Staff Profile

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Career Summary

Biography

I completed my undergraduate training at Imperial College, University of London including an intercalated BSc, with a period of research at Washington University, St Louis, USA. Towards the end of my undergraduate training I joined the Royal Navy, completing house officer jobs in Portsmouth and Plymouth followed by military training at Britannia Royal Naval College, Dartmouth. I was then appointed as medical officer to HMS Norfolk on deployment to the Caribbean. On my return I worked as a medical officer at the Institute of Naval Medicine specialising in diving medicine and around this time was awarded the Diploma in the Medical Care of Catastrophes, a qualification in remote and refugee medicine. I then deployed to sea again, this time on HMS Endurance spending a season in Antarctica supporting a scientific programme on the continent.

My Senior House Officer training was at Derriford Hospital in Plymouth, one of the largest district general hospitals in Europe, where I obtained membership of the Royal College of Physicians. I was then deployed to Southern Iraq as one of two physicians in the British military hospital, Shaibah and on my return worked at the Royal Brompton Hospital, London.

My Specialist training in Respiratory, Sleep and General (internal) Medicine started in Wales, then, following a competitive grant award, I moved to the University of Southampton to work with Professor Stephen Holgate’s group. I was awarded my PhD in 2011, the research leading to several International presentations and peer reviewed articles, including a first author paper published in the New England Journal of Medicine examining the effect of repeated bronchoconstriction on the airways in asthma. I also worked with the Defence Science and Technology Laboratories at Porton Down to examine causes and effects of acute lung injury, work which lead to the award of the Gilbert Blane medal by the Presidents of both the Royal College of Physicians and the Royal College of Surgeons.

I was then appointed as a Consultant physician in Respiratory, Sleep and General (Internal) Medicine at the University Hospital, Southampton and Senior Lecturer in Medicine at the University of Southampton. I have received grants from the British Lung Foundation, the Southampton Marine and Maritime Institute, the Institute for Life Sciences and the Gerald Kerkut Foundation to continue research into the effect of physical and environmental stress on lung disease.

I have recently been appointed as a Staff Specialist in Respiratory and General Medicine at the John Hunter Hospital, and a conjoint Associate Professor at the University of Newcastle. I hope to pursue my clinical interests in difficult asthma and interstitial lung disease, and also to continue my research into physical airway stress and fibrotic responses in the airway in collaboration with the team at the HMRI.

Research

Research keywords

  • allergy
  • asthma
  • bronchoconstriction
  • interstitial lung disease
  • respiratory

Research expertise

Role of mechanical forces in the pathophysiology of asthma

Dr Grainge recently demonstrated that mechanical forces may play an important role in determining long term changes in human airways, that research was published in the New England Journal of Medicine in 2011. Following his move to the University of Newcastle he and his team are investigating how the mechanical forces that are associated with airway narrowing in asthma influence the airway.

The role of environmental dusts in pathogenesis of lung disease

Recent clinical evidence has suggested that some individuals exposed to high levels of inhaled dusts develop the usually rare lung disease, constrictive bronchiolitis. Following the award of over £220,000 from the British Lung Foundation, the Institute of Life Sciences and the Southampton Marine and Maritime Institution Dr Grainge and his team are investigating the mechanisms underling the development of lung disease including constrictive bronchiolitis following environmental exposure to inhaled particles, and are attempting to identify potential therapies. This project is a collaboration between the National Oceanography Centre and the University of Southampton Faculty of Medicine.

The effect of platelet antagonists on allergen challenge in asthma

Platelet activation in the lungs occurs following many stimuli including allergen challenge and chemical injury to the lung. Dr Grainge and his group hypothesise that inhibiting platelet activation will decrease the lung injury associated with these stimuli and may provide an additional therapeutic pathway for asthma which has yet to be investigated. The project involves a double blind randomized controlled trial of Clopidogrel, an oral platelet antagonist, and its effects on inhaled allergen challenge.

Languages

  • English

Fields of Research

CodeDescriptionPercentage
110203Respiratory Diseases100

Memberships

Editorial Board.

