Dr Neil Spratt

Work Phone	(02) 4921 6171
Fax	(02) 4921 7406
Email	Neil.Spratt@newcastle.edu.au
Office	MS502a, Medical Sciences

Publications

For items published while at an institution other that the University of Newcastle, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal Articles (27 outputs)

Refereed Article in a Scholarly Journal (C1) (23 outputs)

Year	Citation	Nova
2013	Menon Bijoy K, O'Brien Billy, Bivard Andrew, Spratt Neil James, Demchuk Andrew M, Miteff Ferdinand, Lu Xuewen, Levi Christopher Royce, Parsons Mark William, 'Assessment of leptomeningeal collaterals using dynamic CT angiography in patients with acute ischemic stroke', Journal of Cerebral Blood Flow and Metabolism, 33 365-371 (2013) [C1]
2012	Parsons Mark William, Spratt Neil James, Bivard Andrew, Campbell Bruce, Chung Kong, Miteff Ferdinand, O'Brien Bill, Bladin Christopher, McElduff Patrick, Allen Chris, Bateman Grant Alexander, Donnan Geoffrey, Davis Stephen, Levi Christopher Royce, 'A randomized trial of tenecteplase versus alteplase for acute ischemic stroke', New England Journal of Medicine, 366 1099-1107 (2012) [C1]
2012	Skelding Kathryn Anne, Spratt Neil James, Fluechter Lisa, Dickson Phillip Wesley, Rostas John Andrew, 'alpha CaMKII is differentially regulated in brain regions that exhibit differing sensitivities to ischemia and excitotoxicity', Journal of Cerebral Blood Flow and Metabolism, 32 2181-2192 (2012) [C1]
2011	Bivard Andrew, McElduff Patrick, Spratt Neil James, Levi Christopher Royce, Parsons Mark William, 'Defining the extent of irreversible brain ischemia using perfusion computed tomography', Cerebrovascular Diseases, 31 238-245 (2011) [C1]
2011	Bivard Andrew, Spratt Neil James, Levi Christopher Royce, Parsons Mark William, 'Acute stroke thrombolysis: Time to dispense with the clock and move to tissue-based decision making?', Expert Review of Cardiovascular Therapy, 9 451-461 (2011) [C1]
2011	Bivard Andrew, Spratt Neil James, Levi Christopher Royce, Parsons Mark William, 'Perfusion computer tomography: Imaging and clinical validation in acute ischaemic stroke', Brain, 134 3408-3416 (2011) [C1]
2011	McLeod Damian Donald, Parsons Mark William, Levi Christopher Royce, Beautement Stephen, Buxton David, Roworth Brett, Spratt Neil James, 'Establishing a rodent stroke perfusion CT model', International Journal of Stroke, 6 284-289 (2011) [C1]
2011	Spratt Neil James, Donnan Geoffrey A, McLeod Damian Donald, Howells David W, ''Salvaged' stroke ischaemic penumbra shows significant injury: Studies with the hypoxia tracer FMISO', Journal of Cerebral Blood Flow and Metabolism, 31 934-943 (2011) [C1]
2010	Garnett Ashley R, Marsden Dianne L, Parsons Mark William, Quain Debbie Anne, Spratt Neil James, Loudfoot Allan R, Middleton Paul M, Levi Christopher Royce, 'The rural Prehospital Acute Stroke Triage (PAST) trial protocol: A controlled trial for rapid facilitated transport of rural acute stroke patients to a regional stroke centre', International Journal of Stroke, 5 506-513 (2010) [C1]
2010	Janssen Heidi, Bernhardt Julie, Collier Janice M, Sena Emily S, McElduff Patrick, Attia John Richard, Pollack Michael Ronald, Howells David W, Nilsson Michael, Calford Michael Brian, Spratt Neil James, 'An enriched environment improves sensorimotor function post-ischemic stroke', Neurorehabilitation and Neural Repair, 24 802-813 (2010) [C1]
