Available in 2021
Course code



10 units


1000 level

Course handbook


Provides students with an understanding of the physical pharmacy principles applied to the preparation of liquid and semi-solid dosage forms. This includes the principles applied to solutions, suspensions and emulsions, including surface tension, interfacial phenomena, surfactants, adsorption and pH. An introduction to concepts around stability/degradation and storage/preservation will be explored. Basic pharmacokinetic principles are introduced.

This course is a Compulsory Program Component that students must pass in order to progress in the Bachelor of Pharmacy (Honours) program.

Availability2021 Course Timetables


  • Semester 1 - 2021

Learning outcomes

On successful completion of the course students will be able to:

1. Describe the physiochemical factors affecting solutions, suspensions and emulsions.

2. Understand the basic principles of stability and degradation.

3. Understand the basic principles of storage and preservation.

4. Identify the factors influencing the rate and extent of dissolution of a drug.

5. Describe the different types of polyphasic liquid and semi-solid dosage forms used in therapeutics.

6. Discuss the influence of chemical properties of drugs and excipients on the physicochemical properties of liquid dosage forms.

7. Describe the use of pharmaceutical excipients in dosage form design.

8. Describe the basic ADME (absorption, distribution, metabolism and excretion) principles of pharmacokinetics and pharmacodynamics.

9. Discuss how pharmacodynamics and pharmacokinetics are interrelated.


  1. Solubility and factors influencing dissolution.
  2. Biopharmaceutical importance of particle size.
  3. Osmotic properties of drug solutions.
  4. Surface and interfacial properties of surfactants.
  5. Emulsions, suspensions and other dispersions.
  6. Diffusion.
  7. Rheology.
  8. Excipients including preservatives.
  9. Key principles of surface activity, preservation of multiphase systems, adsorption and rheology of pharmaceutical systems.
  10. The absorption, distribution, metabolism and excretion (ADME) principles of pharmacokinetics.
  11. An introduction to pharmacodynamics.


This course is only available to students enrolled in the Bachelor of Pharmacy (Honours) program.

Assessment items

Formal Examination: Formal Exam

In Term Test: Examination: Mid-Semester

Quiz: Quiz - Class

Compulsory Requirements

In order to pass this course, each student must complete ALL of the following compulsory requirements:

General Course Requirements:

  • Practical: Induction Requirement - Students must attend and pass the induction requirements before attending these sessions. - In order to participate in this course students must complete a compulsory safety induction.

Contact hours



Face to Face On Campus 38 hour(s) per Term Full Term

3 hours per week for 12 weeks and 2 hours for 1 week (in term examination)


Face to Face On Campus 2 hour(s) per Week for 12 Weeks

The University of Newcastle acknowledges the traditional custodians of the lands within our footprint areas: Awabakal, Darkinjung, Biripai, Worimi, Wonnarua, and Eora Nations. We also pay respect to the wisdom of our Elders past and present.