Gynaecology Oncology Laboratory
Manish Kumar, Shafiq Syed, Jyoti Goad, Ayesha Ali, Preety Bajwa, Subhransu Sahoo, Prathima Nagendra, Arnab Ghosh, Mariam Adebayo, Lisa Sercombe, Yazmin Crossingham
The major focus of the group’s research program is to develop new drugs for the treatment of gynaecological cancers (ovarian and uterine cancers).
The group are using genetically modified mouse models, cancer patient derived xenograft models and primary human tissue samples to define the molecular and cellular events involved in carcinogenesis and then using this knowledge to develop targeted therapies to improve clinical outcomes in human patients.
The current research focuses on:
- Role of microenvironment in ovarian and uterine cancers
- Wnt-P13K-mTOR signalling axis in ovarian and uterine cancers
- Cancer stem cells in ovarian and uterine cancers
- Circulating tumour cells in ovarian and endometrial cancer
- Pathogenesis of germ cell tumours
This work showed that loss of tumour suppressor genes guarding the mTOR pathway occurs, at both genomic and protein level, in ~60% of human serous ovarian cancer patients and similar alterations in mice also causes the development of serous ovarian cancer.