Conjoint Prof. Leonie Ashman
|Work Phone||(08) 8376 9069|
School of Biomedical Sciences and Pharmacy
The University of Newcastle, Australia
Professor Ashman is a NHMRC Principal Research Fellow and Gladys Brawn Professorial Fellow. She came to the University of Newcastle in 2002 from the Hanson Centre for Cancer Research and the University of Adelaide. In her career spanning 35 years she has published 150 papers in refereed international journals and conference proceedings. Career highlights include identification at the protein level of the receptor tyrosine kinase c-KIT, publication of the first monoclonal antibody to it, and the first description of c-KIT expression by haemopoietic progenitor cells in bone marrow. She has an ongoing interest in the role of mutant c-KIT in acute myeloid leukaemia and other cancers and in new drugs that target this receptor. Prof Ashman's group also identified a novel tetraspanin protein, CD151, cloned the gene, and generated the first CD151 knock-out mice. Work in this and other laboratories has shown that the CD151 protein modifies cell adhesion and migration and plays an important role in the spread (metastasis) of cancer.
- PhD, University of Adelaide
- Bachelor of Science (Honours), Flinders University
- Cell and Molecular biology of cancer
I was trained as a biochemist but worked for many years in immunology. In now consider myself as a cell and molecular biologist. The underlying theme of my research has always been cancer, its cellular and molecular biology and development of novel approaches to diagnosis and treatment. Major themes have been haemopoiesis and leukaemia, regulation of cellular behaviour by cell surface receptors, cellular signalling and development of novel targetted therapeutics.
Fields of Research
|060100||Biochemistry And Cell Biology||60|
|111299||Oncology And Carcinogenesis Not Elsewhere Classified||30|
|110199||Medical Biochemistry And Metabolomics Not Elsewhere Classified||10|
Centres and Groups
Committee/Associations (relevant to research).
- Joint convenor - Hunter Medical Research Institute International Conferences on Translational Cancer Research, 2004, 2006, 2008
- Member - Grant Review Panel - Cell Biology 2005,2006
- Member, 2001, 2002 - Research Fellowship Advisory Panel A
University of Newcastle (Australia)
|01/01/2006 - 01/12/2010|
National Health & Medical Research Council (Australia)
|01/01/2006 - 01/12/2011|
Glivec Solid Tumour Advisory Board
Novartis Pharma, United States (Conference Presentation - non published.)
Summer Research Conference: tetraspanins
Federation of American Societies of Experimental Biology, United States (Conference Presentation - non published.)
Initiated and coordinated B Health Sci (Hons) program in Experimental Medicine at Adelaide University,
Member, Graduate Studies Committee and Board of Research Education and Development at Adelaide University
Elected Staff Representative, Hanson Centre Executive
Member, Hanson Institute Strategic Advisory Committee
Member, NHMRC Research Fellowships Advisory Panel, 2001, 2002.
Member NHMRC Grant Review panel, 2005, 2006.
At University of Newcastle:
Member, Faculty of Health Research Management Committee (2002, 2003).
Research Portfolio Committee, 2004 (casual vacancy)
Member of multiple appointments committess and grant review panels.
- Cancer Biology
While I have always been employed in "Research Only" positions I have contributed extensively to teaching both at the University of Adelaide and the University of Newcastle. Currently I teach into the B Biomed Sci program in my areas of research expertise (Cancer biology and novel drug development).
- Cell and molecular biology of cancer
- New anti-cancer drugs
- Bachelor of Biomedical Sciences
- Doctor of Philosophy