Professor Alistair Sim

Conjoint Professor

School of Biomedical Sciences and Pharmacy (Medical Biochemistry)

Career Summary

Biography

Since my seminal work in characterising the first ever pharmacological inhibitor of protein phosphatases, I have continued to build an international and national reputation for my work that seeks to understand the ways in which these enzymes regulate cellular signalling and disease. I have made key findings in the way in which protein phosphatases respond to physiological and environmental signals and in the role these enzymes play in neurotransmission and in the initiation of asthma.

My publications have now received over 2000 citations and I am ranked in the top 15% of my field internationally. In recognition of this standing in my field I have received annual invitations to speak at key symposia at major international and national conferences. I have also established a number of mutually beneficial international collaborations in the USA and UK.

I am one of only 4 Australian researchers on the Editorial Board of The Biochemical Journal, Europes leading scientific journal for biochemistry and I sit on the Biochemistry Grant Review Panel for the National Health and Medical Research Council Australias leading medical research funding body. I have attracted funding from the Wellcome Foundation, UK to establish proteomics facilities and I am a project director of the Australian Cooperative Research Centre for Asthma and Airways new diagnostics proteomics discovery program.

I hold an international patent for anticancer therapeutics and current asthma diagnostic work is under intellectual property protection procedures.

Research Expertise
Since joining the university in 1989, I have provided national focus and international leadership in cellular signalling with a focus on the regulatory enzymes, protein phosphatases. Current focus is investigation of these key cell regulatory enzymes in the etiology and management of national priority diseases such as asthma and cancer, but also maternal health. I employ a broad range of modern molecular and cellular techniques with a major focus on proteomics for identification of molecular markers of disease

Teaching Expertise
My main teaching focus is into the medical program and the bachelor of biomedical sciences. Key expertise is in the area of cellular signaling and metabolism.

Administrative Expertise
I have occupied a broad range of senior administrative positions within my school, faculty and university.


Qualifications

  • PhD, Australian National University
  • Bachelor of Science (Honours), Aberdeen University

Keywords

  • Biochemistry
  • Cell signalling
  • Medical Biochemistry
  • asthma
  • cancer
  • cell biology
  • cell signalling
  • exocytosis
  • metabolism
  • protein kinase
  • protein phosphatase
  • protein phosphorylation
  • protein targeting
  • proteomics

Fields of Research

Code Description Percentage
060199 Biochemistry and Cell Biology not elsewhere classified 35
110199 Medical Biochemistry and Metabolomics not elsewhere classified 50
110999 Neurosciences not elsewhere classified 15

Professional Experience

Academic appointment

Dates Title Organisation / Department
1/01/2004 - 1/06/2006 Assistant Dean Research University of Newcastle
Faculty Of Health
Australia
1/01/2002 -  Associate Professor of Medical Biochemistry University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/1998 - 1/12/2001 Senior Lecturer in Medical Biochemistry University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/1992 - 1/12/1997 Lecturer in Medical Biochemistry University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/1990 - 1/12/1991 Research Fellow University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/09/1985 - 1/12/1989 Research Fellow

Biochemistry

University of Dundee, Scotland
School of Life Sciences
United Kingdom

Membership

Dates Title Organisation / Department
Member - The Biochemical Journal The Biochemical Journal
Australia
Grant Review Panel Member - NHMRC NHMRC Committee
Australia

Awards

Recognition

Year Award
2007 Protein Phosphatase Research Portal
Unknown

Invitations

Participant

Year Title / Rationale
2006 Australian Neuroscience Society Meeting
Organisation: Australian Neuroscience Society Description: This meeting is the premier Neuroscience meeting in Australia. I was an invited symposium speaker.
2006 ), The Australian Physiology and Pharmacology Society Annual Meeting
Organisation: ), The Australian Physiology and Pharmacology Society Description: This meeting is the premier Australian conference in physiology and pharmacology. I was an invited symposium speaker
2005 Combio
Organisation: Australian Society for Biochemistry and Molecular Biology Description: Combio is Australia's premier Biochemistry meeeting. I was an invited symposium speaker
2005 FEBS Europhosphatase
Organisation: Federation of European Biochemical Societies Description: The FEBS Europhosphatase meeting is the premier international meeting in my field. All speakers are invited by the organising committee
2003 FEBS Europhosphatase Meeting
Organisation: Federation of European Biochemical Societies Description: The FEBS Europhosphatase meeting is the premier international meeting in my field. All speakers are invited by the organising committee
2002 FASEB Summery Research Conference on Protein Phosphatases
Organisation: Federation of American Society for Experimental Biology Description: The FASEB Summer Research Conference is the major biennial international conference in my field. All speakers are invited by the organising committee
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (54 outputs)

