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Conjoint Prof. Stephen Ackland

Work Phone (02) 4921 1146
Fax (02) 4968 0384
Email
Office NM2, Mater Hospital Level 3 - New Med 2

Highlighted Publications

Year Citation Link
2006 Wong M, Balleine R L, Blair E Y L, McLachlan A J, Ackland Stephen, Garg M, Evans S, Farlow D, Collins M, Rivory L P, Hoskins J M, Mann G J, Clarke C L, Gurney H, 'Predictors of vinorelbine pharmacokinetics and pharmacodynamics in patients with cancer', Journal of Clinical Oncology, 24 2448-2455 (2006) [C1] Nova

Publications

For items published while at an institution other that the University of Newcastle, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Chapters In A Book (1 outputs)

Chapter in A2 Book (B2) (1 outputs)

Year Citation Link
2003 Ackland Stephen, Beale P, Godefridus Jp, 'Thymidylate synhase inhibitors', Cancer chemotherapy and Biological response modifiers, Elsevier BV, netherlands, 1-28 (2003) [B2]

Journal Articles (51 outputs)

Refereed Article in a Scholarly Journal (C1) (42 outputs)

Year Citation Link
2012 Garg M B, Lincz Lisa, Adler K, Scorgie F E, Ackland Stephen, Sakoff Jennette Anne, 'Predicting 5-Fluorouracil toxicity in colorectal cancer patients from peripheral blood cell telomere length - A multivariate analysis', British Journal of Cancer, 107 1525-1533 (2012) [C1]
2012 Ngan Samuel Y, Burmeister Bryan, Fisher Richard J, Solomon Michael, Goldstein David, Joseph David, Ackland Stephen, Schache David, McClure Bev, McLachlan Sue-Anne, McKendrick Joseph, Leong Trevor, Hartopeanu Cris, Zalcberg John, Mackay John, 'Randomized trial of short-course radiotherapy versus long-course chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: Trans-Tasman Radiation Oncology Group Trial 01.04', Journal of Clinical Oncology, 30 3827-3833 (2012) [C1]
2011 Agrez Michael, Garg Madhu, Dorahy Douglas, Ackland Stephen, 'Synergistic anti-tumor effect of cisplatin when combined with an anti-src kinase integrin-based peptide', Journal of Cancer Therapy, 2 295-301 (2011) [C1]
2011 Garg Madhu B, Ackland Stephen, 'Pyridoxine to protect from oxaliplatin-induced neurotoxicity without compromising antitumour effect', Cancer Chemotherapy and Pharmacology, 67 963-966 (2011) [C1] Nova
2011 Garg Madhu Bala, Sakoff Jennette Anne, Ackland Stephen, 'A simple HPLC method for plasma level monitoring of mitotane and its two main metabolites in adrenocortical cancer patients', Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 879 2201-2205 (2011) [C1] Nova
2011 Goldstein David, Gainford M Corona, Brown Chris, Tebbutt Niall, Ackland Stephen, Van Hazel Guy, Jefford Michael, Abdi Ehtesham, Selva-Nayagam Sid, Gebski Val, Miller Danielle, Shannon Jenny, 'Fixed-dose-rate gemcitabine combined with cisplatin in patients with inoperable biliary tract carcinomas', Cancer Chemotherapy and Pharmacology, 67 519-525 (2011) [C1] Nova
2011 Lee C K, Hudson M, Stockler M, Coates A S, Ackland Stephen, Gebski V, Lord S, Friedlander M, Boyle F, Simes R J, 'A nomogram to predict survival time in women starting first-line chemotherapy for advanced breast cancer', Breast Cancer Research and Treatment, 129 467-476 (2011) [C1]
