Dr Geoffry De IuliIs
| Work Phone | (02) 4921 7295 |
|---|---|
| Fax | (02) 4921 6308 |
| Geoffry.Deiuliis@newcastle.edu.au | |
| Office | LS4-39, Life Sciences |
Highlighted Publications
| Year | Citation | Link |
|---|---|---|
| 2006 | De Iuliis Geoffry Nunzio, Wingate Jordana Kate, Koppers Adam John, McLaughlin Eileen Anne, Aitken Robert John, 'Definitive evidence for the nonmitochondrial production of superoxide anion by human spermatozoa', Journal of Clinical Endocrinology and Metabolism, 91 1968-1975 (2006) [C1]
This is a significant paper for the study of male infertility and spermatozoa.We were able to show, for the first time, that human spermatozoa can generate superoxide. |
|
| 2009 | De Iuliis Geoffry Nunzio, Newey Rhiannon Jade, King Bruce Victor, Aitken Robert John, 'Mobile phone radiation induces reactive oxygen species production and DNA damage in human spermatozoa in vitro', PLoS ONE, 4 e6446 (2009) [C1]
A first for the field, this study showed a string of cause and effect from oxidative stress to nuclear DNA damage and motility loss, shedding light on a mechanism of action of non-ionising radiation on biology. |
|
| 2009 | De Iuliis Geoffry Nunzio, Thomson Laura K, Mitchell Lisa Ann, Read Jane Margaret, Koppers Adam John, Hedges Andrew, Nixon Brett, Aitken Robert John, 'DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress', Biology of Reproduction, 81 517-524 (2009) [C1]
We established an assay which detects oxidative DNA damage in human spermatozoa. We showed that a large proportion of DNA damage incurred by human spermatozoa is mediated by oxidative stress. |
|
| 2008 | Koppers Adam John, De Iuliis Geoffry Nunzio, Read Jane Margaret, McLaughlin Eileen Anne, Aitken Robert John, 'Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa', Journal of Clinical Endocrinology & Metabolism, 93 3199-3207 (2008) [C1]
We present conclusive evidence that human spermatozoa produced superoxide via their mitochondria which leads to a range of adverse effects. |
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Publications
For items published while at an institution other that the University of Newcastle, details are shown in italics.
Click on a category title below to expand the list of citations for that specific category.
Chapters In A Book (4 outputs)
Chapter in A1 Book (B1) (4 outputs)
| Year | Citation | Link |
|---|---|---|
| 2012 | Aitken Robert John, De Iuliis Geoffry Nunzio, Baker Mark Andrew, 'Direct methods for the detection of reactive oxygen species in human semen samples', Studies on Men's Health and Fertility, Springer, New York, 275-299 (2012) [B1] | |
| 2012 | De Iuliis Geoffry Nunzio, King Bruce Victor, Aitken Robert John, 'Electromagnetic radiation and oxidative stress in the male germ line', Studies on Men's Health and Fertility, Springer, New York, 3-20 (2012) [B1] | |
| 2010 | Aitken Robert John, Baker Mark Andrew, De Iuliis Geoffry Nunzio, Nixon Brett, 'New insights into sperm physiology and pathology', Fertility Control, Springer, Berlin, 99-115 (2010) [B1] |
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| 2007 | Aitken Robert John, Roman Shaun Daryl, Baker Mark Andrew, De Iuliis Geoffry Nunzio, 'Redox regulation of DNA damage in the male germ line', Male-Mediated Developmental Toxicity, Royal Society of Chemistry, London, United Kingdom, 197-209 (2007) [B1] | |
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Journal Articles (25 outputs)
Refereed Article in a Scholarly Journal (C1) (22 outputs)
| Year | Citation | Link |
|---|---|---|
