Conjoint Prof. Stephen Ackland

Work Phone	(02) 4921 1146
Fax	(02) 4968 0384
Email	Stephen.Ackland@newcastle.edu.au
Office	NM2, Mater Hospital Level 3 - New Med 2

Highlighted Publications

Year	Citation	Nova
2006	Wong M, Balleine R L, Blair E Y L, McLachlan A J, Ackland Stephen, Garg M, Evans S, Farlow D, Collins M, Rivory L P, Hoskins J M, Mann G J, Clarke C L, Gurney H, 'Predictors of vinorelbine pharmacokinetics and pharmacodynamics in patients with cancer', Journal of Clinical Oncology, 24 2448-2455 (2006) [C1]

Publications

For items published while at an institution other that the University of Newcastle, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Chapters In A Book (1 outputs)

Chapter in A2 Book (B2) (1 outputs)

Year	Citation	Nova
2003	Ackland Stephen, Beale P, Godefridus Jp, 'Thymidylate synhase inhibitors', Cancer chemotherapy and Biological response modifiers, Elsevier BV, netherlands, 1-28 (2003) [B2]

Journal Articles (53 outputs)

Refereed Article in a Scholarly Journal (C1) (44 outputs)

Year	Citation	Nova
2012	Garg M B, Lincz Lisa, Adler K, Scorgie F E, Ackland Stephen, Sakoff Jennette Anne, 'Predicting 5-Fluorouracil toxicity in colorectal cancer patients from peripheral blood cell telomere length - A multivariate analysis', British Journal of Cancer, 107 1525-1533 (2012) [C1]
2012	Goldstein D, Spry N, Cummins M M, Brown C, Van Hazel G A, Carroll S, Selva-Nayagam S, Borg M, Ackland Stephen, Wratten C, Shapiro J, Porter I W T, Hruby G, Horvath L, Bydder S, Underhill C, Harvey J, Gebski V J, Australasian Gastro-Intestinal Trials Group, 'The GOFURTGO Study: AGITG Phase II Study of fixed dose rate gemcitabine-oxaliplatin integrated with concomitant 5FU and 3-D conformal radiotherapy for the treatment of localised pancreatic cancer', British Journal of Cancer, 106 61-69 (2012) [C1]
2012	Ngan Samuel Y, Burmeister Bryan, Fisher Richard J, Solomon Michael, Goldstein David, Joseph David, Ackland Stephen, Schache David, McClure Bev, McLachlan Sue-Anne, McKendrick Joseph, Leong Trevor, Hartopeanu Cris, Zalcberg John, Mackay John, 'Randomized trial of short-course radiotherapy versus long-course chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: Trans-Tasman Radiation Oncology Group Trial 01.04', Journal of Clinical Oncology, 30 3827-3833 (2012) [C1]
2012	Zdenkowski Nicholas, Chen Stanley, Van Der Westhuizen Andre, Ackland Stephen, 'Curative strategies for liver metastases from colorectal cancer: A review', Oncologist, 17 201-211 (2012) [C1]
2011	Agrez Michael, Garg Madhu, Dorahy Douglas, Ackland Stephen, 'Synergistic anti-tumor effect of cisplatin when combined with an anti-src kinase integrin-based peptide', Journal of Cancer Therapy, 2 295-301 (2011) [C1]
2011	Garg Madhu B, Ackland Stephen, 'Pyridoxine to protect from oxaliplatin-induced neurotoxicity without compromising antitumour effect', Cancer Chemotherapy and Pharmacology, 67 963-966 (2011) [C1]
2011	Garg Madhu Bala, Sakoff Jennette Anne, Ackland Stephen, 'A simple HPLC method for plasma level monitoring of mitotane and its two main metabolites in adrenocortical cancer patients', Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 879 2201-2205 (2011) [C1]
2011	Goldstein David, Gainford M Corona, Brown Chris, Tebbutt Niall, Ackland Stephen, Van Hazel Guy, Jefford Michael, Abdi Ehtesham, Selva-Nayagam Sid, Gebski Val, Miller Danielle, Shannon Jenny, 'Fixed-dose-rate gemcitabine combined with cisplatin in patients with inoperable biliary tract carcinomas', Cancer Chemotherapy and Pharmacology, 67 519-525 (2011) [C1]
