Conjoint Prof. Leonie Ashman

Work Phone	(08) 8376 9069
Fax	-
Email	Leonie.Ashman@newcastle.edu.au
Office	-, -

Highlighted Publications

Year	Citation	Nova
2006	Cowin A J, Adams D, Geary Sean Michael, Wright M D, Jones J C R, Ashman Leonie Kay, 'Wound healing is defective in mice lacking tetraspanin CD151', Journal of Investigative Dermatology, 126 680-689 (2006) [C1]
2004	Wright Mark D, Geary Sean Michael, Fitter John Thomas, Moseley Gregory W, Lau Lai-Man, Sheng Kuo-Ching, Apostolopoulos Vasso, Stanley Edouard G, Jackson Denise E, Ashman Leonie Kay, 'Characterization of Mice Lacking the Tetraspanin Superfamily Member CD151', Molecular and Cellular Biology, 24 5978-5988 (2004) [C1]
2003	Ferrao Petranel Theresa, Frost Michelle June, Siah Shoo Peng, Ashman Leonie Kay, 'Overexpression of P-glycoprotein in K562 cells does not confer resistance to the growth inhibitory effects of imatinib (STI571) in vitro', Blood, 102 4499-4503 (2003) [C1]
2002	Frost Michelle June, Ferrao Petranel Theresa, Hughes Tp, Ashman Leonie Kay, 'Juxtamembrane Mutant V560GKit Is more Sensitive to Imatinib (ST1571) Compared with Wild-Type c-Kit Whereas the Kinase Domain Mutant D816VKit is Resistant', Molecular Cancer Therapeutics, 1 1115-1124 (2002) [C1]

Publications

For items published while at an institution other that the University of Newcastle, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal Articles (41 outputs)

Refereed Article in a Scholarly Journal (C1) (38 outputs)