2011 Stockler Martin R, Harvey Vernon J, Francis Prudence A, Byrne Michael J, Ackland Stephen, Fitzharris Bernie, Van Hazel Guy, Wilcken Nicholas R C, Grimison Peter S, Nowak Anna K, Gainford M Corona, Fong Akiko, Paksec Lisa Anne, Sourjina Tatiana, Zannino Diana, Gebski Val, Simes R John, Forbes John Frederick, Coates Alan S, 'Capecitabine versus classical cyclophosphamide, methotrexate, and fluorouracil as first-line chemotherapy for advanced breast cancer', Journal of Clinical Oncology, 29 4498-4504 (2011) [C1]
2010 De Bock Charles Edo, Garg Manohar Lal, Scott Naomi Marie, Sakoff Jennette Anne, Scorgie Fiona Emily, Ackland Stephen, Lincz Lisa, 'Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo', Pharmacogenomics Journal 1-8 (2010) [C1] Nova
2010 Tebbutt Niall C, Wilson Kate, Gebski Val J, Cummins Michelle M, Zannino Dianna, Van Hazel Guy A, Robinson Bridget, Broad Adam, Ganju Vinod, Ackland Stephen, Forgeson Garry, Cunningham David, Saunders Mark P, Stockler Martin R, Chua Yujo, Zalcberg John R, Simes R John, Price Timothy J, 'Capecitabine, bevacizumab, and mitomycin in first-line treatment of metastatic colorectal cancer: Results of the Australasian Gastrointestinal Trials Group Randomized Phase III MAX Study', Journal of Clinical Oncology, 28 3191-3198 (2010) [C1] Nova
2009 Ackland Stephen, Bull James M, Boyle Frances M, 'Nab-Paclitaxel: A bright new sparc in taxane therapy of cancer', Asia-Pacific Journal of Clinical Oncology, 5 147-150 (2009) [C1] Nova
2007 Davis A J, Brew S, Gebski V J, Lewis C R, Moylan E, Parnis F X, Ackland Stephen, 'Multicenter phase II study of combination chemotherapy with capecitabine and intravenous vinorelbine in patients with pretreated metastatic breast cancer', Asia-Pacific Journal of Clinical Oncology, 3 37-43 (2007) [C1]
2007 Findlay M, Sharples K, Riley G A, Simpson A, Ackland Stephen, Hall K, Isaacs R, Humm G, McKeage M J, 'Capecitabine and oral cyclophosphamide: A novel oral treatment combination for advanced cancer', Asia-Pacific Journal of Clinical Oncology, 3 99-105 (2007) [C1]
2007 Hill Timothy Adrian, Stewart Scott Gordon, Ackland Stephen, Gilbert J, Sauer Benjamin, Sakoff Jennette Anne, McCluskey Adam, 'Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation', Bioorganic and Medicinal Chemistry, 15 6126-6134 (2007) [C1] Nova
2007 Hill Timothy Adrian, Stewart Scott Gordon, Sauer Benjamin, Gilbert J, Ackland Stephen, Sakoff J A, McCluskey Adam, 'Heterocyclic substituted cantharidin and norcantharidin analogues-synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity', Bioorganic and Medicinal Chemistry Letters, 17 3392-3397 (2007) [C1] Nova
2007 Lincz Lisa, Scorgie Fiona Emily, Madhu B Garg, Ackland Stephen, 'Identification of a novel single nucleotide polymorphism in the second tandem repeat sequence of the thymidylate synthase 2R allele', International Journal of Cancer, 120 1930-1934 (2007) [C1]
2007 Stewart Scott Gordon, Hill Timothy Adrian, Gilbert Jayne, Ackland Stephen, Sakoff Jennette A, McCluskey Adam, 'Synthesis and biological evaluation of norcantharidin analogues: Towards PP1 selectivity', Bioorganic and Medicinal Chemistry, 15 7301-7310 (2007) [C1] Nova
2007 Temmink O H, Hoebe E K, Van Der Born K, Ackland Stephen, Fukushima M, Peters G J, 'Mechanism of trifluorothymidine potentiation of oxaliplatin-induced cytotoxicity to colorectal cancer cells', British Journal of Cancer, 96 231-240 (2007) [C1]