2011	Lee C K, Hudson M, Stockler M, Coates A S, Ackland Stephen, Gebski V, Lord S, Friedlander M, Boyle F, Simes R J, 'A nomogram to predict survival time in women starting first-line chemotherapy for advanced breast cancer', Breast Cancer Research and Treatment, 129 467-476 (2011) [C1]
2011	Stockler Martin R, Harvey Vernon J, Francis Prudence A, Byrne Michael J, Ackland Stephen, Fitzharris Bernie, Van Hazel Guy, Wilcken Nicholas R C, Grimison Peter S, Nowak Anna K, Gainford M Corona, Fong Akiko, Paksec Lisa Anne, Sourjina Tatiana, Zannino Diana, Gebski Val, Simes R John, Forbes John Frederick, Coates Alan S, 'Capecitabine versus classical cyclophosphamide, methotrexate, and fluorouracil as first-line chemotherapy for advanced breast cancer', Journal of Clinical Oncology, 29 4498-4504 (2011) [C1]
2010	De Bock Charles Edo, Garg Manohar Lal, Scott Naomi Marie, Sakoff Jennette Anne, Scorgie Fiona Emily, Ackland Stephen, Lincz Lisa, 'Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo', Pharmacogenomics Journal 1-8 (2010) [C1]
2010	Tebbutt Niall C, Wilson Kate, Gebski Val J, Cummins Michelle M, Zannino Dianna, Van Hazel Guy A, Robinson Bridget, Broad Adam, Ganju Vinod, Ackland Stephen, Forgeson Garry, Cunningham David, Saunders Mark P, Stockler Martin R, Chua Yujo, Zalcberg John R, Simes R John, Price Timothy J, 'Capecitabine, bevacizumab, and mitomycin in first-line treatment of metastatic colorectal cancer: Results of the Australasian Gastrointestinal Trials Group Randomized Phase III MAX Study', Journal of Clinical Oncology, 28 3191-3198 (2010) [C1]
2009	Ackland Stephen, Bull James M, Boyle Frances M, 'Nab-Paclitaxel: A bright new sparc in taxane therapy of cancer', Asia-Pacific Journal of Clinical Oncology, 5 147-150 (2009) [C1]
2007	Davis A J, Brew S, Gebski V J, Lewis C R, Moylan E, Parnis F X, Ackland Stephen, 'Multicenter phase II study of combination chemotherapy with capecitabine and intravenous vinorelbine in patients with pretreated metastatic breast cancer', Asia-Pacific Journal of Clinical Oncology, 3 37-43 (2007) [C1]
2007	Findlay M, Sharples K, Riley G A, Simpson A, Ackland Stephen, Hall K, Isaacs R, Humm G, McKeage M J, 'Capecitabine and oral cyclophosphamide: A novel oral treatment combination for advanced cancer', Asia-Pacific Journal of Clinical Oncology, 3 99-105 (2007) [C1]
2007	Hill Timothy Adrian, Stewart Scott Gordon, Ackland Stephen, Gilbert J, Sauer Benjamin, Sakoff Jennette Anne, McCluskey Adam, 'Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation', Bioorganic and Medicinal Chemistry, 15 6126-6134 (2007) [C1]
2007	Hill Timothy Adrian, Stewart Scott Gordon, Sauer Benjamin, Gilbert J, Ackland Stephen, Sakoff J A, McCluskey Adam, 'Heterocyclic substituted cantharidin and norcantharidin analogues-synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity', Bioorganic and Medicinal Chemistry Letters, 17 3392-3397 (2007) [C1]
2007	Lincz Lisa, Scorgie Fiona Emily, Madhu B Garg, Ackland Stephen, 'Identification of a novel single nucleotide polymorphism in the second tandem repeat sequence of the thymidylate synthase 2R allele', International Journal of Cancer, 120 1930-1934 (2007) [C1]
2007	Stewart Scott Gordon, Hill Timothy Adrian, Gilbert Jayne, Ackland Stephen, Sakoff Jennette A, McCluskey Adam, 'Synthesis and biological evaluation of norcantharidin analogues: Towards PP1 selectivity', Bioorganic and Medicinal Chemistry, 15 7301-7310 (2007) [C1]