Year	Citation	Nova
2010	Ang Jian, Fang Bing-Liang, Ashman Leonie Kay, Frauman Albert G, 'The migration and invasion of human prostate cancer cell lines involves CD151 expression', Oncology Reports, 24 1593-1597 (2010) [C1]
2010	Mashkani Baratali, Griffith Renate, Ashman Leonie Kay, 'Colony stimulating factor-1 receptor as a target for small molecule inhibitors', Bioorganic & Medicinal Chemistry, 18 1789-1797 (2010) [C1]
2010	Roberts Kathryn Grace, Smith Amanda Melanie, McDougall Fiona Karen, Carpenter Helen Christine, Horan Martin Patrick, Neviani Paolo, Powell Jason A, Thomas Daniel, Guthridge Mark A, Perrotti Danilo, Sim Alistair Thomas, Ashman Leonie Kay, Verrills Nicole Margaret, 'Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers', Cancer Research, 70 5438-5447 (2010) [C1]
2009	Orlowski E, Chand R, Yip J, Wong C, Goschnick M W, Wright M D, Ashman Leonie Kay, Jackson D E, 'A platelet tetraspanin superfamily member, CD151, is required for regulation of thrombus growth and stability in vivo', Journal of Thrombosis and Haemostasis, 7 2074-2084 (2009) [C1]
2009	Protty Majd B, Watkins Nicholas A, Colombo Dario, Thomas Steven G, Heath Victoria L, Herbert John M J, Bicknell Roy, Senis Yotis A, Ashman Leonie Kay, Berditchevski Fedor, Ouwehand Willem H, Watson Steve P, Tomlinson Michael G, 'Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains', Biochemical Journal, 417 391-400 (2009) [C1]
2009	Sheng Kuo-Ching, Van Spriel Annemiek B, Gartlan Kate H, Sofi Mariam, Apostolopoulos Vasso, Ashman Leonie Kay, Wright Mark D, 'Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC', European Journal of Immunology, 39 50-55 (2009) [C1]
2009	Weidenhofer Judith Clare, Ashman Leonie Kay, 'CD151 (CD151 molecule (Raph blood group))', Atlas of Genetics and Cytogenetics in Oncology and Haematology, - - (2009) [C1]
2008	Baldwin Gouri, Novitskaya Vera, Sadej Rafal, Pochec Ewa, Litynska Anna, Hartmann Christoph, Williams Janelle, Ashman Leonie Kay, Eble Johannes A, Berditchevski Fedor, 'Tetraspanin CD151 regulates glycosylation of alpha 3 beta 1 integrin', Journal of Biological Chemistry, 283 35445-35454 (2008) [C1]
2008	Baleato Rosa, Guthrie Petrina Louise, Gubler Marie-Claire, Ashman Leonie Kay, Roselli Severine Melanie, 'Deletion of Cd151 results in a strain-dependent glomerular disease due to severe alterations of the glomerular basement membrane', American Journal of Pathology, 173 927-937 (2008) [C1]
2008	Foster Rowan Clare, Byrnes Ellen Maree, Meldrum C, Griffith Renate, Ross G, Upjohn E, Braue A, Scott Rodney, Varigos G, Ferrao Petranel Theresa, Ashman Leonie Kay, 'Association of paediatric mastocytosis with a polymorphism resulting in an amino acid substitution (M541L) in the transmembrane domain of c-KIT', British Journal of Dermatology, 159 1160-1169 (2008) [C1]
2008	Geary Sean Michael, Cowin Allison J, Copeland Ben Troy, Baleato Rosa, Miyazaki Kaoru, Ashman Leonie Kay, 'The role of the tetraspanin CD151 in primary keratinocyte and fibroblast functions: Implications for wound healing', Experimental Cell Research, 314 2165-2175 (2008) [C1]
2008	Yamada Masashi, Tamura Yumiko, Sanzen Noriko, Sato-Nishiuchi Ryoko, Hasegawa Hitoshi, Ashman Leonie Kay, Rubinstein Eric, Yanez-Mo Maria, Sanchez-Madrid Francisco, Sekiguchi Kiyotoshi, 'Probing the interaction of tetraspanin CD151 with integrin alpha 3 beta 1 using a panel of monoclonal antibodies with distinct reactivities toward the CD151-integrin alpha 3 beta 1 complex', Biochemical Journal, 415 417-427 (2008) [C1]