2007 Young J M, Leong D C, Armstrong K, O'Connell D, Armstrong B K, Spigelman A D, Ackland Stephen, Chapuis P, Kneebone A B, Solomon M J, 'Concordance with national guidelines for colorectal cancer care in New South Wales: a population-based patterns of care study', Medical Journal of Australia, 186 292-295 (2007) [C1]
2006 Ackland Stephen, Clarke S J, Beale P, Peters G J, 'Thymidylate synthase inhibitors', Update on Cancer Therapeutics, 1 403-427 (2006) [C1]
2006 Goldstein D, Ackland Stephen, Bell D R, Olver I N, Davis I D, Rosenthal M A, Toner G C, Pinel M C, Byrne M, 'Phase II study of vinflunine in patients with metastatic renal cell carcinoma', Investigational New Drugs, 24 429-434 (2006) [C1]
2006 Wong M, Balleine R L, Blair E Y L, McLachlan A J, Ackland Stephen, Garg M, Evans S, Farlow D, Collins M, Rivory L P, Hoskins J M, Mann G J, Clarke C L, Gurney H, 'Predictors of vinorelbine pharmacokinetics and pharmacodynamics in patients with cancer', Journal of Clinical Oncology, 24 2448-2455 (2006) [C1] Nova
2005 Ackland S P, Jones M, Tu D, Simes J, Yuen J, Sargeant A, Dhillon H, Goldberg H, Abdi E, Shepherd L, Moore M J, 'A meta-analysis of two randomised trials of early chemotherapy in asymptomatic metastatic colorectal cancer', British Journal of Cancer, 93 1236-1243 (2005) [C1]
2005 Odelli C, Burgess D, Bateman L, Hughes A, Ackland S P, Gillies J, Collins C E, 'Nutrition support improves patient outcomes, treatment tolerance and admission characteristics in oesophageal cancer', Clinical Oncology, 17 639-645 (2005) [C1]
2005 Burmeister Bryan H, Smithers B Mark, Gebski Val, Fitzgerald Lara, Simes R John, Devitt Peter, Ackland Stephen, Gotley David C, Joseph David, Millar Jeremy, North John, Walpole Evan T, Denham James, 'Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: A randomised controlled phase III trial', Lancet Oncology, 6 659-668 (2005) [C1]
2004 Liu J J, Kestell P, Findlay M, Riley G, Ackland S, Simpson A, Isaacs R, McKeage M J, 'Application of liquid chromatography-mass spectrometry to monitoring plasma cyclophosphamide levels in phase I trial cancer patients', Clinical and Experimental Pharmacology and Physiology, 31 677-682 (2004) [C1]
2004 Lincz Lisa, Scorgie Fe, Sakoff Ja, Fagan K, Ackland Stephen, Enno A, 'Telomere length predicts neutrophil recovery in absence of G-CSF after autologous peripheral blood stem cell transplantation', Bone Marrow Transplant, 34 439-445 (2004) [C1]
2004 O'Brien Mer, Wigler N, Inbar M, Rosso R, Grischke E, Santoro A, Catane R, Kieback Dg, Tomczak P, Ackland Stephen, Orlandi F, Mellars L, Alland L, Tendler C, 'Reduced cardiotoxicity and comparable efficacy in a phase 3 trial of pegylated liposomal doxorubicine HCI (CAELYX / Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer', Annals of Oncology, 15 440-449 (2004) [C1]
2004 Sakoff Jennette Anne, Howitt I J, Ackland Stephen, McCluskey Adam, 'Serine/threonine protein phosphatase inhibition enhances the effect of thymidylate synthase inhibition', Cancer Chemotherapy and Pharmacology, 53 225-232 (2004) [C1] Nova
2003 Denham James, Steigler A, Kilmurray J, Wratten Christopher, Burmeister B, Lam D, Joseph D, Delaney G, Christie David Gordon, Jamieson G G, Smithers B M, Ackland Stephen, Walpole E, 'Relapse patterns after chemo-radiation for carcinoma of the oesophagus', Clinical Oncology, 15 98-108 (2003) [C1] Nova