2007	Temmink O H, Hoebe E K, Van Der Born K, Ackland Stephen, Fukushima M, Peters G J, 'Mechanism of trifluorothymidine potentiation of oxaliplatin-induced cytotoxicity to colorectal cancer cells', British Journal of Cancer, 96 231-240 (2007) [C1]
2007	Young J M, Leong D C, Armstrong K, O'Connell D, Armstrong B K, Spigelman A D, Ackland Stephen, Chapuis P, Kneebone A B, Solomon M J, 'Concordance with national guidelines for colorectal cancer care in New South Wales: a population-based patterns of care study', Medical Journal of Australia, 186 292-295 (2007) [C1]
2006	Ackland Stephen, Clarke S J, Beale P, Peters G J, 'Thymidylate synthase inhibitors', Update on Cancer Therapeutics, 1 403-427 (2006) [C1]
2006	Goldstein D, Ackland Stephen, Bell D R, Olver I N, Davis I D, Rosenthal M A, Toner G C, Pinel M C, Byrne M, 'Phase II study of vinflunine in patients with metastatic renal cell carcinoma', Investigational New Drugs, 24 429-434 (2006) [C1]
2006	Wong M, Balleine R L, Blair E Y L, McLachlan A J, Ackland Stephen, Garg M, Evans S, Farlow D, Collins M, Rivory L P, Hoskins J M, Mann G J, Clarke C L, Gurney H, 'Predictors of vinorelbine pharmacokinetics and pharmacodynamics in patients with cancer', Journal of Clinical Oncology, 24 2448-2455 (2006) [C1]
2005	Ackland S P, Jones M, Tu D, Simes J, Yuen J, Sargeant A, Dhillon H, Goldberg H, Abdi E, Shepherd L, Moore M J, 'A meta-analysis of two randomised trials of early chemotherapy in asymptomatic metastatic colorectal cancer', British Journal of Cancer, 93 1236-1243 (2005) [C1]
2005	Odelli C, Burgess D, Bateman L, Hughes A, Ackland S P, Gillies J, Collins C E, 'Nutrition support improves patient outcomes, treatment tolerance and admission characteristics in oesophageal cancer', Clinical Oncology, 17 639-645 (2005) [C1]
2005	Burmeister Bryan H, Smithers B Mark, Gebski Val, Fitzgerald Lara, Simes R John, Devitt Peter, Ackland Stephen, Gotley David C, Joseph David, Millar Jeremy, North John, Walpole Evan T, Denham James, 'Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: A randomised controlled phase III trial', Lancet Oncology, 6 659-668 (2005) [C1]
2004	Liu J J, Kestell P, Findlay M, Riley G, Ackland S, Simpson A, Isaacs R, McKeage M J, 'Application of liquid chromatography-mass spectrometry to monitoring plasma cyclophosphamide levels in phase I trial cancer patients', Clinical and Experimental Pharmacology and Physiology, 31 677-682 (2004) [C1]
2004	Lincz Lisa, Scorgie Fe, Sakoff Ja, Fagan K, Ackland Stephen, Enno A, 'Telomere length predicts neutrophil recovery in absence of G-CSF after autologous peripheral blood stem cell transplantation', Bone Marrow Transplant, 34 439-445 (2004) [C1]
2004	O'Brien Mer, Wigler N, Inbar M, Rosso R, Grischke E, Santoro A, Catane R, Kieback Dg, Tomczak P, Ackland Stephen, Orlandi F, Mellars L, Alland L, Tendler C, 'Reduced cardiotoxicity and comparable efficacy in a phase 3 trial of pegylated liposomal doxorubicine HCI (CAELYX / Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer', Annals of Oncology, 15 440-449 (2004) [C1]
2004	Sakoff Jennette Anne, Howitt I J, Ackland Stephen, McCluskey Adam, 'Serine/threonine protein phosphatase inhibition enhances the effect of thymidylate synthase inhibition', Cancer Chemotherapy and Pharmacology, 53 225-232 (2004) [C1]
2003	Denham James, Steigler A, Kilmurray J, Wratten Christopher, Burmeister B, Lam D, Joseph D, Delaney G, Christie David Gordon, Jamieson G G, Smithers B M, Ackland Stephen, Walpole E, 'Relapse patterns after chemo-radiation for carcinoma of the oesophagus', Clinical Oncology, 15 98-108 (2003) [C1]