2010	Marsden Dianne L, Spratt Neil James, Walker Rhonda, Barker Daniel Jacob, Attia John Richard, Pollack Michael Ronald, Parsons Mark William, Levi Christopher Royce, 'Trends in stroke attack rates and case fatality in the Hunter Region, Australia 1996-2008', Cerebrovascular Diseases, 30 500-507 (2010) [C1]
2009	SPRATT N J, DONNAN G A, HOWELLS D W, 'Characterisation of the timing of binding of the hypoxia tracer FMISO after stroke', Brain Research, 1288 135-142 (2009) [C1]
2009	Miteff Ferdinand, Levi Christopher Royce, Bateman Grant A, Spratt Neil James, McElduff Patrick, Parsons Mark William, 'The independent predictive utility of computed tomography angiographic collateral status in acute ischaemic stroke', Brain, 132 2231-2238 (2009) [C1]
2009	Parsons Mark William, Miteff Ferdinand, Bateman Grant Alexander, Spratt Neil James, Loiselle A, Attia John Richard, Levi Christopher Royce, 'Acute ischemic stroke imaging-guided tenecteplase treatment in an extended time window', Neurology, 72 915-921 (2009) [C1]
2008	SCOPE COLLABORATIONS S O, IST, LEVI C, PARSONS M, SPRATT N, EVANS M, ROYAN A, 'Predicting outcome in hyper-acute stroke: validation of a prognostic model in the Third International Stroke Trial (IST3)', Journal of Neurology Neurosurgery and Psychiatry, 79 397-400 (2008) [C1]
2008	Quain Debbie Anne, Parsons Mark William, Loudfoot Allan R, Spratt Neil James, Evans Malcolm K, Russell Michelle L, Royan Angela T, Moore Andrea G, Miteff Ferdinand, Hullick Carolyn J, Attia John Richard, McElduff Patrick, Levi Christopher Royce, 'Improving access to acute stroke therapies: A controlled trial of organised pre-hospital and emergency care', Medical Journal of Australia, 189 429-433 (2008) [C1]
2006	FALZON C L, ACKERMANN U, SPRATT N, TOCHON-DANGUY H J, WHITE J, HOWELLS D, SCOTT A M, 'F-18 labelled N, N-bis-haloethylamino-phenylsulfoxides - a new class of compounds for the imaging of hypoxic tissue', Journal of Labelled Compounds and Radiopharmaceuticals, 49 1089-1103 (2006) [C1]
2006	SPRATT N, ACKERMAN U, TOCHON-DANGUY H J, DONNAN G A, HOWELLS D W, 'Characterization of fluoromisonidazole binding in stroke', Stroke, 37 1862-1867 (2006) [C1]
2006	SPRATT N, FERNANDEZ J, CHEN M, REWELL S, COX S, VAN RAAY L, HOGAN L, HOWELLS D W, 'Modification of the method of thread manufacture improves stroke induction rate and reduces mortality after thread-occlusion of the middle cerebral artery in young or aged rats', Journal of Neuroscience Methods, 155 285-290 (2006) [C1]
2004	SAITA K, CHEN M, SPRATT N, PORRITT M J, LIBERATORE G T, READ S J, LEVI C J, DONNAN G A, ACKERMANN U, TOCHON-DANGUY H J, SACHINIDIS J I, HOWELLS D W, 'Imaging the ischemic penumbra with 18F-fluoromisonidazole in a rat model of ischemic stroke', Stroke, 35 975-980 (2004) [C1]
2003	SPRATT N, HOWELLS D W, 'Ischaemic tolerance and mitochondrial uncoupling - can we learn from the cell', Cerebrovascular Diseases, 19 206-208 (2003) [C1]
2003	SPRATT N, WANG Y, LEVI C, NG K, EVANS M, FISHER J D, 'A prospective study of predictors of prolonged hospital stay and disability after stroke', Journal of Clinical Neuroscience, 10 665-669 (2003) [C1]
2003	WANG Y, LEVI C R, JOHN A, D'ESTE C, SPRATT N, FISHER J, 'Seasonal variation of stroke in the Hunter Region, Australia. A five-year hospital-based study', Stroke, 34 1144-1150 (2003) [C1]