2003 McCluskey Adam, Ackland Stephen, Bowyer Michael Christian, Baldwin Monique Louise, Garner James Andrew, Walkom Cecilia Clare, Sakoff Jennette Anne, 'Cantharidin analogues: synthesis and evaluation of growth inhibition in a panel of selected tumour cell lines', Bioorganic Chemistry, 31 66-77 (2003) [C1] Nova
2002 Clarke S J, Abratt R, Goedhals L, Boyer M J, Milward M J, Ackland Stephen, 'Phase II trial of pemetrexed disodium (ALIMTA, LY231514) in chemotherapy-na¿ve patients with advanced non-small-cell lung cancer', Annals of Oncology, 13 737-741 (2002) [C1]
2002 Garg Madhu B, Sevester Jade C, Sakoff Jeanette A, Ackland Stephen, 'Rapid and simple chromatographic method for the determination of uracil and dihydrouracil plasma levels: A potential pretreatment predictor of 5FU toxicity', Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Science, 774 223-230 (2002) [C1]
2002 Marx G, Lewis C, Hall K, Levi J, Ackland Stephen, 'Phase I study of docetaxel plus ifosfamide in patients with advanced cancer', British Journal of Cancer, 87 846-849 (2002) [C1]
2002 Rischin D, Ackland Stephen, Smith J, Garg M B, Clarke S J, Millward M J, Toner G, Zalcberg J, 'Phase I and pharmacokinetic study of docetaxel in combination with epirubicin and cyclophosphamide in advanced cancer: dose escalation possible with G-CSF but not with prophylactic antibiotics', Annals of Oncology, 13 1810-1818 (2002) [C1]
2002 Sakoff Ja, De Waal E, Garg Mb, Denham James, Scorgie Fe, Enno A, Lincz Lisa, Ackland Stephen, 'Telomere Length in Haemopoietic Stem Cells can be Determined from that of Mononuclear Blood Cells or Whole Blood', Leukemia and Lymphoma, 43(10) 2017-2020 (2002) [C1]
2002 Talbot D C, Moiseyenko V, Van Belle S, O'Reilly S M, Alba Conejo E, Ackland Stephen, Eisenberg P, Melnychuk D, Pienkowski T, Burger H-U, Laws S, Osterwalder B, 'Randomised, phase II trial comparing oral capecitabine (Xeloda) with paclitaxel in patients with metastatic/advanced breast cancer pretreated with anthracyclines', British Journal of Cancer, 86 1367-1372 (2002) [C1]
2001 McCluskey A, Ackland S P, Gardiner E, Walkom C C, Sakoff J A, 'The inhibition of protein phosphatases 1 and 2A: A new target for rational anti-cancer drug design?', Anti-Cancer Drug Design, 16 291-303 (2001) [C1]
2001 Ackland Stephen, Anton A, Breitbach Gp, Colajori E, Tursi Jm, Delfino C, Efremedis A, Fittipaldo A, Kolaric K, Lopez M, Viaro D, Hepi 013 Study Group -, 'Dose-intensive epirubicin-based chemotherapy is superior to an intensive intravenous cyclophoshamide, methotrexate, and fluorouracil regimen in metastatic breast cancer: A randomized multinational study', Journal of Clinical Oncology, 19 943-953 (2001) [C1]
2001 McCluskey A, Walkom C, Bowyer M, Ackland Stephen, Gardiner E, Sakoff J, 'Cantharimides: A New Class of Modified Cantharidin Analogues Inhibiting Protein Phosphatases 1 and 2A', Bioorganic & Medicinal Chemistry Letters, 11 2941-2946 (2001) [C1]
2000 Garg Mb, Ackland Stephen, 'Simple and sensitive high-performance liquid chromatography method for the determination of docetaxel in human plasma or urine', Journal of Chromatography B, 748 383-388 (2000) [C1]
2000 Sakoff Ja, Ackland Stephen, 'Thymidylate synthase inhibition induces S-phase arrest, biphasic mitochondrial alterations and caspase-dependent apoptosis in leukaemia cells', Cancer Chemotherapy and Pharmacology, 46 477-487 (2000) [C1]
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Non Refereed Article in a Scholarly Journal (C2) (1 outputs)

