Preclinical Neurobiology


MEMBER

Emeritus Professor John Rostas

Emeritus Professor John Rostas


OVERVIEW

The research area is the molecular mechanisms responsible for regulating neuronal function during development, plasticity and ischaemic/excitotoxic damage.

The main research focus is on the role and regulation of the important regulatory enzyme CaMKII.

The group have identified a new mechanism (autophosphorylation of CaMKII at T253) that controls the function of CaMKII in vivo through molecular targeting.

The group have shown that this mechanism regulates cell proliferation and is selectively activated in brain tissue by ischaemia and excitotoxity.

The current research explores the mechanisms by which this new regulatory mechanism controls cell death in the brain following stroke and the therapeutic potential of drugs that interfere with this regulatory mechanism.