Year Citation Altmetrics Link
2013 Mate K, Sim A, Weidenhofer J, Milward L, Scott J, 'Investigation of the human disease osteogenesis imperfecta: A research-based introduction to concepts and skills in biomolecular analysis', Biochemistry & Molecular Biology Education, 41 103-109 (2013) [C1]
DOI 10.1002/bmb.20672
Citations Scopus - 1
Co-authors Liz Milward, Karen Mate, Judith Weidenhofer
2011 Verrills NM, Irwin JA, He XY, Wood LG, Powell H, Simpson JL, et al., 'Identification of novel diagnostic biomarkers for asthma and chronic obstructive pulmonary disease', American Journal of Respiratory and Critical Care Medicine, 183 1633-1643 (2011) [C1]
DOI 10.1164/rccm.201010-1623OC
Citations Scopus - 50Web of Science - 46
Co-authors Peter Gibson, Nikki Verrills, Jodie Simpson, Lisa Wood, Vanessa Mcdonald
2010 Roberts KG, Smith AM, McDougall FK, Carpenter HC, Horan MP, Neviani P, et al., 'Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers', Cancer Research, 70 5438-5447 (2010) [C1]
DOI 10.1158/0008-5472.CAN-09-2544
Citations Scopus - 74Web of Science - 70
Co-authors Nikki Verrills, Leonie Ashman
2010 Kranias G, Watt L, Carpenter HC, Holst J, Ludowyke R, Strack S, et al., 'Protein phosphatase 2A carboxymethylation and regulatory B subunits differentially regulate mast cell degranulation', Cellular Signalling, 22 1882-1890 (2010) [C1]
DOI 10.1016/j.cellsig.2010.07.017
Citations Scopus - 7Web of Science - 6
Co-authors Nikki Verrills
2008 Skelding KA, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Development of a novel method for the identification of CaMKII binding proteins', Journal of Neurochemistry, 106 51 (2008) [E3]
Co-authors Kathryn Skelding, John Rostas, Nikki Verrills, Phil Dickson
2006 Sim AT, Ludowyke RI, Verrills NM, 'Mast cell function: Regulation of degranulation by serine/threonine phosphatases', Pharmacology & Therapeutics, 112 425-439 (2006) [C1]
DOI 10.1016/j.pharmthera.2006.04.011
Citations Scopus - 22Web of Science - 20
Co-authors Nikki Verrills
2006 Sim AT, Herd LM, Proctor DT, Baldwin ML, Meunier FA, Rostas JA, 'High throughput analysis of endogenous glutamate release using a fluorescence plate reader', Journal of Neuroscience Methods, 153 43-47 (2006) [C1]
DOI 10.1016/j.jneumeth.2005.10.004
Citations Scopus - 5Web of Science - 6
Co-authors Lynn Herd, John Rostas
2006 Baldwin ML, Cammarota MP, Sim AT, Rostas JA, 'Src family tyrosine kinases differentially modulate exocytosis from rat brain nerve terminals', Neurochemistry International, 49 80-86 (2006) [C1]
DOI 10.1016/j.neuint.2006.01.002
Citations Scopus - 12Web of Science - 11
Co-authors John Rostas
2006 Migues PV, Lehmann IT, Fluechter L, Cammarota MP, Gurd JW, Sim AT, et al., 'Phosphorylation of CaMKII at Thr253 occurs in vivo and enhances binding to isolated postsynaptic densities', Journal of Neurochemistry, 98 289-299 (2006) [C1]
DOI 10.1111/j.1471-4159.2006.03876.x
Citations Scopus - 25Web of Science - 23
Co-authors Phil Dickson, John Rostas
