponsiveness in Mice', JOURNAL OF IMMUNOLOGY, 196 4706-4712 (2016)
DOI 10.4049/jimmunol.1502114
Citations Scopus - 23Web of Science - 19
2016 Chan TK, Loh XY, Peh HY, Tan WNF, Tan WSD, Li N, et al., 'House dust mite-induced asthma causes oxidative damage and DNA double-strand breaks in the lungs', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 138 84-+ (2016)
DOI 10.1016/j.jaci.2016.02.017
Citations Scopus - 74Web of Science - 74
2016 Tang WSD, Peh HY, Liao W, Pang CH, Chan TK, Lau SH, et al., 'Cigarette Smoke-Induced Lung Disease Predisposes to More Severe Infection with Nontypeable Haemophilus influenzae: Protective Effects of Andrographolide', JOURNAL OF NATURAL PRODUCTS, 79 1308-1315 (2016)
DOI 10.1021/acs.jnatprod.5b01006
Citations Scopus - 22Web of Science - 21
2016 Peh HY, Tan WSD, Liao W, Wong WSF, 'Vitamin E therapy beyond cancer: Tocopherol versus tocotrienol', PHARMACOLOGY & THERAPEUTICS, 162 152-169 (2016)
DOI 10.1016/j.pharmthera.2015.12.003
Citations Scopus - 137Web of Science - 125
2015 Tan WSD, Wong JL, Tie ST, Abisheganaden JA, Lim AYH, Wong WSF, 'ß2-Adrenoceptor in Obstructive Airway Diseases: Agonism, Antagonism or Both? 199-206 (2015)
DOI 10.5320/wjr.v5.i3.199
2014 Ng DSW, Liao W, Tan WSD, Chan TK, Loh XY, Wong WSF, 'Anti-malarial drug artesunate protects against cigarette smoke-induced lung injury in mice', PHYTOMEDICINE, 21 1638-1644 (2014)
DOI 10.1016/j.phymed.2014.07.018
Citations Scopus - 28Web of Science - 27
2012 Tan WSD, Lee JJ, Satish RL, Ang E-T, 'Detectability of secretagogin in human erythrocytes', NEUROSCIENCE LETTERS, 526 59-62 (2012)
DOI 10.1016/j.neulet.2012.08.006
Citations Scopus - 2Web of Science - 2
Show 21 more journal articles

Conference (1 outputs)

Year Citation Altmetrics Link
2017 Wong WSF, Tan WSD, Chan TK, Foster PS, Peh HY, 'VITAMIN E ISOFORM GAMMA-TOCOTRIENOL PROTECTS AGAINST EMPHYSEMA DEVELOPMENT IN CIGARETTE SMOKE-INDUCED CHRONIC OBSTRUCTIVE PULMONARY DISEASE', RESPIROLOGY (2017)
Co-authors Paul Foster
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Dr Daniel Tan

Position

Postdoctoral Researcher
Hock Tay/Paul Foster
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing

Contact Details

Email daniel.tan@newcastle.edu.au
Phone 62812
Links Research Networks
Research Networks
Research Networks

Office

Room HMRI 2409
Building HMRI Building
Location HMRI Building Level 2

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