The University of Newcastle, Australia
Available in 2019

Course handbook

Description

Provides students with an understanding of the physical pharmacy principles applied to the preparation of liquid and semi-solid dosage forms. This includes the principles applied to solutions, suspensions and emulsions, including surface tension, interfacial phenomena, surfactants, adsorption and pH. An introduction to concepts around stability/degradation and storage/preservation will be explored. Basic pharmacokinetic principles are introduced.

This course is a Compulsory Program Component that students must pass in order to progress in the Bachelor of Pharmacy (Honours) program.


Availability2019 Course Timetables

Callaghan

  • Semester 1 - 2019

Learning outcomes

On successful completion of the course students will be able to:

1. Describe the physiochemical factors affecting solutions, suspensions and emulsions.

2. Understand the basic principles of stability and degradation.

3. Understand the basic principles of storage and preservation.

4. Identify the factors influencing the rate and extent of dissolution of a drug.

5. Describe the different types of polyphasic liquid and semi-solid dosage forms used in therapeutics.

6. Discuss the influence of chemical properties of drugs and excipients on the physicochemical properties of liquid dosage forms.

7. Describe the use of pharmaceutical excipients in dosage form design.

8. Describe the basic ADME (absorption, distribution, metabolism and excretion) principles of pharmacokinetics and pharmacodynamics.


Content

  1. Solubility and factors influencing dissolution.
  2. Biopharmaceutical importance of particle size.
  3. Osmotic properties of drug solutions.
  4. Surface and interfacial properties of surfactants.
  5. Emulsions, suspensions and other dispersions.
  6. Diffusion.
  7. Rheology.
  8. Excipients including preservatives.
  9. Key principles of surface activity, preservation of multiphase systems, adsorption and rheology of pharmaceutical systems.
  10. The absorption, distribution, metabolism and excretion (ADME) principles of pharmacokinetics.

Requisite

This course is only available to students enrolled in the Bachelor of Pharmacy (Honours) program.


Assessment items

Formal Examination: Formal Exam *

In Term Test: Examination: Mid-Semester *

Quiz: Quiz - Class

* This assessment has a compulsory requirement.


Compulsory Requirements

In order to pass this course, each student must complete ALL of the following compulsory requirements:

General Course Requirements:

  • Practical: Induction Requirement - Students must attend and pass the induction requirements before attending these sessions. - In order to participate in this course students must complete a compulsory safety induction.

Course Assessment Requirements:

  • In Term Test: Pass Requirement - Students must pass this assessment item to pass the course. - Students must pass the combination of the mid-semester and formal examination and pass the course overall to be able to pass the course.
  • Formal Examination: Pass Requirement - Students must pass this assessment item to pass the course. - Students must pass the combination of the mid-semester and formal examination and pass the course overall to be able to pass the course.

Contact hours

Callaghan

Lecture

Face to Face On Campus 3 hour(s) per Week for 12 Weeks

Practical

Face to Face On Campus 2 hour(s) per Week for 12 Weeks