2003 Baldwin ML, Rostas JA, Sim AT, 'Two modes of excytosis from synaptosomes are differentially regulated by protein phosphatase types 2A and 2B', Journal of Neurochemistry, 85 1190-1199 (2003) [C1]
DOI 10.1046/j.1471-4159.2003.01779.x
Citations Scopus - 27Web of Science - 26
Co-authors John Rostas
2003 Bevilaqua L, Cammarota MP, Dickson PW, Sim AT, Dunkley PR, 'Role of protein phosphatase 2C from bovine adrenal chromaffin cells in the dephosphorylation of phospho-serine 40 tyrosine hydroxylase', Journal of Neurochemistry, 85 1368-1373 (2003) [C1]
DOI 10.1046/j.1471-4159.2003.01792.x
Citations Scopus - 20Web of Science - 20
Co-authors Peter Dunkley, Phil Dickson
2003 Sim ATR, Holst J, Ludowyke RI, '[10] Protein Phosphatase Translocation in RBL-2H3 Cells', Methods in Enzymology, 366 113-124 (2003)
DOI 10.1016/S0076-6879(03)66010-6
2003 Sim AT, Baldwin ML, Rostas JA, Holst J, Ludowyke RI, 'The role of serine/threonine protein phosphatases in exocytosis', Biochemical Journal, 373 641-659 (2003) [C1]
DOI 10.1042/BJ20030484
Citations Scopus - 37Web of Science - 36
Co-authors John Rostas
2002 McCluskey A, Sim A, Sakoff J, 'Serine-threonine protein phosphatase inhibitors: Development of potential therapeutic strategies', Journal of Medicinal Chemistry, 45 1151-1175 (2002) [C1]
Citations Scopus - 188Web of Science - 186
Co-authors Adam Mccluskey, Jennette Sakoff
2002 Leal R, Sim AT, Goncalves C, Dunkley PR, 'Tyrosine Hydroxylase Dephosphorylation by Protein Phosphatase 2A in Bovine Adrenal Chromaffin Cells', Neurochemical Research, 27, No 3 207-213 (2002) [C1]
Citations Scopus - 26Web of Science - 26
Co-authors Peter Dunkley
2002 McCluskey A, Atherton MA, Walkom CC, Bowyer M, Sim A, Young D, Sakoff J, 'The first two cantharidin analogues displaying PP1 selectivity', Bioorganic & Medicinal Chemistry Letters, 12 391-393 (2002) [C1]
Citations Scopus - 43Web of Science - 39
Co-authors Jennette Sakoff, Mirella Atherton, Michael Bowyer, Adam Mccluskey
2002 Sim AT, Ludowyke R, 'The Complex Nature of Protein Phosphatases', IUBMB Life, 53 283-286 (2002) [C1]
Citations Scopus - 12Web of Science - 9
2002 Holst J, Sim AT, Ludowyke R, 'Protein Phosphatases 1 and 2A Transiently Associate with Myosin during the Peak Rate of Secretion from Mast Cells', Molecular Biology of the Cell, 13 1083-1098 (2002) [C1]
Citations Scopus - 28Web of Science - 26
2001 Schillace R, Voltz J, Sim AT, Shenolikar S, Scott J, 'Multiple Interactions within the AKAP220 Signaling Complex Contribute to Protein Phosphatase 1 Regulation', Journal of Biological Chemistry, 276 No. 15 12128-12134 (2001) [C1]
Citations Scopus - 43Web of Science - 42
2001 Michell B, Chen Z-P, Tiganis T, Stapleton D, Katsis F, Power D, et al., 'Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase', Journal of Biological Chemistry, 276 17625-17628 (2001) [C1]
Citations Scopus - 394Web of Science - 366
2001 Sim AT, 'Protein Phosphatases: Regulating the Regulators', Australian Biochemist, 32 No. 1 13-15 (2001) [C1]