| 2012 | Aitken Robert John, Gibb Zamira, Mitchell Lisa Ann, Lambourne Sarah Renay, Connaughton Haley Sheree, De Iuliis Geoffry Nunzio, 'Sperm motility is lost in vitro as a consequence of mitochondrial free radical production and the generation of electrophilic aldehydes but can be significantly rescued by the presence of nucleophilic thiols', Biology of Reproduction, 87 1-11 (2012) [C1] | |
| 2012 | Aitken Robert John, Whiting Sara Jayne, De Iuliis Geoffry Nunzio, McClymont Samantha Louise, Mitchell Lisa Ann, Baker Mark Andrew, 'Electrophilic aldehydes generated by sperm metabolism activate mitochondrial reactive oxygen species generation and apoptosis by targeting succinate dehydrogenase', Journal of Biological Chemistry, 287 33048-33060 (2012) [C1]
We detail the mechanism of reactive oxygen species production in spermatozoa, which greatly progresses our groups previous insights into the mitochondria’s role in producing reactive oxygen species. [IF 5.1] |
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| 2010 | Aitken Robert John, De Iuliis Geoffry Nunzio, 'On the possible origins of DNA damage in human spermatozoa', Molecular Human Reproduction, 16 3-13 (2010) [C1] |
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| 2010 | Aitken Robert John, De Iuliis Geoffry Nunzio, Finnie Jane M, Hedges Andrew, McLachlan Robert I, 'Analysis of the relationships between oxidative stress, DNA damage and sperm vitality in a patient population: Development of diagnostic criteria', Human Reproduction, 25 2415-2426 (2010) [C1] |
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| 2010 | Mitchell Lisa Ann, De Iuliis Geoffry Nunzio, Aitken Robert John, 'The TUNEL assay consistently underestimates DNA damage in human spermatozoa and is influenced by DNA compaction and cell vitality: Development of an improved methodology', International Journal of Andrology, 34 2-13 (2010) [C1] | |
| 2009 | Aitken Robert John, De Iuliis Geoffry Nunzio, McLachlan Robert I, 'Biological and clinical significance of DNA damage in the male germ line', International Journal of Andrology, 32 46-56 (2009) [C1] |
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| 2009 | Czarny Natasha Alexandra, Harris Merrilee Sue, De Iuliis Geoffry Nunzio, Rodger John Cameron, 'Acrosomal integrity, viability, and DNA damage of sperm from dasyurid marsupials after freezing or freeze drying', Theriogenology, 72 817-825 (2009) [C1] |
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| 2009 | De Iuliis Geoffry Nunzio, Newey Rhiannon Jade, King Bruce Victor, Aitken Robert John, 'Mobile phone radiation induces reactive oxygen species production and DNA damage in human spermatozoa in vitro', PLoS ONE, 4 e6446 (2009) [C1]
A first for the field, this study showed a string of cause and effect from oxidative stress to nuclear DNA damage and motility loss, shedding light on a mechanism of action of non-ionising radiation on biology. |
|
| 2009 | De Iuliis Geoffry Nunzio, Thomson Laura K, Mitchell Lisa Ann, Read Jane Margaret, Koppers Adam John, Hedges Andrew, Nixon Brett, Aitken Robert John, 'DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress', Biology of Reproduction, 81 517-524 (2009) [C1]
We established an assay which detects oxidative DNA damage in human spermatozoa. We showed that a large proportion of DNA damage incurred by human spermatozoa is mediated by oxidative stress. |
|
| 2009 | Thomson L K, Fleming S D, Aitken Robert John, De Iuliis Geoffry Nunzio, Zieschang J A, Clark A M, 'Cryopreservation-induced human sperm DNA damage is predominantly mediated by oxidative stress rather than apoptosis', Human Reproduction, 24 2061-2070 (2009) [C1] |
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| 2008 | Bennetts Liga Elizabeth, De Iuliis Geoffry Nunzio, Nixon Brett, Kime M, Nixon Katherine, McVicar C M, Lewis S E, Aitken Robert John, 'Impact of estrogenic compounds on DNA integrity in human spermatozoa: Evidence for cross-linking and redox cycling activities', Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 641 1-11 (2008) [C1] |
