Cancer and Common Disease Genomics
Alex Xavier, Sommer, Brianna Morten, Abdullah Noraidatulakma, Nadine Berry, Benjamin Kamien
Inherited forms of cancer have been Professor Scott’s main interest for around 25 years. The research has first focused on the identification of genes associated with inherited forms of colorectal cancer and breast cancer. The research area proved to be extremely successful as it really set the scene for the group’s current understanding of the genetic basis of malignancy.
Since the identification of genetic susceptibilities the research has focused on better defining these inherited entities such that more appropriate intervention strategies can be developed. Initially, much emphasis was placed on recognising genotype/phenotype correlations with disease and as such the research undertaken has done much to define such relationships. More recently, the role of modifier genes in disease penetrance has been a major thematic area and data forthcoming from these studies indicates that there are additional disease susceptibilities that are important in assessing individual risk on a genetic background of high risk. This research is now beginning to be translated to the general population as it represents the first tentative move towards determining cancer risk in the general population. With increasing emphasis on disease prevention it is to be expected that this research will continue to flourish.
Over the past 10 years Professor Scott’s work has diversified and developed into studies that are associated with a better understanding of the genetic basis of common diseases (that include in addition to cancer other diseases such as multiple sclerosis, schizophrenia and stroke, to name but a few).
The group published 52 manuscripts in high quality international journals in 2015 and presented work at many national/international conferences.