2000 Ludowyke RI, Holst J, Mudge L-M, Sim AT, 'Transient Translocation and Activation of Protein Phosphatase 2A during Mast Cell Secretion', The Journal of Biological Chemistry, 275 No. 9 March 3 6144-6152 (2000) [C1]
Citations Scopus - 50Web of Science - 49
2000 Lengyel I, Fieuw-Makaroff S, Hall AL, Sim AT, Rostas JA, Dunkley PR, 'Modulation of the Phosphorylation and Activity of Calcium/Calmodulin-Dependent Protein Kinase II by Zinc', Journal of Neurochemistry, 75 No. 2 594-605 (2000) [C1]
Citations Scopus - 57Web of Science - 55
Co-authors John Rostas, Peter Dunkley
2000 McCluskey A, Atherton MA, Mudgee L, Sim A, Sakoff JA, Quinn R, 'Anhydride modified cantharidin analogues. Is ring opening important in the inhibition of protein phosphatase 2A?', European Journal of Medicinal Chemistry, 35 957-964 (2000) [C1]
Citations Scopus - 44Web of Science - 40
Co-authors Adam Mccluskey, Mirella Atherton, Jennette Sakoff
2000 Bowyer MC, 'Anhydride Modified Cantharidin Analogues: Synthesis, Inhibition of Protein Phosphatases 1 and 2A and Anticancer Activity', Bioorganic & Medicinal Chemistry Letters, 10 1687-1690 (2000) [C1]
Citations Scopus - 75Web of Science - 72
Co-authors Adam Mccluskey, Michael Bowyer, Jennette Sakoff
1999 Lengyel I, Hall AL, Fieuw-Makaroff S, Sim ATR, Rostas JAP, Dunkley PR, 'Characterization of the zinc-dependent autophosphorylation sites on calcium/calmodulin-dependent protein kinase II', JOURNAL OF NEUROCHEMISTRY, 73 S33-S33 (1999)
Co-authors Peter Dunkley, John Rostas
1999 Sim AT, Scott J, 'Targeting of PKA, PKC and protein phosphatases to cellular microdomains', Cell Calcium, 26 No. 5 209-217 (1999) [C1]
Citations Web of Science - 71
1998 Capon RJ, Rooney F, Murray LM, Collins E, Sim AT, Rostas JA, et al., 'Dragmacidins: New protein phosphatase inhibitors from a Southern Australian deep-water marine sponge Spongosorites sp', Journal of Natural Products, 61 660-662 (1998) [C1]
Citations Scopus - 120Web of Science - 111
Co-authors John Rostas
1998 Sim AT, Collins E, Mudge LM, Rostas JA, 'Developmental regulation of protein phosphatase types 1 and 2A in post-hatch chicken brain', Neurochemical Research, 23(4) 487-491 (1998) [C1]
Citations Scopus - 12Web of Science - 11
Co-authors John Rostas
1998 Ludowyke RI, Sim ATR, 'Potential role of protein phosphatase PP2A in mast cell secretion', MOLECULAR BIOLOGY OF THE CELL, 9 202A-202A (1998)
1998 Collins E, Sim AT, 'Regulation of neuronal PP1 and PP2A during development.', Methods Mol Biol, 93 79-102 (1998)
DOI 10.1385/0-89603-468-2:79
1997 Goncalves CA, Hall A, Sim ATR, Bunn SJ, Marley P, Cheah TB, Dunkley PR, 'Tyrosine hydroxylase phosphorylation in digitonin permeabilised bovine adrenal chromaffin cells: The effect of protein kinase and phosphatase inhibitors on Ser-19 and Ser-40 phosphorylation.', J.Neurochem, 69 2387-2396 (1997) [C1]
Citations Scopus - 14Web of Science - 15
Co-authors Peter Dunkley
