Not currently offered
Course code

EPID6770

Units

10 units

Level

6000 level

Course handbook

Description

This course will cover the following material:

1. Basic concepts in genetics and molecular biology

2. The use of biomarkers in medicine and research.

3. How to determine if there is a genetic component to a disease or trait?

4. Identifying genes associated with complex disease - historical aspects

5. Identifying genes associated with complex disease - association studies (incl. GWAS)

6. Identifying genes associated with complex disease - Polygenic analysis

7. Following up GWAS hits - what to do with GWAS findings

8. Beyond GWAS (Next generation sequencing, epigenetics etc)

9. Disease prediction in the genomic era

10. Guidelines for genetic testing in populations.


Availability

Not currently offered.


Replacing course(s)

This course replaces the following course(s): EPID6440. Students who have successfully completed EPID6440 are not eligible to enrol in EPID6770.


Learning outcomes

On successful completion of the course students will be able to:

1. Basic concepts in genetics and molecular biology

2. The use of biomarkers in medicine and research.

3. How to determine if there is a genetic component to a disease or trait?

4. The historical aspects involved in Identifying genes associated with complex disease.

5. The use of association studies to identifying genes associated with complex disease (incl. GWAS studies)

6. The use of polygenic analysis for identifying genes associated with complex disease.

7. How to following up GWAS hits ¿ what to do with GWAS findings?

8. What are the modern alternatives to GWAS (Next generation sequencing, epigenetics etc) for identifying the role of genes in disease.

9. How to use genetic information in disease prediction.

10. The role of genetic testing in populations.


Content

This course will cover the following material:

  1. Basic concepts in genetics and molecular biology
  2. The use of biomarkers in medicine and research.
  3. How to determine if there is a genetic component to a disease or trait?
  4. Identifying genes associated with complex disease " historical aspects
  5. Identifying genes associated with complex disease " association studies (incl. GWAS)
  6. Identifying genes associated with complex disease " Polygenic analysis
  7. Following up GWAS hits " what to do with GWAS findings
  8. Beyond GWAS (Next generation sequencing, epigenetics etc)
  9. Disease prediction in the genomic era
  10. Guidelines for genetic testing in populations.

Requisite

This course is only available to students enrolled in the G Dip Clinical Epidemiology or M Clinical Epidemiology programs. Pre-requisite - successful completion of BIOS6910


Assumed knowledge

A first year university biology, biomedical science, or medicine student knowledge of genetics and molecular biology is advisable but not a prerequisite as this will be introduced during the course.


Assessment items

Written Assignment: Essays / Written Assignments