2007	Roberts Kathryn Grace, Odell Adam Francis, Byrnes Ellen Maree, Baleato Rosa, Griffith Renate, Lyons A B, Ashman Leonie Kay, 'Resistance to c-KIT kinase inhibitors conferred by V654A mutation', Molecular Cancer Therapeutics, 6 1159-1166 (2007) [C1]
2007	Young Sonia Marie, Cambareri A C, Odell Adam Francis, Geary Sean Michael, Ashman Leonie Kay, 'Early myeloid cells expressing c-KIT isoforms differ in signal transduction, survival and chemotactic responses to Stem Cell Factor', Cellular Signalling, 19 2572-2581 (2007) [C1]
2006	Cowin A J, Adams D, Geary Sean Michael, Wright M D, Jones J C R, Ashman Leonie Kay, 'Wound healing is defective in mice lacking tetraspanin CD151', Journal of Investigative Dermatology, 126 680-689 (2006) [C1]
2006	Griffith Renate, Brown Michael Nicholas, McCluskey Adam, Ashman Leonie Kay, 'Small molecule inhibitors of protein kinases in cancer - How to overcome resistance', Mini-Reviews in Medicinal Chemistry, 6 1101-1110 (2006) [C1]
2006	Winterwood N E, Varzavand A, Meland M N, Ashman Leonie Kay, Stipp C S, 'A critical role for tetraspanin CD151 in alpha 381 and alpha 684 integrin-dependent tumor cell functions on Laminin-5', Molecular Biology of the Cell, 17 2707-2721 (2006) [C1]
2006	Young Sonia Marie, Cambareri A C, Ashman Leonie Kay, 'Role of c-KIT expression level and phosphatidylinositol 3-kinase activation in survival and proliferative responses of early myeloid cells', Cellular Signalling, 18 608-620 (2006) [C1]
2005	Cullinane C, Dorow D S, Kansara M, Conus N, Binns D, Hicks R J, Ashman Leonie Kay, McArthur G A, Thomas D M, 'An in vivo tumor model exploiting metabolic response as a biomarker for targeted drug development', Cancer Research, 65 9633-9636 (2005) [C1]
2005	Gesierich S, Paret C, Hildebrand D, Weitz J, Zgraggen K, Schmitz-Winnenthal F H, Horejsi V, Yoshie O, Herlyn D, Ashman Leonie Kay, Zoller M, 'Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: Impact on cell motility', Clinical Cancer Research, 11 2840-2852 (2005) [C1]
2005	Nixon Brett, Paul Jonathan Winter, Spiller Cassy M, Attwell-Heap Abigail Georgina, Ashman Leonie Kay, Aitken Robert John, 'Evidence for the involvement of PECAM-1 in a receptor mediated signal-transduction pathway regulating capacitation-associated tyrosine phosphorylation in human spermatozoa', Journal of Cell Science, 118 4865-4877 (2005) [C1]
2004	Ang Jian, Lijovic Marijana, Ashman Leonie Kay, Kan Kathleen, Frauman Albert, 'CD151 Protein Expression Predicts the Clinical Outcome of Low-Grade Primary Prostate Cancer Better than Histologic Grading: A New Prognostic Indicator?', Cancer Epidemiology, Biomarkers & Prevention, 13 1717-1721 (2004) [C1]
2004	Foster Rowan Clare, Griffith Renate, Ferrao Petranel Theresa, Ashman Leonie Kay, 'Molecular basis of the constitutive activity and STI571 resistance of Asp816Val mutant KIT receptor tyrosine kinase', Journal of Molecular Graphics and Modelling, 23 139-152 (2004) [C1]
2004	Lau Lai-Man, Wee Janet L, Wright Mark D, Moseley Gregory W, Hogarth P Mark, Ashman Leonie Kay, Jackson Denise E, 'The tetraspanin superfamily member CD151 regulates outside-in integrin alpha IIb Beta 3 signaling and platelet function', Blood, 104 2368-2375 (2004) [C1]
2004	Wright Mark D, Geary Sean Michael, Fitter John Thomas, Moseley Gregory W, Lau Lai-Man, Sheng Kuo-Ching, Apostolopoulos Vasso, Stanley Edouard G, Jackson Denise E, Ashman Leonie Kay, 'Characterization of Mice Lacking the Tetraspanin Superfamily Member CD151', Molecular and Cellular Biology, 24 5978-5988 (2004) [C1]