2003	McCluskey Adam, Ackland Stephen, Bowyer Michael Christian, Baldwin Monique Louise, Garner James Andrew, Walkom Cecilia Clare, Sakoff Jennette Anne, 'Cantharidin analogues: synthesis and evaluation of growth inhibition in a panel of selected tumour cell lines', Bioorganic Chemistry, 31 66-77 (2003) [C1]
2002	Clarke S J, Abratt R, Goedhals L, Boyer M J, Milward M J, Ackland Stephen, 'Phase II trial of pemetrexed disodium (ALIMTA, LY231514) in chemotherapy-na¿ve patients with advanced non-small-cell lung cancer', Annals of Oncology, 13 737-741 (2002) [C1]
2002	Garg Madhu B, Sevester Jade C, Sakoff Jeanette A, Ackland Stephen, 'Rapid and simple chromatographic method for the determination of uracil and dihydrouracil plasma levels: A potential pretreatment predictor of 5FU toxicity', Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Science, 774 223-230 (2002) [C1]
2002	Marx G, Lewis C, Hall K, Levi J, Ackland Stephen, 'Phase I study of docetaxel plus ifosfamide in patients with advanced cancer', British Journal of Cancer, 87 846-849 (2002) [C1]
2002	Rischin D, Ackland Stephen, Smith J, Garg M B, Clarke S J, Millward M J, Toner G, Zalcberg J, 'Phase I and pharmacokinetic study of docetaxel in combination with epirubicin and cyclophosphamide in advanced cancer: dose escalation possible with G-CSF but not with prophylactic antibiotics', Annals of Oncology, 13 1810-1818 (2002) [C1]
2002	Sakoff Ja, De Waal E, Garg Mb, Denham James, Scorgie Fe, Enno A, Lincz Lisa, Ackland Stephen, 'Telomere Length in Haemopoietic Stem Cells can be Determined from that of Mononuclear Blood Cells or Whole Blood', Leukemia and Lymphoma, 43(10) 2017-2020 (2002) [C1]
2002	Talbot D C, Moiseyenko V, Van Belle S, O'Reilly S M, Alba Conejo E, Ackland Stephen, Eisenberg P, Melnychuk D, Pienkowski T, Burger H-U, Laws S, Osterwalder B, 'Randomised, phase II trial comparing oral capecitabine (Xeloda) with paclitaxel in patients with metastatic/advanced breast cancer pretreated with anthracyclines', British Journal of Cancer, 86 1367-1372 (2002) [C1]
2001	McCluskey A, Ackland S P, Gardiner E, Walkom C C, Sakoff J A, 'The inhibition of protein phosphatases 1 and 2A: A new target for rational anti-cancer drug design?', Anti-Cancer Drug Design, 16 291-303 (2001) [C1]
2001	Ackland Stephen, Anton A, Breitbach Gp, Colajori E, Tursi Jm, Delfino C, Efremedis A, Fittipaldo A, Kolaric K, Lopez M, Viaro D, Hepi 013 Study Group -, 'Dose-intensive epirubicin-based chemotherapy is superior to an intensive intravenous cyclophoshamide, methotrexate, and fluorouracil regimen in metastatic breast cancer: A randomized multinational study', Journal of Clinical Oncology, 19 943-953 (2001) [C1]
2001	McCluskey A, Walkom C, Bowyer M, Ackland Stephen, Gardiner E, Sakoff J, 'Cantharimides: A New Class of Modified Cantharidin Analogues Inhibiting Protein Phosphatases 1 and 2A', Bioorganic & Medicinal Chemistry Letters, 11 2941-2946 (2001) [C1]
2000	Garg Mb, Ackland Stephen, 'Simple and sensitive high-performance liquid chromatography method for the determination of docetaxel in human plasma or urine', Journal of Chromatography B, 748 383-388 (2000) [C1]
2000	Sakoff Ja, Ackland Stephen, 'Thymidylate synthase inhibition induces S-phase arrest, biphasic mitochondrial alterations and caspase-dependent apoptosis in leukaemia cells', Cancer Chemotherapy and Pharmacology, 46 477-487 (2000) [C1]