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| 2008 | Koppers Adam John, De Iuliis Geoffry Nunzio, Read Jane Margaret, McLaughlin Eileen Anne, Aitken Robert John, 'Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa', Journal of Clinical Endocrinology & Metabolism, 93 3199-3207 (2008) [C1]
We present conclusive evidence that human spermatozoa produced superoxide via their mitochondria which leads to a range of adverse effects. |
|
| 2007 | Aitken Robert John, De Iuliis Geoffry Nunzio, 'Origins and consequences of DNA damage in male germ cells', Reproductive Biomedicine Online, 14 727-733 (2007) [C1]
This article has been cited 114 times as of 2012. It details what is known about the types of DNA damage in the male germ line and their consequences for human fertility. [IF 2.3, 114 citations] |
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| 2007 | Aitken Robert John, De Iuliis Geoffry Nunzio, 'Value of DNA integrity assays for fertility evaluation', Society for Reproduction and Fertility Supplement, 65 81-92 (2007) [C1] | |
| 2007 | Aitken Robert John, Wingate Jordana Kate, De Iuliis Geoffry Nunzio, McLaughlin Eileen Anne, 'Analysis of lipid peroxidation in human spermatozoa using BODIPY C11', Molecular Human Reproduction, 13 203-211 (2007) [C1] | |
| 2006 | Aitken Robert John, Wingate Jordana Kate, De Iuliis Geoffry Nunzio, Koppers Adam John, McLaughlin Eileen Anne, 'Cis-unsaturated Fatty acids stimulate reactive oxygen species generation and lipid peroxidation in human spermatozoa', Journal of Clinical Endocrinology and Metabolism, 91 4154-4163 (2006) [C1] |
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| 2006 | De Iuliis Geoffry Nunzio, Wingate Jordana Kate, Koppers Adam John, McLaughlin Eileen Anne, Aitken Robert John, 'Definitive evidence for the nonmitochondrial production of superoxide anion by human spermatozoa', Journal of Clinical Endocrinology and Metabolism, 91 1968-1975 (2006) [C1]
This is a significant paper for the study of male infertility and spermatozoa.We were able to show, for the first time, that human spermatozoa can generate superoxide. |
|
| 2006 | McCann Nichola, De Iuliis Geoffry Nunzio, Lawrance Geoffrey Alan, Maeder Marcel, Schrader Karen, Moore Peter, 'Mono- and dinuclear copper(II) complexes of pendant-arm macrocyclic polyamines: Synthesis, characterization and investigation as hydrolytic cleavage agents for DNA', Inorganic Reaction Mechanisms, 6 91-112 (2006) [C1] |
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| 2004 | Robertson Mark James, De Iuliis Geoffry Nunzio, Maeder Marcel, Lawrance Geoffrey Alan, 'Metal-directed synthesis of a chiral acyclic pentaamine and pendant-arm macrocyclic hexaamine derived from an amino acid', Inorganica Chimica Acta, 357 557-570 (2004) [C1] | |
| 2003 | Comba P, De Iuliis Geoffry Nunzio, Lawrance Geoffrey Alan, Luther S, Maeder Marcel, Nolan Annette Louise, Robertson Mark James, Turner P, 'Geometrical isomerism in octahedral complexes arising from the presence of a fused ring on a triaza macrocycle', Dalton Transactions 2188-2193 (2003) [C1] | |
| 2002 | De Iuliis Geoffry Nunzio, Lawrance Geoffrey Alan, Wilson Nl, 'Metal complex-promoted cleavage of RNA dimers and trimers; electrospray ionisation mass spectrometry evidence for cleavage', Inorganic Reaction Mechanisms, 4 169-186 (2002) [C1] |
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| 2000 | De Iuliis Geoffry Nunzio, Lawrance Geoffrey Alan, Fieuw-Makaroff S, 'Superior hydrolytic DNA cleavage by a dinuclear copper(II) N4S4-donor complex compared with a mononuclear N2S2-donor close analogue', INORGANIC CHEMISTRY COMMUNICATIONS, 3 307-309 (2000) [C1]
