Inflammation and Oxidation in chronic diseases


Dr Dean Sculley

Lecturer Dean Sculley

PhD Students

Brendan Scott, Chris Stevens, Andrew Novak


The laboratory research is centred on the roles inflammation and oxidation play in the development of chronic diseases.

The main focus is on periodontal disease and its function as a risk factor in many chronic diseases such as coronary heart disease, rheumatoid arthritis and type II diabetes.

One area of research is focused on activated complement proteins, specifically C5a, and it’s role as an anaphylatoxin and chemoattractant for neutrophils in rheumatoid arthritis patients.

In addition, this research is investigating nutritional modulation of the inflammatory cascade and antioxidant capacity, with the goal of identifying key dietary factors and their effects on reducing chronic inflammation and increasing systemic antioxidant capacity.

The group’s research also involves the role exercise plays in reducing chronic inflammation and increasing antioxidant capacity.

Current studies include the effects of activity levels on systemic inflammatory markers, plasma and saliva antioxidant capacities, white blood cell counts and their relationship to chronic disease states in a large cohort.