  • Editor - Respirology Case Reports

Awards

Recognition.

2013Leatherdale Prize for Clinical Teaching: Finalist
University of Southampton (United Kingdom)
Finalist, Leatherdale Prize for Clinical Teaching. This award is given to the best clinical teacher on the undergraduate medical course.
2011Military and Civilian Health Partnership Awards. Winner in the
Military and Civilian Health Partnership Awards. Winner in the (United Kingdom)
Military and Civilian Health Partnership Awards. Winner in the Education & Training category. This award recognises outstanding education and training of military or civilian health providers. Awarded for providing training in emergency responses to chemical, biological and radiological incidents.
2011University of Southampton Translational Medicine Research Prize
University of Southampton (United Kingdom)
University of Southampton Translational Medicine Research Prize Awarded for performing and presenting the best translational medical research in the preceding year.

Research Award.

2014Michael Arthur Clinical Research Prize
University of Southampton (United Kingdom)
Michael Arthur Clinical Research Prize. Awarded by the Faculty of Medicine, University of Southampton for the highest quality of published original research in the preceding year.
2011British Lung Foundation Travel Fellowship
British Lung Foundation (United Kingdom)
British Lung Foundation Travel Fellowship
2010Gilbert Blane Medal
Royal College of Surgeons and Royal College of Physicians (United Kingdom)
Gilbert Blane Medal. This prize is awarded, only if warranted, annually to the Royal Navy Medical Officer who contributed most to the health of the members of the Royal Navy in that year. Awarded since 1830 and conferred by the Presidents of the Royal College of Physicians, and the Royal College of Surgeons
2010Colt Foundation Prize: Finalist
ROyal Society of Medicine (United Kingdom)
Finalist, Royal Society of Medicine Colt Foundation Prize. Work based on in vitro modelling of the effects of inhaled chemicals on the respiratory epithelium enabling rapid screening of potential therapies.
2009Asthma UK Travel Fellowship
Asthma UK Travel Fellowship (United Kingdom)
Asthma UK Travel Fellowship

Collaboration

I continue to collaborate extensively with the Respiratory Research group at the University of Southampton with work examining the nature and treatment possibilities for severe asthma. In addition I am collaborating with the Asthma and COPD Research Group at the University of Groningen in the Netherlands looking at the mechanical forces within the airway and how these impact on both acute and long term changes in the lungs of patients with airways disease. I am also collaborating with the Microbiome group at the South Australia Medical Research Insitute, examining the differences in the airway microbiome that occur in health and disease.

Teaching

Teaching keywords

  • general medicine
  • physiology
  • respiratory

Teaching expertise

Teaching Responsibilities

Delivers lectures and small group teaching on a variety of general medicine and respiratory medicine topics including respiratory physiology and pathophysiology. Provides clinical teaching on the wards and in clinic to medical students at various points in their undergraduate training.

IMPACT. Was one of the first instructors on the Ill Medical Patient Acute Care and Treatment (IMPACT) courses which are run for doctors in their first few years of postgraduate training. Continues to teach and direct the courses at various centers around the country.

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Highlighted Publications

For publications that are currently unpublished or in-press, details are shown in italics.

YearCitationAltmetricsLink
2011Grainge CL, Lau LCK, Ward JA, Dulay V, Lahiff G, Wilson S, et al., 'Effect of Bronchoconstriction on Airway Remodeling in Asthma', NEW ENGLAND JOURNAL OF MEDICINE, 364 2006-2015 (2011) [C1]

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (17 outputs)