2003	TO L B, BASHFORD J, DURRANT S, MACMILLAN J, SCHWARER A P, PRINCE H M, GIBSON J, LEWIS I, SWART B, MARTY J, RAWLING T, ASHMAN L, CHARLES S, COHEN B, 'Successful mobilisation of peripheral blood stem cell after addition of ancestim (stem cell factor) in patients who had failed a prior mobilisation with filgrastim (granulocyte colony stimulating factor) alone or with chemotherapy plus filgrastim', Bone Marrow Transplantation, 31 371-378 (2003) [C1]
2003	Charrin Stephanie, Manie Serge, Billard Martine, Ashman Leonie Kay, Gerlier Denis, Boucheix Claude, Rubinstein Eric, 'Multiple levels of interactions within the tetraspanin web', Biochemical and Biophysical Research Communications, 304 107-112 (2003) [C1]
2003	Chattopadhyay Nibedita, Wang Zemin, Ashman Leonie Kay, Brady-Kalnay Susann M, Kreidberg Jordan A, 'Alpha3 beta1 integrin-CD151, a component of the cadherin-catenin complex, regulates PTPu expression and cell-cell adhesion', The Journal of Cell Biology, 163 1351-1362 (2003) [C1]
2003	Ferrao Petranel Theresa, Frost Michelle June, Siah Shoo Peng, Ashman Leonie Kay, 'Overexpression of P-glycoprotein in K562 cells does not confer resistance to the growth inhibitory effects of imatinib (STI571) in vitro', Blood, 102 4499-4503 (2003) [C1]
2003	Ferrao Petranel Theresa, Gonda Thomas, Ashman Leonie Kay, 'Constitutively active mutant D816VKit induces megakayocyte and mast cell differentiation of early haemopoietic cells from murine foetal liver', Leukemia Research, 27 547-555 (2003) [C1]
2003	Thai Le M, Ashman Leonie Kay, Harbour Stacey N, Hogarth Mark, Jackson Denise, 'Physical proximity and functional interplay of PECAM-1 with the Fc receptor FcyRIIa on the platelet plasma membrane', Blood, 102 3637-3645 (2003) [C1]
2003	Voytyuk Olexandra, Lennartsson Johan, Mogi Akira, Caruana Georgina, Courtneidge Sara, Ashman Leonie Kay, Ronnstrand Lars, 'Src Family Kinases Are Involved in the Differential Signaling from Two Splice Forms of c-Kit', The Journal of Biological Chemistry, 278 9159-9166 (2003) [C1]
2002	Ashman Leonie Kay, 'CD151', Journal of Biological Regulators and Homeostatic Agents, 16 223-6 (2002) [C1]
2002	Farah C S, Elahi Shokrollah, Drysdale K, Pang Gerald Toh, Gotjamanos T, Seymour G J, Clancy Robert Llewellyn, Ashman Leonie Kay, 'Primary Role for CD4+ T Lymphocytes in Recovery from Oropharyngeal Candidiasis', Infection and Immunity, 70 724-731 (2002) [C1]
2002	Frost Michelle June, Ferrao Petranel Theresa, Hughes Tp, Ashman Leonie Kay, 'Juxtamembrane Mutant V560GKit Is more Sensitive to Imatinib (ST1571) Compared with Wild-Type c-Kit Whereas the Kinase Domain Mutant D816VKit is Resistant', Molecular Cancer Therapeutics, 1 1115-1124 (2002) [C1]
2001	Berditchevksi F, Gilbert E, Griffiths M R, Fitter S, Ashman L, Jenner S J, 'Analysis of the CD151-a3b1 integrin and CD151-tetraspanin interactions by mutagenesis 41165-41174 (2001) [C1]
2001	Chian R, Young S M, Danilkovitch-Miagkova A, Ronnstrand L, Leonard E, Ferrao P, Ashman L, Linnekin D, 'PI3-kinase mediates transformation of hematopoietic cells by the V816 c-Kit mutant', Blood, 98 1365-1373 (2001) [C1]
2001	Geary S M, Cambaren A C, Fitter S, Ashman L K, 'Differential tissue expression of epitopes of the tetraspanin CD151 recognised by monoclonal antibodies', Tissue Antigens, 58 142-153 (2001) [C1]