Non Refereed Article in a Professional Journal (C3) (3 outputs)

Year	Citation	Nova
2012	Janssen Heidi, Ada L, Karayanidis Frini, Drysdale Karen, McElduff Patrick, Pollack Michael Ronald, White Jennifer Helen, Nilsson Michael, Bernhardt J, Spratt Neil James, 'Translating the use of an enriched environment poststroke from bench to bedside: study design and protocol used to test the feasibility of environmental enrichment on stroke patients in rehabilitation', International Journal of Stroke, 7 521-526 (2012) [C3]
2010	Abed Hany, Barlow Malcolm Andrew, Wellings Thomas Peter, Spratt Neil James, Collins Nicholas, 'Cardiogenic shock complicating subarachnoid haemorrhage diagnosed as Tako Tsubo Cardiomyopathy: A cautionary tale', Heart Lung and Circulation, 19 476-479 (2010) [C3]
2010	Spratt Neil James, 'Where next for stroke?', The Lancet Neurology, 9 660 (2010) [C3]

Other Refereed Contribution to a Scholarly Journal (C5) (1 outputs)

Year	Citation	Nova
2009	LEVI C, PARSONS M, SPRATT N, EVANS M, ROYAN A, 'Predicting Outcome in hyper-acute stroke: validation of a prognostic model in the Thir', Journal of Neurology, Neurosurgery and Psychiatry, 79 397-400 (2009) [C5]

Conference Publication (48 outputs)

Full Written Paper - Refereed (E1) (1 outputs)

Year	Citation	Nova
2005	FALZON C F, SPRATT N, ACKERMANN U, WHITE J M, TOCHON-DANGUY H J, HOWLELLS D, O'KEEFE G J, 'A New Method for Thread Occlusion of the Middle Cerebral Artery Permits Induction of Stroke in Old Hypertensive and Diabetic Rats with Improved Reproducibility and Reduced Mortality', Internal Medicine Journal, Hobart, Tasmania, Australia (2005) [E1]

Extract of Paper (E3) (47 outputs)