Non Refereed Article in a Scholarly Journal (C2) (1 outputs)

Year	Citation	Nova
2000	Peters Gj, De Bruin M, Fukushima M, Van Triest B, Hoekman K, Pinedo Hm, Ackland Stephen, 'Thymidine phosphorylase in angiogenesis and drug resistance', Advances in Experimental Medicine and Biology, 486 291-294 (2000) [C2]

Non Refereed Article in a Professional Journal (C3) (8 outputs)

Year	Citation	Nova
2012	Ackland Stephen, Fukuda Yuko, '2011: Year in review - From rabbits to dragons', Asia-Pacific Journal of Clinical Oncology, 8 1-2 (2012) [C3]
2011	Ackland Stephen, 'Cancer in Australia: A model for other Asia-Pacific countries', Asia-Pacific Journal of Clinical Oncology, 7 323-324 (2011) [C3]
2011	Vilain Ricardo Enrique, Dudding Tracy Elizabeth, Braye Stephen Geoffrey, Groombridge Claire, Meldrum C, Spigelman Allan David, Ackland Stephen, Ashman Leonie Kay, Scott Rodney, 'Can a familial gastrointestinal tumour syndrome be allelic with Waardenburg syndrome?', Clinical Genetics, 79 554-560 (2011) [C3]
2009	Ackland Stephen, 'Molecular biomarkers in non-small cell lung cancer: Pointing the way to better outcomes from treatment', Asia-Pacific Journal of Clinical Oncology, 5 213-214 (2009) [C3]
2008	Vilain Richard E, Ackland Stephen, 'Gastrointestinal stromal tumors - A model for understanding solid tumor biology and development of targeted therapies, or just another low-hanging fruit?', Asia-Pacific Journal of Clinical Oncology, 4 185-187 (2008) [C3]
2007	Carrington C, Carlton J, Ackland Stephen, 'Preventing chemotherapy errors: Implementing system changes', Asia-Pacific Journal of Clinical Oncology, 3 57-58 (2007) [C3]
2007	Lincz Lisa, Scorgie Fiona Emily, Garg Manohar Lal, Ackland Stephen, 'Reply to the letter to the editor 'Classification of thymidylate synthase gene enhancer region polymorphisms'', International Journal of Cancer, 121 2581-2582 (2007) [C3]
2006	Ackland Stephen, 'Cervical carcinoma: A common and preventable problem in developing countries (Editorial)', Asia-Pacific Journal of Clinical Oncology, 2 69-70 (2006) [C3]

Conference Publication (15 outputs)

Extract of Paper (E3) (15 outputs)