Year Citation Link
2000 Peters Gj, De Bruin M, Fukushima M, Van Triest B, Hoekman K, Pinedo Hm, Ackland Stephen, 'Thymidine phosphorylase in angiogenesis and drug resistance', Advances in Experimental Medicine and Biology, 486 291-294 (2000) [C2]

Non Refereed Article in a Professional Journal (C3) (8 outputs)

Year Citation Link
2012 Ackland Stephen, Fukuda Yuko, '2011: Year in review - From rabbits to dragons', Asia-Pacific Journal of Clinical Oncology, 8 1-2 (2012) [C3]
2011 Ackland Stephen, 'Cancer in Australia: A model for other Asia-Pacific countries', Asia-Pacific Journal of Clinical Oncology, 7 323-324 (2011) [C3]
2011 Vilain Ricardo Enrique, Dudding Tracy Elizabeth, Braye Stephen Geoffrey, Groombridge Claire, Meldrum C, Spigelman Allan David, Ackland Stephen, Ashman Leonie Kay, Scott Rodney, 'Can a familial gastrointestinal tumour syndrome be allelic with Waardenburg syndrome?', Clinical Genetics, 79 554-560 (2011) [C3]
2009 Ackland Stephen, 'Molecular biomarkers in non-small cell lung cancer: Pointing the way to better outcomes from treatment', Asia-Pacific Journal of Clinical Oncology, 5 213-214 (2009) [C3] Nova
2008 Vilain Richard E, Ackland Stephen, 'Gastrointestinal stromal tumors - A model for understanding solid tumor biology and development of targeted therapies, or just another low-hanging fruit?', Asia-Pacific Journal of Clinical Oncology, 4 185-187 (2008) [C3]
2007 Carrington C, Carlton J, Ackland Stephen, 'Preventing chemotherapy errors: Implementing system changes', Asia-Pacific Journal of Clinical Oncology, 3 57-58 (2007) [C3]
2007 Lincz Lisa, Scorgie Fiona Emily, Garg Manohar Lal, Ackland Stephen, 'Reply to the letter to the editor 'Classification of thymidylate synthase gene enhancer region polymorphisms'', International Journal of Cancer, 121 2581-2582 (2007) [C3]
2006 Ackland Stephen, 'Cervical carcinoma: A common and preventable problem in developing countries (Editorial)', Asia-Pacific Journal of Clinical Oncology, 2 69-70 (2006) [C3]
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Conference Publication (15 outputs)

Extract of Paper (E3) (15 outputs)

