Melanoma Research


MEMBERS

Professor Xu Dong Zhang

Professor Xu Dong Zhang

Research Fellows

Chen Chen Jiang

Lei Jin

Jie Zhong Chen

Lab Manager

Margaret Farrelly

Research Assistants

Hessam Tabatabaeehatambakhsh, Jennifer Latham, Simonne Sherwin, Amanda Croft

Pathology Technician

Xu Guang Yan

PhD Students

Chun Yan Wang, Yuan Yuan Zhang, Jia Yu Wang, Hamed Yari, Ting La, Su Tang Guo

Visiting Students

Fu Xi Lei, Fen Liu


OVERVIEW

Melanoma is the most serious form of skin cancer that is often referred to as Australia's national cancer as Australia has the highest incidence of melanoma in the world.

However, there is currently no curative treatment once the disease spreads beyond the original site.

To address this major Australian health problem, the laboratory has been working on translational melanoma research with a focused theme of “overcoming resistance of metastatic melanoma to treatment”.

Specifically, the group are working on overcoming resistance of melanoma cells to programmed cell death induced by newly developed targeted therapeutic drugs and immunotherapeutic agents.

The group have initiated a number of new projects that advance the frontier of melanoma research.

These include “apoptosis-regulating long non-coding RNAs in melanoma”, “targeting resistance mechanisms of quiescent melanoma cells to programmed cell death”, “co-targeting CD47 and the MAPK pathway or PD-1/PD-L1 in the treatment of melanoma”, and “regulation of immune checkpoints in melanoma”.