1997 Brent PJ, Herd L, Saunders H, Sim ATR, Dunkley PR, 'Protein phosphorylation and calcium uptake into rat forebrain synaptosomes: Modulation by the sigma (sigma) ligand, 1,3-ditolylguanidine', JOURNAL OF NEUROCHEMISTRY, 69 S206-S206 (1997)
Co-authors Peter Dunkley
1997 Goncalves CA, Hall A, Sim ATR, Bunn SJ, Marley PD, Cheah TB, Dunkley PR, 'Tyrosine hydroxylase phosphorylation in digitonin-permeabilised bovine adrenal chromaffin cells', JOURNAL OF NEUROCHEMISTRY, 69 S207-S207 (1997)
Co-authors Peter Dunkley
1997 Sim ATR, Collins E, Mudge LM, 'Subcellular pools of protein phosphatases in neuronal control', JOURNAL OF NEUROCHEMISTRY, 69 S163-S163 (1997)
1996 Lengyel I, Nichol KA, Sim ATR, Bennett MR, Dunkley PR, Rostas JAP, 'Characterization of protein kinase and phosphatase systems in chick ciliary ganglion', NEUROSCIENCE, 70 577-588 (1996)
DOI 10.1016/0306-4522(95)00356-8
Citations Scopus - 8Web of Science - 9
Co-authors Peter Dunkley, John Rostas
1995 BRENT PJ, HAYNES H, JARVIE PE, MUDGE L, SIM ATR, DUNKLEY PR, 'PHOSPHORYLATION OF SYNAPSIN I AND DYNAMIN IN RAT FOREBRAIN SYNAPTOSOMES - MODULATION BY SIGMA (SIGMA) LIGANDS', NEUROSCIENCE LETTERS, 191 71-74 (1995)
DOI 10.1016/0304-3940(95)11562-1
Citations Scopus - 8Web of Science - 6
Co-authors Peter Dunkley
1995 AGREZ MV, MELDRUM CJ, SIM ATR, AEBERSOLD RH, CLARK IM, CAWSTON TE, BURNS GF, 'A FIBROBLAST ELONGATION-FACTOR PURIFIED FROM COLON-CARCINOMA CELLS SHARES SEQUENCE IDENTITY WITH TIMP-1', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 206 590-600 (1995)
DOI 10.1006/bbrc.1995.1084
Citations Scopus - 13Web of Science - 16
1995 BUNN SJ, SIM ATR, HERD LM, AUSTIN LM, DUNKLEY PR, 'TYROSINE-HYDROXYLASE PHOSPHORYLATION IN BOVINE ADRENAL CHROMAFFIN CELLS - THE ROLE OF INTRACELLULAR CA2+ IN THE HISTAMINE H-1 RECEPTOR-STIMULATED PHOSPHORYLATION OF SER(8), SER(19), SER(31), AND SER(40)', JOURNAL OF NEUROCHEMISTRY, 64 1370-1378 (1995)
Citations Scopus - 34Web of Science - 36
Co-authors Peter Dunkley
1995 DUNKLEY PR, BUNN SJ, SIM ATR, AUSTIN L, HERD L, HALL A, BUCKENHAM AJ, 'INTRACELLULAR CALCIUM-DEPENDENT PHOSPHORYLATION OF TYROSINE-HYDROXYLASE IN BOVINE ADRENAL CHROMAFFIN CELLS', JOURNAL OF NEUROCHEMISTRY, 65 S5-S5 (1995)
Co-authors Peter Dunkley
1995 SIM ATR, RATCLIFFE E, ROSTAS JAP, 'DIFFERENTIAL REGULATION OF MEMBRANE-BOUND PROTEIN PHOSPHATASES IN BRAIN', JOURNAL OF NEUROCHEMISTRY, 65 S93-S93 (1995)
Co-authors John Rostas
1994 LIU JP, SIM ATR, ROBINSON PJ, 'CALCINEURIN INHIBITION OF DYNAMIN-I GTPASE ACTIVITY COUPLED TO NERVE-TERMINAL DEPOLARIZATION', SCIENCE, 265 970-973 (1994)
DOI 10.1126/science.8052858
Citations Scopus - 171Web of Science - 182
1994 SIM ATR, RATCLIFFE E, MUMBY MC, VILLAMORUZZI E, ROSTAS JAP, 'DIFFERENTIAL ACTIVITIES OF PROTEIN PHOSPHATASE TYPE-1 AND TYPE-2A IN CYTOSOLIC AND PARTICULATE FRACTIONS FROM RAT FOREBRAIN', JOURNAL OF NEUROCHEMISTRY, 62 1552-1559 (1994) [C1]
Citations Scopus - 47Web of Science - 50
Co-authors John Rostas