Year Citation Link
2012 Goddard Emma M, Dhillon Haryana M, Turner Jane, Kabourakis Michael, Beale Philip J, Goodwin Annabel, Goldstein David, Clarke Stephen J, Ouriques Myra, Ackland Stephen, Abell Fiona, Bonaventura Antonio, Mallesara G, Fischer Clare, Kreiger Laurence, Lashbrook Marie, Vardy Janette L, 'The impact of physical activity on disease-free survival in patients with high-risk stage II or III colon cancer: One month screening results', Asia-Pacific Journal of Clinical Oncology, Brisbane (2012) [E3]
2012 Sakoff Jennette Anne, Garg Madhu Bala, Lincz Lisa, Adler K, Scorgie Fiona Emily, Ackland Stephen, 'Predicting chemotherapy-induced toxicity in cancer patients from peripheral blood telomere length', European Journal of Cancer, Barcelona, Spain (2012) [E3]
2012 Upanal Nazeerahamad Nabisaheb, Ackland Stephen, Bonaventura Anthony, McElduff Patrick, 'Improved clinical outcomes in metastatic colorectal cancer patients on first-line chemotherapy with bevacizumab can be predicted by early rise in blood pressure', Asia-Pacific Journal of Clinical Oncology, Brisbane, Queensland (2012) [E3]
2010 Ackland Stephen, 'Challenges in clinical trials design and management in the 21st century', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
2010 Garg Madhu, Sakoff Jennette Anne, Ackland Stephen, 'A simple HPLC method to measure plasma mitotane and its two main metabolites in adrenocortical cancer patients', AACR 101st Annual Meeting 2010. Abstracts, Washington, DC (2010) [E3]
2010 Sakoff Jennette Anne, Garg Madhu, Adler Kim, Scorgie Fiona Emily, Lincz Lisa, Ackland Stephen, 'Short telomeres in PBMNC predicts for haematological toxicity in colorectal cancer patients treated with 5FU', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
2010 Sakoff Jennette Anne, Garg Madhu, Adler Kim, Scorgie Fiona Emily, Lincz Lisa, Ackland Stephen, 'Telomere length in peripheral blood mononuclear cells (PBMNC) predicts for leukopenia, neutropenia and mucositis in colorectal cancer patients treated with 5FU', AACR 101st Annual Meeting 2010. Abstracts, Washington, DC (2010) [E3]
2007 Ackland Stephen, Dhillon H, Jakob L, 'The COSA and Cooperative Groups Enabling Project: What is intended to be accomplished', Asia Pacific Journal of Clinical Oncology, Adelaide, SA (2007) [E3]
2007 Ackland Stephen, Dhillon Haryana, 'Improving processes across all Cancer Cooperative Trials Groups through Standard Operating Procedures (SOPS)', Asia Pacific Journal of Clinical Oncology, Adelaide, SA (2007) [E3]
2007 Ngan S, Fisher R, Mackay J, Solomon M, Burmeister B, Goldstein D, Schache D, Joseph D, Ackland Stephen, McClure B, 'Acute adverse events in a randomised trial of short course versus long course preoperative radiotherapy for T3 adenocarcinoma of rectum: a Trans-Tasman Radiation Oncology Group trial (TROG 01.04)', European Journal of Cancer Supplements, Barcelona, Spain (2007) [E3]
2007 Sobrero A, Ackland Stephen, Clarke S, Perez-Carrion R, Chiara S, Gapski J, Mainwaring P, Balcewicz M, Langer B, Young S, 'Final data from a large phase II trial of first-line bevacizurnab plus classic or modified FOLFIRI in metastatic colorectal cancer (CRC)', European Journal of Cancer Supplements, Barcelona, Spain (2007) [E3]
2007 Sobrero A, Young S, Balcewicz M, Chiara S, Perez-Carrion R, Mainwaring P, Gapski J, Clarke S, Langer B, Ackland Stephen, 'A large phase IV study of first-line bevacizumab plus irinotecan and infusional 5-FU/LV in metastatic CRC: AVIRI', Annals of Oncology, Barcelona, Spain (2007) [E3]
2006 Girgis Afaf, Boyes Allison Wendy, Clinton-Mcharg Tl, Ackland Stephen, Harnett Pr, 'Proactive, routine monitoring and intervention to reduce the psychosocial impact of cancer and its treatment in outpatient oncology services', Psycho-Oncology:Journal of the psychological, social and behavioral dimension of cancer, Ferrara-Venice, Italy (2006) [E3]
2004 Kacen L, Madjar Irena, Denham James, Ackland Stephen, Aried S, 'The patient-other dynamics of the decision to forgo or stop active treatment for cancer', Palliative Medicine, Stresa, Italy (2004) [E3]
2001 Keath R, Stewart J, Ackland Stephen, Bonaventura Anthony, 'Guidelines for the use of colony stimulating factors in patients receiving adjuvant chemotherapy for breast cancer', Proceedings in European Journal of Cancer, Unknown (2001) [E3]
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