Non Refereed Article in a Professional Journal (C3) (2 outputs)

Year	Citation	Nova
2011	Ashman Leonie Kay, 'Cell line models identify different sensitivity of mutant forms of c-KIT to kinase inhibitory drugs and predict the response of patients to therapy', Molecular Cancer Therapeutics, 10 2032-2033 (2011) [C3]
2011	Vilain Ricardo Enrique, Dudding Tracy Elizabeth, Braye Stephen Geoffrey, Groombridge Claire, Meldrum C, Spigelman Allan David, Ackland Stephen, Ashman Leonie Kay, Scott Rodney, 'Can a familial gastrointestinal tumour syndrome be allelic with Waardenburg syndrome?', Clinical Genetics, 79 554-560 (2011) [C3]

Letter or Note (C4) (1 outputs)

Year	Citation	Nova
2002	Fletcher Ja, Fletcher Cdm, Rubin Bp, Ashman Leonie Kay, Corless Cl, Heinrich Mc, 'KIT Gene Mutations in Gastrointestinal Stromal Tumors - More Complex than Previously Recognized?', American Journal of Pathology, 161, No 2 737-738 (2002) [C4]

Conference Publication (13 outputs)

Full Written Paper - Refereed (E1) (1 outputs)

Year	Citation	Nova
2004	Griffith Renate, Foster Rowan Clare, Brown Michael Nicholas, Ashman Leonie Kay, 'Design of inhibitors of the KIT receptor tyrosine kinase', EuroQSAR 2004 Proceedings, Instanbul, Turkey (2004) [E1]

Extract of Paper (E3) (12 outputs)

Year	Citation	Nova
2012	Bond Danielle Renae, Cairns Murray John, Ashman Leonie Kay, Weidenhofer Judith Clare, 'Investigating micro-RNA regulation of tetraspanins CD151 and CD9 in prostate cancer', Febs Journal, Seville, Spain (2012) [E3]
2011	Mashkani Baratali, Ashman Leonie Kay, Griffith Renate, 'Implication of molecular docking in the study of structure-activity relationship of receptor tyrosine kinases inhibitors', Clinical Biochemistry, Mashhad, Iran (2011) [E3]
2011	Naudin C, Weidenhofer Judith Clare, Scott Rodney, Ashman Leonie Kay, Roselli Severine Melanie, 'Induction of mindin expression is associated with glomerular basement membrane damage in Cd151(-/-) mice', Nephrology, Adelaide, SA (2011) [E3]
2011	Vilain R, Braye S G, Ashman Leonie Kay, Scott Rodney, 'BRAF and NRAS mutational status are prognostically important in thick and locally advanced cutaneous melanoma', Pigment Cell & Melanoma Research, Tampa, FL (2011) [E3]
2010	Copeland Ben Troy, Vilain Ricardo Enrique, Ashman Leonie Kay, 'Biomarkers and regulatory proteins in prostate cancer', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
2010	Verrills Nicole Margaret, Roberts Kathryn Grace, Smith Amanda Melanie, McDougall Fiona Karen, Carpenter Helen Christine, Neviani Paolo, Sim Alistair Thomas, Perrotti Danio, Ashman Leonie Kay, 'Targeting the tumour suppressor, PP2A, as a novel therapy for acute myeloid leukaemia', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
2010	Vilain Ricardo Enrique, Ashton Katie Ann, Bowden Nikola Ann, Braye Stephen Geoffrey, Ashman Leonie Kay, Scott R J, 'Clinicopathological and gene expression profiling of advanced melanoma harbouring KIT and common kinase mutations', Melanoma 2010 Congress. Oral and Poster Abstracts, Sydney, NSW (2010) [E3]
2010	Vilain Ricardo Enrique, Braye Stephen Geoffrey, Ashman Leonie Kay, Scott Rodney, 'Characterisation of KIT mutated melanomas: A step in the development of patient-tailored treatement for melanoma', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
2008	Mashkani Baratali, Kim Kyu-Tae, Griffith Renate, Ashman Leonie Kay, 'Different behaviour of FDC-P1 cells expressing different FLT3 activating mutations', HMRI Conference on Translational Cancer Research Abstracts, Newcastle, NSW (2008) [E3]
2007	Roberts Kathryn Grace, Ashman Leonie Kay, Sim Alistair Thomas, Verrills Nicole Margaret, 'Regulation of protein phosphatase 2A (PP2A) B subunits by Bcr/Abl: Potential targets for chronic myeloid leukemia', AACR Meeting Abstracts Online (Abstracts of the 98th AACR Annual Meeting), Los Angeles (2007) [E3]
2004	Foster Rowan Clare, Griffith Renate, Ferrao Petranel Theresa, Ashman Leonie Kay, 'Molecular Modelling of c-Kit Kinase Domains', MM2004: 9th Molecular Modelling Workshop, Sydney, Australia (2004) [E3]
2003	Ashman Leonie Kay, Ferrao Petranel Theresa, Foster Rowan Clare, Griffith Renate, 'Analysis of the Structure of the Kinase Domain of the Stem Cell Factor Receptor Tyrosin Kinase (c-Kit) - Constitutive Activation by a D816V Mutation and Inhibition by STI571', Fifth AFMC International Medicinal Chemistry Symposium AIMECS 03, Kyoto, Japan (2003) [E3]

The University of Newcastle, Australia