Gynaecology Oncology Laboratory
Muhammad Jamaluddin, Arnab Ghosh, Manish Kumar Jhamb, Shafiq Syed
Lisa Sercombe, Yazmin Crossingham, Isabella Moore, Varshini D. Venkata, Yohannes K. Emiru, Fatemeh Hashemi, Aminah Ali Abid Al-Juboori
The major focus of the group’s research program is to develop early detection tests and new treatments of gynaecological diseases including ovarian and endometrial cancers.
The group are using genetically modified preclinical models, cancer patient derived xenograft models and primary human tissue samples to define the molecular and cellular events involved in pathogenesis and then using this knowledge to develop targeted therapies to improve clinical outcomes in human patients.
The current research focuses on:
- Early detection tests for gynaecological diseases
- Role of microenvironment in ovarian and uterine cancers
- Wnt-P13K-mTOR signalling axis in ovarian and uterine cancers
- Cancer stem cells in ovarian and uterine cancers
- Pathogenesis of endometriosis
This work showed that loss of tumour suppressor genes guarding the mTOR pathway occurs, at both genomic and protein level, in ~60% of human serous ovarian cancer patients and similar alterations in mice also causes the development of serous ovarian cancer.