1994 SIM ATR, RATCLIFFE E, ROSTAS JAP, 'SELECTIVE REGULATION OF PROTEIN PHOSPHATASE-I DURING DEVELOPMENT IN CHICKEN FOREBRAIN AND CEREBELLUM', JOURNAL OF NEUROCHEMISTRY, 63 S73-S73 (1994)
Co-authors John Rostas
1993 SIM ATR, MUDGE LM, 'PROTEIN PHOSPHATASE-ACTIVITY IN CYANOBACTERIA - CONSEQUENCES FOR MICROCYSTIN TOXICITY ANALYSIS', TOXICON, 31 1179-1186 (1993)
DOI 10.1016/0041-0101(93)90133-4
Citations Scopus - 38Web of Science - 37
1993 MURRAY L, SIM ATR, ROSTAS JAP, CAPON RJ, 'ISOPALINURIN - A MILD PROTEIN PHOSPHATASE INHIBITOR FROM A SOUTHERN AUSTRALIAN MARINE SPONGE, DYSIDEA SP', AUSTRALIAN JOURNAL OF CHEMISTRY, 46 1291-1294 (1993)
Citations Scopus - 10Web of Science - 9
Co-authors John Rostas
1993 MURRAY L, SIM ATR, ROSTAS JAP, CAPON RJ, 'ISOPALINURIN - A MILD PROTEIN PHOSPHATASE INHIBITOR FROM A SOUTHERN AUSTRALIAN MARINE SPONGE, DYSIDEA SP (VOL 46, PG 1291-1294, 1993)', AUSTRALIAN JOURNAL OF CHEMISTRY, 46 1824-1824 (1993)
Co-authors John Rostas
1993 CAPON RJ, ELSBURY K, BUTLER MS, LU CC, HOOPER JNA, ROSTAS JAP, et al., 'EXTRAORDINARY LEVELS OF CADMIUM AND ZINC IN A MARINE SPONGE, TEDANIA-CHARCOTI TOPSENT - INORGANIC CHEMICAL DEFENSE AGENTS', EXPERIENTIA, 49 263-264 (1993)
DOI 10.1007/BF01923536
Citations Scopus - 24Web of Science - 24
Co-authors John Rostas
1993 SIM ATR, RATCLIFFE E, DUNKLEY PR, ROSTAS JAP, 'MEMBRANE-BOUND FORMS OF PROTEIN PHOSPHATASE TYPE-1 AND TYPE-2A HAVE LOWER ACTIVITY THAN CYTOSOLIC FORMS IN BRAIN', JOURNAL OF NEUROCHEMISTRY, 61 S136-S136 (1993)
Co-authors John Rostas, Peter Dunkley
1993 SIM ATR, LLOYD HGE, JARVIE PE, MORRISON M, ROSTAS JAP, DUNKLEY PR, 'SYNAPTOSOMAL AMINO-ACID RELEASE - EFFECT OF INHIBITING PROTEIN PHOSPHATASES WITH OKADAIC ACID', NEUROSCIENCE LETTERS, 160 181-184 (1993)
DOI 10.1016/0304-3940(93)90408-D
Citations Scopus - 18Web of Science - 19
Co-authors John Rostas, Peter Dunkley
1991 SIM ATR, DUNKLEY PR, JARVIE PE, ROSTAS JAP, 'MODULATION OF SYNAPTOSOMAL PROTEIN-PHOSPHORYLATION DEPHOSPHORYLATION BY CALCIUM IS ANTAGONIZED BY INHIBITION OF PROTEIN PHOSPHATASES WITH OKADAIC ACID', NEUROSCIENCE LETTERS, 126 203-206 (1991)
DOI 10.1016/0304-3940(91)90554-7
Citations Scopus - 27Web of Science - 29
Co-authors Peter Dunkley, John Rostas
1991 HARDIE DG, HAYSTEAD TAJ, SIM ATR, 'USE OF OKADAIC ACID TO INHIBIT PROTEIN PHOSPHATASES IN INTACT-CELLS', METHODS IN ENZYMOLOGY, 201 469-476 (1991)
Citations Web of Science - 171
1989 HAYSTEAD TAJ, SIM ATR, CARLING D, HONNOR RC, TSUKITANI Y, COHEN P, HARDIE DG, 'EFFECTS OF THE TUMOR PROMOTER OKADAIC ACID ON INTRACELLULAR PROTEIN-PHOSPHORYLATION AND METABOLISM', NATURE, 337 78-81 (1989)
DOI 10.1038/337078a0
Citations Scopus - 590Web of Science - 824
1987 JONES SMA, SIM ATR, HARDIE DG, YEAMAN SJ, 'PHOSPHORYLATION OF BRANCHED-CHAIN 2-OXO ACID DEHYDROGENASE COMPLEX IN ISOLATED HEPATOCYTES', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 144 628-633 (1987)
DOI 10.1016/S0006-291X(87)80012-8
Citations Scopus - 3Web of Science - 4
Show 51 more journal articles