Year	Citation	Nova
2012	Alborough K, White Jennifer Helen, Janssen Heidi, Spratt Neil James, Jordan L, Pollack Michael Ronald, 'Exploring staff experience of an 'Enriched Environment' within stroke rehabilitation: A qualitative sub-study', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
2012	Arulampalam A, McLeod Damian Donald, Spratt Neil James, 'Fluid shifts in the rat brain after ischaemic stroke', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
2012	Bartley E, White Jennifer Helen, Janssen Heidi, Spratt Neil James, Pollack M, 'Exploring the experience of stroke rehabilitation following exposure to an enriched environment', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
2012	Beard Daniel Joseph, McLeod Damian Donald, Imtiaz Mohammad Sahariq, Spratt Neil James, 'Quantitative assessment of leptomeningeal collateral flow in experimental stroke', The Stroke Interventionalist, Los Angeles, CA (2012) [E3]
2012	Bernhardt J, Janssen Heidi, Ada L, McElduff Patrick, Pollack M, Spratt Neil James, 'Exposure to an enriched environment increases post stroke activity and decreases time spent alone', Abstract E-book. 2012 European Stroke Conference, Lisbon, Portugal (2012) [E3]
2012	Dunn A, Marsden D L, Spratt Neil James, Levi Christopher Royce, Callister Robin, 'Does knee strength affect walking speed, distance and fitness levels following stroke? Preliminary results from the 'How Fit is the Stroke Survivor?' (HowFITSS?) trial', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
2012	Garnett A R, Marsden D L, Parsons Mark William, Spratt Neil James, Watson T, Loudfoot A R, McElduff Patrick, Levi Christopher Royce, 'The Hunter Rural PAST Protocol: An innovative and effective partnership between ambulance and a regional thrombolysis centre to facilitate access for rural stroke patient to thrombolysis', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
2012	Marsden D L, Callister Robin, Dunn A, Levi Christopher Royce, Spratt Neil James, 'How fit is the stroke survivor? Assessing the fitness levels of stroke survivors by comparing four methods available in the clinical setting. The 'HowFITSS' Trial', Abstract E-book. 2012 European Stroke Conference, Lisbon, Portugal (2012) [E3]
2012	Marsden D L, Dunn A, Callister Robin, Levi Christopher Royce, Spratt Neil James, 'Assessing stroke survivors' cardiorespiratory fitness - A comparison of four methods available in the clinical setting: Preliminary results from the 'How Fit is the Stroke Survivor?' (HowFITSS?) trial', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
2012	Marsden D L, Dunn A, Callister Robin, Levi Christopher Royce, Spratt Neil James, 'Measuring cardiorespiratory fitness and oxygen consumption after stroke - A Systematic Review', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
2012	Marsden D L, Garnett A R, Parsons Mark William, Spratt Neil James, Watson T, Loudfoot A, McElduff Patrick, Levi Christopher Royce, 'No thrombolysis service? No worries. A controlled trial of facilitated access for rural stroke patients to a regional thrombolysis centre - The Hunter Rural PAST Protocol', Abstract E-book. 2012 European Stroke Conference, Lisbon, Portugal (2012) [E3]
2012	McLeod Damian Donald, Beard Daniel Joseph, Imtiaz Mohammad Sahariq, Spratt Neil James, 'Validating a novel method for measuring leptomeningeal collateral flow in experimental stroke', The Stroke Interventionalist, Los Angeles, CA (2012) [E3]
2012	Murtha Lucy Anne, McLeod Damian Donald, Spratt Neil James, 'The effects of therapeutic hypothermia on intracranial pressure after experimental ischemic stroke', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
2012	Rostas John Andrew, Skelding Kathryn Anne, Fluechter Lisa, Dickson Phillip Wesley, Spratt Neil James, 'CaMKII is differentially regulated in striatum and cortex', Journal of Molecular Neuroscience: Abstracts The 21st Annual Meeting of the Israel Society for Neuroscience & The First Binational Australian-Israeli Meeting in Neuroscience, Eilat, Israel (2012) [E3]
2012	Skelding Kathryn Anne, Abdul Majeed A'Qilah Banu Binte, Dickson Phillip Wesley, Spratt Neil James, Rostas John Andrew, 'CAMKII is regulated differently in brains regions with differing sensitivities to ischaemia/excitotoxicity', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