YearCitationAltmetricsLink
2014Green BJ, Wiriyachaiporn S, Grainge C, Rogers GB, Kehagia V, Lau L, et al., 'Potentially Pathogenic Airway Bacteria and Neutrophilic Inflammation in Treatment Resistant Severe Asthma', PLOS ONE, 9 (2014) [C1]
2014Grainge C, Dennison P, Lau L, Davies D, Howarth P, 'Asthmatic and Normal Respiratory Epithelial Cells Respond Differently to Mechanical Apical Stress', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 190 477-480 (2014) [C1]
2013Grainge C, Jayasekera N, Dennison P, Rupani H, Kurukulaaratchy R, Howarth P, 'Case series reporting the effectiveness of mycophenolate mofetil in treatment-resistant asthma', EUROPEAN RESPIRATORY JOURNAL, 42 1134-1137 (2013) [C1]
2013Grainge CL, Davies DE, 'Epithelial Injury and Repair in Airways Diseases', CHEST, 144 1906-1912 (2013) [C1]
2013Grainge C, Jayasekera N, Dennison P, Rupani H, Kurukulaaratchy R, Howarth P, 'MYCOPHENOLATE MOFETIL IMPROVES LUNG FUNCTION AND SYMPTOMS IN SEVERE TREATMENT RESISTANT ASTHMA', RESPIROLOGY, 18 12-12 (2013) [E3]
2012Grainge C, Dulay V, Ward J, Sammut D, Davies E, Green B, et al., 'Resistin-like molecule-beta is induced following bronchoconstriction of asthmatic airways', RESPIROLOGY, 17 1094-1100 (2012) [C1]
2012Grainge C, Dragolea N, Howarth PH, 'ALLERGEN CHALLENGE INCREASES ALTERNATIVELY ACTIVATED MACROPHAGES WITHIN THE AIRWAYS IN ALLERGIC ASTHMA', RESPIROLOGY, 17 51-51 (2012) [E3]
2012Grainge C, Dulay V, Ward J, Lau L, Cottey L, Haitchi HM, et al., 'RESISTIN-LIKE MOLECULE BETA IN BRONCHIAL EPITHELIUM INCREASES WITH ASTHMA SEVERITY AND AIRWAY CHALLENGES', RESPIROLOGY, 17 26-26 (2012) [E3]
2012Grainge C, Dennison P, Davies DE, Howarth PH, 'COMPRESSION STIMULATES TGF beta 2 RELEASE FROM ASTHMATIC BUT NOT NORMAL PRIMARY BRONCHIAL EPITHELIAL CELLS', RESPIROLOGY, 17 42-42 (2012) [E3]
2011Grainge CL, Lau LCK, Ward JA, Dulay V, Lahiff G, Wilson S, et al., 'Effect of Bronchoconstriction on Airway Remodeling in Asthma', NEW ENGLAND JOURNAL OF MEDICINE, 364 2006-2015 (2011) [C1]
2011Grainge C, Howarth PH, 'Repeated high-dose inhalation allergen challenge in asthma', CLINICAL RESPIRATORY JOURNAL, 5 150-155 (2011) [C1]
2011Cakebread JA, Xu Y, Grainge C, Kehagia V, Howarth PH, Holgate ST, Davies DE, 'Exogenous IFN-beta has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127 1148-U416 (2011) [C1]
2011Grainge CL, Howarth PH, 'Bronchoconstriction and Airway Remodeling REPLY', NEW ENGLAND JOURNAL OF MEDICINE, 365 1157-1157 (2011)
2011Grainge CL, Howarth PH, 'The authors reply', New England Journal of Medicine, 365 1157-1157 (2011)
2010Grainge C, Rice P, 'Management of phosgene-induced acute lung injury', Clinical Toxicology, 48 497-508 (2010) [D1]
2010Grainge C, Jugg BJ, Smith AJ, Brown RFR, Jenner J, Parkhouse DA, Rice P, 'Delayed low-dose supplemental oxygen improves survival following phosgene-induced acute lung injury', Inhalation Toxicology, 22 552-560 (2010)
2010Hatzivlassiou M, Grainge C, Kehagia V, Lau L, Howarth PH, 'The allergen specificity of the late asthmatic reaction', ALLERGY, 65 355-358 (2010)
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Conference (1 outputs)

