Jie Zhong Chen
Hessam Tabatabaeehatambakhsh, Jennifer Latham, Simonne Sherwin, Amanda Croft
Xu Guang Yan
Chun Yan Wang, Yuan Yuan Zhang, Jia Yu Wang, Hamed Yari, Ting La, Su Tang Guo
Fu Xi Lei, Fen Liu
Melanoma is the most serious form of skin cancer that is often referred to as Australia's national cancer as Australia has the highest incidence of melanoma in the world.
However, there is currently no curative treatment once the disease spreads beyond the original site.
To address this major Australian health problem, the laboratory has been working on translational melanoma research with a focused theme of “overcoming resistance of metastatic melanoma to treatment”.
Specifically, the group are working on overcoming resistance of melanoma cells to programmed cell death induced by newly developed targeted therapeutic drugs and immunotherapeutic agents.
The group have initiated a number of new projects that advance the frontier of melanoma research.
These include “apoptosis-regulating long non-coding RNAs in melanoma”, “targeting resistance mechanisms of quiescent melanoma cells to programmed cell death”, “co-targeting CD47 and the MAPK pathway or PD-1/PD-L1 in the treatment of melanoma”, and “regulation of immune checkpoints in melanoma”.