2011	Bivard Andrew, Levi Christopher Royce, Spratt Neil James, Parsons Mark William, 'Delayed perfusion predicts the volume of the perfusion lesion', Stroke, Los Angeles, CA (2011) [E3]
2011	Bivard Andrew, Spratt Neil James, Levi Christopher Royce, Parsons Mark William, 'CTP thresholds to detect acute ischeamic stroke tissue pathophysiology', International Journal of Stroke, Adelaide, SA (2011) [E3]
2011	Bivard Andrew, Spratt Neil James, Levi Christopher Royce, Parsons Mark William, 'Perfusion CT predicts subsequent tissue and clinical outcome in hyperacute ischemic stroke', Cerebrovascular Diseases, Hamburg, Germany (2011) [E3]
2011	Janssen Heidi, Ada Louise, Bernhardt Julie, McElduff Patrick, Pollack Michael Ronald, Spratt Neil James, 'Levels of physical, cognitive and social activity are low and stable during a two week period of stroke rehabilitation', APA Physiotherapy Conference 2011 Abstract Presentations, Brisbane (2011) [E3]
2011	Lillicrap T, Jyoti R, Levi Christopher Royce, Parsons Mark William, Spratt Neil James, Stanwell P, Lueck C, 'Temperature measurements using MR spectroscopy: Validation and calibration in healthy volunteers', International Journal of Stroke, Adelaide, SA (2011) [E3]
2011	Menon B K, O'Brien W, Bivard Andrew, Levi Christopher Royce, Spratt Neil James, Parsons Mark William, 'Anatomic and physiologic assessment of leptomeningeal collaterals in acute ischemic stroke patients using dynamic time resolved 320 slice CT angiography', Stroke, Ottawa, Canada (2011) [E3]
2011	Menon B, O'Brien W, Bivard Andrew, Levi Christopher Royce, Spratt Neil James, Parsons Mark William, 'Detailed anatomic and physiologic assessment of leptomeningeal collaterals in acute ischemic stroke patients using dynamic time resolved 320 slice CT angiography', International Journal of Stroke, Adelaide, SA (2011) [E3]
2011	Murtha Lucy Anne, McLeod Damian Donald, McCann Sarah, Pepperall Debbie-Gai, Spratt Neil James, 'Short duration hypothermia results in sustained prevention of intracranial pressure elevation following experimental stroke', International Journal of Stroke, Adelaide, SA (2011) [E3]
2011	O'Brien W, Chung K, Levi Christopher Royce, Spratt Neil James, Parsons Mark William, 'Comparative study of Multimodal Computed Tomography (MdCT) and Magnetic resonance imaging (MRI) in Transient ischaemic attack and minor stroke patient', International Journal of Stroke, Adelaide, SA (2011) [E3]
2011	Russell Michelle Louise, Evans Malcolm Kim, Royan Angela Therese, Magin Parker John, Lasserson D, Attia John Richard, McElduff Patrick, Spratt Neil James, Parsons Mark William, Levi Christopher Royce, 'Referral and triage of patients with TIAs to an acute access clinic: Risk-stratification performance in an Australian setting', International Journal of Stroke, Adelaide, SA (2011) [E3]
2011	Shiue I, Marsden D L, Spratt Neil James, Matzarakis A, McElduff Patrick, Anderson C S, Levi Christopher Royce, 'Psychologically equivalent temperature and stroke attack rates', Cerebrovascular Diseases, Hamburg, Germany (2011) [E3]
2011	Skelding Kathryn Anne, Chung S, Pepperall Debbie-Gai, Tomkins Amelia Jane, Spratt Neil James, Rostas John Andrew, 'The role of CaMKII in neuronal sensitivity to ischaemia', Oral abstracts. Australian Neuroscience Society Annual Meeting, Auckland, NZ (2011) [E3]
2011	Tomkins Amelia Jane, Chung S, Pepperall Debbie-Gai, Beard D, Calford Michael Brian, Spratt Neil James, 'Distribution and quantification of the neurosteroid allopregnanolone in response to stroke', Oral abstracts. Australian Neuroscience Society Annual Meeting, Auckland, NZ (2011) [E3]
2010	Bivard Andrew, McElduff Patrick, Levi Christopher Royce, Spratt Neil James, Parsons Mark William, 'Defining the extent of irreversible brain ischemia using perfusion computed tomography', Stroke, San Antonio, Texas (2010) [E3]
2010	Bivard Andrew, McElduff Patrick, Spratt Neil James, Levi Christopher Royce, Parsons Mark William, 'Validating perfusion-computed tomography in defining extent of irreversible brain ischemia', Circulation, Beijing (2010) [E3]