YearCitationAltmetricsLink
2010Cottey L, Jayasekera N, Haitchi H-M, Green B, Grainge C, Howarth P, 'AIRWAY EPITHELIAL TOLL RECEPTOR EXPRESSION IN ASTHMA AND ITS RELATIONSHIP TO DISEASE SEVERITY', THORAX, Westminster, ENGLAND (2010)
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Grants and Funding

Summary

Number of grants9
Total funding$1,385,096

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (3 grants)

Role of mechanical forces in asthma disease progression$210,474
Funding Body: Respiratory Medicine Charitable Trust John Hunter Hospital

SchemeRole
Respiratory Medicine CHaritable Trust John Hunter HospitalChief Investigator
Total AmountFunding StartFunding Finish
$210,47420142017
GNo:185315710

Investigation of the role of mechanical forces in respiratory disease$180,000
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Conjoint Associate Professor Christopher Grainge
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$180,00020142016
GNo:G1401248

Do asthma attacks worsen asthma in the long term?$22,500
Funding Body: Hunter Medical Research Institute

Project Team
Conjoint Associate Professor Christopher Grainge, Professor Darryl Knight
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$22,50020142014
GNo:G1401402

2013 (1 grants)

The role of environmental dust from the Middle East in the pathogenesis of constrictive bronchiolitis$198,000
Funding Body: British Lung Foundation and the Insitute for Life Sciences, Southampton

SchemeRole
British Lung Foundation and the Insitute for Life Sciences, SouthamptonChief Investigator
Total AmountFunding StartFunding Finish
$198,00020132016
GNo:185175720

2012 (1 grants)

The effect of clopidogrel on allergen-induced airway inflammation in asthma.$36,900
Funding Body: Asthma, Allergy and Inflammation Research Charity

SchemeRole
Asthma, Allergy and Inflammation Research CharityChief Investigator
Total AmountFunding StartFunding Finish
$36,90020122014
GNo:185175728

2011 (1 grants)

Role of mechanical forces in the pathophysiology of asthma.$198,000
Funding Body: Gerald Kerkut Trust and Southampton University Doctoral Training Award

SchemeRole
Gerald Kerkut Trust and Southampton University Doctoral Training AwardChief Investigator
Total AmountFunding StartFunding Finish
$198,00020112015
GNo:185175712

2009 (1 grants)

A novel approach to rapidly screen commercial off the shelf therapies for acute lung injury$27,000
Funding Body: Defence Science and Technology Laboratories

SchemeRole
Defence Science and Technology LaboratoriesChief Investigator
Total AmountFunding StartFunding Finish
$27,00020092009
GNo:185175704

2007 (1 grants)

Airway permeability and reactivity in acute lung injury and allergic asthma$487,000
Funding Body: Defence Postgraduate Medical Deanery

SchemeRole
Defence Postgraduate Medical DeaneryChief Investigator
Total AmountFunding StartFunding Finish
$487,00020072010
GNo:185175696

(1 grants)

Do viral infection and bronchoconstriction interact during exacerbation of asthma prolonging viral infection and worsening disease in the long term?$25,222
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Conjoint Associate Professor Christopher Grainge, Professor Darryl Knight
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$25,222
GNo:G1500546
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Research Supervision

Number of current supervisions3

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20132014Masters Medical Science
University of Southampton
Co-SupervisorNon invasive measures of asthma severity
20132016PHD Biological Sciences
University of Southampton
Principal SupervisorThe role of environmental dusts in the pathogenesis of lung disease
20122016PHD Medical Science
University of Southampton
Co-SupervisorEpithelial fibroblast interaction during respiratory virus infection

Past Supervision

YearProgramSupervisor TypeResearch Title
2011Honours Biological Sciences
University of Southampton
Co-SupervisorRole of bronchoconstriction in asthma
2010Honours Biological Sciences
University of Southampton
Co-SupervisorROle of bronchoconstriction in asthma
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Conjoint Associate Professor Christopher Grainge

PositionConjoint Associate Professor
School of Medicine and Public Health
Faculty of Health and Medicine
The University of Newcastle, Australia
URL:www.newcastle.edu.au/profile/christopher-grainge-778