Year	Citation	Nova
2012	Goddard Emma M, Dhillon Haryana M, Turner Jane, Kabourakis Michael, Beale Philip J, Goodwin Annabel, Goldstein David, Clarke Stephen J, Ouriques Myra, Ackland Stephen, Abell Fiona, Bonaventura Antonio, Mallesara G, Fischer Clare, Kreiger Laurence, Lashbrook Marie, Vardy Janette L, 'The impact of physical activity on disease-free survival in patients with high-risk stage II or III colon cancer: One month screening results', Asia-Pacific Journal of Clinical Oncology, Brisbane (2012) [E3]
2012	Sakoff Jennette Anne, Garg Madhu Bala, Lincz Lisa, Adler K, Scorgie Fiona Emily, Ackland Stephen, 'Predicting chemotherapy-induced toxicity in cancer patients from peripheral blood telomere length', European Journal of Cancer, Barcelona, Spain (2012) [E3]
2012	Upanal Nazeerahamad Nabisaheb, Ackland Stephen, Bonaventura Anthony, McElduff Patrick, 'Improved clinical outcomes in metastatic colorectal cancer patients on first-line chemotherapy with bevacizumab can be predicted by early rise in blood pressure', Asia-Pacific Journal of Clinical Oncology, Brisbane, Queensland (2012) [E3]
2010	Ackland Stephen, 'Challenges in clinical trials design and management in the 21st century', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
2010	Garg Madhu, Sakoff Jennette Anne, Ackland Stephen, 'A simple HPLC method to measure plasma mitotane and its two main metabolites in adrenocortical cancer patients', AACR 101st Annual Meeting 2010. Abstracts, Washington, DC (2010) [E3]
2010	Sakoff Jennette Anne, Garg Madhu, Adler Kim, Scorgie Fiona Emily, Lincz Lisa, Ackland Stephen, 'Short telomeres in PBMNC predicts for haematological toxicity in colorectal cancer patients treated with 5FU', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
2010	Sakoff Jennette Anne, Garg Madhu, Adler Kim, Scorgie Fiona Emily, Lincz Lisa, Ackland Stephen, 'Telomere length in peripheral blood mononuclear cells (PBMNC) predicts for leukopenia, neutropenia and mucositis in colorectal cancer patients treated with 5FU', AACR 101st Annual Meeting 2010. Abstracts, Washington, DC (2010) [E3]
2007	Ackland Stephen, Dhillon H, Jakob L, 'The COSA and Cooperative Groups Enabling Project: What is intended to be accomplished', Asia Pacific Journal of Clinical Oncology, Adelaide, SA (2007) [E3]
2007	Ackland Stephen, Dhillon Haryana, 'Improving processes across all Cancer Cooperative Trials Groups through Standard Operating Procedures (SOPS)', Asia Pacific Journal of Clinical Oncology, Adelaide, SA (2007) [E3]
2007	Ngan S, Fisher R, Mackay J, Solomon M, Burmeister B, Goldstein D, Schache D, Joseph D, Ackland Stephen, McClure B, 'Acute adverse events in a randomised trial of short course versus long course preoperative radiotherapy for T3 adenocarcinoma of rectum: a Trans-Tasman Radiation Oncology Group trial (TROG 01.04)', European Journal of Cancer Supplements, Barcelona, Spain (2007) [E3]
2007	Sobrero A, Ackland Stephen, Clarke S, Perez-Carrion R, Chiara S, Gapski J, Mainwaring P, Balcewicz M, Langer B, Young S, 'Final data from a large phase II trial of first-line bevacizurnab plus classic or modified FOLFIRI in metastatic colorectal cancer (CRC)', European Journal of Cancer Supplements, Barcelona, Spain (2007) [E3]
2007	Sobrero A, Young S, Balcewicz M, Chiara S, Perez-Carrion R, Mainwaring P, Gapski J, Clarke S, Langer B, Ackland Stephen, 'A large phase IV study of first-line bevacizumab plus irinotecan and infusional 5-FU/LV in metastatic CRC: AVIRI', Annals of Oncology, Barcelona, Spain (2007) [E3]
2006	Girgis Afaf, Boyes Allison Wendy, Clinton-Mcharg Tl, Ackland Stephen, Harnett Pr, 'Proactive, routine monitoring and intervention to reduce the psychosocial impact of cancer and its treatment in outpatient oncology services', Psycho-Oncology:Journal of the psychological, social and behavioral dimension of cancer, Ferrara-Venice, Italy (2006) [E3]
2004	Kacen L, Madjar Irena, Denham James, Ackland Stephen, Aried S, 'The patient-other dynamics of the decision to forgo or stop active treatment for cancer', Palliative Medicine, Stresa, Italy (2004) [E3]
2001	Keath R, Stewart J, Ackland Stephen, Bonaventura Anthony, 'Guidelines for the use of colony stimulating factors in patients receiving adjuvant chemotherapy for breast cancer', Proceedings in European Journal of Cancer, Unknown (2001) [E3]

The University of Newcastle, Australia