Artificial nucleases were designed and synthesised. We proposed a 2-centred Cu(ii) complex would elevate rates of DNA hydrolytic cleavage. One compound exhibited one of the highest activities at the time. [IF 2.0, 32 citations] |
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Non Refereed Article in a Scholarly Journal (C2) (1 outputs)
| Year | Citation | Link |
|---|---|---|
| 2012 | Aitken Robert John, De Iuliis Geoffry Nunzio, Gibb Z, Baker Mark Andrew, 'The Simmet lecture: New horizons on an old landscape - oxidative stress, DNA damage and apoptosis in the male germ line', Reproduction in Domestic Animals, 47 7-14 (2012) [C2] |
Non Refereed Article in a Professional Journal (C3) (2 outputs)
| Year | Citation | Link |
|---|---|---|
| 2009 | Bennetts L E, De Iuliis Geoffry Nunzio, Nixon Brett, Kime M, Zelski K, McVicar C M, Lewis S E, Aitken Robert John, 'Impact of estrogenic compounds on DNA integrity in human spermatozoa: Evidence for cross-linking and redox cycling activities', Journal of Urology, 181 914-915 (2009) [C3] |
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| 2003 | De Iuliis Geoffry Nunzio, Lawrance Geoffrey Alan, Bernhardt Paul V, 'DNA cleavage with dinuclear metal complexes of ligands with varying flexibility', Journal of Inorganic Biochemistry, 96 158 (2003) [C3] |
Conference Publication (8 outputs)
Extract of Paper (E3) (8 outputs)
| Year | Citation | Link |
|---|---|---|
| 2008 | Aitken Robert John, De Iuliis Geoffry Nunzio, Nixon Brett, Roman Shaun Daryl, 'Causes and clinical significance of DNA damage in the male germ line', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction. "Reproductive Biology: Basic Discoveries that Affect Our Lives", Kailua-Kona, Hawaii (2008) [E3] | |
| 2008 | De Iuliis Geoffry Nunzio, Nixon Katherine, Aitken Robert John, 'Estrogenic compounds induce oxidative stress in human spermatozoa: Implications for DNA integrity and fertilization success', Biology of Reproduction, Kailua-Kona, Hawaii (2008) [E3] | |
| 2007 | Aitken Robert John, De Iuliis Geoffry Nunzio, 'Midnight's broken toll: The male germ cell and its role in the aetiology of genetic disease', Early Human Development, Perth, W.A. (2007) [E3] | |
| 2007 | De Iuliis Geoffry Nunzio, Zelski K, Aitken Robert John, 'The Impact of Estrogenic Compounds on DNA Integrity in the Male Germ Line', Endocrine Society of Australia (ESA) & Society for Reproductive Biology (SRB) Annual Scientific Meeting. Proceedings, Christchurch, New Zealand (2007) [E3] | |
| 2007 | Schjenken John Even, Stanger Simone Jacqueline, Smith V, Douglas Alicia, De Iuliis Geoffry Nunzio, Depaz I, Aitken Robert John, Gillam E, Roman Shaun Daryl, 'Expression and activity of phase 1 detoxifying enzymes in the male sperm line of the mouse', 7th Hunter Cellular Biology Meeting. Program, Hunter Valley, NSW (2007) [E3] | |
| 2006 | Aitken Robert John, De Iuliis Geoffry Nunzio, 'Value of DNA integrity assays for fertility evaluation', Abstracts, Madrid, Spain (2006) [E3] | |
| 2004 | De Iuliis Geoffry Nunzio, MacDougall Iain James Ashford, Griffith Renate, 'Molecular modelling of alpha 1b and alpha 1d adrenoceptors and investigations into the effects of water and adrenaline', MM2004: 9th Molecular Modelling Workshop, Sydney, Australia (2004) [E3] | |
| 2003 | De Iuliis Geoffry Nunzio, Griffith Renate, 'Molecular Dynamics Studies On A Model Of The a1b-Adrenergic Receptor: The Effects Of Water, Adrenaline And Site Directed Mutagenesis', TOMECS International Symposium AIMECS 03 Post Symposium Meeting Abstracts, Sunforte, Japan (2003) [E3] | |
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