2010	Lillicrap Thomas P, Hudson Steven, Stanwell Peter, Parsons Mark William, Spratt Neil James, Levi Christopher Royce, 'MR spectroscopy and diffusion-weighted MRI can accurately measure both reduced and increased brain temperature', Stroke, San Antonio, Texas (2010) [E3]
2010	Lillicrap Thomas, Stanwell Peter, Parsons Mark William, Spratt Neil James, Hudson Steven, Levi Christopher Royce, 'MR spectroscopy in brain temperature measurement and application to induced hypothermia therapy', Circulation, Beijing (2010) [E3]
2010	Skelding Kathryn Anne, Tomkins Amelia Jane, Fluechter Lisa, Pepperall Debbie-Gai, Spratt Neil James, Rostas John Andrew, 'Ischaemia-induced CaMKII phosphorylation in hypertensive and normotensive rats', Proceding of the Australian Neuroscience Society, Sydney, NSW (2010) [E3]
2009	McLeod Damian Donald, Parsons Mark William, Levi Christopher Royce, Beautement S, Roworth B, Buxton D, Abel C, Calford Michael Brian, Spratt Neil James, 'An experimental model to investigate CT brain perfusion after stroke', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
2009	McLeod Damian Donald, Spratt Neil James, Levi Christopher Royce, Beautement S, Roworth B, Buxton D, Abel C, Calford Michael Brian, Parsons Mark William, 'Experimental validation of perfusion computed tomography in acute middle cerebral artery occlusion', ACBRC 2009 Abstracts, Tianjin, China (2009) [E3]
2009	McLeod Damian Donald, Spratt Neil James, Levi Christopher Royce, Beautement S, Roworth B, Buxton D, Abel C, Calford Michael Brian, Parsons Mark William, 'Perfusion computed tomography for acute stroke: A model for experimental validation', Cerebrovascular Diseases, Stockholm, Sweden (2009) [E3]
2009	Tomkins Amelia Jane, Rostas John Andrew, Pepperall Debbie-Gai, Calford Michael Brian, Spratt Neil James, 'Infarction occurs more rapidly in hypertensive rats', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
2008	SPRATT N, DONNAN G, HOWELLS D, 'Specificity of fluoromisonidazole for hypoxia in stroke', Journal of Neurological Sciences, Sydney Australia (2008) [E3]
2008	Janssen Heidi, Collier Janice, Bernhardt Julie, Pollack Michael Ronald, Sena Emily, Spratt Neil James, 'Gathering the evidence: The use of an enriched environment post stroke', Internal Medicine Journal, Sydney, NSW (2008) [E3]
2008	Miteff F, Parsons Mark William, Bateman G A, Spratt Neil James, Levi Christopher Royce, 'Does collateral vessel status on CT angiography add to perfusion CT in the prediction of outcome after acute ischaemc stroke?', Internal Medicine Journal, Sydney, NSW (2008) [E3]
2008	Pepperall Debbie-Gai, Tomkins Amelia Jane, Calford Michael Brian, Spratt Neil James, 'The effectiveness of neurological tests of somatosensory function following stroke in rats', Internal Medicine Journal, Sydney, NSW (2008) [E3]
2008	Spratt Neil James, 'Locating the target, and identifying mechanisms and therapies for neuroprotection in stroke', Journal of Neurochemistry, Shanghai, China (2008) [E3]
2008	Tomkins Amelia Jane, Pepperall Debbie-Gai, Calford Michael Brian, Spratt Neil James, 'Investigation of the putative neuroprotectant effect of the neurosteroid allopregnanolone after stroke', Internal Medicine Journal, Sydney, NSW (2008) [E3]
2005	SPRATT N J, FERNANDEZ J A, CHEN M, REWELL S S, COX S F, RAAY L, HOGAN L, HOWELLS D W, 'An Improved Technique for Silicone-Coating the Suture Used in Rat MCA Occlusion Increases Stroke Induction Rate, Reduces Mortality, and Is Effective across a Wide Weight and Age Range', Journal of Cerebral Blood Flow & Metabolism, - (2005) [E3]
2005	SPRATT N, SAITA K, CHEN M, HOWELLS D, DONNAN G A, ACKERMANN U, TOCHON-DANGUY H J, SACHINIDIS J I, 'FMISO for investigating the ischaemic penumbra in stroke', Journal of Clinical Neuroscience, Miami Beach, Florida, USA (2005) [E3]
2004	SAITA K, CHEN M, SPRATT N J, PORRITT M J, LIBERATORE G T, ACKERMANN U, TOUCHON-DANGUY H J, SACHINIDIS J I, DONNAN G A, HOWELLS D W, 'Modelling the ischaemic penumbra in a rat model of stroke', Internal Medicine Journal, Sydney Australia (2004) [E3]
2003	SPRATT N J, BLACKIE J D, RUDDELL T, 'An unusual case of "optic neuritis"', Journal of Clinical Neuroscience, Honolulu, Hawaii (2003) [E3]

The University of Newcastle, Australia