Review (1 outputs)

Year Citation Altmetrics Link
2003 Sim AT, Holst J, Ludowyke RI, 'Protein Phosphatase Translocation in RBL-2H3 Cells', Methods in Enzymology (2003) [D1]

Conference (12 outputs)

Year Citation Altmetrics Link
2010 Verrills NM, Roberts KG, Smith AM, McDougall FK, Carpenter HC, Neviani P, et al., 'Targeting the tumour suppressor, PP2A, as a novel therapy for acute myeloid leukaemia', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book (2010) [E3]
Co-authors Nikki Verrills, Leonie Ashman
2009 Kranias G, Cottrell LF, Carpenter HC, Sim AT, Verrills NM, 'Protein phosphatase 2A carboxymethylation and regulatory B subunits differentially regulate mast cell degranulation', FEBS Journal (2009) [E3]
Co-authors Nikki Verrills
2009 Skelding KA, Liao X, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Functional consequences of CaMKII phosphorylation at THR253 in neurons', ANS 2009 Abstracts: Posters (2009) [E3]
Co-authors John Rostas, Phil Dickson, Kathryn Skelding, Nikki Verrills
2008 Skelding KA, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Identification of CaMKII binding proteins in brain sensitive to CaMKII phosphorylation state', Proceedings of the Australian Neuroscience Society (2008) [E3]
Co-authors Kathryn Skelding, John Rostas, Phil Dickson, Nikki Verrills
2007 Roberts KG, Ashman LK, Sim AT, Verrills NM, 'Regulation of protein phosphatase 2A (PP2A) B subunits by Bcr/Abl: Potential targets for chronic myeloid leukemia', AACR Meeting Abstracts Online (Abstracts of the 98th AACR Annual Meeting) (2007) [E3]
Co-authors Leonie Ashman, Nikki Verrills
2007 Roberts KG, Ashman LK, Sim ATR, Verrills NM, 'Altered expression of PP2A regulatory subunits in chronic myelogenous leukemia: Identifying targets for improved therapies', BLOOD (2007)
Co-authors Leonie Ashman, Nikki Verrills
2006 Rostas JAP, Migues P, Lehmann IT, Fluechter L, Cammarota M, Gurd JW, et al., 'Phosphorylation of CAMKII at Thr253 occurs in vivo and enhances binding to isolated post synaptic densities', JOURNAL OF NEUROCHEMISTRY (2006)
Co-authors John Rostas, Phil Dickson
2006 Rostas JA, Migues PV, Fluechter L, Dickson PW, Sim AT, Rawoff S, et al., 'Phosphorylation of CAMKII at T253 induced by transient global ischaemia', Proceedings of the Australian Neuroscience Society (2006) [E3]
Co-authors John Rostas, Phil Dickson
2006 Verrills NM, Carpenter HC, Sim AT, 'Disruption of Actin-containing Protein Phosphatase 2A Complexes Regulates Cell Motility in Neuroblastoma Cells', Molecular & Cellular Proteomics (2006) [E3]
Co-authors Nikki Verrills
2004 Rostas JA, Baldwin ML, Cammarota MP, Sim AT, 'The regulation of synaptosomal exocytosis by Src tyrosine kinases', Journal of Neurochemistry (2004) [E3]
Co-authors John Rostas
2004 Migues PV, Sim AT, Rostas JA, 'Changes in KCI-induced phosphorylation of AMPA and NMDA receptors during chicken brain maturation', Journal of Neurochemistry (2004) [E3]
Co-authors John Rostas
1991 SIM ATR, 'THE REGULATION AND FUNCTION OF PROTEIN PHOSPHATASES IN THE BRAIN', MOLECULAR NEUROBIOLOGY (1991)
DOI 10.1007/BF02935548
Citations Scopus - 50Web of Science - 51
Show 9 more conferences
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Research Supervision

Number of supervisions

Completed5
Current0

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2012 PhD The Role of Protein Phosphatase 2A as a Tumour Suppressor in Breast Cancer
PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2011 PhD Regulation of Mast Cell Degranulation by Protein Phosphatase 2A
PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2010 PhD Regulation of the Tumour Suppressor PP2A by Oncogenic Tyrosine Kinases
PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2004 PhD Differential Regulation of Two Modes of Synaptic Vesicle Exocytosis by Protein Phosphorylation
PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2004 PhD Yeast Two-Hybrid Analysis of Protein Phosphatase 2A Binding Proteins
PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle
Sole Supervisor
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Professor Alistair Sim

Position

Conjoint Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Medical Biochemistry

Contact Details

Email alistair.sim@newcastle.edu.au
Phone -
Fax -
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